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https://www.readbyqxmd.com/read/28435984/patterns-predictors-and-persistence-of-chronic-sedative-use-a-population-based-observational-study-of-older-adults-in-british-columbia-canada
#1
Steven G Morgan, Deirdre Weymann
BACKGROUND: Benzodiazepines and benzodiazepine-like sedatives (zopiclone, zolpidem and zaleplon) are commonly prescribed to treat anxiety and insomnia but are contraindicated for chronic use. We sought to study the persistence, over multiple years, of chronic use of benzodiazepines and benzodiazepine-like sedatives among community-dwelling adults in British Columbia, Canada. METHODS: This is a retrospective analysis of linked health data for adults aged 50 to 69 in 2004 who resided in British Columbia, Canada, between 2004 and 2013...
April 24, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28432269/altered-sleep-patterns-in-patients-with-non-functional-ghrh-receptor
#2
Francielle T Oliveira, Roberto Salvatori, Jose' Marcondes, Larissa B Macena, Alecia A Oliveira-Santos, Augusto Cn Faro, Viviane C Campos, Carla R Oliveira, Ursula Mm Costa, Manuel Aguiar-Oliveira
OBJECTIVES: GH releasing hormone (GHRH) exerts hypnotic actions increasing non-rapid eye movement (NREM) sleep. Conversely, GH stimulates REM sleep. GH deficiency (GHD) often leads to sleep problems, daytime fatigue, and reduced quality of life (QoL). GHD may be due to lack of hypothalamic GHRH or destruction of somatotroph cells. We have described a cohort with isolated GHD (IGHD) due to GHRH resistance caused by a homozygous null mutation in the GHRH receptor gene. They have normal QoL and no obvious complaints of chronic tiredness...
April 21, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28424378/-recognition-care-and-prevention-of-suicidal-behaviour-in-adults
#3
Zoltán Rihmer, Attila Németh, Tamás Kurimay, Dóra Perczel-Forintos, György Purebl, Péter Döme
Suicide is a major public health problem everywhere in the world and in the WHO European Region suicide accounts for over 120,000 deaths per year. 1. Recognition and diagnosis: An underlying psychiatric disorder is present in up to 90% of people who completed suicide. Comorbidity with depression, anxiety, substance abuse and personality disorders is high. In order to achieve successful prevention of suicidality, adequate diagnostic procedures and appropriate treatment for the underlying disorder are essential...
2017: Psychiatria Hungarica: A Magyar Pszichiátriai Társaság Tudományos Folyóirata
https://www.readbyqxmd.com/read/28418328/internet-based-intervention-for-tinnitus-outcome-of-a-single-group-open-trial
#4
Eldré W Beukes, Peter M Allen, Vinaya Manchaiah, David M Baguley, Gerhard Andersson
BACKGROUND: Managing chronic tinnitus is challenging, and innovative ways to address the resulting health-care burden are required. Internet-based cognitive behavioral therapy (iCBT) for tinnitus shows promise as a cost-effective treatment option. The feasibility and effectiveness of iCBT in the United Kingdom are yet to be explored. Furthermore, it is not known if iCBT can be supported by an audiologist rather than a psychologist. PURPOSE: This study aimed to determine the feasibility of guided iCBT using audiological support on tinnitus distress and tinnitus-related comorbidities...
April 2017: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/28404069/patient-reported-outcomes-with-sofosbuvir-and-velpatasvir-with-or-without-ribavirin-for-hepatitis-c-virus-related-decompensated-cirrhosis-an-exploratory-analysis-from-the-randomised-open-label-astral-4-phase-3-trial
#5
Zobair M Younossi, Maria Stepanova, Michael Charlton, Michael P Curry, Jacqueline G O'Leary, Robert S Brown, Sharon Hunt
BACKGROUND: Hepatitis C virus (HCV) treatment regimens with direct-acting antivirals have not been extensively studied in patients with decompensated cirrhosis. We assessed patient-reported outcomes (PROs) in patients with decompensated cirrhosis given a fixed-dose combination of sofosbuvir and velpatasvir with and without ribavirin. METHODS: This study was an exploratory analysis of data collected in a randomised, open-label phase 3 trial (ASTRAL-4) in which patients with HCV-related decompensated cirrhosis were randomly assigned to an all-oral fixed-dose combination of sofosbuvir (400 mg) and velpatasvir (100 mg) once daily for 12 weeks, sofosbuvir and velpatasvir plus oral ribavirin (weight-based 1000 mg or 1200 mg) for 12 weeks, or sofosbuvir and velpatasvir for 24 weeks...
October 2016: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28403895/electroacupuncture-for-insomnia-disorder-study-protocol-for-a-randomized-controlled-trial
#6
Sung-Phil Kim, Joo-Hee Kim, Bo-Kyung Kim, Hyeong-Jun Kim, In Chul Jung, Jung Hyo Cho, Jung-Eun Kim, Mi-Kyung Kim, O-Jin Kwon, Ae-Ran Kim, Hyo-Ju Park, Bok-Nam Seo
BACKGROUND: Insomnia is a common sleep disorder that affects many adults either transiently or chronically. The societal cost of insomnia is on the rise, while long-term use of current drug treatments can involve adverse effects. Recently, electroacupuncture (EA) has been used to treat various conditions including insomnia. The objective of this study is to provide scientific evidence for the effect and safety of using EA to treat insomnia. METHODS/DESIGN: In this multicentre, assessor-blind, three-arm, parallel-design, randomised controlled trial, 150 participants will be assigned to the EA group, the sham EA (SEA) group, or the usual care group...
April 13, 2017: Trials
https://www.readbyqxmd.com/read/28399441/sleep-architecture-in-insomniacs-with-severe-benzodiazepine-abuse
#7
Mauro Manconi, Raffaele Ferri, Silvia Miano, Michelangelo Maestri, Valentina Bottasini, Marco Zucconi, Luigi Ferini-Strambi
OBJECTIVE: Benzodiazepines (BZDs) are the most commonly prescribed compounds in insomnia. A long-term of BZDs use may cause dependence and abuse. The aim of this study was to evaluate sleep architecture and microstructure (in terms of cyclic alternating pattern - CAP - analysis and of sleep EEG power spectral analysis) in a group of long-term users of high doses of BZDs for their primary chronic insomnia. METHODS: Twenty patients consecutively admitted at the Sleep Centre for drug discontinuation and 13 matched healthy controls underwent a full nocturnal video-polysomnographic recording, after one adaptation night...
March 16, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28393336/-using-the-cognitive-behavioral-therapy-to-improve-the-mental-health-of-women-with-breast-cancer
#8
Li-Hung Lee, Yu-Ping Lai, Cheng-I Yang
Previous studies have shown that patients with breast cancer may suffer from symptoms of psychological distress, such as: depression, anxiety, insomnia, and chronic fatigue. Nurses are expected to offer physical and mental support to these patients. Cognitive behavior therapy (CBT) is commonly used in psychiatry as well as in the treatment of patients with breast cancer. CBT is believed to reduce mental distress in patients by changing their negative cognitive schema. The present article discusses the mental problems of patients with breast cancer and introduces the effects of using CBT on patients with breast cancer...
April 2017: Hu Li za Zhi the Journal of Nursing
https://www.readbyqxmd.com/read/28384462/can-a-10-minute-questionnaire-identify-significant-psychological-issues-in-patients-with-temporomandibular-joint-disease
#9
Shang-Lun Lin, Shang-Liang Wu, Hsien-Te Huang, For-Wey Lung, Tzong-Cherng Chi, Jung-Wu Yang
PURPOSES: For patients with disc displacement disorders (DDDs), psychiatric illness increases the risk of worsening postsurgical pain, postoperative delirium, postoperative incomplete recovery, and worse postoperative life quality. This study provides a fast and practical protocol to evaluate psychological conditions of patients with DDDs of the temporomandibular joint (TMJ) in clinical care. MATERIALS AND METHODS: The populations under investigation in this cross-sectional study included patients with DDD who received treatment from October 2012 through June 2016...
March 14, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28377394/efficacy-and-safety-of-suanzaoren-decoction-for-chronic-insomnia-disorder-in-adults-study-protocol-for-randomised-double-blind-double-dummy-placebo-controlled-trial
#10
Qi-Hui Zhou, Hui-Lin Wang, Xiao-Li Zhou, Meng-Bei Xu, Hong-Feng Zhang, Li-Bo Huang, Guo-Qing Zheng, Yan Lin
BACKGROUND: Insomnia disorder is defined as a combination of dissatisfaction with sleep quantity or quality and a significant negative impact on daytime functioning. Chronic insomnia disorder refers to clinical symptoms of persistent insomnia at least three nights a week for at least 3 months. Prevalence estimates of insomnia disorder range from 12% to 20% in the adult population, with approximately 50% having a chronic course. The potential side effects of hypnotic medications hinder their clinical application...
April 4, 2017: BMJ Open
https://www.readbyqxmd.com/read/28377393/does-a-brief-behavioural-intervention-delivered-by-paediatricians-or-psychologists-improve-sleep-problems-for-children-with-adhd-protocol-for-a-cluster-randomised-translational-trial
#11
E Sciberras, M Mulraney, H Heussler, N Rinehart, T Schuster, L Gold, N Hayes, H Hiscock
INTRODUCTION: Up to 70% of children with attention-deficit/hyperactivity disorder (ADHD) experience sleep problems. We have demonstrated the efficacy of a brief behavioural intervention for children with ADHD in a large randomised controlled trial (RCT) and now aim to examine whether this intervention is effective in real-life clinical settings when delivered by paediatricians or psychologists. We will also assess the cost-effectiveness of the intervention. METHODS AND ANALYSIS: Children aged 5-12 years with ADHD (n=320) are being recruited for this translational cluster RCT through paediatrician practices in Victoria and Queensland, Australia...
April 4, 2017: BMJ Open
https://www.readbyqxmd.com/read/28375394/insomnia-getting-to-the-cause-facilitating-relief
#12
REVIEW
Adam J Sorscher
Chronic insomnia is often the result of multiple underlying physiologic, psychological, and social factors. A sleep log, sleep hygiene, CBT, and medication can help.
April 2017: Journal of Family Practice
https://www.readbyqxmd.com/read/28364510/effectiveness-of-benzodiazepine-receptor-agonists-in-the-treatment-of-insomnia-an-examination-of-response-and-remission-rates
#13
Vivek Pillai, Thomas Roth, Timothy Roehrs, Kenneth Moss, Edward L Peterson, Christopher L Drake
Study objectives: To examine the real-world effectiveness of benzodiazepine receptor agonists (BzRAs) by quantifying response and remission rates in a clinical sample receiving chronic BzRA treatment for insomnia. Methods: Participants were outpatients (N = 193; 72% female; 55.2 ± 11.1 year) who had an insomnia diagnosis per medical records, and who were taking a therapeutic dose of BzRA for their insomnia. Endpoints were nocturnal sleep disturbance and Insomnia Severity Index (ISI) scores...
February 1, 2017: Sleep
https://www.readbyqxmd.com/read/28364509/dual-orexin-receptor-antagonist-almorexant-in-elderly-patients-with-primary-insomnia-a-randomized-controlled-study
#14
Thomas Roth, Jed Black, Raymond Cluydts, Pascal Charef, Marzia Cavallaro, Fabrice Kramer, Gary Zammit, James Walsh
Objective: Sleep laboratory study to determine the dose-related efficacy and safety of almorexant in elderly patients with primary chronic insomnia. Methods: Patients aged ≥65 years with primary insomnia were enrolled into a prospective, randomized, double-blind, placebo-controlled, multicenter dose-finding study with a five-period, five-way Latin square cross-over design. Patients were randomized to one of 10 unique sequences of two-night treatment with oral almorexant 25, 50, 100, or 200 mg capsules, or matching placebo...
February 1, 2017: Sleep
https://www.readbyqxmd.com/read/28364493/effects-of-melatonin-and-bright-light-treatment-in-childhood-chronic-sleep-onset-insomnia-with-late-melatonin-onset-a-randomized-controlled-study
#15
Annette van Maanen, Anne Marie Meijer, Marcel G Smits, Kristiaan B van der Heijden, Frans J Oort
Study Objectives: Chronic sleep onset insomnia with late melatonin onset is prevalent in childhood, and has negative daytime consequences. Melatonin treatment is known to be effective in treating these sleep problems. Bright light therapy might be an alternative treatment, with potential advantages over melatonin treatment. In this study, we compare the effects of melatonin and bright light treatment with a placebo condition in children with chronic sleep onset insomnia and late melatonin onset...
February 1, 2017: Sleep
https://www.readbyqxmd.com/read/28364456/insomnia-sleep-duration-depressive-symptoms-and-the-onset-of-chronic-multisite-musculoskeletal-pain
#16
Ellen Generaal, Nicole Vogelzangs, Brenda W J H Penninx, Joost Dekker
Study objective: The temporal relationships among sleep, depressive symptoms, and pain are unclear. This longitudinal study examines whether insomnia and sleep duration predict the onset of chronic multisite musculoskeletal pain over 6 years and whether this association is mediated by depressive symptoms. Methods: 1860 subjects of the Netherlands Study of Depression and Anxiety, free from chronic multisite musculoskeletal pain at baseline, were followed up for the onset of chronic multisite musculoskeletal pain over 6 years (Chronic Pain Grade Questionnaire)...
January 1, 2017: Sleep
https://www.readbyqxmd.com/read/28364426/long-term-maintenance-of-therapeutic-gains-associated-with-cognitive-behavioral-therapy-for-insomnia-delivered-alone-or-combined-with-zolpidem
#17
Simon Beaulieu-Bonneau, Hans Ivers, Bernard Guay, Charles M Morin
Study objectives: To document the long-term sleep outcomes at 12 and 24 months after patients with chronic insomnia were treated with cognitive-behavioral therapy (CBT), either singly or combined with zolpidem medication. Methods: Participants were 160 adults with chronic insomnia. They were first randomized for a six-week acute treatment phase involving CBT alone or CBT combined with nightly zolpidem, and randomized for a six-month extended treatment phase involving CBT, no additional treatment, CBT combined with zolpidem as needed, or CBT with zolpidem tapered...
March 1, 2017: Sleep
https://www.readbyqxmd.com/read/28364419/sleep-perception-and-misperception-in-chronic-cocaine-users-during-abstinence
#18
Sarah E Hodges, Brian Pittman, Peter T Morgan
Study Objectives: During abstinence, chronic cocaine users experience an objective worsening of sleep that is perceived as qualitatively improving. This phenomenon has been termed "occult insomnia." The objective of this study was to determine whether chronic cocaine users experience positive sleep state misperception during abstinence. Methods: Forty-three cocaine-dependent persons were admitted to an inpatient research facility for 12 days and 11 nights to participate in a treatment study of modafinil...
March 1, 2017: Sleep
https://www.readbyqxmd.com/read/28360539/alternative-remedies-for-insomnia-a-proposed-method-for-personalized-therapeutic-trials
#19
Kate Romero, Balaji Goparaju, Kathryn Russo, M Brandon Westover, Matt T Bianchi
Insomnia is a common symptom, with chronic insomnia being diagnosed in 5-10% of adults. Although many insomnia patients use prescription therapy for insomnia, the health benefits remain uncertain and adverse risks remain a concern. While similar effectiveness and risk concerns exist for herbal remedies, many individuals turn to such alternatives to prescriptions for insomnia. Like prescription hypnotics, herbal remedies that have undergone clinical testing often show subjective sleep improvements that exceed objective measures, which may relate to interindividual heterogeneity and/or placebo effects...
2017: Nature and Science of Sleep
https://www.readbyqxmd.com/read/28349316/cannabis-cannabinoids-and-sleep-a-review-of-the-literature
#20
REVIEW
Kimberly A Babson, James Sottile, Danielle Morabito
PURPOSE OF REVIEW: The current review aims to summarize the state of research on cannabis and sleep up to 2014 and to review in detail the literature on cannabis and specific sleep disorders from 2014 to the time of publication. RECENT FINDINGS: Preliminary research into cannabis and insomnia suggests that cannabidiol (CBD) may have therapeutic potential for the treatment of insomnia. Delta-9 tetrahydrocannabinol (THC) may decrease sleep latency but could impair sleep quality long-term...
April 2017: Current Psychiatry Reports
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