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https://www.readbyqxmd.com/read/28512713/matairesinol-suppresses-neuroinflammation-and-migration-associated-with-src-and-erk1-2-nf-%C3%AE%C2%BAb-pathway-in-activating-bv2-microglia
#1
Peng Xu, Meng-Wei Huang, Chen-Xi Xiao, Fen Long, Ying Wang, Si-Yu Liu, Wan-Wan Jia, Wei-Jun Wu, Di Yang, Jin-Feng Hu, Xin-Hua Liu, Yi-Zhun Zhu
Chronic neuroinflammation is a pathological feature of neurodegenerative diseases. Inhibition of microglia-mediated neuroinflammation might be a potential strategy for neurodegeneration. Matairesinol, a dibenzylbutyrolactone plant lignan, presents in a wide variety of foodstuffs. It has been found to possess anti-angiogenic, anti-oxidative, anti-cancer and anti-fungal activities. In the present study, we investigated the anti-neuroinflammation effects of matairesinol on lipopolysaccharide (LPS)-induced BV2 microglia cells and the related molecular mechanisms...
May 17, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28501003/phytochemicals-for-taming-agitated-immune-endocrine-neural-axis
#2
REVIEW
Seema Patel
Homeostasis of immune-endocrine-neural axis is paramount for human health. If this axis gets agitated due to age, genetic variations, environmental exposures or lifestyle assaults, a cascade of adverse reactions occurs in human body. Cytokines, hormones and neurotransmitters, the effector molecules of this axis behave erratically, leading to a gamut of neural, endocrine, autoimmune, and metabolic diseases. Current panel of drugs can tackle some of them but not in a sustainable, benign way as a myriad of side effects, causal of them have been documented...
May 10, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28498356/nine-different-chemical-species-and-action-mechanisms-of-pancreatic-lipase-ligands-screened-out-from-forsythia-suspensa-leaves-all-at-one-time
#3
Tinggui Chen, Yayun Li, Liwei Zhang
It is difficult to screen out as many active components as possible from natural plants all at one time. In this study, subfractions of Forsythia suspensa leaves were firstly prepared; then, their inhibitive abilities on pancreatic lipase were tested; finally, the highest inhibiting subfraction was screened by self-made immobilized pancreatic lipase. Results showed that nine ligands, including eight inhibitors and one promotor, were screened out all at one time. They were three flavonoids (rutin, IC50: 149 ± 6...
May 12, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28494583/isolation-identification-and-biological-evaluation-of-phenolic-compounds-from-the-traditional-north-american-confectionery-maple-sugar
#4
Yongqiang Liu, Kenneth Rose, Nicholas Dasilva, Shelby Johnson, Navindra P Seeram
Maple sap, collected from the sugar maple (Acer saccharum) tree, is boiled to produce the popular plant-derived sweetener, maple syrup, which can then be further evaporated to yield the traditional North American confectionery, maple sugar. While maple sap and maple syrup have been previously studied, the phytochemical constituents of maple sugar are unknown. Herein, thirty phenolic compounds, 1-30, primarily lignans, were isolated and identified (by HRESIMS and NMR) from maple sugar. The isolates included the phenylpropanoid-based lignan tetramers, (erythro,erythro)-4'',4'''-dihydroxy-3,3',3'',3''',5,5'-hexamethoxy-7,9';7',9-diepoxy-4,8'';4',8'''-bisoxy-8,8'-dineolignan-7'',7''',9'',9'''-tetraol, 29, and (threo,erythro)-4'',4'''-dihydroxy-3,3',3'',3''',5,5'-hexamethoxy-7,9';7',9-diepoxy-4,8'';4',8'''-bisoxy-8,8'-dineolignan-7'',7''',9'',9'''-tetraol, 30, neither of which have been identified from maple sap or maple syrup before...
May 12, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28487651/mechanism-underlying-the-reversal-of-drug-resistance-in-p-glycoprotein-expressing-leukemia-cells-by-pinoresinol-and-the-study-of-a-derivative
#5
María L González, D Mariano A Vera, Jerónimo Laiolo, Mariana B Joray, Mariana Maccioni, Sara M Palacios, Gabriela Molina, Priscila A Lanza, Samanta Gancedo, Vivian Rumjanek, María C Carpinella
P-glycoprotein (P-gp) is a membrane protein associated with multidrug resistance (MDR) due to its key role in mediating the traffic of chemotherapeutic drugs outside cancer cells, leading to a cellular response that hinders efforts toward successful therapy. With the aim of finding agents that circumvent the MDR phenotype mediated by P-gp, 15 compounds isolated from native and naturalized plants of Argentina were screened. Among these, the non-cytotoxic lignan (±) pinoresinol successfully restored sensitivity to doxorubicin from 7 μM in the P-gp overexpressed human myelogenous leukemia cells, Lucena 1...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28486830/ethnomedicinal-uses-phytochemistry-and-pharmacological-aspects-of-the-genus-premna-a-review
#6
Roza Dianita, Ibrahim Jantan
CONTEXT: The genus Premna (Lamiaceae), distributed throughout tropical and subtropical Asia, Africa, Australia and the Pacific Islands, is used in folk medicine primarily to treat inflammation, immune-related diseases, stomach disorders, wound healing, and skin diseases. OBJECTIVES: This review exhaustively gathers available information on ethnopharmacological uses, phytochemistry, and bioactivity studies on more than 20 species of Premna and critically analyzes the reports to provide the perspectives and directions for future research for the plants as potential source of drug leads and pharmaceutical agents...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28476319/simultaneous-determination-of-components-with-wide-polarity-and-content-ranges-in-cistanche-tubulosa-using-serially-coupled-reverse-phase-hydrophilic-interaction-chromatography-tandem-mass-spectrometry
#7
Yu Yan, Qingqing Song, Xiaojia Chen, Jun Li, Peng Li, Yitao Wang, Tongxiang Liu, Yuelin Song, Pengfei Tu
To meet the demands from plant physiologists and pharmacognosists, sustainable efforts are being devoted by the analytical chemists from all over the world to search an approach being capable of simultaneously monitoring primary along with secondary metabolites. The key technical bottlenecks currently lie at affording satisfactory chromatographic and spectrometric performances for both hydrophilic and hydrophobic substances that span a great content range. Herein, reverse phase liquid chromatography was directly coupled with hydrophilic interaction chromatography, namely RPLC-HILIC, to integrate their merits, whereas dilution pumps were employed to tackle the mismatching for the mobile phase between them...
June 9, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28472349/dirigent-proteins-in-plants-modulating-cell-wall-metabolism-during-abiotic-and-biotic-stress-exposure
#8
Candelas Paniagua, Anna Bilkova, Phil Jackson, Siarhei Dabravolski, Willi Riber, Vojtech Didi, Josef Houser, Nora Gigli-Bisceglia, Michaela Wimmerova, Eva Budinska, Thorsten Hamann, Jan Hejatko
Dirigent (DIR) proteins were found to mediate regio- and stereoselectivity of bimolecular phenoxy radical coupling during lignan biosynthesis. Here we summarize the current knowledge of the importance of DIR proteins in lignan and lignin biosynthesis and highlight their possible importance in plant development. We focus on the still rather enigmatic Arabidopsis DIR gene family, discussing the few members with known functional importance. We comment on recent discoveries describing the detailed structure of two DIR proteins with implications in the mechanism of DIR-mediated catalysis...
May 3, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28459363/arctigenin-induced-gallbladder-cancer-senescence-through-modulating-epidermal-growth-factor-receptor-pathway
#9
Mingdi Zhang, Shizhong Cai, Bin Zuo, Wei Gong, Zhaohui Tang, Di Zhou, Mingzhe Weng, Yiyu Qin, Shouhua Wang, Jun Liu, Fei Ma, Zhiwei Quan
Gallbladder cancer has poor prognosis and limited therapeutic options. Arctigenin, a representative dibenzylbutyrolactone lignan, occurs in a variety of plants. However, the molecular mechanisms involved in the antitumor effect of arctigenin on gallbladder cancer have not been fully elucidated. The expression levels of epidermal growth factor receptor were examined in 100 matched pairs of gallbladder cancer tissues. A positive correlation between high epidermal growth factor receptor expression levels and poor prognosis was observed in gallbladder cancer tissues...
May 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28451749/functional-characterization-of-the-pinoresinol-lariciresinol-reductase-2-gene-reveals-its-roles-in-yatein-biosynthesis-and-flax-defense-response
#10
Cyrielle Corbin, Samantha Drouet, Ivan Mateljak, Lucija Markulin, Cédric Decourtil, Sullivan Renouard, Tatiana Lopez, Joël Doussot, Frédéric Lamblin, Daniel Auguin, Eric Lainé, Elisabeth Fuss, Christophe Hano
This study provides new insights into the biosynthesis regulation and in planta function of the lignan yatein in flax leaves. Pinoresinol-lariciresinol reductases (PLR) catalyze the conversion of pinoresinol into secoisolariciresinol (SECO) in lignan biosynthesis. Several lignans are accumulated in high concentrations, such as SECO accumulated as secoisolariciresinol diglucoside (SDG) in seeds and yatein in aerial parts, in the flax plant (Linum usitatissimum L.) from which two PLR enzymes of opposite enantioselectivity have been isolated...
April 27, 2017: Planta
https://www.readbyqxmd.com/read/28436004/engineering-of-an-h2-o2-auto-scavenging-in-vivo-cascade-for-pinoresinol-production
#11
Yongkun Lv, Xiaozhong Cheng, Guocheng Du, Jingwen Zhou, Jian Chen
Pinoresinol is a natural lignan with a high market value that has potential pharmacological and food supplement applications. Pinoresinol is currently isolated from plants, which suffers from low efficiency and yield. To produce pinoresinol from inexpensive and industrially available eugenol, an in vivo enzymatic cascade composed of vanillyl alcohol oxidase and peroxidase was designed, which scavenges H2 O2 automatically and eliminates protein purification and cofactor addition. Two peroxidases were screened and identified from Escherichia coli BL21 (DE3), and tested in the enzymatic cascade...
April 24, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/28424569/current-knowledge-of-schisandra-chinensis-turcz-baill-chinese-magnolia-vine-as-a-medicinal-plant-species-a-review-on-the-bioactive-components-pharmacological-properties-analytical-and-biotechnological-studies
#12
REVIEW
Agnieszka Szopa, Radosław Ekiert, Halina Ekiert
Schisandra chinensis Turcz. (Baill.) is a plant species whose fruits have been well known in Far Eastern medicine for a long time. However, schisandra seems to be a plant still underestimated in contemporary therapy still in the countries of East Asia. The article presents latest available information on the chemical composition of this plant species. Special attention is given to dibenzo cyclooctadiene lignans. In addition, recent studies of the biological activity of dibenzocyclooctadiene lignans and schisandra fruit extracts are recapitulated...
2017: Phytochemistry Reviews: Proceedings of the Phytochemical Society of Europe
https://www.readbyqxmd.com/read/28401567/arnica-montana-l-a-plant-of-healing-review
#13
REVIEW
Priyanka Kriplani, Kumar Guarve, Uttam S Baghael
OBJECTIVES: Arnica montana is a widely used therapeutic plant used traditionally to treat various ailments. The objective of this study was to evaluate the botany, phytochemistry and ethnopharmacology along with special emphasis given on pharmacological activity of plant A. montana. KEY FINDINGS: The plant extracts have been reported to possess antibacterial, antitumor, antioxidant, anti-inflammatory, antifungal and immunomodulatory activity. A wide range of chemical compounds including sesquiterpene lactones and their short-chain carbonic acid esters, flavonoids, carotenoids, essential oils, diterpenes, arnidiol, pyrrolizidine alkaloids, coumarins, phenolic acids, lignans and oligosaccharides, etc...
April 11, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28323486/enterolactone-induces-g1-phase-cell-cycle-arrest-in-nonsmall-cell-lung-cancer-cells-by-downregulating-cyclins-and-cyclin-dependent-kinases
#14
Shireen Chikara, Kaitlin Lindsey, Harsharan Dhillon, Sujan Mamidi, Jeffrey Kittilson, Melpo Christofidou-Solomidou, Katie M Reindl
Flaxseed is a rich source of the plant lignan secoisolariciresinol diglucoside (SDG), which is metabolized into mammalian lignans enterodiol (ED) and enterolactone (EL) in the digestive tract. The anticancer properties of these lignans have been demonstrated for various cancer types, but have not been studied for lung cancer. In this study, we investigated the anticancer effects of EL for several nonsmall cell lung cancer (NSCLC) cell lines of various genetic backgrounds. EL inhibited the growth of A549, H441, and H520 lung cancer cells in concentration- and time-dependent manners...
May 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28299617/methyl-caffeate-and-some-plant-constituents-inhibit-age-related-inflammation-effects-on-senescence-associated-secretory-phenotype-sasp-formation
#15
Hyun Lim, Byung Kyu Park, Sook Young Shin, Yong Soo Kwon, Hyun Pyo Kim
During aging, cells secrete molecules called senescence-associated secretory phenotype (SASP). They constitute chronic low-grade inflammation environment to adjacent cells and tissues. In order to find inhibiting agents of SASP formation, 113 plant constituents were incubated with BJ fibroblasts for 6 days after treatment with bleomycin. Several plant constituents showed considerable inhibition of IL-6 production, a representative SASP marker. These plant constituents included anthraquinones such as aurantio-obtusin, flavonoids including astragalin, iristectorigenin A, iristectorigenin B, linarin, lignans including lariciresinol 9-O-glucoside and eleutheroside E, phenylpropanoids such as caffeic acid and methyl caffeate, steroid (ophiopogonin), and others like centauroside, rhoifolin and scoparone...
March 15, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/28294620/effect-of-antibiotics-and-diet-on-enterolactone-concentration-and-metabolome-studied-by-targeted-and-nontargeted-lc-ms-metabolomics
#16
Anne K Bolvig, Natalja P Nørskov, Mette S Hedemann, Leslie Foldager, Brendan McCarthy-Sinclair, Maria L Marco, Helle N Lærke, Knud E Bach Knudsen
High plant lignan intake is associated with a number of health benefits, possibly induced by the lignan metabolite enterolactone (ENL). The gut microbiota plays a crucial role in converting dietary lignans into ENL, and epidemiological studies have shown that use of antibiotics is associated with lower levels of ENL. Here we investigate the link between antibiotic use and lignan metabolism in pigs using LC-MS/MS. The effect of lignan intake and antibiotic use on the gut microbial community and the pig metabolome is studied by 16S rRNA sequencing and nontargeted LC-MS...
May 3, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28279068/%C3%AE-catenin-mediates-anti-adipogenic-and-anticancer-effects-of-arctigenin-in-preadipocytes-and-breast-cancer-cells
#17
Jihye Lee, Jee-Young Imm, Seong-Ho Lee
Arctigenin is a lignan abundant in Asteraceae plants and has anti-inflammatory, antiobesity, and anticancer activities. Obesity is one of the leading causes of several types of cancers including breast cancer. The current study was performed to investigate if arctigenin suppresses differentiation of preadipocytes and proliferation of breast cancer cells and to explore potential molecular mechanisms. Treatment of arctigenin reduced lipid accumulation in differentiated 3T3-L1 adipocytes in a dose- and time-dependent manner without toxicity...
March 15, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28275053/inhibiting-clathrin-mediated-endocytosis-of-the-leucine-rich-g-protein-coupled-receptor-5-diminishes-cell-fitness
#18
Joshua C Snyder, Lauren K Rochelle, Caroline Ray, Thomas F Pack, Cheryl B Bock, Veronica Lubkov, H Kim Lyerly, Alan S Waggoner, Larry S Barak, Marc G Caron
The leucine-rich G protein-coupled receptor-5 (LGR5) is expressed in adult tissue stem cells of many epithelia, and its overexpression is negatively correlated with cancer prognosis. LGR5 potentiates WNT/β-catenin signaling through its unique constitutive internalization property that clears negative regulators of the WNT-receptor complex from the membrane. However, both the mechanism and physiological relevance of LGR5 internalization are unclear. Therefore, a natural product library was screened to discover LGR5 internalization inhibitors and gain mechanistic insight into LGR5 internalization...
April 28, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28273165/transcriptome-profiling-of-influenza-a-virus-infected-lung-epithelial-a549-cells-with-lariciresinol-4-%C3%AE-d-glucopyranoside-treatment
#19
Beixian Zhou, Jing Li, Xiaoli Liang, Zifeng Yang, Zhihong Jiang
The influenza A virus is an acute contagious pathogen that affects the human respiratory system and can cause severe lung disease and even death. Lariciresinol-4-β-D-glucopyranoside is a lignan that is extracted from Isatis indigotica, which is a medicinal herb plant that was commonly applied to treat infections, the common cold, fever and inflammatory diseases. Our previous study demonstrated that lariciresinol-4-β-D-glucopyranoside possesses anti-viral and anti-inflammatory properties. However, the comprehensive and detailed mechanisms that underlie the effect of lariciresinol-4-β-D-glucopyranoside interventions against influenza virus infection remain to be elucidated...
2017: PloS One
https://www.readbyqxmd.com/read/28264205/chemical-composition-antiprotozoal-and-cytotoxic-activities-of-indole-alkaloids-and-benzofuran-neolignan-of-aristolochia-cordigera
#20
Marcos D P Pereira, Tito da Silva, Anna Caroline C Aguiar, Glaucius Oliva, Rafael V C Guido, Jenicer K U Yokoyama-Yasunaka, Silvia R B Uliana, Lucia M X Lopes
This is a comparative study on the intraspecific chemical variability of Aristolochia cordigera species, collected in two different regions of Brazil, Biome Cerrado (semiarid) and Biome Amazônia (coastal). The use of GC-MS and statistical methods led to the identification of 56 compounds. A higher percentage of palmitone and germacrene-D in the hexanes extracts of the leaves of plants from these respective biomes was observed. Phytochemical studies on the extracts led to the isolation and identification of 19 known compounds, including lignans, neolignans, aristolochic acids, indole-β-carboline, and indole alkaloids...
March 6, 2017: Planta Medica
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