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toxoplasmosis ocular intravitreal

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https://www.readbyqxmd.com/read/27723657/recent-developments-in-the-diagnosis-and-treatment-of-ocular-toxoplasmosis
#1
Cem Ozgonul, Cagri Giray Besirli
Ocular toxoplasmosis, a chorioretinal infection with Toxoplasma gondii, is the most common etiology of posterior uveitis in many countries. Accurate diagnosis depends heavily on the characteristic clinical features of this disease, but atypical presentations, especially in immunocompromised patients, may create diagnostic challenges and lead to misdiagnosis and inappropriate treatment. Molecular biology techniques to diagnose ocular toxoplasmosis have been available for many years and are now accessible as standard laboratory tests in many countries...
2017: Ophthalmic Research
https://www.readbyqxmd.com/read/27463633/dress-syndrome-in-ophthalmic-patients
#2
Jacqueline Martins de Sousa, Heloisa Nascimento, Rubens Belfort
Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rare and potentially fatal adverse drug reaction associated with skin rash, fever, eosinophilia, and multiple organ injury. A number of pharmacological agents are known to cause DRESS syndrome such as allopurinol, anticonvulsants, vancomycin, trimethoprime-sulfamethoxazole, and pyrimethamine-sulfadiazine. Here, we describe two patients who developed DRESS syndrome during ocular treatment. The first case was being treated for late postoperative endophthalmitis with topical antibiotics, intravenous cephalothin, meropenem, and intravitreal injection of vancomycin and ceftazidime before symptoms developed...
May 2016: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/26773166/tgf-%C3%AE-1-levels-and-intraocular-tissue-alterations-in-mice-infected-with-a-virulent-type-i-rh-toxoplasma-gondii-strain
#3
Jamshaid Iqbal, Mohammad Ahmed Al-Awadhi, Raj Gopal Raghupathy
Toxoplasmosis is generally self-limiting in healthy adults but it may cause toxoplasmic retinochoroiditis in cases of congenital infection leading to blindness. The importance of host genetics in determining disease severity in ocular toxoplasmosis has been shown in different inbred mouse strains using low-virulence toxoplasma strain. In this study, we studied intraocular immune response and tissue alterations in the genetically resistant BALB/c and susceptible MF1 mice infected with a virulent type I RH Toxoplasma gondii strain by intravitreal route...
March 2016: Experimental Parasitology
https://www.readbyqxmd.com/read/26676856/anti-toxoplasma-activity-and-impact-evaluation-of-lyophilization-hot-molding-process-and-gamma-irradiation-techniques-on-clh-plga-intravitreal-implants
#4
Gabriella M Fernandes-Cunha, Cíntia M F Rezende, Wagner N Mussel, Gisele R da Silva, Elionai C de L Gomes, Maria I Yoshida, Sílvia L Fialho, Alfredo M Goes, Dawison A Gomes, Ricardo W de Almeida Vitor, Armando Silva-Cunha
Intraocular delivery systems have been developed to treat many eye diseases, especially those affecting the posterior segment of the eye. However, ocular toxoplasmosis, the leading cause of infectious posterior uveitis in the world, still lacks an effective treatment. Therefore, our group developed an intravitreal polymeric implant to release clindamycin, a potent anti-Toxoplasma antibiotic. In this work, we used different techniques such as differential scanning calorimetry, thermogravimetry, X-ray diffraction, scanning electron microscopy, and fourier-transform infrared spectroscopy to investigate drug/polymer properties while manufacturing the delivery system...
January 2016: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/26405767/volume-rendering-of-optical-coherence-tomography-angiography-reveals-extensive-retinal-vascular-contributions-to-neovascularization-in-ocular-toxoplasmosis
#5
https://www.readbyqxmd.com/read/26322295/thermoanalytical-characterization-of-clindamycin-loaded-intravitreal-implants-prepared-by-hot-melt-extrusion
#6
Lana Tamaddon, Seyed Abolfazl Mostafavi, Reza Karkhane, Mohammad Riazi-Esfahani, Farid Abedin Dorkoosh, Morteza Rafiee-Tehrani
BACKGROUND: The aim of the present study was to evaluate a non-destructive fabrication method in for the development of sustained-release poly (L, D-lactic acid)-based biodegradable clindamycin phosphate implants for the treatment of ocular toxoplasmosis. MATERIALS AND METHODS: The rod-shaped intravitreal implants with an average length of 5 mm and a diameter of 0.4 mm were evaluated for their physicochemical parameters. Scanning electron microscopy (SEM), differential scanning calorimetry (DSC), Fourier-transform infrared (FTIR), and nuclear magnetic resonance (1H NMR) studies were employed in order to study the characteristics of these formulations...
2015: Advanced Biomedical Research
https://www.readbyqxmd.com/read/26185543/coexisting-choroidal-neovascularization-and-active-retinochoroiditis-an-uncommon-presentation-of-ocular-toxoplasmosis
#7
Sharat Hegde, Nidhi Relhan, Avinash Pathengay, Abhishek Bawdekar, Himadri Choudhury, Animesh Jindal, Harry W Flynn
BACKGROUND: Choroidal neovascularization during the active stage of Toxoplasma retinochoroiditis is an uncommon clinical presentation. The authors retrospectively reviewed medical charts of patients with coexisting choroidal neovascular membrane and active Toxoplasma retinochoroiditis. FINDINGS: Three patients presented with coexisting choroidal neovascular membrane and active Toxoplasma retinochoroiditis. All lesions had adjacent subretinal hemorrhage. The diagnosis was confirmed based on clinical presentation, fundus fluorescein angiography (FFA), and optical coherence tomography (OCT) findings...
2015: Journal of Ophthalmic Inflammation and Infection
https://www.readbyqxmd.com/read/26010656/subretinal-fluid-in-eyes-with-active-ocular-toxoplasmosis-observed-using-spectral-domain-optical-coherence-tomography
#8
Yanling Ouyang, Fuqiang Li, Qing Shao, Florian M Heussen, Pearse A Keane, Nicole Stübiger, Srinivas R Sadda, Uwe Pleyer
PURPOSE: To describe the clinical finding of subretinal fluid (SRF) in the posterior pole by spectral domain optical coherence tomography (SD-OCT) in eyes with active ocular toxoplasmosis (OT). DESIGN: Retrospective case series. PARTICIPANTS: Thirty-nine eyes from 38 patients with active OT [corrected].. METHODS: Eyes with active OT which underwent SD-OCT were reviewed. SRFs in the posterior pole were further analyzed...
2015: PloS One
https://www.readbyqxmd.com/read/25763208/intravitreal-clindamycin-in-the-treatment-of-unresponsive-zone-one-toxoplasmic-chorioretinitis-a-case-report
#9
Seyedeh Maryam Hosseini, Mojtaba Abrishami, Mehran Mehdi Zadeh
INTRODUCTION: The current study aimed to report a case of toxoplasma chorioretinitis resistant to standard treatments that dramatically responded to intravitreal clindamycin injection. CASE PRESENTATION: A 23-year-old woman with the diagnosis of ocular toxoplasmosis in the left eye was initially treated by oral pyrimethamine, sulfadiazine, azithromycin and oral prednisolone. Since the treatment was unsuccessful intravitreal clindamycin (1 mg/ 0.1 mL) was injected...
November 2014: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/25754200/interleukin-6-driven-inflammatory-response-induces-retinal-pathology-in-a-model-of-ocular-toxoplasmosis-reactivation
#10
Élise Rochet, Julie Brunet, Marcela Sabou, Luc Marcellin, Tristan Bourcier, Ermanno Candolfi, Alexander W Pfaff
Ocular inflammation is one of the consequences of infection with the protozoan parasite Toxoplasma gondii. Even if lesions are self-healing in immunocompetent persons, they pose a lifetime risk of reactivation and are a serious threat to vision. As there are virtually no immunological data on reactivating ocular toxoplasmosis, we established a model of direct intravitreal injection of parasites in previously infected mice with a homologous type II strain. Two different mouse strains with variable ability to control retinal infection were studied in order to describe protective and deleterious reaction patterns...
May 2015: Infection and Immunity
https://www.readbyqxmd.com/read/25693767/il-33-st2-involves-the-immunopathology-of-ocular-toxoplasmosis-in-murine-model
#11
Xinxin Tong, Fangli Lu
Ocular toxoplasmosis (OT) is the major cause of infective uveitis. Since the eye is a special organ protected by immune privilege, its immune response is different from general organs with Toxoplasma gondii infection. Here, we used Kunming outbred mice to establish OT by intravitreal injection of T. gondii RH strain tachyzoites, IL-33 expression in the eyes was localized by immunostaining, the levels of interleukin (IL)-33 and ST2 (IL-33 receptor) and T-helper (Th)1 and Th2-associated cytokines in the eye and cervical lymph nodes (CLNs) of infected mice were measured, and their correlations were analyzed...
May 2015: Parasitology Research
https://www.readbyqxmd.com/read/25559528/the-role-of-intravitreal-trimethoprim-sulfamethoxazole-in-the-treatment-of-toxoplasma-retinochoroiditis
#12
Himadri Choudhury, Animesh Jindal, Avinash Pathengay, Abhishek Bawdekar, Thomas Albini, Harry W Flynn
The authors evaluate the role of intravitreal trimethoprim/sulfamethoxazole in the treatment of toxoplasma retinochoroiditis (TRC) in four patients. Intravitreal injection of trimethoprim/sulfamethoxazole 1.28 mg/0.08 mL with dexamethasone 400 µg/0.1 mL was injected weekly or biweekly. After the initiation of treatment, a reduction in intraocular inflammation was observed clinically and on optical coherence tomography within 1 week. Three patients regained visual acuity of 20/20, and one patient improved to 20/40 with residual macular scarring...
January 2015: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/25459934/development-of-a-method-to-quantify-clindamycin-in-vitreous-humor-of-rabbits-eyes-by-uplc-ms-ms-application-to-a-comparative-pharmacokinetic-study-and-in-vivo-ocular-biocompatibility-evaluation
#13
COMPARATIVE STUDY
Gabriella M Fernandes-Cunha, Dayana Rubio Gouvea, Gustavo de Oliveira Fulgêncio, Cíntia M F Rezende, Gisele Rodrigues da Silva, Juliana M Bretas, Sílvia Ligório Fialho, Norberto Peporine Lopes, Armando Silva-Cunha
Ocular toxoplasmosis may result in uveitis in the posterior segment of the eye, leading to severe visual complications. Clindamycin-loaded poly(lactide-co-glycolide) (PLGA) implants could be applied to treat the ocular toxoplasmosis. In this study, the pharmacokinetic profiles of the drug administrated by PLGA implants and by intravitreal injections in rabbits' eyes were evaluated. The implant released the drug for 6 weeks while the drug administrated by intravitreal injections remained in the vitreous cavity for 2 weeks...
January 2015: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/25390432/successful-treatment-of-toxoplasmosis-associated-choroidal-neovascular-lesions-with-bevacizumab-and-antiparasitic-therapy
#14
Chun-Ju Lin, San-Ni Chen, Jiunn-Feng Hwang, Pei-Shin Hu
PURPOSE: To report the effects of oral trimethoprim/sulfamethoxazole and intravitreal bevacizumab injection in the treatment of ocular toxoplasmosis-associated choroidal neovascular lesions (CNV). METHODS: This was a noncomparative, nonrandomized, consecutive case series. All eyes with ocular toxoplasmosis-associated CNV received one intravitreal bevacizumab injection under the coverage of oral trimethoprim/sulfamethoxazole. The changes in best-corrected visual acuity were recorded...
2011: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/25378880/paediatric-choroidal-neovascular-membrane-secondary-to-toxoplasmosis-treated-successfully-with-anti-vascular-endothelial-growth-factor
#15
Gaurav Mathur, Amala Elizabeth George, Parveen Sen
The purpose of this report was to evaluate the role anti-VEGF in management of CNVM secondary to ocular toxoplasmosis. Young female diagnosed as a case of bilateral ocular toxoplasmosis presented with complaints of diminution of vision in the right eye. Fundus examination showed an active CNVM adjacent to toxoplasmosis scar. In view of active CNVM, patient was administered intravitreal ranibizumab. A total of 2 injections of intravitreal ranibizumab were given. Fundus showed a scarred CNVM adjacent to the toxoplasma scar with no clinical signs of activity...
September 2014: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/25197557/current-treatment-of-toxoplasma-retinochoroiditis-an-evidence-based-review
#16
REVIEW
Meredith Harrell, Petros E Carvounis
Objective. To perform an evidence-based review of treatments for Toxoplasma retinochoroiditis (TRC). Methods. A systematic literature search was performed using the PubMed database and the key phrase "ocular toxoplasmosis treatment" and the filter for "controlled clinical trial" and "randomized clinical trial" as well as OVID medline (1946 to May week 2 2014) using the keyword ''ocular toxoplasmosis". The included studies were used to evaluate the various treatment modalities of TRC. Results. The electronic search yielded a total of 974 publications of which 44 reported on the treatment of ocular toxoplasmosis...
2014: Journal of Ophthalmology
https://www.readbyqxmd.com/read/24204154/resolution-of-vitreomacular-traction-following-intravitreal-ranibizumab-in-cases-of-ocular-toxoplasmosis-with-choroidal-neovascularization
#17
Petros Petrou, Ilias Georgalas, Nikolaos Markomichelakis, Ioannis Vergados, Emanuela Gianakaki, Alexander Rouvas
PURPOSE: To present the occurrence of the resolution of vitreomacular traction following intravitreal ranibizumab in two patients with inflammatory choroidal neovascular (CNV) membrane with a background of ocular toxoplasmosis. METHODS: Interventional case report. RESULTS: A 21-year-old Caucasian woman and a 52-year-old Caucasian man both presented with vitreomacular traction with coexistent classic CNV membrane and a background of ocular toxoplasmosis...
2013: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/24175641/intravitreal-bevacizumab-for-treatment-of-choroidal-neovascularization-secondary-to-toxoplasmic-retinochoroiditis-a-case-series
#18
Farzan Kianersi, Afsaneh Naderi Beni, Zahra Naderi Beni, Heshmatollah Ghanbari
PURPOSE: To evaluate the efficacy and safety of intravitreal bevacizumab (Avastin) in treatment of choroidal neovascularization (CNV) secondary to toxoplasmic retinochoroiditis. DESIGN: Prospective case series. METHODS: Four patients affected by CNV secondary to inactive toxoplasmic retinochoroiditis received 1.25 mg intravitreal bevacizumab and were followed for at least six months. Patients underwent a full ophthalmic examination and fluorescein angiography (FA) and optical coherence tomography (OCT), revealing an active subfoveal CNV close to an old chorioretinal scar...
May 2015: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/23816507/antibiotics-for-human-toxoplasmosis-a-systematic-review-of-randomized-trials
#19
REVIEW
Senaka Rajapakse, Mitrakrishnan Chrishan Shivanthan, Nilakshi Samaranayake, Chaturaka Rodrigo, Sumadhya Deepika Fernando
The efficacy of different treatment regimens in clinical syndromes of toxoplasmosis were assessed by conducting a systematic review of published randomized clinical trials through extensive searches in MEDLINE, EMBASE, and SCOPUS with no date limits, as well as manual review of journals. Outcome measures varied depending on the clinical entity of toxoplasmosis. Risk of bias was evaluated and quality of evidence was graded. Fourteen randomized trials were included of which one was a non-comparative study. One well-designed trial showed that trimethoprim-sulphamethoxazole was more effective than placebo for clinical recovery of toxoplasmic lymphadenopathy in immunocompetent hosts...
June 2013: Pathogens and Global Health
https://www.readbyqxmd.com/read/23702129/the-local-immune-response-to-intraocular-toxoplasma-re-challenge-less-pathology-and-better-parasite-control-through-treg-th1-th2-induction
#20
Arnaud Sauer, Elise Rochet, Ibtissem Lahmar, Julie Brunet, Marcela Sabou, Tristan Bourcier, Ermanno Candolfi, Alexander W Pfaff
Ocular toxoplasmosis is a major cause of blindness world-wide. Ocular involvement is frequently seen following congenital infection. Many of these infections are quiescent but pose a life-time risk of reactivation. However, the physiopathology of ocular toxoplasmosis reactivation is largely unexplored. We previously developed a Swiss-Webster outbred mouse model for congenital toxoplasmosis by neonatal injection of Toxoplasma gondii cysts. We also used a mouse model of direct intraocular infection to show a deleterious local T helper 17 type response upon primary infection...
August 2013: International Journal for Parasitology
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