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https://www.readbyqxmd.com/read/28607774/a-matching-adjusted-indirect-comparison-of-sonidegib-and-vismodegib-in-advanced-basal-cell-carcinoma
#1
Dawn Odom, Deirdre Mladsi, Molly Purser, James A Kaye, Eirini Palaka, Alina Charter, Jo Annah Jensen, Dalila Sellami
OBJECTIVES: Based on single-arm trial data (BOLT), sonidegib was approved in the US and EU to treat locally advanced basal cell carcinomas (BCCs) ineligible for curative surgery or radiotherapy. Vismodegib, the other approved targeted therapy, also was assessed in a single-arm trial (ERIVANCE). We examined the comparative effectiveness of the two drugs using a matching-adjusted indirect comparison (MAIC) versus an unadjusted indirect comparison. METHODS: After comparing trials and identifying potential prognostic factors, an MAIC was conducted to adjust for differences in key patient baseline characteristics...
2017: Journal of Skin Cancer
https://www.readbyqxmd.com/read/28573505/comparative-efficacy-of-ibrutinib-versus-obinutuzumab%C3%A2-%C3%A2-chlorambucil-in-first-line-treatment-of-chronic-lymphocytic-leukemia-a-matching-adjusted-indirect-comparison
#2
Suzy Van Sanden, Simona Baculea, Joris Diels, Sarah Cote
INTRODUCTION: Ibrutinib (ibr) monotherapy and the combination of obinutuzumab plus chlorambucil (obi) are approved for previously untreated chronic lymphocytic leukemia (CLL). No trials directly comparing their efficacy are available. Therefore a matching-adjusted indirect comparison (MAIC) was performed to provide insight into their relative efficacy in terms of progression-free survival (PFS) and overall survival (OS). MAIC attempts to adjust for between-trial differences in factors known or suspected to influence treatment effects, to minimize bias...
June 1, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28552513/chemically-characterized-mentha-cardiaca-l-essential-oil-as-plant-based-preservative-in-view-of-efficacy-against-biodeteriorating-fungi-of-dry-fruits-aflatoxin-secretion-lipid-peroxidation-and-safety-profile-assessment
#3
Abhishek Kumar Dwivedy, Bhanu Prakash, Chandan Singh Chanotiya, Deepa Bisht, Nawal Kishore Dubey
The study reports Mentha cardiaca essential oil (EO) as plant based preservative against fungal and aflatoxin contamination of stored dry fruits. Mycoflora analysis of the dry fruits revealed Aspergillus favus LHP-PV-1 as the most aflatoxigenic isolate with highest Aflatoxin B1 content. M. cardiaca EO showed broad fungitoxic spectrum inhibiting the tested moulds contaminating dry fruits. It's minimum inhibitory concentration (MIC), minimum aflatoxin inhibitory concentration (MAIC) and minimum fungicidal concentration (MFC) against A...
May 24, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28382213/integrated-services-and-early-intervention-in-the-vocational-rehabilitation-of-people-with-spinal-cord-injuries
#4
Julia Bloom, Pat Dorsett, Vanette McLennan
INTRODUCTION: The design was a narrative review. The objective of the study was to investigate the potential for early vocational rehabilitation (VR) interventions for people with spinal cord injury (SCI) in overcoming barriers in returning to work, and to pinpoint factors contributing to effectiveness in early VR intervention for this population. The setting was at Queensland, Australia. MATERIALS AND METHODS: Synthesis of the findings of a literature search of online databases ProQuest and CINAHL, using keywords relating to the employment situation and VR of people with SCI...
2017: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/28361159/evaluation-of-adjusted-and-unadjusted-indirect-comparison-methods-in-benefit-assessment-a-simulation-study-for-time-to-event-endpoints
#5
Sarah Kühnast, Julia Schiffner-Rohe, Jörg Rahnenführer, Friedhelm Leverkus
BACKGROUND: With the Act on the Reform of the Market for Medicinal Products (AMNOG) in Germany, pharmaceutical manufacturers are obliged to submit a dossier demonstrating added benefit of a new drug compared to an appropriate comparator. Underlying evidence was planned for registration purposes and therefore often does not meet the appropriate comparator as defined by the Federal Joint Committee (G-BA). For this reason AMNOG allows indirect comparisons to assess the extent of added benefit...
March 31, 2017: Methods of Information in Medicine
https://www.readbyqxmd.com/read/28106929/conformational-analysis-of-an-antibacterial-cyclodepsipeptide-active-against-mycobacterium-tuberculosis-by-a-combined-roe-and-rdc-analysis
#6
Maic Fredersdorf, Michael Kurz, Armin Bauer, Marc-Olivier Ebert, Carla Rigling, Laurie Lannes, Christina Marie Thiele
Griselimycin (GM) and methylgriselimycin (MGM), naturally produced by microorganisms of the genus Streptomyces, are cyclic depsipeptides composed of ten amino acids. They exhibit antibacterial activity against Mycobacterium species by inhibiting the sliding clamp of prokaryotic DNA polymerase III and are therefore considered as potential anti-tuberculosis drugs. The difference between the peptides is the presence of l-(R)-4-methyl-proline in MGM instead of l-proline in GM at position 8 of the amino acid sequence...
January 20, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27972407/comparative-efficacy-of-daratumumab-monotherapy-and-pomalidomide-plus-low-dose-dexamethasone-poma-lodex-in-the-treatment-of-multiple-myeloma-a-matching-adjusted-indirect-comparison-maic
#7
S van Sanden, T Ito, M Vogel, J Diels
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27971669/matching-adjusted-indirect-comparison-maic-analysis-for-ponatinib-vs-bosutinib-in-third-line-chronic-phase-chronic-myeloid-leukemia-cp-cml
#8
S Iannazzo, L McGarry, S Lustgarten, S Chiroli
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27971516/feasibility-of-matching-adjusted-indirect-comparison-maic-of-omalizumab-oma-vs-mepolizumab-mepo-in-moderate-to-severe-asthma
#9
R Ayyagari, L Álvares, F Mu, V Hacking, R Martinez, J E Signorovitch
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27970663/watch-out-for-berkson-s-bias-bb-setting-health-related-quality-of-life-hrqol-treatment-targets-with-matching-adjusted-indirect-comparison-maic-in-order-to-predict-matched-general-population-control-mgpc-targets-assess-potential-to-benefit-ptb-and-reveal-unmet
#10
E J Soini, J Heinonen, E Miettola, O Ryynänen, T Koskela
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27879043/uncovering-key-structural-features-of-an-enantioselective-peptide-catalyzed-acylation-utilizing-advanced-nmr-techniques
#11
Eliška Procházková, Andreas Kolmer, Julian Ilgen, Mira Schwab, Lukas Kaltschnee, Maic Fredersdorf, Volker Schmidts, Raffael C Wende, Peter R Schreiner, Christina M Thiele
We report on a detailed NMR spectroscopic study of the catalyst-substrate interaction of a highly enantioselective oligopeptide catalyst that is used for the kinetic resolution of trans-cycloalkane-1,2-diols via monoacylation. The extraordinary selectivity has been rationalized by molecular dynamics as well as density functional theory (DFT) computations. Herein we describe the conformational analysis of the organocatalyst studied by a combination of nuclear Overhauser effect (NOE) and residual dipolar coupling (RDC)-based methods that resulted in an ensemble of four final conformers...
December 19, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27620206/evaluating-matching-adjusted-indirect-comparisons-in-practice-a-case-study-of-patients-with-attention-deficit-hyperactivity-disorder
#12
Jason Shafrin, Anshu Shrestha, Amitabh Chandra, M Haim Erder, Vanja Sikirica
Differences in patient characteristics across trials may bias efficacy estimates from indirect treatment comparisons. To address this issue, matching-adjusted indirect comparison (MAIC) measures treatment efficacy after weighting individual patient data to match patient characteristics across trials. To date, however, there is no consensus on how best to implement MAIC. To address this issue, we applied MAIC to measure how two attention-deficit/hyperactivity disorder (ADHD) treatments (guanfacine extended release and atomoxetine hydrochloride) affect patients' ADHD symptoms, as measured by the ADHD Rating Scale IV score...
September 13, 2016: Health Economics
https://www.readbyqxmd.com/read/27445511/matching-adjusted-indirect-comparisons-of-efficacy-of-bay-81-8973-vs-two-recombinant-factor-viii-for-the-prophylactic-treatment-of-severe-hemophilia-a
#13
Jennifer Pocoski, Nanxin Li, Rajeev Ayyagari, Nikki Church, Monika Maas Enriquez, Quer Xiang, Sneha Kelkar, Ella X Du, Eric Q Wu, Jipan Xie
BACKGROUND: No head-to-head trials comparing recombinant factor VIII (rFVIII) products currently exist. This was a matching-adjusted indirect comparison (MAIC) study of efficacy of BAY 81-8973 with antihemophilic factor (recombinant) plasma/albumin-free method (rAHF-PFM) and turoctocog alfa for the prophylaxis of severe hemophilia A. METHODS: A systematic literature review was conducted to identify trials of rAHF-PFM and turoctocog alfa. Comparisons were conducted using BAY 81-8973 individual patient data (IPD) from LEOPOLD trials and published data from rAHF-PFM and turoctocog alfa trials...
2016: Journal of Blood Medicine
https://www.readbyqxmd.com/read/27116943/a-scoping-review-of-indirect-comparison-methods-and-applications-using-individual-patient-data
#14
Areti Angeliki Veroniki, Sharon E Straus, Charlene Soobiah, Meghan J Elliott, Andrea C Tricco
BACKGROUND: Several indirect comparison methods, including network meta-analyses (NMAs), using individual patient data (IPD) have been developed to synthesize evidence from a network of trials. Although IPD indirect comparisons are published with increasing frequency in health care literature, there is no guidance on selecting the appropriate methodology and on reporting the methods and results. METHODS: In this paper we examine the methods and reporting of indirect comparison methods using IPD...
2016: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/26455472/indirect-comparison-of-the-antiviral-efficacy-of-peginterferon-alpha-2a-plus-ribavirin-used-with-or-without-simeprevir-in-genotype-4-hepatitis-c-virus-infection-where-common-comparator-study-arms-are-lacking-a-special-application-of-the-matching-adjusted-indirect
#15
COMPARATIVE STUDY
Suzy Van Sanden, Marta Pisini, Inge Duchesne, Angelika Mehnert, Jonathan Belsey
BACKGROUND: The need to assess relative efficacy in the absence of comparative clinical trials is a problem that is often encountered in economic modeling. The use of matching adjusted indirect comparison (MAIC) in this situation has been suggested. We present the results of a MAIC used to evaluate the incremental benefit offered by adding simeprevir (SMV) to standard therapy in the treatment of patients infected with genotype 4 hepatitis C virus (HCV). METHODS: Individual patient data for a single arm study evaluating the use of SMV with peginterferon alfa 2a + ribavirin (PR) in genotype 4 HCV were available (RESTORE study)...
2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/26298451/exploring-the-conformational-space-of-bridge-substituted-dithienylcyclopentenes
#16
Maic Fredersdorf, Robert Göstl, Andreas Kolmer, Volker Schmidts, Peter Monecke, Stefan Hecht, Christina M Thiele
Stimuli responsive compounds and materials are of high interest in synthetic chemistry and materials science, with light being the most intriguing stimulus due to the possibility to remote control the physicochemical properties of a molecule or a material. There is a constant quest to design photoswitches with improved switching efficiency and especially diarylethene-type switches promise photo cyclization quantum yields up to unity. However, only limited attention has been paid towards the influence of the solution conformation on the switching efficiency...
October 5, 2015: Chemistry: a European Journal
https://www.readbyqxmd.com/read/26159375/comparative-efficacy-and-safety-of-daclatasvir-asunaprevir-versus-ifn-based-regimens-in-genotype-1b-hepatitis-c-virus-infection
#17
REVIEW
James E Signorovitch, Keith A Betts, Yan Song, Rachael A Sorg, Junlong Li, Ajay S Behl, Anupama Kalsekar
AIM: Efficacy and safety comparison of daclatasvir/asunaprevir (DCV + ASV) versus peginterferon-α/ribavirin (A/R) alone or combined with telaprevir, boceprevir, simeprevir or sofosbuvir in chronic genotype 1b hepatitis C virus infection. METHODS: Network meta-analysis (NMA) and matching-adjusted indirect comparisons (MAICs). RESULTS: Among treatment-naive patients, DCV + ASV demonstrated higher sustained virologic response (SVR) rates than telaprevir + A/R, boceprevir + A/R and A/R in NMA and MAICs and simeprevir + A/R in NMA...
November 2015: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/24121470/dmso-enhanced-maldi-ms-imaging-with-normalization-against-a-deuterated-standard-for-relative-quantification-of-dasatinib-in-serial-mouse-pharmacology-studies
#18
Sandra Schulz, Dimitri Gerhardt, Björn Meyer, Maic Seegel, Bernhard Schubach, Carsten Hopf, Katerina Matheis
Matrix-assisted laser desorption/ionization mass spectrometry imaging is an emerging powerful technique in drug metabolism and pharmacokinetics research. Despite recent progress in mass-spectrometry-based localization and relative quantification of small-molecule drugs and their metabolites in tissue, improved methods for drug extraction/ionization are required. Furthermore, relative quantification of drugs by mass spectrometry imaging in larger rodent cohorts is a necessary proof-of-concept study to demonstrate the utility of such a workflow in an industrial setting...
November 2013: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/23975660/comparative-efficacy-of-guanfacine-extended-release-versus-atomoxetine-for-the-treatment-of-attention-deficit-hyperactivity-disorder-in-children-and-adolescents-applying-matching-adjusted-indirect-comparison-methodology
#19
COMPARATIVE STUDY
Vanja Sikirica, Robert L Findling, James Signorovitch, M Haim Erder, Ryan Dammerman, Paul Hodgkins, Mei Lu, Jipan Xie, Eric Q Wu
BACKGROUND: No head-to-head clinical trials have been published comparing guanfacine extended release (GXR) and atomoxetine (ATX): two nonstimulants approved for the treatment of attention-deficit/hyperactivity disorder (ADHD). However, other study designs or methods could be used to indirectly compare these two medications. Matching-adjusted indirect comparison (MAIC) is a recent methodology that utilizes individual patient data (IPD) from clinical trials for one treatment and published aggregate data from another treatment to estimate the relative efficacy of both, providing rapid, reliable comparative efficacy results...
November 2013: CNS Drugs
https://www.readbyqxmd.com/read/23659349/rdc-based-determination-of-the-relative-configuration-of-the-fungicidal-cyclopentenone-4-6-diacetylhygrophorone-a12
#20
Volker Schmidts, Maic Fredersdorf, Tilo Lübken, Andrea Porzel, Norbert Arnold, Ludger Wessjohann, Christina M Thiele
The hygrophorones, a class of cyclopentenones isolated from fruiting bodies of the genus Hygrophorus (basidiomycetes), show promising antifungal activity. While the constitution of 4,6-diacetylhygrophorone A(12) (3) and the relative configuration of the stereogenic centers in the cyclopentenone ring were elucidated using standard NMR and MS techniques, the relative configuration of the exocyclic stereogenic center could not be assigned. By introducing a sample of 3 into an alignment medium and measuring anisotropic NMR parameters, namely, residual dipolar couplings, we were able to unambiguously determine the relative configuration of all three stereogenic centers in 4,6-diacetylhygrophorone A(12) simultaneously by fitting several structure proposals to the experimental data...
May 24, 2013: Journal of Natural Products
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