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https://www.readbyqxmd.com/read/29196148/circulating-il-17-producing-mucosal-associated-invariant-t-cells-mait-are-associated-with-symptoms-in-children-with-asthma
#1
Guillaume Lezmi, Rola Abou Taam, Céline Dietrich, Lucienne Chatenoud, Jacques de Blic, Maria Leite-de-Moraes
IL-17 and mucosal-associated invariant T (MAIT) cells have been involved in asthma pathogenesis. However, IL-17-producing MAIT cells (MAIT-17) were not evidenced. We aimed to determine whether circulating MAIT-17 were detectable in children with asthma, and whether they correlated with asthma symptoms or lung function. Children from the SPASM cohort of preschoolers with severe wheeze were reassessed for asthma at school age, and categorized as exacerbators (1 or more severe exacerbations in the previous 12months) or non-exacerbators...
November 28, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/29151195/risk-factors-in-preschool-children-for-predicting-asthma-during-the-preschool-age-and-the-early-school-age-a-systematic-review-and-meta-analysis
#2
REVIEW
Yixia Bao, Zhimin Chen, Enmei Liu, Li Xiang, Deyu Zhao, Jianguo Hong
PURPOSE OF REVIEW: The aim of this study was to identify risk factors of asthma among children < 6 years old (preschool age) for predicting asthma during the preschool age and early school age (≤ 10 years of age). METHOD OF THE STUDY: MEDLINE, Cochrane, EMBASE, and Google Scholar databases were searched until June 30, 2017. Prospective or retrospective cohort and case-control studies were included. Studies had to have evaluated risk factors or a predictive model for developing asthma in children ≤ 6 years of age or persistent asthma in early school age...
November 18, 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/29101282/a-population-based-prospective-cohort-study-examining-the-influence-of-early-life-respiratory-tract-infections-on-school-age-lung-function-and-asthma
#3
Evelien R van Meel, Herman T den Dekker, Niels J Elbert, Pauline W Jansen, Henriëtte A Moll, Irwin K Reiss, Johan C de Jongste, Vincent W V Jaddoe, Liesbeth Duijts
BACKGROUND: Early-life respiratory tract infections could affect airway obstruction and increase asthma risk in later life. However, results from previous studies are inconsistent. OBJECTIVE: We examined the associations of early-life respiratory tract infections with lung function and asthma in school-aged children. METHODS: This study among 5197 children born between April 2002 and January 2006 was embedded in a population-based prospective cohort study...
November 3, 2017: Thorax
https://www.readbyqxmd.com/read/29097430/temporal-stability-of-multitrigger-and-episodic-viral-wheeze-in-early-childhood
#4
Ben D Spycher, Cara Cochrane, Raquel Granell, Jonathan A C Sterne, Michael Silverman, Eva Pedersen, Erol A Gaillard, John Henderson, Claudia E Kuehni
The distinction between episodic viral wheeze (EVW) and multitrigger wheeze (MTW) is used to guide management of preschool wheeze. It has been questioned whether these phenotypes are stable over time. We examined the temporal stability of MTW and EVW in two large population-based cohorts.We classified children from the Avon Longitudinal Study of Parents and Children (n=10 970) and the Leicester Respiratory Cohorts ((LRCs), n=3263) into EVW, MTW and no wheeze at ages 2, 4 and 6 years based on parent-reported symptoms...
November 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28993393/recurrent-wheeze-and-its-relationship-with-lung-function-and-airway-inflammation-in-preschool-children-a-cross-sectional-study-in-south-korea
#5
Ji Eun Soh, Kyung-Moon Kim, Ji-Won Kwon, Hyung Young Kim, Ju-Hee Seo, Hyo-Bin Kim, So-Yeon Lee, Gwang-Cheon Jang, Dae-Jin Song, Woo Kyung Kim, Young-Ho Jung, Soo-Jong Hong, Jung Yeon Shim
BACKGROUND: Relationship between recurrent wheeze and airway function and inflammation in preschool children is not fully known. OBJECTIVE: To investigate the relationship between recurrent wheeze and airway inflammation, lung function, airway hyper-reactivity (AHR) and atopy in preschool children. DESIGN: Observational study, comparing forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and mid-forced expiratory flow (FEF25%-75%), dose-response slope (DRS), exhaled nitric oxide (eNO) and atopic sensitisation between children with recurrent wheeze and those without...
October 8, 2017: BMJ Open
https://www.readbyqxmd.com/read/28981187/defining-healthy-in-preschool-aged-children-for-forced-oscillation-technique-reference-equations
#6
Claire Shackleton, Dorottya Czovek, Keith Grimwood, Robert S Ware, Bence Radics, Zoltan Hantos, Peter D Sly
BACKGROUND AND OBJECTIVE: Selecting 'healthy' preschool-aged children for reference ranges may not be straightforward. Relaxing inclusion criteria for normative data does not affect spirometry z-scores. We therefore investigated the effect of similarly relaxing inclusion criteria in preschoolers on reference ranges for respiratory impedance (Zrs) using a modified forced oscillation technique (FOT). METHODS: The International Study of Asthma and Allergies in Childhood questionnaire classified 585 children into a healthy and five mutually exclusive groups...
October 5, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28941773/exploring-the-associations-between-parent-reported-biological-indoor-environment-and-airway-related-symptoms-and-allergic-diseases-in-children
#7
Alisa Weber, Nina Fuchs, Susanne Kutzora, Lana Hendrowarsito, Uta Nennstiel-Ratzel, Erika von Mutius, Caroline Herr, Stefanie Heinze
OBJECTIVES: Asthma and allergic rhinitis are diseases which require special attention in childhood. Risk factors for these diseases are manifold and include environmental factors. Previous studies have shown associations between indoor mould and respiratory diseases in children. Besides indoor mould, organic waste storage, potted plants, pets and crowding could influence the microbial indoor environment at home and the respiratory health of children. Our aim was therefore to explore the associations of these factors with airway-related symptoms and respiratory diseases in preschoolers...
November 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/28938840/first-episode-of-preschool-wheeze-requiring-hospitalization-a-prospective-study-on-the-chance-of-recurrence-and-associated-factors
#8
Karaked Chantawarangul, Jitladda Deerojanawong, Suchada Sritippayawan
BACKGROUND: Although wheezing is very common in preschoolers, epidemiologic studies in Thailand are quite limited. The likelihood of having a second wheezing episode following the first attack remains unclearly established. OBJECTIVES: This study aims to investigate the incidence of recurrent wheezing in preschool children presenting with first wheezing episode and identify the associated factors. METHODS: The study is an observational prospective study conducted at the inpatient pediatric department...
September 17, 2017: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/28853398/around-the-world-preschool-wheeze
#9
Heidi Makrinioti, Robert Klaber, Mando Watson
No abstract text is available yet for this article.
September 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28843990/effect-of-diet-and-maternal-education-on-allergies-among-preschool-children-a-case-control-study
#10
Sandra Andrusaityte, Regina Grazuleviciene, Inga Petraviciene
INTRODUCTION: The prevalence of asthma and allergy has increased among children. This increase in prevalence might be related to dietary patterns. AIMS: The present epidemiological study investigated the relationship between the consumption of fruit, vegetables, nuts, meat and fish, and the prevalence of wheeze, asthma, and eczema among preschool children. METHODS: This nested case-control study included 1489 children aged 4-6 years and residing in Kaunas city, Lithuania...
November 2017: Environmental Research
https://www.readbyqxmd.com/read/28771627/treatment-of-preschool-children-presenting-to-the-emergency-department-with-wheeze-with-azithromycin-a-placebo-controlled-randomized-trial
#11
RANDOMIZED CONTROLLED TRIAL
Piush J Mandhane, Patricia Paredes Zambrano de Silbernagel, Yin Nwe Aung, Janie Williamson, Bonita E Lee, Sheldon Spier, Mary Noseworthy, William R Craig, David W Johnson
BACKGROUND: Antibiotics are frequently used to treat wheezing children. Macrolides may be effective in treating bronchiolitis and asthma. METHOD: We completed a prospective, double-blinded, randomized placebo-control trial of azithromycin among pre-school children (12 to 60 months of age) presenting to the emergency department with wheeze. Patients were randomized to receive either five days of azithromycin or placebo. Primary outcome was time to resolution of respiratory symptoms after treatment initiation...
2017: PloS One
https://www.readbyqxmd.com/read/28740854/clinical-implications-of-oscillatory-lung-function-during-methacholine-bronchoprovocation-testing-of-preschool-children
#12
Sun Hee Choi, Youn Ho Sheen, Mi Ae Kim, Ji Hyeon Baek, Hey Sung Baek, Seung Jin Lee, Jung Won Yoon, Yeong Ho Rha, Man Yong Han
OBJECTIVE: To investigate the repeatability and safety of measuring impulse oscillation system (IOS) parameters and the point of wheezing during bronchoprovocation testing of preschool children. METHODS: Two sets of methacholine challenge were conducted in 36 asthma children. The test was discontinued if there was a significant change in reactance (Xrs5) and resistance (Rrs5) at 5 Hz (Condition 1) or respiratory distress due to airway obstruction (Condition 2)...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28667045/fifteen-minute-consultation-an-evidence-based-approach-to-the-child-with-preschool-wheeze
#13
Renu Khetan, Matthew Hurley, Abraham Neduvamkunnil, Jayesh Mahendra Bhatt
Preschool wheeze is very common and its prevalence is increasing. It consumes considerable healthcare resources and has a major impact on children and their families due to significant morbidity associated with acute episodes.History taking is the main diagnostic instrument in the assessment of preschool wheeze. Diagnosis and management is complicated by a broad differential and associations with many other diseases and conditions that give rise to noisy breathing, which could be misinterpreted as wheeze. Several clinical phenotypes have been described but they have limitations and do not clearly inform therapeutic decisions...
June 30, 2017: Archives of Disease in Childhood. Education and Practice Edition
https://www.readbyqxmd.com/read/28658545/development-of-allergic-immunity-in-early-life
#14
REVIEW
Clare M Lloyd, Sejal Saglani
The growth and maturity of the peripheral immune system and subsequent development of pulmonary immunity in early life is dictated by host, environmental and microbial factors. Dysregulation during the critical window of immune development in the postnatal years results in disease which impacts on lifelong lung health. Asthma is a common disease in childhood and is often preceded by wheezing illnesses during the preschool years. However, the mechanisms underlying development of wheeze and how and why only some children progress to asthma is unknown...
July 2017: Immunological Reviews
https://www.readbyqxmd.com/read/28605217/differences-between-preschoolers-with-asthma-and-allergies-in-urban-and-rural-environments
#15
Daniel A Marfortt, Dario Josviack, Alejandro Lozano, Eduardo Cuestas, Luis Agüero, Jose A Castro-Rodriguez
OBJECTIVE: The influence of living in a rural or urban environment on asthma and allergic diseases in school-children provide conflicting results; moreover none of these studies included exclusively preschoolers. The aim of the present study was to evaluate if recurrent wheezing preschoolers from rural or urban areas differ in asthma, allergic diseases, and atopy. METHODS: A cross-sectional-study in Rafaela, Argentina, on 143 preschoolers with recurrent wheezing from rural and urban settings was performed (2010-2012)...
June 12, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28599066/rhinovirus-and-preschool-wheeze
#16
REVIEW
Katarina Stenberg-Hammar, Gunilla Hedlin, Cilla Söderhäll
Rhinovirus (RV) known as the common cold virus generally only causes a mild upper respiratory infection, but severe lower respiratory symptoms have been associated with RV infections especially in asthmatic individuals. Wheezing is a symptom of airway obstruction, and preschool children wheezing with RV have been associated with increased risk of asthma at school age. There are, however, conflicting opinions as to whether there are differences in response to RV infection or whether wheezing with RV reveals a preexisting impairment that promotes asthma mainly in predisposed children...
September 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28567533/a-meta-analysis-of-montelukast-for-recurrent-wheeze-in-preschool-children
#17
Hasan R Hussein, Atul Gupta, Simon Broughton, Gary Ruiz, Nicola Brathwaite, Cara J Bossley
There is conflicting evidence of the effectiveness of montelukast in preschool wheeze. A recent Cochrane review focused on its use in viral-induced wheeze; however, such subgroups are unlikely to exist in real life and change with time, recently highlighted in an international consensus report. We have therefore sought to investigate the effectiveness of montelukast in all children with preschool wheeze (viral-induced and multiple-trigger wheeze). The PubMed, Cochrane Library, Ovid Medline and Ovid EMBASE were screened for randomised controlled trials (RCTs), examining the efficacy of montelukast compared with placebo in children with the recurrent preschool wheeze...
July 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28503824/an-index-to-predict-asthma-in-wheezing-young-children-produced-promising-initial-results
#18
Bill Hesselmar, Robert Saalman, Göran Wennergren, Mainor Åmark, Agnes E Wold, Ingegerd Adlerberth, Nils Åberg
No abstract text is available yet for this article.
May 15, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28440062/predictive-value-of-serum-sst2-in-preschool-wheezers-for-development-of-asthma-with-high-feno
#19
M E Ketelaar, K D van de Kant, F N Dijk, E M Klaassen, N S Grotenboer, M C Nawijn, E Dompeling, G H Koppelman
Wheezing is common in childhood. However, current prediction models of pediatric asthma have only modest accuracy. Novel biomarkers and definition of subphenotypes may improve asthma prediction. Interleukin-1-receptor-like-1 (IL1RL1 or ST2) is a well-replicated asthma gene and associates with eosinophilia. We investigated whether serum sST2 predicts asthma and asthma with elevated exhaled NO (FeNO), compared to the commonly used Asthma Prediction Index (API). Using logistic regression modeling, we found that serum sST2 levels in 2-3 years-old wheezers do not predict doctors' diagnosed asthma at age 6 years...
April 25, 2017: Allergy
https://www.readbyqxmd.com/read/28410872/prevalence-and-risk-factors-for-wheezing-and-allergic-diseases-in-preschool-children-a-perspective-from-the-mediterranean-coast-of-turkey
#20
E Bolat, T Arikoglu, M A Sungur, S B Batmaz, S Kuyucu
OBJECTIVES: The aim of the present study was to determine the prevalence and risk factors of allergic diseases in preschool children from one of the biggest cities in the Mediterranean Region of Turkey. METHODS: The study population included 396 preschool children attending to urban daycare centres in Mersin. In the first stage, a comprehensive standardised questionnaire modified from the International Study of Asthma and Allergies in Childhood (ISAAC) was employed...
July 2017: Allergologia et Immunopathologia
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