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Rectal cancer exosomes

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https://www.readbyqxmd.com/read/27032035/a-novel-urine-exosome-gene-expression-assay-to-predict-high-grade-prostate-cancer-at-initial-biopsy
#1
James McKiernan, Michael J Donovan, Vince O'Neill, Stefan Bentink, Mikkel Noerholm, Susan Belzer, Johan Skog, Michael W Kattan, Alan Partin, Gerald Andriole, Gordon Brown, John T Wei, Ian M Thompson, Peter Carroll
IMPORTANCE: Overdiagnosis and overtreatment of indolent prostate cancer (PCA) is a serious health issue in most developed countries. There is an unmet clinical need for noninvasive, easy to administer, diagnostic assays to help assess whether a prostate biopsy is warranted. OBJECTIVE: To determine the performance of a novel urine exosome gene expression assay (the ExoDx Prostate IntelliScore urine exosome assay) plus standard of care (SOC) (ie, prostate-specific antigen [PSA] level, age, race, and family history) vs SOC alone for discriminating between Gleason score (GS)7 and GS6 and benign disease on initial biopsy...
July 1, 2016: JAMA Oncology
https://www.readbyqxmd.com/read/26630694/comparative-analysis-of-prostate-cancer-specific-biomarkers-pca3-and-erg-in-whole-urine-urinary-sediments-and-exosomes
#2
Rianne J Hendriks, Siebren Dijkstra, Sander A Jannink, Martijn G Steffens, Inge M van Oort, Peter F A Mulders, Jack A Schalken
BACKGROUND: PCA3 and ERG are mRNA-based prostate cancer (PCa) specific biomarkers that can be detected in urine. However, urine is a complex substrate that can be separated in several fractions. In this study we compared the levels of PCa-specific biomarkers (PCA3 and ERG) and KLK3 as prostate-specific reference gene in three urine substrates-whole urine, urinary sediment (cell pellet) and exosomes-and evaluated the influence of performing a digital rectal examination (DRE) prior to urine sampling...
March 2016: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/26345389/a-molecular-signature-of-pca3-and-erg-exosomal-rna-from-non-dre-urine-is-predictive-of-initial-prostate-biopsy-result
#3
M J Donovan, M Noerholm, S Bentink, S Belzer, J Skog, V O'Neill, J S Cochran, G A Brown
BACKGROUND: New screening methods that can add predictive diagnostic value for aggressive (high-grade, Gleason score ⩾ 7) prostate cancer (PCa) are needed to reduce unnecessary biopsies for patients with non-aggressive PCa. This is particularly important for men presenting for an initial biopsy with an equivocal PSA in the 2-10 ng ml(-1) range. PCA3 and ERG are biomarkers that can add predictive value for PCa in urine; however, with a limited utility as a digital rectal exam (DRE) is required...
December 2015: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/26139298/immuno-based-detection-of-extracellular-vesicles-in-urine-as-diagnostic-marker-for-prostate-cancer
#4
Diederick Duijvesz, C Yin L Versluis, Christa A M van der Fels, Mirella S Vredenbregt-van den Berg, Janne Leivo, Mari T Peltola, Chris H Bangma, Kim S I Pettersson, Guido Jenster
Extracellular vesicles (including the subclass exosomes) secreted by cells contain specific proteins and RNA that could be of interest in determining new markers. Isolation/characterization of PCa-derived exosomes from bodily fluids enables us to discover new markers for this disease. Unfortunately, isolation with current techniques (ultracentrifugation) is labor intensive and other techniques are still under development. The goal of our study was to develop a highly sensitive time-resolved fluorescence immunoassay (TR-FIA) for capture/detection of PCa-derived exosomes...
December 15, 2015: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/24211598/prostate-cancer-biomarker-profiles-in-urinary-sediments-and-exosomes
#5
Siebren Dijkstra, Ingrid L Birker, Frank P Smit, Gisele H J M Leyten, Theo M de Reijke, Inge M van Oort, Peter F A Mulders, Sander A Jannink, Jack A Schalken
PURPOSE: Urinary biomarker tests for diagnosing prostate cancer have gained considerable interest. Urine is a complex mixture that can be subfractionated. We evaluated 2 urinary fractions that contain nucleic acids, ie cell pellets and exosomes. The influence of digital rectal examination before urine collection was also studied and the prostate cancer specific biomarkers PCA3 and TMPRSS2-ERG were assayed. MATERIALS AND METHODS: Urine samples were prospectively obtained before and after digital rectal examination from 30 men scheduled for prostate biopsy...
April 2014: Journal of Urology
https://www.readbyqxmd.com/read/21506012/expression-of-macrophage-antigens-by-tumor-cells
#6
REVIEW
Ivan Shabo, Joar Svanvik
Macrophages are a heterogeneous cell population of the myeloid linage derived from monocytes. These cells show two different polarization states, M1 and M2 macrophages in response to different micro environmental signals. Tumor associated macrophages (TAM) represent the M2 type and promote tumor progression. These cells express antigens that more or less are specific for macrophages like: CD14, CD68, MAC387, CD163, and DAP12. In a series of recent studies it is shown that cancer cells may express these antigens and CD163, MAC387 and DAP12 may be expressed by e...
2011: Advances in Experimental Medicine and Biology
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