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Pharmaceutical distribution

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https://www.readbyqxmd.com/read/28214672/evaluation-of-molecular-chaperone-drug-function-regorafenib-and-%C3%AE-cyclodextrins
#1
Xiurong Hu, Mengying Sun, Yang Li, Guping Tang
Regorafenib (RG) was an oral multi-kinase inhibitor with poor water solubility. In order to enhance the drug's solubility, dissolution and bioavailability, the binary molecular chaperone drug between RG and β-cyclodetrin (β-CD) had prepared by co-crystallization. The structure of RG-β-CD was characterized by thermal analysis, powder X-ray diffraction, infrared spectroscopy and nuclear magnetic resonance. Phase-solubility study revealed the higher solubility and complexing ability of β-CDwith RG.The solubility and dissolution of RG-β-CD was significantly enhanced in pH 1...
February 7, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28209193/up601-a-standardized-botanical-composition-composed-of-morus-alba-yerba-mate-and-magnolia-officinalis-for-weight-loss
#2
Mesfin Yimam, Ping Jiao, Mei Hong, Lidia Brownell, Young-Chul Lee, Eu-Jin Hyun, Hyun-Jin Kim, Jeong-Bum Nam, Mi-Ran Kim, Qi Jia
BACKGROUND: The prevalence of obesity is surging in an alarming rate all over the world. Pharmaceutical drugs are considered potential adjunctive therapy to lifestyle modification. However, for most, besides being too expensive, their long term usages are hindered by their severe adverse effects. Here we describe the effect of UP601, a standardized blend of extracts from Morus alba, Yerba mate and Magnolia officinalis, in modulating a number of obesity-related phenotypic and biochemical markers in a high-fat high-fructose (HFF)-induced C57BL/6J mouse model of obesity...
February 16, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28198558/predictive-framework-for-estimating-exposure-of-birds-to-pharmaceuticals
#3
Thomas G Bean, Kathryn E Arnold, Julie M Lane, Ed Bergström, Jane Thomas-Oates, Barnett A Rattner, Alistair B A Boxall
Here we present and evaluate a framework for estimating concentrations of pharmaceuticals over time in wildlife feeding at wastewater treatment plants (WWTPs). The framework is composed of a series of predictive steps involving the estimation of pharmaceutical concentration in wastewater, accumulation into wildlife food items, uptake by wildlife with subsequent distribution into, and elimination from, tissues. As many pharmacokinetic parameters for wildlife are unavailable for the majority of drugs in use, a read-across approach was employed using either rodent or human data on absorption, distribution, metabolism and excretion (ADME)...
February 15, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28188541/the-impact-of-granule-density-on-tabletting-and-pharmaceutical-product-performance
#4
Sander van den Ban, Daniel J Goodwin
PURPOSE: The impact of granule densification in high-shear wet granulation on tabletting and product performance was investigated, at pharmaceutical production scale. Product performance criteria need to be balanced with the need to deliver manufacturability criteria to assure robust industrial scale tablet manufacturing processes. A Quality by Design approach was used to determine in-process control specifications for tabletting, propose a design space for disintegration and dissolution, and to understand the permitted operating limits and required controls for an industrial tabletting process...
February 10, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28181841/surface-density-of-polyarginine-influence-the-size-zeta-potential-cellular-uptake-and-tissue-distribution-of-the-nanostructured-lipid-carrier
#5
Mingshuang Sun, Zhihong Zhu, Huixin Wang, Cuiyan Han, Dandan Liu, Lei Tian, Xinggang Yang, Weisan Pan
Poly-arginines are strong tools to elevate the cellular uptake of nanopreparations. To learn the influence of poly-arginine (RRRRRRRR, R8) density on a series of properties of nanostructured lipid carrier (NLC), we build six R8 modified NLCs with different R8 densities (nR-NLC, where n represents the R8 ratio) by fusion-emulsion method with the aid of stearyl-R8. The pharmaceutical characteristics like size, zeta potential and in vitro drug release, cellular uptake, cytotoxicity to A549 cells and tissue distribution in S180 tumor-bearing mice of the six nR-NLCs are all investigated...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28176905/effect-of-roll-compaction-on-granule-size-distribution-of-microcrystalline-cellulose-mannitol-mixtures-computational-intelligence-modeling-and-parametric-analysis
#6
Pezhman Kazemi, Mohammad Hassan Khalid, Ana Pérez Gago, Peter Kleinebudde, Renata Jachowicz, Jakub Szlęk, Aleksander Mendyk
Dry granulation using roll compaction is a typical unit operation for producing solid dosage forms in the pharmaceutical industry. Dry granulation is commonly used if the powder mixture is sensitive to heat and moisture and has poor flow properties. The output of roll compaction is compacted ribbons that exhibit different properties based on the adjusted process parameters. These ribbons are then milled into granules and finally compressed into tablets. The properties of the ribbons directly affect the granule size distribution (GSD) and the quality of final products; thus, it is imperative to study the effect of roll compaction process parameters on GSD...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28163225/artificial-neural-network-modelling-of-continuous-wet-granulation-using-a-twin-screw-extruder
#7
Saeed Shirazian, Manuel Kuhs, Shaza Darwish, Denise Croker, Gavin M Walker
Computational modelling of twin-screw granulation was conducted by using an artificial neural network (ANN) approach. Various ANN configurations were considered with changing hidden layers, nodes and activation functions to determine the optimum model for the prediction of the process. The neural networks were trained using experimental data obtained for granulation of pure microcrystalline cellulose using a 12mm twin-screw extruder. The experimental data were obtained for various liquid binder (water) to solid ratios, screw speeds, material throughputs, and screw configurations...
February 2, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28156583/developing-a-supportive-oncology-program-in-a-cancer-institute-needs-assessment
#8
Tara Liberman, James D'Olimpio, Maria Carney
: 141 Background: Cancer patients experience significant symptom and psychosocial burden (Temel JS, et. al. N Engl J Med. 2010 Aug 19; 363(8):733-42. Early palliative care for patients with metastatic non-small-cell lung cancer.). Integration of supportive oncology programs within cancer centers has developed since the findings of Temel and Jackson. Addressing a growing need to manage patients comprehensively, the Northwell Health Divisions of Geriatric and Palliative Medicine and Hematology and Oncology partnered to initiate a community-based supportive oncology program...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28139721/therapeutic-properties-of-scutellaria-baicalensis-in-db-db-mice-evaluated-using-connectivity-map-and-network-pharmacology
#9
Bu-Yeo Kim, Kwang Hoon Song, Chi-Yeon Lim, Su-In Cho
We have reported that an extract of Scutellaria baicalensis (ESB) has effects against obesity and hypertriglyceridemia in type 2 diabetic animal model (db/db mouse). In the present study, we tried to explain the pharmacological effects of ESB by integrating gene expression information from db/db mouse liver with that of ESB-treated HepG2 hepatocellular carcinoma cells. Using Connectivity Map (cmap) analysis, we found an inverse relationship in the pharmaceutical profiles based on gene expression between db/db mouse liver and ESB-treated HepG2 cells...
January 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28139461/slovakia-health-system-review
#10
Martin Smatana, Peter Pazitny, Daniela Kandilaki, Michaela Laktisova, Darina Sedlakova, Monika Paluskova, Ewout van Ginneken, Anne Spranger
This analysis of the Slovak health system reviews recent developments in organization and governance, health financing, health-care provision, health reforms and health system performance. The health care system in Slovakia is based on universal coverage, compulsory health insurance, a basic benefit package and a competitive insurance model with selective contracting of health care providers. Containment of health spending became a major policy goal after the 2008 financial crisis. Health spending stabilized after 2010 but remains well below European averages...
November 2016: Health Systems in Transition
https://www.readbyqxmd.com/read/28137820/pharmacokinetics-of-clindamycin-in-obese-and-non-obese-children
#11
Michael J Smith, Daniel Gonzalez, Jennifer L Goldman, Ram Yogev, Janice E Sullivan, Michael D Reed, Ravinder Anand, Karen Martz, Katherine Berezny, Daniel K Benjamin, P Brian Smith, Michael Cohen-Wolkowiez, Kevin Watt
Although obesity is prevalent among children in the United States, pharmacokinetic (PK) data in obese children are limited. Clindamycin is a commonly used antibiotic that may require dose adjustment in obese children due to its lipophilic properties. We performed a clindamycin population PK analysis using data from three separate trials. A total of 420 samples from 220 children, 76 of whom had a body mass index ≥ 95(th) percentile for age, were included in the analysis. As compared to other metrics, total body weight (TBW) was the most robust measure of body size...
January 30, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28137282/dynamic-control-of-erg20-expression-combined-with-minimized-endogenous-downstream-metabolism-contributes-to-the-improvement-of-geraniol-production-in-saccharomyces-cerevisiae
#12
Jianzhi Zhao, Chen Li, Yan Zhang, Yu Shen, Jin Hou, Xiaoming Bao
BACKGROUND: Microbial production of monoterpenes provides a promising substitute for traditional chemical-based methods, but their production is lagging compared with sesquiterpenes. Geraniol, a valuable monoterpene alcohol, is widely used in cosmetic, perfume, pharmaceutical and it is also a potential gasoline alternative. Previously, we constructed a geraniol production strain by engineering the mevalonate pathway together with the expression of a high-activity geraniol synthase. RESULTS: In this study, we further improved the geraniol production through reducing the endogenous metabolism of geraniol and controlling the precursor geranyl diphosphate flux distribution...
January 31, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/28133608/r-d-in-vaccines-targeting-neglected-diseases-an-exploratory-case-study-considering-funding-for-preventive-tuberculosis-vaccine-development-from-2007-to-2014
#13
Theolis Costa Barbosa Bessa, Erika Santos de Aragão, Jane Mary Medeiros Guimarães, Bethânia de Araújo Almeida
Based on an exploratory case study regarding the types of institutions funding the research and development to obtain new tuberculosis vaccines, this article intends to provoke discussion regarding the provision of new vaccines targeting neglected disease. Although our findings and discussion are mainly relevant to the case presented here, some aspects are more generally applicable, especially regarding the dynamics of development in vaccines to prevent neglected diseases. Taking into account the dynamics of innovation currently seen at work in the vaccine sector, a highly concentrated market dominated by few multinational pharmaceutical companies, we feel that global PDP models can play an important role throughout the vaccine development cycle...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28131444/detection-of-acanthamoeba-spp-in-water-samples-collected-from-natural-water-reservoirs-sewages-and-pharmaceutical-factory-drains-using-lamp-and-pcr-in-china
#14
Anna Lass, Milena Guerrero, Xiuping Li, Gabriele Karanis, Liqing Ma, Panagiotis Karanis
Various species of amoebas belonging to the genus Acanthamoeba are widely distributed in many parts of the world. Some strains of these protozoans may exist as parasites and pose risks to human health as causative agents of serious human diseases. Currently in China there is a lack of information about the distribution of Acanthamoeba strains in the environment. Accordingly, 261 environmental water samples taken from rivers, sewage, and pharmaceutical factory drains were collected in Qinghai Province, China...
January 25, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28124725/phorbol-esters-in-seed-oil-of-jatropha-curcas-l-saboodam-in-thai-and-their-association-with-cancer-prevention-from-the-initial-investigation-to-the-present-topics
#15
REVIEW
Hirota Fujiki, Maitree Suttajit, Anchalee Rawangkan, Keisuke Iida, Pornngarm Limtrakul, Sonthaya Umsumarng, Masami Suganuma
PURPOSE: In 1988, we first reported the complete chemical structure of a new type of phorbol ester, abbreviated to DHPB, found in seed oil of Jatropha curcas L. (Saboodam in Thai) and its tumor-promoting activity on mouse skin. Although this seed oil contains toxic phorbol ester, it was planned to use it as a feasible renewable oil and the extracted seed cake as fertilizer. This utilization value opened a new science of Jatropha curcas. METHODS: The main experimental results are cited from our publications, and the relevant literature screened from journals and PubMed...
January 25, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28121532/boosting-a-drug-s-market-share-can-cross-a-dangerous-line
#16
Thomas Reinke
Hub programs have emerged as a profitable new line of business in the sales and distribution side of the pharmaceutical industry that has got more than its fair share of wheeling and dealing. But they spell trouble if they spark collusion, threaten patients, or waste federal dollars.
July 2016: Managed Care
https://www.readbyqxmd.com/read/28115763/effect-of-egg-albumen-protein-addition-on-physicochemical-properties-and-nanostructure-of-gelatin-from-fish-skin
#17
Luyun Cai, Jianhui Feng, Xichun Peng, Joe M Regenstein, Xiuxia Li, Jianrong Li, Wei Zhao
The physicochemical properties and nanostructure of mixtures of egg albumen protein (EAP) and gelatin from under-utilised grass carp (Ctenopharyngodon idella) skins were studied. The gelatin with 1% EAP had an acceptable gel strength. The addition of 5% EAP significantly increased the melting and gelling temperatures of gelatin gels. Additionally, the colour turned white and the crystallinity was higher in gelatin gels with gradient concentrations of EAP (1, 3, and 5%). Gelatin with 5% EAP had the highest G' values while gelatin with 1% EAP had the lowest G' values...
December 2016: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28104406/a-novel-methodology-to-study-polymodal-particle-size-distributions-produced-during-continuous-wet-granulation
#18
Carlota Mendez Torrecillas, Gavin W Halbert, Dimitrios A Lamprou
It is important during powder granulation to obtain particles of a homogeneous size especially in critical situations such as pharmaceutical manufacture. To date, homogeneity of particle size distribution has been defined by the use of the d50 combined with the span of the particle size distribution, which has been found ineffective for polymodal particle size distributions. This work focuses on demonstrating the limitations of the span parameter to quantify homogeneity and proposes a novel improved metric based on the transformation of a typical particle size distribution curve into a homogeneity factor which can vary from 0 to 100%...
January 16, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28103518/adsorption-of-quinolone-tetracycline-and-penicillin-antibiotics-from-aqueous-solution-using-activated-carbons-review
#19
REVIEW
Muthanna J Ahmed
Antibiotics, an important type of pharmaceutical pollutant, have attracted many researchers to the study of their removal from aqueous solutions. Activated carbon (AC) has been widely used as highly effective adsorbent for antibiotics because of its large specific surface area, high porosity, and favorable pore size distribution. In this article, the adsorption performance of AC towards three major types of antibiotics such as tetracyclines, quinolones, and penicillins were reviewed. According to collected data, maximum adsorption capacities of 1340...
January 16, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28092984/vipera-ammodytes-bites-treated-with-antivenom-viperatab-a-case-series-with-pharmacokinetic-evaluation
#20
Miran Brvar, Tihana Kurtović, Damjan Grenc, Maja Lang Balija, Igor Križaj, Beata Halassy
CONTEXT: In clinical practice it is difficult to differentiate between V. berus and V. ammodytes venomous bites. In the past this was not a concern, but due to the current shortage in Viperfav™ and European viper venom antiserum availability, V. a. ammodytes venomous bites have recently been treated with ViperaTAb(®), which is a pharmaceutical formulation containing a monospecific ovine Fab fragments against the venom of V. berus. OBJECTIVE: To evaluate ViperaTAb(®) in V...
January 17, 2017: Clinical Toxicology
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