keyword
MENU ▼
Read by QxMD icon Read
search

maic

keyword
https://www.readbyqxmd.com/read/29906595/differential-drug-susceptibility-patterns-of-mycobacterium-chimaera-and-other-members-of-the-mycobacterium-avium-intracellulare-complex
#1
Florian P Maurer, Philipp Pohle, Margrit Kernbach, Daniela Sievert, Doris Hillemann, Jan Rupp, Michael Hombach, Katharina Kranzer
OBJECTIVES: To determine MIC distributions for Mycobacterium chimaera, Mycobacterium intracellulare, Mycobacterium colombiense and Mycobacterium avium, and to derive tentative epidemiological cutoff (ECOFF) values. METHODS: 683 bacterial isolates (M. chimaera, n = 203; M. intracellulare; n = 77; M. colombiense, n = 68; M. avium, n = 335) from 627 patients were tested by broth microdilution according to CLSI protocol M24-A2 on Sensititre RAPMYCOI plates. MICs were interpreted based on CLSI breakpoints for clarithromycin, and tentative breakpoints for amikacin, moxifloxacin and linezolid...
June 12, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29861642/matching-adjusted-indirect-treatment-comparison-of-ribociclib-and-palbociclib-in-hr-her2-advanced-breast-cancer
#2
Gabriel Tremblay, David Chandiwana, Mike Dolph, Jaclyn Hearnden, Anna Forsythe, Mauricio Monaco
Background: Ribociclib (RIBO) and palbociclib (PALBO), combined with letrozole (LET), have been evaluated as treatments for hormone receptor-positive, human epidermal growth factor receptor 2-negative advanced breast cancer in separate Phase III randomized controlled trials (RCTs), but not head-to-head. Population differences can lead to biased results by classical indirect treatment comparison (ITC). Matching-adjusted indirect comparison (MAIC) aims to correct these differences. We compared RIBO and PALBO in hormone receptor-positive/human epidermal growth factor receptor 2-negative advanced breast cancer using MAIC...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29480454/ponatinib-for-treating-chronic-myeloid-leukaemia-an-evidence-review-group-perspective-of-a-nice-single-technology-appraisal
#3
REVIEW
Abdullah Pandor, Matt Stevenson, John Stevens, Marrissa Martyn-St James, Jean Hamilton, Jenny Byrne, Claudius Rudin, Andrew Rawdin, Ruth Wong
As part of its single technology appraisal process, the National Institute for Health and Care Excellence (NICE) invited the company that manufactures ponatinib (Inclusig® ; Incyte Corporation) to submit evidence for the clinical and cost effectiveness for previously treated chronic myeloid leukaemia (CML) and Philadelphia-chromosome-positive acute lymphoblastic leukaemia (Ph+ ALL). This paper focusses on the three phases of CML: the chronic phase (CP), the accelerated phase (AP) and the blast crisis phase (BP)...
February 26, 2018: PharmacoEconomics
https://www.readbyqxmd.com/read/29192016/comparative-efficacy-of-daratumumab-monotherapy-and-pomalidomide-plus-low-dose-dexamethasone-in-the-treatment-of-multiple-myeloma-a-matching-adjusted-indirect-comparison
#4
Suzy Van Sanden, Tetsuro Ito, Joris Diels, Martin Vogel, Andrew Belch, Albert Oriol
BACKGROUND: Daratumumab (a human CD38-directed monoclonal antibody) and pomalidomide (an immunomodulatory drug) plus dexamethasone are both relatively new treatment options for patients with heavily pretreated multiple myeloma. A matching adjusted indirect comparison (MAIC) was used to compare absolute treatment effects of daratumumab versus pomalidomide + low-dose dexamethasone (LoDex; 40 mg) on overall survival (OS), while adjusting for differences between the trial populations...
March 2018: Oncologist
https://www.readbyqxmd.com/read/29126800/nanoencapsulated-illicium-verum-hook-f-essential-oil-as-an-effective-novel-plant-based-preservative-against-aflatoxin-b-1-production-and-free-radical-generation
#5
Abhishek Kumar Dwivedy, Vipin Kumar Singh, Bhanu Prakash, Nawal Kishore Dubey
The study reports efficacy of Illicium verum essential oil (IvEO) against food borne moudls and its nanoencapsulation for enhancing antifungal and antiaflatoxigenic potency. Chemical characterization of the IvEO showed anethole (89.12%) as major compound followed by estragole (4.859%). The IvEO showed broad fungitoxic spectrum against common food borne moulds. It's minimum inhibitory concentration (MIC) and minimum aflatoxin B1 inhibitory concentration (MAIC) against aflatoxigenic strain Aspergillus flavus LHP-PV-1 were 0...
January 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28971316/resveratrol-pterostilbene-and-baicalein-plant-derived-anti-biofilm-agents
#6
Irena Kolouchová, Olga Maťátková, Martina Paldrychová, Zdeněk Kodeš, Eva Kvasničková, Karel Sigler, Alena Čejková, Jan Šmidrkal, Kateřina Demnerová, Jan Masák
Microbial adhesion to surfaces and the subsequent biofilm formation may result in contamination in food industry and in healthcare-associated infections and may significantly affect postoperative care. Some plants produce substances with antioxidant and antimicrobial properties that are able to inhibit the growth of food-borne pathogens. The aim of our study was to evaluate antimicrobial and anti-biofilm effect of baicalein, resveratrol, and pterostilbene on Candida albicans, Staphylococcus epidermidis, Pseudomonas aeruginosa, and Escherichia coli...
May 2018: Folia Microbiologica
https://www.readbyqxmd.com/read/28607774/a-matching-adjusted-indirect-comparison-of-sonidegib-and-vismodegib-in-advanced-basal-cell-carcinoma
#7
Dawn Odom, Deirdre Mladsi, Molly Purser, James A Kaye, Eirini Palaka, Alina Charter, Jo Annah Jensen, Dalila Sellami
OBJECTIVES: Based on single-arm trial data (BOLT), sonidegib was approved in the US and EU to treat locally advanced basal cell carcinomas (BCCs) ineligible for curative surgery or radiotherapy. Vismodegib, the other approved targeted therapy, also was assessed in a single-arm trial (ERIVANCE). We examined the comparative effectiveness of the two drugs using a matching-adjusted indirect comparison (MAIC) versus an unadjusted indirect comparison. METHODS: After comparing trials and identifying potential prognostic factors, an MAIC was conducted to adjust for differences in key patient baseline characteristics...
2017: Journal of Skin Cancer
https://www.readbyqxmd.com/read/28573505/comparative-efficacy-of-ibrutinib-versus-obinutuzumab-chlorambucil-in-first-line-treatment-of-chronic-lymphocytic-leukemia-a-matching-adjusted-indirect-comparison
#8
COMPARATIVE STUDY
Suzy Van Sanden, Simona Baculea, Joris Diels, Sarah Cote
INTRODUCTION: Ibrutinib (ibr) monotherapy and the combination of obinutuzumab plus chlorambucil (obi) are approved for previously untreated chronic lymphocytic leukemia (CLL). No trials directly comparing their efficacy are available. Therefore a matching-adjusted indirect comparison (MAIC) was performed to provide insight into their relative efficacy in terms of progression-free survival (PFS) and overall survival (OS). MAIC attempts to adjust for between-trial differences in factors known or suspected to influence treatment effects, to minimize bias...
July 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28552513/chemically-characterized-mentha-cardiaca-l-essential-oil-as-plant-based-preservative-in-view-of-efficacy-against-biodeteriorating-fungi-of-dry-fruits-aflatoxin-secretion-lipid-peroxidation-and-safety-profile-assessment
#9
Abhishek Kumar Dwivedy, Bhanu Prakash, Chandan Singh Chanotiya, Deepa Bisht, Nawal Kishore Dubey
The study reports Mentha cardiaca essential oil (EO) as plant based preservative against fungal and aflatoxin contamination of stored dry fruits. Mycoflora analysis of the dry fruits revealed Aspergillus favus LHP-PV-1 as the most aflatoxigenic isolate with highest Aflatoxin B1 content. M. cardiaca EO showed broad fungitoxic spectrum inhibiting the tested moulds contaminating dry fruits. It's minimum inhibitory concentration (MIC), minimum aflatoxin inhibitory concentration (MAIC) and minimum fungicidal concentration (MFC) against A...
August 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28382213/integrated-services-and-early-intervention-in-the-vocational-rehabilitation-of-people-with-spinal-cord-injuries
#10
Julia Bloom, Pat Dorsett, Vanette McLennan
INTRODUCTION: The design was a narrative review. The objective of the study was to investigate the potential for early vocational rehabilitation (VR) interventions for people with spinal cord injury (SCI) in overcoming barriers in returning to work, and to pinpoint factors contributing to effectiveness in early VR intervention for this population. The setting was at Queensland, Australia. MATERIALS AND METHODS: Synthesis of the findings of a literature search of online databases ProQuest and CINAHL, using keywords relating to the employment situation and VR of people with SCI...
2017: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/28361159/evaluation-of-adjusted-and-unadjusted-indirect-comparison-methods-in-benefit-assessment-a-simulation-study-for-time-to-event-endpoints
#11
COMPARATIVE STUDY
Sarah Kühnast, Julia Schiffner-Rohe, Jörg Rahnenführer, Friedhelm Leverkus
BACKGROUND: With the Act on the Reform of the Market for Medicinal Products (AMNOG) in Germany, pharmaceutical manufacturers are obliged to submit a dossier demonstrating added benefit of a new drug compared to an appropriate comparator. Underlying evidence was planned for registration purposes and therefore often does not meet the appropriate comparator as defined by the Federal Joint Committee (G-BA). For this reason AMNOG allows indirect comparisons to assess the extent of added benefit...
May 18, 2017: Methods of Information in Medicine
https://www.readbyqxmd.com/read/28106929/conformational-analysis-of-an-antibacterial-cyclodepsipeptide-active-against-mycobacterium-tuberculosis-by-a-combined-roe-and-rdc-analysis
#12
Maic Fredersdorf, Michael Kurz, Armin Bauer, Marc-Olivier Ebert, Carla Rigling, Laurie Lannes, Christina Marie Thiele
Griselimycin (GM) and methylgriselimycin (MGM), naturally produced by microorganisms of the genus Streptomyces, are cyclic depsipeptides composed of ten amino acids. They exhibit antibacterial activity against Mycobacterium species by inhibiting the sliding clamp of prokaryotic DNA polymerase III and are therefore considered as potential anti-tuberculosis drugs. The difference between the peptides is the presence of l-(R)-4-methyl-proline in MGM instead of l-proline in GM at position 8 of the amino acid sequence...
April 27, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27972407/comparative-efficacy-of-daratumumab-monotherapy-and-pomalidomide-plus-low-dose-dexamethasone-poma-lodex-in-the-treatment-of-multiple-myeloma-a-matching-adjusted-indirect-comparison-maic
#13
S van Sanden, T Ito, M Vogel, J Diels
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27971669/matching-adjusted-indirect-comparison-maic-analysis-for-ponatinib-vs-bosutinib-in-third-line-chronic-phase-chronic-myeloid-leukemia-cp-cml
#14
S Iannazzo, L McGarry, S Lustgarten, S Chiroli
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27971516/feasibility-of-matching-adjusted-indirect-comparison-maic-of-omalizumab-oma-vs-mepolizumab-mepo-in-moderate-to-severe-asthma
#15
R Ayyagari, L Álvares, F Mu, V Hacking, R Martinez, J E Signorovitch
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27970663/watch-out-for-berkson-s-bias-bb-setting-health-related-quality-of-life-hrqol-treatment-targets-with-matching-adjusted-indirect-comparison-maic-in-order-to-predict-matched-general-population-control-mgpc-targets-assess-potential-to-benefit-ptb-and-reveal-unmet
#16
E J Soini, J Heinonen, E Miettola, O Ryynänen, T Koskela
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27879043/uncovering-key-structural-features-of-an-enantioselective-peptide-catalyzed-acylation-utilizing-advanced-nmr-techniques
#17
Eliška Procházková, Andreas Kolmer, Julian Ilgen, Mira Schwab, Lukas Kaltschnee, Maic Fredersdorf, Volker Schmidts, Raffael C Wende, Peter R Schreiner, Christina M Thiele
We report on a detailed NMR spectroscopic study of the catalyst-substrate interaction of a highly enantioselective oligopeptide catalyst that is used for the kinetic resolution of trans-cycloalkane-1,2-diols via monoacylation. The extraordinary selectivity has been rationalized by molecular dynamics as well as density functional theory (DFT) computations. Herein we describe the conformational analysis of the organocatalyst studied by a combination of nuclear Overhauser effect (NOE) and residual dipolar coupling (RDC)-based methods that resulted in an ensemble of four final conformers...
December 19, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27620206/evaluating-matching-adjusted-indirect-comparisons-in-practice-a-case-study-of-patients-with-attention-deficit-hyperactivity-disorder
#18
Jason Shafrin, Anshu Shrestha, Amitabh Chandra, M Haim Erder, Vanja Sikirica
Differences in patient characteristics across trials may bias efficacy estimates from indirect treatment comparisons. To address this issue, matching-adjusted indirect comparison (MAIC) measures treatment efficacy after weighting individual patient data to match patient characteristics across trials. To date, however, there is no consensus on how best to implement MAIC. To address this issue, we applied MAIC to measure how two attention-deficit/hyperactivity disorder (ADHD) treatments (guanfacine extended release and atomoxetine hydrochloride) affect patients' ADHD symptoms, as measured by the ADHD Rating Scale IV score...
September 13, 2016: Health Economics
https://www.readbyqxmd.com/read/27445511/matching-adjusted-indirect-comparisons-of-efficacy-of-bay-81-8973-vs-two-recombinant-factor-viii-for-the-prophylactic-treatment-of-severe-hemophilia-a
#19
Jennifer Pocoski, Nanxin Li, Rajeev Ayyagari, Nikki Church, Monika Maas Enriquez, Quer Xiang, Sneha Kelkar, Ella X Du, Eric Q Wu, Jipan Xie
BACKGROUND: No head-to-head trials comparing recombinant factor VIII (rFVIII) products currently exist. This was a matching-adjusted indirect comparison (MAIC) study of efficacy of BAY 81-8973 with antihemophilic factor (recombinant) plasma/albumin-free method (rAHF-PFM) and turoctocog alfa for the prophylaxis of severe hemophilia A. METHODS: A systematic literature review was conducted to identify trials of rAHF-PFM and turoctocog alfa. Comparisons were conducted using BAY 81-8973 individual patient data (IPD) from LEOPOLD trials and published data from rAHF-PFM and turoctocog alfa trials...
2016: Journal of Blood Medicine
https://www.readbyqxmd.com/read/27116943/a-scoping-review-of-indirect-comparison-methods-and-applications-using-individual-patient-data
#20
REVIEW
Areti Angeliki Veroniki, Sharon E Straus, Charlene Soobiah, Meghan J Elliott, Andrea C Tricco
BACKGROUND: Several indirect comparison methods, including network meta-analyses (NMAs), using individual patient data (IPD) have been developed to synthesize evidence from a network of trials. Although IPD indirect comparisons are published with increasing frequency in health care literature, there is no guidance on selecting the appropriate methodology and on reporting the methods and results. METHODS: In this paper we examine the methods and reporting of indirect comparison methods using IPD...
April 27, 2016: BMC Medical Research Methodology
keyword
keyword
117709
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"