Travis Nemkov, Davide Stefanoni, Aarash Bordbar, Aaron Issaian, Bernhard O Palsson, Larry J Dumont, Ariel Hay, Anren Song, Yang Xia, Jasmina S Redzic, Elan Z Eisenmesser, James C Zimring, Steve Kleinman, Kirk C Hansen, Michael P Busch, Angelo D'Alessandro
Computational models based on recent maps of the RBC proteome suggest that mature erythrocytes may harbor targets for common drugs. This prediction is relevant to RBC storage in the blood bank, in which the impact of small molecule drugs or other xenometabolites deriving from dietary, iatrogenic, or environmental exposures ("exposome") may alter erythrocyte energy and redox metabolism and, in so doing, affect red cell storage quality and posttransfusion efficacy. To test this prediction, here we provide a comprehensive characterization of the blood donor exposome, including the detection of common prescription and over-the-counter drugs in blood units donated by 250 healthy volunteers in the Recipient Epidemiology and Donor Evaluation Study III Red Blood Cell-Omics (REDS-III RBC-Omics) Study...
February 8, 2021: JCI Insight