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https://www.readbyqxmd.com/read/29335806/assessment-of-ocular-toxoplasmosis-patients-reported-at-a-tertiary-center-in-the-northeast-of-iran
#1
SeyedehMaryam Hosseini, Elham Moghaddas, Karim Sharifi, Malihe Dadgar Moghaddam, Seyed Aliakbar Shamsian
PURPOSE: Ocular toxoplasmosis, which is caused by the single-cell parasite Toxoplasma gondii, is currently the most significant cause of posterior uveitis in the world. No previous studies have described the prevalence and clinical features of ocular toxoplasmosis in the northeast of Iran. The purpose of the current study was to address this gap. METHODS: In this retrospective study, the medical records of 488 uveitis patients who presented to the Khatam-al-Anbia Eye Hospital of Mashhad University of Medical Sciences, a tertiary ophthalmology center in the northeast of Iran, between January 2013 and December 2015 were evaluated...
January 15, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29283732/seroprevalence-and-manifestations-of-ocular-toxoplasmosis-in-patients-with-schizophrenia
#2
Fábio Barreto Morais, Tiago Eugênio Faria E Arantes, Cristina Muccioli
PURPOSE: Recent studies have linked infectious agents such as Toxoplasma gondii to schizophrenia. We investigated the seroprevalence of T. gondii and conducted ophthalmologic examinations in schizophrenia patients and controls to identify lesions suggestive of ocular toxoplasmosis. METHODS: During 2015 and 2016, 34 schizophrenia patients and 85 healthy controls underwent ophthalmologic examination and anti-T. gondii IgG and IgM antibody measurements by chemiluminescence...
December 28, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29221851/ccr5-chemokine-receptor-gene-polymorphisms-in-ocular-toxoplasmosis
#3
Geraldo M de Faria, Christiane M Ayo, Amanda P de Oliveira, Alessandro G Lopes, Fábio B Frederico, Aparecida P Silveira-Carvalho, Mariana Previato, Amanda P Barbosa, Fernando H A Murata, Gildásio Castello de Almeida, Rubens Camargo Siqueira, Luiz C de Mattos, Cinara C Brandão de Mattos
C-C chemokine receptor type 5 (CCR5) is a chemokine receptor that influences the immune response to infectious and parasitic diseases. This study aimed to determine whether the CCR5Δ32 and CCR5 59029 A/G polymorphisms are associated with the development of ocular toxoplasmosis in humans. Patients with positive serology for Toxoplasma gondii were analyzed and grouped as 'with ocular toxoplasmosis' (G1: n=160) or 'without ocular toxoplasmosis' (G2: n=160). A control group (G3) consisted of 160 individuals with negative serology...
December 5, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29197989/direct-genetic-characterization-of-toxoplasma-gondii-from-clinical-samples-from-denmark-not-only-genotypes-ii-and-iii
#4
P Jokelainen, J-B Murat, H V Nielsen
Genetic variation within Toxoplasma gondii can have both clinical and epidemiological significance, while the genotypes circulating in many parts of the world, including the Nordic country Denmark, are still unknown. We genetically characterized T. gondii strains that had been detected in human clinical samples in Denmark in 2011-2016. Samples that had tested positive for T. gondii DNA and had a quantification cycle value <33 were included in this study and subjected to direct genetic characterization of T...
December 3, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29179785/toxoplasma-gondii-reorganizes-the-host-cell-architecture-during-spontaneous-cyst-formation-in-vitro
#5
T C Paredes-Santos, E S Martins-Duarte, W de Souza, M Attias, R C Vommaro
Toxoplasma gondii is an intracellular protozoan parasite that causes toxoplasmosis, a prevalent infection related to abortion, ocular diseases and encephalitis in immuno-compromised individuals. In the untreatable (and life-long) chronic stage of toxoplasmosis, parasitophorous vacuoles (PVs, containing T. gondii tachyzoites) transform into tissue cysts, containing slow-dividing bradyzoite forms. While acute-stage infection with tachyzoites involves global rearrangement of the host cell cytoplasm, focused on favouring tachyzoite replication, the cytoplasmic architecture of cells infected with cysts had not been described...
November 28, 2017: Parasitology
https://www.readbyqxmd.com/read/29177397/-not-everything-is-zika-congenital-toxoplasmosis-still-prevalent-in-colombia
#6
Jorge L Alvarado-Socarras, Keyla Meneses-Silvera, Andrea Carolina Zarate-Vergara, Carlos Guerrero-Gomez, Alfonso J Rodriguez-Morales
Congenital toxoplasmosis continues to be a public health threat. Even existing guidelines, publicly known, its implementation and lack of appropriate interpretation of serological tests in pregnancy is often observed. This leds to failure in opportunities for positive and known interventions to decrease the fetal risk due to Toxoplasma gondii infection. We reported herein a case series, with variable neurological and systemic compromise (respiratory distress, hepatosplenomegaly, enterocolitis, brain calcifications, thrombocytopenia, ascites, shock), even fatal, calling for awareness about the fact that despite the Zika epidemics in 2015-2016 in Brazil, Colombia and other countries, precisely toxoplasmosis, is a differential diagnosis still prevalent in these territories, that can leds to severe consequences, with neurological disability and risk of ocular damage, even lately...
April 2017: Revista Peruana de Medicina Experimental y Salud Pública
https://www.readbyqxmd.com/read/29155634/how-does-imaging-of-congenital-zika-compare-with-imaging-of-other-torch-infections
#7
REVIEW
Deborah Levine, Jacques C Jani, Ilse Castro-Aragon, Mieke Cannie
The acronym TORCH is used to refer to congenital infections, such as toxoplasmosis, other infections (such as syphillis, varicella-zoster, and parvovirus B19), cytomegalovirus, and herpes simplex virus. The classic findings in patients with TORCH infections include rash in the mother during pregnancy and ocular findings in the newborn. Zika virus has emerged as an important worldwide congenital infection. It fits well with other congenital TORCH infections since there is a rash in the mother and there are commonly ocular abnormalities in the newborn...
December 2017: Radiology
https://www.readbyqxmd.com/read/29153066/-age-related-prevalence-of-toxoplasmosis-among-pregnant-women-in-hatay-estimation-depending-on-model
#8
Meryem Çetin, Şirin Çetin
Toxoplasmosis, caused by the obligate intracellular protozoan Toxoplasma gondii, is a common parasitic infection affecting approximately one-third of the world population. T.gondii infections are usually acquired by ingesting raw or insufficiently cooked meat and from unwashed fruits and vegetables contaminated with soil or water with cat feces. Primary infection acquired during pregnancy can cause severe congenital abnormalities in the fetus such as neurologic and ocular malformations, abortion, or stillbirth according to the degree of infection...
October 2017: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/29131528/the-design-of-a-social-cost-benefit-analysis-of-preventive-interventions-for-toxoplasmosis-an-example-of-the-one-health%C3%A2-approach
#9
A W M Suijkerbuijk, P F van Gils, A A Bonačić Marinović, T L Feenstra, L M Kortbeek, M-J J Mangen, M Opsteegh, G A de Wit, J W B van der Giessen
Toxoplasma gondii infections cause a large disease burden in the Netherlands, with an estimated health loss of 1,900 Disability Adjusted Life Years and a cost-of-illness estimated at €44 million annually. Infections in humans occur via exposure to oocysts in the environment and after eating undercooked meat containing tissue cysts, leading to asymptomatic or mild symptoms, but potentially leading to the development of ocular toxoplasmosis. Infection in pregnant women can lead to stillbirth and disorders in newborns...
November 12, 2017: Zoonoses and Public Health
https://www.readbyqxmd.com/read/29077180/large-choroidal-excavation-in-a-patient-with-rubella-retinopathy
#10
Maurizio Battaglia Parodi, Francesco Romano, Marco Montagna, Francesco Bandello
PURPOSE: To describe a case of rubella retinopathy complicated by bilateral choroidal neovascularization (CNV) and late development of large choroidal excavation (LCE). METHODS: A 19-year-old woman with a diagnosis of rubella retinopathy underwent her annual ophthalmologic examination, including visual acuity testing and slit-lamp biomicroscopy with dilated fundus examination. Color fundus photography, spectral-domain optical coherence tomography (SD-OCT) scans, and optical coherence tomography angiography were acquired to complete the investigation of her ocular condition...
October 17, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/29020485/comment-on-intravitreal-injection-of-sulfamethoxazole-and-trimethoprim-associated-with-dexamethasone-as-an-alternative-therapy-for-ocular-toxoplasmosis
#11
Koushik Tripathy
No abstract text is available yet for this article.
October 11, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29020481/ocular-toxoplasmosis-in-tropical-areas-analysis-and-outcome-of-190-patients-from-a-multicenter-collaborative-study
#12
Philemon K Huang, Chen Jianping, Daniel Vitor Vasconcelos-Santos, Jacqueline Souza Dutra Arruda, Parthopratim Dutta Majumder, Eliza Anthony, Sudha K Ganesh, Jyotirmay Biswas, Ho Su Ling, Stephen C Teoh, Rupesh Agrawal
PURPOSE: To describe clinical findings and outcomes for ocular toxoplasmosis in an international multicenter collaborative study. METHODS: Retrospective analysis of 190 patients diagnosed with ocular toxoplasmosis from three study sites (Brazil, India, and Singapore). RESULTS: There were 93 (48.9%) females with a mean age of 32.8 years. The most common symptoms were isolated blurring of vision (36.8%), followed by blurring of vision with floaters (21...
October 11, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28924434/ruptured-retinal-arterial-macroaneurysm-secondary-to-toxoplasmic-kyrieleis-arteriolitis-a-case-report
#13
Natalie Huang, W Andrew Lee, Sean Rivera, Sandra R Montezuma
PURPOSE: The aim of this report was to describe multimodal ocular imaging findings in a patient who presented with a ruptured retinal arterial macroaneurysm (RAM) associated with toxoplasmic Kyrieleis arteriolitis. METHODS: We report the case of a 64-year-old man with a history of systemic hypertension and dense amblyopia of the left eye who presented with decreased vision and new floaters in the left eye. Color fundus photography, spectral-domain optical coherence tomography, fluorescein angiography, and indocyanine green angiography were used as diagnostic imaging tools...
May 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28879584/adverse-event-profile-of-pyrimethamine-based-therapy-in-toxoplasmosis-a-systematic-review
#14
REVIEW
Ruben R Ben-Harari, Elizabeth Goodwin, Julio Casoy
INTRODUCTION: Approximately a third of the population worldwide is chronically infected with Toxoplasma gondii. Pyrimethamine-based regimens are recommended for the treatment of toxoplasmosis. OBJECTIVE: The aim was to evaluate the safety profile of pyrimethamine-based treatment for the three main Toxoplasma manifestations: toxoplasmic encephalitis (TE), ocular toxoplasmosis, and congenital toxoplasmosis. METHODS: PubMed, Cochrane Library, and Google Scholar databases were searched through August 1, 2016...
December 2017: Drugs in R&D
https://www.readbyqxmd.com/read/28861733/patterns-of-uveitis-in-children-at-the-apex-institute-for-eye-care-in-india-analysis-and-review-of-literature
#15
Brijesh Takkar, Pradeep Venkatesh, Nripen Gaur, Sat Pal Garg, Rajpal Vohra, Supriyo Ghose
AIM: To study patterns of uveitis in Indian children and compare with data sets published earlier in the literature. METHODS: Consecutive patients below 16 years of age presenting to the uvea clinic of a tertiary eye care center were included prospectively through the period of July 2009-August 2013. Children with retinal vasculitis, exogenous endophthalmitis and masquerade syndromes were excluded from analysis. Uveitis was classified as per the nomenclature system adopted by the International Uveitis Study Group...
August 31, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28836673/evaluation-of-gene-expression-levels-for-cytokines-in-ocular-toxoplasmosis
#16
M M Maia, C S Meira-Strejevitch, V L Pereira-Chioccola, D D C de Hippólito, V O Silva, C C Brandão de Mattos, F B Frederico, R C Siqueira, L C de Mattos
This study evaluated levels for mRNA expression of 7 cytokines in ocular toxoplasmosis. Peripheral blood mononuclear cells (PBMC) of patients with ocular toxoplasmosis (OT Group, n = 23) and chronic toxoplasmosis individuals (CHR Group, n = 9) were isolated and stimulated in vitro with T. gondii antigen. Negative controls (NC) were constituted of 7 PBMC samples from individuals seronegative for toxoplasmosis. mRNA expression for cytokines was determined by qPCR. Results showed a significant increase in mRNA levels from antigen stimulated PBMCs derived from OT Group for expressing IL-6 (at P < ...
October 2017: Parasite Immunology
https://www.readbyqxmd.com/read/28769551/intravitreal-aflibercept-for-choroidal-neovascularization-associated-with-chorioretinitis-a-pilot-study
#17
Andrii R Korol, Oleksandra Zborovska, Taras Kustryn, Oleksandra Dorokhova, Nataliya Pasyechnikova
PURPOSE: The purpose of this study was to evaluate the potential benefits of intravitreal aflibercept injections for the treatment of choroidal neovascularization (CNV) secondary to chorioretinitis. METHODS: In this uncontrolled, prospective cohort study, 15 eyes of 14 consecutive patients affected by CNV associated with ocular toxoplasmosis were treated with intravitreal aflibercept (2 mg) pro re nata and observed over a 12-month follow-up period. The primary outcome was the change in best-corrected visual acuity (BCVA) from baseline to month 12...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28761461/pcr-based-diagnosis-of-toxoplasma-parasite-in-ocular-infections-having-clinical-indications-of-toxoplasmosis
#18
Atieh Farhadi, Ali Haniloo, Asghar Fazaeli, Siamak Moradian, Mehdi Farhadi
BACKGROUND: The diagnosis of ocular toxoplasmosis is mainly based on clinical features. However, ocular fluid testing by PCR may be very helpful for approval or rejection of this etiology. In this study, we utilized a nested-PCR technique, targeting the B1 partial sequence to analyze the aqueous and vitreous samples for evaluating the presence of the Toxoplasma DNA. METHODS: Fifty aqueous or vitreous humor samples were obtained from patients with clinical features of ocular toxoplasmosis admitted to ophthalmology hospitals and clinics in Iran, within 2014...
January 2017: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/28700250/false-negative-toxoplasma-serology-in-an-immunocompromised-patient-with-pcr-positive-ocular-toxoplasmosis
#19
Rehan Rajput, Alastair K Denniston, Philip I Murray
PURPOSE: The authors report a case of a 60-year-old Caucasian male with a background of treated Chronic Lymphocytic Leukaemia (CLL) with secondary hypogammaglobulinaemia present with toxoplasma chorioretinitis and negative serum toxoplasma serology on presentation and on subsequent reactivation. METHODS: Retrospective case notes review with fundal photographs. RESULTS: In this case, on initial presentation and on recurrence, the patient's serum anti-Toxoplasma IgG remained negative...
July 12, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28640004/ocular-lesions-in-congenital-toxoplasmosis-in-santa-isabel-do-iva%C3%A3-paran%C3%A3-brazil
#20
Ana Paula Sanders, Tatiane Dos Santos, Cleusa Kimie Koike Felipe, Maria Lucia Estevão, Caroni Cícero, Fernanda Evangelista, Carlos Alexandre Manrique, Angélica Sayuri Mizutani, Ana Lucia Falavigna-Guilherme
We verified clinical and psychopedagogic aspects of congenital cases with ocular sequelae, 13 years after toxoplasmosis outbreak in Santa Isabel do Ivaí, and current seroprevalence of this zoonosis in pregnant women. Audiologic and ophthalmologic evaluations were performed in congenital cases, in addition to collection of clinical and psychopedagogic data. In pregnant women, current seroprevalence was observed. Among affected teenagers, 2 of 5 are behind in school grade, and 4 of 5 reported learning difficulties, requiring psychopedagogic monitoring, as well as ocular complaints...
September 2017: Pediatric Infectious Disease Journal
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