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https://www.readbyqxmd.com/read/29045851/trends-in-pelvic-inflammatory-disease-emergency-department-visits-united-states-2006-2013
#1
Kristen Kreisel, Elaine W Flagg, Elizabeth Torrone
BACKGROUND: Pelvic inflammatory disease is a female genital tract disorder with severe reproductive sequelae. Due to difficulties in diagnosing pelvic inflammatory disease, it is not a reportable condition in many states. Females seeking care in emergency departments are a sentinel population for pelvic inflammatory disease surveillance. OBJECTIVE: To determine trends in diagnoses of acute pelvic inflammatory disease in a nationally representative sample of emergency departments...
October 15, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29045749/immune-checkpoint-inhibitor-related-myocarditis
#2
Kazuko Tajiri, Kazutaka Aonuma, Ikuo Sekine
Immune checkpoint inhibitors have demonstrated significant clinical benefit in many cancers. The clinical benefit afforded by these treatments can be accompanied by a unique and distinct spectrum of adverse events. Recently, several fatal cases of immune checkpoint inhibitor-related myocarditis were reported. Although its frequency is comparatively lower than that of other immune-related adverse events, myocarditis can lead to circulatory collapse and lethal ventricular arrhythmia. Immune checkpoints, cytotoxic T-lymphocyte antigen 4 (CTLA-4) and programmed cell death protein 1 (PD-1), play important roles in establishing peripheral tolerance to the heart...
October 17, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29045273/oneflorida-clinical-research-consortium-linking-a-clinical-and-translational-science-institute-with-a-community-based-distributive-medical-education-model
#3
Elizabeth Shenkman, Myra Hurt, William Hogan, Olveen Carrasquillo, Steven Smith, Andrew Brickman, David Nelson
PROBLEM: Developing a national pragmatic clinical trial infrastructure is central to understanding the effectiveness of interventions applied under usual conditions and where people receive health care. To address this challenge, three Florida universities- the University of Florida Clinical and Translational Science Institute, Florida State University (with its community-based distributive medical education model), and the University of Miami-created (2010-2013) a statewide consortium, the OneFlorida Clinical Research Consortium, to support the conduct of pragmatic clinical trials and provide mentored research experiences for medical and graduate students in real-world practice settings...
October 17, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29044850/mesenchymal-stem-cells-therapy-a-promising-cell-based-therapy-for-treatment-of-myocardial-infraction
#4
REVIEW
Ayman El Sayed Shafei, Mahmoud Ahmed Ali, Hazem G Ghanem, Ahmed I Shehata, Ahmed A Abdelgawad, Hossam R Handal, Kareem A Talaat, Ahmed E Ashaal, Amal S El-Shal
AIM: For decades, mesenchymal stem (MSCs) cells had been used for cardiovascular diseases as regenerative therapy. This review is an attempt to summarize the types of MSCs involved in MI therapy, its possible mechanisms effects especially paracrine one in MI focusing on the studies (human and animal) conducted in the last 10 years. DISCUSSION: Recently, reports showed that MSC therapy could have infarct-limiting effects after myocardial infarction (MI) in both experimental and clinical trials...
October 16, 2017: Journal of Gene Medicine
https://www.readbyqxmd.com/read/29044471/analysis-and-annotation-of-whole-genome-or-whole-exome-sequencing-derived-variants-for-clinical-diagnosis
#5
Elizabeth A Worthey
Over the last 10 years, next-generation sequencing (NGS) has transformed genomic research through substantial advances in technology and reduction in the cost of sequencing, and also in the systems required for analysis of these large volumes of data. This technology is now being used as a standard molecular diagnostic test in some clinical settings. The advances in sequencing have come so rapidly that the major bottleneck in identification of causal variants is no longer the sequencing or analysis (given access to appropriate tools), but rather clinical interpretation...
October 18, 2017: Current Protocols in Human Genetics
https://www.readbyqxmd.com/read/29044180/evaluating-phenotype-driven-approaches-for-genetic-diagnoses-from-exomes-in-a-clinical-setting
#6
Reuben J Pengelly, Thahmina Alom, Zijian Zhang, David Hunt, Sarah Ennis, Andrew Collins
Next generation sequencing is transforming clinical medicine and genome research, providing a powerful route to establishing molecular diagnoses for genetic conditions; however, challenges remain given the volume and complexity of genetic variation. A number of methods integrate patient phenotype and genotypic data to prioritise variants as potentially causal. Some methods have a clinical focus while others are more research-oriented. With clinical applications in mind we compare results from alternative methods using 21 exomes for which the disease causal variant has been previously established through traditional clinical evaluation...
October 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29043230/advances-in-the-treatment-of-newly-diagnosed-primary-central-nervous-system-lymphomas
#7
REVIEW
Liren Qian, Ciprian Tomuleasa, Ioan-Alexandru Florian, Jianliang Shen, Ioan-Stefan Florian, Mihnea Zdrenghea, Delia Dima
Primary central nervous system lymphoma (PCNSL) is a type of highly invasive non-Hodgkin lymphoma. With a growing number of organ transplantation and immunosuppressant therapy, the incidence of PCNSL has been growing rapidly in recent years, which is attributed to the increased incidence of HIV/AIDS, a prominent risk factor for developing PCNSL. The rising rate of PCNSL incidence is the highest among the intracranial tumors. In the past 20 years, dozens of clinical trials related to PCNSL have been registered, but adequate therapeutics are still challenging...
September 2017: Blood Research
https://www.readbyqxmd.com/read/29042825/antithrombotics-in-trauma-management-strategies-in-the-older-patients
#8
REVIEW
Henna Wong, Nicola Lovett, Nicola Curry, Ku Shah, Simon J Stanworth
The ageing population has resulted in a change in the demographics of trauma, and older adult trauma now accounts for a growing number of trauma admissions. The management of older adult trauma can be particularly challenging, and exhibits differences to that of the younger age groups affected by trauma. Frailty syndromes are closely related with falls, which are the leading cause of major trauma in older adults. Comorbid disease and antithrombotic use are more common in the older population. Physiological changes that occur with ageing can alter the expected clinical presentation of older persons after injury and their susceptibility to injury...
2017: Journal of Blood Medicine
https://www.readbyqxmd.com/read/29042374/-what-does-that-mean-a-qualitative-exploration-of-the-primary-and-secondary-clinical-care-experiences-of-young-people-with-continence-problems-in-the-uk
#9
Katie Whale, Helen Cramer, Anne Wright, Caroline Sanders, Carol Joinson
OBJECTIVES: To explore the clinical care experiences of young people with continence problems. DESIGN: In-depth semistructured qualitative interviews were conducted by Skype and telephone, with the addition of art-based participatory research techniques. Transcripts were analysed using inductive thematic analysis. SETTING: Primary and secondary care in the UK. PARTICIPANTS: We interviewed 20 participants (9 females, 11 males) aged 11-20 years...
October 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/29042245/a-natural-language-processing-challenge-for-clinical-records-research-domains-criteria-rdoc-for-psychiatry
#10
EDITORIAL
Ozlem Uzuner, Amber Stubbs, Michele Filannino
No abstract text is available yet for this article.
October 14, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/29042131/expanding-our-perspectives-on-research-in-musculoskeletal-science-and-practice
#11
Roger Kerry
INTRODUCTION: The quantity and quality of scientific research within physiotherapy has unquestionably grown and matured over the last few decades, especially since the "formal" onset of evidence-based physiotherapy in the 1990s. The urgent need to evaluate our practice for effectiveness and efficiency has been responded to with thought and respect to both scientific integrity and shop-floor clinical needs. However, after thirty years or more of a professionally-governed and strategic approach to research activity, it is now timely to reflect, review, and consider the next chapter in the relationship between scientific research and clinical practice...
October 12, 2017: Musculoskeletal Science & Practice
https://www.readbyqxmd.com/read/29041950/convenience-without-disclosure-a-formative-research-study-of-a-proposed-integrated-methadone-and-antiretroviral-therapy-service-delivery-model-in-dar-es-salaam-tanzania
#12
Alexis Cooke, Haneefa Saleem, Dorothy Mushi, Jessie Mbwambo, Saria Hassan, Barrot H Lambdin
BACKGROUND: Though timely initiation of antiretroviral therapy (ART) is a vital component of effective HIV prevention, care and treatment, people who inject drugs are less likely to receive ART than their non-drug using counterparts. In an effort to increase access to ART for people who inject drugs, we examined perceived benefits, challenges, and recommendations for implementing an integrated methadone and ART service delivery model at an opioid treatment program (OTP) clinic in Dar es Salaam, Tanzania...
October 18, 2017: Addiction Science & Clinical Practice
https://www.readbyqxmd.com/read/29041866/-progressive-ms-macro-views-the-need-for-novel-clinical-trial-paradigms-to-enable-drug-development-for-progressive-ms
#13
P Zaratin, G Comi, D Leppert
This article outlines the principal challenges to establish a standard phase-2 approach for progressive multiple sclerosis (PMS) and presents referring strategies to accelerate the registration process via a guidance approved by regulatory agencies. Accordingly, the contribution of 'big datasets' for a better understanding of the natural history of primary-progressive multiple sclerosis (PPMS) and secondary-progressive multiple sclerosis (SPMS) and of their prognostic factors and the value of novel biomarkers are discussed...
October 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29041821/gender-matters-in-the-transition-to-employment-for-young-adults-with-physical-disabilities
#14
Sally Lindsay, Elaine Cagliostro, Mikhaela Albarico, Neda Mortaji, Dilakshan Srikanthan
PURPOSE: The purpose of this study was to explore the role of gender in the transition to employment for young adults with physical disabilities. METHODS: This study drew on in-depth interviews with a purposive sample of 33 participants (23 youth and 10 clinicians). The youth in our sample included 13 females (mean age 22.9) and 10 males (mean age 21.3) who had various types of physical disabilities. The person-environment-occupation (PEO) model informed our analysis...
October 17, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29040644/displaying-and-analyzing-quality-improvement-data
#15
Patrick W Brady, Michael J Tchou, Lilliam Ambroggio, Amanda C Schondelmeyer, Erin E Shaughnessy
In this second article in the quality improvement (QI) methods series, we discuss how data are best displayed and analyzed in QI projects while focusing on some similarities with and differences from traditional clinical research. We demonstrate why displaying data over time on a run or control chart is superior to using pre-post analysis for QI studies. We introduce several types of statistical process control charts for data commonly collected during QI programs and provide guidance on how to use the proper chart...
October 5, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/29040639/the-medical-science-dmz-a-network-design-pattern-for-data-intensive-medical-science
#16
Sean Peisert, Eli Dart, William Barnett, Edward Balas, James Cuff, Robert L Grossman, Ari Berman, Anurag Shankar, Brian Tierney
Objective: We describe a detailed solution for maintaining high-capacity, data-intensive network flows (eg, 10, 40, 100 Gbps+) in a scientific, medical context while still adhering to security and privacy laws and regulations. Materials and Methods: High-end networking, packet-filter firewalls, network intrusion-detection systems. Results: We describe a "Medical Science DMZ" concept as an option for secure, high-volume transport of large, sensitive datasets between research institutions over national research networks, and give 3 detailed descriptions of implemented Medical Science DMZs...
October 6, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29040589/corifollitropin-alfa-followed-by-highly-purified-hmg-versus-recombinant-fsh-in-young-poor-ovarian-responders-a-multicentre-randomized-controlled-clinical-trial
#17
Panagiotis Drakopoulos, Thi Ngoc Lan Vuong, Ngoc Anh Vu Ho, Alberto Vaiarelli, Manh Tuong Ho, Christophe Blockeel, Michel Camus, Anh Tuan Lam, Arne van de Vijver, Peter Humaidan, Herman Tournaye, Nikolaos P Polyzos
STUDY QUESTION: Does administration of corifollitropin alfa followed by highly purified (hp) HMG result in higher ongoing pregnancy rates compared with daily recombinant FSH (rFSH) in young poor responders? SUMMARY ANSWER: Corifollitropin alfa followed by hp-HMG does not increase ongoing pregnancy rates compared with rFSH in young poor responders, although more supernumerary cryopreserved embryos were obtained with corifollitropin alfa and hp-HMG. WHAT IS KNOWN ALREADY: Poor ovarian response remains one of the main therapeutic challenges in women undergoing ovarian stimulation, given that very low live birth rates of 6% have been reported in this particular group of infertile patients...
September 23, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29040358/tissue-expansion-using-hyaluronic-acid-filler-for-single-stage-ear-reconstruction-a-novel-concept-for-difficult-areas
#18
Amir Inbal, Benjamin T Lemelman, Eran Millet, Andrew Greensmith
Background: Auricular reconstruction is one of the most challenging procedures in plastic surgery. An adequate skin envelope is essential for cartilage framework coverage, yet few good options exist without additional surgery. We propose a novel method for minimally invasive tissue expansion, using hyaluronic acid (HA) filler to allow for single-stage ear reconstruction. Objectives: To introduce the novel concept of HA filler for tissue expansion in ear reconstruction, and as an alternative to traditional expansion techniques...
July 20, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29039978/preimplantation-genetic-testing-current-challenges-and-future-prospects
#19
Anver Kuliev, Svetlana Rechitsky
Preimplantation genetic testing (PGT) is now a widely applied procedure in genetic practices and ART, with more than one third of ART Centers in US already utilizing PGT technology. Its indications have also been significantly extended to include common late-onset disorders and non-genetic conditions, such as testing for HLA match. Areas covered: This is a critical review of the developments in PGT, with emphasis on their outstanding limitations and directions for the future research and practice in the area of PGT...
October 17, 2017: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/29039742/disease-related-detection-with-electrochemical-biosensors-a-review
#20
REVIEW
Ying Huang, Jin Xu, Junjie Liu, Xiangyang Wang, Bin Chen
Rapid diagnosis of diseases at their initial stage is critical for effective clinical outcomes and promotes general public health. Classical in vitro diagnostics require centralized laboratories, tedious work and large, expensive devices. In recent years, numerous electrochemical biosensors have been developed and proposed for detection of various diseases based on specific biomarkers taking advantage of their features, including sensitivity, selectivity, low cost and rapid response. This article reviews research trends in disease-related detection with electrochemical biosensors...
October 17, 2017: Sensors
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