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toxoplasmosis ocular

Claudia Del Grande, Carlo Contini, Elisa Schiavi, Grazia Rutigliano, Martina Maritati, Silva Seraceni, Barbara Pinto, Liliana Dell'Osso, Fabrizio Bruschi
Recent evidence suggests the involvement of Toxoplasma gondii infection in the emergence of psychotic and affective disorders. In this report, we describe the case of a young Brazilian woman affected by recurrent ocular toxoplasmosis and presenting with a manic episode with psychotic features in the context of a diagnosis of Bipolar Disorder (BD), type I. We observed a relationship between ocular manifestations and the clinical course of bipolar illness, confirmed by molecular analyses (nested-PCR), as well as by the high level of T...
October 12, 2016: Journal of Nervous and Mental Disease
O Villard, B Cimon, C L'Ollivier, H Fricker-Hidalgo, N Godineau, S Houze, L Paris, H Pelloux, I Villena, E Candolfi
Toxoplasmosis, a benign infection, is asymptomatic or pauci-symptomatic in over 80% of cases, excepting immunocompetent patients suffering from ocular toxoplasmosis, as well as immunocompromised patients with opportunistic or congenital toxoplasmosis. Diagnosis is mainly based on serology testing. We thus compared the performance of the nine most commonly-used commercial automated or semi-automated immunoassays for IgG and IgM T. gondii antibody detection: Advia Centaur®, Architect®, AxSYM®, Elecsys®, Enzygnost®, Liaison®, Platelia®, VIDAS®, and VIDIA® assays...
October 12, 2016: Journal of Clinical Microbiology
Cem Ozgonul, Cagri Giray Besirli
Ocular toxoplasmosis, a chorioretinal infection with Toxoplasma gondii, is the most common etiology of posterior uveitis in many countries. Accurate diagnosis depends heavily on the characteristic clinical features of this disease, but atypical presentations, especially in immunocompromised patients, may create diagnostic challenges and lead to misdiagnosis and inappropriate treatment. Molecular biology techniques to diagnose ocular toxoplasmosis have been available for many years and are now accessible as standard laboratory tests in many countries...
October 11, 2016: Ophthalmic Research
Maharan Kabha, Snir Dekalo, Sophie Barnes, Ishay Mintz, Haim Matzkin, Mario Sofer
Background: Obstructive nephropathy is an uncommon side effect of sulfadiazine, which is used for the treatment of toxoplasmosis. We present a case of acute renal colic and urine extravasation of a patient shortly after she was started on this medication. Case Presentation: A 31-year-old female presented with acute renal colic 2 weeks after starting treatment with sulfadiazine and pyrimethamine for ocular toxoplasmosis. Results: A noncontrast computed tomography revealed left hydronephrosis and fluid located around the kidney and in the left gutter...
2016: J Endourol Case Rep
Fábio Barreto Morais, Tiago Eugênio Faria E Arantes, Cristina Muccioli
PURPOSE: To describe treatment practices for ocular toxoplasmosis among members of the Brazilian Uveitis Society. METHODS: An online questionnaire sent to specialists, between October 2014 and March 2015. RESULTS: Most respondents (67.9%) treat all active cases. Most specialists consider visual acuity <20/200 (88.2%), severe vitreous inflammation (94.1%), and ocular disease during acquired infection (88.2%) as absolute indications for treatment...
September 6, 2016: Ocular Immunology and Inflammation
Aaron Wong, James McKelvie, Carol Slight, Joanne Sims
PURPOSE: To investigate the patterns of uveitis at a tertiary referral center in New Zealand. METHODS: Retrospective data were collected for 1260 patients presenting to uveitis clinics in Auckland, New Zealand, between January 2008 and April 2014. Demographics, disease characteristics, and uveitis subtype were analyzed for all patients. RESULTS: Among 1148 patients, 70.3% had anterior uveitis. The most common diagnosis causing anterior uveitis was HLA B27-associated disease...
August 18, 2016: Ocular Immunology and Inflammation
G J Webb, H Shah, M D David, S Tiew, N Beare, G M Hirschfield
Toxoplasmosis may be transferred by organ transplantation. The most common clinical presentation is with multisystem disease, although isolated ocular toxoplasmosis has been described. Many centers have suggested that universal use of co-trimoxazole prophylaxis obviates the need for specific Toxoplasma testing. We report a case of donor-acquired ocular toxoplasmosis after liver transplantation despite co-trimoxazole prophylaxis. The diagnosis was confirmed by Toxoplasma polymerase chain reaction assay in conjunction with seroconversion...
October 2016: Transplant Infectious Disease: An Official Journal of the Transplantation Society
Fatih Mehmet Türkcü, Alparslan Şahin, Harun Yüksel, Yasin Çınar, Kürşat Cingü, Suat Altındağ, Özcan Deveci, Zeynep Özkurt, İhsan Çaça
The purpose of this study was to evaluate patients with activation of toxoplasma retinochoroiditis during pregnancy and ocular findings in newborns. A total of 17 pregnant patients who were clinically and serologically diagnosed with ocular toxoplasmosis were retrospectively reviewed. After birth, ocular findings for all infants were recorded. The mean age of the patients was 29.08 ± 5.71 years. In all cases, activation was present in only one eye. In 13 cases, anterior uveitis was associated with posterior uveitis...
August 1, 2016: International Ophthalmology
F Nilüfer Yalçındağ, Pınar C Özdal, Yılmaz Özyazgan, Figen Batıoğlu, Ilknur Tugal-Tutkun
PURPOSE: To describe the demographic and clinical profiles of uveitis patients seen at secondary and tertiary care centers in Turkey. METHODS: A nationwide web-based registry of patients with uveitis was initiated in November 2008. We analyzed data from a single baseline registry-enrollment visit. RESULTS: In 33 centers, 6967 eyes of 4863 consecutive patients were registered. The mean age at presentation was 36.6 ± 15.7 (1-92) years; 51.3% were male...
July 28, 2016: Ocular Immunology and Inflammation
Jacqueline Martins de Sousa, Heloisa Nascimento, Rubens Belfort
Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rare and potentially fatal adverse drug reaction associated with skin rash, fever, eosinophilia, and multiple organ injury. A number of pharmacological agents are known to cause DRESS syndrome such as allopurinol, anticonvulsants, vancomycin, trimethoprime-sulfamethoxazole, and pyrimethamine-sulfadiazine. Here, we describe two patients who developed DRESS syndrome during ocular treatment. The first case was being treated for late postoperative endophthalmitis with topical antibiotics, intravenous cephalothin, meropenem, and intravitreal injection of vancomycin and ceftazidime before symptoms developed...
May 2016: Arquivos Brasileiros de Oftalmologia
Fabio Bom Aggio, Fernando José de Novelli, Evandro Luis Rosa, Mário Junqueira Nobrega
A 22-year-old man complained of low visual acuity and pain in his left eye for five days. His ophthalmological examination revealed 2+ anterior chamber reaction and a white, poorly defined retinal lesion at the proximal portion of the inferotemporal vascular arcade. There were retinal hemorrhages in the inferotemporal region extending to the retinal periphery. In addition, venous dilation, increased tortuosity, and ischemic retinal whitening along the inferotemporal vascular arcade were also observed. A proper systemic work-up was performed, and the patient was diagnosed with ocular toxoplasmosis...
May 2016: Arquivos Brasileiros de Oftalmologia
Carolina Fernández, Jesús Jaimes, María Camila Ortiz, Juan David Ramírez
No abstract text is available yet for this article.
October 2016: Infection, Genetics and Evolution
Fadoua Zahir, Meriem Abdellaoui, Samar Younes, Idriss A Benatiya, Hicham Tahri
Retinochoroiditis is the most common ocular manifestation of congenital toxoplasmosis, but other associated ophthalmological pathologies can also occur. Ophthalmologists are rarely able to distinguish between toxoplasmic retinochoroiditis due to infection acquired before or after birth, unless other clinical or serological indications are present. This article reports a case of a 3-year-old boy with abnormalities suggestive of congenital toxoplasmosis. The clinical and complementary examinations are discussed...
2015: Pan African Medical Journal
Monika Modrzejewska, Jacek Patalan, Urszula Kulik, Maria Beata Czeszyńska
The aim of this case report was to present extremely severe, ophthalmic complications in form of rare, congenital toxoplasmatic bilateral defect of eye-balls concomitant with advanced uveitis, microphthalmia and eye-multistructural developmental abnormalities leading to irreversible visual disability. The ocular diagnosis was confirmed in Ret-Cam II and ultrasonography and it was accompanied with congenital multiorgan lesions including hepato-splenomegaly, thrombocytopenia, leukomalacia, hydrocephalus and ventriculomegaly with neurological symptoms...
2016: Ginekologia Polska
Camila V Ventura, Mauricio Maia, Simone B Travassos, Thayze T Martins, Felipe Patriota, Marcos Eugênio Nunes, Cristiana Agra, Virginia L Torres, Vanessa van der Linden, Regina C Ramos, Maria Ângela W Rocha, Paula S Silva, Liana O Ventura, Rubens Belfort
IMPORTANCE: The Zika virus (ZIKV) might cause microcephaly and ophthalmoscopic findings in infants of mothers infected during pregnancy. OBJECTIVE: To assess and identify possible risk factors for ophthalmoscopic findings in infants born with microcephaly and a presumed clinical diagnosis of ZIKV intrauterine infection. DESIGN, SETTING, AND PARTICIPANTS: We conducted a cross-sectional study at the Altino Ventura Foundation in Recife, Brazil, that included 40 infants with microcephaly born in Pernambuco state, Brazil, between May and December 2015...
August 1, 2016: JAMA Ophthalmology
Jitender P Dubey, Leandra R Ferreira, Mohammad Alsaad, Shiv K Verma, Derron A Alves, Gary N Holland, Glenn A McConkey
BACKGROUND: The protozoan parasite Toxoplasma gondii is one of the most widely distributed and successful parasites. Toxoplasma gondii alters rodent behavior such that infected rodents reverse their fear of cat odor, and indeed are attracted rather than repelled by feline urine. The location of the parasite encysted in the brain may influence this behavior. However, most studies are based on the highly susceptible rodent, the mouse. METHODOLOGY/PRINCIPAL FINDINGS: Latent toxoplasmosis was induced in rats (10 rats per T...
2016: PloS One
Ukamaka Celestina Fuh, Afekhide E Omoti, Malachi E Enock
PURPOSE: To determine the clinical features and risk factors of presumed ocular toxoplasmosis (POT) in patients affected with the condition at Irrua, Nigeria. METHODS: The study included 69 patients with POT, and 69 age and sex matched subjects who served as the control group. Data was obtained using interviewer administered questionnaires. Examination included measurement of visual acuity (VA), intraocular pressure (IOP), slit lamp examination, gonioscopy and dilated fundus examination...
January 2016: Journal of Ophthalmic & Vision Research
Florence Robert-Gangneux, Sorya Belaz
PURPOSE OF REVIEW: Toxoplasmosis in immunocompromised patients is associated with a high mortality rate. Molecular techniques are important tools to diagnose acute disease in immunocompromised patients, but there are various methods with variable efficiency. Some of them have been validated for the diagnosis of congenital toxoplasmosis, but the impact of their use has not been evaluated in immunocompromised patients. RECENT FINDINGS: Toxoplasmosis is of increasing importance in non-HIV immunocompromised patients...
August 2016: Current Opinion in Infectious Diseases
J G Garweg
INTRODUCTION: Although the seroprevalence of toxoplasmosis has undergone a progressive 50 % decline during the past 20 years, the disease remains an economically important health hazard in many countries. Ocular toxoplasmosis (OT) is the most frequent cause of infectious posterior uveitis, and new insights into its pathophysiology have paved the way for new therapeutic strategies. METHODS: This review summarises recent insights into the disease, its clinical manifestations and therapeutic options...
April 2016: Klinische Monatsblätter Für Augenheilkunde
Ferdinand Dhombres, Stéphanie Friszer, Paul Maurice, Marie Gonzales, François Kieffer, Catherine Garel, Jean-Marie Jouannic
OBJECTIVE: To evaluate the neurodevelopmental and ocular outcome of a continuous retrospective series of fetal toxoplasmosis infections for which prenatal ultrasound (US) follow-up revealed abnormal cerebral findings without associated ventriculomegaly. MATERIALS AND METHODS: We retrospectively reviewed all cases of proven fetal Toxoplasma gondii infection with fetal cerebral anomalies at US examination without significant ventriculomegaly (≥10 mm) evaluated in our center over a 5-year period...
April 20, 2016: Fetal Diagnosis and Therapy
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