keyword
https://read.qxmd.com/read/38534941/cell-therapy-transplant-canada-cttc-consensus-based-guideline-2024-for-management-and-treatment-of-chronic-graft-versus-host-disease-and-future-directions-for-development
#1
Dennis Dong Hwan Kim, Gizelle Popradi, Kylie Lepic, Kristjan Paulson, David Allan, Ram Vasudevan Nampoothiri, Sylvie Lachance, Uday Deotare, Jennifer White, Mohamed Elemary, Kareem Jamani, Christina Fraga, Christopher Lemieux, Igor Novitzky-Basso, Arjun Datt Law, Rajat Kumar, Irwin Walker, Kirk R Schultz
This is a consensus-based Canadian guideline whose primary purpose is to standardize and facilitate the management of chronic graft-versus-host disease (cGvHD) across the country. Creating uniform healthcare guidance in Canada is a challenge for a number of reasons including the differences in healthcare authority structure, funding and access to healthcare resources between provinces and territories, as well as the geographic size. These differences can lead to variable and unequal access to effective therapies for GvHD...
March 8, 2024: Current Oncology
https://read.qxmd.com/read/38533650/experiences-of-patients-with-metachromatic-leukodystrophy-adrenoleukodystrophy-or-krabbe-disease-and-their-family-members-a-qualitative-systematic-review
#2
JOURNAL ARTICLE
Yuta Koto, Shingo Ueki, Miyae Yamakawa, Norio Sakai
OBJECTIVE: This review aimed to synthesize the experiences of patients with metachromatic leukodystrophy, adrenoleukodystrophy, or Krabbe disease and those of their families. INTRODUCTION: Leukodystrophies are metabolic diseases caused by genetic mutations. There are multiple forms of the disease, varying in age of onset and symptoms. The progression of leukodystrophies worsens central nervous system symptoms and significantly affects the lives of patients and their families...
March 28, 2024: JBI evidence synthesis
https://read.qxmd.com/read/38532458/a-phase-ii-study-of-belumosudil-for-chronic-graft-versus-host-disease-in-patients-who-failed-at-least-one-line-of-systemic-therapy-in-china
#3
JOURNAL ARTICLE
Ying Wang, Depei Wu, Xiang Zhang, Yuhua Li, Yanjie He, Qifa Liu, Li Xuan, Zhenyu Li, Kunming Qi, Yuqian Sun, Shunqing Wang, Wenjian Mo, Lei Gao, Ye Hua, Yu Wang, Ying Zhang
BACKGROUND: Chronic graft-versus-host disease (cGVHD) is an immune-related disorder that is the most common complication post-allogenic hematopoietic stem cell transplant. Corticosteroids with or without calcineurin inhibitors (CNIs) remain the mainstay of cGVHD treatment for first-line therapy. However, for many patients, cGVHD symptoms cannot be effectively managed and thus require second-line therapy. Currently, there is no approved treatment for second-line cGVHD treatment in China...
March 26, 2024: BMC Medicine
https://read.qxmd.com/read/38532070/generating-human-bone-marrow-organoids-for-disease-modeling-and-drug-discovery
#4
REVIEW
Aude-Anais Olijnik, Antonio Rodriguez-Romera, Zoë C Wong, Yuqi Shen, Jasmeet S Reyat, Natalie J Jooss, Julie Rayes, Bethan Psaila, Abdullah O Khan
The bone marrow supports and regulates hematopoiesis, responding to physiological requirements for blood cell production over ontogeny and during pathological challenges. Interactions between hematopoietic cells and niche components are challenging to study mechanistically in the human context, but are important to delineate in order to explore the pathobiology of blood and bone marrow disorders. Organoids are proving transformative in many research settings, but an accurate human bone marrow model incorporating multiple hematopoietic and stromal elements has been lacking...
March 26, 2024: Nature Protocols
https://read.qxmd.com/read/38530081/making-human-hematopoietic-stem-cells-without-transgenes
#5
Luis G Palma, Anna Bigas
Creating hematopoietic stem cells (HSCs) capable of multilineage engraft while possessing the ability to self-renew stands as a pivotal achievement within the field of regenerative medicine. However, achieving the generation of these cells without transgene expression or teratoma formation has not been fully accomplished. In a recent publication featured in Cell Stem Cell , Piau et al. document the production of functional HSCs derived from human-induced pluripotent stem cells (hiPSCs). They achieved this through a one-step differentiation protocol that notably does not require any transgene expression...
March 26, 2024: Cellular Reprogramming
https://read.qxmd.com/read/38529903/evaluation-of-the-impact-of-two-c5-genetic-variants-on-c5-eculizumab-complex-stability-at-the-molecular-level
#6
JOURNAL ARTICLE
Vanda P Peixoto, Cristina Prudêncio, Mónica Vieira, Sérgio F Sousa
Complement C5 is the target of the monoclonal antibody eculizumab, used in complement dysregulating disorders, like the rare disease Paroxysmal Nocturnal Hemoglobinuria (PNH). PNH is an acquired hematopoietic stem cell condition characterized by aberrant destruction of erythrocytes, chronic hemolytic anemia, and thromboembolism propensity. C5 is a protein component of the complement system which is part of the immune system of the body and plays a prominent role in the destruction of red blood cells, misidentifying them as a threat...
March 26, 2024: Journal of Biomolecular Structure & Dynamics
https://read.qxmd.com/read/38529407/direct-male-development-in-chromosomally-zz-zebrafish
#7
JOURNAL ARTICLE
Catherine A Wilson, Peter Batzel, John H Postlethwait
The genetics of sex determination varies across taxa, sometimes even within a species. Major domesticated strains of zebrafish ( Danio rerio ), including AB and TU, lack a strong genetic sex determining locus, but strains more recently derived from nature, like Nadia (NA), possess a ZZ male/ZW female chromosomal sex-determination system. AB fish pass through a juvenile ovary stage, forming oocytes that survive in fish that become females but die in fish that become males. To understand mechanisms of gonad development in NA zebrafish, we studied histology and single cell transcriptomics in developing ZZ and ZW fish...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38527833/-clinical-outcomes-of-allogeneic-hematopoietic-stem-cell-transplantation-for-chronic-myelomonocytic-leukemia
#8
JOURNAL ARTICLE
X H Zhang, J Y Zhou
Chronic myelomonocytic leukemia (CMML) is a clonal disease derived from bone marrow hematopoietic stem cells, with a poor prognosis. Allogeneic hematopoietic stem cell transplantation (allo- HSCT) is one of the curable methods for CMML. The outcome of patient transplantation is influenced by various factors such as disease characteristics and comorbidities. Based on the existing prognostic stratification system, screening suitable CMML patients for transplantation and early transplantation is beneficial for their long-term survival...
January 14, 2024: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://read.qxmd.com/read/38527292/kinome-expression-profiling-improves-risk-stratification-and-therapeutic-targeting-in-myelodysplastic-syndromes
#9
JOURNAL ARTICLE
Chi-Yuan Yao, Chien-Chin Lin, Yu-Hung Wang, Chein-Jun Kao, Xavier Cheng-Hong Tsai, Hsin-An Hou, Hwei-Fang Tien, Chia-Lang Hsu, Wen-Chien Chou
The human kinome, which comprises over five hundred kinases, plays a critical role in regulating numerous essential cellular functions. Although the dysregulation of kinases has been observed in various human cancers, the characterization and clinical implications of kinase expressions in myelodysplastic syndrome (MDS) have not been systematically investigated. In this study, we evaluated the kinome expression profiles of 341 adult patients with primary MDS and identified seven kinases (PTK7, KIT, MAST4, NTRK1, PAK6, CAMK1D, and PRKCZ) whose expression levels were highly predictive of compromised patient survival...
March 25, 2024: Blood Advances
https://read.qxmd.com/read/38525548/autologous-hematopoietic-stem-cells-transplantation-in-mogad
#10
JOURNAL ARTICLE
Sara Mariotto, Sara Carta
No abstract text is available yet for this article.
March 25, 2024: Multiple Sclerosis: Clinical and Laboratory Research
https://read.qxmd.com/read/38524139/progression-of-notch-signaling-regulation-of-b-cells-under-radiation-exposure
#11
REVIEW
Xin Shu, Jie Wang, Huihong Zeng, Lijian Shao
With the continuous development of nuclear technology, the radiation exposure caused by radiation therapy is a serious health hazard. It is of great significance to further develop effective radiation countermeasures. B cells easily succumb to irradiation exposure along with immunosuppressive response. The approach to ameliorate radiation-induced B cell damage is rarely studied, implying that the underlying mechanisms of B cell damage after exposure are eager to be revealed. Recent studies suggest that Notch signaling plays an important role in B cell-mediated immune response...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38523262/optimization-of-seeding-density-of-op9-cells-to-improve-hematopoietic-differentiation-efficiency
#12
JOURNAL ARTICLE
Xin-Xing Jiang, Meng-Yi Song, Qi Li, Yun-Jian Wei, Yuan-Hua Huang, Yan-Lin Ma
BACKGROUND: OP9 mouse stromal cell line has been widely used to induce differentiation of human embryonic stem cells (hESCs) into hematopoietic stem/progenitor cells (HSPCs). However, the whole co-culture procedure usually needs 14-18 days, including preparing OP9 cells at least 4 days. Therefore, the inefficient differentiation system is not appreciated. We aimed to optimize the culture conditions to improve differentiation efficiency. METHODS: In the experimental group, we set six different densities of OP9 cells and just cultured them for 24 h before co-culture, and in the control group, OP9 cells were cultured for 4 days to reach an overgrown state before co-culture...
March 25, 2024: BMC molecular and cell biology
https://read.qxmd.com/read/38523199/sustained-remission-after-cord-blood-transplantation-for-breast-cancer-with-lung-metastases-and-myelodysplastic-syndrome
#13
JOURNAL ARTICLE
Naokazu Nakamura, Nao Yamamoto, Tadakazu Kondo, Mayumi Matsumoto, Ryo Ikunari, Tomomi Sakai, Yasuhiro Tanaka, Hiroko Tsunemine, June Takeda, Junya Kanda, Yasuhito Nannya, Seishi Ogawa, Akifumi Takaori-Kondo, Nobuyoshi Arima
Allogenic hematopoietic stem cell transplantation (allo-HSCT) is not a standard therapy for solid cancer because of its high toxicity and insufficient evidence levels. However, the potential graft-versus-solid-tumor (GVT) effect of this therapy has been discussed. Many case reports have also described treatment effects of allo-HSCT in patients with hematologic malignancies and active solid tumors. A 38-year-old woman treated with fulvestrant and abemaciclib for recurrent breast cancer with multiple lung metastases was diagnosed with myelodysplastic syndrome (MDS) with increased blasts 2...
March 25, 2024: International Journal of Hematology
https://read.qxmd.com/read/38523042/consensus-of-the-brazilian-association-of-hematology-hemotherapy-and-cellular-therapy-on-patient-blood-management-definition-of-patient-blood-management
#14
JOURNAL ARTICLE
Juan Carlos Montano-Pedroso, Maria Cristina Martins de Almeida Macedo, Silvana Biagini, Glaciano Ribeiro, José Francisco Comenalli Marques Junior, Silvia Renata Cornélio Parolin Rizzo, Guilherme Rabello, Dante Mario Langhi Junior
Managing the patient's blood and hematopoietic system is like managing any of the other organs and organ systems during patient care. Specialists control the heart, kidneys, endocrine system, etc. and the patient's blood requires similar clinical treatment. The hematopoietic system and its circulatory products are fundamental for the healthy functioning of the human body. In simple terms, Patient Blood Management (PBM) is an organized, patient-centered approach in which the entire healthcare team coordinates efforts to improve outcomes by managing and preserving the patient's own blood...
March 8, 2024: Hematology, Transfusion and Cell Therapy
https://read.qxmd.com/read/38521410/use-of-eculizumab-in-pediatric-patients-with-high-risk-transplant-associated-thrombotic-microangiopathy-outcomes-and-risk-factors-associated-with-response-and-survival-a-retrospective-study-on-behalf-of-the-spanish-group-for-hematopoietic-transplantation-and
#15
JOURNAL ARTICLE
M I Benítez-Carabante, D Bueno, L Alonso García, I López Torija, J Marsal, Fernandez NavarroJM, M L Uria Oficialdegui, M Panesso, B Molina, C Beléndez Bieler, P Palomo, A Pérez Martínez, C Diaz-de-Heredia
INTRODUCTION: Transplant-associated thrombotic microangiopathy (TA-TMA) is associated with high morbidity and mortality. Although with the introduction of eculizumab the survival has significantly improved, there is still a need for improvement, especially in high-risk patients. OBJECTIVES: This study aims to describe the results obtained with eculizumab in a pediatric cohort with the attempt to define which risk factors could determine the response to treatment...
March 21, 2024: Transplantation and cellular therapy
https://read.qxmd.com/read/38519141/cxcr4-from-b-cell-development-to-b-cell-mediated-diseases
#16
REVIEW
Stéphane Giorgiutti, Julien Rottura, Anne-Sophie Korganow, Vincent Gies
Chemokine receptors are members of the G protein-coupled receptor superfamily. The C-X-C chemokine receptor type 4 (CXCR4), one of the most studied chemokine receptors, is widely expressed in hematopoietic and immune cell populations. It is involved in leukocyte trafficking in lymphoid organs and inflammatory sites through its interaction with its natural ligand CXCL12. CXCR4 assumes a pivotal role in B-cell development, ranging from early progenitors to the differentiation of antibody-secreting cells. This review emphasizes the significance of CXCR4 across the various stages of B-cell development, including central tolerance, and delves into the association between CXCR4 and B cell-mediated disorders, from immunodeficiencies such as WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome to autoimmune diseases such as systemic lupus erythematosus...
June 2024: Life Science Alliance
https://read.qxmd.com/read/38518784/the-histone-acetyltransferase-kat6b-is-required-for-hematopoietic-stem-cell-development-and-function
#17
JOURNAL ARTICLE
Maria I Bergamasco, Nishika Ranathunga, Waruni Abeysekera, Connie S N Li-Wai-Suen, Alexandra L Garnham, Simon N Willis, Helen M McRae, Yuqing Yang, Angela D'Amico, Ladina Di Rago, Stephen Wilcox, Stephen L Nutt, Warren S Alexander, Gordon K Smyth, Anne K Voss, Tim Thomas
The histone lysine acetyltransferase KAT6B (MYST4, MORF, QKF) is the target of recurrent chromosomal translocations causing hematological malignancies with poor prognosis. Using Kat6b germline deletion and overexpression in mice, we determined the role of KAT6B in the hematopoietic system. We found that KAT6B sustained the fetal hematopoietic stem cell pool but did not affect viability or differentiation. KAT6B was essential for normal levels of histone H3 lysine 9 (H3K9) acetylation but not for a previously proposed target, H3K23...
March 11, 2024: Stem Cell Reports
https://read.qxmd.com/read/38518524/radioprotective-effectiveness-of-a-novel-delta-tocotrienol-prodrug-on-mouse-hematopoietic-system-against-60-co-gamma-ray-irradiation-through-inducing-granulocyte-colony-stimulating-factor-production
#18
JOURNAL ARTICLE
Zongchao Zuo, Limei Wang, Shaozheng Wang, Xinyu Liu, Dandan Wu, Zhangyi Ouyang, Ruoxi Meng, Yajun Shan, Shouguo Zhang, Tao Peng, Lin Wang, Zhongtang Li, Yuwen Cong
Considering the increasing risk of nuclear attacks worldwide, the development of develop potent and safe radioprotective agents for nuclear emergencies is urgently needed. γ-tocotrienol (GT3) and δ-tocotrienol (DT3) have demonstrated a potent radioprotective effect by inducing the production of granulocyte-colony stimulating factor (G-CSF) in vivo. However, their application is limited because of their low bioavailability. The utilization of ester prodrugs can be an effective strategy for modifying the pharmacokinetic properties of drug molecules...
March 19, 2024: European Journal of Medicinal Chemistry
https://read.qxmd.com/read/38518064/lessons-learned-from-ocular-graft-versus-host-disease-an-ocular-surface-inflammatory-disease-of-known-time-of-onset
#19
JOURNAL ARTICLE
Manuel E Quiroga-Garza, Raul E Ruiz-Lozano, Luis A Rodriguez-Gutierrez, Ali Khodor, Symon Ma, Seitaro Komai, Karim Mohamed-Noriega, Victor L Perez
The ocular surface inflammatory disorders (OSIDs) comprise a group of conditions characterized by persistent inflammation of the ocular surface and adnexal tissues. Systemic autoimmune diseases and hypersensitivity reactions cause them, and, if left untreated, can result in severe inflammatory dry eye, corneal damage, and vision loss. Ocular graft-versus-host disease (oGVHD) forms part of the ocular surface inflammatory disease umbrella. It is a condition occurring after allogeneic hematopoietic stem cell or bone marrow transplantation, usually in chronic graft-versus-host disease...
March 22, 2024: Eye & Contact Lens
https://read.qxmd.com/read/38518015/the-role-of-gata-family-transcriptional-factors-in-haematological-malignancies-a-review
#20
REVIEW
Dennis Akongfe Abunimye, Ifeyinwa Maryanne Okafor, Henshew Okorowo, Emmanuel Ifeanyi Obeagu
GATA transcriptional factors are zinc finger DNA binding proteins that regulate transcription during development and cell differentiation. The 3 important GATA transcription factors GATA1, GATA2 and GATA3 play essential role in the development and maintenance of hematopoietic systems. GATA1 is required for the erythroid and Megakaryocytic commitment during hematopoiesis. GATA2 is crucial for the proliferation and survival of early hematopoietic cells, and is also involved in lineage specific transcriptional regulation as the dynamic partner of GATA1...
March 22, 2024: Medicine (Baltimore)
keyword
keyword
117710
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.