Adam M Deane, Waleed Alhazzani, Gordon Guyatt, Simon Finfer, John C Marshall, John Myburgh, Nicole Zytaruk, Miranda Hardie, Lois Saunders, Serena Knowles, Francois Lauzier, Marianne J Chapman, Shane English, John Muscedere, Yaseen Arabi, Marlies Ostermann, Balasubramanian Venkatesh, Paul Young, Lehana Thabane, Laurent Billot, Diane Heels-Ansdell, Abdulrahman A Al-Fares, Naomi E Hammond, R Hall, Dorrilyn Rajbhandari, Alexis Poole, Daniel Johnson, Mobeen Iqbal, Gilmar Reis, Feng Xie, Deborah J Cook
INTRODUCTION: The R e- Ev aluating the I nhibition of S tress E rosions (REVISE) Trial aims to determine the impact of the proton pump inhibitor pantoprazole compared with placebo on clinically important upper gastrointestinal (GI) bleeding in the intensive care unit (ICU), 90-day mortality and other endpoints in critically ill adults. The objective of this report is to describe the rationale, methodology, ethics and management of REVISE. METHODS AND ANALYSIS: REVISE is an international, randomised, concealed, stratified, blinded parallel-group individual patient trial being conducted in ICUs in Canada, Australia, Saudi Arabia, UK, US, Kuwait, Pakistan and Brazil...
November 15, 2023: BMJ Open