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Blood bank regulations

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https://www.readbyqxmd.com/read/27887864/optimization-of-cgmp-purification-and-expansion-of-umbilical-cord-blood-derived-t-regulatory-cells-in-support-of-first-in-human-clinical-trials
#1
David H McKenna, Darin Sumstad, Diane M Kadidlo, Bjorn Batdorf, Colin J Lord, Sarah C Merkel, Christine M Koellner, Julie M Curtsinger, Carl H June, James L Riley, Bruce L Levine, Jeffrey S Miller, Claudio G Brunstein, John E Wagner, Bruce R Blazar, Keli L Hippen
BACKGROUND AIMS: Thymic-derived regulatory T cells (tTreg) are critical regulators of the immune system. Adoptive tTreg transfer is a curative therapy for murine models of autoimmunity, graft rejection, and graft-versus-host disease (GVHD). We previously completed a "first-in-human" clinical trial using in vitro expanded umbilical cord blood (UCB)-derived tTreg to prevent GVHD in patients undergoing UCB hematopoietic stem cell transplantation (HSCT). tTreg were safe and demonstrated clinical efficacy, but low yield prevented further dose escalation...
November 22, 2016: Cytotherapy
https://www.readbyqxmd.com/read/27807848/properties-of-donated-red-blood-cell-components-from-patients-with-hereditary-hemochromatosis
#2
Caroline Sut, Hind Hamzeh-Cognasse, Sandrine Laradi, Vincent Bost, Christine Aubrège, Sophie Acquart, Martine Vignal, Nadia Boutahar, Charles Antoine Arthaud, Marie Ange Eyraud, Bruno Pozzetto, Pierre Tiberghien, Olivier Garraud, Fabrice Cognasse
BACKGROUND: Red blood cells (RBCs) contain large amounts of iron, and periodic therapeutic phlebotomy is thus the main treatment for hereditary hemochromatosis (HH). However, the donation of therapeutic phlebotomy products from asymptomatic patients for transfusion purposes remains controversial. In this study, we compared the quality of RBCs obtained from HH patients with those of non-HH RBCs, within the allowed 42-day storage period. STUDY DESIGN AND METHODS: RBCs were obtained from HH patient donors and random regular blood donors by whole blood collection...
November 2, 2016: Transfusion
https://www.readbyqxmd.com/read/27699230/a-cord-blood-monocyte-derived-cell-therapy-product-accelerates-brain-remyelination
#3
Arjun Saha, Susan Buntz, Paula Scotland, Li Xu, Pamela Noeldner, Sachit Patel, Amy Wollish, Aruni Gunaratne, Tracy Gentry, Jesse Troy, Glenn K Matsushima, Joanne Kurtzberg, Andrew E Balber
Microglia and monocytes play important roles in regulating brain remyelination. We developed DUOC-01, a cell therapy product intended for treatment of demyelinating diseases, from banked human umbilical cord blood (CB) mononuclear cells. Immunodepletion and selection studies demonstrated that DUOC-01 cells are derived from CB CD14(+) monocytes. We compared the ability of freshly isolated CB CD14(+) monocytes and DUOC-01 cells to accelerate remyelination of the brains of NOD/SCID/IL2Rγ(null) mice following cuprizone feeding-mediated demyelination...
August 18, 2016: JCI Insight
https://www.readbyqxmd.com/read/27658344/transfusion-medicine-in-the-formosa-fun-coast-water-park-explosion-the-role-of-combined-tissue-and-blood-banking
#4
Chih-Chun Chang, Chin-Chuan Yeh, Fang-Yeh Chu
The Formosa Fun Coast explosion, occurring in a recreational water park located in the Northern Taiwan on 27 June 2015, made 499 people burn-injured. For those who had severe burn trauma, surgical intervention and fluid resuscitation were necessary, and potential blood transfusion therapy could be initiated, especially during and after broad escharotomy. Here, we reviewed the literature regarding transfusion medicine and skin grafting as well as described the practicing experience of combined tissue and blood bank in the burn disaster in Taiwan...
October 2016: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/27622800/seroprevalence-of-human-t-lymphotropic-virus-in-blood-bank-donors-at-fundaci%C3%A3-n-valle-del-lili-cali-colombia-2008-2014
#5
Carmenza Macía, Sandra Vargas, Ana María Mora, Ashly Melissa Sarmiento, Robinson Pacheco, Fernando Rosso
INTRODUCTION: Human lymphotropic virus (HTLV I/II) is a retrovirus that is prevalent across the Colombian Pacific coast, and is potentially transmissible by transfusion. Blood bank screening has been regulated since 2004, in order to reduce transmission of HTLV I/II through donation. Information on the seroprevalence of the virus in southwestern Colombia is limited.  OBJECTIVE: To determine the seroprevalence and the behavior of reactivity to HTLV I/II before and after the introduction of Western blot, and the comorbidity of HTLV and other infectious markers in donors from a blood bank in Cali, Colombia...
2016: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/27514515/chronic-viral-hepatitis-policy-regulation-and-strategies-for-its-control-and-elimination-in-ethiopia
#6
Fassil Shiferaw, Meketew Letebo, Abate Bane
BACKGROUND: Hepatitis B and C are silent killers not yet recognized as major public health challenges in many developing countries with huge disease burden. In Ethiopia, Hepatitis B is endemic with an average prevalence of 10.8 %, and the prevalence of Hepatitis C is 2 %. The prevalence of both infections, however, is likely to be underreported due to the lack of diagnostic facilities and appropriate surveillance systems. Ethiopia is also among the many Sub-Sahara African countries lacking a coordinated and systematic national response to chronic viral hepatitis...
August 11, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27494300/regulation-of-platelet-membrane-protein-shedding-in-health-and-disease
#7
Amanda E Au, Emma C Josefsson
Extracellular proteolysis of platelet plasma membrane proteins is an event that ensues platelet activation. Shedding of surface receptors such as glycoprotein (GP) Ibα, GPV and GPVI as well as externalized proteins P-selectin and CD40L releases soluble ectodomain fragments that are subsequently detectable in plasma. This results in the irreversible functional downregulation of platelet receptor-mediated adhesive interactions and the generation of biologically active fragments. In this review, we describe molecular insights into the regulation of platelet receptor and ligand shedding in health and disease...
August 5, 2016: Platelets
https://www.readbyqxmd.com/read/27405778/oxidative-modifications-of-glyceraldehyde-3-phosphate-dehydrogenase-regulate-metabolic-reprogramming-of-stored-red-blood-cells
#8
Julie A Reisz, Matthew J Wither, Monika Dzieciatkowska, Travis Nemkov, Aaron Issaian, Tatsuro Yoshida, Andrew J Dunham, Ryan C Hill, Kirk C Hansen, Angelo D'Alessandro
Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) plays a key regulatory function in glucose oxidation by mediating fluxes through glycolysis or the pentose phosphate pathway (PPP) in an oxidative stress-dependent fashion. Previous studies documented metabolic reprogramming in stored red blood cells (RBCs) and oxidation of GAPDH at functional residues upon exposure to pro-oxidants diamide and H2O2 Here we hypothesize that routine storage of erythrocyte concentrates promotes metabolic modulation of stored RBCs by targeting functional thiol residues of GAPDH...
September 22, 2016: Blood
https://www.readbyqxmd.com/read/27356356/-the-use-and-storage-of-stem-cells-and-cord-blood-french-and-english-law-comparative-approach
#9
COMPARATIVE STUDY
Allane Madanamoothoo
Becoming parents is one of the greatest wishes of a lot of couples. When their dreams come true, prior to the birth of the child, parents have to face several points: the choice of the name, place of delivery, breast or bottle feeding, etc. Recently, they have to face the issues of cord blood stem cells. Researchers and cord blood banks are also interested in those cells. In many countries a lot of advertising is made around umbilical cord blood stem cells. In France as in England, the use and preservation of cord blood are regulated by the legislators without necessarily having the same approach...
July 2015: Journal International de Bioéthique, International Journal of Bioethics
https://www.readbyqxmd.com/read/27348617/rural-blood-availability-regulations-must-meet-ethics
#10
Yogesh Jain, Raman Kataria
Rural physicians have been practising the technique of emergency bleeding and transfusion called Unbanked Directed (to a specific recipient) Blood Transfusion (UDBT), which has been declared illegal, to meet the need for blood in rural and inaccessible areas. As a result, a crisis has emerged in the availability of blood. Is UDBT a second rate technology for the poor and the disadvantaged? And should we not rather advocate for rapid scaling up of the establishment of blood banks in all areas? We examine the ethical issues related to blood availability in the rural areas...
June 21, 2016: Indian Journal of Medical Ethics
https://www.readbyqxmd.com/read/27076238/-marrow-donor-registration-and-cord-blood-banking-current-issues
#11
Minoko Takanashi
Marrow donor registration and cord blood banking are essential components of the infrastructure required for unrelated haemopoietic stem cell transplantations. We now have a new law to support and regulate the Marrow Donor Coordination Agency, Cord Blood Banks and the Haematopoietic Stem Cell Provision Support Organization. We also need to have a specific goal for bone marrow and peripheral blood stem cell donor registration, a minimum cord blood bank size, and the demographic data to back the medical needs for unrelated haemopoietic stem cell transplantations...
March 2016: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/27068218/the-involvement-of-erythrocyte-metabolism-in-organismal-homeostasis-in-health-and-disease
#12
Giel J C G M Bosman
Historically, study of erythrocyte homeostasis has focussed on the survival of erythrocytes in the blood bank and, especially in pathological circumstances, on the mechanisms leading to accelerated aging and removal from the circulation. Recent proteomic and metabolomic data suggest that erythrocyte metabolism involves more than ATP production and transport of oxygen and carbondioxide; is subject to regulation; and is likely to reflect organismal metabolism. Also, it has become clear that systemic diseases affect erythrocyte homeostasis...
August 2016: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/27001364/platelets-regulate-vascular-endothelial-stability-assessing-the-storage-lesion-and-donor-variability-of-apheresis-platelets
#13
Gyulnar Baimukanova, Byron Miyazawa, Daniel R Potter, Marcus O Muench, Roberta Bruhn, Stuart L Gibb, Philip C Spinella, Andrew P Cap, Mitchell J Cohen, Shibani Pati
BACKGROUND: In current blood banking practices, platelets (PLTs) are stored in plasma at 22°C, with gentle agitation for up to 5 days. To date, the effects of storage and donor variability on PLT regulation of vascular integrity are not known. STUDY DESIGN AND METHODS: In this study, we examined the donor variability of leukoreduced fresh (Day 1) or stored (Day 5) PLTs on vascular endothelial barrier function in vitro and in vivo. In vitro, PLT effects on endothelial cell (EC) monolayer permeability were assessed by analyzing transendothelial electrical resistances (TEER)...
March 2016: Transfusion
https://www.readbyqxmd.com/read/26906565/cytosolic-sulfotransferase-1a1-regulates-hiv-1-minus-strand-dna-elongation-in-primary-human-monocyte-derived-macrophages
#14
Justine Swann, Jeff Murry, John A T Young
BACKGROUND: The cellular sulfonation pathway modulates key steps of virus replication. This pathway comprises two main families of sulfonate-conjugating enzymes: Golgi sulfotransferases, which sulfonate proteins, glycoproteins, glycolipids and proteoglycans; and cytosolic sulfotransferases (SULTs), which sulfonate various small molecules including hormones, neurotransmitters, and xenobiotics. Sulfonation controls the functions of numerous cellular factors such as those involved in cell-cell interactions, cell signaling, and small molecule detoxification...
2016: Virology Journal
https://www.readbyqxmd.com/read/26886502/anti-fibrotic-characteristics-of-v%C3%AE-9-%C3%AE-%C3%AE-t-cells-in-systemic-sclerosis
#15
Noa Markovits, Anna Bendersky, Ronen Loebstein, Marina Brusel, Efrat Kessler, Ilan Bank
OBJECTIVES: γδ T cells of the Vγ9Vδ2 subtype secrete anti-fibrotic cytokines upon isopentenyl pyrophosphate (IPP) stimulation. In this study, we sought to compare IPP and Zoledronate, an up-regulator of IPP, effects on proliferation and cytokine secretion of Vγ9+ T cells from systemic sclerosis (SSc) patients and healthy controls (HCs). We also examined the effect of IPP-triggered peripheral blood mononuclear cells (PBMC) on fibroblast procolla- gen secretion. METHODS: PBMC from SSc patients and HCs were stimulated by increasing concentrations of Zoledronate, with or without IPP, and Vγ9+ T cell percentages were calculated using FACScan analysis...
February 9, 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/26844844/non-invasive-spectroscopy-of-transfusable-red-blood-cells-stored-inside-sealed-plastic-blood-bags
#16
K Buckley, C G Atkins, D Chen, H G Schulze, D V Devine, M W Blades, R F B Turner
After being separated from (donated) whole blood, red blood cells are suspended in specially formulated additive solutions and stored (at 4 °C) in polyvinyl chloride (PVC) blood-bags until they are needed for transfusion. With time, the prepared red cell concentrate (RCC) is known to undergo biochemical changes that lower effectiveness of the transfusion, and thus regulations are in place that limit the storage period to 42 days. At present, RCC is not subjected to analytical testing prior to transfusion. In this study, we use Spatially Offset Raman Spectroscopy (SORS) to probe, non-invasively, the biochemistry of RCC inside sealed blood-bags...
March 7, 2016: Analyst
https://www.readbyqxmd.com/read/26779485/cord-blood-banking-standards-autologous-versus-altruistic
#17
REVIEW
Sue Armitage
Cord blood (CB) is either donated to public CB banks for use by any patient worldwide for whom it is a match or stored in a private bank for potential autologous or family use. It is a unique cell product that has potential for treating life-threatening diseases. The majority of CB products used today are for hematopoietic stem cell transplantation and are accessed from public banks. CB is still evolving as a hematopoietic stem cell source, developing as a source for cellular immunotherapy products, such as natural killer, dendritic, and T-cells, and fast emerging as a non-hematopoietic stem cell source in the field of regenerative medicine...
2015: Frontiers in Medicine
https://www.readbyqxmd.com/read/26656549/alterations-of-rbc-membrane-proteins-in-diabetic-patients-with-and-without-periodontitis
#18
T Gabunia, S Turabelidze-Robaqidze, R Sujashvili, I Ioramashvili, N Gogebashvili, T Sanikidze
The RBC membrane is considered as a key element in their rheology. The rheological properties of RBCs significantly depend on their membranes properties - deformability. The essential contribution of integral membrane proteins in establishing/maintaining membrane stability is due to their ability to anchor the membrane skeleton to the lipid bilayer, their capacity to bind and stabilize membrane lipids, and their ability to influence and regulate local membrane curvature. The goal of the research was investigation the alterations in RBC membrane protein component in diabetic patients with or without periodontitis...
November 2015: Georgian Medical News
https://www.readbyqxmd.com/read/26593779/high-mortality-among-children-with-sickle-cell-anemia-and-overt-stroke-who-discontinue-blood-transfusion-after-transition-to-an-adult-program
#19
Joseph F McLaughlin, Samir K Ballas
BACKGROUND: Chronic blood transfusion is the standard of care in the management of overt stroke due to sickle cell anemia (SS) to prevent recurrence of stroke. The problem arises when children are transitioned to adult care where blood transfusion may be discontinued. The purpose of this study was to report the outcome of 22 patients with SS and overt stroke who were transitioned to our adult program between 1993 and 2009. STUDY DESIGN AND METHODS: Transitioned patients were kept on chronic blood transfusion they had as children...
May 2016: Transfusion
https://www.readbyqxmd.com/read/26581381/metabolomic-fingerprint-of-severe-obesity-is-dynamically-affected-by-bariatric-surgery-in-a-procedure-dependent-manner
#20
COMPARATIVE STUDY
Ewa Gralka, Claudio Luchinat, Leonardo Tenori, Barbara Ernst, Martin Thurnheer, Bernd Schultes
BACKGROUND: Obesity is associated with multiple diseases. Bariatric surgery is the most effective therapy for severe obesity that can reduce body weight and obesity-associated morbidity. The metabolic alterations associated with obesity and respective changes after bariatric surgery are incompletely understood. OBJECTIVE: We comprehensively assessed metabolic alterations associated with severe obesity and distinct bariatric procedures. DESIGN: In our longitudinal observational study, we applied a (1)H-nuclear magnetic resonance-based global, untargeted metabolomics strategy on human serum samples that were collected before and repeatedly ≤1 y after distinct bariatric procedures [i...
December 2015: American Journal of Clinical Nutrition
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