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https://www.readbyqxmd.com/read/29679770/easy-to-read-informed-consent-form-for-hematopoietic-cell-transplantation-clinical-trials-results-from-bmt-ctn-1205-study
#1
Ryan Spellecy, Sergey Tarima, Ellen Denzen, Heather Moore, Sunil Abhyankar, Peter Dawson, Amy Foley, Iris Gersten, Mitchell Horwitz, Lensa Idossa, Steven Joffe, Naynesh Kamani, Roberta King, Aleksandr Lazaryan, Lawrence Morris, Mary M Horowitz, Navneet S Majhail
PURPOSE: Due to the complexity of hematopoietic cell transplant trial treatments, informed consent forms are often long and difficult to read. We evaluated a two-column easy-to-read informed consent (ETRIC) form that incorporates elements of health literacy and readability in participants and centers participating in Blood and Marrow Transplant Clinical Trials Network (BMT CTN) clinical trials. METHODS: In a randomized study, 198 adult patients from 25 centers potentially eligible to participate in four BMT CTN interventional trials were randomized to ETRIC or standard consent form for that trial...
April 18, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29679747/age-hiv-status-and-research-context-determined-attrition-in-a-longitudinal-cohort-in-nigeria
#2
Eileen O Dareng, Yinka Olaniyan, Sally N Adebamowo, Olabimpe R Eseyin, Michael K Odutola, Elonna M Obiefuna, Richard A Offiong, Paul P Pharoah, Clement A Adebamowo
OBJECTIVE: We explored determinants of attrition a longitudinal cohort study in Nigeria. STUDY DESIGN AND SETTING: We enroled 1,020 women into a prospective study. Of these, 973 were eligible to return for follow-up. We investigated the determinants of attrition among eligible women using a sequential mixed methods design. We used logistic regression models to compare the baseline characteristics of responders and non-responders. At the end of the parent study, we conducted 4 focus group discussions and 8 key informant interviews with non-responders RESULTS: Of the 973 women included in the quantitative analysis, 26% were non-responders...
April 18, 2018: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/29679493/ppars-and-pain
#3
REVIEW
Bright N Okine, Jessica C Gaspar, David P Finn
Chronic pain is a common cause of disability worldwide and remains a global health and socioeconomic challenge. Current analgesics are either ineffective in a significant proportion of patients with chronic pain, or associated with significant adverse side effects. The peroxisome proliferator-activated receptors (PPARs), a family of nuclear hormone transcription factors, have emerged as important modulators of pain in preclinical studies and therefore a potential therapeutic target for the treatment of pain...
April 21, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29679491/ionizing-radiation-induced-acoustics-for-radiotherapy-and-diagnostic-radiology-applications
#4
Susannah Hickling, Liangzhong Xiang, Kevin C Jones, Katia Parodi, Walter Assmann, Stephen Avery, Maritza Hobson, Issam El Naqa
Acoustic waves are induced via the thermoacoustic effect in objects exposed to a pulsed beam of ionizing radiation. This phenomenon has interesting potential applications in both radiotherapy dosimetry and treatment guidance as well as low dose radiological imaging. After initial work in the field in the 1980s and early 1990s, little research was done until 2013 when interest was rejuvenated, spurred on by technological advances in ultrasound transducers and the increasing complexity of radiotherapy delivery systems...
April 21, 2018: Medical Physics
https://www.readbyqxmd.com/read/29679306/regenerative-medicine-strategies-in-biomedical-implants
#5
REVIEW
Divya Rani Bijukumar, Clay McGeehan, Mathew T Mathew
PURPOSE OF REVIEW: Recently, significant progress has been made in the research related to regenerative medicine. At the same time, biomedical implants in orthopedics and dentistry are facing many challenges and posing clinical concerns. The purpose of this chapter is to provide an overview of the clinical applications of current regenerative strategies to the fields of dentistry and orthopedic surgery. The main research question in this review is: What are the major advancement strategies in regenerative medicine that can be used for implant research? RECENT FINDINGS: The implant surfaces can be modified through patient-specific stem cells and plasma coatings, which may provide methods to improve osseointegration and sustainability of the implant...
April 20, 2018: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/29678927/digital-technologies-for-the-assessment-of-cognition-a-clinical-review
#6
REVIEW
Amy Chinner, Jasmine Blane, Claire Lancaster, Chris Hinds, Ivan Koychev
Dementia is the most widespread form of neurodegenerative disorder and is associated with an immense societal and personal cost. Prevalence of this disorder is projected to triple worldwide by 2050 leading to an urgent need to make advances in the efficiency of both its care and therapy research. Digital technologies are a rapidly advancing field that provide a previously unavailable opportunity to alleviate challenges faced by clinicians and researchers working in this area. This clinical review aimed to summarise currently available evidence on digital technologies that can be used to monitor cognition...
April 20, 2018: Evidence-based Mental Health
https://www.readbyqxmd.com/read/29678086/implementing-systems-medicine-a-medical-informatics-perspective
#7
Matthias Ganzinger, Matthias Gietzelt, Christian Karmen, Blanca Flores, Petra Knaup
Systems medicine is a paradigm for translating in silico methods developed for modelling biological systems into the field of medicine. Such approaches rely on the integration of as many data sources as possible, both in the dimension of disease knowledge and patient data. This is a challenging task that can only be implemented in clinical routine with the help of suitable information technology from the field of Medical Informatics. For the research project "Clinically-applicable, omics-based assessment of survival, side effects, and targets in multiple myeloma" (CLIOMMICS) we developed a prototypical systems medicine application system...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29677992/biomedical-informatics-how-to-choose-the-best-tool-for-each-task
#8
Fábio Maia, Luís Bastião Silva, José Luís Oliveira
The ever-increasing number of bioinformatics software tools that are publicly available, is leading to greater expectations about its regular use in clinical practice. However, from the end-users' perspective, they face many time the challenge of choosing the right tool for each task, from a panoply of solutions that have been developed over the years. In this paper, we propose a benchmarking methodology, based on a set of performance indicators, which can be used to identify the best methods and tools for each particular use case, both in research as in clinical practice...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29677972/reflection-on-mobile-applications-for-blood-pressure-management-a-systematic-review-on-potential-effects-and-initiatives
#9
Reyhaneh Mohammadi, Movahhedeh Ayatolahi Tafti, Soodabeh Hoveidamanesh, Reza Ghanavati, Omid Pournik
INTRODUCTION: Ischemic heart disease and stroke have been considered as the first global leading cause of death in last decades [1]. Blood pressure (BP) management is one of the easiest ways suggested for preventing and controlling cardiovascular diseases before the patient develops complications and death-following outcomes. Appearance of technology advancements in the health system has motivated researchers and health providers to study its different aspects and applications in order to improve disease prevention and management...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29676689/intravenous-acetaminophen-for-postoperative-supratentorial-craniotomy-pain-a-prospective-randomized-double-blinded-placebo-controlled-trial
#10
Walavan Sivakumar, Michael Jensen, Julie Martinez, Michael Tanana, Nancy Duncan, Robert Hoesch, Jay K Riva-Cambrin, Craig Kilburg, Safdar Ansari, Paul A House
OBJECTIVE Acute pain control after cranial surgery is challenging. Prior research has shown that patients experience inadequate pain control post-craniotomy. The use of oral medications is sometimes delayed because of postoperative nausea, and the use of narcotics can impair the evaluation of brain function and thus are used judiciously. Few nonnarcotic intravenous (IV) analgesics exist. The authors present the results of the first prospective study evaluating the use of IV acetaminophen in patients after elective craniotomy...
April 20, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29675992/genetic-counselors-as-social-and-behavioral-scientists-in-the-era-of-precision-medicine
#11
Barbara B Biesecker
In the era of precision medicine, translating genomics into clinical care will involve answering key questions in social and behavioral research. The scope of this research addresses assessing how clients perceive and use genomic information, and how effectively genetic counseling is meeting clients' needs. Outcomes are central to enhancing practice effectiveness, improving patient outcomes, and informing cost effective services to address workforce challenges. While genetic counseling is generally thought of as a clinical practice, genetic counselors contribute to research in several ways...
March 2018: American Journal of Medical Genetics. Part C, Seminars in Medical Genetics
https://www.readbyqxmd.com/read/29675508/are-trabecular-metal-cones-a-valid-option-to-treat-metaphyseal-bone-defects-in-complex-primary-and-revision-knee-arthroplasty
#12
REVIEW
Tommaso Bonanzinga, Thorsten Gehrke, Akos Zahar, Stefano Zaffagnini, Maurilio Marcacci, Carl Haasper
Purpose  Metaphyseal bone defects are a challenge in complex primary and revision total knee arthroplasty (TKA). Recently, several studies have been published with promising results about the use of Trabecular Metal (TM) cones to address bone defects. The aim of this study is to review the literature to assess the efficacy of TM cones to address metaphyseal bone loss. Methods  A comprehensive search was performed on PubMed, Medline, CINAHL, Cochrane, Embase, and Google Scholar databases using various combinations of the following keywords: "metaphyseal," "cones," "tantalum," "knee," and "revision...
March 2018: Joints
https://www.readbyqxmd.com/read/29674514/pharmacokinetic-studies-in-children-recommendations-for-practice-and-research
#13
REVIEW
Charlotte I S Barker, Joseph F Standing, Lauren E Kelly, Lauren Hanly Faught, Allison C Needham, Michael J Rieder, Saskia N de Wildt, Martin Offringa
Optimising the dosing of medicines for neonates and children remains a challenge. The importance of pharmacokinetic (PK) and pharmacodynamic (PD) research is recognised both in medicines regulation and paediatric clinical pharmacology, yet there remain barriers to undertaking high-quality PK and PD studies. While these studies are essential in understanding the dose-concentration-effect relationship and should underpin dosing recommendations, this review examines how challenges affecting the design and conduct of paediatric pharmacological studies can be overcome using targeted pharmacometric strategies...
April 19, 2018: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29674441/promoting-accrual-of-older-patients-with-cancer-to-clinical-trials-an-alliance-for-clinical-trials-in-oncology-member-survey-a171602
#14
Rachel A Freedman, Travis J Dockter, Jacqueline M Lafky, Arti Hurria, Hyman J Muss, Harvey J Cohen, Aminah Jatoi, M Margaret Kemeny, Kathryn J Ruddy
BACKGROUND: There are multiple known individual- and practice-level barriers to enrollment of older patients with cancer to clinical trials, but little is known about how the clinical research workforce feels about potential higher-level strategy changes aimed to promote increased enrollment of older patients. SUBJECTS, MATERIALS, AND METHODS: We invited all 11,351 Alliance for Clinical Trials in Oncology ("Alliance") members to participate in an anonymous, web-based survey to examine awareness of current accrual patterns for older patients to clinical trials, to ascertain consensus on how to tackle enrollment challenges, and to provide the impetus for high-level changes to improve clinical trial accrual of older patients with cancer...
April 19, 2018: Oncologist
https://www.readbyqxmd.com/read/29674311/-wish-you-were-here-examining-characteristics-outcomes-and-statistical-solutions-for-missing-cases-in-web-based-psychotherapeutic-trials
#15
Eyal Karin, Blake F Dear, Gillian Z Heller, Monique F Crane, Nickolai Titov
BACKGROUND: Missing cases following treatment are common in Web-based psychotherapy trials. Without the ability to directly measure and evaluate the outcomes for missing cases, the ability to measure and evaluate the effects of treatment is challenging. Although common, little is known about the characteristics of Web-based psychotherapy participants who present as missing cases, their likely clinical outcomes, or the suitability of different statistical assumptions that can characterize missing cases...
April 19, 2018: JMIR Mental Health
https://www.readbyqxmd.com/read/29673604/concurrence-of-big-data-analytics-and-healthcare-a-systematic-review
#16
REVIEW
Nishita Mehta, Anil Pandit
BACKGROUND: The application of Big Data analytics in healthcare has immense potential for improving the quality of care, reducing waste and error, and reducing the cost of care. PURPOSE: This systematic review of literature aims to determine the scope of Big Data analytics in healthcare including its applications and challenges in its adoption in healthcare. It also intends to identify the strategies to overcome the challenges. DATA SOURCES: A systematic search of the articles was carried out on five major scientific databases: ScienceDirect, PubMed, Emerald, IEEE Xplore and Taylor & Francis...
June 2018: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29673531/using-positron-emission-tomography-in-revealing-the-mystery-of-general-anesthesia-study-design-challenges-and-opportunities
#17
Harry Scheinin, Emilee C Alkire, Annalotta Scheinin, Michael T Alkire, Oskari Kantonen, Jaakko Långsjö
Functional neuroimaging with positron emission tomography (PET) is one of the cornerstones for studying the central nervous system effects of general anesthetics and anesthesia mechanisms. General anesthesia offers a unique and safe way to directly manipulate consciousness, and can thus be used as a powerful research tool to study the neurobiology of human consciousness. In this chapter, we will address the possibilities of PET imaging in revealing the mysteries of general anesthesia and anesthetic induced unconsciousness and summarize some of the recent advancements in the field...
2018: Methods in Enzymology
https://www.readbyqxmd.com/read/29672914/revisiting-the-nih-taskforce-on-the-research-needs-of-eosinophil-associated-diseases-re-tread
#18
REVIEW
Paneez Khoury, Praveen Akuthota, Steven J Ackerman, Joseph R Arron, Bruce S Bochner, Margaret H Collins, Jean-Emmanuel Kahn, Patricia C Fulkerson, Gerald J Gleich, Rashmi Gopal-Srivastava, Elizabeth A Jacobsen, Kristen M Leiferman, Levi-Schaffer Francesca, Sameer K Mathur, Michael Minnicozzi, Calman Prussin, Marc E Rothenberg, Florence Roufosse, Kathleen Sable, Dagmar Simon, Hans-Uwe Simon, Lisa A Spencer, Jonathan Steinfeld, Andrew J Wardlaw, Michael E Wechsler, Peter F Weller, Amy D Klion
BACKGROUND: Eosinophil-associated diseases (EADs) are rare, heterogeneous disorders characterized by the presence of eosinophils in tissues and/or peripheral blood resulting in immunopathology. The heterogeneity of tissue involvement, lack of sufficient animal models, technical challenges in working with eosinophils, and lack of standardized histopathologic approaches have hampered progress in basic research. Additionally, clinical trials and drug development for rare EADs are limited by the lack of primary and surrogate endpoints, biomarkers, and validated patient-reported outcomes...
April 19, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29672878/quality-of-life-in-patients-with-adrenal-disease-a-systematic-review
#19
Winnie Ho, Maralyn Druce
BACKGROUND: Evaluating the patient with adrenal disease is challenging due to the lack of precise clinical and biochemical parameters for disease control. Quality of Life (QOL) evaluation aims to measure the patient's subjective experience. OBJECTIVE: to describe how QOL is defined and measured in adrenal disease, critically appraise the use of QOL tools in published literature, discuss the implications of these findings and provide direction for further research in this field...
April 19, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29672191/knowledge-and-beliefs-about-oncofertility-and-associations-with-quality-of-life-among-adolescent-and-young-adult-survivors-of-pediatric-cancer
#20
Andrea C Johnson, Darren Mays, Kathryn Rehberg, Aziza Shad, Kenneth P Tercyak
PURPOSE: Adolescent and young adult (AYA) cancer survivors experience fertility and childrearing challenges in adulthood, but there is limited evidence on awareness, beliefs, and concerns about oncofertility in this population, needs for supportive resources, and associations with quality of life (QoL). METHODS: Participants were 69 AYAs aged 12-25 who were diagnosed with cancer at age 18 years or younger and ≥1 year cancer free, recruited from childhood cancer clinical records and support organizations...
April 19, 2018: Journal of Adolescent and Young Adult Oncology
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