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https://www.readbyqxmd.com/read/29667471/cost-effectiveness-analysis-of-suvorexant-for-the-treatment-of-japanese-elderly-patients-with-chronic-insnomnia-in-a-virtual-cohort
#1
Shinichi Nishimura, Mutsuhiro Nakao
AIMS: We assessed the cost effectiveness of the orexin receptor antagonist suvorexant against zolpidem, the most widely used hypnotic benzodiazepine receptor agonist in Japan. To this end, a model was used that factored in insomnia and the risk for hip fractures, which have devastating effects on the elderly. METHODS: Data were derived from published papers. The target population was a virtual cohort of elderly patients (≥65 years) with insomnia residing in Japan...
April 18, 2018: Journal of Medical Economics
https://www.readbyqxmd.com/read/29664207/how-sleep-problems-contribute-to-simulator-sickness-preliminary-results-from-a-realistic-driving-scenario
#2
Ellemarije Altena, Yannick Daviaux, Ernesto Sanz-Arigita, Emilien Bonhomme, Étienne de Sevin, Jean-Arthur Micoulaud-Franchi, Stéphanie Bioulac, Pierre Philip
Virtual reality and simulation tools enable us to assess daytime functioning in environments that simulate real life as close as possible. Simulator sickness, however, poses a problem in the application of these tools, and has been related to pre-existing health problems. How sleep problems contribute to simulator sickness has not yet been investigated. In the current study, 20 female chronic insomnia patients and 32 female age-matched controls drove in a driving simulator covering realistic city, country and highway scenes...
April 17, 2018: Journal of Sleep Research
https://www.readbyqxmd.com/read/29663115/sofosbuvir-plus-daclatasvir-with-or-without-ribavirin-for-treatment-of-chronic-hcv-genotype-4-patients-real-life-experience
#3
G Shiha, R Soliman, M ElBasiony, A A Hassan, N N H Mikhail
INTRODUCTION: New regimens involving direct-acting antiviral agents have recently been approved for the treatment of HCV. Our aim was to assess the efficacy and safety of 12 or 24 weeks of Sofosbuvir 400 mg plus Daclatasvir 60 mg, with or without ribavirin (800-1000 mg) in treating chronic hepatitis C genotype 4 patients. METHODS: This is an open-label observational study that describes the effect of 12 week or 24 weeks of daily oral Sofosbuvir (SOF) 400 mg plus Daclatasvir (DCV) 60 mg with or without ribavirin (RBV) with dose adjustment if indicated...
April 16, 2018: Hepatology International
https://www.readbyqxmd.com/read/29623059/cognitive-impairments-in-fibromyalgia-syndrome-associations-with-positive-and-negative-affect-alexithymia-pain-catastrophizing-and-self-esteem
#4
Carmen M Galvez-Sánchez, Gustavo A Reyes Del Paso, Stefan Duschek
Fibromyalgia syndrome (FMS) is a chronic condition characterized by widespread pain accompanied by symptoms like depression, anxiety, sleep disturbance and fatigue. In addition, affected patients frequently report cognitive disruption such as forgetfulness, concentration difficulties or mental slowness. Though cognitive deficits in FMS have been confirmed in various studies, not much is known about the mechanisms involved in their origin. This study aimed to investigate the contribution of affect-related variables to cognitive impairments in FMS...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29619109/polysomnography-applied-to-patients-with-tinnitus-a-review
#5
REVIEW
Liane Sousa Teixeira, Ronaldo Campos Granjeiro, Carlos Augusto Pires de Oliveira, Fayez Bahamad Júnior
Introduction  Tinnitus has been defined as an "auditory phantom perception," meaning that tinnitus results from an abnormal activity within the nervous system, in the absence of any internal or external acoustic stimulation. About 10 to 15% of the adult population is affected by tinnitus, and a relevant percentage of tinnitus sufferers experience symptoms severe enough to significantly affect quality of life, including sleep disturbances, work impairment, and, in some cases, psychiatric distress...
April 2018: International Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/29609939/a-novel-cognitive-behavioral-treatment-for-patients-with-chronic-insomnia-a-pilot-experimental-study
#6
Sofia Tsoli, Spyros Vasdekis, Xanthi Tigani, Artemios Artemiadis, George Chrousos, Christina Darviri
OBJECTIVES: Chronic insomnia (CI) is a common sleep disorder linked to stress and various ubiquitous stress-related disorders (e.g. cardiovascular and mental diseases). Previous experimental studies exploring the effects of stress management in CI have confirmed that reducing stress, especially through cognitive methods, could ameliorate symptoms and repercussions of CI. In this 16-week experimental pilot study, we primarily examined the feasibility of a novel method, dubbed Pythagorean Self-Awareness Intervention (PSAI) in 30 CI patients...
April 2018: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/29605692/catastrophizing-solicitous-responses-from-significant-others-and-function-in-individuals-with-neuropathic-pain-osteoarthritis-or-spinal-pain-in-the-general-population
#7
Mari Glette, Tormod Landmark, Mark P Jensen, Astrid Woodhouse, Stephen Butler, Petter C Borchgrevink, Tore C Stiles
That certain psychological factors are negatively associated with function in patients with chronic pain is well established. However, few studies have evaluated these factors in individuals with chronic pain from the general population. The aims of this study were to (1) evaluate the unique associations between catastrophizing and perceived solicitous responses and psychological function, physical function and insomnia severity in individuals with neuropathic pain, osteoarthritis or spinal pain in the general population and to (2) determine if diagnosis moderates the associations found...
March 29, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29576408/insomnia-and-hypertension-a-systematic-review
#8
REVIEW
Denise C Jarrin, Pasquale K Alvaro, Marc-André Bouchard, Stephanie D Jarrin, Christopher L Drake, Charles M Morin
Insomnia is a prevalent sleep disorder that is associated with a multitude of health consequences. Particularly, insomnia has been associated with cardiovascular disease and its precursors, such as hypertension and blood pressure (BP) non-dipping. The present systematic review aimed to summarize the evidence on the concurrent and prospective associations between insomnia and hypertension and/or BP. Using electronic search engines (PubMed, SCOPUS, PsycINFO), 5,618 articles published from January 1970 to December 2017 were identified, and 64 met the inclusion criteria (26 to 162,121 participants; age range: 18-100; 46...
February 16, 2018: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/29567512/the-effects-of-one-night-of-partial-sleep-deprivation-on-executive-functions-in-individuals-reporting-chronic-insomnia-and-good-sleepers
#9
Andrea Ballesio, Silvia Cerolini, Fabio Ferlazzo, Nicola Cellini, Caterina Lombardo
BACKGROUND AND OBJECTIVES: The aim of the present study was to investigate the effects of a partial sleep deprivation night on executive functions in participants reporting chronic insomnia and good sleepers using a Task Switching paradigm. METHODS: Sixteen participants reporting symptoms of chronic insomnia and sixteen good sleepers were tested after a night of habitual sleep and after a night of partial sleep deprivation (5 h of sleep allowed). The Switch Cost (SC) and the Backward Inhibition (BI) were computed as measures of switching attention and response inhibition, respectively...
February 15, 2018: Journal of Behavior Therapy and Experimental Psychiatry
https://www.readbyqxmd.com/read/29558967/the-efficacy-of-the-traditional-chinese-medicine-juanbi-pill-combined-with-methotrexate-in-active-rheumatoid-arthritis-study-protocol-for-a-randomized-controlled-trial
#10
Qiong Wang, Yi-Ru Wang, Qing-Yun Jia, Li Liu, Chong-Qing Xu, Xiao-Yun Wang, Min Yao, Xue-Jun Cui, Qi Shi, Yong-Jun Wang, Qian-Qian Liang
BACKGROUND: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by swelling and painful joints, eventually leading to joint destruction. There is still a lack of effective therapy to treat RA. The Juanbi pill is a Chinese medicine that has been widely used to treat active RA in China for hundreds of years, relieving pain and protecting the affected joints from malformation. However, there is no solid evidence to show the effect of the Juanbi pill on the management of active RA...
March 20, 2018: Trials
https://www.readbyqxmd.com/read/29555133/the-association-between-insomnia-and-bedroom-habits-and-bedroom-characteristics-an-exploratory-cross-sectional-study-of-a-representative-sample-of-adults
#11
Bjørn Bjorvatn, Siri Waage, Ståle Pallesen
OBJECTIVES: Major age and sex differences are reported in bedroom habits and bedroom characteristics. However, few studies have investigated whether such bedroom habits and characteristics differ between patients with chronic insomnia disorder and good sleepers. METHODS: We assessed the association between several bedroom habits (i.e. electronic media use, bed sharing) and bedroom characteristics (i.e. bedroom temperature, blackout curtains) and chronic insomnia disorder among 1001 randomly selected adults responding to a telephone survey in Norway...
April 2018: Sleep Health
https://www.readbyqxmd.com/read/29553787/qualitative-exploration-of-traumatic-brain-injury-related-beliefs-among-u-s-military-veterans
#12
Paul R King, Gregory P Beehler, Bonnie M Vest, Kerry Donnelly, Laura O Wray
PURPOSE/OBJECTIVE: Explore cognitive, affective, and experiential factors that inform veterans' traumatic brain injury (TBI)-related beliefs. Research Method/Design: Qualitative descriptive study of 22 veterans who received care for TBI at a VA Medical Center in the Northeastern United States using directed content analysis. Measures included a semistructured interview, demographic survey, the Alcohol Use Disorders Identification Test-Consumption Items (AUDIT-C), Patient Health Questionnaire-9 (PHQ-9), PTSD Checklist (PCL), Neurobehavioral Symptom Inventory (NSI), and Insomnia Severity Index (ISI)...
February 2018: Rehabilitation Psychology
https://www.readbyqxmd.com/read/29550236/clinically-oriented-subtyping-of-chronic-insomnia-of-childhood
#13
Oliviero Bruni, Stefania Sette, Marco Angriman, Emma Baumgartner, Lara Selvaggini, Cristina Belli, Raffaele Ferri
OBJECTIVES: To identify different profiles of pediatric insomnia, based on the most frequent clinical presentations (nocturnal awakenings, difficulty in falling asleep, nocturnal restlessness, early morning awakenings). STUDY DESIGN: A structured parent interview was conducted in 338 children (mean age 21.29 months, SD 10.56) referred by pediatricians because of insomnia resistant to behavioral approaches and common drug treatments. The aim was to assess the characteristics of insomnia in children, together with family sleep-related history...
March 15, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29547622/dispositional-mindfulness-anticipation-and-abstinence-symptoms-related-to-hypnotic-dependence-among-insomniac-women-who-seek-treatment-a-cross-sectional-study
#14
Víviam Vargas Barros, Emérita Sátiro Opaleye, Marcelo Demarzo, Sarah Bowen, Daniela Fernández Curado, Helena Hachul, Ana Regina Noto
INTRODUCTION: Dispositional mindfulness can be described as the mental ability to pay attention to the present moment, non-judgmentally. There is evidence of inverse relation between dispositional mindfulness and insomnia and substance use, but as of yet, no studies evaluating the specific association between dispositional mindfulness and the components of hypnotic use disorder. OBJECTIVE: To evaluate the association between dispositional mindfulness and the components of dependence among female chronic hypnotic users...
2018: PloS One
https://www.readbyqxmd.com/read/29546644/retreatment-efficacy-of-sofosbuvir-ombitasvir-paritaprevir-ritonavir-ribavirin-for-hepatitis-c-virus-genotype-4-patients
#15
Adel Abdel-Moneim, Alaa Aboud, Mohamed Abdel-Gabbar, Mohamed Zanaty, Mohamed Ramadan
BACKGROUND: The current standard of care for patients with chronic hepatitis C virus (HCV) infection is a combination of direct-acting antiviral agents (DAAs). However, rare clinical trials have been reported on the combination regimen of sofosbuvir (SOF) with ombitasvir, paritaprevir, and ritonavir (OBV/PTV/r) plus ribavirin (RBV) for treated patients with HCV genotype 4 (GT4) infection. AIMS: To clarify the retreatment efficacy and safety of the recent regimen, SOF with OBV/PTV/r + RBV, for chronic HCV GT4-experienced patients who failed treatment with DAA-based regimens...
May 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29530372/characteristics-and-correlates-of-sleep-duration-daytime-napping-snoring-and-insomnia-symptoms-among-0-5-million-chinese-men-and-women
#16
Yiping Chen, Christiana Kartsonaki, Robert Clarke, Yu Guo, Canqing Yu, Zheng Bian, Qilian Jiang, Shanpeng Li, Junshi Chen, Liming Li, Zhengming Chen
BACKGROUND: Inadequate sleep duration and insomnia can affect both physical and mental health. There is limited evidence, however, on characteristics and correlates of sleep patterns and insomnia in urban and rural China. METHODS: This cross-sectional study, involving 512,891 adults aged 30-79 years from ten (five urban and five rural) diverse areas in China, recorded detailed information, using interviewer-administered laptop-based questionnaires, on sleep patterns (duration, daytime napping and snoring) and insomnia symptoms...
April 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29523262/predictors-of-sleep-disordered-breathing-in-pregnancy
#17
Judette M Louis, Matthew A Koch, Uma M Reddy, Robert M Silver, Corette B Parker, Francesca L Facco, Susan Redline, Chia-Ling Nhan-Chang, Judith H Chung, Grace W Pien, Robert C Basner, William A Grobman, Deborah A Wing, Hyagriv N Simhan, David M Haas, Brian M Mercer, Samuel Parry, Daniel Mobley, Benjamin Carper, George R Saade, Frank P Schubert, Phyllis C Zee
BACKGROUND: Sleep-disordered breathing (SDB) is common in pregnancy, but there are limited data on predictors. OBJECTIVES: The objective of this study was to develop predictive models of sleep-disordered breathing during pregnancy. STUDY DESIGN: Nulliparous women completed validated questionnaires to assess for symptoms related to snoring, fatigue, excessive daytime sleepiness, insomnia, and restless leg syndrome. The questionnaires included questions regarding the timing of sleep and sleep duration, work schedules (eg, shift work, night work), sleep positions, and previously diagnosed sleep disorders...
February 2, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29522222/altered-diurnal-states-in-insomnia-reflect-peripheral-hyperarousal-and-metabolic-desynchrony-a-preliminary-study
#18
Philip Gehrman, Arjun Sengupta, Elizabeth Harders, Er Ubeydullah, Allan I Pack, Aalim Weljie
Study Objectives: Insomnia is a common sleep disorder that is associated with a range of adverse outcomes. Patients with insomnia exhibit hyperarousal in multiple domains, including an elevated metabolic rate, but specific metabolic molecular perturbations are unknown. Furthermore, objective clinical markers of insomnia are not available and current assessment of pathological extent relies on self-report. Here, we provide preliminary evidence that chronic insomnia is remarkably reflected in the periphery through detailed metabolic assessments...
March 7, 2018: Sleep
https://www.readbyqxmd.com/read/29522186/assessment-of-sympathetic-neural-activity-in-chronic-insomnia-evidence-for-elevated-cardiovascular-risk
#19
Jason R Carter, Daniela Grimaldi, Ida T Fonkoue, Lisa Medalie, Babak Mokhlesi, Eve Van Cauter
Study Objectives: Chronic insomnia affects up to 15% of adults. Recent cross-sectional and prospective epidemiological studies report an association between insomnia and hypertension, including incident hypertension, yet mechanisms underlying the association remain unknown. We hypothesized that subjects with chronic insomnia would have elevated sympathetic neural outflow, blunted baroreflex sensitivity, and augmented sympathetic neural and cardiovascular reactivity to stress when compared to good-sleeper controls...
March 7, 2018: Sleep
https://www.readbyqxmd.com/read/29513688/relationship-between-sleep-quality-and-dizziness
#20
Sung Kyun Kim, Ji Hoon Kim, Seung Sik Jeon, Seok Min Hong
OBJECTIVE: Poor sleep quality has a number of significant negative effects on daytime function. However, few studies have examined sleep quality in patients with dizziness. Here, we investigated the potential association between sleep quality and various types of dizziness. SUBJECTS AND METHODS: We examined dizziness and sleep disturbance in 237 patients experiencing dizziness using Korean versions of the Pittsburgh Sleep Quality Index (PSQI), the Insomnia Severity Index (ISI), and Dizziness Handicap Inventory (DHI)...
2018: PloS One
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