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https://www.readbyqxmd.com/read/29156486/-update-in-obstetric-anesthesia-tried-and-trusted-methods-controversies-and-new-perspectives
#1
Peter Kranke, Thorsten Annecke, Dorothee H Bremerich, Daniel Chappell, Thierry Girard, Wiebke Gogarten, Robert Hanß, Lutz Kaufner, Sophie Neuhaus, Tobias Ninke, Thomas Standl, Stefan Weber, Yvonne Jelting, Thomas Volk
Since 1975, a plethora of lectures within the context of annual meetings relevant for the clinical care has been summarized in "what's new in obstetric anesthesia" by the society for Obstetric anesthesia and Perinatology which can be recommended to everyone interested in anaesthesiology in the delivery room. After the death of Gerard W. Ostheimer, Professor of Anaesthesiology at Brigham and Women's Hospital in Boston, Massachusetts, it became renamed the Gerard W. Ostheimer "what's new in obstetric anesthesia" lecture to honor his contributions to regional anesthesia and obstetric anaesthesia...
November 2017: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
https://www.readbyqxmd.com/read/29155348/progress-and-challenges-of-predictive-biomarkers-of-anti-pd-1-pd-l1-immunotherapy-a-systematic-review
#2
Feifei Teng, Xiangjiao Meng, Li Kong, Jinming Yu
Despite the marked success of applications of PD-1/PD-L1 checkpoint blockades in clinical, the efficacy and responsiveness of these agents varies greatly among different tumor types and across individual patients. Therefore, establishment of predictive biomarkers for checkpoint blockades is of the most importance to maximize the therapeutic benefits. In this review, we discuss the current progress and challenges of developing predictive biomarkers of immunotherapy responsiveness, aiming to provide some directions for future studies...
November 16, 2017: Cancer Letters
https://www.readbyqxmd.com/read/29155307/sex-steroids-and-the-kidney-role-in-renal-calcium-and-phosphate-handling
#3
REVIEW
Rougin Khalil, Na-Ri Kim, Ferran Jardi, Dirk Vanderschueren, Frank Claessens, Brigitte Decallonne
Calcium and phosphate are vital for the organism and constitute essential components of the skeleton. Serum levels are tightly hormonally regulated and maintained by exchange with three major sources: the intestines, the kidney and the bone. The effects of sex steroids on the bone have been extensively studied and it is well known that sex steroid deficiency induces bone loss, indirectly influencing renal calcium and phosphate homeostasis. However, it is unknown whether sex steroids also directly regulate renal calcium and phosphate handling, hereby potentially indirectly impacting on bone...
November 16, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29155117/pediatric-non-missile-penetrating-head-injury-case-series-and-literature-review
#4
REVIEW
Evangelos Drosos, Dimitrios Giakoumettis, Alexandros Blionas, Andreas Mitsios, Georgios Sfakianos, Marios Themistocleous
BACKGROUND: Pediatric non-missile penetrating head injury (NMPHI) is usually accidental attributed mainly to the softer skulls of growing children. However, it is a rather rare entity and therefore no consensus exists regarding treatment, in order to effectively prevent the immediate and long-term complications. Throughout the literature practice, essentials are mostly discussed in case reviews and case series in general population. No data originating from randomized studies are available due to ethical and practical limitations...
November 15, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29155094/motivational-state-controls-the-prediction-error-in-pavlovian-appetitive-aversive-interactions
#5
Vincent Laurent, Bernard W Balleine, R Frederick Westbrook
Contemporary theories of learning emphasize the role of a prediction error signal in driving learning, but the nature of this signal remains hotly debated. Here, we used Pavlovian conditioning in rats to investigate whether primary motivational and emotional states interact to control prediction error. We initially generated cues that positively or negatively predicted an appetitive food outcome. We then assessed how these cues modulated aversive conditioning when a novel cue was paired with a foot shock. We found that a positive predictor of food enhances, whereas a negative predictor of that same food impairs, aversive conditioning...
November 16, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29154804/event-related-brain-potentials-and-the-study-of-reward-processing-methodological-considerations
#6
REVIEW
Olave E Krigolson
There is growing interest in using electroencephalography and specifically the event-related brain potential (ERP) methodology to study human reward processing. Since the discovery of the feedback related negativity (Miltner et al., 1997) and the development of theories associating the feedback related negativity and more recently the reward positivity with reinforcement learning, midbrain dopamine function, and the anterior cingulate cortex (i.e., Holroyd and Coles, 2002) researchers have used the ERP methodology to probe the neural basis of reward learning in humans...
November 14, 2017: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/29154653/symbolic-number-skills-predict-growth-in-nonsymbolic-number-skills-in-kindergarteners
#7
Ian M Lyons, Stephanie Bugden, Samuel Zheng, Stefanie De Jesus, Daniel Ansari
There is currently considerable discussion about the relative influences of evolutionary and cultural factors in the development of early numerical skills. In particular, there has been substantial debate and study of the relationship between approximate, nonverbal (approximate magnitude system [AMS]) and exact, symbolic (symbolic number system [SNS]) representations of number. Here we examined several hypotheses concerning whether, in the earliest stages of formal education, AMS abilities predict growth in SNS abilities, or the other way around...
November 20, 2017: Developmental Psychology
https://www.readbyqxmd.com/read/29154633/disentangling-inhibition-based-and-retrieval-based-aftereffects-of-distractors-cognitive-versus-motor-processes
#8
Tarini Singh, Ruth Laub, Jan Pablo Burgard, Christian Frings
Selective attention refers to the ability to selectively act upon relevant information at the expense of irrelevant information. Yet, in many experimental tasks, what happens to the representation of the irrelevant information is still debated. Typically, 2 approaches to distractor processing have been suggested, namely distractor inhibition and distractor-based retrieval. However, it is also typical that both processes are hard to disentangle. For instance, in the negative priming literature (for a review Frings, Schneider, & Fox, 2015) this has been a continuous debate since the early 1980s...
November 20, 2017: Journal of Experimental Psychology. Human Perception and Performance
https://www.readbyqxmd.com/read/29154622/how-does-not-left-become-right-electrophysiological-evidence-for-a-dynamic-conflict-bound-negation-processing-account
#9
Carolin Dudschig, Barbara Kaup
Human thought and language is traditionally considered as abstract, amodal, and symbolic. However, recent theories propose that high-level human cognition is directly linked to basic, modal biological systems such as sensorimotor areas. Despite this influential representational debate very little is known regarding whether the mechanisms involved in sensorimotor control are also shared with higher-level cognitive processes, such as language comprehension. We investigated negation as a universal of human language, addressing two key questions: (a) Does negation result in a conflict-like representation? (b) Does negation trigger executive control adjustments in a similar manner as standard information processing conflicts do (e...
November 20, 2017: Journal of Experimental Psychology. Human Perception and Performance
https://www.readbyqxmd.com/read/29154600/a-passionate-call-for-dispassionate-conclusion-comment-on-fossati-et-al-2016
#10
Joshua D Miller, Donald R Lynam
In a recent article published by Fossati and colleagues (2016a, 2016b), the authors compared the empirical profiles derived from correlating measures of narcissism and narcissistic personality disorder (NPD) with a measure of the 25 personality disorder traits included in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5; American Psychiatric Association, 2013) to an expert-rated profile of NPD. The initial data, which included some mistakes, were interpreted as indicating comparable performance across all three self-report measures of narcissism and NPD, including two hotly debated measures, the Narcissistic Personality Inventory (NPI) and the Pathological Narcissism Inventory (PNI)...
November 2017: Psychological Assessment
https://www.readbyqxmd.com/read/29154512/laparoscopic-vs-open-approach-for-pt3-pt4-colorectal-cancer-in-the-elderly-ten-year-experience-in-a-single-center
#11
Marina Troian, Gabriele Bellio, Arianna Pasquali, Nicolò DE Manzini
BACKGROUND: The role of laparoscopic surgery for pT3/pT4 colorectal cancer (CRC) is still under debate. The aim of this study was to compare the outcomes of laparoscopic and open procedures for pT3/pT4 CRC in elderly patients. METHODS: From January 2004 to December 2015, 225 patients aged ≥ 70 years underwent elective colorectal surgery for pT3/pT4 CRC at the Department of General Surgery, University Hospital of Trieste. Patients' demographics, tumor's characteristics, intraoperative factors, short- term and long-term outcomes were retrospectively analyzed...
November 20, 2017: Minerva Chirurgica
https://www.readbyqxmd.com/read/29154211/quasi-static-and-dynamic-motions-of-the-columellar-footplate-in-ostrich-struthio-camelus-measured-ex%C3%A2-vivo
#12
Pieter G G Muyshondt, Raf Claes, Peter Aerts, Joris J J Dirckx
The nature of the movement of the columellar footplate (CFP) in birds is still a matter of ongoing debate. Some sources claim that rocking motion is dominant, while others propose a largely piston-like motion. In this study, motions of the CFP are experimentally investigated in the ostrich using a post-mortem approach. For quasi-static loads, micro-CT scans of ostrich heads were made under positive and negative middle-ear pressures of 1 kPa. For dynamic loads, laser Doppler vibrometry was used to measure the velocity on multiple locations of the CFP as a function of excitation frequency from 0...
November 9, 2017: Hearing Research
https://www.readbyqxmd.com/read/29153864/changes-in-markers-of-thrombin-generation-and-interleukin-6-during-unicondylar-knee-and-total-knee-arthroplasty
#13
Edwin P Su, Lauren E Mount, Allina A Nocon, Thomas P Sculco, George Go, Nigel E Sharrock
BACKGROUND: Total knee arthroplasty (TKA) is associated with a risk of thromboembolism requiring routine thromboprophylaxis, but there is debate about the risk with unicondylar knee arthroplasty (UKA) as it is a more minor procedure. We sought to investigate the relative risk of thromboembolism with UKA compared to TKA and one-staged bilateral TKA (BTKA) by measuring the increase in circulating biochemical markers of thrombin generation during the procedures. Degree of surgical trauma was also assessed by measuring interleukin-6, a marker of metabolic injury...
October 16, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29153078/the-use-and-impact-of-twitter-at-medical-conferences-best-practices-and-twitter-etiquette
#14
REVIEW
Naveen Pemmaraju, Ruben A Mesa, Navneet S Majhail, Michael A Thompson
The use of social media, and in particular, Twitter, for professional use among healthcare providers is rapidly increasing across the world. One medical subspecialty that is leading the integration of this new platform for communication into daily practice and for information dissemination to the general public is the field of hematology/oncology. A growing amount of research in this area demonstrates that there is increasing interest among physicians to learn not only how to use social media for consumption of educational material, but also how to generate and contribute original content in one's interest/expert areas...
October 2017: Seminars in Hematology
https://www.readbyqxmd.com/read/29152815/harder-better-faster-%C3%A2-yet-stronger-working-conditions-and-self-declaration-of-chronic-diseases
#15
Éric Defebvre
The role played by working conditions in worker health status has been widely acknowledged in the literature in general but has received less attention in economics, due to the inherent statistical biases and lack of data available to determine the role of simultaneous and chronic exposures. This study aims to estimate the causal impact of detrimental working conditions on the self-declaration of chronic diseases in France. Using a rebuilt retrospective lifelong panel and defining indicators for physical and psychosocial strains, I implement a mixed econometric strategy that relies on difference-in-differences and matching methods to take into account for selection biases as well as unobserved heterogeneity...
November 20, 2017: Health Economics
https://www.readbyqxmd.com/read/29152812/focus-on-cryptomarkets-and-online-reviews-too-narrow-to-debate-harms-of-drugs-bought-online
#16
Daan van der Gouwe, Sander Rigter, Tibor Markus Brunt
No abstract text is available yet for this article.
November 19, 2017: Addiction
https://www.readbyqxmd.com/read/29152515/should-copyright-be-transferred-before-a-manuscript-is-accepted
#17
Jaime A Teixeira da Silva
Academic journals that undergo a process of academic scrutiny often pass a stage of peer review and subsequent editorial approval. In a process that can take weeks or months (in some cases, even years), an author aims to satisfy the requirements of peer reviewer and editorial scrutiny that would merit publication of their work. It is customary to, in traditional, non-open access journals, to then sign over copyright to the publisher, upon which the publisher then issues a proof, and the manuscript is then published...
October 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29152497/molecular-analysis-driven-video-assisted-thoracic-surgery-resections-in-bilateral-synchronous-lung-cancers-from-the-test-tube-to-the-operatory-room
#18
REVIEW
Sergio Nicola Forti Parri, Barbara Bonfanti, Alessandra Cancellieri, Dario De Biase, Rocco Trisolini, Stefania Zoboli, Luca Bertolaccini, Piergiorgio Solli, Giovanni Tallini
Synchronous cancers are not such rare clinical conditions. Nevertheless, even after the 8th edition of the TNM classification of the lung cancer, the surgical approach for patients presenting with synchronous bilateral lung cancer is still under debate. The resection of both lesions in the case of synchronous bilateral lung cancer is reasonable, but, on the other hand, is the lobectomy the correct choice in the event of the single primary with a contralateral metastatic lesion? In this case report, we describe how the molecular analysis and the detection of the EGFR, KRAS and TP53 mutations in both tumours have determined in a patient the two tumours as primary and both the right surgical approach...
October 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29152475/use-of-robotics-in-liver-donor-right-hepatectomy
#19
REVIEW
Po-Da Chen, Chao-Yin Wu, Yao-Ming Wu
Liver transplantation is the best solution for end stage liver disease, and has been widely accepted and rapidly developed in the past decades. Along with the improved outcomes of liver transplantation, living-related donor transplantation has been conducted to overcome the shortage of the deceased donor. The most important aspects of the living-related liver transplantation are donor safety and fast recovery after graft procurement. Meanwhile, the rapid progress of minimally invasive surgery (MIS) in general surgery has generated heated debate regarding the appropriateness of MIS in living-related donor graft hepatectomy...
October 2017: Hepatobiliary Surgery and Nutrition
https://www.readbyqxmd.com/read/29152138/the-hoct1-and-abcb1-polymorphisms-do-not-influence-the-pharmacodynamics-of-nilotinib-in-chronic-myeloid-leukemia
#20
Sara Galimberti, Cristina Bucelli, Elena Arrigoni, Claudia Baratè, Susanna Grassi, Federica Ricci, Francesca Guerrini, Elena Ciabatti, Carmen Fava, Antonio D'Avolio, Giulia Fontanelli, Giovanna Rege Cambrin, Alessandro Isidori, Federica Loscocco, Giovanni Caocci, Marianna Greco, Monica Bocchia, Lara Aprile, Antonella Gozzini, Barbara Scappini, Daniele Cattaneo, Anna Rita Scortechini, Giorgio La Nasa, Alberto Bosi, Pietro Leoni, Romano Danesi, Giuseppe Saglio, Giuseppe Visani, Agostino Cortelezzi, Mario Petrini, Alessandra Iurlo, Antonello Di Paolo
First-line nilotinib in chronic myeloid leukemia is more effective than imatinib to achieve early and deep molecular responses, despite poor tolerability or failure observed in one-third of patients. The toxicity and efficacy of tyrosine kinase inhibitors might depend on the activity of transmembrane transporters. However, the impact of transporters genes polymorphisms in nilotinib setting is still debated. We investigated the possible correlation between single nucleotide polymorphisms of hOCT1 (rs683369 [c...
October 20, 2017: Oncotarget
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