keyword
MENU ▼
Read by QxMD icon Read
search

Endothelial function diet

keyword
https://www.readbyqxmd.com/read/29667441/long-term-consumption-of-western-diet-contributes-to-endothelial-dysfunction-and-aortic-remodeling-in-rats-implication-of-rho-kinase-signaling
#1
Rania A Elrashidy, Jing Zhang, Guiming Liu
Western diet (WD), rich in saturated fat and sugars, has become a risk factor for obesity and metabolic syndrome, however, its effect on endothelial function and vascular remodeling is not fully elucidated. Recent evidence suggests cross-talk between Rho kinase (ROCK) pathway and cardiovascular system. We aimed to investigate the effect of WD on aortic remodeling and the contribution of ROCK signaling. Eight week old male Sprague-Dawley rats were fed either standard chow diet (SD) or high fructose/ high-fat diet, typically as in WD...
April 18, 2018: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29659685/can-curcumin-counteract-cognitive-decline-clinical-trial-evidence-and-rationale-for-combining-%C3%AF-3-fatty-acids-with-curcumin
#2
Julia Christina Kuszewski, Rachel Heloise Xiwen Wong, Peter Ranald Charles Howe
The rate of cognitive decline in the elderly is highly variable. One potential factor contributing to accelerated cognitive decline is chronic systemic inflammation, because it has been linked to cognitive impairment and increased dementia risk. Certain lifestyle factors, such as excess body weight and sedentary behavior, can exacerbate a proinflammatory state in older adults, resulting in chronic low-grade inflammation. Supplementing the diet with curcumin, an anti-inflammatory polyphenolic compound from the curry spice turmeric, is a potential approach to prevent accelerated cognitive decline by counteracting chronic inflammatory processes...
March 1, 2018: Advances in Nutrition
https://www.readbyqxmd.com/read/29652545/strategies-for-optimal-cardiovascular-aging
#3
Douglas R Seals, Vienna E Brunt, Matthew J Rossman
This review summarizes the opening keynote presentation overview of the American Physiological Society conference on Cardiovascular Aging: New Frontiers and Old Friends held in Westminster, CO, in August 2017. Age is the primary risk factor for cardiovascular diseases (CVD). Without effective intervention, increased numbers of older adults in the future will translate to greater prevalence of CVD and related disorders. Advancing age increases the risk of CVD partly via direct effects on the heart and through increases in blood pressure; however, much of the risk is mediated by arterial dysfunction, including large elastic artery stiffening and both macro- and micro-vascular endothelial dysfunction...
April 13, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29615924/protective-role-of-perivascular-adipose-tissue-in-endothelial-dysfunction-and-insulin-induced-vasodilatation-of-hypercholesterolemic-ldl-receptor-deficient-mice
#4
Natali Baltieri, Daniele M Guizoni, Jamaira A Victorio, Ana P Davel
Background: Endothelial dysfunction plays a pivotal role in the initiation of atherosclerosis. Vascular insulin resistance might contribute to a reduction in endothelial nitric oxide (NO) production, leading to impaired endothelium-dependent relaxation in cardiometabolic diseases. Because perivascular adipose tissue (PVAT) controls endothelial function and NO bioavailability, we hypothesized a role for this fat deposit in the vascular complications associated with the initial stages of atherosclerosis. Therefore, we investigated the potential involvement of PVAT in the early endothelial dysfunction in hypercholesterolemic LDL receptor knockout mice (LDLr-KO)...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29595858/calycosin-directly-improves-perivascular-adipose-tissue-dysfunction-by-upregulating-the-adiponectin-ampk-enos-pathway-in-obese-mice
#5
Fang Han, Kai Li, Ruiyan Pan, Wenjie Xu, Xue Han, Ningning Hou, Xiaodong Sun
Perivascular adipose tissue (PVAT) loses its anti-contractile activity in obesity. Calycosin, the major bioactive isoflavonoid, was shown to protect endothelial function. However, effects of calycosin on PVAT function in obesity remain unclear. We aimed to investigate the effects of calycosin on the anti-contractile activity of PVAT in obese mice and its potential mechanisms. Obesity in mice was induced with a high-fat diet, with or without calycosin treatment. Thoracic aorta responses to phenylephrine were determined...
March 29, 2018: Food & Function
https://www.readbyqxmd.com/read/29560080/hydrogen-sulfide-abrogates-hemoglobin-lipid-interaction-in-atherosclerotic-lesion
#6
László Potor, Péter Nagy, Gábor Méhes, Zoltán Hendrik, Viktória Jeney, Dávid Pethő, Anita Vasas, Zoltán Pálinkás, Enikő Balogh, Ágnes Gyetvai, Matthew Whiteman, Roberta Torregrossa, Mark E Wood, Sándor Olvasztó, Péter Nagy, György Balla, József Balla
The infiltration of red blood cells into atheromatous plaques is implicated in atherogenesis. Inside the lesion, hemoglobin (Hb) is oxidized to ferri- and ferrylHb which exhibit prooxidant and proinflammatory activities. Cystathione gamma-lyase- (CSE-) derived H2 S has been suggested to possess various antiatherogenic actions. Expression of CSE was upregulated predominantly in macrophages, foam cells, and myofibroblasts of human atherosclerotic lesions derived from carotid artery specimens of patients. A similar pattern was observed in aortic lesions of apolipoprotein E-deficient mice on high-fat diet...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29559876/dietary-glycine-is-rate-limiting-for-glutathione-synthesis-and-may-have-broad-potential-for-health-protection
#7
REVIEW
Mark F McCarty, James H O'Keefe, James J DiNicolantonio
Background: Glutathione is a key scavenging antioxidant that opposes the proinflammatory signaling of hydrogen peroxide. Boosting cellular glutathione levels may have broad utility in the prevention and treatment of disorders driven by oxidative stress. Supplemental N-acetylcysteine has been employed for this purpose. Could supplemental glycine likewise promote glutathione synthesis? Methods: We conducted a review of the pertinent literature using PubMed. Results: Tissue glycine levels are lower than the glutathione synthase Michaelis constant (Km ) for glycine...
2018: Ochsner Journal
https://www.readbyqxmd.com/read/29559522/aibp-protects-against-metabolic-abnormalities-and-atherosclerosis
#8
Dina A Schneider, Soo-Ho Choi, Colin Agatisa-Boyle, Laurence Zhu, Jungsu Kim, Jennifer Pattison, Dorothy D Sears, Philip L S M Gordts, Longhou Fang, Yury I Miller
Apolipoprotein A-I Binding Protein (AIBP) has been shown to augment cholesterol efflux from endothelial cells and macrophages. In zebrafish and mice, AIBP-mediated regulation of cholesterol levels in the plasma membrane of endothelial cells controls angiogenesis. The goal of this work was to evaluate metabolic changes and atherosclerosis in AIBP loss-of-function and gain-of-function animal studies. Here we show that Apoa1bp-/-Ldlr-/- mice fed a high-cholesterol, high-fat diet had exacerbated weight gain, liver steatosis, glucose intolerance, hypercholesterolemia and hypertriglyceridemia, and larger atherosclerotic lesions compared to Ldlr-/- mice...
March 20, 2018: Journal of Lipid Research
https://www.readbyqxmd.com/read/29552825/-antihypertensive-effect-and-mechanism-of-dendrobium-officinale-flos-on-high-blood-pressure-rats-induced-by-high-glucose-and-high-fat-compound-alcohol
#9
Kai-Lun Liang, Ping Fang, Qiu-Qiu Shi, Jie Su, Bo Li, Su-Hong Chen, Gui-Yuan Lv
This study aimed to investigate the antihypertensive effect and possible mechanism of Dendrobium officinale flos on hypertensive rats induced by high glucose and high fat compound alcohol. The hypertensive models were successfully made by high-glucose and high-fat diet, with gradient drinking for 4 weeks, and then divided into model control group, valsartan (5.7 mg·kg⁻¹) positive control group and D. officinale flos groups (3,1 g·kg⁻¹). After 6 weeks of treatment, the blood pressure of rats was measured regularly...
January 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29548794/potential-mechanisms-underlying-cardiovascular-protection-by-polyphenols-role-of-the-endothelium
#10
Min-Ho Oak, Cyril Auger, Eugenia Belcastro, Sin-Hee Park, Hyun-Ho Lee, Valérie B Schini-Kerth
Epidemiological studies have indicated that regular intake of polyphenol-rich diets such as red wine and tea, are associated with a reduced risk of cardiovascular diseases. The beneficial effect of polyphenol-rich products has been attributable, at least in part, to their direct action on the endothelial function. Indeed, polyphenols from tea, grapes, cacao, berries, and plants have been shown to activate endothelial cells to increase the formation of potent vasoprotective factors including nitric oxide (NO) and to delay endothelial ageing...
March 13, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29544657/functional-foods-for-augmenting-nitric-oxide-activity-and-reducing-the-risk-for-salt-induced-hypertension-and-cardiovascular-disease-in-japan
#11
REVIEW
Theodore W Kurtz, Stephen E DiCarlo, Michal Pravenec, R Curtis Morris
High salt intake is one of the major dietary determinants of hypertension and cardiovascular disease in Japan and throughout the world. Although dietary salt restriction may be of clinical benefit in salt-sensitive individuals, many individuals may not wish, or be able to, reduce their intake of salt. Thus, identification of functional foods that can help protect against mechanistic abnormalities mediating salt-induced hypertension is an issue of considerable medical and scientific interest. According to the "vasodysfunction" theory of salt-induced hypertension, the hemodynamic abnormality initiating salt-induced increases in blood pressure usually involves subnormal vasodilation and abnormally increased vascular resistance in response to increased salt intake...
March 12, 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29527166/icariin-ameliorate-thiram-induced-tibial-dyschondroplasia-via-regulation-of-wnt4-and-vegf-expression-in-broiler-chickens
#12
Hui Zhang, Khalid Mehmood, Kun Li, Mujeeb U Rehman, Xiong Jiang, Shucheng Huang, Lei Wang, Lihong Zhang, Xiaole Tong, Fazul Nabi, Wangyuan Yao, Muhammad K Iqbal, Muhammad Shahzad, Jiakui Li
Tibial dyschondroplasia (TD) is main bone problem in fast growing poultry birds that effect proximal growth plate (GP) of tibia bone. TD is broadly defined as non-vascularized and non-mineralized, and enlarged GP with tibia bone deformation and lameness. Icariin ( Epimedium sagittatum ) is a traditional Chinese medicine, which is commonly practiced in the treatment of various bone diseases. Recently, many researcher reports about the beneficial effects of icariin in relation to various types of bone conditions but no report is available about promoting effect of icariin against TD...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29525532/developmental-programming-of-vascular-dysfunction-by-prenatal-and-postnatal-zinc-deficiency-in-male-and-female-rats
#13
Facundo Mendes Garrido Abregú, María Natalia Gobetto, Lorena Vanesa Juriol, Carolina Caniffi, Rosana Elesgaray, Analía Lorena Tomat, Cristina Arranz
Micronutrient malnutrition during intrauterine and postnatal growth may program cardiovascular diseases in adulthood. We examined whether moderate zinc restriction in male and female rats throughout fetal life, lactation and/or postweaning growth induces alterations that can predispose to the onset of vascular dysfunction in adulthood. Female Wistar rats were fed low- or control zinc diets from pregnancy to offspring weaning. After weaning, offspring were fed either a low- or a control zinc diet until 81 days...
February 9, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29512459/quercetin-a-plant-derived-polyphenol-with-tremendous-cardioprotective-effects
#14
Rahul V Patel, Bhupendra M Mistry, Riyaz Syed, Anuj K Rathi, Young-Soo Keum
Flavonoids are allocated among various vegetations and in foodstuffs; consequently, they represent an inevitable part of the diet. Historical and epidemiological proof recommend that diet plans loaded with flavonoids such as quercetin have positive health benefits, especially on the heart. Flavonoids have been proven to have potential action towards hypertension, inflammation, diabetes and vascular disease. Their results on LDL lowering, platelet aggregation and vasodilatation recommend an ability to expel the pathophysiology of atherosclerotic plaque formation...
March 5, 2018: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/29511415/an-improvement-of-cardiovascular-risk-factors-by-omega-3-polyunsaturated-fatty-acids
#15
REVIEW
Hidekatsu Yanai, Yoshinori Masui, Hisayuki Katsuyama, Hiroki Adachi, Akiko Kawaguchi, Mariko Hakoshima, Yoko Waragai, Tadanao Harigae, Akahito Sako
An epidemiological survey in the Northwest Greenland reported that the Greenlanders have a lower frequency of acute myocardial infarction and diabetes mellitus. The very low incidence of ischemic heart disease in the Greenlanders was explained by consumption of a diet rich in omega-3 polyunsaturated fatty acids (PUFAs). Possible anti-atherothrombotic effects of omega-3 PUFA include an improvement of lipid metabolism such as a reduction of triglyceride and an increase of high-density lipoprotein-cholesterol (HDL-C), and glucose metabolism, anti-platelet activity, anti-inflammatory effects, an improvement of endothelial function and stabilization of atherosclerotic plaque...
April 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29507690/chronic-hyperuricemia-impairs-blood-flow-recovery-in-the-ischemic-hindlimb-through-suppression-of-endothelial-progenitor-cells
#16
I-Chun Chen, Chin-Sung Kuo, Chih-Cheng Wu, Hsiao-Ya Tsai, Chih-Pei Lin, Szu-Yuan Li, Ruey-Hsing Chou, Po-Hsun Huang, Jaw-Wen Chen, Shing-Jong Lin
Objective: Chronic hyperuricemia is associated with cardiovascular disease, but its impact on endothelial progenitor cells (EPC) and ischemia-induced neovascularization remains unclear. Herein we investigated whether chronic hyperuricemia could impede blood flow recovery in response to tissue ischemia by suppression of EPC. Methods: Human EPC were isolated and cultured in a high-level uric acid medium for functional testing. Cell proliferation, nitric oxide (NO) production and apoptosis assay were examined...
February 6, 2018: Oncotarget
https://www.readbyqxmd.com/read/29502106/hypercholesterolemia-induced-loss-of-flow-induced-vasodilation-and-lesion-formation-in-apolipoprotein-e-deficient-mice-critically-depend-on-inwardly-rectifying-k-channels
#17
Ibra S Fancher, Sang Joon Ahn, Crystal Adamos, Catherine Osborn, Myung-Jin Oh, Yun Fang, Catherine A Reardon, Godfrey S Getz, Shane A Phillips, Irena Levitan
BACKGROUND: Hypercholesterolemia-induced decreased availability of nitric oxide (NO) is a major factor in cardiovascular disease. We previously established that cholesterol suppresses endothelial inwardly rectifying K+ (Kir) channels and that Kir2.1 is an upstream mediator of flow-induced NO production. Therefore, we tested the hypothesis that suppression of Kir2.1 is responsible for hypercholesterolemia-induced inhibition of flow-induced NO production and flow-induced vasodilation (FIV)...
March 3, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29493813/rapid-adipose-tissue-expansion-triggers-unique-proliferation-and-lipid-accumulation-profiles-in-adipose-tissue-macrophages
#18
Lindsey A Muir, Samadhi Kiridena, Cameron Griffin, Jennifer B DelProposto, Lynn Geletka, Gabriel Martinez-Santibañez, Brian F Zamarron, Hannah Lucas, Kanakadurga Singer, Robert W O' Rourke, Carey N Lumeng
Obesity-related changes in adipose tissue leukocytes, in particular adipose tissue macrophages (ATMs) and dendritic cells (ATDCs), are implicated in metabolic inflammation, insulin resistance, and altered regulation of adipocyte function. We evaluated stromal cell and white adipose tissue (WAT) expansion dynamics with high fat diet (HFD) feeding for 3-56 days, quantifying ATMs, ATDCs, endothelial cells (ECs), and preadipocytes (PAs) in visceral epididymal WAT and subcutaneous inguinal WAT. To better understand mechanisms of the early response to obesity, we evaluated ATM proliferation and lipid accumulation...
March 1, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29488619/atra-improves-endothelial-dysfunction-in-atherosclerotic-rabbits-by-decreasing-cav%C3%A2-1-expression-and-enhancing-enos-activity
#19
Yan Wu, Xiaobian Wang, Qing Zhou, Yi Wang, Jiali Zhou, Qiaoling Jiang, Yuan Wang, Huaqing Zhu
The aim of the present study was to explore the protective effects and possible mechanisms of all‑trans‑retinoic acid (ATRA) against atherosclerosis (AS). Rabbits were randomly allocated for standard or high‑fat diet with or without ATRA. After 12 weeks, the aortic rings of the rabbits were removed. Endothelium‑dependent relaxation (EDR) induced by acetylcholine and non‑endothelium‑dependent relaxation induced by sodium nitroprusside in the thoracic aorta were evaluated. NO level and eNOS activity were measured according to the protocol of NO and eNOS ELISA kits...
February 27, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29475132/differential-effects-of-short-chain-fatty-acids-on-endothelial-nlrp3-inflammasome-activation-and-neointima-formation-antioxidant-action-of-butyrate
#20
Xinxu Yuan, Lei Wang, Owais M Bhat, Hannah Lohner, Pin-Lan Li
Short chain fatty acids (SCFAs), a family of gut microbial metabolites, have been reported to promote preservation of endothelial function and thereby exert anti-atherosclerotic action. However, the precise mechanism mediating this protective action of SCFAs remains unknown. The present study investigated the effects of SCFAs (acetate, propionate and butyrate) on the activation of Nod-like receptor pyrin domain 3 (Nlrp3) inflammasome in endothelial cells (ECs) and associated carotid neointima formation. Using a partial ligated carotid artery (PLCA) mouse model fed with the Western diet (WD), we found that butyrate significantly decreased Nlrp3 inflammasome formation and activation in the carotid arterial wall of wild type mice (Asc+/+ ), which was comparable to the effect of gene deletion of the adaptor protein apoptosis-associated speck-like protein gene (Asc-/- )...
February 13, 2018: Redox Biology
keyword
keyword
117733
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"