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https://www.readbyqxmd.com/read/29098825/-water-soluble-constituents-from-the-twigs-of-litsea-cubeba
#1
Ling-Yan Wang, Yu-Hong Qu, Yan-Cheng Li, Yu-Zhuo Wu, Rui Li, Qing-Lan Guo, Su-Juan Wang, Ya-Nan Wang, Yong-Chun Yang, Sheng Lin
Twenty five known aromatic glycosides (1-25) and three known sesquiterpene glycosides (26-28) have been isolated from the twigs of Litsea cubeba by using various chromatographic techniques. Their structures were identified by spectroscopic data analysis (MS, IR, 1D and 2D NMR) as (7S,8R)-dehydrodiconiferyl alcohol 4,9'-di-O-β-D-glucopyranoside(1),(7S,8R)-5-methoxydihydrodehydrodiconiferyl alcohol 4-O-β-D-glucopyranoside(2), (7S,8R)-urolignoside(3), (7R,8S)-dihydrodehydrodiconiferyl alcohol 4-O-β-D-glucopyranoside(4), saposide B(5), lanicepside A(6), matairesinol-4-O-β-D-glucopyranoside (7), tyraxjaponoside B(8), (+)-lyoniresinol-9'-O-β-D-glucopyranoside (9), alaschanisoside A (10), syringin (11), psoralenoside (12), isopsoralenoside (13), scopolin(14), 2,6-dimethoxy-4-hydroxyphenol-1-O-β-D-glucopyranoside (15), 3-hydroxy-4,5-dimethoxyphenyl-β-D-glucopyranoside (16), 2-(3,4-dihydroxyphenyl)ethyl-β-D-glucopyrnoside (17), 2-(4-dihydroxyphenyl)ethyl-β-D-glucopyranoside (18), (+)-catechin-7-O-β-D-glucopyranoside (19), 3'-O-methylepicatechin-7-O-β-D-glucopyranoside (20), kaempferitrin (21), quercetin-3-O-α-L-rhamnopyranside (22), kaempferol-3-O-β-D-glucopyranoside (23), kaempferol 3-O-β-D-glucopyranosyl(1→2)-O-β-D-galactopyr anoside-7-O-α-L-rhamnopyranoside (24), quercetin 3-O-α-L-rhamnopyranosyl(1→6)-O-β-D-glucopyranosyl(1→3)-O-α-L-rhamnopyranosyl(1→2)-O-β-D-glucopyranoside (25), staphylionoside D(26), vomifoliol 9-O-β-D-glucopyranoside (27), dihydrovomifoliol-O-β-D-glucopyranoside (28)...
July 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28925259/pinus-pinaster-knot-a-source-of-polyphenols-against-plasmopara-viticola
#2
Julien Gabaston, Tristan Richard, Stéphanie Cluzet, Antonio Palos Pinto, Marie-Cécile Dufour, Marie-France Corio-Costet, Jean-Michel Mérillon
Pine knot extract from Pinus pinaster byproducts was characterized by UHPLC-DAD-MS and NMR. Fourteen polyphenols divided into four classes were identified as follows: lignans (nortrachelogenin, pinoresinol, matairesinol, isolariciresinol, secoisolariciresinol), flavonoids (pinocembrin, pinobanksin, dihydrokaempferol, taxifolin), stilbenes (pinosylvin, pinosylvin monomethyl ether, pterostilbene), and phenolic acids (caffeic acid, ferulic acid). The antifungal potential of pine knot extract, as well as the main compounds, was tested in vitro against Plasmopara viticola...
October 11, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28817364/association-between-dietary-phytoestrogens-intakes-and-prostate-cancer-risk-in-sicily
#3
Giorgio I Russo, Marina Di Mauro, Federica Regis, Giulio Reale, Daniele Campisi, Marina Marranzano, Arturo Lo Giudice, Tatiana Solinas, Massimo Madonia, Sebastiano Cimino, Giuseppe Morgia
OBJECTIVE: In this study we aimed to investigate the association between dietary phytoestrogen consumption and prostate cancer in a sample of southern Italian individuals. METHODS: A population-based case-control study on the association between prostate cancer and dietary factors was conducted from January 2015 to December 2016 in a single institution of the municipality of Catania, southern Italy (Registration number: 41/2015). A total of 118 histopathological-verified prostate cancer (PCa) cases and a total of 222 controls were collected...
August 17, 2017: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/28669348/the-structural-bioinformatics-analysis-of-biophenolic-lignan-estrogen-receptor-interaction
#4
Farzaneh Mohamadyar-Toupkanlou, Mina Esfandiari, Mahshid Sadat Kashef-Saberi, Mahboubeh Kabiri Renani, Masoud Soleimani
BACKGROUND: Plant lignans have proven efficacious in blocking estrogen receptors of breast cancer cells. However, available studies have mostly dealt with anti-cancer effects of groups of lignans in certain foods or plants and the effects of specific lignans, especially from a molecular interaction viewpoint, has been rarely addressed in the literature. OBJECTIVE: We aimed to computationally predict the binding ability and binding strength of pinoresinol, matairesinol, lariciresinol and secoisolariciresinol as potent ligands of estrogen receptor alpha (ER-α), in order to study these lignans as drugs...
June 23, 2017: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/28629933/lignans-from-the-root-of-wikstroemia-indica-and-their-cytotoxic-activity-against-panc-1-human-pancreatic-cancer-cells
#5
Hang Chang, Yuwei Wang, Xue Gao, Zehai Song, Suresh Awale, Na Han, Zhihui Liu, Jun Yin
Six new compounds, wikstronin A (1), wikstronin B (2), wikstresinol (3), acetylwikstresinol (4), bis-5',5'-(+)-matairesinol (5), bis-5,5'-(+)-matairesinol (6), together with 20 known compounds (7-26) were isolated from the CH2Cl2 extract of roots of Wikstroemia indica. Structures of compounds 1-6 were determined by extensive NMR and CD spectroscopic analysis. In vitro preferential cytotoxicity of all the isolates was evaluated against a PANC-1 human pancreatic cell line. Compounds 8 and 12 displayed mild preferential cytotoxicity in the nutrient-deprived medium (NDM) and without causing toxicity in normal nutrient-rich conditions...
September 2017: Fitoterapia
https://www.readbyqxmd.com/read/28525714/characterization-of-bitter-compounds-via-modulation-of-proton-secretion-in-human-gastric-parietal-cells-in-culture
#6
Kathrin I Liszt, Joachim Hans, Jakob P Ley, Elke Köck, Veronika Somoza
Humans perceive bitterness via around 25 different bitter receptors. Therefore, the identification of antagonists remains a complex challenge. We previously demonstrated several bitter tasting compounds such as caffeine to induce acid secretion in the stomach and in a human gastric tumor cell line (HGT-1). Here, the results of a fluorescent-based in vitro assay using HGT-1 cells and a human sensory panel testing nine selected potential bitter modulators with or without the bitter compounds caffeine or theobromine, were compared...
May 19, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28512713/matairesinol-suppresses-neuroinflammation-and-migration-associated-with-src-and-erk1-2-nf-%C3%AE%C2%BAb-pathway-in-activating-bv2-microglia
#7
Peng Xu, Meng-Wei Huang, Chen-Xi Xiao, Fen Long, Ying Wang, Si-Yu Liu, Wan-Wan Jia, Wei-Jun Wu, Di Yang, Jin-Feng Hu, Xin-Hua Liu, Yi-Zhun Zhu
Chronic neuroinflammation is a pathological feature of neurodegenerative diseases. Inhibition of microglia-mediated neuroinflammation might be a potential strategy for neurodegeneration. Matairesinol, a dibenzylbutyrolactone plant lignan, presents in a wide variety of foodstuffs. It has been found to possess anti-angiogenic, anti-oxidative, anti-cancer and anti-fungal activities. In the present study, we investigated the anti-neuroinflammation effects of matairesinol on lipopolysaccharide (LPS)-induced BV2 microglia cells and the related molecular mechanisms...
May 17, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28152041/differential-and-directional-estrogenic-signaling-pathways-induced-by-enterolignans-and-their-precursors
#8
Yun Zhu, Kayoko Kawaguchi, Ryoiti Kiyama
Mammalian lignans or enterolignans are metabolites of plant lignans, an important category of phytochemicals. Although they are known to be associated with estrogenic activity, cell signaling pathways leading to specific cell functions, and especially the differences among lignans, have not been explored. We examined the estrogenic activity of enterolignans and their precursor plant lignans and cell signaling pathways for some cell functions, cell cycle and chemokine secretion. We used DNA microarray-based gene expression profiling in human breast cancer MCF-7 cells to examine the similarities, as well as the differences, among enterolignans, enterolactone and enterodiol, and their precursors, matairesinol, pinoresinol and sesamin...
2017: PloS One
https://www.readbyqxmd.com/read/28105861/a-novel-benzimidazole-and-other-constituents-with-antiproliferative-and-antioxidant-properties-from-thymelaea-microphylla-coss-et-dur
#9
Labib Noman, Feyza Oke-Altuntas, Amar Zellagui, Ayse Sahin Yaglioglu, Ibrahim Demirtas, Susana M Cardoso, Salah Akkal, Noureddine Gherraf, Salah Rhouati
A new compound (microphybenzimidazole, 7) along with the six known compounds matairesinol (1), prestegane B (2), umbelliferone (3), daphnoretin (4), microphynolide A (5) and microphynolide B (6) were isolated from Thymelaea microphylla. The structures of the pure compounds were elucidated by spectroscopic and mass-spectrometric analyses, including 1D-, 2D-NMR, and HPLC-TOF/MS. Compounds 2 and 4, as well as three fractions (F6, F6-C5, and F6-W42) obtained from a 50% (v:v) CH2Cl2:MeOH extract exhibited a selective activity against rat brain glioma cells (C6)...
September 2017: Natural Product Research
https://www.readbyqxmd.com/read/27774796/lignans-from-the-shed-trunk-barks-of-the-critically-endangered-plant-abies-beshanzuensis-and-their-anti-neuroinflammatory-activities
#10
Chang-Ling Hu, Juan Xiong, Peng Xu, Ke-Jun Cheng, Guo-Xun Yang, Jin-Feng Hu
During a further and comprehensive phytochemical investigation on the shed trunk barks of the critically endangered plant Abies beshanzuensis, one new (1) and ten known (2-11) lignans with diverse structures were isolated. On the basis of spectroscopic methods, the new structure was established to be (7S,8R,8'R)-4'-methoxyl-α-conidendrin (1). Among the isolated lignans, (-)-matairesinol (5) and (-)-arctigenin (6) showed significant anti-neuroinflammatory activities by inhibiting the overproduction of nitric oxide in lipopolysaccharide-stimulated murine BV-2 microglial cells, with IC50 values of 11...
June 2017: Natural Product Research
https://www.readbyqxmd.com/read/27768772/de-novo-transcriptomes-of-forsythia-koreana-using-a-novel-assembly-method-insight-into-tissue-and-species-specific-expression-of-lignan-biosynthesis-related-gene
#11
Akira Shiraishi, Jun Murata, Erika Matsumoto, Shin Matsubara, Eiichiro Ono, Honoo Satake
Forsythia spp. are perennial woody plants which are one of the most extensively used medicinal sources of Chinese medicines and functional diets owing to their lignan contents. Lignans have received widespread attention as leading compounds in the development of antitumor drugs and healthy diets for reducing the risks of lifestyle-related diseases. However, the molecular basis of Forsythia has yet to be established. In this study, we have verified de novo deep transcriptome of Forsythia koreana leaf and callus using the Illumina HiSeq 1500 platform...
2016: PloS One
https://www.readbyqxmd.com/read/27740756/validated-lc-ms-ms-method-for-the-quantification-of-free-and-bound-lignans-in-cereal-based-diets-and-feces
#12
Natalja P Nørskov, Knud Erik Bach Knudsen
Despite the extensive literature describing the biological effects of phenolic compounds from cereals, little is known about their bioaccessibility in the food matrix. This paper describes a validated LC-MS/MS method for the quantification of free and total content (free + bound) of eight plant lignans (matairesinol, hydroxymatairesinol, secoisolariciresinol, lariciresinol, isolariciresinol, syringaresinol, medioresinol, and pinoresinol) and two enterolignans (enterodiol and enterolactone) in cereal-based diets/bread and feces...
November 9, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27687296/phytoestrogens-and-risk-of-prostate-cancer-an-updated-meta-analysis-of-epidemiologic-studies
#13
REVIEW
Qiang Zhang, Hongliang Feng, Bakare Qluwakemi, Jiaqi Wang, Songpo Yao, Guangdong Cheng, Hui Xu, Hongbin Qiu, Liling Zhu, Mingxia Yuan
This updated meta-analysis was performed to clarify the relationship between phytoestrogens and prostate cancer risk. Twenty one case-control and two cohort studies were finally selected for this meta-analysis, totaling 11,346 cases and 140,177 controls. Analytical results showed that daidzein (OR = 0.85; 95% CI: 0.75-0.96), genistein (OR = 0.87; 95% CI: 0.78-0.98), and glycitein (OR = 0.89; 95% CI: 0.81-0.98) were associated with a reduction of prostate cancer risk, but total isoflavones (OR = 0...
February 2017: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/27623718/new-phytochemicals-as-potential-human-anti-aging-compounds-reality-promise-and-challenges
#14
Rúbia C G Corrêa, Rosane M Peralta, Charles W I Haminiuk, Giselle Maria Maciel, Adelar Bracht, Isabel C F R Ferreira
Aging is an inevitable process influenced by genetic, lifestyle, and environmental factors. Indirect evidence shows that several phytochemicals can have anti-aging capabilities, although direct evidence in this field is still limited. This report aims to provide a critical review on aspects related to the use of novel phytochemicals as anti-aging agents, to discuss the obstacles found when performing most anti-aging study protocols in humans, and to analyze future perspectives. In addition to the extensively studied resveratrol, epicatechin, quercetin, and curcumin, new phytochemicals have been reported to act as anti-aging agents, such as the amino acid L-theanine isolated from green tea, and the lignans arctigenin and matairesinol isolated from Arctium lappa seeds...
September 13, 2016: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/27609488/lignans-and-indole-alkaloids-from-the-seeds-of-centaurea-vlachorum-hartvig-asteraceae-growing-wild-in-albania-and-their-biological-activity
#15
Entela Hodaj, Olga Tsiftsoglou, Sokol Abazi, Dimitra Hadjipavlou-Litina, Diamanto Lazari
The present phytochemical investigation of the seeds of Centaurea vlachorum led to the isolation and characterisation of four compounds including two indole alkaloids N-(p-coumaroyl) serotonin (1) and moschamine (2) and two dibenzylbutyrolactone lignans matairesinol (3) and arctiin (4). This is the first report on the isolation of non-volatile secondary metabolites from C. vlachorum. The chemataxonomic significance of these compounds was summarised. Moreover, the isolated compounds were tested for their free radical scavenging activity using the following in vitro assays: (i) interaction with the free stable radical of DPPH (1,1-diphenyl-2-picrylhydrazyl), (ii) inhibition of linoleic acid peroxidation with the dihydrochloric acid of 2,2-Azobis-2-amidinopropane (AAPH)...
May 2017: Natural Product Research
https://www.readbyqxmd.com/read/27315720/inhibitory-activity-of-podophyllotoxin-and-matairesinol-derivative-lignans-on-the-root-growth-of-brassica-campestris
#16
M Arimoto, S Matsuura, C Muro, H Tsujibo, E Matsumura, H Yamaguchi, Y Inamori
All the lignans tested in a bioassay with Brassica campestris L. subsp. rapa Hook. fil. et Anders inhibited the root growth of this plant, except for deoxypicropodophyllin. The effects of functional groups in the molecule on the inhibitory activity of these compounds were studied. It is suggested that the methylenedioxyl group and the stereochemical configuration of the lactone junction of podophyllotoxin derivatives were closely related to the inhibitory activity. The O-methyl derivative of two hydroxyl groups of matairesinol greatly enhanced the inhibition of root growth in this plant...
January 1994: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/27134764/refined-spruce-resin-to-treat-chronic-wounds-rebirth-of-an-old-folkloristic-therapy
#17
REVIEW
Janne J Jokinen, Arno Sipponen
Significance: The treatment of chronic wounds results in an enormous drain on healthcare resources in terms of workload, costs, frustration, and impaired quality of life, and it presents a clinical challenge for physicians worldwide. Effective local treatment of a chronic wound has an important role, particularly in patients who are-because of their poor general condition, diminished life expectancy, or unacceptable operative risk-outside of surgical treatment. Recent Advances: Since 2002, our multidisciplinary research group has investigated the properties of Norway spruce (Picea abies) resin in wound healing and its therapeutic applications in wound care...
May 1, 2016: Advances in Wound Care
https://www.readbyqxmd.com/read/27085937/forsythia-suspensa-fruit-extracts-and-the-constituent-matairesinol-confer-anti-allergic-effects-in-an-allergic-dermatitis-mouse-model
#18
Yoon-Young Sung, A Yeong Lee, Ho Kyoung Kim
ETHNOPHARMACOLOGICAL RELEVANCE: Forsythia suspensa is used in traditional medicine to treat inflammation. To clarify the anti-inflammatory and anti-allergic effects of F. suspensa fruits, we determined the therapeutic effects of crude extract, fractions, and a constituent from F. suspensa fruits on a murine atopic dermatitis (AD) model. MATERIALS AND METHODS: We investigated the inhibitory effects of F. suspensa extract (FSE), extract fractions, and the constituent matairesinol on histamine release from MC/9 mast cells activated by compound 48/80 and the development of AD-like skin lesions and symptoms in NC/Nga mice exposed to Dermatophagoides farinae (mite) extract...
July 1, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/26873880/detection-of-novel-metabolites-of-flaxseed-lignans-in-vitro-and-in-vivo
#19
Andrea Quartieri, Rocío García-Villalba, Alberto Amaretti, Stefano Raimondi, Alan Leonardi, Maddalena Rossi, Francisco Tomàs-Barberàn
SCOPE: This study aimed to improve the knowledge of secoisolariciresinol diglucoside (SDG) transformation by human gut microbiota. METHODS AND RESULTS: SDG-supplemented microbiota cultures were inoculated with the feces of five subjects. The same volunteers received a flaxseed supplement for 7 days. SDG metabolites in cultures, feces, and urine were monitored by LC-ESI-QTOF and LC-DAD. In all cultures, SDG was deglycosylated to secoisolariciresinol (SECO) within 12 h...
July 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/26471600/intake-of-selected-bioactive-compounds-from-plant-food-supplements-containing-fennel-foeniculum-vulgare-among-finnish-consumers
#20
Liisa Uusitalo, Maija Salmenhaara, Merja Isoniemi, Alicia Garcia-Alvarez, Lluís Serra-Majem, Lourdes Ribas-Barba, Paul Finglas, Jenny Plumb, Pirkko Tuominen, Kirsti Savela
The purpose of this study was to estimate the intake of selected bioactive compounds from fennel-containing plant food supplements (PFS) among Finnish consumers. The estimated average intake of estragole was 0.20mg/d, of trans-anethole 1.15mg/d, of rosmarinic acid 0.09mg/d, of p-coumaric acid 0.0068mg/d, of kaempferol 0.0034mg/d, of luteolin 0.0525μg/d, of quercetin 0.0246mg/d, of matairesinol 0.0066μg/d and of lignans 0.0412μg/d. The intakes of kaempferol, quercetin, luteolin, matairesinol and lignans from PFS were low in comparison with their dietary supply...
March 1, 2016: Food Chemistry
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