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Endothelial function diet

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https://www.readbyqxmd.com/read/28820443/omega-3-polyunsaturated-fatty-acids-improve-endothelial-dysfunction-in-chronic-renal-failure-role-of-enos-activation-and-of-oxidative-stress
#1
Michela Zanetti, Gianluca Gortan Cappellari, Davide Barbetta, Annamaria Semolic, Rocco Barazzoni
BACKGROUND: Endothelial dysfunction is a key vascular alteration in chronic kidney disease (CKD). Omega 3 (n-3) polyunsaturated fatty acids (PUFA) reduce vascular oxidative stress and inflammation. We investigated whether n-3 PUFA could reverse endothelial dysfunction in CKD by improving endothelial nitric oxide synthase (eNOS) function and oxidative stress. METHODS: 5/6 nephrectomized male Wistar rats (CKD; n = 10) and sham operated animals (SHAM; n = 10) were treated for 6 weeks with standard diet...
August 18, 2017: Nutrients
https://www.readbyqxmd.com/read/28804559/microrna-1907-enhances-atherosclerosis-associated-endothelial-cell-apoptosis-by-suppressing-bcl-2
#2
Jin Zhao, Shu-Lin Ou, Wei-You Wang, Chang Yan, Lu-Xiang Chi
Injury and endothelial cell apoptosis are hall marks of atherosclerosis (AS). However, the mechanisms underlying its pathogenesis remain ill-defined. Recent evidence of a role for microRNAs in AS-associated endothelial cell apoptosis encouraged us to address this question. Here, AS was developed in ApoE (-/-) mice supplied with a high-fat diet (HFD), compared to ApoE (-/-) mice supplied with a normal diet (ND). Mouse endothelial cells were isolated from the aortic arch using flow cytometry based on their expression of CD31...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28802834/vegetable-derived-bioactive-nitrate-and-cardiovascular-health
#3
REVIEW
Catherine P Bondonno, Lauren C Blekkenhorst, Alex H Liu, Nicola P Bondonno, Natalie C Ward, Kevin D Croft, Jonathan M Hodgson
Vegetable derived nitrate is now recognised as an important bioactive phytochemical with cardioprotective properties. Nitrate, through the recently described enterosalivary nitrate-nitrite-nitric oxide (NO) pathway, increases NO, a molecule pivotal for cardiovascular health. Clinical trials have observed that dietary nitrate has similar effects to NO when supplied exogenously. These effects include reduced blood pressure and improvements in other markers of vascular health such as endothelial function, arterial stiffness, ischemia reperfusion injury, blood flow, and platelet aggregation...
August 9, 2017: Molecular Aspects of Medicine
https://www.readbyqxmd.com/read/28802571/omega-3-polyunsaturated-fatty-acids-improve-endothelial-function-in-humans-at-risk-for-atherosclerosis-a-review
#4
REVIEW
Kayla R Zehr, Mary K Walker
Epidemiology studies and clinical trials show that omega-3 polyunsaturated fatty acids (n-3 PUFAs) can prevent atherosclerotic morbidity and evidence suggests this may be mediated by improving endothelial dysfunction. Endothelial dysfunction is characterized by reduced vasodilation and a pro-inflammatory, pro-thrombotic state, and is an early pathological event in the development of atherosclerosis. Flow-mediated dilation (FMD), a gold standard for assessing endothelial dysfunction, is a predictor of future cardiovascular events and coronary heart disease risk...
August 9, 2017: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/28782150/mri-assessment-of-coronary-microvascular-endothelial-nitric-oxide-synthase-function-using-myocardial-t1-mapping
#5
Sophia X Cui, Frederick H Epstein
PURPOSE: Endothelial nitric oxide synthase (eNOS) plays a central role in regulating vascular tone, blood flow, and microvascular permeability. Endothelial dysfunction, including eNOS dysfunction, is an early biomarker of vascular disease. This study aimed to show that myocardial T1 mapping during nitric oxide synthase (NOS) inhibition could assess coronary microvascular eNOS function. METHODS: Wild-type mice, eNOS(-/-) mice, and wild-type mice fed a high-fat diet underwent T1 mapping at baseline and for 20 min after injection of N(G) -nitro-L-arginine methyl ester (LNAME), a NOS inhibitor...
August 7, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28781215/adipose-derived-stem-cell-derived-exosomes-ameliorate-erectile-dysfunction-in-a-rat-model-of-type-2-diabetes
#6
Fengzhi Chen, Haibo Zhang, Zhiqiang Wang, Wei Ding, Qinyu Zeng, Wenbing Liu, Can Huang, Shuhua He, Anyang Wei
BACKGROUND: The efficacy of adipose-derived stem cells (ADSCs) in alleviating erectile dysfunction (ED) of diabetic rats has been demonstrated mainly through a paracrine effect. However, exosomes (EXOs), which are important bioactive substance vectors secreted by ADSCs, have never been associated with ED. AIM: To investigate the effect of ADSC-derived EXOs on erectile function in a type 2 diabetic ED rat model. METHODS: EXOs were isolated from the supernatants of cultured ADSCs by ultracentrifugation...
August 3, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28760336/dietary-magnesium-supplementation-prevents-and-reverses-vascular-and-soft-tissue-calcifications-in-uremic-rats
#7
Juan M Diaz-Tocados, Alan Peralta-Ramirez, María E Rodríguez-Ortiz, Ana I Raya, Ignacio Lopez, Carmen Pineda, Carmen Herencia, Addy Montes de Oca, Noemi Vergara, Sonja Steppan, M Victoria Pendon-Ruiz de Mier, Paula Buendía, Andrés Carmona, Julia Carracedo, Juan F Alcalá-Díaz, Joao Frazao, Julio M Martínez-Moreno, Antonio Canalejo, Arnold Felsenfeld, Mariano Rodriguez, Escolástico Aguilera-Tejero, Yolanda Almadén, Juan R Muñoz-Castañeda
Although magnesium has been shown to prevent vascular calcification in vitro, controlled in vivo studies in uremic animal models are limited. To determine whether dietary magnesium supplementation protects against the development of vascular calcification, 5/6 nephrectomized Wistar rats were fed diets with different magnesium content increasing from 0.1 to 1.1%. In one study we analyzed bone specimens from rats fed 0.1%, 0.3%, and 0.6% magnesium diets, and in another study we evaluated the effect of intraperitoneal magnesium on vascular calcification in 5/6 nephrectomized rats...
July 28, 2017: Kidney International
https://www.readbyqxmd.com/read/28759085/resveratrol-did-not-alter-blood-pressure-in-rats-with-nitric-oxide-synthase-inhibited-hypertension
#8
Mehmet Aydin, Buket Gungor, A Secil Akdur, Hakki Engin Aksulu, Coskun Silan, Ibrahim Susam, Ali Kemal Cabuk, Gizem Cabuk
BACKGROUND: Inhibition of nitric oxide synthase (NOS) is a well-known experimental model of hypertension (HT). It was shown that oxidative stress contributes to the pathogenesis of HT. Resveratrol is a potent anti-oxidant that is found in red grapes, peanuts and red wine. It improves the NO response and increases endothelial NOS expression, which causes endothelium-dependent vasorelaxation as well as renal vasodilation. We aimed to explore the effects of resveratrol on blood pressure, the water-salt balance and sodium excretion as a reflection of renal function in NOS-inhibited rat models...
May 2017: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/28751928/a-decrease-of-brain-microrna-122-level-is-an-early-marker-of-cerebrovascular-disease-in-the-stroke-prone-spontaneously-hypertensive-rat
#9
Rosita Stanzione, Franca Bianchi, Maria Cotugno, Simona Marchitti, Maurizio Forte, Carla Busceti, Larisa Ryskalin, Francesco Fornai, Massimo Volpe, Speranza Rubattu
Based on preliminary evidence that highlights microRNA-122 as a contributing factor to stroke pathogenesis, we aimed at assessing its expression level, along with the presence of early signs of cerebrovascular disease, in the brain of stroke-prone spontaneously hypertensive rat (SHRSP), a suitable model of human disease that accelerates stroke occurrence under a high sodium/low potassium (Japanese-style) diet (JD). After one month of JD, before stroke occurrence, brain microRNA-122 level was significantly decreased in SHRSP as compared to the stroke-resistant SHR (SHRSR)...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28731131/assessment-of-the-antioxidant-activity-of-an-olive-oil-total-polyphenolic-fraction-and-hydroxytyrosol-from-a-greek-olea%C3%A2-europea-variety-in-endothelial-cells-and-myoblasts
#10
Paraskevi Kouka, Alexandros Priftis, Dimitrios Stagos, Apostolis Angelis, Panagiotis Stathopoulos, Nikos Xinos, Alexios-Léandros Skaltsounis, Charalampos Mamoulakis, Aristides M Tsatsakis, Demetrios A Spandidos, Demetrios Kouretas
Olive oil (OO) constitutes the basis of the Mediterranean diet, and it seems that its biophenols, such as hydroxytyrosol (HT) may scavenge free radicals, attracting distinct attention due to their beneficial effects in many pathological conditions, such as cancer. To the best of our knowedge, this is the first study in which the functional properties of an OO total polyphenolic fraction (TPF) and pure HT were examined in order to determine their antioxidant effects at a cellular level in endothelial cells and myoblasts...
September 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28723693/upregulation-of-microrna-876-induces-endothelial-cell-apoptosis-by-suppressing-bcl-xl-in-development-of-atherosclerosis
#11
Kaicheng Xu, Peng Liu, Yue Zhao
BACKGROUND/AIMS: The injury and apoptotic cell death of endothelial cells hallmark the development of atherosclerosis (AS), characterized by dysregulation of lipid homeostasis, immune responses, and formation of coronary plaques. However, the mechanisms underlying the initiation of endothelial cell apoptosis remain ill-defined. Recent evidence suggests a role of microRNAs in the processes of AS-associated endothelial cell apoptosis. Thus, we studied this question in the current study...
July 19, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28721161/repeated-positive-acceleration-exposure-exacerbates-endothelial-dysfunction-in-high-fat-diet-induced-hyperlipidemic-rats
#12
Zhihui Yang, Hua Ge, Chunya Wang, Zhongdong Li, Qingjun Zhang, Jianchang Wang
INTRODUCTION: It remains unclear whether exposure to repeated positive acceleration (+Gz) can exacerbate endothelial dysfunction on the basis of hyperlipidemia. The aim of this study was to investigate the effect of repeated +Gz exposure on endothelial function in high-fat-diet-induced hyperlipidemic rats. MATERIAL AND METHODS: Male Sprague-Dawley rats were randomly divided into control, repeat +Gz exposure, high-fat diet (HFD), and +Gz + HFD groups. The rats in the +Gz group were exposed to +Gz and the rats in the HFD group were fed a diet with 2% cholesterol...
June 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28721160/genetic-disruption-of-multidrug-resistance-associated-protein-1-improves-endothelial-function-and-attenuates-atherosclerosis-in-mrp1-ldlr-double-knockout-mice
#13
Julian Jehle, Cornelius F H Müller, Adem Aksoy, Sebastian Zimmer, Georg Nickenig, Vedat Tiyerili
INTRODUCTION: Multidrug resistance-associated protein 1 (MRP1) is an anion transporter which is implicated in the efflux of the intracellular antioxidant anion glutathione as well as leukotrienes. Pharmacological inhibition of MRP1 exhibits antioxidative and anti-atherosclerotic effects both in vitro and in vivo. However, pharmacological inhibitors of MRP1 lack selectivity, which prompted us to study the in vivo impact of a genetic disruption of MRP1 on endothelial dysfunction, reactive oxygen species formation and atherogenesis in an atherosclerotic mouse model...
June 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28713487/moringa-oleifera-seeds-attenuate-vascular-oxidative-and-nitrosative-stresses-in-spontaneously-hypertensive-rats
#14
Joseph Iharinjaka Randriamboavonjy, Marc Rio, Pierre Pacaud, Gervaise Loirand, Angela Tesse
Moringa oleifera (MOI) is a tree currently used in traditional medicine in tropical Africa, America, and Asia for therapeutic applications in several disorders including arterial hypertension. We previously described a cardiac protective role of a treatment with MOI seeds in spontaneously hypertensive rats (SHR). Here, we investigated the effects of this treatment on oxidative and nitrosative vascular stresses in SHR, with normotensive Wistar Kyoto rats used as controls. Oxidative and nitrosative stresses detected in SHR aortas using the fluorescent dye dihydroethidine and protein nitrotyrosine staining were reduced in MOI-treated SHR aortas...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28713285/amiloride-improves-endothelial-function-and-reduces-vascular-stiffness-in-female-mice-fed-a-western-diet
#15
Luis A Martinez-Lemus, Annayya R Aroor, Francisco I Ramirez-Perez, Guanghong Jia, Javad Habibi, Vincent G DeMarco, Brady Barron, Adam Whaley-Connell, Ravi Nistala, James R Sowers
Obese premenopausal women lose their sex related cardiovascular disease protection and develop greater arterial stiffening than age matched men. In female mice, we have shown that consumption of a Western diet (WD), high in fat and refined sugars, is associated with endothelial dysfunction and vascular stiffening, which occur via activation of mineralocorticoid receptors and associated increases in epithelial Na(+) channel (ENaC) activity on endothelial cells (EnNaC). Herein our aim was to determine the effect that reducing EnNaC activity with a very-low-dose of amiloride would have on decreasing endothelial and arterial stiffness in young female mice consuming a WD...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28710554/morphofunctional-changes-after-sleeve-gastrectomy-and-very-low-calorie-diet-in-an-animal-model-of-non-alcoholic-fatty-liver-disease
#16
Eider Talavera-Urquijo, Sarai Rodríguez-Navarro, Marc Beisani, Maria Teresa Salcedo-Allende, Aisha Chakkur, Marc Arús-Avilés, Manel Cremades, Salvador Augustin, María Martell, José M Balibrea
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease and is found in 70% of obese people. The evidence available to date suggests that bariatric surgery could be an effective treatment by reducing weight and also by improving metabolic complications in the long term. This work aimed to compare, in a diet-induced NAFLD animal model, the effect of both sleeve gastrectomy (SG) and very-low calorie diet (VLCD). METHODS: Thirty-five Wistar rats were divided into control rats (n = 7) and obese rats fed a high-fat diet (HFD)...
July 15, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28709892/liuwei-dihuang-soft-capsules-attenuates-endothelial-cell-apoptosis-to-prevent-atherosclerosis-through-gpr30-mediated-regulation-in-ovariectomized-apoe-deficient-mice
#17
Yi Jing, Danfeng Cai, Qi Chen, Qingping Xiong, Tianhui Hu, Yuan Yao, Chao Lin, Xin Sun, Ying Lu, Xueyun Kong, Xiang Wu, Yu Li, Huimin Bian
ETHNOPHARMACOLOGICAL RELEVANCE: Liuwei Dihuang (LWDH), a classical traditional Chinese medicine prescription, has been widely used to prevent and to treat various diseases with symptoms of 'Kidney-Yin' deficiency syndrome for over 1000 years in China. It is commonly used to treat functional decline associated with senile disease and menopausal syndrome, especially memory decline, insomnia, diabetes and osteoporosis. Modern experimental pharmacological studies indicated that the mechanism of LWDH treatment of menopausal syndrome may be associated with enhanced estrogenic effects...
July 12, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28707593/effects-of-some-indigenous-plants-of-north-karnataka-india-on-cardiovascular-and-glucose-regulatory-systems-in-diabetic-rats
#18
Kusal K Das, Kailash S Chadchan, R Chandramouli Reddy, M S Biradar, Pallavi S Kanthe, Bheemshetty S Pati, Jeevan G Ambekar, Ishwar B Bagoji, Swastika Das
BACKGROUND: The medicinal plants of north Karnataka, India are always researchers delight as many of these plants are rarely found in elsewhere other than this part of India. Kenaf leaves (Hibiscus cannabinus Linn, Pundi), Chick pea leaves (Cicer arietinum Linn, Chana) and Prickly lettuce leaves (Lactuca scariola Linn, Hattaraki.) are a few of these indigenous plants which are routinely consumed by the people as diet in this part of India. Various studies were done on these plants to find out some potential anti diabetic efficacies but reports are still not encouraging...
July 12, 2017: Cardiovascular & Hematological Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28701241/arginine-metabolism-and-its-protective-effects-on-intestinal-health-and-functions-in-weaned-piglets-under-oxidative-stress-induced-by-diquat
#19
Ping Zheng, Bing Yu, Jun He, Jie Yu, Xiangbing Mao, Yuheng Luo, Junqiu Luo, Zhiqing Huang, Gang Tian, Qiufeng Zeng, Lianqiang Che, Daiwen Chen
The intestine plays key roles in maintaining body arginine (Arg) homoeostasis. Meanwhile, the intestine is very susceptible to reactive oxygen species. In light of this, the study aimed to explore the effects of Arg supplementation on intestinal morphology, Arg transporters and metabolism, and the potential protective mechanism of Arg supplementation in piglets under oxidative stress. A total of thirty-six weaned piglets were randomly allocated to six groups with six replicates and fed a base diet (0·95 % Arg,) or base diet supplemented with 0·8 % and 1·6 % l-Arg for 1 week, respectively...
June 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28689502/intrauterine-growth-restriction-induced-deleterious-adaptations-in-endothelial-progenitor-cells-possible-mechanism-to-impair-endothelial-function
#20
V Oliveira, L V de Souza, T Fernandes, S D S Junior, M H C de Carvalho, E H Akamine, L C Michelini, E M de Oliveira, M D C Franco
Intrauterine growth restriction (IUGR) can induce deleterious changes in the modulatory ability of the vascular endothelium, contributing to an increased risk of developing cardiovascular diseases in the long term. However, the mechanisms involved are not fully understood. Emerging evidence has suggested the potential role of endothelial progenitor cells (EPCs) in vascular health and repair. Therefore, we aimed to evaluate the effects of IUGR on vascular reactivity and EPCs derived from the peripheral blood (PB) and bone marrow (BM) in vitro...
July 10, 2017: Journal of Developmental Origins of Health and Disease
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