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REVIEW
Peeraporn Varinthra, Shameemun Naseer Mohamed Nizarul Anwar, Shu-Ching Shih, Ingrid Y Liu
Sleep is an essential activity for the survival of mammals. Good sleep quality helps promote the performance of daily functions. In contrast, insufficient sleep reduces the efficiency of daily activities, causes various chronic diseases like Alzheimer's disease, and increases the risk of having accidents. The GABAergic system is the primary inhibitory neurotransmitter system in the central nervous system. It transits the gamma-aminobutyric acid (GABA) neurotransmitter via GABAA and GABAB receptors to counterbalance excitatory neurotransmitters, such as glutamate, noradrenaline, serotonin, acetylcholine, orexin, and dopamine, which release and increase arousal activities during sleep...
2024: Tzu chi medical journal
#2
JOURNAL ARTICLE
Tobias Di Marco, Ina Djonlagic, Yves Dauvilliers, Kolia Sadeghi, David Little, Alexandre N Datta, Jeffrey Hubbard, Göran Hajak, Andrew Krystal, Antonio Olivieri, Liborio Parrino, Corey B Puryear, Gary Zammit, Jacob Donoghue, Thomas E Scammell
STUDY OBJECTIVES: Post-hoc analysis to evaluate the effect of daridorexant on sleep architecture in people with insomnia, focusing on features associated with hyperarousal. METHODS: We studied sleep architecture in adults with chronic insomnia disorder from two randomized Phase 3 clinical studies (Clinicaltrials.gov: NCT03545191 and NCT03575104) investigating 3 months of daridorexant treatment (placebo, daridorexant 25 mg, daridorexant 50 mg). We analyzed sleep-wake transition probabilities, EEG spectra and sleep spindle properties including density, dispersion, and slow oscillation phase coupling...
April 22, 2024: Sleep
#3
JOURNAL ARTICLE
Julie Garrivet, Bénédicte Gohier, Gabriel Laviole, Nicole Meslier, Frédéric Gagnadoux, Wojciech Trzepizur
BACKGROUND: Sleep disorders and psychiatric disorders stand in a bidirectional relationship. Sleep complaints are prominent in populations with psychiatric disorders, especially amongst people with major depressive disorder (MDD) and post-traumatic stress disorder (PTSD). Consultations at sleep clinics offer opportunities to screen psychiatric disorders and to propose primary psychiatric care. METHODS: This descriptive study was conducted on 755 patients making their first visit to sleep clinic, with 574 seeking consultation for suspected obstructive sleep apnoea-hypopnoea syndrome (OSAHS), 139 for complaints of insomnia, and 42 for complaints of hypersomnia...
April 15, 2024: Sleep Medicine
#4
JOURNAL ARTICLE
Qi-Yu Chen, Min Zhuo
Insomnia is an important comorbidity of chronic pain. In this issue of Neuron, Li et al. report that chronic-pain-induced insomnia is mediated by the pyramidal neurons in the anterior cingulate cortex and their dopaminergic projections to the dorsal medial striatum.
April 17, 2024: Neuron
#5
JOURNAL ARTICLE
Caroline Mann, Matthias Dreher, Jan-Niklas Rothschmidt, Petra Staubach
INTRODUCTION: Patients with chronic inflammatory skin diseases often suffer from sleep disturbances. However, objective data on sleep architecture, especially to evaluate potential overall influences under therapy, are lacking. PATIENTS AND METHODS: Pilot study on sleep quality changes including psoriasis and atopic dermatitis patients before and 2 weeks after intensive topical treatment. In addition to disease activity rating, patient-rated outcomes for itch severity and sleep quality and polygraphy was performed before and after topical therapy...
April 18, 2024: Journal der Deutschen Dermatologischen Gesellschaft: JDDG
#6
JOURNAL ARTICLE
Masahiro Takeshima, Kazuhisa Yoshizawa, Masaya Ogasawara, Mizuki Kudo, Yu Itoh, Naoko Ayabe, Kazuo Mishima
IMPORTANCE: Although insomnia guidelines recommend the use of several individual hypnotics, the most useful hypnotic for treating insomnia in a clinical setting remains unclear. OBJECTIVE: To determine which guideline-recommended hypnotics have lower risks of monotherapy failure and which hypnotics have a higher risk of long-term prescription for insomnia treatment. DESIGN, SETTING, AND PARTICIPANTS: This retrospective observational cohort study used data from the Japan Medical Data Center Claims Database from April 1, 2005, to March 31, 2021...
April 1, 2024: JAMA Network Open
#7
RANDOMIZED CONTROLLED TRIAL
Yi Liu, Hui Feng, Zhenghe Yu, Chuanlong Zhou, Guanglie Chen, Youdan Wei
OBJECTIVES: To observe the efficacy of acupuncture for reducing the south to reinforce the north on executive function, sleep structure and sleep quality in patients with chronic insomnia disorder of heart-kidney disharmony. METHODS: A total of 100 patients with chronic insomnia disorder of heart-kidney disharmony were randomized into an acupuncture group (50 cases, 1 case dropped out) and a western medication group (50 cases, 2 cases dropped out). Acupuncture for reducing the south to reinforce the north was applied at Baihui (GV 20) and bilateral Shenmen (HT 7), Sanyinjiao (SP 6), Shenmai (BL 62), Zhaohai (KI 6), Xinshu (BL 15), Shenshu (BL 23) in the acupuncture group, once a day, 5 days a week...
April 12, 2024: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
#8
JOURNAL ARTICLE
Seong Hae Kim, Bo Young Jeong, Young Sun Kim, Ji Woon Park
BACKGROUND: The Coronavirus 2019 disease (COVID-19) caused drastic changes in people's lifestyle that affected TMD characteristics through its physical and psychological influences. The aim of this study was to define the clinical and psychological characteristics of a large group of well-defined TMD patients and seek their differences between before and during the COVID-19 pandemic to establish points of care to be emphasized in the post-pandemic era. METHODS: TMD patients diagnosed by the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) aged ≥ 18 were analyzed...
April 12, 2024: BMC Oral Health
#9
JOURNAL ARTICLE
Qiang Chen, Xinru Chen, Yuqing Zhu, Xiali Yu
RATIONALE: This report presents a unique case of a patient diagnosed with Primary Sjögren's syndrome and a relatively rare traditional Chinese medicine pattern, known as the combined cold and heat pattern and cold-dampness syndrome. The patient's condition was successfully managed using Chinese herbal medicine, specifically the modified Da-Chai-Hu decoction and Linggui Zhugan decoction. PATIENT CONCERNS: A 56-year-old woman had chronic dry eye and mouth for over 10 years...
April 12, 2024: Medicine (Baltimore)
#10
JOURNAL ARTICLE
Jiaying Li, Daniel Yee Tak Fong, Kris Yuet Wan Lok, Janet Yuen Ha Wong, Mandy Man Ho, Edmond Pui Hang Choi, Vinciya Pandian, Patricia M Davidson, Wenjie Duan, Marie Tarrant, Jung Jae Lee, Chia-Chin Lin, Oluwadamilare Akingbade, Khalid M Alabdulwahhab, Mohammad Shakil Ahmad, Mohamed Alboraie, Meshari A Alzahrani, Anil S Bilimale, Sawitree Boonpatcharanon, Samuel Byiringiro, Muhammad Kamil Che Hasan, Luisa Clausi Schettini, Walter Corzo, Josephine M De Leon, Anjanette S De Leon, Hiba Deek, Fabio Efficace, Mayssah A El Nayal, Fathiya El-Raey, Eduardo Ensaldo-Carrasco, Pilar Escotorin, Oluwadamilola Agnes Fadodun, Israel Opeyemi Fawole, Yong-Shian Shawn Goh, Devi Irawan, Naimah Ebrahim Khan, Binu Koirala, Ashish Krishna, Cannas Kwok, Tung Thanh Le, Daniela Giambruno Leal, Miguel Ángel Lezana-Fernández, Emery Manirambona, Leandro Cruz Mantoani, Fernando Meneses-González, Iman Elmahdi Mohamed, Madeleine Mukeshimana, Chinh Thi Minh Nguyen, Huong Thi Thanh Nguyen, Khanh Thi Nguyen, Son Truong Nguyen, Mohd Said Nurumal, Aimable Nzabonimana, Nagla Abdelrahim Mohamed Ahmed Omer, Oluwabunmi Ogungbe, Angela Chiu Yin Poon, Areli Reséndiz-Rodriguez, Busayasachee Puang-Ngern, Ceryl G Sagun, Riyaz Ahmed Shaik, Nikhil Gauri Shankar, Kathrin Sommer, Edgardo Toro, Hanh Thi Hong Tran, Elvira L Urgel, Emmanuel Uwiringiyimana, Tita Vanichbuncha, Naglaa Youssef
BACKGROUND: Central and bridge nodes can drive significant overall improvements within their respective networks. We aimed to identify them in 16 prevalent chronic diseases during the coronavirus disease 2019 (COVID-19) pandemic to guide effective intervention strategies and appropriate resource allocation for most significant holistic lifestyle and health improvements. METHODS: We surveyed 16 512 adults from July 2020 to August 2021 in 30 territories. Participants self-reported their medical histories and the perceived impact of COVID-19 on 18 lifestyle factors and 13 health outcomes...
April 12, 2024: Journal of Global Health
#11
JOURNAL ARTICLE
Yixian Cai, Di Gong, Ting Xiang, Xiaotao Zhang, Jiyang Pan
OBJECTIVE: Insomnia disorder stands out as one of the prevalent clinical sleep and psychiatric disorders. Prior research has unequivocally demonstrated variations in the diversity and abundance of gut microbiota among individuals with insomnia disorder. These alterations may play a direct or indirect role in the onset and progression of insomnia disorder by compromising the integrity of the intestinal barrier. This study aims to evaluate the impairment of the intestinal barrier in individuals with insomnia disorder by scrutinizing the serum functionality of this barrier...
2024: Frontiers in Psychiatry
#12
JOURNAL ARTICLE
Keisuke Suzuki, Shiho Suzuki, Yasuo Haruyama, Kei Funakoshi, Hiroaki Fujita, Hirotaka Sakuramoto, Mai Hamaguchi, Gen Kobashi, Koichi Hirata
OBJECTIVE: Sleep disturbances are common in migraine patients and affect quality of life. Central sensitization (CS) is likely to play a role in the increased severity and chronicity of migraine. We hypothesized that the number of comorbid sleep problems would affect headache-related disability through the effects of central sensitization (CS). METHODS: We performed a cross-sectional study including 215 consecutive patients with migraine. Insomnia was defined as a Pittsburgh Sleep Quality Index (PSQI) global score greater than 5...
2024: Frontiers in Neurology
#13
JOURNAL ARTICLE
Shinwon Lee, Soyoon Hwang, Ki Tae Kwon, EunKyung Nam, Un Sun Chung, Shin-Woo Kim, Hyun-Ha Chang, Yoonjung Kim, Sohyun Bae, Ji-Yeon Shin, Sang-Geun Bae, Hyun Wook Ryoo, Juhwan Jeong, NamHee Oh, So Hee Lee, Yeonjae Kim, Chang Kyung Kang, Hye Yoon Park, Jiho Park, Se Yoon Park, Bongyoung Kim, Hae Suk Cheong, Ji Woong Son, Su Jin Lim, Seongcheol Yun, Won Sup Oh, Kyung-Hwa Park, Ju-Yeon Lee, Sang Taek Heo, Ji-Yeon Lee
BACKGROUND: A healthcare system's collapse due to a pandemic, such as the coronavirus disease 2019 (COVID-19), can expose healthcare workers (HCWs) to various mental health problems. This study aimed to investigate the impact of the COVID-19 pandemic on the depression and anxiety of HCWs. METHODS: A nationwide questionnaire-based survey was conducted on HCWs who worked in healthcare facilities and public health centers in Korea in December 2020. Patient Health Questionnaire-9 (PHQ-9) and Generalized Anxiety Disorder-7 (GAD-7) were used to measure depression and anxiety...
April 8, 2024: Journal of Korean Medical Science
#14
(no author information available yet)
[This corrects the article DOI: 10.2147/NSS.S396773.].
2024: Nature and Science of Sleep
#15
JOURNAL ARTICLE
Zosia Goossens, Thomas Bilterys, Eveline Van Looveren, Anneleen Malfliet, Mira Meeus, Lieven Danneels, Kelly Ickmans, Barbara Cagnie, Aurore Roland, Maarten Moens, Jo Nijs, Liesbet De Baets, Olivier Mairesse
(1) Background : This exploratory study aims to explore the relationship between nonspecific chronic spinal pain (nCSP) and insomnia symptoms, by examining the interconnections, strengths, and directional dependence of the symptoms. In addition, we aim to identify the key symptoms of the nCSP-insomnia relationship and shed light on the bidirectional nature of this relationship. (2) Methods : This study is a secondary analysis of the baseline data (cross-sectional) from a randomized controlled trial, which examined the added value of Cognitive Behavioral Therapy for Insomnia (CBT-I) combined with cognition-targeted exercise therapy, conducted in collaboration with the Universiteit Gent and Vrije Universiteit Brussel (Belgium)...
March 2, 2024: Journal of Clinical Medicine
#16
JOURNAL ARTICLE
Sabbu Maharjan, Ruchi Dua, Lokesh Kumar Saini, Niraj Kumar, Ravi Gupta
BACKGROUND: Patients having COPD share some factors, e.g., chronic hypoxemia, anemia of chronic disease and nicotine use, which are also the risk factors for RLS hence predispose them to experience RLS in higher then general population. There are limited studies with methodological constraints evaluating the prevalence and/or correlates of RLS among patients with COPD. METHODS: Consecutive adult patients of either gender, having stable COPD as per GOLD guidelines 2021, were assessed for RLS using IRLSSG (2014) criteria (excluding RLS mimics) and the severity of RLS was determined in participants having RLS...
April 4, 2024: Sleep Medicine
#17
JOURNAL ARTICLE
Chenhui Du, Rui Han, Jiang Wu, Ni Zhao, Xiangping Pei, Xuemei Qin, Yan Yan
Ziziphi Spinosae Semen (ZSS) and fried ZSS (FZSS) have been used for treating insomnia and depression in China. However, the potential influence of chemical variations on their efficacy remains unclear. This study demonstrated that compared with ZSS, FZSS exhibited an increase in the content of seven compounds, while the fatty oil content decreased. Both ZSS and FZSS exhibited antidepressive effects in a chronic unpredictable mild stress rat model, indicating a synergistic regulation of deficiencies in 5-hydroxytryptamine in the brain and the hyperactivation of severe peripheral inflammation...
April 8, 2024: Biomedical Chromatography: BMC
#18
JOURNAL ARTICLE
Yan Wang, Kendall R Robinson, Hannah Fechtel, Alexis Hartog
PURPOSE OF REVIEW: With the rapidly changing landscape of state level legalization of cannabis, older adults have become one of the fastest growing populations seeking medical cannabis (MC). However, research evidence on the risks and benefits of MC use in this population remains limited. This review aims to synthesize recent literature on the impacts of MC use in older adults and identify critical knowledge gaps to be addressed in future research. RECENT FINDINGS: Recent literature showed that older adults often face financial and/or educational barriers and stigma associated with MC access...
December 2023: Current Addiction Reports
#19
REVIEW
Geert Mayer, Helmut Frohnhofen, Martha Jokisch, Dirk M Hermann, Janine Gronewold
Due to worldwide demographic change, the number of older persons in the population is increasing. Aging is accompanied by changes of sleep structure, deposition of beta-amyloid (Aß) and tau proteins and vascular changes and can turn into mild cognitive impairment (MCI) as well as dementia. Sleep disorders are discussed both as a risk factor for and as a consequence of MCI/dementia. Cross-sectional and longitudinal population-based as well as case-control studies revealed sleep disorders, especially sleep-disorderded breathing (SDB) and excessive or insufficient sleep durations, as risk factors for all-cause MCI/dementia...
2024: Frontiers in Neuroscience
#20
JOURNAL ARTICLE
Woo-Ju Kim, Ho-Sook Kim
Insomnia, commonly treated with benzodiazepine (BZD) receptor agonists, presents challenges due to associated serious side effects such as abuse and dependence. To address these concerns, many researches have been conducted to develop and advance both pharmacological and non-pharmacological interventions. Dual orexin receptor antagonists (DORAs), which include suvorexant, daridorexant and lemborexant, have recently been approved by United States Food and Drug Administration (US FDA) as a novel pharmacotherapeutic alternative...
March 2024: Translational and clinical pharmacology
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