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https://www.readbyqxmd.com/read/29676099/-binding-interaction-of-harpagoside-and-bovine-serum-albumin-spectroscopic-methodologies-and-molecular-docking
#1
Tuan-Wu Cao, Wen-Bing Huang, Jian-Wei Shi, Wei He
Scrophularia ningpoensis has exhibited a variety of biological activities and been used as a pharmaceutical product for the treatment of inflammatory ailment, rheumatoid arthritis, osteoarthritis and so on. Harpagoside (HAR) is considerer as a main bioactive compound in this plant. Serum albumin has important physiological roles in transportation, distribution and metabolism of many endogenous and exogenous substances in body. It is of great significance to study the interaction mechanism between HAR and bovine serum albumin (BSA)...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29672014/robust-covalently-crosslinked-polybenzimidazole-graphene-oxide-membranes-for-high-flux-organic-solvent-nanofiltration
#2
Fan Fei, Levente Cseri, Gyorgy Szekely, Christopher Francis Blanford
Robust, readily scalable, high-flux graphene oxide (GO) mixed matrix composite membranes were developed for organic solvent nanofiltration. Hydroxylated polybenzimidazole was synthesized by N-benzylation of polybenzimidazole with 4-(chloromethyl)benzyl alcohol, which was confirmed by FTIR and NMR spectroscopy. Flat sheet composite membranes comprising of polybenzimidazoles and 1 or 2 wt% GO were fabricated via conventional blade coating and phase inversion. Subsequently, GO was covalently anchored to the hydroxyl groups of the polymer using a diisocyanate crosslinking agent...
April 19, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29671072/reversion-of-multidrug-resistance-by-co-encapsulation-of-doxorubicin-and-metformin-in-poly-lactide-co-glycolide-d-%C3%AE-tocopheryl-polyethylene-glycol-1000-succinate-nanoparticles
#3
Vahid Shafiei-Irannejad, Nasser Samadi, Roya Salehi, Bahman Yousefi, Mahdi Rahimi, Abolfazl Akbarzadeh, Nosratollah Zarghami
PURPOSE: P-glycoprotein (P-gp) mediated multidrug resistance (MDR) has been recognized as the main obstacle against successful cancer treatment. To address this problem, co-encapsulated doxorubicin (DOX) and metformin (Met) in a biodegradable polymer composed of poly(lactide-co-glycolide) (PLGA) and D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) was prepared. We reported in our previous study that Met inhibits P-gp in DOX resistant breast cancer (MCF-7/DOX) cells. TPGS is a bioactive compound which has also been shown to inhibit P-gp, further to its pharmaceutical advantages...
April 18, 2018: Pharmaceutical Research
https://www.readbyqxmd.com/read/29669995/pharmacokinetic-and-tissue-distribution-of-fucoidan-from-fucus-vesiculosus-after-oral-administration-to-rats
#4
Olga N Pozharitskaya, Alexander N Shikov, Natalya M Faustova, Ekaterina D Obluchinskaya, Vera M Kosman, Heikki Vuorela, Valery G Makarov
Fucus vesiculosus L., known as bladderwrack, belongs to the brown seaweeds, which are widely distributed throughout northern Russia, Atlantic shores of Europe, the Baltic Sea, Greenland, the Azores, the Canary Islands, and shores of the Pacific Ocean. Fucoidan is a major fucose-rich sulfated polysaccharide found in Fucus ( F. ) vesiculosus . The pharmacokinetic profiling of active compounds is essential for drug development and approval. The aim of the study was to evaluate the pharmacokinetics and tissue distribution of fucoidan in rats after a single-dose oral administration...
April 18, 2018: Marine Drugs
https://www.readbyqxmd.com/read/29669674/community-views-on-factors-affecting-medicines-resource-allocation-cross-sectional-survey-of-3080-adults-in-australia
#5
Lesley Chim, Glenn Salkeld, Patrick J Kelly, Wendy Lipworth, Dyfrig A Hughes, Martin R Stockler
Objective The aim of the present study was to determine Australian community views on factors that influence the distribution of health spending in relation to medicines. Methods A cross-sectional web-based survey was performed of 3080 adults aged ≥18 years. Participants were asked to rank, in order of importance, 12 criteria according to which medicines funding decisions may be made. Results Of all respondents, 1213 (39.4%) considered disease severity to be the most important prioritisation criterion for funding a new medicine...
April 19, 2018: Australian Health Review: a Publication of the Australian Hospital Association
https://www.readbyqxmd.com/read/29668215/limited-distribution-networks-stifle-competition-in-the-generic-and-biosimilar-drug-industries
#6
Laura Karas, Kenneth M Shermock, Celia Proctor, Mariana Socal, Gerard F Anderson
A limited distribution network (LDN) restricts the distribution channel for a pharmaceutical drug to 1 or a very small number of distributors. This strategy may allow for more effective allocation of drugs in shortage and is purported to help ensure the safe distribution of high-risk drugs to small patient populations. However, in recent years, some drug companies, including Turing Pharmaceuticals, have used LDNs to prevent generic and biosimilar companies from accessing samples of drug products necessary to perform testing required by the FDA for generic and biosimilar drug applications...
April 1, 2018: American Journal of Managed Care
https://www.readbyqxmd.com/read/29662034/inline-determination-of-residence-time-distribution-in-hot-melt-extrusion
#7
Jens Wesholowski, Andreas Berghaus, Markus Thommes
In the framework of Quality-by-Design (QbD), the inline determination of process parameters or quality attributes of a product using sufficient process analytical technology (PAT) is a center piece for the establishment of continuous processes as a standard pharmaceutical technology. In this context, Twin-Screw-Extrusion (TSE) processes, such as Hot-Melt-Extrusion (HME), are one key aspect of current research. The main benefit of this process technology is the combination of different unit operations. Several of these sub-processes are linked to the Residence Time Distribution (RTD) of the material within the apparatus...
April 15, 2018: Pharmaceutics
https://www.readbyqxmd.com/read/29662024/pkidb-a-curated-annotated-and-updated-database-of-protein-kinase-inhibitors-in-clinical-trials
#8
Fabrice Carles, Stéphane Bourg, Christophe Meyer, Pascal Bonnet
The number of protein kinase inhibitors (PKIs) approved worldwide continues to grow steadily, with 39 drugs approved in the period between 2001 and January 2018. PKIs on the market have been the subject of many reviews, and structure-property relationships specific to this class of drugs have been inferred. However, the large number of PKIs under development is often overlooked. In this paper, we present PKIDB (Protein Kinase Inhibitor Database), a monthly-updated database gathering approved PKIs as well as PKIs currently in clinical trials...
April 15, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29660617/changes-in-bacterial-community-structure-and-antibiotic-resistance-genes-in-soil-in-the-vicinity-of-a-pharmaceutical-factory
#9
Youchao Zhu, Qi Zhang, Jiahui Xu, Qian Qu, Tao Lu, Benben Du, Mingjing Ke, Meng Zhang, Haifeng Qian
China is the largest global producer of antibiotics. With the demand for antibiotics increasing every year, it is necessary to assess potential environmental risks and the spread of antibiotic resistance genes (ARGs) associated with antibiotic production. Here, we investigated the occurrence and distribution of ARGs in soil in the vicinity of a pharmaceutical factory. The results showed that antibiotic concentrations were under the detection limit; however, ARGs were present in soil and tended to be enriched near the factory...
April 13, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29659381/methodological-aspects-for-preclinical-evaluation-of-gadolinium-presence-in-brain-tissue-critical-appraisal-and-suggestions-for-harmonization-a-joint-initiative
#10
Philippe Robert, Thomas Frenzel, Cécile Factor, Gregor Jost, Marlène Rasschaert, Gunnar Schuetz, Nathalie Fretellier, Janina Boyken, Jean-Marc Idée, Hubertus Pietsch
Gadolinium (Gd)-based contrast agents (GBCAs) are pharmaceuticals that have been approved for 30 years and used daily in millions of patients worldwide. Their clinical benefits are indisputable. Recently, unexpected long-term presence of Gd in the brain has been reported by numerous retrospective clinical studies and confirmed in preclinical models particularly after linear GBCA (L-GBCA) compared with macrocyclic GBCA (M-GBCA). Even if no clinical consequences of Gd presence in brain tissue has been demonstrated so far, in-depth investigations on potential toxicological consequences and the fate of Gd in the body remain crucial to potentially adapt the clinical use of GBCAs, as done during the nephrogenic systemic fibrosis crisis...
April 13, 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29658695/pdag-bimetallic-nano-alloy-decorated-graphene-a-nanohybrid-with-unprecedented-electrocatalytic-catalytic-and-sensing-activity
#11
Sajad Ahmad Bhat, Nusrat Rashid, Mudasir Ahmad Rather, Sarwar Ahmad Pandit, Ghulam Mohammad Rather, Pravin P Ingole, Mohsin Ahmad Bhat
The recent reports about the promising and tuneable electrocatalytic activity and stability of nanoalloys have stimulated an intense research activity towards the design and synthesis of homogenously alloyed novel bimetallic nano-electrocatalysts. We, herein present a simple one-pot facile wet-chemical approach for the deposition of high quality bimetallic palladium-silver (PdAg) homogenous nanoalloy crystals on reduced graphene oxide (Gr) sheets. Morphological, structural and chemical characterization of the so crafted nanohybrids establishes a homogeneous distribution of 1:1 PdAg nanoalloy crystals supported over reduced graphene oxide (PdAg-Gr)...
April 16, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29653457/difficulties-in-differentiating-natural-from-synthetic-alkaloids-by-isotope-ratio-monitoring-using-13c-nuclear-magnetic-resonance-spectrometry
#12
Richard J Robins, Katarzyna M Romek, Mathilde Grand, Pierrick Nun, Didier Diomande, Maxime Julien, Gérald S Remaud
Within the food and pharmaceutical industries, there is an increasing legislative requirement for the accurate labeling of the product's origin. A key feature of this is to indicate whether the product is of natural or synthetic origin. With reference to this context, we have investigated three alkaloids commonly exploited for human use: nicotine, atropine, and caffeine. We have measured by 13 C nuclear magnetic resonance spectrometry the position-specific distribution of 13 C at natural abundance within several samples of each of these target molecules...
April 13, 2018: Planta Medica
https://www.readbyqxmd.com/read/29650353/reprint-of-environmental-toxicology-and-omics-a-question-of-sex
#13
Xuefang Liang, April Feswick, Denina Simmons, Christopher J Martyniuk
Molecular initiating events and downstream transcriptional/proteomic responses provide valuable information for adverse outcome pathways, which can be used predict the effects of chemicals on physiological systems. There has been a paucity of research that addresses sex-specific expression profiling in toxicology and due to cost, time, and logistic considerations, sex as a variable has not been widely considered. In response to this deficiency, federal agencies in the United States, Canada, and Europe have highlighted the importance of including sex as a variable in scientific investigations...
April 10, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29650044/human-amnion-derived-mesenchymal-stem-cells-alleviate-lung-injury-induced-by-white-smoke-inhalation-in-rats
#14
Pei Cui, Haiming Xin, Yongming Yao, Shichu Xiao, Feng Zhu, Zhenyu Gong, Zhiping Tang, Qiu Zhan, Wei Qin, Yanhua Lai, Xiaohui Li, Yalin Tong, Zhaofan Xia
BACKGROUND: White smoke inhalation (WSI) is an uncommon but potentially deadly cause of acute lung injury and acute respiratory distress syndrome for which no effective pharmaceutical treatment has been developed. This study aimed to determine the protective effects of human amnion-derived mesenchymal stem cells (hAMSCs) against WSI-induced lung injury in rats. METHODS: hAMSCs were injected into rats via the tail vein 4 h after WSI. At 1, 3, 7, 14, and 28 days after cell injection, hAMSCs labeled with PKH26 in lung, heart, liver, and kidney tissues were observed by fluorescence microscopy...
April 12, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29649530/self-assembled-hyaluronic-acid-nanoparticles-implications-as-a-nanomedicine-for-treatment-of-type-2-diabetes
#15
Jun Gi Rho, Hwa Seung Han, Ji Hye Han, Hansang Lee, Van Quy Nguyen, Wang Hee Lee, Seunglee Kwon, Sungeun Heo, Juhwan Yoon, Han Ho Shin, Eun-Young Lee, Hoin Kang, Siyoung Yang, Eun Kyung Lee, Jae Hyung Park, Wook Kim
Self-assembled hyaluronic acid nanoparticles (HA-NPs) have been extensively investigated for biomedical and pharmaceutical applications owing to their biocompatibility and receptor-binding properties. Here, we report that an empty HA-NP itself not bearing any drug has therapeutic effects on adipose tissue inflammation and insulin resistance. HA-NPs inhibited not only the receptor-mediated internalization of low-molecular-weight (LMW) free HA but also LMW free HA-induced pro-inflammatory gene expression in mouse primary bone marrow-derived macrophages (BMDMs) isolated from wild-type mice, but not in CD44-null (CD44-/-) BMDMs...
April 9, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29649468/probing-the-amorphous-state-of-pharmaceutical-compounds-within-mesoporous-material-using-pair-distribution-function-analysis
#16
Alfonso E Garcia-Bennett, Michael Lau, Nicholas Bedford
Pharmaceutical compounds with poor solubility are loaded within mesoporous materials in order to understand the effect of mesoscale confinement on their dissolution behaviour. Structural and calorimetric characterization is combined with atomic pair distribution function analysis probing the interactions between the silica surface and the loaded amorphous compound. Whilst different degrees of amorphism are not identifiable from X-ray diffraction data or calorimetry techniques, the atomic pair distribution function analysis can help identify local ordering of the drug molecules...
April 9, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29648833/manufacturing-amorphous-solid-dispersions-with-a-tailored-amount-of-crystallized-api-for-biopharmaceutical-testing
#17
Frank Theil, Johanna Milsmann, Sankaran Anantharaman, Holger van Lishaut
The preparation of an amorphous solid dispersion (ASD) by dissolving a poorly water-soluble active pharmaceutical ingredient (API) in a polymer matrix can improve the bioavailability by orders of magnitude. Crystallization of the API in the ASD, though, is an inherent threat for bioavailability. Commonly, the impact of crystalline API on the drug release of the dosage form is studied with samples containing spiked crystallinity. These spiked samples possess implicit differences compared to native crystalline samples, regarding size and spatial distribution of the crystals as well as their molecular environment...
April 12, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29642545/chloroplast-genome-of-the-folk-medicine-and-vegetable-plant-talinum-paniculatum-jacq-gaertn-gene-organization-comparative-and-phylogenetic-analysis
#18
Xia Liu, Yuan Li, Hongyuan Yang, Boyang Zhou
The complete chloroplast (cp) genome of Talinum paniculatum (Caryophyllale), a source of pharmaceutical efficacy similar to ginseng, and a widely distributed and planted edible vegetable, were sequenced and analyzed. The cp genome size of T. paniculatum is 156,929 bp, with a pair of inverted repeats (IRs) of 25,751 bp separated by a large single copy (LSC) region of 86,898 bp and a small single copy (SSC) region of 18,529 bp. The genome contains 83 protein-coding genes, 37 transfer RNA (tRNA) genes, eight ribosomal RNA (rRNA) genes and four pseudogenes...
April 9, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29623710/-development-of-dissolution-method-for-warfarin-sodium-tablets
#19
Ivana Lukášová, Jan Muselík, Aleš Franc
Warfarin is intensively discussed drug with narrow therapeutic index. In the past, its generic substitution was identified as a cause of bleeding. Altered quality of the active substance or varying drug content was discussed. The substance quality can be evaluated with adequate dissolution method. An official dissolution method with aqueous medium exists, however this method is non-discriminatory. In the first 15 minutes the whole amount of the active pharmaceutical ingredient is released from a tested dosage form, which does not allow comparison between tablets from different producers and it also makes difficult to track the changes throughout stability testing...
2018: Ceská a Slovenská Farmacie
https://www.readbyqxmd.com/read/29620538/pharmaceutical-micelles-featured-with-singlet-oxygen-responsive-cargo-release-and-mitochondrial-targeting-for-enhanced-photodynamic-therapy
#20
Xin Zhang, Qi Yan, Di Naer Mulatihan, Jundong Zhu, Aiping Fan, Zheng Wang, Yanjun Zhao
The efficacy of nanoparticulate photodynamic therapy is often compromised by the short life time and limited diffusion radius as well as uncontrolled intracellular distribution of photosensitizer. It was hypothesized that rapid photosensitizer release upon nanoparticle internalization and its preferred accumulation in mitochondria would address the above problems. Hence, the aim of this study was to engineer a multifunctional micellar nanosystem featured with singlet oxygen-responsive cargo release and mitochondria targeting...
April 5, 2018: Nanotechnology
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