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https://www.readbyqxmd.com/read/29908492/treatment-of-guillain-barr%C3%A3-syndrome-with-bifidobacterium-infantis-through-regulation-of-t-helper-cells-subsets
#1
Peng Shi, Hongdang Qu, Di Nian, Yuhua Chen, Xiaolin Liu, Qiang Li, Qianqian Li, Chun Wang, Ming Ye, Bo Ma
BACKGROUND: Guillain-Barré syndrome (GBS) is a rare, autoimmune-mediated disease. The use of Bifidobacterium is reportedly effective in alleviating GBS since they act by regulating T helper (Th) cells. OBJECTIVES: In this study, we explored the differentiation of T helper cell subsets in patients with GBS. We also evaluated the effect of GBS on Bifidobacterium levels in patients and the likely protective influence of this bacterium in alleviating the disease in an animal model...
June 13, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29908119/cd4-foxp3-regulatory-t-cell-mediated-immunomodulation-by-anti-depressants-inhibiting-acid-sphingomyelinase
#2
Jürgen Schneider-Schaulies, Niklas Beyersdorf
Acid sphingomyelinase (ASM) is the rate-limiting enzyme cleaving sphingomyelin into ceramide and phosphorylcholin. CD4+ Foxp3+ regulatory T (Treg) cells depend on CD28 signaling for their survival and function, a receptor that activates the ASM. Both, basal and CD28-induced ASM activities are higher in Treg cells than in conventional CD4+ T (Tconv) cells. In ASM-deficient (Smpd1-/-) as compared to wt mice, membranes of T cells contain 7-10-fold more sphingomyelin and 2-3-fold more ceramide, and are in a state of higher order than membranes of T cells from wt mice, which may facilitate their activation...
June 1, 2018: Biological Chemistry
https://www.readbyqxmd.com/read/29907586/yap-is-essential-for-treg-mediated-suppression-of-anti-tumor-immunity
#3
Xuhao Ni, Jinhui Tao, Joseph Barbi, Qian Chen, Benjamin V Park, Zhiguang Li, Nailing Zhang, Andriana Lebid, Anjali Ramaswamy, Ping Wei, Ying Zheng, Xuehong Zhang, Xingmei Wu, Paolo D A Vignali, Cuiping Yang, Huabin Li, Drew Pardoll, Ling Lu, Duojia Pan, Fan Pan
Regulatory T cells (Tregs) are critical for maintaining self-tolerance and immune homeostasis, but their suppressive function can impede effective anti-tumor immune responses. Foxp3 is a transcription factor expressed in Tregs that is required for their function. However, the pathways and microenvironmental cues governing Foxp3 expression and Treg function are not completely understood. Herein, we report that Yes-associated protein (YAP), a co-activator of the Hippo pathway, is highly expressed in Tregs and bolsters Foxp3 expression and Treg function in vitro and in vivo...
June 15, 2018: Cancer Discovery
https://www.readbyqxmd.com/read/29907525/tissue-restricted-adaptive-type-2-immunity-is-orchestrated-by-expression-of-the-costimulatory-molecule-ox40l-on-group-2-innate-lymphoid-cells
#4
Timotheus Y F Halim, Batika M J Rana, Jennifer A Walker, Bernhard Kerscher, Martin D Knolle, Helen E Jolin, Eva M Serrao, Liora Haim-Vilmovsky, Sarah A Teichmann, Hans-Reimer Rodewald, Marina Botto, Timothy J Vyse, Padraic G Fallon, Zhi Li, David R Withers, Andrew N J McKenzie
The local regulation of type 2 immunity relies on dialog between the epithelium and the innate and adaptive immune cells. Here we found that alarmin-induced expression of the co-stimulatory molecule OX40L on group 2 innate lymphoid cells (ILC2s) provided tissue-restricted T cell co-stimulation that was indispensable for Th2 and regulatory T (Treg) cell responses in the lung and adipose tissue. Interleukin (IL)-33 administration resulted in organ-specific surface expression of OX40L on ILC2s and the concomitant expansion of Th2 and Treg cells, which was abolished upon deletion of OX40L on ILC2s (Il7raCre/+ Tnfsf4fl/fl mice)...
May 31, 2018: Immunity
https://www.readbyqxmd.com/read/29907361/mesenchymal-stem-cell-expression-of-interleukin-35-protects-against-ulcerative-colitis-by-suppressing-mucosal-immune-responses
#5
Yongjia Yan, Na Zhao, Xianghui He, Hao Guo, Zhixiang Zhang, Tong Liu
BACKGROUND: Interleukin-35 (IL-35) has recently been identified as an immunosuppressive cytokine that has been used as a potential therapy for chronic inflammatory and autoimmune diseases. However, there remains a paucity of data regarding its potential benefits after integration into mesenchymal stem cells (MSCs). METHODS: We used a dextran sulfate sodium (DSS)-induced colitis mice model and treated them with IL-35-MSCs, MSCs or saline. The body weight was recorded daily and inflammatory processes were determined...
June 12, 2018: Cytotherapy
https://www.readbyqxmd.com/read/29906568/higher-cd45ra-regulatory-t-cells-in-the-graft-improves-outcome-in-younger-patients-undergoing-t-cell-replete-haploidentical-transplantation-where-donor-age-matters
#6
Sarita Rani Jaiswal, Prakash Bhakuni, Aby Joy, Nisha Murli, Ashok Rajoreya, Aditi Chakrabarti, Suparno Chakrabarti
To understand the phenomenon of early alloreactivity (EA) in younger children undergoing post-transplantation cyclophosphamide (PTCy) based haploidentical transplantation, we studied the graft composition and the immune reconstitution in 32 consecutive patients (age 2-25 years) undergoing PTCy and T cell costimulation blockade based PBSC transplantation with emphasis on CD45RA+ subset of Tregs. All but one engrafted and 14 patients experienced EA (acuteGVHD grade II-IV- 8 and PTHPS-6) with a cumulative incidence of 43...
June 12, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29905955/co-expression-of-lag3-and-tim3-identifies-a-potent-treg-population-that-suppresses-macrophage-functions-in-colorectal-cancer-patients
#7
Qiang Ma, Junning Liu, Guoliang Wu, Mujian Teng, Shaoxuan Wang, Meng Cui, Yuantao Li
Regulatory T (Treg) cells are critical suppressors of inflammation and are thought to exert mainly deleterious effects in cancers. In colorectal cancer (CRC), Foxp3+  Treg accumulation in the tumor was associated with poor prognosis. Hence, we examined the circulating Treg cells in CRC patients. Compared to controls, CRC patients presented mild upregulations in CD4+ CD25+/hi T cells and in the more canonical CD4+ CD25+/hi Foxp3+ Treg cells in peripheral blood mononuclear cells. Both of these Treg populations could be roughly divided into LAG3- TIM3- and LAG3+ TIM3+ subsets...
June 15, 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29904967/downregulation-of-ilt4-dendritic-cells-in-recurrent-miscarriage-and-recurrent-implantation-failure
#8
Su Liu, Hongxia Wei, Yuye Li, Chunyu Huang, Ruochun Lian, Jian Xu, Lanna Chen, Yong Zeng
PROBLEM: The role of ILT4+ DCs in healthy fertile controls and patients with recurrent miscarriages (RM) and recurrent implantation failure (RIF) is unclear. METHOD OF STUDY: We studied the expression of ILT4 from peripheral blood and endometrial samples from healthy controls and patients with RM and RIF by flow cytometry and immunohistochemistry analysis. Endometrial Foxp3 expression was also investigated using immunohistochemistry. RESULTS: In peripheral blood, there was a significant increase in the percentage of ILT4+ DCs in healthy fertile controls compared with patients with RM and RIF...
June 14, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29904934/common-gamma-chain-cytokines-promote-regulatory-t-cell-development-and-survival-at-the-cd4-cd8-stage-in-the-human-thymus
#9
Reetta Vanhanen, Anni Tuulasvaara, Joonatan Mattila, Tommi Pätilä, T Petteri Arstila
Thymic commitment of human FOXP3+ regulatory T cells begins at the double positive (DP) CD4+ CD8+ stage. In the current study we show that interleukin-2 promotes the development of FOXP3+ thymocytes and enhances their survival at the DP phase. IL-2 increases the frequency of FOXP3+ cells and promotes the Treg phenotype after TCR-mediated positive selection at the most mature DP stage. However, it has no effect on FOXP3+ cells at the earlier maturation steps before positive selection. DP FOXP3+ are highly susceptible to cell death but IL-2 promotes their survival...
June 15, 2018: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/29904348/berberine-regulates-treg-th17-balance-to-treat-ulcerative-colitis-through-modulating-the-gut-microbiota-in-the-colon
#10
Huantian Cui, Yuzi Cai, Li Wang, Beitian Jia, Junchen Li, Shuwu Zhao, Xiaoqian Chu, Jin Lin, Xiaoyu Zhang, Yuhong Bian, Pengwei Zhuang
Berberine (BBR), an alkaloid isolated from Rhizoma Coptidis, Cortex Phellode , and Berberis , has been widely used in the treatment of ulcerative colitis (UC). However, the mechanism of BBR on UC is unknown. In this study, we investigated the activities of T regulatory cell (Treg) and T helper 17 cell (Th17) in a dextran sulfate sodium (DSS)-induced UC mouse model after BBR administration. We also investigated the changes of gut microbiota composition using 16S rRNA analysis. We also examined whether BBR could regulate the Treg/Th17 balance by modifying gut microbiota...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29903654/anti-pruritic-and-anti-inflammatory-effects-of-oxymatrine-in-a-mouse-model-of-allergic-contact-dermatitis
#11
Xiaoyun Xu, Wei Xiao, Zhe Zhang, Jianhao Pan, Yixi Yan, Tao Zhu, Dan Tang, Kaihe Ye, Manish Paranjpe, Lintao Qu, Hong Nie
BACKGROUND: Allergic contact dermatitis (ACD) is a highly prevalent inflammatory disease of the skin. As a result of the complex etiology in ACD, therapeutic compounds targeting refractory pruritus in ACD lack efficacy and lead to numerous side effects. OBJECTIVE: In this study, we investigated the anti-pruritic effects of oxymatrine (OMT) and explored its mechanism of action in a mouse model of ACD. METHOD: 72 male SPF C57BL/6 mice were randomly divided into control group, ACD model group, dexamethasone positive control group (0...
May 31, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29903026/serum-ifn-%C3%AE-levels-predict-the-therapeutic-effect-of-mesenchymal-stem-cell-transplantation-in-active-rheumatoid-arthritis
#12
Yi Yang, Xiao He, Rongseng Zhao, Wei Guo, Ming Zhu, Wei Xing, Dongpo Jiang, Chongyang Liu, Xiang Xu
BACKGROUND: To explore the mechanism of the different clinical efficacies of mesenchymal stem cell transplantation (MSCT) and identify a possible serum biomarker for predicting the therapeutic effect of MSCT in rheumatoid arthritis (RA) patients. METHODS: A total of 105 patients with persistently active RA and poor responses to traditional medication were randomly divided into MSCT and control groups. Outcomes were evaluated according to the 28-joint Disease Activity Score and Health Assessment Questionnaire, serological indicators, regulatory T cell (Treg) to T helper 17 (Th17) cell ratio, and inflammatory cytokine levels...
June 15, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29901858/hypoxia-inducible-factor-1%C3%AE-plays-a-predominantly-negative-role-in-regulatory-t-cell-functions
#13
REVIEW
Tzu-Sheng Hsu, Ming-Zong Lai
Hypoxia-inducible factor 1α (HIF-1α) regulates cellular responses to hypoxia. However, conflicting roles for HIF-1α in the functions of regulatory T cells (Tregs) have been reported. In this review, we summarize observations on the requirement for HIF-1α for FOXP3 expression and Tregs development, as well as for HIF-1α-mediated downregulation of FOXP3 and Tregs destabilization. We also examine the association of HIF-1α with Tregs under pathogenic conditions. Based on these findings, we suggest that HIF-1α mainly plays a detrimental role in the function and stability of Tregs and that HIF-1α is disposable for the development and suppressive function of Tregs...
June 14, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29901635/rapamycin-treatment-for-amyotrophic-lateral-sclerosis-protocol-for-a-phase-ii-randomized-double-blind-placebo-controlled-multicenter-clinical-trial-rap-als-trial
#14
Jessica Mandrioli, Roberto D'Amico, Elisabetta Zucchi, Annalisa Gessani, Nicola Fini, Antonio Fasano, Claudia Caponnetto, Adriano Chiò, Eleonora Dalla Bella, Christian Lunetta, Letizia Mazzini, Kalliopi Marinou, Gianni Sorarù, Sara de Biasi, Domenico Lo Tartaro, Marcello Pinti, Andrea Cossarizza
INTRODUCTION: Misfolded aggregated proteins and neuroinflammation significantly contribute to amyotrophic lateral sclerosis (ALS) pathogenesis, hence representing therapeutic targets to modify disease expression. Rapamycin inhibits mechanistic target of Rapamycin (mTOR) pathway and enhances autophagy with demonstrated beneficial effects in neurodegeneration in cell line and animal models, improving phenotype in SQSTM1 zebrafish, in Drosophila model of ALS-TDP, and in the TDP43 mouse model, in which it reduced neuronal loss and TDP43 inclusions...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29901436/human-gastric-cancer-mesenchymal-stem-cell-derived-il15-contributes-to-tumor-cell-emt-via-up-regulation-of-tregs-ratio-and-pd-1-expression-in-cd4-t-cell
#15
Li Sun, Qianqian Wang, Bin Chen, Yuanyaun Zhao, Bo Shen, Xinlong Wang, Miaolin Zhu, Zhuqian Li, Xiangdong Zhao, Changgen Xu, Zhihong Chen, Mei Wang, Wenrong Xu, Wei Zhu
Several studies show that mesenchymal stem cells (MSCs) homing to tumors not only provide the microenvironment for tumor cells, but also promote tumor growth and metastasis. However, the exact mechanism remains unclear. Our study aims to investigate the role of gastric cancer MSCs (GCMSCs) derived IL15 during GC progression. The effects of IL15 secreted by GCMSCs on GC development were evaluated by detecting the stemness, epithelial-mesenchymal transition (EMT) and migration abilities of GC cell lines. The expression of IL15 in serum and tissues of GC patients was also assessed...
June 14, 2018: Stem Cells and Development
https://www.readbyqxmd.com/read/29901207/aberrant-expression-of-foxp3-in-a-human-t-cell-line-possessing-regulatory-t-cell%C3%A2-like-function-and-exposed-continuously-to-asbestos-fibers
#16
Megumi Maeda, Hidenori Matsuzaki, Shoko Yamamoto, Suni Lee, Naoko Kumagai-Takei, Kei Yoshitome, Yu Min, Nagisa Sada, Yasumitsu Nishimura, Takemi Otsuki
Prompted by the known carcinogenic activity of asbestos, our investigations revealed that asbestos causes a reduction in antitumor immunity. One mechanism involves the enhancement of regulatory T (Treg) cell function and volume assayed using MT‑2 original cells (Org), an HTLV‑1 immortalized human T cell line which possesses Treg‑like function. Continuous and relatively low‑dose exposure of MT‑2 to asbestos fibers yielded sublines resistant to asbestos‑induced apoptosis and enhanced Treg function via cell‑cell contact mechanisms and increased the production of soluble factors such as interleukin (IL)‑10 and transforming growth factor (TGF)‑β...
June 7, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29901094/fennel-main-constituent-trans%C3%A2-anethole-treatment-against-lps%C3%A2-induced-acute-lung-injury-by-regulation-of-th17-treg-function
#17
Sichao Zhang, Xi Chen, Ichinkhorloo Devshilt, Qi Yun, Cong Huang, Lijun An, Sosorburam Dorjbat, Xin He
Fennel, commonly used in traditional Chinese medicine, is known as Foeniculum vulgare Mill. And its clinical application has been shown to target many biological systems including gastroenterology, endocrinology, gynecology and respiratory. The main constituent of the fennel essential oil is trans‑anethole, which has been described to have anti‑inflammatory and antibacterial activities. The aim of the present study was to define the anti‑inflammatory influence in acute lung injury (ALI)‑bearing mice...
June 7, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29900065/the-immune-checkpoint-protein-pd-l1-induces-and-maintains-regulatory-t-cells-in-glioblastoma
#18
Joseph DiDomenico, Jonathan B Lamano, Daniel Oyon, Yuping Li, Dorina Veliceasa, Gurvinder Kaur, Leonel Ampie, Winward Choy, Jason B Lamano, Orin Bloch
Glioblastoma (GBM) promotes immunosuppression through upregulation of PD-L1 and regulatory T cell (Treg) expansion, but the association of these suppressive factors has not been well elucidated. Here, we investigate a role of PD-L1 in expanding Tregs and the value of targeting the PD-1 receptor to inhibit Treg expansion. Quantitative RNA sequencing data from The Cancer Genome Atlas were evaluated for an association between CD274 and FOXP3 transcript expressions and impact of FOXP3 on clinical outcomes. Peripheral leukocytes from patients with newly diagnosed GBM were profiled for PD-L1+ myeloid expressions and Treg abundance...
2018: Oncoimmunology
https://www.readbyqxmd.com/read/29900064/induction-of-enhanced-immunogenic-cell-death-through-ultrasound-controlled-release-of-doxorubicin-by-liposome-microbubble-complexes
#19
Feng-Ying Huang, Jing Lei, Yan Sun, Fei Yan, Bin Chen, Liming Zhang, Zhuoxuan Lu, Rong Cao, Ying-Ying Lin, Cai-Chun Wang, Guang-Hong Tan
Immunogenic cell death (ICD) is a specific kind of cell death that stimulates the immune system to combat cancer cells. Ultrasound (US)-controlled targeted release of drugs by liposome-microbubble complexes is a promising approach due to its non-invasive nature and visibility through ultrasound imaging. However, it is not known whether this approach can enhance ICD induced by drugs, such as doxorubicin. Herein, we prepared a doxorubicin-liposome-microbubble complex (MbDox), and the resultant MbDox was then characterized and tested for US-controlled release of Dox (MbDox+US treatment) to enhance the induction of ICD in LL/2 and CT26 cancer cells and in syngeneic murine models...
2018: Oncoimmunology
https://www.readbyqxmd.com/read/29900058/optimized-dendritic-cell-vaccination-induces-potent-cd8-t-cell-responses-and-anti-tumor-effects-in-transgenic-mouse-melanoma-models
#20
Mareike Grees, Adi Sharbi-Yunger, Christos Evangelou, Daniel Baumann, Gal Cafri, Esther Tzehoval, Stefan B Eichmüller, Rienk Offringa, Jochen Utikal, Lea Eisenbach, Viktor Umansky
Despite melanoma immunogenicity and remarkable therapeutic effects of negative immune checkpoint inhibitors, a significant fraction of patients does not respond to current treatments. This could be due to limitations in tumor immunogenicity and profound immunosuppression in the melanoma microenvironment. Moreover, insufficient tumor antigen processing and presentation by dendritic cells (DC) may hamper the development of tumor-specific T cells. Using two genetically engineered mouse melanoma models ( RET and BRAFV600E transgenic mice), in which checkpoint inhibitor therapy alone is not efficacious, we performed proof-of-concept studies with an improved, multivalent DC vaccination strategy based on our recently developed genetic mRNA cancer vaccines...
2018: Oncoimmunology
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