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whipples disease

Graham M Strub, Andrew L Kirsh, Mark E Whipple, Winston P Kuo, Rachel B Keller, Raj P Kapur, Mark W Majesky, Jonathan A Perkins
Infantile hemangioma (IH) is the most common vascular tumor of infancy, and it uniquely regresses in response to oral propranolol. MicroRNAs (miRNAs) have emerged as key regulators of vascular development and are dysregulated in many disease processes, but the role of miRNAs in IH growth has not been investigated. We report expression of C19MC, a primate-specific megacluster of miRNAs expressed in placenta with rare expression in postnatal tissues, in glucose transporter 1-expressing (GLUT-1-expressing) IH endothelial cells and in the plasma of children with IH...
2016: JCI Insight
Qing Lin, Langping Tan, Yu Zhou, Quanbo Zhou, Rufu Chen
OBJECTIVE: To explore the clinical value of the radical nerve dissection (RND) for the carcinoma of head of pancreas (CHP). METHODS: The clinical and pathological data of 30 CHP patients who underwent RND in our hospital were retrospectively analyzed, with an attempt to explore the safety and short-term efficacy of this procedure. RESULTS: Among these 30 patients, the operative time was (351±61) min, the intra-operative blood loss was 350 (range, 300-600) mL, and the grades B and C pancreatic fistula was 23...
August 2016: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
A I Parfenov, L M Krums
The paper presents a variety of clinical manifestations of malabsorption syndrome (MAS) in celiac disease, collagenous sprue, Whipple's disease, Crohn's disease, intestinal lymphangiectasia, amyloidosis, common variable immune deficiency, and treatment of short bowel syndrome. It shows the specific features of the pathophysiology, diagnosis, and treatment of MAS in small bowel diseases.
2016: Terapevticheskiĭ Arkhiv
Maria Lisboa, Isabel Domingues, Jaime Pamplona, Pedro Barata, Joana Morgado, Vítor Brotas
PURPOSE: To describe a clinical case and literature review of Whipple disease. METHODS: A 65-year-old male with bilateral decreased visual acuity for 3 weeks as well as bilateral hypoacusia, vertigo, disequilibrium, headache and decreased strength in the right upper limb for 4 months. The clinical work-up revealed a bilateral panuveitis and an ischemic cerebellar stroke. RESULT: The diagnosis of Whipple disease was confirmed by histopathological analysis of adenopathy...
2014: GMS Ophthalmol Cases
Mohamed Kilani, Leila Njim, Atef Ben Nsir, Mohamed Nejib Hattab
Although neurological features are commonly encountered in Whipple's disease (WD), presentation with purely neurologic patterns is uncommon. Exclusive confinement to the central nervous system (CNS) is extremely rare. In these cases, the development of isolated cerebral mass is exceptional. In the present paper, the authors describe a case of a 68-year-old man who presented with partial seizures. The neurological examination was normal. The imaging showed a cystic lesion. This tumor-like lesion was removed by performing frontal craniotomy...
May 5, 2016: Turkish Neurosurgery
Azfar Niazi, Muhammad W Saif
Cholangiocarcinoma (bile ducts cancer) is a rare and aggressive form of cancer. It metastasizes frequently to liver, peritoneum, and lungs. Colon metastasis is extremely uncommon. We report here a 70-year-old male who was diagnosed with cholangiocarcinoma for which he underwent a Whipple procedure. Fifteen months later, a CT scan revealed mural thickening in the colon; this was supplemented with a PET scan, which confirmed this mass. Histological diagnosis of metastatic cholangiocarcinoma to the colon was made and the patient was treated with chemotherapy...
2016: Curēus
Jason J Bailey, James H Ellis, Matthew S Davenport, Richard H Cohan, Bin Nan, Aishwarya Parameswaran, Lin Hsu, Vaibhav Sahai, Isaac R Francis
PURPOSE: The purpose of this study was to determine the frequency in which the pelvis component of an abdominopelvic CT provides information that would influence clinical management in two separate groups of patients: those with previously resected pancreatic ductal adenocarcinoma (PDA) and those with locally advanced unresectable PDA. METHODS: This institutional review-board approved HIPAA compliant retrospective study with waived informed consent included 247 subjects with histologically proven PDA, including 153 subjects post-pancreaticoduodenectomy and 94 subjects with locally advanced unresectable disease...
August 13, 2016: Abdominal Radiology
Matthias Mehdorn, Tim-Ole Petersen, Michael Bartels, Boris Jansen-Winkeln, Woubet Tefera Kassahun
BACKGROUND: Psoas abscess is a rare clinical disease of various origins. Most common causes include hematogenous spread of bacteria from a different primary source, spondylodiscitis or perforated intestinal organs. But rarely some abscesses are related to malignant metastatic disease. CASE PRESENTATION: In this case report we present the case of a patient with known squamous cell carcinoma of the cervix treated with radio-chemotherapy three years prior. She now presented with a psoas abscess and subsequent complete inferior vena cava thrombosis, as well as duodenal and vertebral infiltration...
2016: BMC Surgery
Xavier Puéchal
Whipple's disease is a chronic systemic infection that is due to the bacterial agent Tropheryma whipplei and can be cured by appropriate antibiotic therapy. The typical patient is a middle-aged man. Rheumatologists are in a prime position to handle Whipple's disease. The classical presentation combines weight loss and diarrhea, preceded in three-quarters of patients by a distinctive pattern of joint manifestations that run an intermittent course, at least initially. The mean time from joint symptom onset to the diagnosis of Whipple's disease is 6 years...
August 5, 2016: Joint, Bone, Spine: Revue du Rhumatisme
D Stamatova, L Theilmann, C Spiegelberg
Hepatoid carcinoma (HC) is an extremely rare form of neoplasm. Its cellular structure resembles that of a hepatocellular carcinoma (HCC). To date, only 26 cases of hepatoid carcinoma of the pancreas have been reported in the literature. We report the diagnosis of a hepatoid carcinoma of the pancreatic head in a 78-year-old male patient. The tumor was detected incidentally during routine abdominal ultrasound scanning. Laboratory tests did not show any abnormalities except for a monoclonal gammopathy of undetermined significance...
December 2016: Surgical Case Reports
Bhanu Jayanand Sunil, Ramakrishnan A Seshadri, S Gouthaman, Rama Ranganathan
PURPOSE: The aim of the study was to analyze the long-term survival and the various prognostic factors that influence overall survival in patients undergoing pancreaticoduodenectomy (PD) with non-pancreatic periampullary carcinomas. METHODS: A retrospective analysis of consecutive patients diagnosed with non-pancreatic periampullary carcinomas who underwent PD at a tertiary cancer center was performed. Univariate analysis of various prognostic factors influencing the disease-free survival (DFS) was performed using log-rank test...
August 3, 2016: Journal of Gastrointestinal Cancer
Begoña Díaz, Katherine T Ostapoff, Jason E Toombs, Jason Lo, Michael Y Bonner, Adam Curatolo, Volkan Adsay, Rolf A Brekken, Jack L Arbiser
Pancreatic carcinoma ranks among the most lethal of human cancers. Besides late detection, other factors contribute to its lethality, including a high degree of chemoresistance, invasion, and distant metastases. Currently, the mainstay of therapy involves resection of local disease in a minority of patients (Whipple procedure) and systemic gemcitabine. While systemic chemotherapy has some benefit, even with optimal treatment, the five year survival after diagnosis is dismal. Thus, treatment of pancreatic carcinoma remains a tremendous unmet need...
July 9, 2016: Oncotarget
Jean-Christophe Lagier, Laurent Papazian, Florence Fenollar, Sophie Edouard, Cléa Melenotte, Sophie Laroumagne, Gérard Michel, Claude Martin, Marc Gainnier, Caroline Lions, Patrizia Carrieri, Andreas Stein, Philippe Brouqui, Didier Raoult
OBJECTIVES: Tropheryma whipplei, the causative bacterium of Whipple's disease, can cause acute pneumonia. We performed a case-control study including patients with T. whipplei in bronchoalveolar lavages (BAL) and controls in order to compare patient's clinical statuses. METHODS: We tested T. whipplei PCR from January 2013 to December 2014, all the 1,438 BAL in Marseille, France. Controls were hospitalized in the same unit during the same period and were comparable in age and sex...
July 15, 2016: Clinical Microbiology and Infection
Daniel Hartmann, Benedikt Kaufmann, Helmut Friess
PURPOSE OF REVIEW: Surgery for pancreatic diseases is one of the most studied fields in general surgery and continues to evolve. This review focuses on recent advances in pancreatic surgery and summarizes the published research. RECENT FINDINGS: Surgery for pancreatic diseases is an evolving field with a wide range of innovations. Especially, contributions by high-volume pancreas centers have greatly improved outcomes in pancreatic surgery. In chronic pancreatitis, recent studies demonstrate that early surgical treatment should be favored over repeated endoscopic interventions, and local organ-preserving resection techniques should be preferred over classic Whipple resection...
July 15, 2016: Current Opinion in Gastroenterology
E I Mantonakis, D N Moris, D F Diamantis, A M Pazaiti, A E Papalampros
We present a patient with symptomatic pancreatic disease. Extensive preoperative workup could not reveal the diagnosis beyond doubt, so Whipple's resection was performed, in order to exclude pancreatic adenocarcinoma. Since differential diagnosis between autoimmune pancreatitis and pancreatic cancer cannot be made based only on clinical findings, serological and imaging examinations, and biopsy is not always feasible, many patients have to undergo surgery. Autoimmune pancreatitis is the most common manifestation of a newly recognized entity, IgG4-related systemic disease, affecting many organs and sites...
June 16, 2015: West Indian Medical Journal
P Lehmann, B Ehrenstein, W Hartung, C Dragonas, U Reischl, M Fleck
OBJECTIVES: The diagnosis of Whipple's disease (WD) is commonly confirmed by histology demonstrating Periodic Acid Schiff (PAS)-positive macrophages in the duodenal mucosa. Analysis of intestinal tissue or other specimens using polymerase chain reaction (PCR) is a more sensitive method. However, the relevance of positive PCR findings is still controversial. Therefore, we evaluated the relevance of histology and PCR findings to establishing the diagnosis of WD in a series of WD patients initially presenting with suspected rheumatic diseases...
July 11, 2016: Scandinavian Journal of Rheumatology
Miguel Tábuas-Pereira, Margarida Vicente, Filomena Coelho, Isabel Santana
Whipple disease is a rare, chronic multisystem infectious disease. The central nervous system (CNS) is secondarily involved in 43% of patients; 5% of patients have isolated or primary CNS involvement. The most frequent CNS symptoms are cognitive changes. Prosopagnosia is an inability to recognize familiar faces, in a person who does not have vision impairments or cognitive alterations. This relatively rare condition is usually related to vascular, traumatic, degenerative, or infectious lesions. We report a 54-year-old woman who presented subacutely with fever, headache, and seizures that led to a diagnosis of infectious meningoencephalitis...
June 2016: Cognitive and Behavioral Neurology: Official Journal of the Society for Behavioral and Cognitive Neurology
Hubert Bassene, Oleg Mediannikov, Cristina Socolovschi, Pavel Ratmanov, Alpha K Keita, Cheikh Sokhna, Didier Raoult, Florence Fenollar
The bacterium Tropheryma whipplei, which causes Whipple disease in humans, is commonly detected in the feces of persons in Africa. It is also associated with acute infections. We investigated the role of T. whipplei in febrile patients from 2 rural villages in Senegal. During June 2010-March 2012, we collected whole-blood finger-prick samples from 786 febrile and 385 healthy villagers. T. whipplei was detected in blood specimens from 36 (4.6%) of the 786 febrile patients and in 1 (0.25%) of the 385 apparently healthy persons...
July 2016: Emerging Infectious Diseases
V A Khorzhevsky, S V Gappoev
The paper describes a case of the postmortem diagnosis of Whipple's disease, a rare bacterial infection, in a patient with multiple organ dysfunction showing intestinal manifestations with massive retroperitoneal lymphadenopathy. Histochemical and electron microscopic methods were used to examine the patient, which showed the morphological changes occurring in the lymph nodes and bowel and the ultrastructural characteristics of Tropheryma whipplei while examining the sections primarily fixed in formalin and embedded in paraffin...
May 2016: Arkhiv Patologii
E M Tsarfati, R Sutherland
No abstract text is available yet for this article.
June 2016: British Journal of Hospital Medicine
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