keyword
https://read.qxmd.com/read/38265718/methods-for-studying-swimming-and-surface-motilities-in-rhizobia
#21
JOURNAL ARTICLE
Francisco Fuentes-Romero, Cynthia Alías-Villegas, Pilar Navarro-Gómez, Sebastián Acosta-Jurado, Lydia M Bernabéu-Roda, Virginia Cuéllar, María J Soto, José M Vinardell
Rhizobia are soil proteobacteria able to establish a nitrogen-fixing interaction with legumes. In this interaction, rhizobia must colonize legume roots, infect them, and become hosted inside new organs formed by the plants and called nodules. Rhizobial motility, not being essential for symbiosis, might affect the degree of success of the interaction with legumes. Because of this, the study of rhizobial motility (either swimming or surface motility) might be of interest for research teams working on rhizobial symbiotic performance...
2024: Methods in Molecular Biology
https://read.qxmd.com/read/38260674/interspecies-secreted-surfactants-induce-emergent-motility-in-pseudomonas-aeruginosa
#22
Delayna L Warrell, Tiffany M Zarrella, Christopher Machalek, Anupama Khare
In most natural environments, bacteria live in polymicrobial communities where secreted molecules from neighboring species alter bacterial behaviors including motility, but such interactions are understudied. Pseudomonas aeruginosa is a motile opportunistic pathogen that exists in diverse multispecies environments such as the soil and is frequently found in human wound and respiratory tract co-infections with other bacteria including Staphylococcus aureus . Here we show that P. aeruginosa can co-opt secreted molecules from other species for flagellar-based emergent motility...
January 4, 2024: bioRxiv
https://read.qxmd.com/read/38253648/comparative-assessment-of-phenolic-composition-profile-and-biological-activities-of-green-extract-and-conventional-extracts-of-salvia-sclarea
#23
JOURNAL ARTICLE
Mohammed Mansour Quradha, Mehmet Emin Duru, Selcuk Kucukaydin, Alfred Ngenge Tamfu, Mudassar Iqbal, Hamida Bibi, Rasool Khan, Ozgur Ceylan
In recent years, there have been an attempt to develop safe and environmental friendly solvents to replace conventional solvents, and use for extraction bioactive compounds from natural sources. A current investigation involved the preparation of green, methanolic, and ultrasonic extracts of S. sclarea, and compared their phenolic profiling using HPLC-DAD, antibacterial, antioxidant, and enzyme inhibition activities. The HPLC-DAD analysis revealed that Rosmarinic acid was the main content in all extracts, with Ellagic acid only present in the green extract...
January 22, 2024: Scientific Reports
https://read.qxmd.com/read/38200708/anti-biofilm-and-antivirulence-activities-of-1-2-6-tri-o-galloyl-%C3%AE-%C3%A1-glucose-against-proteus-penneri
#24
JOURNAL ARTICLE
Huan Jiang, Zhennan Wang, Ai-Qun Jia
AIMS: The present study investigated the anti-virulence and anti-biofilm effects of 1,2,6-tri-O-galloyl-β-ᴅ-glucose (TGG), isolated from Camellia nitidissima Chi flowers, on Proteus penneri ALK 1200. METHODS AND RESULTS: TGG was isolated from C. nitidissima Chi flowers using various chromatographic techniques. The milk plate assay, azocasein assay, and exopolysaccharides (EPS) inhibition assay revealed that TGG effectively inhibited the production of crucial virulence factors, including protease and EPS, in P...
January 10, 2024: Journal of Applied Microbiology
https://read.qxmd.com/read/38176270/antibiofilm-activity-of-lawsone-against-polymicrobial-enterohemorrhagic-escherichia-coli-o157-h7-and-candida-albicans-by-suppression-of-curli-production-and-hyphal-growth
#25
JOURNAL ARTICLE
Jin-Hyung Lee, Yong-Guy Kim, Jintae Lee
BACKGROUND: Most bacteria and fungi form biofilms that attach to living or abiotic surfaces. These biofilms diminish the efficacy of antimicrobial agents and contribute to chronic infections. Furthermore, multispecies biofilms composed of bacteria and fungi are often found at chronic infection sites. PURPOSE: In this study, lawsone (2‑hydroxy-1,4-naphthoquinone) and its parent 1,4-naphthoquinone were studied for antimicrobial and antibiofilm activities against single-species and multispecies biofilms of enterohemorrhagic Escherichia coli O157:H7 (EHEC) and Candida albicans...
December 19, 2023: Phytomedicine
https://read.qxmd.com/read/38162474/chemical-composition-and-quorum-sensing-inhibitory-effect-of-nepeta-curviflora-methanolic-extract-against-esbl-pseudomonas-aeruginosa
#26
JOURNAL ARTICLE
Haitham Qaralleh
OBJECTIVES: Bacterial biofilm is regarded as a significant threat to the production of safe food and the arise of antibiotic-resistant bacteria. The objective of this investigation is to evaluate the quorum sensing inhibitory effect of Nepeta curviflora methanolic extract. METHODS: The effectiveness of the leaves at sub-inhibitory concentrations of 2.5, 1.25, and 0.6 mg/mL on the virulence factors and biofilm formation of P. aeruginosa was evaluated. The effect of N...
December 31, 2023: Journal of Pharmacopuncture
https://read.qxmd.com/read/38161026/the-role-and-molecular-mechanism-of-flgk-gene-in-biological-properties-pathogenicity-and-virulence-genes-expression-of-aeromonas-hydrophila
#27
JOURNAL ARTICLE
Jiahui Lu, Chuanyu Xiong, Jinming Wei, Caijiang Xiong, Rui Long, Yongxiang Yu, Hua Ye, Eda Ozdemir, Yun Li, Ronghua Wu
Aeromonas hydrophila is a highly pathogenic aquatic resident bacterium that can cause co-morbidity in aquatic animals, waterfowl, poultry, and humans. Flagellum is the motility organ of bacteria important for bacterium tissue colonization and invasion. The flgK gene encodes a flagellar hook protein essential for normal flagellar formation. In order to explore the role of flgK in A. hydrophila, a flgK gene mutant strain of A. hydrophila (∆flgK-AH) was constructed using an efficient suicide plasmid-mediated homologous recombination method, and gene sequencing confirmed successful mutation of the flgK gene...
December 29, 2023: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38151670/efflux-pump-inhibition-based-screening-and-anti-infective-evaluation-of-punica-granatum-against-bacterial-pathogens
#28
JOURNAL ARTICLE
Samreen, Iqbal Ahmad, Shirjeel Ahmad Siddiqui, Anam Naseer, Aamir Nazir
Drug efflux pumps contribute to bacterial multidrug resistance (MDR), reducing antibiotic effectiveness and causing treatment failures. Besides their role in MDR, efflux pumps also assist in the transportation of quorum sensing (QS) signal molecules and increased the tolerance of biofilms. Recently, the search for efflux pump inhibitors from natural sources, including anti-infective plants, has gained attention as a potential therapy against drug-resistant bacteria. In this study, 19 traditional Indian medicinal plants were screened for their efflux pump inhibitory activity against Escherichia coli TGI...
December 27, 2023: Current Microbiology
https://read.qxmd.com/read/38139182/the-inactivation-of-the-putative-two-component-system-sensor-pa14_27940-increases-the-susceptibility-to-several-antibiotics-and-reduces-the-motility-of-pseudomonas-aeruginosa
#29
JOURNAL ARTICLE
Roberta Genova, Teresa Gil-Gil, Trinidad Cuesta, José Luis Martínez, Fernando Sanz-García
The identification of targets whose inactivation increases the activity of antibiotics helps to fight antibiotic resistance. Previous work showed that a transposon-insertion mutant in the gene PA14_27940 increases Pseudomonas aeruginosa susceptibility to aminoglycosides. Since polar effects may affect the phenotype, in the present work, we generated an in-frame PA14_27940 deletion mutant. A PA14_27940 deletion increased the susceptibility to aminoglycosides, tetracycline, tigecycline, erythromycin and fosfomycin...
December 11, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/38138556/phloretin-inhibits-quorum-sensing-and-biofilm-formation-in-serratia-marcescens
#30
JOURNAL ARTICLE
Yueheng Qi, Pengcheng Ji, Kunyuan Yin, Yi Zheng, Jiangxiu Niu, Aiqun Jia, Jinwei Zhou, Jingguo Li
This study investigated the antivirulence capacity and mechanism of apple-skin-derived phloretin against Serratia marcescens NJ01, a vegetable spoilage bacterium. At 0.5 to 2 mg/mL doses, phloretin considerably inhibited the secretion of acyl homoserine lactones (AHLs), indicating that phloretin disrupted quorum sensing (QS) in S. marcescens NJ01. The dysfunction of QS resulted in reduced biofilms and the decreased production of protease, prodigiosin, extracellular polysaccharides (EPSs), and swimming and swarming motilities...
December 13, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38138056/bovine-lactoferrin-and-hen-ovotransferrin-affect-virulence-factors-of-acute-hepatopancreatic-necrosis-disease-ahpnd-inducing-vibrio-parahaemolyticus-strains
#31
JOURNAL ARTICLE
Marieke Vandeputte, Margaux Verhaeghe, Lukas Willocx, Peter Bossier, Daisy Vanrompay
Acute Hepatopancreatic Necrosis Disease (AHPND), a highly destructive shrimp disease, has inflicted severe setbacks on the shrimp farming industry worldwide. As the use of antibiotics is discouraged due to emerging antibiotic-resistant bacteria and the pollution of ecosystems, there is a pressing demand for novel, sustainable alternatives. Hence, the influence of bovine lactoferrin (bLF) and hen ovotransferrin (OT), two natural antimicrobial proteins, on the growth of three AHPND-causing Vibrio parahaemolyticus ( Vp ) strains (M0904, TW01 and PV1) was examined...
December 2, 2023: Microorganisms
https://read.qxmd.com/read/38138037/roles-of-hcp2-a-hallmark-of-t6ss2-in-motility-adhesive-capacity-and-pathogenicity-of-vibrio-alginolyticus
#32
JOURNAL ARTICLE
Shuilong Wu, Jufen Tang, Bei Wang, Jia Cai, Jichang Jian
The type VI secretion system (T6SS) is a large secretory device, widely found in Gram-negative bacteria, which plays important roles in virulence, bacterial competition, and environmental adaptation. Vibrio alginolyticus ( V. alginolyticus ) is an opportunistic pathogen that causes vibriosis in aquaculture animals. V. alginolyticus possesses two type VI secretion systems (named the T6SS1 and T6SS2), but their functions remain largely unclear. In this paper, the roles of the core component of the T6SS2 cluster of V...
November 30, 2023: Microorganisms
https://read.qxmd.com/read/38133331/quorum-quenching-with-a-diffusible-signal-factor-analog-in-stenotrophomonas-maltophilia
#33
JOURNAL ARTICLE
Dafne Guillén-Navarro, Rosa González-Vázquez, Gloria León-Ávila, Silvia Giono-Cerezo
Stenotrophomonas maltophilia is a multidrug-resistant Gram-negative bacillus associated with nosocomial infections in intensive care units, and nowadays, its acquired resistance to trimethoprim-sulfamethoxazole (SXT) by sul genes within class 1 integrons is a worldwide health problem. Biofilm and motility are two of the major virulence factors in this bacterium and are auto-induced by the diffusible signal factor (DSF). In recent studies, retinoids have been used to inhibit (Quorum Quenching) these virulence factors and for their antimicrobial effect...
December 14, 2023: Pathogens
https://read.qxmd.com/read/38133262/differential-contribution-of-hydrogen-metabolism-to-proteus-mirabilis-fitness-during-single-species-and-polymicrobial-catheterized-urinary-tract-infection
#34
JOURNAL ARTICLE
Aimee L Brauer, Brian S Learman, Chelsie E Armbruster
Proteus mirabilis is a common uropathogen and a leading cause of catheter-associated urinary tract infections (CAUTIs), which are often polymicrobial. Through a genome-wide screen, we previously identified two [NiFe] hydrogenases as candidate fitness factors for P. mirabilis CAUTI: a Hyb-type Group 1c H2 -uptake hydrogenase and a Hyf-type Group 4a H2 -producing hydrogenase. In this study, we disrupted one gene of each system ( hyfE and hybC ) and also generated a double mutant to examine the contribution of flexible H2 metabolism to P...
November 22, 2023: Pathogens
https://read.qxmd.com/read/38094630/characterization-of-the-zinc-finger-%C3%AE-protein-hvo_0758-from-haloferax-volcanii-biological-roles-zinc-binding-and-nmr-solution-structure
#35
JOURNAL ARTICLE
Deniz Üresin, Dennis J Pyper, Andreas Borst, Lydia Hadjeras, Rick Gelhausen, Rolf Backofen, Cynthia Sharma, Harald Schwalbe, Jörg Soppa
It is increasingly recognized that very small proteins (μ-proteins) are ubiquitously found in all species of the three domains of life, and that they fulfill important functions. The halophilic archaeon Haloferax volcanii contains 282 μ-proteins of less than 70 amino acids. Notably, 43 of these contain two C(P)XCG motifs, suggesting their potential to complex a zinc ion. To explore the significance of these proteins, 16 genes encoding C(P)XCG proteins had been deleted, and the majority of mutants exhibited phenotypic differences to the wild-type...
2023: Frontiers in Microbiology
https://read.qxmd.com/read/38090073/management-of-virulence-in-pseudomonas-aeruginosa-and-serratia-marcescens-using-environmentally-friendly-titanium-dioxide-nanoparticles
#36
JOURNAL ARTICLE
Faizan Abul Qais, Mohammad Altaf, Iqbal Ahmad
Antimicrobial resistance (AMR), a condition in which the efficacy of antimicrobial drugs in fighting microorganisms is reduced, has become a global challenge. Multidrug resistance (MDR) has been developing in microorganisms, where they can resist multiple medications. In particular, there has been a rise in MDR as well as extensively drug-resistant (XDR) strains of Pseudomonas aeruginosa in some regions, with prevalence rates ranging from 15% to 30%. The application of nanotechnology ranges from diagnostics to drug-delivery systems, revolutionizing healthcare, and improving disease treatment...
December 8, 2023: RSC Advances
https://read.qxmd.com/read/38085021/a-widespread-methylotroph-acyl-homoserine-lactone-synthase-produces-a-new-quorum-sensing-signal-that-regulates-swarming-in-methylobacterium-fujisawaense
#37
JOURNAL ARTICLE
Mike Wallace, Dale A Cummings, Andrew G Roberts, Aaron W Puri
Bacteria known as pink-pigmented facultative methylotrophs colonize many diverse environments on earth, play an important role in the carbon cycle, and in some cases promote plant growth. However, little is known about how these organisms interact with each other and their environment. In this work, we identify one of the chemical signals commonly used by these bacteria and discover that this signal controls swarming motility in the pink-pigmented facultative methylotroph Methylobacterium fujisawaense DSM5686...
December 12, 2023: MBio
https://read.qxmd.com/read/38068694/exploring-the-differential-impact-of-salt-stress-on-root-colonization-adaptation-mechanisms-in-plant-growth-promoting-rhizobacteria
#38
JOURNAL ARTICLE
Lorena Del Rosario Cappellari, Pablo Cesar Bogino, Fiorela Nievas, Walter Giordano, Erika Banchio
Salinity inhibits plant growth by affecting physiological processes, but soil microorganisms like plant growth-promoting rhizobacteria (PGPR) can alleviate abiotic stress and enhance crop productivity. However, it should be noted that rhizobacteria employ different approaches to deal with salt stress conditions and successfully colonize roots. The objective of this study was to investigate the effect of salt stress on bacterial survival mechanisms such as mobility, biofilm formation, and the autoaggregation capacity of three plant growth-promoting strains: Pseudomonas putida SJ04, Pseudomonas simiae WCS417r, and Bacillus amyloliquefaciens GB03...
December 3, 2023: Plants (Basel, Switzerland)
https://read.qxmd.com/read/38062650/inhibition-of-biofilm-quorum-sensing-and-swarming-motility-in-pathogenic-bacteria-by-magnetite-manganese-ferrite-and-nickel-ferrite-nanoparticles
#39
JOURNAL ARTICLE
Yasemin İspirli Doğaç, Alfred Ngenge Tamfu, Selahattin Bozkurt, Mehmet Kayhan, Mustafa Teke, Ozgur Ceylan
Resistance to antibiotics by pathogenic bacteria constitutes a health burden and nanoparticles (NPs) are being developed as alternative and multipurpose antimicrobial substances. Magnetite (Fe3 O4 np), manganese ferrite (MnFe2 O4 np) and nickel ferrite (NiFe3 O4 np) NPs were synthesized and characterized using thermogravimetric analysis, transmission electron microscopy, Fourier transformed infra-red, and X-ray diffraction. The minimal inhibitory concentrations (MIC) ranged from 0.625 to 10 mg/mL against gram-positive (Staphylococcus aureus ATCC 25923 and Enterococcus faecalis ATCC 29212), gram-negative (Escherichia coli ATCC 25922 and Pseudomonas aeruginosa ATCC 27853) and candida (Candida albicans ATCC 10239 and Candida tropicalis ATCC 13803) species...
December 7, 2023: Biotechnology and Applied Biochemistry
https://read.qxmd.com/read/38059734/role-of-narl-gene-in-the-pathogenesis-of-salmonella-typhimurium
#40
JOURNAL ARTICLE
Pashupathi Mani, Swagatika Priyadarsini, Nikhil K Channabasappa, Pravas Ranjan Sahoo, Rohit Singh, Meeta Saxena, Vikramaditya Upmanyu, Ravi Kant Agrawal, Praveen Singh, Mohini Saini, Ajay Kumar
Salmonella Typhimurium (STM) is a facultative anaerobe and one of the causative agents of nontyphoidal salmonellosis (NTS). Its anaerobic metabolism is enabled under the hypoxic environment that is encountered inside macrophages and the gut lumen of the host. In both of these niches, free radicals and oxidative intermediates are released by neutrophils as an inflammatory response. These chemical species further undergo reactions to produce nitrate, which is preferably taken up by STM as an electron acceptor in the absence of oxygen...
December 7, 2023: Journal of Basic Microbiology
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