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https://www.readbyqxmd.com/read/29147847/r-hyper-cvad-versus-r-chop-cytarabine-with-high-dose-therapy-and-autologous-haematopoietic-stem-cell-support-in-fit-patients-with-mantle-cell-lymphoma-20%C3%A2-years-of-single-center-experience
#1
Fabienne Widmer, Stefan Balabanov, Davide Soldini, Panagiotis Samaras, Bernhard Gerber, Markus G Manz, Jeroen S Goede
Standard of care for untreated mantle cell lymphoma (MCL) is still debated. At the University Hospital Zurich, advanced MCL in physically fit patients is treated either with rituximab plus cyclophosphamide, doxorubicin, vincristine and prednisone induction followed by consolidating high-dose chemotherapy and autologous stem cell support (R-CHOP/HD-ASCT), or with rituximab plus fractionated cyclophosphamide, vincristine, doxorubicin and dexamethasone alternating with high-dose methotrexate-cytarabine (R-hyper-CVAD/MTX-AraC) without consolidating HD-ASCT upon physicians' and patients' choice...
November 16, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/29105700/-seeking-compulsory-treatment-as-life-saving-in-the-presence-of-eating-disorders-a-complex-choice
#2
Walter Milano, Armando Cotugno, Riccardo Dalle Grave, Maria Gabriella Gentile, Giovanni Gravina, Caterina Renna, Pierandrea Salvo, Patrizia Todisco, Lorenzo Maria Donini
Eating disorders (and especially anorexia nervosa) are associated with severe disability, poor quality of life and high mortality rate. Anorexia nervosa ranks among the main causes of death among young women. Despite physical and psycho-social impairment, patients suffering from anorexia nervosa do not recognize low body weight and extreme calorie restriction as a clinical problem and are ambivalent towards treatment. Some patients with anorexia nervosa refuse treatments though presenting severe medical complications and having a high mortality risk...
September 2017: Rivista di Psichiatria
https://www.readbyqxmd.com/read/29043889/unconventional-treatments-for-chronic-inflammatory-demyelinating-polyneuropathy
#3
Yusuf A Rajabally
This article focuses on the unconventional treatments used in chronic inflammatory demyelinating polyneuropathy (CIDP). First line, evidence-based treatments for CIDP include corticosteroids, immunoglobulins and plasma exchanges. Several unproven treatments are however given in treatment-refractory disease or to reduce requirements in validated therapies for reasons of side effects/practical delivery/cost. Despite methodological issues, IFN-α, azathioprine and methotrexate have not been shown to be useful in randomized controlled trials...
October 18, 2017: Neurodegenerative Disease Management
https://www.readbyqxmd.com/read/28961620/physician-assistant-doctorate-a-ticket-to-autonomy
#4
Anthony A Miller, Bettie Coplan
As the physician assistant (PA) profession celebrates 5 decades of practice, questions about the future direction of PA education and practice persist. Conversations regarding prescribing privileges have given way to debate about PA certification and the necessary level of PA education. Most PA programs already confer master's degrees, but there has been at times vigorous debate on whether or not the PA profession should join pharmacy (PharmD), physical therapy (DPT), and advanced practice nursing (DNP) and standardize education at the clinical doctorate level...
October 2017: Journal of Physician Assistant Education
https://www.readbyqxmd.com/read/28941509/current-management-of-subcondylar-fractures-of-the-mandible-including-endoscopic-repair
#5
REVIEW
Alexis M Strohl, Robert M Kellman
Treatment of subcondylar fractures has been the subject of debate for many years. Options for treatment include physical therapy, elastic maxillomandibular fixation, and open repair. Proper imaging and clinical evaluation are imperative when deciding on the best management option. In the past, most subcondylar fractures were treated with a closed approach. Recent data support open repair, when feasible. Studies show increased interincisal opening, lateral excursion, and protrusion with less mandibular shortening, jaw deviation, and pain...
November 2017: Facial Plastic Surgery Clinics of North America
https://www.readbyqxmd.com/read/28922992/policy-maker-attitudes-to-the-ageing-of-the-hiv-cohort-in-botswana
#6
Kabo Matlho, Refelwetswe Lebelonyane, Tim Driscoll, Joel Negin
BACKGROUND: The roll out of antiretroviral therapy in Botswana, as in many countries with near universal access to treatment, has transformed HIV into a complex yet manageable chronic condition and has led to the emergence of a population aging with HIV. Although there has been some realization of this development at international level, no clear defined intervention strategy has been established in many highly affected countries. Therefore we explored attitudes of policy-makers and service providers towards HIV among older adults (50 years or older) in Botswana...
December 2017: SAHARA J: Journal of Social Aspects of HIV/AIDS Research Alliance
https://www.readbyqxmd.com/read/28826292/radiobiological-issues-in-proton-therapy
#7
Radhe Mohan, Christopher R Peeler, Fada Guan, Lawrence Bronk, Wenhua Cao, David R Grosshans
The relative biological effectiveness (RBE) for particle therapy is a complex function of particle type, radiation dose, linear energy transfer (LET), cell type, endpoint, etc. In the clinical practice of proton therapy, the RBE is assumed to have a fixed value of 1.1. This assumption, along with the effects of physical uncertainties, may mean that the biologically effective dose distributions received by the patient may be significantly different from what is seen on treatment plans. This may contribute to unforeseen toxicities and/or failure to control the disease...
November 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28793863/cardiovascular-risk-and-dyslipidemia-among-persons-living-with-hiv-a-review
#8
REVIEW
Paolo Maggi, Antonio Di Biagio, Stefano Rusconi, Stefania Cicalini, Maurizio D'Abbraccio, Gabriella d'Ettorre, Canio Martinelli, Giuseppe Nunnari, Laura Sighinolfi, Vincenzo Spagnuolo, Nicola Squillace
BACKGROUND: Aim of this review is to focus the attention on people living with HIV infection at risk of developing a cardiovascular event. What is or what would be the most suitable antiretroviral therapy? Which statin or fibrate to reduce the risk? How to influence behavior and lifestyles? DISCUSSION: Prevention of cardiovascular disease (CVD) risk remains the first and essential step in a medical intervention on these patients. The lifestyle modification, including smoking cessation, increased physical activity, weight reduction, and the education on healthy dietary practices are the main instruments...
August 9, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28782277/long-term-outcome-of-intractable-constipation-treated-by-sacral-neuromodulation-a-comparison-between-children-and-adults
#9
Paul T J Janssen, Yannick M Meyer, Sander M J Van Kuijk, Marc A Benninga, Laurents P S Stassen, Nicole D Bouvy, Jarno Melenhorst, Stephanie O Breukink
AIM: Sacral neuromodulation (SNM) is a minimal invasive therapy for functional-constipation (FC) and is most often used to treat adults. Recent studies suggest that SNM may also beneficial in children. However, comparative data regarding preferred age of SNM for FC are lacking. Therefore, long-term results of SNM for FC were compared between children and adults. METHOD: All patients treated with SNM for FC between 2004 and 2015 were evaluated. Outcomes of children (age 10-18 years) were compared with adults (≥18 years)...
August 7, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28680503/adenomatous-tumors-of-the-middle-ear-a-literature-review
#10
REVIEW
Flavia Amarante Cardoso, Eduardo Machado Rossi Monteiro, Livia Bernardi Lopes, Marianna Novaes da Costa Avila, Bernardo Oliveira Scarioli
Introduction  Neuroendocrine adenomas of the middle ear (NAME) are uncommon causes of middle ear masses. Mostly limited to case reports and small series, the literature is poor in providing an overall assessment of these tumors. Objective  To review the current literature about all aspects of the disease, including its etiology, clinical manifestations, diagnosis, and treatment. Data Synthesis  The pathogenesis of adenomatous tumors of the middle ear is not clear yet. One potential explanation is that an undifferentiated pluripotent endodermal stem cell may still be present in the middle ear mucosal surface, and may be the origin of the tumors...
July 2017: International Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/28567339/hallux-rigidus-how-do-i-approach-it
#11
REVIEW
Aaron Lam, Jimmy J Chan, Michele F Surace, Ettore Vulcano
Hallux rigidus is a degenerative disease of the first metatarsalphalangeal (MTP) joint and affects 2.5% of people over age 50. Dorsal osteophytes and narrowed joint space leads to debilitating pain and limited range of motion. Altered gait mechanics often ensued as 119% of the body force transmit through the 1(st) MTP joint during gait cycle. Precise etiology remains under debate with trauma being often cited in the literature. Hallux valgus interphalangeus, female gender, inflammatory and metabolic conditions have all been identified as associative factors...
May 18, 2017: World Journal of Orthopedics
https://www.readbyqxmd.com/read/28503714/depression-severity-and-concentration-difficulties-are-independently-associated-with-hrqol-in-patients-with-unipolar-depressive-disorders
#12
A Fattori, L Neri, A Bellomo, M Vaggi, C Mencacci
PURPOSE: Cognitive impairment is a core feature of major depressive disorder (MDD), and dysfunctions in this area strongly contribute to MDD-associated disability. Whether cognitive impairment has an independent clinical course and a unique impact on HRQOL is still debated. We sought to characterize the relationship between depression severity and HRQOL, evaluating the burden of concentration difficulties on HRQOL. METHODS: Six hundred ninety-two patients with unipolar depressive disorders recruited in 19 Italian centers answered a self-administered survey (SF-12 questionnaire, socio-demographic information)...
May 13, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28478897/one-stage-surgical-treatment-for-concomitant-rotator-cuff-tears-with-shoulder-stiffness-has-comparable-results-with-isolated-rotator-cuff-tears-a-systematic-review
#13
REVIEW
Soheil Sabzevari, Amir Reza Kachooei, Juan Giugale, Albert Lin
BACKGROUND: Addressing preoperative shoulder stiffness before rotator cuff repair (RCR) is advocated, but the effectiveness of this approach is debatable. We hypothesized that 1-stage treatment of concomitant rotator cuff tear (RCT) with shoulder stiffness has comparable results with isolated RCT. METHODS: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, the databases including MEDLINE, Embase, Cochrane Library, and Scopus were searched using the keywords of "shoulder stiffness" OR "adhesive capsulitis" OR "frozen shoulder" AND "rotator cuff...
August 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28461966/management-of-the-first-episode-of-traumatic-shoulder-dislocation
#14
REVIEW
Michele Boffano, Stefano Mortera, Raimondo Piana
Shoulder joint dislocation is the most common joint dislocation seen in the emergency department.Traumatic dislocation may cause damage to the soft-tissues surrounding the shoulder joint and sometimes to the bone. The treatment, which aims at restoration of a fully functioning, pain-free and stable shoulder, includes either conservative or surgical management preceded by closed reduction of the acute dislocation.Conservative management usually requires a period of rest, generally involving immobilisation of the arm in a sling, even though it is still debated whether to immobilise the shoulder in internal or external rotation...
February 2017: EFORT open reviews
https://www.readbyqxmd.com/read/28460140/thyroid-function-variation-in-the-normal-range-energy-expenditure-and-body-composition-in-l-t4-treated-subjects
#15
Mary H Samuels, Irina Kolobova, Megan Antosik, Meike Niederhausen, Jonathan Q Purnell, Kathryn G Schuff
Purpose: It is not clear whether upper limits of the thyrotropin (TSH) reference range should be lowered. This debate can be better informed by investigation of whether variations in thyroid function within the reference range have clinical effects. Thyroid hormone plays a critical role in determining energy expenditure, body mass, and body composition, and therefore clinically relevant variations in these parameters may occur across the normal range of thyroid function. Methods: This was a cross-sectional study of 140 otherwise healthy hypothyroid subjects receiving chronic replacement therapy with levothyroxine (L-T4) who had TSH levels across the full span of the laboratory reference range (0...
July 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28456063/ocular-findings-in-adult-subjects-with-an-inactivating-mutation-in-gh-releasing-hormone-receptor-gene
#16
Augusto C N Faro, Virginia M Pereira-Gurgel, Roberto Salvatori, Viviane C Campos, Gustavo B Melo, Francielle T Oliveira, Alecia A Oliveira-Santos, Carla R P Oliveira, Francisco A Pereira, Ann Hellström, Luís A Oliveira-Neto, Eugenia H O Valença, Manuel H Aguiar-Oliveira
OBJECTIVE: Ocular function is fundamental for environmental adaptation and survival capacity. Growth factors are necessary for a mature eyeball, needed for adequate vision. However, the consequences of the deficiency of circulating growth hormone (GH) and its effector insulin-like growth factor I (IGF-I) on the physical aspects of the human eye are still debated. A model of untreated isolated GH deficiency (IGHD), with low but measurable serum GH, may clarify this issue. The aim of this study was to assess the ocular aspects of adult IGHD individuals who have never received GH therapy...
June 2017: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/28077019/independence-proposing-an-initial-framework-for-occupational-therapy
#17
Bethan Collins
BACKGROUND: The concept of independence is common in occupational therapy theory and practice but has rarely been clearly defined or conceptualized within in occupational therapy literature and there seems to be no standard definition. This can result in ambiguity, which potentially jeopardizes client-centred practice. AIM: This paper proposes an occupational therapy independence framework (OTIF) that synthesizes the range of characterizations of independence in a practically useful and occupation-centred manner...
November 2017: Scandinavian Journal of Occupational Therapy
https://www.readbyqxmd.com/read/28048338/we-de-202-00-connecting-radiation-physics-with-computational-biology
#18
Jan Schuemann
Radiation therapy for the treatment of cancer has been established as a highly precise and effective way to eradicate a localized region of diseased tissue. To achieve further significant gains in the therapeutic ratio, we need to move towards biologically optimized treatment planning. To achieve this goal, we need to understand how the radiation-type dependent patterns of induced energy depositions within the cell (physics) connect via molecular, cellular and tissue reactions to treatment outcome such as tumor control and undesirable effects on normal tissue...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047687/we-de-202-01-connecting-nanoscale-physics-to-initial-dna-damage-through-track-structure-simulations
#19
J Schuemann
Radiation therapy for the treatment of cancer has been established as a highly precise and effective way to eradicate a localized region of diseased tissue. To achieve further significant gains in the therapeutic ratio, we need to move towards biologically optimized treatment planning. To achieve this goal, we need to understand how the radiation-type dependent patterns of induced energy depositions within the cell (physics) connect via molecular, cellular and tissue reactions to treatment outcome such as tumor control and undesirable effects on normal tissue...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047038/we-de-202-02-are-track-structure-simulations-truly-needed-for-radiobiology-at-the-cellular-and-tissue-levels
#20
R Stewart
Radiation therapy for the treatment of cancer has been established as a highly precise and effective way to eradicate a localized region of diseased tissue. To achieve further significant gains in the therapeutic ratio, we need to move towards biologically optimized treatment planning. To achieve this goal, we need to understand how the radiation-type dependent patterns of induced energy depositions within the cell (physics) connect via molecular, cellular and tissue reactions to treatment outcome such as tumor control and undesirable effects on normal tissue...
June 2016: Medical Physics
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