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https://www.readbyqxmd.com/read/28927240/temporal-dynamics-of-hippocampal-and-medial-prefrontal-cortex-interactions-during-the-delay-period-of-a-working-memory-guided-foraging-task
#1
Maxym Myroshnychenko, Jeremy K Seamans, Anthony G Phillips, Christopher C Lapish
Connections between the hippocampus (HC) and medial prefrontal cortex (mPFC) are critical for working memory; however, the precise contribution of this pathway is a matter of debate. One suggestion is that it may stabilize retrospective memories of recently encountered task-relevant information. Alternatively, it may be involved in encoding prospective memories, or the internal representation of future goals. To explore these possibilities, simultaneous extracellular recordings were made from mPFC and HC of rats performing the delayed spatial win-shift on a radial maze...
September 12, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28927174/has-invasive-management-for-acute-coronary-syndromes-become-more-risk-appropriate-pooled-results-of-five-australian-registries
#2
Amera Halabi, Derek P Chew, Matthew Horsfall, Karice Huyn, Andrew MacIsaac, Craig Juergens, John Amerena, Jamie Rankin, John French, David Brieger
Background: Despite being recommended in acute coronary syndrome (ACS) guidelines, the use of invasive management within specific risk groups continues to be debated. This study examines the change in the use of invasive management in ACS by patient risk and the associated change in mortality within Australia over the last 17 years. Methods: Pooled cohorts derived from five ACS registries (ACACIA, CONCORDANCE, GRACE, Snapshot-ACS, and Predict) spanned from 1999 to 2015...
April 1, 2017: European Heart Journal. Quality of Care & Clinical Outcomes
https://www.readbyqxmd.com/read/28927066/utility-of-percutaneous-radiofrequency-ablation-alone-or-combined-with-transarterial-chemoembolization-for-early-hepatocellular-carcinoma
#3
Tsutomu Tamai, Akihiko Oshige, Kazuaki Tabu, Eriko Tabu, Syo Ijyuin, Haruka Sakae, Hiroka Onishi, Kaori Muromachi, Akiko Saisyoji, Kohei Oda, Kotaro Kumagai, Seiichi Mawatari, Akihiro Moriuchi, Kazuhiro Sakurai, Tsuyoshi Hori, Akio Ido
Percutaneous radiofrequency ablation (RFA) combined with transarterial chemoembolization (TACE) is an effective, standard therapy against small hepatocellular carcinoma (HCC). However, there is debate regarding the effectiveness of RFA combined with TACE (RFA/TACE) compared with RFA alone. These two approaches were compared for the treatment of early HCC. The present study examined 83 HCC tumors in 83 patients treated with RFA between April 2007 and August 2014 at three medical institutions. All HCCs were single hypervascular tumors, with a median diameter of 16 mm (range, 6-30 mm)...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28926951/insights-into-the-hexose-liver-metabolism-glucose-versus-fructose
#4
REVIEW
Bettina Geidl-Flueck, Philipp A Gerber
High-fructose intake in healthy men is associated with characteristics of metabolic syndrome. Extensive knowledge exists about the differences between hepatic fructose and glucose metabolism and fructose-specific mechanisms favoring the development of metabolic disturbances. Nevertheless, the causal relationship between fructose consumption and metabolic alterations is still debated. Multiple effects of fructose on hepatic metabolism are attributed to the fact that the liver represents the major sink of fructose...
September 16, 2017: Nutrients
https://www.readbyqxmd.com/read/28926882/-diagnostic-criteria-of-demodex-blepharitis
#5
L Y Liang, J Li, Y Liu
Demodex infestation is a common cause of blepharitis and now is drawing more and more attention from clinicians. Demodex mite is the most common age-related ectoparasite of human being and may be detected from asymptomatic normal population. Furthermore, the pathogenesis of demodicosis remains unclear. Therefore, the commonly accepted diagnostic criteria of demodex infestation related blepharitis have not been established. Herein, we summarize the related studies about ocular demodicosis and comment the debates about the diagnosis of the disease...
September 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28926820/guided-university-debate-effect-of-a-new-teaching-learning-strategy-for-undergraduate-nursing-students
#6
Marta Arrue, Saloa Unanue, David Merida
BACKGROUND: A number of studies have shown that the traditional lecture suffers from limitations in the development of many important competencies such as reasoning ability for nursing professionals. OBJECTIVES: In view of this issue, the authors present a promising alternative to the traditional lecture: the Guided University Debate (GUD). With regard to this aim a teaching-learning sequence of schizophrenia is described based on the GUD. Next, the improvement in the argumentative and declarative knowledge of the students who have participated in the said methodology is demonstrated...
September 5, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/28926776/the-impact-of-price-policy-on-demand-for-alcohol-in-rural-india
#7
Arjunan Subramanian, Parmod Kumar
Whether raising the price of addictive goods can reduce its burden is widely debated in many countries, largely due to lack of appropriate data and robust methods. Three key concerns frequently raised in the literature are: unobserved heterogeneity; omitted variables; identification problem. Addressing these concerns, using robust instrument and employing unique individual-level panel data from Indian Punjab, this paper investigates two related propositions (i) will increase in alcohol price reduce its burden (ii) since greater incomes raise the costs of inebriation, will higher incomes affect consumption of alcohol negatively...
August 24, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28926749/the-use-of-care-robots-in-aged-care-a-systematic-review-of-argument-based-ethics-literature
#8
REVIEW
Tijs Vandemeulebroucke, Bernadette Dierckx de Casterlé, Chris Gastmans
BACKGROUND: As care robots become more commonplace in aged-care settings, the ethical debate on their use becomes increasingly important. Our objective was to examine the ethical arguments and underlying concepts used in the ethical debate on care robot use in aged care. METHODS: We conducted a systematic literature search for argument-based ethics publications focusing on care robot use in aged-care practices. We used an innovative methodology that consisted of three steps: (a) identifying conceptual-ethical questions, (b) conducting a literature search, and (c) identifying, describing and analyzing the ethical arguments in connection with the conceptual-ethical questions...
September 6, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28926396/live-or-let-die-new-developments-in-the-ongoing-debate-over-mannequin-death
#9
Aaron W Calhoun, David M Gaba
No abstract text is available yet for this article.
September 18, 2017: Simulation in Healthcare: Journal of the Society for Simulation in Healthcare
https://www.readbyqxmd.com/read/28926307/predictive-utility-of-personality-disorder-in-depression-comparison-of-outcomes-and-taxonomic-approach
#10
Giles Newton-Howes, Roger Mulder, Pete M Ellis, Joseph M Boden, Peter Joyce
There is debate around the best model for diagnosing personality disorder, both in terms of its relationship to the empirical data and clinical utility. Four randomized controlled trials examining various treatments for depression were analyzed at an individual patient level. Three different approaches to the diagnosis of personality disorder were analyzed in these patients. A total of 578 depressed patients were included in the analysis. Personality disorder, however measured, was of little predictive utility in the short term but added significantly to predictive modelling of medium-term outcomes, accounting for more than twice as much of the variance in social functioning outcome as depression psychopathology...
September 19, 2017: Journal of Personality Disorders
https://www.readbyqxmd.com/read/28926245/hno-is-produced-by-the-reaction-of-no-with-thiols
#11
Sebastian A Suarez, Martina Muñoz, Lucia Alvarez, Mateus F Venancio, Willian Rocha, Damian E Bikiel, Marcelo A Marti, Fabio Doctorovich
Azanone (nitroxyl, HNO) is a highly reactive compound whose biological role is still a matter of debate. One possible route for its formation is NO reduction by biological reductants. These reactions have been historically discarded due to the negative redox potential for the NO,H+/HNO couple. However, the NO to HNO conversion mediated by vitamins C, E and aromatic alcohols has been recently shown to be feasible from a chemical standpoint. Based on these precedents we decided to study the reaction of NO with thiols as potential sources of HNO...
September 19, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28926225/bridging-bio-nano-science-and-cancer-nanomedicine
#12
Mattias Björnmalm, Kristofer J Thurecht, Michael Michael, Andrew M Scott, Frank Caruso
The interface of bio-nano science and cancer medicine is an area experiencing much progress but also beset with controversy. Core concepts of the field-e.g., the enhanced permeability and retention (EPR) effect, tumor targeting and accumulation, and even the purpose of "nano" in cancer medicine-are hotly debated. In parallel, considerable advances in neighboring fields are occurring rapidly, including the recent progress of "immuno-oncology" and the fundamental impact it is having on our understanding and the clinical treatment of the group of diseases collectively known as cancer...
September 19, 2017: ACS Nano
https://www.readbyqxmd.com/read/28926023/the-political-economy-of-bovine-tuberculosis-in-great-britain
#13
R M Bennett
A brief history of bovine tuberculosis (bTB) and its control in Great Britain (GB) is presented. Numerous diverse policies to control the disease in humans, cattle and wildlife have been pursued over the last 100 years and many millions of pounds have been spent. After notable success in reducing the incidence and prevalence of bTB in cattle in GB from the 1950s to the mid-1980s, the geographical spread of the disease and the number of cattle slaughtered have increased continually since that time, with a high point of bTB incidence in 2008...
April 2017: Revue Scientifique et Technique
https://www.readbyqxmd.com/read/28925860/pharmacologic-and-perioperative-considerations-for-antihypertensive-medications
#14
Sher-Lu Pai, Ryan M Chadha, Joan M Irizarry Alvarado, Johnathan Ross Renew, Stephen Aniskevich
BACKGROUND: As the prevalence of hypertension continues to increase, physicians routinely encounter patients preoperatively receiving one or more cardiovascular medications to manage hypertension. Thus, the physician's knowledge of perioperative antihypertensive medication management is crucial to ensure patient safety. OBJECTIVE: We discuss the decisions to continue or stop antihypertensive medications to reduce the risk of perioperative complications. METHOD: We conducted a review of the original research studies, review articles, and editorials present on PubMed within the past 60 years...
September 18, 2017: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/28925537/continental-extent-patterns-in-amphibian-malformations-linked-to-parasites-chemical-contaminants-and-their-interactions
#15
Sarah E Haas, Mari K Reeves, Alfred E Pinkney, Pieter T J Johnson
Widespread observations of malformed amphibians across North America have generated both concern and controversy. Debates over the causes of such malformations-which can affect >50% of animals in a population-have continued, likely due to involvement of multiple causal factors. Here, we used a 13-year dataset encompassing 53,880 frogs and toads from 422 wetlands and 42 states in the conterminous USA to test hypotheses relating abnormalities and four categories of potential drivers: (1) chemical contaminants, (2) land use practices, (3) parasite infection, and (4) targeted interactions between parasites and pesticides...
September 19, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28924872/-alzheimer-s-disease-from-auguste-deter-to-the-present-progress-disappointments-and-open-questions
#16
REVIEW
Johannes Pantel
AIM: The present article aims to provide a short overview of the discovery history, conceptual development, as well as on current neurobiological and pharmacological research questions in the field of Alzheimer's disease (AD). In view of the long hoped for but so far unachieved therapeutic breakthrough, this also includes a critical reflection of current research paradigms. MATERIAL AND METHODS: Starting from the first case report described by Alois Alzheimer in 1906, the historical impact of his seminal discovery is reconstructed...
September 18, 2017: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/28924729/dor-vs-toupet-fundoplication-after-laparoscopic-heller-myotomy-long-term-randomized-controlled-trial-evaluated-by-high-resolution-manometry
#17
Gonzalo Torres-Villalobos, Enrique Coss-Adame, Janette Furuzawa-Carballeda, Fernanda Romero-Hernández, Blanca Blancas-Breña, Samuel Torres-Landa, Axel Palacios-Ramírez, Edgar Alejandro-Medrano, Axel Hernández-Ávila, Athenea Flores-Najera, Lourdes Margarita Ávila Escobedo, Cecilia Ramírez Angulo, Angélica Rodríguez-Garcés, Miguel Ángel Valdovinos
BACKGROUND: Laparoscopic Heller myotomy (LHM) with partial fundoplication is an effective treatment for achalasia. However, the type of fundoplication is still a subject of debate. AIM: The aim of the study is to identify which partial fundoplication leads to better control of acid exposure, manometric parameters, and symptoms scores. METHODS: A randomized controlled trial was performed to compare Dor vs Toupet fundoplication after LHM. The preoperative diagnosis was made by high-resolution manometry (HRM), upper endoscopy, and barium esophagogram...
September 18, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28924601/incidental-colorectal-focal-18-f-fdg-uptake-a-novel-indication-for-colonoscopy
#18
Eugénie Rigault, Laurence Lenoir, Guillaume Bouguen, Mael Pagenault, Astrid Lièvre, Etienne Garin, Laurent Siproudhis, Jean-François Bretagne
BACKGROUND AND STUDY AIMS:  The relevance of incidental colorectal focal (18) F-FDG PET/CT uptake is debatable. All patients who were referred for colonoscopy because of incidental colonic focal FDG uptake were included in this retrospective study. PATIENTS AND METHODS:  PET/CT imaging characteristics were reviewed by a nuclear physician who was blinded to endoscopic and histopathological findings to determine the location of FDG uptake sites and to measure the maximum standardized uptake values (SUVmax) and metabolic volume (MV)...
September 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28924446/use-of-intravitreal-dexamethasone-in-a-case-of-anterior-ischemic-optic-neuropathy
#19
Raffaele Nuzzi, Francesca Monteu
Nowadays there is no unique and well-established treatment for nonarteritic anterior ischemic optic neuropathy, despite being the main acute pathology that affects the optic nerve in the elderly population and often resulting in a significant loss of visual acuity. The effectiveness of oral steroids is still under debate in the international literature, although many studies show that patients treated with high doses of systemic corticosteroids have a significantly higher chance of improved visual acuity and visual fields...
May 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28924431/occult-hepatitis-infection-in-transfusion-medicine-screening-policy-and-assessment-of-current-use-of-anti-hbc-testing
#20
REVIEW
Antonella Esposito, Chiara Sabia, Carmela Iannone, Giovanni F Nicoletti, Linda Sommese, Claudio Napoli
HBV still represents a global risk factor in transfusion medicine. The residual risk of HBV is not limited to pre-seroconversion window period but it extends to donors with occult HBV infection (OBI) characterized by the presence of HBV DNA in liver and by the absence of the virus surface antigen. Each country developed an appropriate blood screening policy according to local HBV prevalence, yields of infectious units per different screening methods and cost-effectiveness. We underline the need of maintaining a high level of attention for OBI carrier identification in all blood banks worldwide where the screening procedures are generally based on a combination of both serological markers and nucleic acid amplification test...
August 2017: Transfusion Medicine and Hemotherapy
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