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https://www.readbyqxmd.com/read/29761863/surgical-treatment-of-esophageal-cancer-in-the-era-of-multimodality-management
#1
REVIEW
Alicia S Borggreve, B Feike Kingma, Serg A Domrachev, Mikhail A Koshkin, Jelle P Ruurda, Richard van Hillegersberg, Flavio R Takeda, Lucas Goense
Over the last decades, the treatment of resectable esophageal cancer has evolved into a multidisciplinary process in which all players are essential for treatment to be successful. Medical oncologists and radiation oncologists have been increasingly involved since the implementation of neoadjuvant therapy, which has been shown to improve survival. Although esophagectomy is still considered the cornerstone of curative treatment for locally advanced esophageal cancer, it remains associated with considerable postoperative morbidity, despite promising results of minimally invasive techniques...
May 15, 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29663405/a-career-path-for-pure-academic-medical-physicists-in-radiation-oncology-should-be-established
#2
Ke Sheng, Todd Pawlicki, Jing Cai
Medical physics research has led to many advanced radiation oncology technologies in the past decades, such as intensity modulated radiation therapy (IMRT), stereotactic body radiation therapy (SBRT), and proton therapy. These have fundamentally shaped the current landscape of cancer treatment. It is believed that medical physics research will continue to play an essential role in advancing radiation oncology in the future. However, sustaining a healthy medical physics research workforce is facing substantial challenges, such as limited funding support and lack of protected research time...
April 16, 2018: Medical Physics
https://www.readbyqxmd.com/read/29490601/posterior-shoulder-tightness-to-treat-or-not-to-treat
#3
Kevin Hall, John D Borstad
Shoulder pain is a common musculoskeletal complaint that is difficult to treat because of the biomechanical complexity of the shoulder region, the interplay between mobility and stability, and the vital role played by the shoulder in moving, positioning, and providing stability for hand function. Despite advances in biomechanics and pain science, there is still much to learn about how impairments influence shoulder function and health. One impairment, posterior shoulder tightness (PST), is often noted in individuals with shoulder pain and consequently has generated much discussion and debate in recent years...
March 2018: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/29488311/why-prescribe-exercise-as-therapy-in-type-2-diabetes-we-have-a-pill-for-that
#4
REVIEW
Mathias Ried-Larsen, Christopher S MacDonald, Mette Y Johansen, Katrine B Hansen, Robin Christensen, Thomas P Almdal, Bente K Pedersen, Kristian Karstoft
The majority of T2D cases are preventable through a healthy lifestyle, leaving little room for questions that lifestyle should be the first line of defence in the fight against the development of T2D. However, when it comes to the clinical care of T2D, the potential efficacy of lifestyle is much less clear-cut, both in terms of impacting the pathological metabolic biomarkers of the disease, and long-term complications. A healthy diet, high leisure-time physical activity, and exercise are considered to be cornerstones albeit adjunct to drug therapy in the management of T2D...
February 28, 2018: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29471855/phase-based-treatment-versus-immediate-trauma-focused-treatment-in-patients-with-childhood-trauma-related-posttraumatic-stress-disorder-study-protocol-for-a-randomized-controlled-trial
#5
Noortje I van Vliet, Rafaele J C Huntjens, Maarten K van Dijk, Ad de Jongh
BACKGROUND: The treatment of posttraumatic stress disorder (PTSD) related to a history of sexual and/or physical abuse in childhood is the subject of international debate, with some favouring a phase-based approach as their preferred treatment, while others argue for immediate trauma-focused treatment. A history of (chronic) traumatisation during childhood has been linked to the development of distinct symptoms that are often labelled as symptoms of complex PTSD. Many therapists associate the presence of symptoms of complex PTSD with a less favourable treatment prognosis...
February 22, 2018: Trials
https://www.readbyqxmd.com/read/29335037/is-freedom-still-therapy-the-40th-anniversary-of-the-italian-mental-health-care-reform
#6
A Fioritti
On 13 May 1978, the Italian Parliament approved Law 180, universally known as 'Basaglia Law' after the name of the leader of the anti-institutional movement which promoted this radical community mental health care reform. Forty years later, Italian psychiatry still runs a community care system, albeit with degrees of solidity and quality very varied along the peninsula. Mental health care is still an integral part of the National Health System, with liberal regulations on coercion and a lowest number of general hospital and residential facilities beds...
January 16, 2018: Epidemiology and Psychiatric Sciences
https://www.readbyqxmd.com/read/29202162/controversial-issues-in-healthcare-policy-a-survey-of-doctor-of-physical-therapy-students-in-a-public-university
#7
Drew D Snyder, Teale K Bennett, Jeremy C Oller, Weiqing Ge
BACKGROUND: The recently passed legislation and proposed policy changes governing the healthcare system have been met with extensive debate and controversy. OBJECTIVE: The primary objective of the study was to determine the attitudes of Doctor of Physical Therapy (DPT) students towards some of these controversial issues. The secondary objective was to determine the demographic factors, including number of years in a physical therapy program, that contribute to their attitude formation...
2017: Journal of Allied Health
https://www.readbyqxmd.com/read/29174931/group-1-epidemiology-of-primary-and-secondary-adrenal-insufficiency-prevalence-and-incidence-acute-adrenal-insufficiency-long-term-morbidity-and-mortality
#8
Olivier Chabre, Bernard Goichot, Delphine Zenaty, Jérôme Bertherat
The prevalence of primary adrenal insufficiency is estimated at between 82-144/million, with auto-immunity being the most common cause in adults and genetic causes, especially enzyme defects, being the most common cause in children. The prevalence of secondary adrenal deficiency is estimated to be between 150-280/million. The most frequent occurrence is believed to be corticosteroid-induced insufficiency, despite the incidence of clinically relevant deficiency after cessation of glucocorticoid treatment being widely debated...
December 2017: Annales D'endocrinologie
https://www.readbyqxmd.com/read/29164924/towards-enhanced-pet-quantification-in-clinical-oncology
#9
REVIEW
Habib Zaidi, Nicolas Karakatsanis
Positron emission tomography (PET) has, since its inception, established itself as the imaging modality of choice for the in vivo quantitative assessment of molecular targets in a wide range of biochemical processes underlying tumour physiology. PET image quantification enables to ascertain a direct link between the time-varying activity concentration in organs/tissues and the fundamental parameters portraying the biological processes at the cellular level being assessed. However, the quantitative potential of PET may be affected by a number of factors related to physical effects, hardware and software system specifications, tracer kinetics, motion, scan protocol design and limitations in current image-derived PET metrics...
January 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29147847/r-hyper-cvad-versus-r-chop-cytarabine-with-high-dose-therapy-and-autologous-haematopoietic-stem-cell-support-in-fit-patients-with-mantle-cell-lymphoma-20-years-of-single-center-experience
#10
COMPARATIVE STUDY
Fabienne Widmer, Stefan Balabanov, Davide Soldini, Panagiotis Samaras, Bernhard Gerber, Markus G Manz, Jeroen S Goede
Standard of care for untreated mantle cell lymphoma (MCL) is still debated. At the University Hospital Zurich, advanced MCL in physically fit patients is treated either with rituximab plus cyclophosphamide, doxorubicin, vincristine and prednisone induction followed by consolidating high-dose chemotherapy and autologous stem cell support (R-CHOP/HD-ASCT), or with rituximab plus fractionated cyclophosphamide, vincristine, doxorubicin and dexamethasone alternating with high-dose methotrexate-cytarabine (R-hyper-CVAD/MTX-AraC) without consolidating HD-ASCT upon physicians' and patients' choice...
February 2018: Annals of Hematology
https://www.readbyqxmd.com/read/29105700/-seeking-compulsory-treatment-as-life-saving-in-the-presence-of-eating-disorders-a-complex-choice
#11
Walter Milano, Armando Cotugno, Riccardo Dalle Grave, Maria Gabriella Gentile, Giovanni Gravina, Caterina Renna, Pierandrea Salvo, Patrizia Todisco, Lorenzo Maria Donini
Eating disorders (and especially anorexia nervosa) are associated with severe disability, poor quality of life and high mortality rate. Anorexia nervosa ranks among the main causes of death among young women. Despite physical and psycho-social impairment, patients suffering from anorexia nervosa do not recognize low body weight and extreme calorie restriction as a clinical problem and are ambivalent towards treatment. Some patients with anorexia nervosa refuse treatments though presenting severe medical complications and having a high mortality risk...
September 2017: Rivista di Psichiatria
https://www.readbyqxmd.com/read/29043889/unconventional-treatments-for-chronic-inflammatory-demyelinating-polyneuropathy
#12
Yusuf A Rajabally
This article focuses on the unconventional treatments used in chronic inflammatory demyelinating polyneuropathy (CIDP). First line, evidence-based treatments for CIDP include corticosteroids, immunoglobulins and plasma exchanges. Several unproven treatments are however given in treatment-refractory disease or to reduce requirements in validated therapies for reasons of side effects/practical delivery/cost. Despite methodological issues, IFN-α, azathioprine and methotrexate have not been shown to be useful in randomized controlled trials...
October 2017: Neurodegenerative Disease Management
https://www.readbyqxmd.com/read/28961620/physician-assistant-doctorate-a-ticket-to-autonomy
#13
Anthony A Miller, Bettie Coplan
As the physician assistant (PA) profession celebrates 5 decades of practice, questions about the future direction of PA education and practice persist. Conversations regarding prescribing privileges have given way to debate about PA certification and the necessary level of PA education. Most PA programs already confer master's degrees, but there has been at times vigorous debate on whether or not the PA profession should join pharmacy (PharmD), physical therapy (DPT), and advanced practice nursing (DNP) and standardize education at the clinical doctorate level...
October 2017: Journal of Physician Assistant Education
https://www.readbyqxmd.com/read/28941509/current-management-of-subcondylar-fractures-of-the-mandible-including-endoscopic-repair
#14
REVIEW
Alexis M Strohl, Robert M Kellman
Treatment of subcondylar fractures has been the subject of debate for many years. Options for treatment include physical therapy, elastic maxillomandibular fixation, and open repair. Proper imaging and clinical evaluation are imperative when deciding on the best management option. In the past, most subcondylar fractures were treated with a closed approach. Recent data support open repair, when feasible. Studies show increased interincisal opening, lateral excursion, and protrusion with less mandibular shortening, jaw deviation, and pain...
November 2017: Facial Plastic Surgery Clinics of North America
https://www.readbyqxmd.com/read/28922992/policy-maker-attitudes-to-the-ageing-of-the-hiv-cohort-in-botswana
#15
Kabo Matlho, Refelwetswe Lebelonyane, Tim Driscoll, Joel Negin
BACKGROUND: The roll out of antiretroviral therapy in Botswana, as in many countries with near universal access to treatment, has transformed HIV into a complex yet manageable chronic condition and has led to the emergence of a population aging with HIV. Although there has been some realization of this development at international level, no clear defined intervention strategy has been established in many highly affected countries. Therefore we explored attitudes of policy-makers and service providers towards HIV among older adults (50 years or older) in Botswana...
December 2017: SAHARA J: Journal of Social Aspects of HIV/AIDS Research Alliance
https://www.readbyqxmd.com/read/28826292/radiobiological-issues-in-proton-therapy
#16
REVIEW
Radhe Mohan, Christopher R Peeler, Fada Guan, Lawrence Bronk, Wenhua Cao, David R Grosshans
The relative biological effectiveness (RBE) for particle therapy is a complex function of particle type, radiation dose, linear energy transfer (LET), cell type, endpoint, etc. In the clinical practice of proton therapy, the RBE is assumed to have a fixed value of 1.1. This assumption, along with the effects of physical uncertainties, may mean that the biologically effective dose distributions received by the patient may be significantly different from what is seen on treatment plans. This may contribute to unforeseen toxicities and/or failure to control the disease...
November 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28793863/cardiovascular-risk-and-dyslipidemia-among-persons-living-with-hiv-a-review
#17
REVIEW
Paolo Maggi, Antonio Di Biagio, Stefano Rusconi, Stefania Cicalini, Maurizio D'Abbraccio, Gabriella d'Ettorre, Canio Martinelli, Giuseppe Nunnari, Laura Sighinolfi, Vincenzo Spagnuolo, Nicola Squillace
BACKGROUND: Aim of this review is to focus the attention on people living with HIV infection at risk of developing a cardiovascular event. What is or what would be the most suitable antiretroviral therapy? Which statin or fibrate to reduce the risk? How to influence behavior and lifestyles? DISCUSSION: Prevention of cardiovascular disease (CVD) risk remains the first and essential step in a medical intervention on these patients. The lifestyle modification, including smoking cessation, increased physical activity, weight reduction, and the education on healthy dietary practices are the main instruments...
August 9, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28782277/long-term-outcome-of-intractable-constipation-treated-by-sacral-neuromodulation-a-comparison-between-children-and-adults
#18
P T J Janssen, Y M Meyer, S M J Van Kuijk, M A Benninga, L P S Stassen, N D Bouvy, J Melenhorst, S O Breukink
AIM: Sacral neuromodulation (SNM) is a minimally invasive therapy for functional constipation (FC) and is most often used to treat adults. Recent studies suggest that SNM may also beneficial in children. However, comparative data regarding preferred age of SNM for FC are lacking. Therefore, long-term results of SNM for FC were compared between children and adults. METHOD: All patients treated with SNM for FC between 2004 and 2015 were evaluated. Outcomes of children (age 10-18 years) were compared with those for adults (≥ 18 years)...
February 2018: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28680503/adenomatous-tumors-of-the-middle-ear-a-literature-review
#19
REVIEW
Flavia Amarante Cardoso, Eduardo Machado Rossi Monteiro, Livia Bernardi Lopes, Marianna Novaes da Costa Avila, Bernardo Oliveira Scarioli
Introduction  Neuroendocrine adenomas of the middle ear (NAME) are uncommon causes of middle ear masses. Mostly limited to case reports and small series, the literature is poor in providing an overall assessment of these tumors. Objective  To review the current literature about all aspects of the disease, including its etiology, clinical manifestations, diagnosis, and treatment. Data Synthesis  The pathogenesis of adenomatous tumors of the middle ear is not clear yet. One potential explanation is that an undifferentiated pluripotent endodermal stem cell may still be present in the middle ear mucosal surface, and may be the origin of the tumors...
July 2017: International Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/28567339/hallux-rigidus-how-do-i-approach-it
#20
REVIEW
Aaron Lam, Jimmy J Chan, Michele F Surace, Ettore Vulcano
Hallux rigidus is a degenerative disease of the first metatarsalphalangeal (MTP) joint and affects 2.5% of people over age 50. Dorsal osteophytes and narrowed joint space leads to debilitating pain and limited range of motion. Altered gait mechanics often ensued as 119% of the body force transmit through the 1st MTP joint during gait cycle. Precise etiology remains under debate with trauma being often cited in the literature. Hallux valgus interphalangeus, female gender, inflammatory and metabolic conditions have all been identified as associative factors...
May 18, 2017: World Journal of Orthopedics
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