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https://www.readbyqxmd.com/read/29788193/ocular-toxoplasmosis-adverse-reactions-to-treatment-in-a-brazilian-cohort
#1
Lusiele Guaraldo, Bianca Balzano de la Fuente Villar, Nicolle Marins Gomes Durão, Virgínia Clare Louro, Marcel de Souza Borges Quintana, André Luiz Land Curi, Elizabeth Souza Neves
Background: The purpose of this study was to estimate the frequency and describe the adverse drug reactions (ADRs) associated with the classic treatment of ocular toxoplasmosis (OT), namely sulfadiazine, pyrimethamine, corticosteroids and folinic acid. Methods: We performed a descriptive study of a prospective cohort of patients with OT treated with the classic therapy. Data were collected during medical consultations and treatment. Results: Of the 147 patients studied, 85% developed one or more ADR...
May 19, 2018: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29779048/increased-il-27-il-27r-expression-in-association-with-the-immunopathology-of-murine-ocular-toxoplasmosis
#2
Xinxin Tong, Shengjie Chen, Huanqin Zheng, Shiguang Huang, Fangli Lu
Interleukin 27 (IL-27) is a member of the IL-6/IL-12 family, and IL-27 receptor (IL-27R) consists of WSX-1 (the IL-27Rα subunit) and the signal-transducing subunit gp130. Human and mouse mast cells (MCs) express the IL-27R. To explore the expressions of IL-27/IL-27R subunits (WSX-1 and gp130) during acute ocular toxoplasmosis (OT), we established mouse model by intraocular injection of 500 Toxoplasma gondii RH strain tachyzoites. Histopathological changes were analyzed, MCs were counted by toluidine blue staining, and tryptase+ /IL-27+ MCs were examined by immunofluorescence double-staining in the eyes and cervical lymph nodes (CLNs) of T...
May 19, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29742869/serologic-tests-of-igg-and-igm-antibodies-and-igg-avidity-for-diagnosis-of-ocular-toxoplasmosis
#3
Bahman Rahimi-Esboei, Mohammad Zarei, Mehdi Mohebali, Hossein Keshavarz Valian, Saeedeh Shojaee, Raziyeh Mahmoudzadeh, Mirataollah Salabati
This prospective study was aimed to detect acute and chronic ocular toxoplasmosis by comparison of anti- Toxoplasma gondii IgM and IgG antibody levels and IgG avidity test. One hundred and seventeen patients with ocular toxoplasmosis (OT) who referred to the Farabi Eye Hospital, Tehran, Iran were included in this study. Of the patients, 77 cases were positive for anti- T. gondii IgG, and 8 cases were positive for anti- T. gondii IgM. IgG avidity test revealed 11, 4, and 102 cases were low, intermediate, and high, respectively, and 6...
April 2018: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/29704469/current-treatment-of-ocular-toxoplasmosis-in-immunocompetent-patients-a-network-meta-analysis
#4
REVIEW
Yanxia Zhang, Xiao Lin, Fangli Lu
Ocular toxoplasmosis (OT) is the most frequent form of infectious posterior uveitis caused by the protozoan parasite Toxoplasma gondii. To evaluate the available evidence in peer-reviewed publications about the most effective therapy for OT in immunocompetent patients, herein a systematic literature search was conducted using Embase, PubMed, Google Scholar, and the Cochrane Central Register of Controlled Trials (CENTRAL) database from January 1987 to October 2017, with search terms "OT", "retinochoroiditis", "treatment", and "immunocompetent"; search filters "controlled clinical trial", "randomized clinical trial", and "clinical trial"...
April 25, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29675078/novel-rab3gap1-mutations-causing-warburg-micro-syndrome-in-two-italian-sisters
#5
Pasquale Loiudice, Debora Napoli, Maria Cristina Ragone, Marco Nardi, Giamberto Casini
This report details two novel RAB3GAP1 mutations causing Warburg Micro syndrome, a rare autosomal recessive disorder characterized by multiple organ abnormalities involving the ocular, nervous, and endocrine systems. Two Italian sisters were referred to our department for the assessment of congenital bilateral cataracts. They also presented with microphthalmia, postnatal microcephaly, severe developmental delay, and hypotony. Perinatal investigations were negative for any toxins or infectious diseases during pregnancy, including toxoplasmosis, rubella, cytomegalovirus, and herpes virus...
October 2017: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/29663900/congenital-toxoplasmosis-in-tunisia-prenatal-and-neonatal-diagnosis-and-postnatal-follow-up-of-35-cases
#6
Boudaouara Yosr, Aoun Karim, Maatoug Rania, Souissi Olfa, Bouratbine Aïda, Ben Abdallah Rym
Congenital toxoplasmosis (CT) results from transplacental passage of Toxoplasma gondii to the fetus during acute maternal infection. Our study aims to report clinical and biological patterns of 35 cases of CT diagnosed at the department of the Parasitology of the Pasteur Institute of Tunis and to access the performance of prenatal and early postnatal diagnosis techniques. Serological screening of maternal infection was performed by Immunoglobulin (Ig) M and IgG detection and IgG avidity determination. Prenatal diagnosis was based on both Toxoplasma DNA detection in the amniotic fluid and monthly ultrasound examinations...
April 16, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29656829/-uveitis-treated-with-biotherapy-and-or-dmard-analysis-from-the-french-pharmacovigilance-study-base
#7
L Cabane, S Baillif, B Baldin, V Breuil, L Euller-Ziegler, N Tieulié
PURPOSE: To report the characteristics of uveitis cases occurring while on biologic therapy or disease-modifying antirheumatic drugs (DMARDs) reported to the French national pharmacovigilance database. METHODS: All the uveitis cases occurring in patients with chronic rheumatologic diseases, chronic inflammatory intestinal diseases or connective tissue diseases, while treated with DMARDs and/or biologic therapies between 2000 and 2015 and reported to the French National Pharmacovigilance Database were collected...
April 13, 2018: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29582812/changing-uveitis-patterns-in-south-india-comparison-between-two-decades
#8
Jyotirmay Biswas, Ranju Kharel Sitaula, Priyansha Multani
Purpose: Changing pattern of uveitis in a subset of a population is an important ocular health indicator. Methods: A comparative study was done between uveitis patients of 2013 and 1995 using two proportions Z-test. Results: In 2013, 352 new uveitis cases were examined. Males 56%, females 44%; unilateral 30.4%; bilateral in 69.6%. A specific diagnosis achieved in 66.2%. Anterior uveitis was seen in 35.22%, intermediate uveitis in 30.11%, posterior uveitis in 25%, and panuveitis in 9...
April 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29513626/diagnostic-value-of-positive-findings-of-toxoplasma-gondii-specific-immunoglobulin-m-serum-antibody-in-uveitis-patients-to-confirm-ocular-toxoplasmosis
#9
Sung Who Park, So Hee Kim, Han Jo Kwon, Seung Min Lee, Ik Soo Byon, Ji Eun Lee
PURPOSE: To assess the value of positive immunoglobulin (Ig) M serum antibody (Ab) findings in uveitis patients. METHODS: We reviewed medical records of patients who had a positive serological test for Toxoplasma gondii-specific IgM Ab. Their clinical data, including history, demographic characteristics, laboratory findings, clinical findings, treatment outcomes, and recurrences, were reviewed retrospectively. RESULTS: Of 2919 uveitis patients who underwent a serological test for suspected ocular toxoplasmosis (OT), 18 presented with positive Ig M results...
March 7, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29473896/congenital-toxoplasmosis-a-plea-for-a-neglected-disease
#10
Martine Wallon, François Peyron
Maternal infection by Toxoplasma gondii during pregnancy may have serious consequences for the fetus, ranging from miscarriage, central nervous system involvement, retinochoroiditis, or subclinical infection at birth with a risk of late onset of ocular diseases. As infection in pregnant women is usually symptomless, the diagnosis relies only on serological tests. Some countries like France and Austria have organized a regular serological testing of pregnant women, some others have no prenatal program of surveillance...
February 23, 2018: Pathogens
https://www.readbyqxmd.com/read/29426041/genetic-polymorphisms-in-cytokine-genes-in-colombian-patients-with-ocular-toxoplasmosis
#11
C A Naranjo-Galvis, A de-la-Torre, L E Mantilla-Muriel, L Beltrán-Angarita, X Elcoroaristizabal-Martín, R McLeod, N Alliey-Rodriguez, I J Begeman, C López de Mesa, J E Gómez-Marín, J C Sepúlveda-Arias
Toxoplasmosis is caused by infection with the protozoan parasite Toxoplasma gondii , which has the capacity to infect all warm-blooded animals worldwide. Toxoplasmosis is a major cause of visual defects in the Colombian population; however, the association between genetic polymorphisms in cytokine genes and susceptibility to ocular toxoplasmosis has not been studied in this population. This work evaluates the associations between polymorphisms in genes coding for the cytokines tumor necrosis factor alpha (TNF-α) (rs1799964, rs1800629, rs1799724, rs1800630, and rs361525), interleukin 1β (IL-1β) (rs16944, rs1143634, and rs1143627), IL-1α (rs1800587), gamma interferon (IFN-γ) (rs2430561), and IL-10 (rs1800896 and rs1800871) and the presence of ocular toxoplasmosis (OT) in a sample of a Colombian population (61 patients with OT and 116 healthy controls)...
April 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29409823/polymerase-chain-reaction-pcr-in-ocular-and-ganglionar-toxoplasmosis-and-the-effect-of-therapeutics-for-prevention-of-ocular-involvement-in-south-american-setting
#12
Jorge Enrique Gómez Marín, Juan David Zuluaga, Eunice Julied Pechené Campo, Jessica Triviño, Alejandra de-la-Torre
INTRODUCTION: Cases of toxoplasmosis present in South America tend to be more severe than that found in other continents. Here, we present our clinical experience of ocular and ganglionar toxoplasmosis in the use of PCR, and of the treatment to prevent ocular involvement. METHODOLOGY: Retrospective analysis of clinical charts of patients with ocular and lymphadenitic toxoplasmosis at the parasitology and tropical medicine consultation in the "Universidad del Quindio" in Colombia...
January 31, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29343531/comparison-of-immunoblotting-iga-and-igg-and-the-goldmann-witmer-coefficient-for-diagnosis-of-ocular-toxoplasmosis-in-immunocompetent-patients
#13
Thibaud Mathis, Sylvain Beccat, Pascal Sève, François Peyron, Martine Wallon, Laurent Kodjikian
BACKGROUND: Ocular toxoplasmosis (OT) is a common cause of posterior uveitis worldwide. The diagnosis of OT is based on clinical findings, but in most cases, laboratory tests are required to confirm the aetiology, especially when other diseases are suspected. The aim of this study was to evaluate which methods, between the Goldmann-Witmer coefficient (GWC) and immunoblotting (IB) with both IgG and IgA, in aqueous humour (AH) samples, can be the most sensitive to diagnose OT, in current practice, especially in the first three weeks...
January 17, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29335806/assessment-of-ocular-toxoplasmosis-patients-reported-at-a-tertiary-center-in-the-northeast-of-iran
#14
Seyedeh Maryam Hosseini, Elham Moghaddas, Karim Sharifi, Malihe Dadgar Moghaddam, Seyed Aliakbar Shamsian
PURPOSE: Ocular toxoplasmosis, which is caused by the single-cell parasite Toxoplasma gondii, is currently the most significant cause of posterior uveitis in the world. No previous studies have described the prevalence and clinical features of ocular toxoplasmosis in the northeast of Iran. The purpose of the current study was to address this gap. METHODS: In this retrospective study, the medical records of 488 uveitis patients who presented to the Khatam-al-Anbia Eye Hospital of Mashhad University of Medical Sciences, a tertiary ophthalmology center in the northeast of Iran, between January 2013 and December 2015 were evaluated...
January 15, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29283732/seroprevalence-and-manifestations-of-ocular-toxoplasmosis-in-patients-with-schizophrenia
#15
Fábio Barreto Morais, Tiago Eugênio Faria E Arantes, Cristina Muccioli
PURPOSE: Recent studies have linked infectious agents such as Toxoplasma gondii to schizophrenia. We investigated the seroprevalence of T. gondii and conducted ophthalmologic examinations in schizophrenia patients and controls to identify lesions suggestive of ocular toxoplasmosis. METHODS: During 2015 and 2016, 34 schizophrenia patients and 85 healthy controls underwent ophthalmologic examination and anti-T. gondii IgG and IgM antibody measurements by chemiluminescence...
December 28, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29221851/ccr5-chemokine-receptor-gene-polymorphisms-in-ocular-toxoplasmosis
#16
Geraldo M de Faria Junior, Christiane M Ayo, Amanda P de Oliveira, Alessandro G Lopes, Fábio B Frederico, Aparecida P Silveira-Carvalho, Mariana Previato, Amanda P Barbosa, Fernando H A Murata, Gildásio Castello de Almeida Junior, Rubens Camargo Siqueira, Luiz C de Mattos, Cinara C Brandão de Mattos
CC chemokine receptor type 5 (CCR5) is a chemokine receptor that influences the immune response to infectious and parasitic diseases. This study aimed to determine whether the CCR5Δ32 and CCR5 59029 A/G polymorphisms are associated with the development of ocular toxoplasmosis in humans. Patients with positive serology for Toxoplasma gondii were analyzed and grouped as 'with ocular toxoplasmosis' (G1: n=160) or 'without ocular toxoplasmosis' (G2: n=160). A control group (G3) consisted of 160 individuals with negative serology...
February 2018: Acta Tropica
https://www.readbyqxmd.com/read/29197989/direct-genetic-characterization-of-toxoplasma-gondii-from-clinical-samples-from-denmark-not-only-genotypes-ii-and-iii
#17
P Jokelainen, J-B Murat, H V Nielsen
Genetic variation within Toxoplasma gondii can have both clinical and epidemiological significance, while the genotypes circulating in many parts of the world, including the Nordic country Denmark, are still unknown. We genetically characterized T. gondii strains that had been detected in human clinical samples in Denmark in 2011-2016. Samples that had tested positive for T. gondii DNA and had a quantification cycle value <33 were included in this study and subjected to direct genetic characterization of T...
March 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29179785/toxoplasma-gondii-reorganizes-the-host-cell-architecture-during-spontaneous-cyst-formation-in-vitro
#18
T C Paredes-Santos, E S Martins-Duarte, W de Souza, M Attias, R C Vommaro
Toxoplasma gondii is an intracellular protozoan parasite that causes toxoplasmosis, a prevalent infection related to abortion, ocular diseases and encephalitis in immuno-compromised individuals. In the untreatable (and life-long) chronic stage of toxoplasmosis, parasitophorous vacuoles (PVs, containing T. gondii tachyzoites) transform into tissue cysts, containing slow-dividing bradyzoite forms. While acute-stage infection with tachyzoites involves global rearrangement of the host cell cytoplasm, focused on favouring tachyzoite replication, the cytoplasmic architecture of cells infected with cysts had not been described...
November 28, 2017: Parasitology
https://www.readbyqxmd.com/read/29177397/-not-everything-is-zika-congenital-toxoplasmosis-still-prevalent-in-colombia
#19
Jorge L Alvarado-Socarras, Keyla Meneses-Silvera, Andrea Carolina Zarate-Vergara, Carlos Guerrero-Gomez, Alfonso J Rodriguez-Morales
Congenital toxoplasmosis continues to be a public health threat. Even existing guidelines, publicly known, its implementation and lack of appropriate interpretation of serological tests in pregnancy is often observed. This leds to failure in opportunities for positive and known interventions to decrease the fetal risk due to Toxoplasma gondii infection. We reported herein a case series, with variable neurological and systemic compromise (respiratory distress, hepatosplenomegaly, enterocolitis, brain calcifications, thrombocytopenia, ascites, shock), even fatal, calling for awareness about the fact that despite the Zika epidemics in 2015-2016 in Brazil, Colombia and other countries, precisely toxoplasmosis, is a differential diagnosis still prevalent in these territories, that can leds to severe consequences, with neurological disability and risk of ocular damage, even lately...
April 2017: Revista Peruana de Medicina Experimental y Salud Pública
https://www.readbyqxmd.com/read/29155634/how-does-imaging-of-congenital-zika-compare-with-imaging-of-other-torch-infections
#20
REVIEW
Deborah Levine, Jacques C Jani, Ilse Castro-Aragon, Mieke Cannie
The acronym TORCH is used to refer to congenital infections, such as toxoplasmosis, other infections (such as syphillis, varicella-zoster, and parvovirus B19), cytomegalovirus, and herpes simplex virus. The classic findings in patients with TORCH infections include rash in the mother during pregnancy and ocular findings in the newborn. Zika virus has emerged as an important worldwide congenital infection. It fits well with other congenital TORCH infections since there is a rash in the mother and there are commonly ocular abnormalities in the newborn...
December 2017: Radiology
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