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Antonio Fabiano Ferreira Filho, John Crown, Fatima Cardoso, Jean-Marie Nogaret, Karen Duffy, Stella Dolci, Susan Rowan, Niall O'Higgins, Veronique Batter, Marianne Paesmans, Martine J Piccart, Angelo Di Leo
BACKGROUND: Docetaxel has proven efficacy in metastatic breast cancer. In this pilot study, we explored the efficacy/feasibility of docetaxel-based sequential and combination regimens as adjuvant therapy of node-positive breast cancer. PATIENTS AND METHODS: From March 1996 till March 1998, four consecutive groups of patients with stages II and III breast cancer, aged < or = 70 years, received one of the following regimens: a) sequential Doxorubicin (A) --> Docetaxel (T) --> CMF (Cyclophosphamide+Methotrexate+5-Fluorouracil): A 75 mg/m q 3 wks x 3, followed by T100 mg/m2 q 3 wks x 3, followed by i...
July 2002: Anticancer Research
Christos Kosmas, Nicolas B Tsavaris, Thomas Makatsoris, Adimchi Onyenadum, Maria Vadiaka, Niki Stavroyianni, Evangelos Sepsas, Dimitris Dimitropoulos, Sofia Rokana, Haralambos P Kalofonos
In an attempt to develop more effective chemotherapy regimens in advanced nonsmall cell lung cancer (NSCLC), we evaluated docetaxel-ifosfamide-cisplatin (DIP) based on our previous experience with paclitaxel-ifosfamide-cisplatin. Patients with advanced NSCLC (stages III-IV), WHO-PS< or =2, no prior chemotherapy and unimpaired hematopoietic and organ function were eligible. Chemotherapy was administered in successive dose levels (DLs) and included docetaxel (80-100 mg/m2 day 1), ifosfamide (4-5 g/m2) and cisplatin (80-100 mg/m2), both divided over days 1 and 2 every 21 days...
March 1, 2002: International Journal of Cancer. Journal International du Cancer
F Cardoso, A F Ferreira Filho, J Crown, S Dolci, M Paesmans, A Riva, A Di Leo, M J Piccart
BACKGROUND: Doxorubicin (A) and Docetaxel (T) are amongst the most active agents in breast cancer treatment. The impact of drug sequencing is an issue still under evaluation. OBJECTIVE: To evaluate the feasibility and tolerability of two A and T-based sequential regimens, in which the sequence of drug administration was reversed. METHODS: The study included patients pts aged < or = 70 years, with operable node positive breast cancer. Two consecutive groups of patients received one of the following regimens: 1) Sequential A-->T-->CMF: Doxorubicin 75 mg/m2, i...
January 2001: Anticancer Research
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