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https://www.readbyqxmd.com/read/29217495/efficacy-of-violet-oil-a-traditional-iranian-formula-in-patients-with-chronic-insomnia-a-randomized-double-blind-placebo-controlled-study
#1
Zohre Feyzabadi, Fariborz Rezaeitalab, Shapour Badiee, Ali Taghipour, Fatemeh Moharari, Atefeh Soltanifar, Mohammad Reza Ahmadpour
ETHNOPHARMACOLOGICAL RELEVANCE: Violet oil is an ancient herbal drug which has been extensively used to treat insomnia in traditional Iranian Medicine clinics. Violet oil is an almond or sesame oil-based extract of Viola odorata, which is administered as nasal drops. This study aimed to evaluate the efficacy of Violet oil in the treatment of insomnia. METHODS AND MATERIALS: This study was conducted as a 3-arm double-blind randomized trial. A total of 75 patients with chronic insomnia were enrolled and randomly assigned to three groups in Traditional Iranian Medicine Clinic of Mashhad University of Medical Sciences, Mashhad, Iran...
December 4, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29212081/in-patients-with-chronic-kidney-disease-short-term-blood-pressure-variability-is-associated-with-the-presence-and-severity-of-sleep-disorders
#2
Martino F Pengo, Donatella Ioratti, Valeria Bisogni, Verdiana Ravarotto, Barbara Rossi, Luciana Bonfante, Francesca Simioni, Federico Nalesso, Giuseppe Maiolino, Lorenzo A Calò
BACKGROUND/AIMS: In chronic kidney disease (CKD) patients blood pressure variability (BPV) is associated with poor outcome. Sleep disturbances alter BP profiles in hypertensives but their influence on BPV in CKD patients is unknown. We screened a cohort of CKD/ESRD patients to investigate whether sleep quality impacts on BPV. METHODS: Consecutive CKD patients' sleep quality was assessed using validated questionnaires (Epworth Sleepiness Scale-ESS); International Restless legs scale-IRLS; Functional Outcomes of Sleep Questionnaire-FOSQ: Insomnia Severity Index-ISI; STOP-Bang)...
November 28, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29180102/insomnia-in-united-states-military-veterans-an-integrated-theoretical-model
#3
REVIEW
Jaime M Hughes, Christi S Ulmer, Jennifer M Gierisch, S Nicole Hastings, Matthew O Howard
Marked by difficulty falling or staying asleep and/or poor sleep leading to daytime dysfunction, insomnia contributes to functional impairment, poor health, and increased healthcare utilization when left untreated. As many as two-thirds of Iraq and Afghanistan military veterans complain of insomnia. Older veterans of prior conflicts report insomnia occurring since initial service, suggesting a chronic nature to insomnia in this population. Despite insomnia's high prevalence and severe consequences, there is no theoretical model to explain either the onset or chronicity of insomnia in this growing patient population...
November 20, 2017: Clinical Psychology Review
https://www.readbyqxmd.com/read/29178164/issues-and-challenges-in-implementing-clinical-practice-guideline-for-the-management-of-chronic-insomnia
#4
EDITORIAL
Charles M Morin
No abstract text is available yet for this article.
December 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/29168225/gaba-modulating-phytomedicines-for-anxiety-a-systematic-review-of-preclinical-and-clinical-evidence
#5
REVIEW
Karen Savage, Joseph Firth, Con Stough, Jerome Sarris
Anxiety disorders are chronic and functionally disabling conditions with high psychological stress, characterised by cognitive symptoms of excessive worry and focus difficulties and physiological symptoms such as muscle tension and insomnia. Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter within the central nervous system and is a key target of pharmacotherapies in the treatment of anxiety. Although current pharmaceutical treatments are often efficacious, they may cause undesirable side effects including cognitive decrements and withdrawal symptoms...
November 23, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29164561/study-of-prevalence-and-influencing-factors-of-depression-in-tumor-patients-and-the-therapeutic-effects-of-fluoxetine
#6
J Dai, N Liao, J Shi, J-Q Tao
OBJECTIVE: To observe the depression in patients with malignant tumor and influencing factors of the disease, as well as to investigate the effects of fluoxetine on depressive symptoms in cancer patients and the immune function. PATIENTS AND METHODS: 262 patients with malignant tumors, confirmed by pathological and radiological diagnosis as malignant tumor were randomly divided into 2 groups: the control group with chemotherapy; the treatment group with chemotherapy and 20 mg/d fluoxetine for six weeks...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29157588/sleep-spindles-may-predict-response-to-cognitive-behavioral-therapy-for-chronic-insomnia
#7
Thien Thanh Dang-Vu, Benjamin Hatch, Ali Salimi, Melodee Mograss, Soufiane Boucetta, Jordan O'Byrne, Marie Brandewinder, Christian Berthomier, Jean-Philippe Gouin
BACKGROUND: While cognitive-behavioral therapy for insomnia constitutes the first-line treatment for chronic insomnia, only few reports have investigated how sleep architecture relates to response to this treatment. In this pilot study, we aimed to determine whether pre-treatment sleep spindle density predicts treatment response to cognitive-behavioral therapy for insomnia. METHODS: Twenty-four participants with chronic primary insomnia participated in a 6-week cognitive-behavioral therapy for insomnia performed in groups of 4-6 participants...
November 2017: Sleep Medicine
https://www.readbyqxmd.com/read/29156690/abnormal-amplitude-of-low-frequency-fluctuations-associated-with-rapid-eye-movement-in-chronic-primary-insomnia-patients
#8
Qian Ran, Jia Chen, Chuan Li, Li Wen, Faguo Yue, Tongsheng Shu, Jianxun Mi, Guangxian Wang, Lei Zhang, Dong Gao, Dong Zhang
Purpose: Chronic primary insomnia (CPI) is the most prevalent sleep disorder worldwide. CPI manifests as difficulties in sleep onset, maintaining sleep, prolonged sleep latency, and daytime impairment and is often accompanied by cognitive problems such as poor academic performance, poor attention, and decreased memory. The most popular explanation of insomnia is hyperarousal or increased activities of neurons. Rapid eye movement (REM) sleep detected by polysomnography (PSG) exhibits a positive relationship with brain homeostasis and can be helpful for optimally preparing an organism for emotional and social function...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29127459/the-use-of-an-electronic-clinical-rule-to-discontinue-chronically-used-benzodiazepines-and-related-z-drugs
#9
C Mestres Gonzalvo, V Milosevic, B P C van Oijen, H A J M de Wit, K P G M Hurkens, W J Mulder, R Janknegt, J M G A Schols, F R Verhey, B Winkens, P H M van der Kuy
PURPOSE: The chronic use of benzodiazepines and benzodiazepine-related drugs (BZ/Z) in older people is common and not without risks. The objective of this study was to evaluate whether the implementation of a clinical rule promotes the discontinuation of chronically used BZ/Z for insomnia. METHODS: A clinical rule, generating an alert in case of chronic BZ/Z use, was created and applied to the nursing home (NH) setting. The clinical rule was a one-off intervention, and alerts did not occur over time...
November 10, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29111466/anxiety-and-insomnia-in-young-and-middle-aged-adult-hip-pain-patients-with-and-without-femoroacetabular-impingement-and-developmental-hip-dysplasia
#10
Heidi Prather, Andrew Creighton, Chris Sorenson, Scott Simpson, Maria Reese, Devyani Hunt, Monica Rho
BACKGROUND: Hip pain in young and middle- aged adults with and without hip deformity receive treatment focused primarily related to hip structure. Because their hip pain may be chronic, these patients develop other modifiable co-existing disorders related to pain that go undiagnosed in this young and active population including insomnia and anxiety. OBJECTIVE: The objective is to compare assessments of insomnia and anxiety in young and middle-aged adults presenting with hip pain with no greater than minimal osteoarthritis (OA) compared to asymptomatic (healthy) controls...
October 27, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29106763/higher-prevalence-and-increased-severity-of-sleep-disordered-breathing-in-male-patients-with-chronic-tinnitus-our-experience-with-173-cases
#11
Jen-Tsung Lai, Ping-Hung Shen, Che-Yang Lin, Chun-Lin Liu, Tien-Chen Liu
Tinnitus and sleep are closely related. One of the most important aspects of tinnitus is its association with sleep disturbance. According to the literature, up to 71% of patients with tinnitus report sleep problems (1); furthermore, insomnia is also associated with more distressing tinnitus (2). Conversely, sleep disturbance was proposed as one of the causes of chronic tinnitus (3). The relationship of tinnitus with sleep-disordered breathing (SDB) and obstructive sleep apnea (OSAS) has rarely been mentioned (4)...
November 6, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29104908/stress-and-sleep-results-from-the-hispanic-community-health-study-study-of-latinos-sociocultural-ancillary-study
#12
Carmela Alcántara, Sanjay R Patel, Mercedes Carnethon, Sheila Castañeda, Carmen R Isasi, Sonia Davis, Alberto Ramos, Elva Arredondo, Susan Redline, Phyllis C Zee, Linda C Gallo
Hispanics/Latinos face specific sociocultural stressors associated with their marginalized status in the United States. While stress is known to cause poor sleep, the differential effects of the specific stressors faced by Hispanics/Latinos have not been evaluated. Using cross-sectional data from the Hispanic Community Health Study/Study of Latinos Sociocultural Ancillary Study, we conducted weighted generalized linear models to evaluate the associations of acculturation stress, ethnic discrimination, and chronic moderate/severe stress with self-reported sleep outcomes (insomnia symptoms, daytime sleepiness, sleep duration) in individual and aggregate models adjusted for site, socio-demographics, behavioral, and medical conditions...
December 2017: SSM—Population Health
https://www.readbyqxmd.com/read/29080688/low-serum-25-hydroxyvitamin-d-concentrations-in-chronic-insomnia-patients-and-the-association-with-poor-treatment-outcome-at-2months
#13
Kai Zhao, Xiaoqian Luan, Yuntao Liu, Xinjie Tu, Huijun Chen, Huiping Shen, Huihua Qiu, Zhuoying Zhu, Jincai He
BACKGROUND: The association between low 25-hydroxyvitamin D [25(OH)D] and sleep disorder has been reported. We investigated whether serum concentrations of 25(OH)D are altered in chronic insomnia patients. The relationship between serum concentrations of 25(OH)D and the treatment outcome in patients at 2months was also investigated. METHODS: In total, 181 chronic insomnia patients were consecutively recruited. All patients received pharmacotherapy for the treatment of chronic insomnia...
October 26, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29077623/internet-based-exposure-therapy-for-fibromyalgia-a-randomized-controlled-trial
#14
Maria Hedman-Lagerlöf, Erik Hedman-Lagerlöf, Erland Axelsson, Brjánn Ljótsson, Johanna Engelbrektsson, Sofia Hultkrantz, Karolina Lundbäck, Daniel Björkander, Rikard Wicksell, Ida Flink, Erik Andersson
Fibromyalgia (FM) is a common and disabling chronic pain disorder, for which existing pharmacological and psychological treatments have yet yielded insufficient effects. Previous literature has shown that exposure therapy may be an effective treatment for chronic pain. This study constitutes the first randomized controlled trial evaluating exposure therapy for FM. One hundred and forty participants with diagnosed FM were randomized to a 10-week internet-based exposure treatment (iExp; n=70) or a waitlist control condition (WLC; n=70)...
October 26, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/29069319/sex-specific-associations-of-different-anthropometric-indices-with-acute-and-chronic-insomnia
#15
Valentina A Andreeva, Marion J Torres, Nathalie Druesne-Pecollo, Damien Léger, Paloma Gonzalez, Virginie Bayon, Serge Hercberg, Pilar Galan
Background: Sleep disorders, including insomnia, are risk factors for weight gain. However, few epidemiological studies have investigated the association of anthropometric markers with insomnia as an outcome. Methods: In this observational, cross-sectional study, we assessed the association of 3 different anthropometric indices with acute and chronic insomnia. We used data from 13 389 French adults (mean age= 51.9 ± 13.1 years; 70.3% women) enrolled in the NutriNet-Santé-Biobank cohort...
October 23, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/29065953/lemborexant-a-dual-orexin-receptor-antagonist-dora-for-the-treatment-of-insomnia-disorder-results-from-a-bayesian-adaptive-randomized-double-blind-placebo-controlled-study
#16
Patricia Murphy, Margaret Moline, David Mayleben, Russell Rosenberg, Gary Zammit, Kate Pinner, Shobha Dhadda, Quan Hong, Luigi Giorgi, Andrew Satlin
STUDY OBJECTIVES: To identify dose(s) of lemborexant that maximize insomnia treatment efficacy while minimizing next-morning residual sleepiness and evaluate lemborexant effects on polysomnography (PSG) measures (sleep efficiency [SE], latency to persistent sleep [LPS], and wake after sleep onset [WASO]) at the beginning and end of treatment. METHODS: Adults and elderly subjects with insomnia disorder per the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition were enrolled in a multicenter, randomized, double-blind, placebo-controlled, Bayesian, adaptive, parallel-group study, receiving lemborexant (1, 2...
November 15, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29058361/pain-remission-at-one-year-follow-up-with-spinal-cord-stimulation
#17
Hirah Khan, Julie G Pilitsis, Julia Prusik, Heather Smith, Sarah E McCallum
OBJECTIVES: Spinal Cord Stimulation (SCS) is an effective treatment for chronic pain. How often pain remission follows SCS has not been evaluated. This is a retrospective analysis of patients who underwent an implantation of spinal cord stimulators for various chronic pain conditions. The objective of the study was to elucidate characteristics and features of patients with pain relief greater than 80% after one year of treatment. METHODS: A total of 86 patients with thoracic SCS and 12-month follow-up data were identified...
October 23, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29057368/intervention-development-for-the-indicated-prevention-of-depression-in-later-life-the-dil-protocol-in-goa-india
#18
Amit Dias, Fredric Azariah, Public Health, Alex Cohen, Stewart Anderson, Jennifer Morse, Pim Cuijpers, Miriam Sequeira, M A Psychology, Vithoba Gaude, Salvino Soares, Vikram Patel, Charles F Reynolds
Because depression is a major source of the global burden of illness- related disability, developing effective strategies for reducing its incidence is an important public health priority, especially in low-income countries, where resources for treating depression are scarce. We describe in this report an intervention development project, funded by the US National Institute of Mental Health, to address "indicated" prevention of depression in older adults attending rural and urban primary care clinics in Goa, India...
June 2017: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/29057261/aprepitant-for-the-treatment-of-chronic-refractory-pruritus
#19
REVIEW
Alice He, Jihad M Alhariri, Ronald J Sweren, Madan M Kwatra, Shawn G Kwatra
Chronic pruritus is a difficult condition to treat and is associated with several comorbidities, including insomnia, depression, and decreased quality of life. Treatment for chronic itch includes corticosteroids, antihistamines, and systemic therapies such as naltrexone, gabapentin, UV light therapy, and immunomodulatory treatments, including azathioprine, methotrexate, and cellcept. However, some patients still remain refractory to conventional therapy. Aprepitant is a neurokinin-1 receptor antagonist approved for the prevention of chemotherapy-induced and postoperative nausea and vomiting (CINV, PONV)...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29034538/association-of-insomnia-severity-with-well-being-quality-of-life-and-health-care-costs-a-cross-sectional-study-in-older-adults-with-chronic-pain-pains65
#20
E Dragioti, L Bernfort, B Larsson, B Gerdle, L Å Levin
BACKGROUND: Insomnia is one of the most common complaints in chronic pain. This study aimed to evaluate the association of insomnia with well-being, quality of life and health care costs. METHODS: The sample included 2790 older individuals (median age = 76; interquartile range [IQR] = 70-82) with chronic pain. The participants completed a postal survey assessing basic demographic data, pain intensity and frequency, height, weight, comorbidities, general well-being, quality of life and the insomnia severity index (ISI)...
October 16, 2017: European Journal of Pain: EJP
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