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https://www.readbyqxmd.com/read/28637123/inhibition-of-swarming-motility-of-pseudomonas-aeruginosa-by-methanol-extracts-of-alpinia-officinarum-hance-and-cinnamomum-tamala-t-nees-and-eberm
#1
Divya Lakshmanan, Jishudas Nanda, K Jeevaratnam
Bacterial drug resistance is a challenge in clinical settings, especially in countries like India. Hence, discovery of novel alternative therapeutics has become a necessity in the fight against drug resistance. Compounds that inhibit bacterial virulence properties form new therapeutic alternatives. Pseudomonas aeruginosa is an opportunistic, nosocomial pathogen that infects immune-compromised patients. Swarming motility is an important virulence property of Pseudomonas which aids it in reaching host cells under nutrient limiting conditions...
June 15, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28613253/terpenoids-from-platostoma-rotundifolium-briq-a-j-paton-alter-the-expression-of-quorum-sensing-related-virulence-factors-and-the-formation-of-biofilm-in-pseudomonas-aeruginosa-pao1
#2
Tsiry Rasamiravaka, Jérémie Ngezahayo, Laurent Pottier, Sofia Oliveira Ribeiro, Florence Souard, Léonard Hari, Caroline Stévigny, Mondher El Jaziri, Pierre Duez
Platostoma rotundifolium (Briq.) A. J. Paton aerial parts are widely used in Burundi traditional medicine to treat infectious diseases. In order to investigate their probable antibacterial activities, crude extracts from P. rotundifolium were assessed for their bactericidal and anti-virulence properties against an opportunistic bacterial model, Pseudomonas aeruginosa PAO1. Whereas none of the tested extracts exert bacteriostatic and/or bactericidal proprieties, the ethyl acetate and dichloromethane extracts exhibit anti-virulence properties against Pseudomonas aeruginosa PAO1 characterized by an alteration in quorum sensing gene expression and biofilm formation without affecting bacterial viability...
June 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28607157/anaerobic-cysteine-degradation-and-potential-metabolic-coordination-in-salmonella-enterica-and-escherichia-coli
#3
Melissa Loddeke, Barbara Schneider, Tamiko Oguri, Iti Mehta, Zhenyu Xuan, Larry Reitzer
Salmonella enterica has two CutR-activated enzymes that degrade cysteine: the aerobic CdsH and an unidentified anaerobic enzyme; E. coli only has the latter. To identify the anaerobic enzyme, transcript profiling was performed from E. coli without cutR and with overexpressed cutR 37 genes showed at least a five-fold change in expression, and the cutPA (formerly yhaOM) operon had the greatest differential. Homology suggested that CutP and CutA are a cysteine transporter and an iron-sulfur-containing cysteine desulfidase, respectively...
June 12, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28593349/transcriptomic-analysis-of-the-swarm-motility-phenotype-of-salmonella-enterica-serovar-typhimurium-mutant-defective-in-periplasmic-glucan-synthesis
#4
Arvind A Bhagwat, Lynn Young, Allen D Smith, Medha Bhagwat
Movement of food-borne pathogens on moist surfaces enables them to migrate towards more favorable niches and facilitate their survival for extended periods of time. Salmonella enterica serovar Typhimurium mutants defective in Osmoregulated periplasmic glucans (OPG) synthesis are unable to exhibit motility on moist surfaces (swarming); however, their mobility in liquid (swim motility) remains unaffected. In order to understand the role of OPG in swarm motility, transcriptomic analysis was performed using cells growing on a moist agar surface...
June 8, 2017: Current Microbiology
https://www.readbyqxmd.com/read/28591665/inhibition-of-pseudomonas-aeruginosa-quorum-sensing-by-subinhibitory-concentrations-of-curcumin-with-gentamicin-and-azithromycin
#5
Shahin Bahari, Habib Zeighami, Hesam Mirshahabi, Shekoufeh Roudashti, Fakhri Haghi
OBJECTIVES: Pseudomonas aeruginosa quorum sensing (QS) circuits regulate virulence factors and co-ordinate bacterial pathogenicity. This study aimed to investigate the inhibitory activity of subinhibitory concentrations of curcumin with azithromycin and gentamicin against P. aeruginosa QS-related genes and virulence factors. METHODS: The minimum inhibitory concentrations (MICs) and synergistic activity of curcumin with azithromycin and gentamicin against P. aeruginosa PAO1 were determined using broth microdilution and checkerboard titration methods, respectively...
June 4, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28567253/photomodulation-of-bacterial-growth-and-biofilm-formation-using-carbohydrate-based-surfactants
#6
Yingxue Hu, Wenyue Zou, Villy Julita, Rajesh Ramanathan, Rico F Tabor, Reece Nixon-Luke, Gary Bryant, Vipul Bansal, Brendan L Wilkinson
Naturally occurring and synthetic carbohydrate amphiphiles have emerged as a promising class of antimicrobial and antiadhesive agents that act through a number of dynamic and often poorly understood mechanisms. In this paper, we provide the first report on the application of azobenzene trans-cis photoisomerization for effecting spatial and temporal control over bacterial growth and biofilm formation using carbohydrate-based surfactants. Photocontrollable surface tension studies and small angle neutron scattering (SANS) revealed the diverse geometries and dimensions of self-assemblies (micelles) made possible through variation of the head group and UV-visible light irradiation...
November 1, 2016: Chemical Science
https://www.readbyqxmd.com/read/28559296/cysteine-biosynthesis-controls-serratia-marcescens-phospholipase-activity
#7
Mark T Anderson, Lindsay A Mitchell, Harry L T Mobley
Serratia marcescens causes healthcare-associated opportunistic infections that can be difficult to treat due to a high incidence of antibiotic resistance. One of the many secreted proteins of S. marcescens is the PhlA phospholipase enzyme. Genes involved in the production and secretion of PhlA were identified by screening a transposon insertion library for phospholipase-deficient mutants on phosphatidylcholine-containing medium. Mutations were identified in four genes (cyaA, crp, fliJ and fliP) that are involved in the flagellar-dependent PhlA secretion pathway...
May 30, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28554619/swarm-motility-inhibitory-and-antioxidant-activities-of-pomegranate-peel-processed-under-three-drying-conditions
#8
K M Maria John, Arvind A Bhagwat, Devanand L Luthria
During processing of ready-to-eat fresh fruits, large amounts of peel and seeds are discarded as waste. Pomegranate (Punicagranatum) peels contain high amounts of bioactive compounds which inhibit migration of Salmonella on wet surfaces. The metabolic distribution of bioactives in pomegranate peel, inner membrane, and edible aril portion was investigated under three different drying conditions along with the anti-swarming activity against Citrobacter rodentium. Based on the multivariate analysis, 29 metabolites discriminated the pomegranate peel, inner membrane, and edible aril portion, as well as the three different drying methods...
November 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28552808/phytochemical-composition-anti-biofilm-and-anti-quorum-sensing-potential-of-fruit-stem-and-leaves-of-salvadora-persica-l-methanolic-extracts
#9
Emira Noumi, Mejdi Snoussi, Abderrahmen Merghni, Filomena Nazzaro, Guillermo Quindós, Gültekin Akdamar, Maha Mastouri, Abdulbasset Al-Sieni, Ozgur Ceylan
Emergence of antibiotic resistance among pathogenic bacteria encourages us to search for new molecules as an alternative treatment. The aim of this study was to evaluate the antiquorum sensing (anti-QS) and antibiofilm potential of Salvadora persica L. methanolic extracts to prevent the infections due to Staphylococcus as an alternate to antibiotics. The methanolic extracts of S. persica L. fruit, leaves and stems was assessed for their activity in inhibiting QS-depedent phenomenon such as violacein pigment production in Chromobacterium violaceum, swarming motility of Pseudomonas aeruginosa PAO1 and biofilm formation in oral Staphylococcus strains on polymethylmetacrylate (PMMA)...
May 26, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28550060/surface-sensing-for-flagellar-gene-expression-on-solid-media-in-paenibacillus-sp-naist15-1
#10
Kazuo Kobayashi, Yu Kanesaki, Hirofumi Yoshikawa
A rhizosphere Gram-positive bacterial isolate, Paenibacillus sp. NAIST15-1, exhibits intriguing motility behavior on hard agar media. Paenibacillus sp. shows increased transcription of flagellar genes and hyperflagellation when transferred from liquid to solid media. Hyperflagellated cells form wandering colonies that are capable of moving around on the surface of media containing ≥1.5% agar. Transposon mutagenesis was used to identify genes critical for motility. In addition to flagellar genes, this mutagenesis identified five non-flagellar structural genes that were important for motility...
May 26, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28536559/new-functions-and-subcellular-localization-patterns-of-c-di-gmp-components-ggdef-domain-proteins-in-b-subtilis
#11
Patricia Bedrunka, Peter L Graumann
The universal and pleiotropic cyclic dinucleotide second messenger c-di-GMP is most prominently known to inversely regulate planktonic and sessile lifestyles of Gram-negative species. In the Gram-positive model organism Bacillus subtilis, intracellular c-di-GMP levels are modulated by a concise set of three diguanylate cylases (DgcK, DgcP, DgcW) and one phosphodiesterase (PdeH). Two recent studies have reported the negative influence of the c-di-GMP receptor DgrA (PilZ domain protein) on swarming motility indicating a conserved role of this second messenger across the bacterial domain...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28536199/active-depinning-of-bacterial-droplets-the-collective-surfing-of-bacillus-subtilis
#12
Marc Hennes, Julien Tailleur, Gaëlle Charron, Adrian Daerr
How systems are endowed with migration capacity is a fascinating question with implications ranging from the design of novel active systems to the control of microbial populations. Bacteria, which can be found in a variety of environments, have developed among the richest set of locomotion mechanisms both at the microscopic and collective levels. Here, we uncover, experimentally, a mode of collective bacterial motility in humid environment through the depinning of bacterial droplets. Although capillary forces are notoriously enormous at the bacterial scale, even capable of pinning water droplets of millimetric size on inclined surfaces, we show that bacteria are able to harness a variety of mechanisms to unpin contact lines, hence inducing a collective slipping of the colony across the surface...
June 6, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28527130/pulse-generation-in-the-quorum-machinery-of-pseudomonas-aeruginosa
#13
Cicik Alfiniyah, Martin A Bees, A Jamie Wood
Pseudomonas aeruginosa is a Gram-negative bacterium that is responsible for a wide range of infections in humans. Colonies employ quorum sensing (QS) to coordinate gene expression, including for virulence factors, swarming motility and complex social traits. The QS signalling system of P. aeruginosa is known to involve multiple control components, notably the las, rhl and pqs systems. In this paper, we examine the las system and, in particular, the repressive interaction of rsaL, an embedded small regulative protein, employing recent biochemical information to aid model construction...
May 19, 2017: Bulletin of Mathematical Biology
https://www.readbyqxmd.com/read/28522292/cross-talk-between-bacterial-two-component-systems-drives-stepwise-regulation-of-flagellar-biosynthesis-in-swarming-development
#14
Chia-Fong Wei, Yu-Huan Tsai, Sheng-Hui Tsai, Chuan-Sheng Lin, Chih-Jung Chang, Chia-Chen Lu, Hsiou-Chen Huang, Hsin-Chih Lai
Swarming motility is a mode of bacterial movement over a solid surface driven by rotating flagella in a coordinated manner. Bacteria can use two-component system (TCS), which typically comprises a sensor kinase and a specific cognate response regulator, to properly react to environmental changes. We previously showed that the TCS RssAB suppresses flagellar biosynthesis master regulator flhDC specifically in swarming lag phase to control surface migration timing without affecting expansion rate in Serratia marcescens swarming development...
July 15, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28513418/flagellar-expression-in-clinical-isolates-of-non-typeable-haemophilus-influenzae
#15
Alejandro Carabarin-Lima, Patricia Lozano-Zarain, Miguel Castañeda-Lucio, Claudia Fabiola Martínez de la Peña, Julieta Martinez-Garcia, Norarizbeth Lara Flores, Elías Campos de la Cruz, Sirenia González-Posos, Rosa Del Carmen Rocha-Gracia
PURPOSE: Haemophilus influenzae is a commensal organism found in the upper respiratory tract of humans. When H. influenzae becomes a pathogen, these bacteria can move out of their commensal niche and cause multiple respiratory tract diseases such as otitis media, sinusitis, conjunctivitis and bronchitis in children, and chronic obstructive pulmonary disease in adults. However, H. influenzae is currently considered a non-flagellate bacterium. METHODOLOGY AND RESULTS: In this study, 90 clinical isolates of H...
May 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28504816/virulence-factors-and-antimicrobial-resistance-in-environmental-strains-of-vibrio-alginolyticus
#16
Marcos F Hernández-Robles, Ana K Álvarez-Contreras, Patricia Juárez-García, Iván Natividad-Bonifacio, Everardo Curiel-Quesada, Carlos Vázquez-Salinas, Elsa I Quiñones-Ramírez
Vibrio alginolyticus has acquired increasing importance because this microorganism may be pathogenic to aquatic animals and humans. It has been reported that some V. alginolyticus strains carry virulence genes derived from pathogenic V. cholerae and V. parahaemolyticus strains. In this work V. alginolyticus was isolated from oyster samples acquired from a food-market in Mexico City. Thirty isolates were identified as V. alginolitycus. Strains showed β-haemolysis and proteolytic activity and produced a capsule...
December 2016: International Microbiology: the Official Journal of the Spanish Society for Microbiology
https://www.readbyqxmd.com/read/28500044/rpon-%C3%AF-54-is-required-for-floc-formation-but-not-for-extracellular-polysaccharide-biosynthesis-in-a-floc-forming-aquincola-tertiaricarbonis-strain
#17
Dianzhen Yu, Ming Xia, Liping Zhang, Yulong Song, You Duan, Tong Yuan, Minjie Yao, Liyou Wu, Chunyuan Tian, Zhenbin Wu, Xiangzhen Li, Jizhong Zhou, Dongru Qiu
Some bacteria are capable of forming flocs in which bacterial cells are self-flocculated by secreted extracellular polysaccharides and other biopolymers. The floc-forming bacteria play a central role in activated sludge, which has been widely utilized for the treatment of municipal sewage and industrial wastewater. Here we use a floc-forming bacterium, Aquincola tertiaricarbonis RN12, as a model to explore the biosynthesis of EPS and the regulation of floc-formation. A large gene cluster for exopolysaccharide biosynthesis and a gene encoding the alternative sigma factor RpoN1, one of the four paralogues, have been identified in the floc-formation-deficient mutants generated by transposon mutagenesis and the gene functions have been further confirmed by genetic complementation analyses...
May 12, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28484444/leaf-extracts-of-mangifera-indica-l-inhibit-quorum-sensing-regulated-production-of-virulence-factors-and-biofilm-in-test-bacteria
#18
Fohad M Husain, Iqbal Ahmad, Abdullah S Al-Thubiani, Hussein H Abulreesh, Ibrahim M AlHazza, Farrukh Aqil
Quorum sensing (QS) is a global gene regulatory mechanism in bacteria for various traits including virulence factors. Disabling QS system with anti-infective agent is considered as a potential strategy to prevent bacterial infection. Mangifera indica L. (mango) has been shown to possess various biological activities including anti-QS. This study investigates the efficacy of leaf extracts on QS-regulated virulence factors and biofilm formation in Gram negative pathogens. Mango leaf (ML) extract was tested for QS inhibition and QS-regulated virulence factors using various indicator strains...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28458663/h-ns-mutation-mediated-crispr-cas-activation-inhibits-phage-release-and-toxin-production-of-escherichia-coli-stx2-phage-lysogen
#19
Qiang Fu, Shiyu Li, Zhaofei Wang, Wenya Shan, Jingjiao Ma, Yuqiang Cheng, Hengan Wang, Yaxian Yan, Jianhe Sun
Shiga toxin-converting bacteriophages (Stx phages) carry the stx gene and convert nonpathogenic bacterial strains into Shiga toxin-producing bacteria. There is limited understanding of the effect that an Escherichia coli (E. coli) clustered regularly interspaced short palindromic repeats (CRISPR)-Cas adaptive immune system has on Stx phage lysogen. We investigated heat-stable nucleoid-structuring (H-NS) mutation-mediated CRISPR-Cas activation and its effect on E. coli Stx2 phage lysogen. The Δhns mutant (MG1655Δhns) of the E...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28452529/effect-of-cell-aspect-ratio-on-swarming-bacteria
#20
Bella Ilkanaiv, Daniel B Kearns, Gil Ariel, Avraham Be'er
Swarming bacteria collectively migrate on surfaces using flagella, forming dynamic whirls and jets that consist of millions of individuals. Because some swarming bacteria elongate prior to actual motion, cell aspect ratio may play a significant role in the collective dynamics. Extensive research on self-propelled rodlike particles confirms that elongation promotes alignment, strongly affecting the dynamics. Here, we study experimentally the collective dynamics of variants of swarming Bacillus subtilis that differ in length...
April 14, 2017: Physical Review Letters
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