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https://www.readbyqxmd.com/read/29149663/%C3%AE-keto-tetrahydrofuran-lignan-glucosides-from-the-bangladeshi-medicinal-plant-terminalia-citrina-inhibit-estradiol-e2-induced-proliferation-in-cancer-cells
#1
Md Abdul Muhit, Kaoru Umehara, Hiroshi Noguchi
EtOAc extract from the leaves of Terminalia citrina collected in Bangladesh were separated, and seven previously undescribed α-keto tetrahydrofuran lignan glucosides (terminalosides Q to W) were isolated and characterized. NOESY analysis of (1)H NMR spectra and ECD spectroscopic data analysis revealed the absolute stereochemistry of the tetrahydrofuran ring of the isolated constituents as being a (7S,8R,8'S)- configuration in terminalosides Q to U and a (7R,8R,8'S)- configuration in terminalosides V and W...
November 14, 2017: Phytochemistry
https://www.readbyqxmd.com/read/29115385/schisandrin-a-suppresses-lipopolysaccharide-induced-inflammation-and-oxidative-stress-in-raw-264-7-macrophages-by-suppressing-the-nf-%C3%AE%C2%BAb-mapks-and-pi3k-akt-pathways-and-activating-nrf2-ho-1-signaling
#2
Da Hye Kwon, Hee-Jae Cha, Eun Ok Choi, Sun-Hee Leem, Gi-Young Kim, Sung-Kwon Moon, Young-Chae Chang, Seok-Joong Yun, Hye Jin Hwang, Byung Woo Kim, Wun-Jae Kim, Yung Hyun Choi
Schisandrin A is a bioactive lignan occurring in the fruits of plants of the Schisandra genus that have traditionally been used in Korea for treating various inflammatory diseases. Although the anti-inflammatory and antioxidant effects of lignan analogues similar to schisandrin A have been reported, the underlying molecular mechanisms have remained elusive. In the present study, schisandrin A significantly suppressed the lipopolysaccharide (LPS)-induced production of the key pro-inflammatory mediators nitric oxide (NO) and prostaglandin E2 by suppressing the expression of inducible NO synthase and cyclooxygenase-2 at the mRNA and protein levels in RAW 264...
October 25, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29104539/annonaceae-breaking-the-wall-of-inflammation
#3
REVIEW
Ali Attiq, Juriyati Jalil, Khairana Husain
Inventories of tropical forests have listed Annonaceae as one of the most diverse plant families. For centuries, it is employed in traditional medicines to cure various pathological conditions including snakebite, analgesic, astringent, diarrhea, dysentery, arthritis pain, rheumatism, neuralgia, and weight loss etc. Phytochemical analysis of Annonaceae family have reported the occurrence of alkaloids, flavonoids, triterpenes, diterpenes and diterpene flavone glycosides, sterols, lignans, and annonaceous acetogenin characteristically affiliated with Annonaceae sp...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29054705/cistanches-herba-an-overview-of-its-chemistry-pharmacology-and-pharmacokinetics-property
#4
REVIEW
Zhifei Fu, Xiang Fan, Xiaoying Wang, Xiumei Gao
ETHNOPHARMACOLOGICAL RELEVANCE: Cistanches Herba is an Orobanchaceae parasitic plant. As a commonly used Traditional Chinese Medicine (TCM), its traditional functions include treating kidney deficiency, impotence, female infertility and senile constipation. Chemical analysis of Cistanches Herba revealed that phenylethanoid glycosides, iridoids, lignans, oligosaccharides, and polysaccharides were the main constituents. Pharmacological studies demonstrated that Cistanches Herba exhibited neuroprotective, immunomodulatory, hormonal balancing, anti-fatigue, anti-inflammatory, hepatoprotection, anti-oxidative, anti-bacterial, anti-viral, and anti-tumor effects, etc...
October 17, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29046352/the-lignan-manassantin-is-a-potent-and-specific-inhibitor-of-mitochondrial-complex-i-and-bioenergetic-activity-in-mammals
#5
Yibao Ma, Hae-Ki Min, Unsong Oh, Adam M Hawkridge, Wei Wang, Ahmed A Mohsin, Qun Chen, Arun Sanyal, Edward J Lesnefsky, Xianjun Fang
Dineolignans manassantin A and B from the plant Saururus cernuus are used in traditional medicine to manage a wide range of ailments such as edema, jaundice, and gonorrhea. Cell-based studies have identified several molecular target candidates of manassantin including NF-kappaB, MAPK, STAT3 and hypoxia-inducible factor 1 alpha (HIF-1alpha). It is unclear whether or how these structurally diverse proteins or pathways mediate any of the medical benefits of manassantin in vivo. Moreover, it has been recently reported that manassantin causes developmental arrest in zebrafish by inhibiting the mitochondrial complex I, but it is unknown whether manassantin inhibits mitochondrial respiration in intact mammalian cells and live animals...
October 18, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28990509/potential-of-plant-sourced-phenols-for-inflammatory-bowel-disease
#6
Hai-Tao Xiao, Bo Wen, Xiang-Chun Shen, Zhao-Xiang Bian
Inflammatory bowel disease (IBD) is an uncontrolled chronic inflammatory intestinal disorder, which requires medications for long-term therapy. Facing the challenges of severe side effects and drug resistance of conventional medications, to develop the strategies meet the stringent safety and effectiveness in the long-term treatment are urgent in the clinics. In this regard, a growing body of evidence confirms plant-sourced phenols, such as flavonoids, catechins, stilbenes, coumarins, quinones, lignans, phenylethanoids, cannabinoid phenols, tannins, phenolic acids and hydroxyphenols, exert potent protective benefits with fewer undesirable effects in conditions of acute or chronic intestinal inflammation through improvement of colonic oxidative and pro-inflammatory status, preservation of the epithelial barrier function and modulation of gut microbiota...
October 9, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28990504/polyphenols-in-food-cancer-prevention-and-apoptosis-induction
#7
Ashita Sharma, Mandeep Kaur, Jatinder Kaur Katnoria, Avinash Kaur Nagpal
Polyphenols are group of water-soluble organic compounds, mainly of natural origin. The compounds having about 5-7 aromatic rings and more than 12 phenolic hydroxyl groups are classified as polyphenols. These are the antioxidants which protect the body from oxidative damage. In plants, they are the secondary metabolites produced as a defense mechanism against stress factors. Antioxidant property of polyphenols is suggested to provide protection against many diseases associated with reactive oxygen species (ROS), including cancer...
October 6, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28978677/rye-bran-modified-with-cell-wall-degrading-enzymes-influences-the-kinetics-of-plant-lignans-but-not-of-enterolignans-in-multicatheterized-pigs
#8
Anne K Bolvig, Natalja P Nørskov, Sophie van Vliet, Leslie Foldager, Mihai V Curtasu, Mette S Hedemann, Jens F Sørensen, Helle N Lærke, Knud E Bach Knudsen
Background: Whole-grain intake is associated with a lower risk of chronic Western-style diseases, possibly brought about by the high concentration of phytochemicals, among them plant lignans (PLs), in the grains.Objective: We studied whether treatment of rye bran with cell wall-degrading enzymes changed the solubility and kinetics of PLs in multicatheterized pigs.Methods: Ten female Duroc × Danish Landrace × Yorkshire pigs (60.3 ± 2.3 kg at surgery) fitted with permanent catheters were included in an incomplete crossover study...
October 4, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28951214/arctigenin-represses-tgf-%C3%AE-induced-epithelial-mesenchymal-transition-in-human-lung-cancer-cells
#9
Yanrui Xu, Zhiyuan Lou, Seong-Ho Lee
Arctigenin (ARC) is a lignan that is abundant in Asteraceae plants, which show anti-inflammatory and anti-cancer activities. The current study investigated whether ARC affects cancer progression and metastasis, focusing on EMT using invasive human non-small cell lung cancer (NSCLC) cells. No toxicity was observed in the cells treated with different doses of ARC (12-100 μM). The treatment of ARC repressed TGF-β-stimulated changes of metastatic morphology and cell invasion and migration. ARC inhibited TGF-β-induced phosphorylation and transcriptional activity of smad2/3, and expression of snail...
November 18, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28938521/beneficial-health-applications-and-medicinal-values-of-pedicularis-plants-a-review
#10
REVIEW
Mohd Iqbal Yatoo, Umesh Dimri, Arumugam Gopalakrishnan, Kumaragurubaran Karthik, Marappan Gopi, Rekha Khandia, Mani Saminathan, Archana Saxena, Mahmoud Alagawany, Mayada Ragab Farag, Ashok Munjal, Kuldeep Dhama
Pedicularis plants (Orobanchaceae), popularly known as lousewort, are found in Asia, Europe, and North America, and have been used in Sowa-Rigpa, the Himalayan art of healing and a traditional system of medicine for treating various ailments in humans. A comprehensive compilation on this valuable medicinal plant is not available, however. The present extensive review provides insight into the salient medicinal properties of Pedicularis plants with respect to various health issues and diseases. Our previous studies on Pedicularis plants from the Changthang region of Ladakh (India) and research advances leading to new developments in this field have prompted this review...
November 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28936846/-lignans-from-barks-of-ailanthus-altissima
#11
Dong Liu, Jian Zhang, Shao-Nan Tang, Xiao-Qi Zhang, Wen-Cai Ye
Eleven lignans were isolated from the ethanol extract of the barks of Ailanthus altissima through various column chromatography methods including silica gel, Sephadex LH-20, ODS and HPLC. By physical, chemical and comprehensive spectroscopic methods, their structures were identified as (+)-neoolivil(1), prunustosanan AI (2), (7S,8R)-guaiacyl-glycerol-β-O-4'-neolignan (3), (7R,8S)-guaiacyl-glycerol-β-O-4'-neolignan (4), (7S,8R)-1-(4-hydroxy-3-methoxyphenyl)-2-[4-(3-hydroxypropyl)-2,6-dimethoxyphenoxy]-1,3-propanediol(5), pinnatifidanin B V (6), pinnatifidanin B VI (7), (7R,7'R,7″S,8S,8'S,8″S)-4',4″-dihydroxy-3,3',3″,5-tetramethoxy-7,9':7',9-diepoxy-4,8″-oxy-8,8'-sesquineolignan-7″,9″-diol (8), hedyotol D (9), 5-(2-propenyl)-7-methoxy-2-(3,4-methylenediovxyphenyl)benzofuran (10), and (7R,8S,7'E)-guaiacyl-glycerol-β-O-4'-sinapyl ether(11)...
December 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28934153/inhibitory-effect-of-selaginellins-from-selaginella-tamariscina-beauv-spring-against-cytochrome-p450-and-uridine-5-diphosphoglucuronosyltransferase-isoforms-on-human-liver-microsomes
#12
Jae-Kyung Heo, Phi-Hung Nguyen, Won Cheol Kim, Nguyen Minh Phuc, Kwang-Hyeon Liu
Selaginella tamariscina (Beauv.) has been used for traditional herbal medicine for treatment of cancer, hepatitis, and diabetes in the Orient. Numerous bioactive compounds including alkaloids, flavonoids, lignans, and selaginellins have been identified in this medicinal plant. Among them, selaginellins having a quinone methide unit and an alkylphenol moiety have been known to possess anticancer, antidiabetic, and neuroprotective activity. Although there have been studies on the biological activities of selaginellins, their modulatory potential of cytochrome P450 (P450) and uridine 5'-diphosphoglucuronosyltransferase (UGT) activities have not been previously evaluated...
September 21, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28925005/simultaneous-qualitative-and-quantitative-analyses-of-triterpenoids-in-ilex-pubescens-by-ultra-high-performance-liquid-chromatography-coupled-with-quadrupole-time-of-flight-mass-spectrometry
#13
Di Cao, Qing Wang, Jing Jin, Maosong Qiu, Lian Zhou, Xinghong Zhou, Hui Li, Zhongxiang Zhao
INTRODUCTION: Ilex pubescens Hook et Arn mainly contains triterpenoids that possess antithrombotic, anti-inflammatory and analgesic effects. Quantitative and qualitative analyses of the triterpenoids in I. pubescens can be useful for determining the authenticity and quality of raw materials and guiding its clinical preparation. OBJECTIVES: To establish a method for rapid and comprehensive analysis of triterpenoids in I. pubescens using ultra-high-performance liquid chromatography coupled to electrospray ionisation and quadrupole time-of-flight-mass spectrometry (UPLC-ESI-QTOF-MS), which will also be applied to evaluate the contents of nine triterpenoids among root, root heartwood and root bark of I...
September 18, 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28895237/a-comprehensive-characterisation-of-rosemary-tea-obtained-from-rosmarinus-officinalis-l-collected-in-a-sub-humid-area-of-tunisia
#14
Mariem Achour, Raquel Mateos, Maha Ben Fredj, Ali Mtiraoui, Laura Bravo, Saad Saguem
INTRODUCTION: Rosemary (Rosmarinus officinalis L.) is an aromatic plant common in Tunisia and it is widely consumed as a tea in traditional cuisine and in folk medicine to treat various illnesses. Currently, most research efforts have been focused on rosemary essential oil, alcoholic and aqueous extracts, however, little is reported on rosemary infusion composition. OBJECTIVE: To investigate compounds present in rosemary tea obtained from Rosmarinus officinalis L...
September 12, 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28884079/podophyllotoxin-a-novel-potential-natural-anticancer-agent
#15
REVIEW
Hamidreza Ardalani, Amir Avan, Majid Ghayour-Mobarhan
OBJECTIVE: The aim of the present review is to give an overview about the role, biosynthesis, and characteristics of Podophyllotoxin (PTOX) as a potential antitumor agent with particular emphasis on key biosynthesis processes, function of related enzymes and characterization of genes encoding the enzymes. MATERIALS AND METHODS: Google scholar, PubMed and Scopus were searched for literatures which have studied identification, characterization, fermentation and therapeutic effects of PTOX and published in English language until end of 2016...
July 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/28863384/therapeutical-strategies-for-anxiety-and-anxiety-like-disorders-using-plant-derived-natural-compounds-and-plant-extracts
#16
REVIEW
Julia Fedotova, Peter Kubatka, Dietrich Büsselberg, Alexander G Shleikin, Martin Caprnda, Jozef Dragasek, Luis Rodrigo, Miroslav Pohanka, Iveta Gasparova, Vladimir Nosal, Radka Opatrilova, Tawar Qaradakhi, Anthony Zulli, Peter Kruzliak
Anxiety and anxiety-like disorders describe many mental disorders, yet fear is a common overwhelming symptom often leading to depression. Currently two basic strategies are discussed to treat anxiety: pharmacotherapy or psychotherapy. In the pharmacotherapeutical clinical approach, several conventional synthetic anxiolytic drugs are being used with several adverse effects. Therefore, studies to find suitable safe medicines from natural sources are being sought by researchers. The results of a plethora experimental studies demonstrated that dietary phytochemicals like alkaloids, terpenes, flavonoids, phenolic acids, lignans, cinnamates, and saponins or various plant extracts with the mixture of different phytochemicals possess anxiolytic effects in a wide range of animal models of anxiety...
November 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28862686/identification-of-polar-constituents-in-the-decoction-of-juglans-mandshurica-and-in-the-medicated-egg-prepared-with-the-decoction-by-hplc-q-tof-ms%C3%A2
#17
Tian-Min Wang, Ying Fu, Wen-Jie Yu, Chen Chen, Xue Di, Hui Zhang, Yan-Jun Zhai, Zheng-Yun Chu, Ting-Guo Kang, Hu-Biao Chen
As a folk medicinal plant, Juglans mandshurica has been used for the treatment of cancer in China and Korea. Traditionally, J. mandshurica is decocted together with chicken eggs. Both the decoction and medicated eggs possess anti-tumor properties. Clarifying the constituents of the decoction and absorbed by the medicated eggs is essential for the investigation of the active principles of J. mandshurica. Herein, the medicated eggs were prepared by decocting raw chicken eggs, having unbroken shells, with the decoction of J...
September 1, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28839377/flavones-and-lignans-from-the-stems-of-wikstroemia-scytophylla-diels
#18
Jie-Ping Lei, Juan-Juan Yuan, Sheng-Hao Pi, Rui Wang, Rui Tan, Chao-Ying Ma, Tao Zhang, He-Zhong Jiang
BACKGROUND: The genus Wikstroemia has about 70 species, but only a limited number of species have been studied chemically. Wikstroemia indica has long been used as a traditional crude drug in China. However, there is no report about the bioactivity of Wikstroemia scytophylla. OBJECTIVE: This paper reports the chemical investigation and biological evaluation of the W. scytophylla. MATERIALS AND METHODS: The EtOAc extraction of W. scytophylla was isolated using chromatographic methods, and the compounds were analyzed by spectroscopic methods...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28837110/phytochemistry-pharmacology-and-traditional-uses-of-plants-from-the-genus-trachelospermum-l
#19
REVIEW
Zefeng Zhao, Xirui He, Yuhui Zhao, Ying Sun, Xufei Chen, Ye Cun, Linhong Huang, Yajun Bai, Xiaohui Zheng
This paper is intended to review advances in the botanical, phytochemical, traditional uses and pharmacological studies of the genus Trachelospermum. Until now, 138 chemical constituents have been isolated and characterized from these plants, particularly from T. asiaticum and T. jasminoides. Among these compounds, lignans, triterpenoids, and flavonoids are the major bioactive constituents. Studies have shown that plants from the genus Trachelospermum exhibit an extensive range of pharmacological properties both in vivo and in vitro, including anti-inflammatory, analgesic, antitumor, antiviral and antibacterial activities...
August 24, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28808723/plasma-metabolite-abundances-are-associated-with-urinary-enterolactone-excretion-in-healthy-participants-on-controlled-diets
#20
Fayth L Miles, Sandi L Navarro, Yvonne Schwarz, Haiwei Gu, Danijel Djukovic, Timothy W Randolph, Ali Shojaie, Mario Kratz, Meredith A J Hullar, Paul D Lampe, Marian L Neuhouser, Daniel Raftery, Johanna W Lampe
Enterolignans, products of gut bacterial metabolism of plant lignans, have been associated with reduced risk of chronic diseases, but their association with other plasma metabolites is unknown. We examined plasma metabolite profiles according to urinary enterolignan excretion in a cross-sectional analysis using data from a randomized crossover, controlled feeding study. Eighty healthy adult males and females completed two 28-day feeding periods differing by glycemic load, refined carbohydrate, and fiber content...
September 20, 2017: Food & Function
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