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https://www.readbyqxmd.com/read/29914989/ompr-regulator-of-burkholderia-multivorans-controls-mucoid-to-nonmucoid-transition-and-other-cell-envelope-properties-associated-with-persistence-in-the-cystic-fibrosis-lung
#1
Inês N Silva, Filipa D Pessoa, Marcelo J Ramires, Mário R Santos, Jörg D Becker, Vaughn S Cooper, Leonilde M Moreira
Bacteria from the Burkholderia cepacia complex grow in different natural and man-made environments and are feared opportunistic pathogens that cause chronic respiratory infections in cystic fibrosis patients. Previous studies showed that Burkholderia mucoid clinical isolates grown under stress conditions give rise to nonmucoid variants devoid of the exopolysaccharide cepacian. Here, we have determined that a major cause of the nonmucoid morphotype involves nonsynonymous mutations and small indels in the ompR gene encoding a response regulator of a two-component regulatory system...
June 18, 2018: Journal of Bacteriology
https://www.readbyqxmd.com/read/29902594/characterization-of-clinically-relevant-model-bacterial-strains-of-pseudomonas-aeruginosa-for-anti-biofilm-testing-of-materials
#2
Olena Rzhepishevska, Nataliia Limanska, Mykola Galkin, Alicia Lacoma, Margaretha Lundquist, Dmytro Sokol, Shoghik Hakobyan, Anders Sjöstedt, Cristina Prat, Madeleine Ramstedt
There is a great interest in developing novel anti-biofilm materials in order to decrease medical device-associated bacterial infections causing morbidity and high healthcare costs. However, the testing of novel materials is often done using bacterial lab strains that may not exhibit the same phenotype as clinically relevant strains infecting medical devices. Furthermore, no consensus of strain selection exists in the field, making results very difficult to compare between studies. In this work, 19 clinical isolates of Pseudomonas aeruginosa originating from intubated patients in an intensive care unit have been characterized and compared to the lab reference strain PAO1 and a rmlC lipopolysaccharide mutant of PAO1...
June 11, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29892084/swarming-motility-and-biofilm-formation-of-paenibacillus-larvae-the-etiological-agent-of-american-foulbrood-of-honey-bees-apis-mellifera
#3
Anne Fünfhaus, Josefine Göbel, Julia Ebeling, Henriette Knispel, Eva Garcia-Gonzalez, Elke Genersch
American Foulbrood is a worldwide distributed, fatal disease of the brood of the Western honey bee (Apis mellifera). The causative agent of this fatal brood disease is the Gram-positive, spore-forming bacterium Paenibacillus larvae, which can be classified into four different genotypes (ERIC I-IV), with ERIC I and II being the ones isolated from contemporary AFB outbreaks. P. larvae is a peritrichously flagellated bacterium and, hence, we hypothesized that P. larvae is capable of coordinated and cooperative multicellular behaviors like swarming motility and biofilm formation...
June 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29864697/in-vitro-and-in-vivo-effect-of-2-6-di-tert-butyl-4-methylphenol-as-an-antibiofilm-agent-against-quorum-sensing-mediated-biofilm-formation-of-vibrio-spp
#4
Sivasubramanian Santhakumari, Rengarajan Jayakumar, Ravichandran Logalakshmi, Narayanan Marimuthu Prabhu, Abdul Kuthus Abdul Nazar, Shunmugiah Karutha Pandian, Arumugam Veera Ravi
This study unveils the in vitro and in vivo antibiofilm potential of 2,6-Di-tert-butyl-4-methylphenol (DTBMP) from Chroococcus turgidus against Vibrio spp. In the preliminary study, cell free culture supernatant (CFCS) of C. turgidus inhibited the violacein production in biomarker strain Chromobacterium violaceum and its mutant strain CV026 in a dose dependent manner. The effective biofilm inhibitory concentration (BIC) of pure compound DTBMP from C. turgidus was identified as 250 μg/ml concentration in tested Vibrio species...
May 25, 2018: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29807134/quorum-sensing-signals-and-related-virulence-inhibition-of-pseudomonas-aeruginosa-by-a-potential-probiotic-strain-s-organic-acid
#5
Merve Eylul Kiymaci, Nurten Altanlar, Mehmet Gumustas, Sibel A Ozkan, Ahmet Akin
Studies conducted in recent years show that pathogen bacteria are not asocial assets and they use the cell to cell communication mechanism called quorum sensing that depends on population density to adapt changing environmental conditions. This mechanism is coordinate gene expression of various bacterial factors like bioluminescence, antibiotic biosynthesis, plasmid conjugation and virulence. Bacteria communicate with each other by producing signal molecules and regulate the production of virulence factors that have importance in the pathogenity formation...
May 25, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29801413/transcriptomic-profiling-suggests-that-promysalin-alters-metabolic-flux-motility-and-iron-regulation-in-pseudomonas-putida-kt2440
#6
Krista Giglio, Colleen Keohane, Paul Stodghill, Andrew Steele, Christian Fetzer, Stephan Sieber, Melanie Filiatrault, William M Wuest
Promysalin, a secondary metabolite produced by P. putida RW10S1, is a narrow-spectrum antibiotic that targets P. aeruginosa over other Pseudomonas spp. P. putida KT2440, a non-producing strain, displays increased swarming motility and decreased pyoverdine production in the presence of exogenous promysalin. Herein, proteomic and transcriptomic experiments were used to provide insight about how promysalin elicits responses in PPKT2440 and rationalize its species-selectivity. RNA-sequencing results suggest that promysalin affects PPKT2440 by 1) increasing swarming in a flagella-independent manner; 2) causing cells to behave as if they were experiencing an iron-deficient environment, and 3) shifting metabolism away from glucose conversion to pyruvate via the Entner-Doudoroff pathway...
May 25, 2018: ACS Infectious Diseases
https://www.readbyqxmd.com/read/29773197/efficient-zinc-uptake-is-critical-for-the-ability-of-pseudomonas-aeruginosa-to-express-virulence-traits-and-colonize-the-human-lung
#7
Maria Chiara Mastropasqua, Iain Lamont, Lois W Martin, David W Reid, Melania D'Orazio, Andrea Battistoni
We have recently shown that Pseudomonas aeruginosa, an opportunistic pathogen that chronically infects the lungs of patients with cystic fibrosis (CF) and other forms of lung disease, is extremely efficient in recruiting zinc from the environment and that this capability is required for its ability to cause acute lung infections in mice. To verify that P. aeruginosa faces zinc shortage when colonizing the lungs of human patients, we analyzed the expression of three genes that are highly induced under conditions of zinc deficiency (zrmA, dksA2 and rpmE2), in bacteria in the sputum of patients with inflammatory lung disease...
July 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29758033/phylogenetic-relationships-biofilm-formation-motility-antibiotic-resistance-and-extended-virulence-genotypes-among-escherichia-coli-strains-from-women-with-community-onset-primitive-acute-pyelonephritis
#8
Arianna Pompilio, Valentina Crocetta, Vincenzo Savini, Dezemona Petrelli, Marta Di Nicola, Silvia Bucco, Luigi Amoroso, Mario Bonomini, Giovanni Di Bonaventura
The present work set out to search for a virulence repertoire distinctive for Escherichia coli causing primitive acute pyelonephritis (APN). To this end, the virulence potential of 18 E. coli APN strains was genotypically and phenotypically assessed, comparatively with 19 strains causing recurrent cystitis (RC), and 16 clinically not significant (control, CO) strains. Most of the strains belong to phylogenetic group B1 (69.8%; p<0.01), and APN strains showed unique features, which are the presence of phylogroup A, and the absence of phylogroup B2 and non-typeable strains...
2018: PloS One
https://www.readbyqxmd.com/read/29751512/screening-of-natural-product-derivatives-identifies-two-structurally-related-flavonoids-as-potent-quorum-sensing-inhibitors-against-gram-negative-bacteria
#9
Suvi Manner, Adyary Fallarero
Owing to the failure of conventional antibiotics in biofilm control, alternative approaches are urgently needed. Inhibition of quorum sensing (QS) represents an attractive target since it is involved in several processes essential for biofilm formation. In this study, a compound library of natural product derivatives ( n = 3040) was screened for anti-quorum sensing activity using Chromobacterium violaceum as reporter bacteria. Screening assays, based on QS-mediated violacein production and viability, were performed in parallel to identify non-bactericidal QS inhibitors (QSIs)...
May 3, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29733941/anti-quorum-sensing-activity-toxicity-in-zebrafish-danio-rerio-embryos-and-phytochemical-characterization-of-trapa-natans-leaf-extracts
#10
Ivana Aleksic, Petar Ristivojevic, Aleksandar Pavic, Ivana Radojević, Ljiljana R Čomić, Branka Vasiljevic, Dejan Opsenica, Dušanka Milojković-Opsenica, Lidija Senerovic
ETHNOPHARMACOLOGICAL RELEVANCE: Trapa natans L. (water chestnut or water caltrop) is a widespread aquatic plant, which has been cultivated for food and traditional medicine since ancient times. Pharmacological studies showed that water chestnut exhibits the wide range of biological activities, such as antimicrobial, antioxidative, analgesic, anti-inflammatory, as well as antiulcer. AIMOF THE STUDY: Evaluation of anti-virulence potential and toxicity of T. natans methanol (TnM), acetone (TnA) and ethyl acetate (TnEA) leaf extracts...
May 4, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29733749/real-time-dynamics-of-neutrophil-clustering-in-response-to-phototoxicity-induced-cell-death-and-tissue-damage-in-mouse-ear-dermis
#11
Sang A Park, Young Ho Choe, Eunji Park, Young-Min Hyun
Neutrophils are highly motile innate immune cells; they actively migrate in response to inflammatory signals. Using two-photon intravital microscopy, we discovered that neutrophils form stable clusters upon phototoxicity at a certain threshold. Without significant damage to the collagen structure of mouse dermis, neutrophils aggregated together with nearby neutrophils. Surprisingly, this in situ neutrophil clustering resulted in rigorous changes of migratory direction. The density of residing neutrophils was also a critical factor affecting clustering...
May 7, 2018: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/29694695/quorum-sensing-inhibitor-potential-of-trans-anethole-aganist-pseudomonas-aeruginosa
#12
Demet Hançer Aydemir, Gülşah Çifçi, Viktorya Aviyente, Gülgün Boşgelmez-Tinaz
AIMS: Quorum sensing (QS) is a cell-cell communication system used by a broad spectrum of pathogenic bacteria to control the expression of their virulence genes. The interruption of QS systems of pathogenic bacteria has been considered as a novel way to fight bacterial diseases. In this study, trans-anethole, the main component of anise (Pimpinella anisum) oil was examined for its QS inhibitor (QSI) potential in an attempt to identify novel QSI compound effective against opportunistic pathogen P...
April 25, 2018: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29690523/the-effects-of-chinese-herbal-medicines-on-the-quorum-sensing-regulated-virulence-in-pseudomonas-aeruginosa-pao1
#13
Yee Meng Chong, Kah Yan How, Wai Fong Yin, Kok Gan Chan
The quorum sensing (QS) system has been used by many opportunistic pathogenic bacteria to coordinate their virulence determinants in relation to cell-population density. As antibiotic-resistant bacteria are on the rise, interference with QS has been regarded as a novel way to control bacterial infections. As such, many plant-based natural products have been widely explored for their therapeutic roles. These natural products may contain anti-QS compounds that could block QS signals generation or transmission to combat QS pathogens...
April 21, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29684116/biofilm-forming-ability-and-infection-potential-of-pseudomonas-aeruginosa-strains-isolated-from-animals-and-humans
#14
Dusan Milivojevic, Neven Šumonja, Strahinja Medic, Aleksandar Pavic, Ivana Moric, Branka Vasiljevic, Lidija Senerovic, Jasmina Nikodinovic-Runic
Pseudomonas aeruginosa has been amongst the top 10 'superbugs' worldwide and is causing infections with poor outcomes in both humans and animals. From 202 P. aeruginosa isolates (n = 121 animal and n = 81 human), 40 were selected on the basis of biofilm-forming ability and were comparatively characterized in terms of virulence determinants to the type strain P. aeruginosa PAO1. Biofilm formation, pyocyanin and hemolysin production, and bacterial motility patterns were compared with the ability to kill human cell line A549 in vitro...
June 1, 2018: Pathogens and Disease
https://www.readbyqxmd.com/read/29682537/the-potential-virulence-factors-of-providencia-stuartii-motility-adherence-and-invasion
#15
Naziia Kurmasheva, Vyacheslav Vorobiev, Margarita Sharipova, Tatyana Efremova, Ayslu Mardanova
Providencia stuartii is the most common Providencia species capable of causing human infections. Currently P. stuartii is involved in high incidence of urinary tract infections in catheterized patients. The ability of bacteria to swarm on semisolid (viscous) surfaces and adhere to and invade host cells determines the specificity of the disease pathogenesis and its therapy. In the present study we demonstrated morphological changes of P. stuartii NK cells during migration on the viscous medium and discussed adhesive and invasive properties utilizing the HeLa-M cell line as a host model...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29669887/pseudomonas-aeruginosa-gsha-mutant-is-defective-in-biofilm-formation-swarming-and-pyocyanin-production
#16
Tricia A Van Laar, Saika Esani, Tyler J Birges, Bethany Hazen, Jason M Thomas, Mamta Rawat
Pseudomonas aeruginosa is a ubiquitous Gram-negative bacterium that can cause severe opportunistic infections. The principal redox buffer employed by this organism is glutathione (GSH). To assess the role of GSH in the virulence of P. aeruginosa , a number of analyses were performed using a mutant strain deficient in gshA , which does not produce GSH. The mutant strain exhibited a growth delay in minimal medium compared to the wild-type strain. Furthermore, the gshA mutant was defective in biofilm and persister cell formation and in swimming and swarming motility and produced reduced levels of pyocyanin, a key virulence factor...
April 25, 2018: MSphere
https://www.readbyqxmd.com/read/29653054/one-enzyme-to-build-them-all-ring-size-engineered-siderophores-inhibit-the-swarming-motility-of-vibrio
#17
Sina Rütschlin, Sandra Gunesch, Thomas Böttcher
Bacteria compete for ferric iron by producing siderophores, and some microbes engage in piracy by scavenging siderophores of their competitors. The macrocyclic hydroxamate siderophore avaroferrin of Shewanella algae inhibits swarming of Vibrio alginolyticus by evading this piracy. Avaroferrin, as well as related putrebactin and bisucaberin, are produced by the IucC-like synthetases AvbD, PubC, and BibCC . Here, we have established that they are capable of synthesizing not only their native product but also other siderophores...
May 18, 2018: ACS Chemical Biology
https://www.readbyqxmd.com/read/29629859/the-clpy-clpq-protease-regulates-multicellular-development-in-bacillus-subtilis
#18
Yiyang Yu, Fang Yan, Yinghao He, Yuxuan Qin, Yun Chen, Yunrong Chai, Jian-Hua Guo
ATP-dependent proteases play essential roles in both protein quality control and the regulation of protein activities in bacteria. ClpYQ (also known as HslVU) is one of several highly conserved ATP-dependent proteases in bacteria. The regulation and biological function of ClpYQ have been well studied in Gram-negative bacteria, but are poorly understood in Gram-positive species. In this study, we showed that in the Gram-positive bacterium Bacillus subtilis, the ΔclpYQ deletion mutant formed early and robust biofilms, while swarming motility was severely impaired...
May 2018: Microbiology
https://www.readbyqxmd.com/read/29619040/oxygen-availability-influences-expression-of-dickeya-solani-genes-associated-with-virulence-in-potato-solanum-tuberosum-l-and-chicory-cichorium-intybus-l
#19
Wioletta Lisicka, Jakub Fikowicz-Krosko, Sylwia Jafra, Magdalena Narajczyk, Paulina Czaplewska, Robert Czajkowski
Dickeya solani is a Gram-negative necrotrophic, plant pathogenic bacterium able to cause symptoms in a variety of plant species worldwide. As a facultative anaerobe, D. solani is able to infect hosts under a broad range of oxygen concentrations found in plant environments. However, little is known about oxygen-dependent gene expression in Dickeya spp. that might contribute to its success as a pathogen. Using a Tn5 transposon, harboring a promoterless gusA reporter gene, 146 mutants of D. solani IPO2222 were identified that exhibited oxygen-regulated expression of the gene into which the insertion had occurred...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29515658/chlortetracycline-and-florfenicol-induce-expression-of-genes-associated-with-pathogenicity-in-multidrug-resistant-salmonella-enterica-serovar-typhimurium
#20
Devin B Holman, Shawn M D Bearson, Bradley L Bearson, Brian W Brunelle
Background: Multidrug-resistant (MDR) Salmonella enterica serovar Typhimurium ( S . Typhimurium) is a serious public health threat as infections caused by these strains are more difficult and expensive to treat. Livestock serve as a reservoir for MDR Salmonella , and the antibiotics chlortetracycline and florfenicol are frequently administrated to food-producing animals to treat and prevent various diseases. Therefore, we evaluated the response of MDR S . Typhimurium after exposure to these two antibiotics...
2018: Gut Pathogens
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