Gorka Larrinaga, Asier Valdivia, Inés Arrieta-Aguirre, Jon Danel Solano-Iturri, Aitziber Ugalde-Olano, Ana Loizaga-Iriarte, Aida Santos-Martín, Amparo Pérez-Fernández, Javier C Angulo, José I López
Renal cell carcinoma (RCC) ranks among the most prevalent malignancies in Western countries, marked by its notable heterogeneity, which contributes to an unpredictable clinical trajectory. The insufficiency of dependable biomarkers adds complexity to assessing this tumor progression. Imbalances of several components of the intrarenal renin-angiotensin system (iRAS) significantly impact patient prognoses and responses to first-line immunotherapies. In this study, we analyzed the immunohistochemical expression of the Mas-related G-protein-coupled receptor D (MrgD), which recognizes the novel RAS peptide alamandine (ALA), in a series of 87 clear cell renal cell (CCRCCs), 19 papillary (PRCC), 7 chromophobe (ChRCC) renal cell carcinomas, and 11 renal oncocytomas (RO)...
January 25, 2024: International Journal of Molecular Sciences