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https://www.readbyqxmd.com/read/28749592/porphyrin-antennas-on-carbon-nanodots-excited-state-energy-and-electron-transduction
#1
Maurizio Prato, Francesca Arcudi, Volker Strauss, Luka Dordevic, Alejandro Cadranel, Dirk Guldi
We report the synthesis and electron donor-acceptor features of a novel nano-hybrid, in which the light harvesting and electron donating properties of a meso-tetraarylporphyrin (TArP) are combined with the electron accepting features of Nitrogen-Doped Carbon Nanodots (NCNDs). In particular, in a ultrafast process (> 1012 s-1), visible light excitation transforms the strongly quenched porphyrin singlet excited states into 225 ps lived charge separated states. On the other hand, ultraviolet light excitation triggers a non-resolvable transduction of singlet excited state energy from the NCNDs to the porphyrins, followed by the same charge separation observed upon visible light excitation...
July 27, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28749471/pre-synaptic-trkb-in-basolateral-amygdala-neurons-mediates-bdnf-signaling-transmission-in-memory-extinction
#2
Yuan Li, Dongdong Wang, Yang Li, Hongxia Chu, Lining Zhang, Ming Hou, Xingyu Jiang, Zheyu Chen, Bo Su, Tao Sun
Brain-derived neurotrophic factor (BDNF) and its high affinity receptor, TrkB, play an essential role in memory extinction. Our previous work has shown that JIP3 (JNK interacted protein 3) mediates anterograde axonal transport of TrkB through the direct binding of its coiled-coil domain 1 (CC1) with TrkB. Here, we constructed a fluorescent CC1 and enhanced green fluorescent protein (EGFP) fused protein, CC1-EGFP, and found that CC1-EGFP could specifically interrupt TrkB anterograde axonal transport and its localization at the pre-synaptic site...
July 27, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28749360/multi-hypergraph-learning-for-incomplete-multi-modality-data
#3
Mingxia Liu, Yue Gao, Pew-Thian Yap, Dinggang Shen
Multi-modality data convey complementary information that can be used to improve the accuracy of prediction models in disease diagnosis. However, effectively integrating multi-modality data remains a challenging problem especially when the data are incomplete. For instance, more than half of the subjects in the Alzheimer's Disease Neuroimaging Initiative (ADNI) database have no fluorodeoxyglucose positron emission tomography (FDG-PET) and cerebrospinal fluid (CSF) data. Currently, there are two commonly-used strategies to handle the problem of incomplete data: 1) discard samples having missing features, and 2) impute those missing values via specific techniques...
July 26, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28749132/universal-ratiometric-photoelectrochemical-bioassay-with-target-nucleotide-transduction-amplification-and-electron-transfer-tunneling-distance-regulation-strategies-for-ultrasensitive-determination-of-microrna-in-cells
#4
Yingning Zheng, Wenbin Liang, Chengyi Xiong, Ying Zhuo, Yaqin Chai, Ruo Yuan
A universal ratiometric photoelectrochemical (PEC) bioassay, which could be readily expanded for untrasensitive determination of various targets in complex biological matrix, was established by coupling a target-nucleotide transduction-amplification with DNA nanomachine mediated electron-transfer tunneling distance regulation strategies. With the help of target-nucleotide transduction-amplification strategy, the one input target signal could be transducted to corresponding multiple output DNA signals by nucleotide specific recognition technology, simultaneously leading to an efficient signal amplification for target...
July 27, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28748912/a-novel-allosteric-site-in-casein-kinase-2%C3%AE-discovered-using-combining-bioinformatics-and-biochemistry-methods
#5
Hai-Ming Jiang, Jiang-Kai Dong, Kun Song, Tong-Dan Wang, Wen-Kang Huang, Jing-Miao Zhang, Xiu-Yan Yang, Ying Shen, Jian Zhang
Casein kinase 2 (CK2) is a highly pleiotropic serine-threonine kinase, which catalyzed phosphorylation of more than 300 proteins that are implicated in regulation of many cellular functions, such as signal transduction, transcriptional control, apoptosis and the cell cycle. On the other hand, CK2 is abnormally elevated in a variety of tumors, and is considered as a promising therapeutic target. The currently available ATP-competitive CK2 inhibitors, however, lack selectivity, which has impeded their development in cancer therapy...
July 27, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28748759/targeting-kinase-activating-genetic-lesions-to-improve-therapy-of-pediatric-acute-lymphoblastic-leukemia
#6
Franca Raffaella, Natasa Karas Kuzelicki, Claudio Sorio, Eleonora Toffoletti, Oksana Montecchini, Alice Poropat, Marco Rabusin, Debora Curci, Dino Paladin, Gabriele Stocco, Giuliana Decorti
Acute lymphoblastic leukemia (ALL) is the most common hematologic malignancy in children, characterized by an abnormal proliferation of immature lymphoid cells. Thanks to risk-adapted combination chemotherapy treatments currently used, survival at 5 years has reached 90%. ALL is a heterogeneous disease from a genetic point of view: patients' lymphoblasts may harbor in fact several chromosomal alterations, some of which have prognostic and therapeutic value. Of particular importance is the translocation t(9;22)(q34;q11...
July 27, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28748750/chemical-space-of-flt3-inhibitors-as-the-potential-anti-aml-drugs
#7
Qingyuan Lan, Yanle Zhi, Hao Heng, Xiaoxing Guo, Haichun Liu, Yadong Chen, Tao Lu, Shuai Lu
FLT3 is a member of receptor tyrosine kinase III family, expressed in normal bone marrow cells, early progenitor cells and hematopoietic stem cells. The aberrant expression and function of FLT3 are strongly related leukemia, especially acute myeloid leukemia. Its complex amino-acid residues mutations can induce ligand independent activation and downstream signaling transduction, leading to constant proliferation of hematological tumor cells with poor prognosis. Hence FLT3 serves as a promising target in AML chemotherapy...
July 27, 2017: Recent Patents on Anti-cancer Drug Discovery
https://www.readbyqxmd.com/read/28748347/molecular-basis-of-pediatric-brain-tumors
#8
REVIEW
Alexia Klonou, Christina Piperi, Antonios N Gargalionis, Athanasios G Papavassiliou
Brain tumors emerge as the second commonest type of pediatric solid tumors following hematologic malignancies. Genomic profiling of low- and high-grade gliomas, ependymomas and medulloblastomas has revealed chromosomal abnormalities and specific gene mutations which have been associated with aberrant activation of crucial signal transduction pathways, including mitogen-activated protein kinase, mammalian target of rapamycin and retinoblastoma tumor suppressor signaling. Furthermore, pediatric high-grade gliomas are associated with chromatin remodeling defects and somatic histone gene mutations that affect prognosis...
July 26, 2017: Neuromolecular Medicine
https://www.readbyqxmd.com/read/28747957/acn9-regulates-the-inflammatory-responses-in-human-bronchial-epithelial-cells
#9
Jae Hoon Jeong, Jeeyoung Kim, Jeongwoon Kim, Hye-Ryeon Heo, Jin Seon Jeong, Young-Joon Ryu, Yoonki Hong, Seon-Sook Han, Seok-Ho Hong, Seung-Joon Lee, Woo Jin Kim
BACKGROUND: Airway epithelial cells are the first line of defense, against pathogens and environmental pollutants, in the lungs. Cellular stress by cadmium (Cd), resulting in airway inflammation, is assumed to be directly involved in tissue injury, linked to the development of lung cancer, and chronic obstructive pulmonary disease (COPD). We had earlier shown that ACN9 (chromosome 7q21), is a potential candidate gene for COPD, and identified significant interaction with smoking, based on genetic studies...
July 2017: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28747924/endocytosis-of-atrgs1-is-regulated-by-the-autophagy-pathway-after-d-glucose-stimulation
#10
Quanquan Yan, Jingchun Wang, Zheng Qing Fu, Wenli Chen
Sugar, as a signal molecule, has significant functions in signal transduction in which the seven-transmembrane regulator of G-protein signaling (RGS1) protein participates. D-Glucose causes endocytosis of the AtRGS1, leading to the physical uncoupling of AtRGS1 from AtGPA1 and thus a release of the GAP activity and concomitant sustained activation of G-protein signaling. Autophagy involves in massive degradation and recycling of cytoplasmic components to survive environmental stresses. The function of autophagy in AtRGS1 endocytosis during D-glucose stimulation has not been elucidated...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28747899/the-global-redox-responding-regb-rega-signal-transduction-system-regulates-the-genes-involved-in-ferrous-iron-and-inorganic-sulfur-compound-oxidation-of-the-acidophilic-acidithiobacillus-ferrooxidans
#11
Danielle Moinier, Deborah Byrne, Agnès Amouric, Violaine Bonnefoy
The chemical attack of ore by ferric iron and/or sulfuric acid releases valuable metals. The products of these reactions are recycled by iron and sulfur oxidizing microorganisms. These acidophilic chemolithotrophic prokaryotes, among which Acidithiobacillus ferrooxidans, grow at the expense of the energy released from the oxidation of ferrous iron and/or inorganic sulfur compounds (ISCs). In At. ferrooxidans, it has been shown that the expression of the genes encoding the proteins involved in these respiratory pathways is dependent on the electron donor and that the genes involved in iron oxidation are expressed before those responsible for ISCs oxidation when both iron and sulfur are present...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28747780/novel-strategies-to-mimic-transmembrane-tumor-necrosis-factor-dependent-activation-of-tumor-necrosis-factor-receptor-2
#12
Roman Fischer, Jessica Marsal, Cristiano Guttà, Stephan A Eisler, Nathalie Peters, John R Bethea, Klaus Pfizenmaier, Roland E Kontermann
Tumor necrosis factor receptor 2 (TNFR2) is known to mediate immune suppression and tissue regeneration. Interestingly, the transmembrane form of tumor necrosis factor (tmTNF) is necessary to robustly activate TNFR2. To characterize the stoichiometry and composition of tmTNF during TNFR2 activation, we constructed differently oligomerized single chain TNF ligands (scTNF) comprised of three TNF homology domain (THD) protomers that mimic tmTNF. Using a variety of cellular and in vivo assays, we can show that higher oligomerization of the scTNF trimers results in more efficient TNF/TNFR2 clustering and subsequent signal transduction...
July 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28747638/puma-gene-delivery-to-synoviocytes-reduces-inflammation-and-degeneration-of-arthritic-joints
#13
Saw-See Hong, Hubert Marotte, Guillaume Courbon, Gary S Firestein, Pierre Boulanger, Pierre Miossec
In rheumatoid arthritis (RA), the proliferation of fibroblast-like synoviocytes (FLS) is the cause of chronic inflammation in joints and of joint damage. Delivery of the pro-apoptotic gene PUMA to FLS via human adenovirus type 5 (HAdV5) vectors has been tested as a therapeutic approach, but efficiency is hampered by low transduction, as FLS do not express HAdV5 receptors on the cell surface. Here we show that efficient transduction of PUMA in FLS can be achieved by conjugating HAdV5 to a baculovirus, which binds to the cell surface via the envelope glycoprotein Gp64...
July 27, 2017: Nature Communications
https://www.readbyqxmd.com/read/28747547/cross-talk-between-p21-activated-kinase-4-and-er%C3%AE-signaling-triggers-endometrial-cancer-cell-proliferation
#14
Tao Su, Jun-Jie Qu, Kai Wang, Bi-Lan Li, Dong Zhao, Yi-Ping Zhu, Lei Ye, Wen Lu, Xiao-Ping Wan
Cross-talk between estrogen receptor alpha (ERα) and signal transduction pathways plays an important role in the progression of endometrial cancer (EC). Here, we show that 17β-estradiol (E2) stimulation increases p21-activated kinase 4 (Pak4) expression and activation in ER-positive EC cells. The estrogen-induced Pak4 activation is mediated via the PI3K/AKT pathway. Estrogen increases Pak4 and phosphorylated-Pak4 (p-Pak4) nuclear accumulation, and Pak4 in turn enhances ERα trans-activation. Depletion or functional inhibition of Pak4 abrogates EC cell proliferation induced by E2, whereas overexpression of Pak4 rescues cell proliferation decreased by inhibiting the estrogen pathway...
July 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28747251/serca-control-of-cell-death-and-survival
#15
REVIEW
Elie R Chemaly, Luca Troncone, Djamel Lebeche
Intracellular calcium (Ca(2+)) is a critical coordinator of various aspects of cellular physiology. It is increasingly apparent that changes in cellular Ca(2+) dynamics contribute to the regulation of normal and pathological signal transduction that controls cell growth and survival. Aberrant perturbations in Ca(2+) homeostasis have been implicated in a range of pathological conditions, such as cardiovascular diseases, diabetes, tumorigenesis and steatosis hepatitis. Intracellular Ca(2+) concentrations are therefore tightly regulated by a number of Ca(2+) handling enzymes, proteins, channels and transporters located in the plasma membrane and in Ca(2+) storage organelles, which work in concert to fine tune a temporally and spatially precise Ca(2+) signal...
July 12, 2017: Cell Calcium
https://www.readbyqxmd.com/read/28746897/parkinsonian-features-in-aging-gfap-hmox1-transgenic-mice-overexpressing-human-ho-1-in-the-astroglial-compartment
#16
Wei Song, Marisa Cressatti, Hillel Zukor, Adrienne Liberman, Carmela Galindez, Hyman M Schipper
Epigenetic influences mediating brain iron deposition, oxidative mitochondrial injury, and macroautophagy in Parkinson disease and related conditions remain enigmatic. Here, we show that selective overexpression of the stress protein, heme oxygenase-1 (HO-1) in astrocytes of GFAP.HMOX1 transgenic mice between 8.5 and 19 months of age results in nigrostriatal hypodopaminergia associated with locomotor incoordination and stereotypy; downregulation of tyrosine hydroxylase, DAT, LMX1B, Nurr1, Pitx3 and DJ-1 mRNA and/or protein; overproduction of α-synuclein and ubiquitin; oxidative stress; basal ganglia siderosis; mitochondrial damage/mitophagy; and augmented GABAergic systems (increased GABA, GAD67 and reelin)...
June 28, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28746336/discovery-of-novel-brain-permeable-and-g-protein-biased-beta-1-adrenergic-receptor-partial-agonists-for-the-treatment-of-neurocognitive-disorders
#17
Bitna Yi, Alam Jahangir, Andrew K Evans, Denise Briggs, Kristine Ravina, Jacqueline Ernest, Amir B Farimani, Wenchao Sun, Jayakumar Rajadas, Michael Green, Evan N Feinberg, Vijay S Pande, Mehrdad Shamloo
The beta-1 adrenergic receptor (ADRB1) is a promising therapeutic target intrinsically involved in the cognitive deficits and pathological features associated with Alzheimer's disease (AD). Evidence indicates that ADRB1 plays an important role in regulating neuroinflammatory processes, and activation of ADRB1 may produce neuroprotective effects in neuroinflammatory diseases. Novel small molecule modulators of ADRB1, engineered to be highly brain permeable and functionally selective for the G protein with partial agonistic activity, could have tremendous value both as pharmacological tools and potential lead molecules for further preclinical development...
2017: PloS One
https://www.readbyqxmd.com/read/28746304/complex-cellular-logic-computation-using-ribocomputing-devices
#18
Alexander A Green, Jongmin Kim, Duo Ma, Pamela A Silver, James J Collins, Peng Yin
Synthetic biology aims to develop engineering-driven approaches to the programming of cellular functions that could yield transformative technologies. Synthetic gene circuits that combine DNA, protein, and RNA components have demonstrated a range of functions such as bistability, oscillation, feedback, and logic capabilities. However, it remains challenging to scale up these circuits owing to the limited number of designable, orthogonal, high-performance parts, the empirical and often tedious composition rules, and the requirements for substantial resources for encoding and operation...
July 26, 2017: Nature
https://www.readbyqxmd.com/read/28745885/chemical-synthesis-demonstrates-dynamic-o-glycosylation-regulates-folding-and-functional-conformation-of-a-pivotal-egf12-domain-of-human-notch1-receptor
#19
Shun Hayakawa, Yasuhiro Yokoi, Hiroshi Hinou, Shin-Ichiro Nishimura
The interaction of human NOTCH1 receptor and its ligands is a crucial step to initiate the intracellular signal transductions, in which O-glycosylation of the extracellular EGF-like domain is known to modify this pathway that strongly affects multiple aspects of cell differentiation, development, and cancer biology. In spite of the emerging importance of O-glycosylation in the NOTCH signaling pathway, consequences of this dynamic O-glycosylation processes in ER/Golgi on the folding of functional EGF-like domains re-main unclear...
July 26, 2017: Biochemistry
https://www.readbyqxmd.com/read/28745865/electroactive-biofilms-for-sensing-reflections-and-perspectives
#20
Antonin Prévoteau, Korneel Rabaey
Microbial electrochemistry has from the onset been recognized for its sensing potential due to the microbial ability to enhance signals through metabolic cascades, its relative selectivity toward substrates, and the higher stability conferred by the microbial ability to self-replicate. The greatest challenge has been to achieve stable and efficient transduction between a microorganism and an electrode surface. Over the past decades, a new kind of microbial architecture has been observed to spontaneously develop on polarized electrodes: the electroactive biofilm (EAB)...
July 26, 2017: ACS Sensors
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