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toxoplasmosis ocular

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https://www.readbyqxmd.com/read/28329892/ocular-toxoplasmosis-therapy-related-adverse-drug-reactions-and-their-management
#1
M Helfenstein, S Zweifel, D Barthelmes, F Meier, J Fehr, C Böni
Background There are different treatment options for ocular toxoplasmosis (OT). "Classic" therapy consists of pyrimethamine, sulfadiazine and folinic acid combined with systemic steroids and is still widely used. However, potentially severe side effects of this therapy have been reported. The aim of this retrospective study was to evaluate the incidence and types of adverse drug reactions in patients treated for OT. Clinical management of each adverse drug reaction was assessed. Patients and Methods In this retrospective analysis, we reviewed data of patients with OT, who were consecutively examined between December 2011 and December 2015 at the Department of Ophthalmology, University Hospital Zurich...
March 22, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28283010/-effects-of-azithromycin-and-chlorella-vulgaris-treatment-on-certain-cytokine-values-and-nk-cell-activity-in-an-acute-murine-toxoplasmosis-model
#2
Deniz Gözde Çelik Payçu, Özden Büyükbaba Boral
Toxoplasmosis is a common infection with a complicated treatment process. Azithromycin (AZT) is a macrolide antibiotic that can be effectively used in patients with cerebral and ocular toxoplasmosis and has fewer side effects. Chlorella vulgaris (CV), a single-cell green algae that contains nutrients and has various biological effects. CV extract (CVE) has been shown to have protective effects against infections via immune enhancement by increasing the cytotoxicity of NK cells, IL-12 and IFN-γ levels. The aim of this study was to investigate the protective effects of AZT and CV, individually and in combination, against acute toxoplasmosis in mice, and their effects on NK cell cytotoxixity, IL-12, IFN-γ, and IL-2 levels...
January 2017: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/28274286/galectins-expressed-differently-in-genetically-susceptible-c57bl-6-and-resistant-balb-c-mice-during-acute-ocular-toxoplasma-gondii-infection
#3
S-J Chen, Y-X Zhang, S-G Huang, F-L Lu
Ocular toxoplasmosis (OT) caused by Toxoplasma gondii is a major cause of infectious uveitis, however little is known about its immunopathological mechanism. Susceptible C57BL/6 (B6) and resistant BALB/c mice were intravitreally infected with 500 tachyzoites of the RH strain of T. gondii. B6 mice showed more severe ocular pathology and higher parasite loads in the eyes. The levels of galectin (Gal)-9 and its receptors (Tim-3 and CD137), interferon (IFN)-γ, IL-6 and IL-10 were significantly higher in the eyes of B6 mice than those of BALB/c mice; however, the levels of IFN-α and -β were significantly decreased in the eyes and CLNs of B6 mice but significantly increased in BALB/c mice after infection...
March 9, 2017: Parasitology
https://www.readbyqxmd.com/read/28256490/retinal-imaging-with-smartphone
#4
D S Ademola-Popoola, V A Olatunji
BACKGROUND: The use of smartphones for various purposes among health professionals is increasing, especially with the availability of different applications. On account of cost, fundus cameras are not readily available in ophthalmic practice in developing countries. Since smartphones are readily available, easy to use and portable, they may present a cheap alternative in a resource-limited economy. AIM AND OBJECTIVES: to explore the use of smartphone (Blackberry Z-10) for retinal imaging in a resource-limited economy...
March 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28254558/early-serum-biomarker-networks-in-infants-with-distinct-retinochoroidal-lesion-status-of-congenital-toxoplasmosis
#5
Thádia Evelyn de Araújo, Jordana Grazziela Coelho-Dos-Reis, Samantha Ribeiro Béla, Ana Carolina Aguiar Vasconcelos Carneiro, Anderson Silva Machado, Ludmila Melo Cardoso, Ágata Lopes Ribeiro, Michelle Hallais França Dias, Gláucia Manzan Queiroz Andrade, Daniel Vitor Vasconcelos-Santos, José Nélio Januário, Andréa Teixeira-Carvalho, Ricardo Wagner Almeida Vitor, Eloisa Amália Vieira Ferro, Olindo Assis Martins-Filho
The present study characterized the early changes in the serum chemokines/cytokine signatures and networks in infants with congenital-toxoplasmosis/(TOXO) as compared to non-infected-controls/(NI). TOXO were subgrouped according to the retinochoroidal lesion status as no-lesion/(NL), active-lesion/(ARL), active/cicatricial-lesion/(ACRL) and cicatricial-lesion/(CRL). The results showed that TOXO display prominent chemokine production mediated by IL-8/CXCL8, MIG/CXCL9, IP-10/CXCL10 and RANTES/CCL5. Additionally, TOXO is accompanied by mixed proinflammatory/regulatory cytokine pattern mediated by IL-6, IFN-γ, IL-4, IL-5 and IL-10...
February 28, 2017: Cytokine
https://www.readbyqxmd.com/read/28248682/causes-of-visual-impairment-in-patients-with-ocular-toxoplasmosis
#6
Nedime Şahinoğlu Keşkek, Fikret Ünal, Selim Cevher, Şakir Özgür Keşkek
INTRODUCTION: The aim of this study was to report the causes of visual impairment in patients with the classic clinical presentation of ocular toxoplasmosis (OT). METHODOLOGY: Eight patients with OT underwent standardized ophthalmologic examination and fundus imaging. Macula and the lesions that could be visualized were evaluated by spectral domain optical coherence tomography (SOCT) at presentation. The scan acquisition protocols for SOCT included a radial line scan through the retinochoroiditis lesion, radial line macular scan, and horizontal volume scans at the macula...
February 28, 2017: Journal of Infection in Developing Countries
https://www.readbyqxmd.com/read/28224388/ocular-safety-of-intravitreal-clindamycin-hydrochloride-released-by-plga-implants
#7
Gabriella M Fernandes-Cunha, Silvia Ligório Fialho, Gisele Rodrigues da Silva, Armando Silva-Cunha, Min Zhao, Francine Behar-Cohen
BACKGROUND: Drug ocular toxicity is a field that requires attention. Clindamycin has been injected intravitreally to treat ocular toxoplasmosis, the most common cause of eye posterior segment infection worldwide. However, little is known about the toxicity of clindamycin to ocular tissues. We have previously showed non intraocular toxicity in rabbit eyes of poly(lactic-co-glycolic acid) (PLGA) implants containing clindamycin hydrochloride (CLH) using only clinical macroscotopic observation...
February 21, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28214536/t-cell-immunoregulation-in-active-ocular-toxoplasmosis
#8
Cynthia A Cordeiro, Erica L M Vieira, Vinicius M Castro, Walderez O Dutra, Rogerio A Costa, Juliana L Orefice, Wesley R Campos, Fernando Orefice, Lucy H Young, Antonio Lucio Teixeira
Toxoplasma gondii infection is an important cause of infectious ocular disease. The physiopathology of retinochoroidal lesions associated with this infection is not completely understood. The present study was undertaken to investigate cytokine production by T cells from individuals with active toxoplasmic retinochoroiditis (TR) comparing with controls. Eighteen patients with active TR and 15 healthy controls (6 controls IgG(+) to Toxoplasma and 9 negative controls) were included in the study. Peripheral blood mononuclear cells were incubated in the presence or absence of T...
February 16, 2017: Immunology Letters
https://www.readbyqxmd.com/read/28201950/uveitis-as-an-initial-manifestation-of-acquired-immunodeficiency-syndrome
#9
Chui-Lien Tsen, Shih-Chou Chen, Yao-Shen Chen, Shwu-Jiuan Sheu
Human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) is a multisystem disease that can involve the human eyes. Using ophthalmic examination records from January 2006 to November 2015, we retrospectively reviewed all patients who were diagnosed with HIV/AIDS in our hospital. The study was performed at a tertiary referral center in southern Taiwan. Data included age, gender, ophthalmic examinations, systemic conditions, CD4 cell counts, course, and treatment. Eleven patients were identified as having AIDS with uveitis as their presenting manifestation...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28127354/dna-amplification-techniques-for-the-detection-of-toxoplasma-gondii-tissue-cysts-in-meat-producing-animals-a-narrative-review-article
#10
REVIEW
Farooq Riaz, Imran Rashid, Haroon Akbar, Wasim Shehzad, Saher Islam, Amna Arshad Bajwa, Khalid Saeed, Kamran Ashraf
BACKGROUND: Toxoplasma gondii is an intracellular parasite, which infects one-third population of world. Humans and animals acquire infection by ingesting oocytes from feces of cats or by meat of other animals having cysts that may lead to congenital, ocular or cephalic toxoplasmosis. Either it is important to detect T. gondii from meat of food animals from retail shops or directly at slaughterhouses, which is meant for export. METHODS: The current research was done without time limitation using such terms as follows: "Toxoplasma gondii", "Meat", "Tissue cyst", "PCR", "LAMP", "Screening" and "Immunological assay" alone or in combination, in English language...
October 2016: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/28127336/genotyping-of-toxoplasma-gondii-strains-isolated-from-patients-with-ocular-toxoplasmosis-in-iran
#11
Maryam Norouzi, Seyyed Javad Seyyed Tabaei, Maryam Niyyati, Vafa Saber, Hamed Behniafar
BACKGROUND: Toxoplasma gondii is an obligate, intracellular protozoon that develops its sexual stage in cat's intestinal epithelial cells as definitive host and develops its asexual stage in different tissues of a wide range hosts called intermediate host. The protozoon is a food-borne and worldwide parasite that can cause serious complications such as abortion in pregnant women, encephalitis, and ocular toxoplasmosis. The present study aimed to genotype T. gondii strains isolated from patients with toxoplasmic retinochoroiditis...
July 2016: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/28125765/corticosteroids-as-adjuvant-therapy-for-ocular-toxoplasmosis
#12
REVIEW
Smitha Jasper, Satyanarayana S Vedula, Sheeja S John, Saban Horo, Yasir J Sepah, Quan Dong Nguyen
BACKGROUND: Ocular infection caused by Toxoplasma gondii, a parasite, may result in inflammation in the retina, choroid, and uvea, and consequently lead to complications such as glaucoma, cataract, and posterior synechiae. OBJECTIVES: The objective of this systematic review was to assess the effects of adjunctive use of corticosteroids to anti-parasitic therapy versus anti-parasitic therapy alone for ocular toxoplasmosis. SEARCH METHODS: We searched CENTRAL (which contains the Cochrane Eyes and Vision Trials Register (2016; Issue 11)), MEDLINE Ovid, Epub Ahead of Print, In-Process & Other Non-Indexed Citations, MEDLINE Ovid Daily (January 1946 to December 2016), Embase (January 1980 to December 2016), Latin American and Caribbean Literature on Health Sciences (LILACS (January 1982 to December 2016)), the ISRCTN registry (www...
January 26, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27999640/toxoplasmosis-in-iran-a-guide-for-general-physicians-working-in-the-iranian-health-network-setting-a-systematic-review
#13
REVIEW
Seyed Mohammad Alavi, Leila Alavi
BACKGROUND: Human toxoplasmosis is an important zoonotic infection worldwide which is caused by the intracellular parasite Toxoplasma gondii (T.gondii). The aim of this study was to review briefly the general aspects of toxoplasma infection in in Iranian health system network. METHODS: We searched published toxoplasmosis related articles in English databases including Science Direct, Pub Med, Scopus, Google Scholar, Magiran, Iran Medex, Iran Doc and Scientific Information Database (SID) for toxoplasmosis...
2016: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/27958200/update-on-pathology-of-ocular-parasitic-disease
#14
REVIEW
Dipankar Das, Varsha Ramachandra, Saidul Islam, Harsha Bhattacharjee, Jyotirmay Biswas, Akanksha Koul, Panna Deka, Apurba Deka
Parasites are a group of eukaryotic organisms that may be free-living or form a symbiotic or parasitic relationship with the hosts. Consisting of over 800,000 recognized species, parasites may be unicellular (Protozoa) or multicellular (helminths and arthropods). The association of parasites with human population started long before the emergence of civilization. Parasitic zoonotic diseases are prevalent worldwide including India. Appropriate epidemiological data are lacking on existing zoonotic parasitic diseases, and newer diseases are emerging in our scenario...
November 2016: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/27956093/late-diagnosis-of-congenital-toxoplasmosis-based-on-serological-follow-up-a-case-report
#15
Céline Dard, Cathy Chemla, Hélène Fricker-Hidalgo, Marie-Pierre Brenier-Pinchart, Marie Baret, Alexandre Mzabi, Isabelle Villena, Hervé Pelloux
Toxoplasma gondii is a protozoan parasite infecting up to one third of the world's population. T. gondii infection is usually benign in immunocompetent patients but can be life-threatening when congenitally transmitted. Congenital toxoplasmosis presentation ranges from severe central nervous system and ocular features, to a well appearing newborn with onset of complications late in childhood. The diagnosis of subclinical form remains important since early treatment reduces later complications such as chorioretinitis...
April 2017: Parasitology International
https://www.readbyqxmd.com/read/27925851/epidemiology-of-uveitis-caused-by-htlv-1-toxoplasmosis-and-tuberculosis-the-three-leading-causes-of-endemic-infectious-uveitis-in-japan
#16
Atsunobu Takeda, Tatsuro Ishibashi, Koh-Hei Sonoda
Ethnicity, geography, and socioeconomic factors are among the aspects influencing the prevalence of uveitis in specific areas and countries. Human T-lymphotropic virus type 1-associated uveitis and ocular toxoplasmosis are endemic to Southern Kyushu, the southern-most region of Japan. Recent reports have postulated that the prevalence of intraocular tuberculosis is increasing in Tokyo. This review focuses on local factors that affect the three major vectors for infectious endemic uveitis in Japan, as well as their routes of transmission and factors for improving diagnoses...
December 7, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27901620/etiology-and-clinical-features-of-ocular-inflammatory-diseases-in-a-tertiary-referral-centre-in-sydney-australia
#17
Sophia L Zagora, Richard Symes, Aaron Yeung, Will Yates, Denis Wakefield, Peter J McCluskey
PURPOSE: To report the pattern of uveitis in patients attending a tertiary uveitis service in Sydney, Australia. METHODS: The charts of patients seen between January 2009 and December 2015 were retrospectively reviewed. Data pertaining to patient demographics, eye examination on presentation, work-up and final diagnoses were collected. RESULTS: The total number of patients with uveitis seen over this period was 1165. There were 650 males (56%) and 515 females (44%)...
November 30, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27892751/decline-in-ocular-toxoplasmosis-over-40-years-at-a-tertiary-referral-practice-in-the-united-states
#18
Joshua H Hou, Sarju S Patel, Asim V Farooq, Asad A Qadir, Howard H Tessler, Debra A Goldstein
PURPOSE: To identify whether there has been a decline in ocular toxoplasmosis at a tertiary uveitis practice. METHODS: Retrospective review of new patients at the University of Illinois Uveitis Service from 1973 to 2012. RESULTS: There were 6820 patients with adequate records for inclusion; 323 (4.7%) were diagnosed with ocular toxoplasmosis. There was a 78.0% decline in prevalence of ocular toxoplasmosis from 2008 to 2012 compared with 1973 to 1977...
November 28, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27827450/ocular-toxoplasmosis-susceptibility-in-respect-to-the-genes-encoding-the-kir-receptors-and-their-hla-class-i-ligands
#19
Christiane Maria Ayo, Fábio Batista Frederico, Rubens Camargo Siqueira, Cinara de Cássia Brandão de Mattos, Mariana Previato, Amanda Pires Barbosa, Fernando Henrique Antunes Murata, Aparecida Perpétuo Silveira-Carvalho, Luiz Carlos de Mattos
The objective of this study was to investigate the influence of the genes encoding the KIR receptors and their HLA ligands in the susceptibility of ocular toxoplasmosis. A total of 297 patients serologically-diagnosed with toxoplasmosis were selected and stratified according to the presence (n = 148) or absence (n = 149) of ocular scars/lesions due to toxoplasmosis. The group of patients with scars/lesions was further subdivided into two groups according to the type of ocular manifestation observed: primary (n = 120) or recurrent (n = 28)...
November 9, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27741079/bipolar-disorder-with-psychotic-features-and-ocular-toxoplasmosis-a-possible-pathogenetic-role-of-the-parasite
#20
Claudia Del Grande, Carlo Contini, Elisa Schiavi, Grazia Rutigliano, Martina Maritati, Silva Seraceni, Barbara Pinto, Liliana Dell'Osso, Fabrizio Bruschi
Recent evidence suggests the involvement of Toxoplasma gondii infection in the emergence of psychotic and affective disorders. In this report, we describe the case of a young Brazilian woman affected by recurrent ocular toxoplasmosis and presenting with a manic episode with psychotic features in the context of a diagnosis of Bipolar Disorder (BD), type I. We observed a relationship between ocular manifestations and the clinical course of bipolar illness, confirmed by molecular analyses (nested-PCR), as well as by the high level of T...
March 2017: Journal of Nervous and Mental Disease
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