Laura Winchester, Imelda Barber, Michael Lawton, Jessica Ash, Benjamine Liu, Samuel Evetts, Lucinda Hopkins-Jones, Suppalak Lewis, Catherine Bresner, Ana Belen Malpartida, Nigel Williams, Steve Gentlemen, Richard Wade-Martins, Brent Ryan, Alejo Holgado-Nevado, Michele Hu, Yoav Ben-Shlomo, Donald Grosset, Simon Lovestone
Biomarkers to aid diagnosis and delineate the progression of Parkinson's disease are vital for targeting treatment in the early phases of the disease. Here, we aim to discover a multi-protein panel representative of Parkinson's and make mechanistic inferences from protein expression profiles within the broader objective of finding novel biomarkers. We used aptamer-based technology (SomaLogic®) to measure proteins in 1599 serum samples, 85 cerebrospinal fluid samples and 37 brain tissue samples collected from two observational longitudinal cohorts (the Oxford Parkinson's Disease Centre and Tracking Parkinson's) and the Parkinson's Disease Brain Bank, respectively...
2023: Brain communications