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https://www.readbyqxmd.com/read/29906498/discovering-time-trends-of-the-german-populations-exposure-to-contaminants-by-analysis-of-human-samples-of-the-german-environmental-specimen-bank-esb
#1
Thomas Göen, Dominik Lermen, Jörg Hildebrand, Martina Bartel-Steinbach, Till Weber, Marike Kolossa-Gehring
The German Environmental Specimen Bank (ESB) is a monitoring instrument of the German Federal Ministry for the Environment, Nature Conservationand Nuclear Safety. The permanent biobank facility is run since 1981 containing environmental and human samples from Germany. All samples are collected according to standard operating procedures (SOP). An annually standardized collection of human samples at four different regional sites of the country has been established since 1997. Routine sampling is done once a year, recruiting healthy non occupationally exposed students aged 20-29 years, in an equal gender distribution...
June 12, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29868586/ultraviolet-based-pathogen-inactivation-systems-untangling-the-molecular-targets-activated-in-platelets
#2
REVIEW
Peter Schubert, Lacey Johnson, Denese C Marks, Dana V Devine
Transfusions of platelets are an important cornerstone of medicine; however, recipients may be subject to risk of adverse events associated with the potential transmission of pathogens, especially bacteria. Pathogen inactivation (PI) technologies based on ultraviolet illumination have been developed in the last decades to mitigate this risk. This review discusses studies of platelet concentrates treated with the current generation of PI technologies to assess their impact on quality, PI capacity, safety, and clinical efficacy...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29784641/intrinsic-apoptosis-circumvents-the-functional-decline-of-circulating-platelets-but-does-not-cause-the-storage-lesion
#3
Irina Pleines, Marion Lebois, Pradnya Gangatirkar, Amanda E Au, Rachael M Lane, Katya J Henley, Maria Kauppi, Jason Corbin, Ping Cannon, Jonathan Bernardini, Imala Alwis, Kate E Jarman, Sarah Ellis, Donald Metcalf, Shaun P Jackson, Simone M Schoenwaelder, Benjamin T Kile, Emma C Josefsson
The circulating life span of blood platelets is regulated by the pro-survival protein BCL-XL. It restrains the activity of BAK and BAX, the essential pro-death mediators of intrinsic apoptosis. Disabling the platelet intrinsic apoptotic pathway in mice by deleting BAK and BAX results in a doubling of platelet life span and concomitant thrombocytosis. Apoptotic platelets expose phosphatidylserine (PS) via a mechanism that is distinct from that driven by classical agonists. Whether there is any role for apoptotic PS in platelet function in vivo, however, is unclear...
May 21, 2018: Blood
https://www.readbyqxmd.com/read/29720275/different-effects-of-granulocyte-colony-stimulating-factor-and-erythropoietin-on-erythropoiesis
#4
Tzu-Lin Chen, Ya-Wen Chiang, Guan-Ling Lin, Hsin-Hou Chang, Te-Sheng Lien, Min-Hua Sheh, Der-Shan Sun
BACKGROUND: Red blood cells are the most abundant cells in the blood that deliver oxygen to the whole body. Erythropoietin (EPO), a positive regulator of erythropoiesis, is currently the major treatment for chronic anemia. Granulocyte colony-stimulating factor (G-CSF) is a multifunctional cytokine and a well-known regulator of hematopoietic stem cell proliferation, differentiation, and mobilization. The use of EPO in combination with G-CSF has been reported to synergistically improve erythroid responses in a group of patients with myelodysplastic syndromes who did not respond to EPO treatment alone; however, the mechanism remains unclear...
May 2, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29706966/dysregulated-cd25-and-cytokine-expression-by-%C3%AE-%C3%AE-t-cells-of-systemic-sclerosis-patients-stimulated-with-cardiolipin-and-zoledronate
#5
Helena Migalovich Sheikhet, Jose Villacorta Hidalgo, Paul Fisch, Alexandra Balbir-Gurman, Yolanda Braun-Moscovici, Ilan Bank
Objectives: γδ T cells, a non-conventional innate lymphocyte subset containing cells that can be activated by lipids and phosphoantigens, are abnormally regulated in systemic sclerosis (SSc). To further evaluate the significance of this dysregulation, we compared how exposure to an autoantigenic lipid, cardiolipin (CL), during co-stimulation with an amino-bisphosphonate (zoledronate, zol), affects the activation and cytokine production of SSc and healthy control (HC) γδ T cells. Methods: Expression of CD25 on Vγ9+ , Vδ1+ , and total CD3+ T cells in cultured peripheral blood mononuclear cells (PBMCs), their binding of CD1d tetramers, and the effect of monoclonal antibody (mAb) blockade of CD1d were monitored by flow cytometry after 4 days of in vitro culture...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29602840/vitamin-d-obesity-and-leptin-in-relation-to-bladder-cancer-incidence-and-survival-prospective-protocol-study
#6
Randi Elin Gislefoss, Jo Steinson Stenehjem, Helga Helseth Hektoen, Bettina Kulle Andreassen, Hilde Langseth, Karol Axcrona, Elisabete Weiderpass, Alison Mondul, Trude Eid Robsahm
INTRODUCTION: Bladder cancer (BC) (including renal pelvis, ureter and urethra) is one of the most common urogenital cancers and the fourth most frequent cancer in men in the USA. In Norway, the incidence of BC has increased over the last decades. The age-standardised incidence rates per 100 000 for 2011-2015 were 53.7 in men and 16.5 in women. Compared to the 5-year period 2006-2010, the percentage increase in incidence was 6.1% in men and 12.3% in women. The recurrence rate of BC is over 50%, the highest recurrence rate of any malignancy...
March 30, 2018: BMJ Open
https://www.readbyqxmd.com/read/29496890/neuroimmune-axes-of-the-blood-brain-barriers-and-blood-brain-interfaces-bases-for-physiological-regulation-disease-states-and-pharmacological-interventions
#7
REVIEW
Michelle A Erickson, William A Banks
Central nervous system (CNS) barriers predominantly mediate the immune-privileged status of the brain, and are also important regulators of neuroimmune communication. It is increasingly appreciated that communication between the brain and immune system contributes to physiologic processes, adaptive responses, and disease states. In this review, we discuss the highly specialized features of brain barriers that regulate neuroimmune communication in health and disease. In section I , we discuss the concept of immune privilege, provide working definitions of brain barriers, and outline the historical work that contributed to the understanding of CNS barrier functions...
April 2018: Pharmacological Reviews
https://www.readbyqxmd.com/read/29453790/amyloid-beta-1-40-is-associated-with-alterations-in-ng2-pericyte-population-ex-vivo-and-in-vitro
#8
Nina Schultz, Kristoffer Brännström, Elin Byman, Simon Moussaud, Henrietta M Nielsen, Anders Olofsson, Malin Wennström
The population of brain pericytes, a cell type important for vessel stability and blood brain barrier function, has recently been shown altered in patients with Alzheimer's disease (AD). The underlying reason for this alteration is not fully understood, but progressive accumulation of the AD characteristic peptide amyloid-beta (Aβ) has been suggested as a potential culprit. In the current study, we show reduced number of hippocampal NG2+ pericytes and an association between NG2+ pericyte numbers and Aβ1-40 levels in AD patients...
February 17, 2018: Aging Cell
https://www.readbyqxmd.com/read/29169241/gut-reactions-how-the-blood-brain-barrier-connects-the-microbiome-and-the-brain
#9
Aric F Logsdon, Michelle A Erickson, Elizabeth M Rhea, Therese S Salameh, William A Banks
A growing body of evidence indicates that the microbiome interacts with the central nervous system (CNS) and can regulate many of its functions. One mechanism for this interaction is at the level of the blood-brain barriers (BBBs). In this minireview, we examine the several ways the microbiome is known to interact with the CNS barriers. Bacteria can directly release factors into the systemic circulation or can translocate into blood. Once in the blood, the microbiome and its factors can alter peripheral immune cells to promote interactions with the BBB and ultimately with other elements of the neurovascular unit...
January 2018: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29111891/regenerative-medicine-in-india-trends-and-challenges-in-innovation-and-regulation
#10
Shashank S Tiwari, Sujatha Raman, Paul Martin
The government of India has heavily promoted research and development in regenerative medicine together with domestic innovation and business development initiatives. Together, these promise a revolution in healthcare and public empowerment in India. Several national and transnational linkages have emerged to develop innovative capacity, most prominently in stem cell and cord blood banking, as well as in gene therapy, tissue engineering, biomaterials and 3D printing. However, challenges remain of achieving regulatory oversight, viable outputs and equitable impacts...
October 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/28967644/umbilical-cord-blood-banking-in-the-worldwide-hematopoietic-stem-cell-transplantation-system-perspectives-for-ukraine
#11
T O Kalynychenko
Significant progress in the promotion of procedural technologies associated with the transplantation of hematopoietic stem cells caused a rapid increase in activity. The exchange of hematopoietic stem cells for unrelated donor transplantations is now much easier due to the relevant international professional structures and organizations established to support cooperation and standard setting, as well as rules for the functioning of both national donor registries and cord blood banks. These processes are increasing every year and are contributing to the outpacing rates of development in this area...
September 2017: Experimental Oncology
https://www.readbyqxmd.com/read/28914201/the-transport-mechanism-of-extracellular-vesicles-at-the-blood-brain-barrier
#12
Junichi Matsumoto, Tessandra Stewart, William A Banks, Jing Zhang
Recently, extracellular vesicles (EVs), like exosomes and microvesicles, have attracted attention as potent carriers of intercellular communication throughout the body, including the brain. They transmit biological signals from donor cells to recipient cells, and recent evidence suggests that they may even carry such signals to distant destinations through peripheral circulation. In the central nervous system (CNS), EVs contribute to maintaining normal neuronal function, as well as to the pathological development of neurodegenerative diseases...
2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28577645/seroprevalence-cost-per-donation-and-reduction-in-blood-supply-due-to-positive-and-indeterminate-results-for-infectious-markers-in-a-blood-bank-in-lima-peru
#13
Jeel Moya-Salazar, Roberto Ubidia-Incio, Maritza Incio-Grande, Jorgelina L Blejer, Carlos A Gonzalez
INTRODUCTION: Safety in Transfusion Medicine is subject to regulations and government legislation within a total quality framework. The aim of this study was to evaluate the impact of seroprevalence and indeterminate results on lost units and cost per donation. METHODS: A prospective cross-sectional study was performed in the Blood Bank and Transfusion Therapy Department of the Hospital Central de la Policia Nacional del Perú in Lima, Peru. All completed donations (replacement/voluntary) without complications were included in this study...
April 2017: Revista Brasileira de Hematologia e Hemoterapia
https://www.readbyqxmd.com/read/28488967/purinergic-control-of-red-blood-cell-metabolism-novel-strategies-to-improve-red-cell-storage-quality
#14
REVIEW
Kaiqi Sun, Angelo D'alessandro, Yang Xia
Transfusion of stored blood is regarded as one of the great advances in modern medicine. However, during storage in the blood bank, red blood cells (RBCs) undergo a series of biochemical and biomechanical changes that affect cell morphology and physiology and potentially impair transfusion safety and efficacy. Despite reassuring evidence from clinical trials, it is universally accepted that the storage lesion(s) results in the altered physiology of long-stored RBCs and helps explain the rapid clearance of up to one-fourth of long-stored RBCs from the recipient's bloodstream at 24 hours after administration...
October 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28413425/association-of-retinol-binding-protein-4-with-metabolic-syndrome-in-first-degree-relatives-of-type-2-diabetic-patients
#15
Marjan Tabesh, Atsa Noroozi, Masood Amini, Awat Feizi, Sahar Saraf-Bank, Maryam Zare
BACKGROUND: Retinol-binding protein 4 (RBP4) is known to regulate lipid and glucose metabolism and insulin resistance. The influences of RBP4 on metabolic syndrome (MS) are still unclear. The purpose of this study is to evaluate the association between serum levels of RBP4 and MS components in first-degree relations of type 2 diabetic patients. MATERIALS AND METHODS: This cross-sectional study was performed within the framework of the diabetes prevention project in Isfahan...
2017: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/28397097/blood-brain-barriers-in-obesity
#16
Elizabeth M Rhea, Therese S Salameh, Aric F Logsdon, Angela J Hanson, Michelle A Erickson, William A Banks
After decades of rapid increase, the rate of obesity in adults in the USA is beginning to slow and the rate of childhood obesity is stabilizing. Despite these improvements, the obesity epidemic continues to be a major health and financial burden. Obesity is associated with serious negative health outcomes such as cardiovascular disease, type II diabetes, and, more recently, cognitive decline and various neurodegenerative dementias such as Alzheimer's disease. In the past decade, major advancements have contributed to the understanding of the role of the central nervous system (CNS) in the development of obesity and how peripheral hormonal signals modulate CNS regulation of energy homeostasis...
July 2017: AAPS Journal
https://www.readbyqxmd.com/read/28391986/gene-products-promoting-remyelination-are-up-regulated-in-a-cell-therapy-product-manufactured-from-banked-human-cord-blood
#17
Paula Scotland, Susan Buntz, Pamela Noeldner, Arjun Saha, Tracy Gentry, Joanne Kurtzberg, Andrew E Balber
BACKGROUND AIMS: DUOC-01, a cell product being developed to treat demyelinating conditions, is composed of macrophages that arise from CD14+ monocytes in the mononuclear cell (MNC) population of banked cord blood (CB). This article demonstrates that expression of multiple gene products that promote remyelination is rapidly up-regulated during manufacturing of DUOC-01 from either MNC or purified CB CD14+ monocytes. METHODS: Cell cultures were initiated with MNC or with immunoselected CD14+ monocytes isolated from the same CB unit...
June 2017: Cytotherapy
https://www.readbyqxmd.com/read/28332632/loss-of-chromosome-y-leads-to-down-regulation-of-kdm5d-and-kdm6c-epigenetic-modifiers-in-clear-cell-renal-cell-carcinoma
#18
Madeleine Arseneault, Jean Monlong, Naveen S Vasudev, Ruhina S Laskar, Maryam Safisamghabadi, Patricia Harnden, Lars Egevad, Nazanin Nourbehesht, Pudchalaluck Panichnantakul, Ivana Holcatova, Antonin Brisuda, Vladimir Janout, Helena Kollarova, Lenka Foretova, Marie Navratilova, Dana Mates, Viorel Jinga, David Zaridze, Anush Mukeria, Pouria Jandaghi, Paul Brennan, Alvis Brazma, Jorg Tost, Ghislaine Scelo, Rosamonde E Banks, Mark Lathrop, Guillaume Bourque, Yasser Riazalhosseini
Recent genomic studies of sporadic clear cell renal cell carcinoma (ccRCC) have uncovered novel driver genes and pathways. Given the unequal incidence rates among men and women (male:female incidence ratio approaches 2:1), we compared the genome-wide distribution of the chromosomal abnormalities in both sexes. We observed a higher frequency for the somatic recurrent chromosomal copy number variations (CNVs) of autosomes in male subjects, whereas somatic loss of chromosome X was detected exclusively in female patients (17...
March 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28295356/red-blood-cell-metabolic-responses-to-refrigerated-storage-rejuvenation-and-frozen-storage
#19
Angelo D'Alessandro, Alan D Gray, Zbigniew M Szczepiorkowski, Kirk Hansen, Louise H Herschel, Larry J Dumont
BACKGROUND: Storage of red blood cells (RBCs) under blood bank conditions promotes metabolic modulation within the RBC. This "metabolic storage lesion" may affect the quality and safety of the transfused RBCs. The aim of this study is to determine the metabolic changes in stored RBCs over 42 days of routine storage followed by a US Food and Drug Administration-approved method of rejuvenation, freezing, and preparation for transfusion. STUDY DESIGN AND METHODS: We exploited a mass spectrometry-based metabolomics approach to monitor 42-day-stored citrate phosphate dextrose/AS-1 RBCs (n = 29) that were rejuvenated, glycerolized and frozen, then thawed and deglycerolized, and held for 24 hours at 1 to 6ºC in saline-glucose...
April 2017: Transfusion
https://www.readbyqxmd.com/read/28208668/redox-proteomics-and-platelet-activation-understanding-the-redox-proteome-to-improve-platelet-quality-for-transfusion
#20
REVIEW
Giona Sonego, Mélanie Abonnenc, Jean-Daniel Tissot, Michel Prudent, Niels Lion
Blood banks use pathogen inactivation (PI) technologies to increase the safety of platelet concentrates (PCs). The characteristics of PI-treated PCs slightly differ from those of untreated PCs, but the underlying reasons are not well understood. One possible cause is the generation of oxidative stress during the PI process. This is of great interest since reactive oxygen species (ROS) act as second messengers in platelet functions. Furthermore, there are links between protein oxidation and phosphorylation, another mechanism that is critical for cell regulation...
February 11, 2017: International Journal of Molecular Sciences
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