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https://www.readbyqxmd.com/read/29772973/evaluation-of-metronomic-cyclophosphamide-chemotherapy-as-maintenance-treatment-for-dogs-with-appendicular-osteosarcoma-following-limb-amputation-and-carboplatin-chemotherapy
#1
Arata Matsuyama, Courtney R Schott, Geoffrey A Wood, Danielle Richardson, J Paul Woods, Anthony J Mutsaers
OBJECTIVE To determine the effectiveness of metronomic cyclophosphamide (MC) chemotherapy (primary treatment of interest) with adjuvant meloxicam administration as maintenance treatment for dogs with appendicular osteosarcoma following limb amputation and carboplatin chemotherapy. DESIGN Retrospective case series with nested cohort study. ANIMALS 39 dogs with a histologic diagnosis of appendicular osteosarcoma that underwent limb amputation and completed carboplatin chemotherapy from January 2011 through December 2015...
June 1, 2018: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29730195/transient-myocardial-thickening-in-a-bartonella-henselae-positive-cat
#2
J L Joseph, E M Oxford, R A Santilli
A 3-year-old castrated male domestic shorthair presented to the Cornell University Hospital for Animals for acute onset respiratory distress. Thoracic radiographs, echocardiogram, and electrocardiogram (ECG) revealed left-sided congestive heart failure, myocardial thickening with left atrial dilation, and sinus rhythm conducted with a left bundle branch block, respectively. Cardiac troponin I was elevated and continued to increase over 36 h (1.9 ng/mL, 3.1 ng/mL, and 3.5 ng/mL, sequentially every 12 h)...
May 2, 2018: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
https://www.readbyqxmd.com/read/29694931/urinary-potassium-excretion-and-its-association-with-acute-kidney-injury-in-the-intensive-care-unit
#3
Alasdair R Burns, Kwok M Ho
PURPOSE: Using urinary indices as a quick bedside test to assist management of oliguria and acute kidney injury (AKI) has long been sought. This study assessed whether urinary potassium excretion is related to simultaneously calculated creatinine clearance (CrCl) and can predict AKI in the critically ill. MATERIALS AND METHODS: In this prospective cohort study, the correlation between 2-h urinary potassium excretion and simultaneously calculated CrCl of 61 critically ill patients was assessed by Pearson's correlation coefficient, and their ability to predict AKI (≥stage 1 KDIGO) in the subsequent 7 days was assessed by area under the receiver-operating-characteristic (AUROC) curve...
April 16, 2018: Journal of Critical Care
https://www.readbyqxmd.com/read/29673370/early-versus-standard-initiation-of-renal-replacement-therapy-in-furosemide-stress-test-non-responsive-acute-kidney-injury-patients-the-fst-trial
#4
Nuttha Lumlertgul, Sadudee Peerapornratana, Thananda Trakarnvanich, Wanjak Pongsittisak, Kajbundit Surasit, Anan Chuasuwan, Pleumjit Tankee, Khajohn Tiranathanagul, Kearkiat Praditpornsilpa, Kriang Tungsanga, Somchai Eiam-Ong, John A Kellum, Nattachai Srisawat
BACKGROUND: The timing of initiation of renal replacement therapy (RRT) in severe acute kidney injury (AKI) remains controversial, with early initiation resulting in unnecessary therapy for some patients while expectant therapy may delay RRT for other patients. The furosemide stress test (FST) has been shown to predict the need for RRT and therefore could be used to exclude low-risk patients from enrollment in trials of RRT timing. We conducted this multicenter pilot study to determine whether FST could be used to screen patients at high risk for RRT and to determine the feasibility of incorporating FST into a trial of early initiation of RRT...
April 19, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29669139/diuretic-or-sodium-restricted-diet-for-obstructive-sleep-apnea-a-randomized-trial
#5
Cintia Zappe Fiori, Denis Martinez, Carolina Caruccio Montanari, Pedro Lopez, Rodrigo Camargo, Lauren Sezerá, Sandro Cadaval Gonçalves, Flavio Danni Fuchs
Study Objectives: Interventions that decrease leg fluid retention reduce obstructive sleep apnea (OSA) severity in nonrandomized experiments. We aimed to investigate in a randomized trial the effect of interventions that reduce fluid volume on OSA severity. Methods: Men diagnosed with severe OSA were randomized to receive daily spironolactone 100 mg + furosemide 20 mg or nutritional counseling to sodium-restricted diet plus placebo pill or placebo pill. All participants underwent home sleep apnea testing at baseline and after 1 week follow-up...
April 1, 2018: Sleep
https://www.readbyqxmd.com/read/29665130/optimization-of-a-drug-transporter-probe-cocktail-potential-screening-tool-for-transporter-mediated-drug-drug-interactions
#6
Peter Stopfer, Thomas Giessmann, Kathrin Hohl, Sabine Hutzel, Sven Schmidt, Dietmar Gansser, Naoki Ishiguro, Mitchell E Taub, Ashish Sharma, Thomas Ebner, Fabian Müller
AIMS: Previous pharmacokinetic characterization of a transporter probe cocktail containing digoxin (P-gp), furosemide (OAT1, OAT3), metformin (OCT2, MATE1, MATE2-K) and rosuvastatin (OATP1B1, OATP1B3, BCRP) in healthy subjects showed increases in rosuvastatin systemic exposure compared to rosuvastatin alone. In this trial, the doses of metformin and furosemide as putative perpetrators were reduced to eliminate their drug-drug interaction (DDI) with rosuvastatin. METHODS: In a randomized, open label, single center, five-treatment, five-period crossover trial, 30 healthy male subjects received as reference treatments separately 0...
April 17, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29662328/hyporeninemic-hypoaldosteronism-in-a-patient-with-diabetes-mellitus-an-unforgettable-case-report
#7
Naziha Chelaghma, Samson O Oyibo
A 58-year-old man presented with a 3-year history of chronic and intermittent hyperkalemia requiring recurrent attendances to the emergency department for urgent treatment. His medical history included secondary diabetes mellitus following a bout of acute pancreatitis and a previous splenectomy for a spontaneous splenic rupture. He also had a history of prolonged use of non-steroidal anti-inflammatory drugs for back pain and painful neuropathy. He was not on any medication or diet that would cause a raised serum potassium level and his renal function was normal...
2018: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/29558036/comparison-of-the-anticonvulsant-potency-of-various-diuretic-drugs-in-the-maximal-electroshock-induced-seizure-threshold-test-in-mice
#8
Katarzyna Załuska, Maria W Kondrat-Wróbel, Jarogniew J Łuszczki
BACKGROUND: The coexistence of seizures and arterial hypertension requires an adequate and efficacious treatment involving both protection from seizures and reduction of high arterial blood pressure. Accumulating evidence indicates that some diuretic drugs (with a well-established position in the treatment of arterial hypertension) also possess anticonvulsant properties in various experimental models of epilepsy. OBJECTIVES: The aim of this study was to assess the anticonvulsant potency of 6 commonly used diuretic drugs (i...
March 20, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29518821/cerebellar-%C3%AE-6-subunit-containing-gaba-a-receptors-a-novel-therapeutic-target-for-disrupted-prepulse-inhibition-in-neuropsychiatric-disorders
#9
Lih-Chu Chiou, Hsin-Jung Lee, Margot Ernst, Wei-Jan Huang, Jui-Feng Chou, Hon-Lie Chen, Akihiro Mouri, Liang-Chieh Chen, Marco Treven, Takayoshi Mamiya, Pi-Chuan Fan, Daniel E Knutson, Chris Witzigmann, James Cook, Werner Sieghart, Toshitaka Nabeshima
BACKGROUND AND PURPOSE: The pathophysiological role of α6 -subunit-containing GABAA receptors, which are mainly expressed in cerebellar granule cells, remains unclear. Recently, we demonstrated that hispidulin, a flavonoid isolated from a local herb that remitted a patient's intractable motor tics, attenuated methamphetamine-induced hyperlocomotion in mice as a positive allosteric modulator (PAM) of cerebellar α6 GABAA receptors. Here, using hispidulin and a selective α6 GABAA receptor PAM, the pyrazoloquinolinone Compound 6, we revealed an unprecedented role of cerebellar α6 GABAA receptors in disrupted prepulse inhibition of the startle response (PPI), which reflects sensorimotor gating deficits manifested in several neuropsychiatric disorders...
March 8, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29515463/pulmonary-circulation-transvascular-fluid-fluxes-do-not-change-during-general-anesthesia-in-dogs
#10
Olga Frlic, Alenka Seliškar, Aleksandra Domanjko Petrič, Rok Blagus, George Heigenhauser, Modest Vengust
General anesthesia (GA) can cause abnormal lung fluid redistribution. Pulmonary circulation transvascular fluid fluxes ( J VA ) are attributed to changes in hydrostatic forces and erythrocyte volume (EV) regulation. Despite the very low hydraulic conductance of pulmonary microvasculature it is possible that GA may affect hydrostatic forces through changes in pulmonary vascular resistance (PVR), and EV through alteration of erythrocyte transmembrane ion fluxes ( ion J VA ). Furosemide (Fur) was also used because of its potential to affect pulmonary hydrostatic forces and ion J VA ...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29483879/effect-of-inhaled-nebulized-furosemide-40-and-120-mg-on-breathlessness-during-exercise-in-the-presence-of-external-thoracic-restriction-in-healthy-men
#11
Marcus Waskiw-Ford, Anne Wu, Amar Mainra, Noah Marchand, Abdullatif Alhuzaim, Jean Bourbeau, Benjamin M Smith, Dennis Jensen
Inhalation of nebulized furosemide has been shown to alleviate breathlessness provoked experimentally in health and disease; however, it remains unclear whether the efficacy of nebulized furosemide on breathlessness is dose-dependent. We tested the hypothesis that inhaled nebulized furosemide would be associated with a dose-dependent relief of breathlessness during exercise testing in the setting of abnormal restrictive constraints on tidal volume (VT ) expansion. In a randomized, double-blind, crossover study, 24 healthy men aged 25...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29477939/successful-weaning-from-continuous-renal-replacement-therapy-associated-risk-factors
#12
Joan M Raurich, Juan A Llompart-Pou, Mariana A Novo, Cristina Talavera, Mireia Ferreruela, Ignacio Ayestarán
PURPOSE: To identify risk factors of successful continuous renal replacement therapy (CRRT) weaning and to evaluate the effect of furosemide in the recovery of urine output after CRRT stop. MATERIALS AND METHODS: Retrospective, observational study of critical patients treated with CRRT. Weaning tests (WT) were classified in two groups: successful (urine output was recovered and CRRT was not required again) and failed (CRRT was required again). A multiple logistic regression model was used to identify risk factors of successful CRRT WT...
June 2018: Journal of Critical Care
https://www.readbyqxmd.com/read/29454528/continuous-infusion-versus-intermittent-bolus-injection-of-furosemide-in-critically-ill-patients-a-systematic-review-and-meta-analysis
#13
REVIEW
Ka Ting Ng, Aslinah Velayit, Delton Kah Yeang Khoo, Amirah Mohd Ismail, Marzida Mansor
OBJECTIVE: Fluid overload is a common phenomenon seen in intensive care units (ICUs). However, there is no general consensus on whether continuous or bolus furosemide is safer or more effective in these hemodynamically unstable ICU patients. The aim of this meta-analysis was to examine the clinical outcomes of continuous versus bolus furosemide in a critically ill population in ICUs. DATA SOURCES: MEDLINE, EMBASE, PubMed, and the Cochrane Database of Systematic reviews were searched from their inception until June 2017...
January 10, 2018: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29412704/with-no-lysine-kinase-4-modulates-sodium-potassium-2-chloride-cotransporter-activity-in-vivo
#14
Andrew Scott Terker, Maria Castaneda-Bueno, Mohammed Zubaerul Ferdaus, Ryan J Cornelius, Kayla J Erspamer, Xiao-Tong Su, Lauren N Miller, James A McCormick, Wen-Hui Wang, Gerardo Gamba, Chao-Ling Yang, David H Ellison
With no lysine kinase 4 (WNK4) is essential to activate the thiazide-sensitive NaCl cotransporter (NCC) along the distal convoluted tubule, an effect central to the phenotype of familial hyperkalemic hypertension. Although effects on potassium and sodium channels along the connecting and collecting tubules have also been documented, WNK4 is typically believed to have little role in modulating sodium chloride reabsorption along the thick ascending limb of the loop of Henle. Yet wnk4-/- mice (knockout mice lacking WNK4) do not demonstrate the hypocalciuria typical of pure distal convoluted tubule dysfunction...
February 7, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29410227/spot-urine-sodium-as-triage-for-effective-diuretic-infusion-in-an-ambulatory-heart-failure-unit
#15
D Marshall Brinkley, Laura J Burpee, Sunit-Preet Chaudhry, Jennifer A Smallwood, JoAnn Lindenfeld, Neal K Lakdawala, Akshay S Desai, Lynne W Stevenson
BACKGROUND: Admission for diuresis remains a common and costly event in patients with advanced heart failure (HF). We tested whether spot urine sodium could identify patients likely to respond to ambulatory diuretic infusion without hospitalization. METHODS AND RESULTS: We prospectively followed 176 consecutive patients with advanced heart failure receiving intravenous furosemide for congestion in an ambulatory clinic. Spot urine sodium was measured in 1st voided urine after diuretic infusion and compared with 3-hour urine output and subsequent risk of 30-day hospitalization or emergency department (ED) visit...
February 2, 2018: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/29403358/novel-peptide-vaccine-gv1001-rescues-hearing-in-kanamycin-furosemide-treated-mice
#16
Shin Hye Kim, Gaon Jung, Sangjae Kim, Ja-Won Koo
The cell-penetrating peptide GV1001 has been investigated as an anticancer agent and recently demonstrated anti-oxidant and anti-inflammatory effects. It has shown a protective effect on a kanamycin (KM)-induced ototoxicity mouse model. In the present study, we administered GV1001 at different time points after inducing hair cell damage, and examined if it rescues hair cell loss and restores hearing. A deaf mouse model was created by intraperitoneal injection of KM and furosemide. First, to test the early temporal change of hearing and extent of hair cell damage after KM and furosemide injection, hearing and outer hair cells (OHCs) morphology were evaluated on day 1, day 2 and day 3 after injection...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29368879/99mtc-dtpa-diuretic-renography-with-3-hours-late-output-fraction-in-the-evaluation-of-hydronephrosis-in-children
#17
Carlos J R Simal
OBJECTIVE: Dynamic renal scintigraphy complemented by late gravity assisted postvoid images to 60 minutes is a frequently used diagnostic test in the evaluation of hydrone¬phrosis. The objective of this study is to evaluate the effectiveness in acquiring images at 180 minutes to calculate the late output fraction (LOF) of 99mTc-DTPA in the diagnosis of ureteropelvic junction obstruction (UPJO). MATERIALS AND METHODS: A retrospective study of 177 patients (196 renal units) of suspected cases of clinical UPJO was conducted...
January 26, 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29344743/response-to-different-furosemide-doses-predicts-aki-progression-in-icu-patients-with-elevated-plasma-ngal-levels
#18
Ryo Matsuura, Yohei Komaru, Yoshihisa Miyamoto, Teruhiko Yoshida, Kohei Yoshimoto, Rei Isshiki, Kengo Mayumi, Tetsushi Yamashita, Yoshifumi Hamasaki, Masaomi Nangaku, Eisei Noiri, Naoto Morimura, Kent Doi
BACKGROUND: Furosemide responsiveness (FR) is determined by urine output after furosemide administration and has recently been evaluated as a furosemide stress test (FST) for predicting severe acute kidney injury (AKI) progression. Although a standardized furosemide dose is required for FST, variable dosing is typically employed based on illness severity, including renal dysfunction in the clinical setting. This study aimed to evaluate whether FR with different furosemide doses can predict AKI progression...
January 17, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29327197/-new-kidney-function-tests-renal-functional-reserve-and-furosemide-stress-test
#19
REVIEW
D Kindgen-Milles, T Slowinski, T Dimski
Acute kidney injury (AKI) occurs in 30-50% of all intensive care patients. Renal replacement therapy (RRT) has to be initiated in 10-15%. The early in-hospital mortality is about 50%. Up to 20% of all survivors develop chronic kidney disease after intensive care discharge and progress to end-stage kidney disease within the next 10 years. For timely initiation of prophylactic or therapeutic interventions, it is crucial to exactly determine the actual kidney function, i. e., glomerular filtration rate (GFR), and to gain insight into the further development of kidney function...
January 11, 2018: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://www.readbyqxmd.com/read/29319776/hypercalcemia-and-acute-renal-insufficiency-following-use-of-a-veterinary-supplement
#20
Marcelo Fernando Ronsoni, Heloisa de Cassia Dos Santos, Bruno da Silveira Colombo, Carina Gabriela Correa, Ana Paula Gomes Moritz, Marisa Helena Cesar Coral, Simone Van de Sande-Lee, Alexandre Hohl
A previously healthy 24 yo male presented with a two-month history of epigastric pain, nausea, vomiting, fatigue and malaise. He reported abuse of different substances, including an injectable veterinary vitamin compound, which contains high doses of vitamin A, D and E, and an oily vehicle that induces local edema and enhances muscle volume. Serum creatinine was 3.1 mg/dL, alanine transaminase 160 mg/dL, aspartate transaminase 11 mg/dL, total testosterone 23 ng/dL, 25-OH-vitamin D >150 ng/mL (toxicity >100), 1,25-OH-vitamin D 80 pg/mL, vitamin A 0...
October 2017: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
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