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https://www.readbyqxmd.com/read/29474360/animal-versus-plant-protein-and-adult-bone-health-a-systematic-review-and-meta-analysis-from-the-national-osteoporosis-foundation
#1
Marissa M Shams-White, Mei Chung, Zhuxuan Fu, Karl L Insogna, Micaela C Karlsen, Meryl S LeBoff, Sue A Shapses, Joachim Sackey, Jian Shi, Taylor C Wallace, Connie M Weaver
BACKGROUND: Protein may have both beneficial and detrimental effects on bone health depending on a variety of factors, including protein source. OBJECTIVE: The aim was to conduct a systematic review and meta-analysis evaluating the effects of animal versus plant protein intake on bone mineral density (BMD), bone mineral content (BMC) and select bone biomarkers in healthy adults. METHODS: Searches across five databases were conducted through 10/31/16 for randomized controlled trials (RCTs) and prospective cohort studies in healthy adults that examined the effects of animal versus plant protein intake on 1) total body (TB), total hip (TH), lumbar spine (LS) or femoral neck (FN) BMD or TB BMC for at least one year, or 2) select bone formation and resorption biomarkers for at least six months...
2018: PloS One
https://www.readbyqxmd.com/read/29471120/the-4-n-acyl-and-4-n-alkyl-gemcitabine-analogues-with-silicon-fluoride-acceptor-application-to-18-f-radiolabeling
#2
Cesar Gonzalez, Andersson Sanchez, Jeffrey Collins, Ksenia Lisova, Jason T Lee, R Michael van Dam, M Alejandro Barbieri, Cheppail Ramachandran, Stanislaw F Wnuk
The coupling of gemcitabine with functionalized carboxylic acids using peptide coupling conditions afforded 4-N-alkanoyl analogues with a terminal alkyne or azido moiety. Reaction of 4-N-tosylgemcitabine with azidoalkyl amine provided 4-N-alkyl gemcitabine with a terminal azido group. Click reaction with silane building blocks afforded 4-N-alkanoyl or 4-N-alkyl gemcitabine analogues suitable for fluorination. RP-HPLC analysis indicated better chemical stability of 4-N-alkyl gemcitabine analogues versus 4-N-alkanoyl analogues in acidic aqueous conditions...
February 12, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29470854/the-cost-effectiveness-of-screening-in-the-community-to-reduce-osteoporotic-fractures-in-older-women-in-the-uk-economic-evaluation-of-the-scoop-study
#3
David A Turner, Rebekah Fong Soe Khioe, Lee Shepstone, Elizabeth Lenaghan, Cyrus Cooper, Neil Gittoes, Nicholas C Harvey, Richard Holland, Amanda Howe, Eugene McCloskey, Terence W O'Neill, David Torgerson, Richard Fordham
The SCOOP study was a two-arm randomized controlled trial conducted in the UK in 12,483 eligible women aged 70 to 85 years. It compared a screening program using the FRAX® risk assessment tool in addition to bone mineral density (BMD) measures versus usual management. The SCOOP study found a reduction in the incidence of hip fractures in the screening arm, but there was no evidence of a reduction in the incidence of all osteoporosis-related fractures. To make decisions about whether to implement any screening program, we should also consider whether the program is likely to be a good use of health care resources, ie, is it cost-effective? The cost per gained quality adjusted life year of screening for fracture risk has not previously been demonstrated in an economic evaluation alongside a clinical trial...
February 22, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29470715/issls-prize-in-bioengineering-science-2018-dynamic-imaging-of-degenerative-spondylolisthesis-reveals-mid-range-dynamic-lumbar-instability-not-evident-on-static-clinical-radiographs
#4
Malcolm E Dombrowski, Bryan Rynearson, Clarissa LeVasseur, Zach Adgate, William F Donaldson, Joon Y Lee, Ameet Aiyangar, William J Anderst
PURPOSE: Degenerative spondylolisthesis (DS) in the setting of symptomatic lumbar spinal stenosis is commonly treated with spinal fusion in addition to decompression with laminectomy. However, recent studies have shown similar clinical outcomes after decompression alone, suggesting that a subset of DS patients may not require spinal fusion. Identification of dynamic instability could prove useful for predicting which patients are at higher risk of post-laminectomy destabilization necessitating fusion...
February 22, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29469225/successful-hematopoietic-stem-cell-transplantation-for-osteopetrosis-using-reduced-intensity-conditioning
#5
Bella Shadur, Irina Zaidman, Adeeb NaserEddin, Elana Lokshin, Fatma Hussein, Hodaya Cohen Oron, Batia Avni, Sigal Grisariu, Polina Stepensky
BACKGROUND: Infantile malignant osteopetrosis (IMO) is an autosomal recessive condition characterized by defective osteoclast activity, with hematopoietic bone marrow transplant being the only available cure. Over the past several years, new conditioning regimes and donor options have emerged, thus extending the possibility of cure to a greater number of patients and improving the outcomes of bone marrow transplant. Here we detail the outcomes of bone marrow transplant in a cohort of 31 patients treated with a combination of fludarabine, treosulphan, thiotepa, and antithymocyte globulin...
February 22, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29469187/the-prediction-of-cyclic-proximal-humerus-fracture-fixation-failure-by-various-bone-density-measures
#6
Peter Varga, Leonard Grünwald, Markus Windolf
Fixation of osteoporotic proximal humerus fractures has remained challenging, but may be improved by careful pre-operative planning. The aim of this study was to investigate how well the failure of locking plate fixation of osteoporotic proximal humerus fractures can be predicted by bone density measures assessed with currently available clinical imaging (realistic case) and a higher resolution and quality modality (theoretical best-case). Various density measures were correlated to experimentally assessed number of cycles to construct failure of plated unstable low-density proximal humerus fractures (N = 18)...
February 22, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29468478/does-trabecular-bone-score-tbs-improve-the-predictive-ability-of-frax-%C3%A2-for-major-osteoporotic-fractures-according-to-the-japanese-population-based-osteoporosis-jpos-cohort-study
#7
Junko Tamaki, Masayuki Iki, Yuho Sato, Renaud Winzenrieth, Etsuko Kajita, Sadanobu Kagamimori
This study examined whether bone microarchitecture determined by Trabecular Bone Score (TBS) is associated with the risk of major osteoporotic fractures independent of FRAX® in Japanese women. Participants included 1541 women aged ≥ 40 at baseline. Major osteoporotic fractures during a 10-year follow-up period were documented by the Japanese Population-based Osteoporosis Cohort Study. TBS and areal bone mineral density (aBMD) were calculated for the same spinal regions at baseline. To compare the predictive ability of FRAX® model when used alone versus in combination with TBS, Akaike information criterion (AIC), the area under the receiver operating characteristic curve (AUC), net reclassification improvement (NRI), and integrated discrimination improvement (IDI) were calculated...
February 21, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29466057/zoledronic-acid-versus-alendronate-in-the-treatment-of-children-with-osteogenesis-imperfecta-a-2-year-clinical-study
#8
Fang Lv, Yi Liu, Xiaojie Xu, Yuwen Song, Lujiao Li, Yan Jiang, Ou Wang, Weibo Xia, Xiaoping Xing
OBJECTIVE: Bisphosphonates have been demonstrated to increase the bone mineral density (BMD) of osteogenesis imperfecta (OI) patients. We aimed to compare the efficacy and safety of intravenous zoledronic acid and oral alendronate in patients with OI. METHODS: A total of 161 patients with OI ranging from 2 to 16 years old were included and randomized at a 2:1 ratio to receive either weekly oral alendronate (ALN) 70 mg or a once-yearly infusion of zoledronic acid (ZOL) for 2 years...
February 2018: Endocrine Practice
https://www.readbyqxmd.com/read/29463853/spina-bifida-predisposing-heterozygous-mutations-in-planar-cell-polarity-genes-and-zic2-reduce-bone-mass-in-young-mice
#9
Isabel R Orriss, Stuart Lanham, Dawn Savery, Nicholas D E Greene, Philip Stanier, Richard Oreffo, Andrew J Copp, Gabriel L Galea
Fractures are a common comorbidity in children with the neural tube defect (NTD) spina bifida. Mutations in the Wnt/planar cell polarity (PCP) pathway contribute to NTDs in humans and mice, but whether this pathway independently determines bone mass is poorly understood. Here, we first confirmed that core Wnt/PCP components are expressed in osteoblasts and osteoclasts in vitro. In vivo, we performed detailed µCT comparisons of bone structure in tibiae from young male mice heterozygous for NTD-associated mutations versus WT littermates...
February 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29462121/patient-mortality-in-geriatric-distal-femur-fractures
#10
Philip Myers, Patrick Laboe, Kory J Johnson, Peter D Fredericks, Renn J Crichlow, Dean C Maar, Timothy G Weber
OBJECTIVES: To estimate 1-year mortality rates in elderly patients who undergo operative treatment for distal femur fractures and identify potential risk factors for mortality. DESIGN: Retrospective chart review. SETTING: Level 1 and Level 2 trauma centers. PATIENTS/PARTICIPANTS: Two hundred eighty-three elderly patients (average age 76.0 years ± 9.8) who sustained distal femur fractures between 2002 and 2012. INTERVENTION: Fracture fixation of the distal femur...
March 2018: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/29462049/suprasternal-transcatheter-aortic-valve-replacement-in-patients-with-marginal-femoral-access
#11
Andy C Kiser, Thomas G Caranasos, Mark D Peterson, David M Holzhey, Philipp Kiefer, L Wiley Nifong, Michael A Borger
OBJECTIVE: Recently, the PARTNER 2A trial reported results of transcatheter aortic valve replacement versus surgical aortic valve replacement in 2032 intermediate-risk patients at 2 years. Two hundred thirty-six patients (24%) required an access route other than transfemoral. Compared with transfemoral and surgical aortic valve replacement, nontransfemoral transcatheter aortic valve replacement was associated with a numerically higher rate of death and disabling stroke at 30 days. This underscores the need for a better alternative surgical approach for patients with marginal femoral access...
February 17, 2018: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/29460805/incidence-of-metabolic-bone-disease-in-preterm-infants-of-birth-weight-1250-g-and-in-those-suffering-from-bronchopulmonary-dysplasia
#12
Paola Gaio, Giovanna Verlato, Marco Daverio, Maria Elena Cavicchiolo, Daniel Nardo, Alessandra Pasinato, Francesca de Terlizzi, Eugenio Baraldi
BACKGROUND & AIMS: Preterm infants are exposed to a higher risk of developing Metabolic Bone Disease (MBD) with an increased bone fragility, a higher fracture risk and a long-term reduced linear growth and childhood height. Monitoring bone growth has become mandatory in neonatology. Several risk factors have been identified among the population of extremely low birth weight infants, but we still do not know which is the real incidence of MBD since its evaluation is not routinely performed worldwide...
February 2018: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29460653/risk-of-osteoporosis-in-microscopic-colitis
#13
Signe Wildt, Lars K Munck, Sabine Becker, Helle Brockstedt, Ole K Bonderup, Mette F Hitz
OBJECTIVES: Patients with microscopic colitis (MC) have several risk factors for osteoporosis. The prevalence of osteopenia and osteoporosis in MC is unknown. The primary purpose of this study was to evaluate bone mineral status in MC. METHODS: Patients with MC and disease activity within the last 2 years were included. Bone turnover markers were analyzed and bone mineral density (BMD) was measured with Dual Energy X-ray Absorptiometry (DXA) at inclusion and after one year...
February 20, 2018: Postgraduate Medicine
https://www.readbyqxmd.com/read/29459600/comparative-study-of-patellar-tendon-graft-versus-hamstrings-graft-for-anterior-cruciate-ligament-reconstruction
#14
M A Faisal, A Z Chowdhury, I K Kundu, K N Arifeen, A S Ullah, C I Mahmud, O M Dastagir, M A Islam, M S Paul
Graft selection for primary anterior cruciate ligament reconstruction is very important part of knee stability. The purpose of this Qasi experimental study was to compare the clinical outcomes after ACL reconstruction using either a BPTB graft or a four-strand hamstrings graft and conducted from January 2012 to December 2013. Patients presented with a symptomatic unilateral ACL rupture who were underwent ACL reconstruction by using either BPTB or Hamstrings graft, IPD of Department of Orthopedics at Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka as well as in a private hospital in Dhaka, Bangladesh were selected as study population...
January 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29457963/3-t-mr-imaging-of-proximal-femur-microarchitecture-in-subjects-with-and-without-fragility-fracture-and-nonosteoporotic-proximal-femur-bone-mineral-density
#15
Gregory Chang, Chamith S Rajapakse, Cheng Chen, Arakua Welbeck, Kenneth Egol, Ravinder R Regatte, Punam K Saha, Stephen Honig
Purpose To determine if 3-T magnetic resonance (MR) imaging of proximal femur microarchitecture can allow discrimination of subjects with and without fragility fracture who do not have osteoporotic proximal femur bone mineral density (BMD). Materials and Methods Sixty postmenopausal women (30 with and 30 without fragility fracture) who had BMD T scores of greater than -2.5 in the hip were recruited. All subjects underwent dual-energy x-ray absorptiometry to assess BMD and 3-T MR imaging of the same hip to assess bone microarchitecture...
February 19, 2018: Radiology
https://www.readbyqxmd.com/read/29457246/randomized-controlled-prospective-clinical-trial-of-autologous-greater-omentum-free-graft-versus-autogenous-cancellous-bone-graft-in-radial-and-ulnar-fractures-in-miniature-breed-dogs
#16
Jennifer J Ree, Wendy I Baltzer, Sarah Nemanic
OBJECTIVE: To determine the rate of radiographic healing, complications, vascularization, and bone density after repair of radial and ulnar fractures in dogs <6 kg that were treated with an autogenous cancellous bone graft (BG) or free autologous omentum graft (OG). STUDY DESIGN: Prospective, randomized, controlled clinical trial with owners/radiologists blinded to treatment. ANIMALS: 25 dogs with naturally occurring traumatic radial/ulnar fractures...
February 19, 2018: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/29456530/donor-genotype-in-the-interleukin-7-receptor-%C3%AE-chain-predicts-risk-of-graft-versus-host-disease-and-cytomegalovirus-infection-after-allogeneic-hematopoietic-stem-cell-transplantation
#17
Katrine Kielsen, Christian Enevold, Carsten Heilmann, Henrik Sengeløv, Anders Elm Pedersen, Lars P Ryder, Klaus Müller
The efficacy of allogeneic hematopoietic stem cell transplantation (HSCT) is challenged by acute and chronic graft-versus-host disease (aGVHD and cGVHD) and viral infections due to long-lasting immunodeficiency. Interleukin-7 (IL-7) is a cytokine essential for de novo T cell generation in thymus and peripheral T cell homeostasis. In this study, we investigated the impact of the single nucleotide polymorphism rs6897932 in the IL-7 receptor α-chain (IL-7Rα) which has previously been associated with several autoimmune diseases...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29454548/correlation-between-molecular-tumor-volume-evaluated-with-68-ga-psma-pet-ct-and-prostatic-specific-antigen-levels
#18
S Medina-Ornelas Sevastián, O García-Pérez Francisco, Y Hernández-Pedro Norma, E Arellano-Zarate Angélica, L Abúndiz-López Blanca
OBJECTIVE: To investigate the association between prostatic-specific antigen (PSA) levels and molecular tumor volume (MTV) measured in the68 Ga-PSMA PET/CT, both done in a short period of time, in prostate cancer patients with biochemical failure. METHODS: Eighty-four patients who underwent68 Ga-PSMA PET/CT and measurement of PSA levels in the same week (trigger-PSA) were studied in this retrospective analysis. MTV was calculated from the sum of the metastatic lesions...
February 14, 2018: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/29453931/comparison-of-return-to-pre-injury-sport-after-10-mm-size-bone-patellar-tendon-bone-bptb-versus-8-mm-hamstring-anterior-cruciate-ligament-reconstruction-a-retrospective-study-with-a-two-year-follow-up
#19
Rimtautas Gudas, Rokas Jurkonis, Alfredas Smailys
BACKGROUND The aim of this study was to evaluate the reconstruction of a torn anterior cruciate ligament (ACL) with 10 mm diameter BPTB (bone-patellar tendon-bone) autograft versus 8 mm HT (hamstring tendon) autografts, to compare the ability to restore pre-injury sports activities and reduce revision risk after these procedures. MATERIAL AND METHODS A prospective clinical review was performed to compare results of patients who underwent primary anatomical ACLR with 10 mm BPTB autografts with patients who underwent 8 mm diameter HT autografts, between January 2011 and January 2014...
February 17, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29453620/long-term-hearing-results-of-stapedotomy-analysis-of-factors-affecting-outcome
#20
Dhooge Ingeborg, Desmedt Stéphanie, Maly Thomas, Loose David, Van Hoecke Helen
OBJECTIVE: To evaluate long-term hearing results of stapedotomy and analyze the influence of patient-, disease-, and procedure-related variables. STUDY DESIGN: Retrospective case series. SETTING: Tertiary referral center. PATIENTS: 230 ears (202 patients, 10-74 years) underwent stapedotomy for otosclerosis between January 2008 and August 2014. All cases had early postoperative follow-up (4 weeks post-surgery) and 181 cases had late postoperative follow-up (≥ 1 year, average 32...
February 16, 2018: European Archives of Oto-rhino-laryngology
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