keyword
https://read.qxmd.com/read/38545789/knocking-out-sodium-glucose-linked-transporter-5-prevents-fructose-induced-renal-oxidative-stress-and-salt-sensitive-hypertension
#1
JOURNAL ARTICLE
Beau R Forester, Ronghao Zhang, Brett Schuhler, Autumn Brostek, Agustin Gonzalez-Vicente, Jeffrey L Garvin
BACKGROUND: A fructose high-salt (FHS) diet increases systolic blood pressure and Ang II (angiotensin II)-stimulated proximal tubule (PT) superoxide (O2 - ) production. These increases are prevented by scavenging O2 - or an Ang II type 1 receptor antagonist. SGLT4 (sodium glucose-linked cotransporters 4) and SGLT5 are implicated in PT fructose reabsorption, but their roles in fructose-induced hypertension are unclear. We hypothesized that PT fructose reabsorption by SGLT5 initiates a genetic program enhancing Ang II-stimulated oxidative stress in males and females, thereby causing fructose-induced salt-sensitive hypertension...
March 28, 2024: Hypertension
https://read.qxmd.com/read/38540233/classical-and-alternative-pathways-of-the-renin-angiotensin-aldosterone-system-in-regulating-blood-pressure-in-hypertension-and-obese-adolescents
#2
JOURNAL ARTICLE
Adrian Martyniak, Dorota Drożdż, Przemysław J Tomasik
Primary hypertension (PH) is the leading form of arterial hypertension (AH) in adolescents. Hypertension is most common in obese patients, where 20 to 40% of the population has elevated blood pressure. One of the most effective mechanisms for regulating blood pressure is the renin-angiotensin-aldosterone system (RAAS). The new approach to the RAAS talks about two opposing pathways between which a state of equilibrium develops. One of them is a classical pathway, which is responsible for increasing blood pressure and is represented mainly by the angiotensin II (Ang II) peptide and, to a lesser extent, by angiotensin IV (Ang IV)...
March 10, 2024: Biomedicines
https://read.qxmd.com/read/38537386/non-steroidal-anti-inflammatory-drugs-renin-angiotensin-system-blockade-or-diuretics-and-risk-of-acute-kidney-injury-a-case-crossover-study
#3
JOURNAL ARTICLE
Shao-En Weng, Wan-Tseng Hsu, Fei-Yuan Hsiao, Chii-Ming Lee
BACKGROUND: Aging-related physiological changes, such as decline in renal function, not only exacerbates pre-existing comorbidities but also escalate the susceptibility to adverse events. Previous studies have shown that non-steroidal anti-inflammatory drugs (NSAIDs) are associated with an increased risk of acute kidney injury (AKI), and the concomitant use of renin-angiotensin system blockade or diuretics may further potentiate the risk. However, studies evaluating the risk of AKI associated with NSAIDs (including routes, concomitant use of different NSAIDs, categories (traditional NSAIDs or COX-2 inhibitors), and cumulative doses of NSAIDs) are limited, particularly the risk of AKI associated with the dual or triple combination of NSAIDs with renin-angiotensin system blockade (RAS blockades) and/or diuretics...
March 26, 2024: Archives of Gerontology and Geriatrics
https://read.qxmd.com/read/38535093/cardiopulmonary-exercise-testing-in-heart-failure
#4
REVIEW
Michel Juarez, Cristian Castillo-Rodriguez, Dina Soliman, Gaspar Del Rio-Pertuz, Kenneth Nugent
Cardiopulmonary exercise testing (CPET) provides important information for the assessment and management of patients with heart failure. This testing measures the respiratory and cardiac responses to exercise and allows measurement of the oxygen uptake (V˙O2 ) max and the relationship between minute ventilation (V˙E) and carbon dioxide excretion (V˙CO2 ). These two parameters help classify patients into categories that help predict prognosis, and patients with a V˙O2 < 14 mL/kg/min and V˙E/V˙CO2 slope >35 have a poor prognosis...
February 20, 2024: Journal of Cardiovascular Development and Disease
https://read.qxmd.com/read/38532242/ace2-rescues-sepsis-associated-encephalopathy-by-reducing-inflammation-oxidative-stress-and-neuronal-apoptosis-via-the-nrf2-sestrin2-signaling-pathway
#5
JOURNAL ARTICLE
Ya Li, Tian-Tian Wan, Jia-Xin Li, Xue Xiao, Lei Liu, Hui-Hua Li, Shu-Bin Guo
Neuroinflammation and oxidative stress contribute to the progression of sepsis-associated encephalopathy (SAE). Angiotensin-converting enzyme 2 (ACE2) is considered to be a neuroprotective factor due to its anti-inflammatory and antioxidant properties. However, the role of ACE2 on myeloid cells in regulating SAE and the underlying mechanism warrants further exploration. SAE was induced in ACE2 transgenic (TG), knockout (KO), and bone marrow (BM) chimeric mice by cecal ligation and puncture (CLP). The expression levels of apoptosis-, oxidation- and neuroinflammation-associated mediators and morphological changes were monitored by quantitative real-time PCR analyses and histological examinations in the cortex of septic mice...
March 27, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38512760/investigation-of-the-relationship-of-nesfatin-1-adropin-levels-and-claudin-2-renalase-immunoreactivity-with-kidney-function-in-an-experimental-hypertension-model
#6
JOURNAL ARTICLE
Muhammed Ali Aydin, Nurettin Aydogdu, Ebru Tastekin, Nihayet Firat, Ozlem Yalcinkaya Yavuz
OBJECTIVE: Hypertension is one of the cardiovascular diseases that causes the most mortality, and 95% of the causes are unknown. The aim of the study was to examine the possible correlation of nesfatin-1 levels, adropin levels, claudin-2 immunoreactivity (claudin-2 expression in the renal proximal tubule), and renalase immunoreactivity (renalase expression in the renal proximal tubule) with arterial blood pressure, kidney function, and kidney damage. METHODS: Adult male Sprague Dawley rats were divided into control and hypertension groups (8 per group)...
March 2024: Puerto Rico Health Sciences Journal
https://read.qxmd.com/read/38511994/renin-levels-and-angiotensin-ii-responsiveness-in-vasopressor-dependent-hypotension
#7
JOURNAL ARTICLE
Emily J See, Anis Chaba, Sofia Spano, Akinori Maeda, Caroline Clapham, Louise M Burrell, Jasmine Liu, Monique Khasin, Grace Liskaser, Glenn Eastwood, Rinaldo Bellomo
OBJECTIVES: The relationship between renin levels, exposure to renin-angiotensin system (RAS) inhibitors, angiotensin II (ANGII) responsiveness, and outcome in patients with vasopressor-dependent vasodilatory hypotension is unknown. DESIGN: We conducted a single-center prospective observational study to explore whether recent RAS inhibitor exposure affected baseline renin levels, whether baseline renin levels predicted ANGII responsiveness, and whether renin levels at 24 hours were associated with clinical outcomes...
March 21, 2024: Critical Care Medicine
https://read.qxmd.com/read/38511617/impact-of-lactiplantibacillus-plantarum-and-casein-fortification-on-angiotensin-converting-enzyme-inhibitory-peptides-in-yogurt-identification-and-in-silico-analysis
#8
JOURNAL ARTICLE
Jiaxu Wang, Zhimin Wang, Mixia Zhang, Jiaxin Li, Cuisong Zhao, Chunli Ma, Dexing Ma
In this study, the effects of Lactiplantibacillus plantarum M11 ( Lb. plantarum M11) in conjunction with sodium caseinate on the characteristics and angiotensin converting enzyme (ACE) inhibitory activity of yogurt were investigated. ACE inhibitory peptides (ACEIPs) in yogurt were identified by nano-LC-MS/MS and potential ACEIPs were predicted by in silico and molecular docking methods. The results showed that the ACE-inhibitory activity of yogurt was significantly enhanced ( p < 0.05), while maintaining the quality characteristics of the yogurt...
March 21, 2024: Food & Function
https://read.qxmd.com/read/38510288/heart%C3%A2-failure-readmission-in-patients-with-st-segment-elevation-myocardial-infarction-and-active-cancer
#9
JOURNAL ARTICLE
Mohamed Dafaalla, Dmitry Abramov, Harriette G C Van Spall, Arjun K Ghosh, Chris P Gale, Sarah Zaman, Muhammad Rashid, Mamas A Mamas
BACKGROUND: Although numerous studies have examined readmission with heart failure (HF) after acute myocardial infarction (AMI), limited data are available on HF readmission in cancer patients post-AMI. OBJECTIVES: This study aimed to assess the rates and factors associated with HF readmission in cancer patients presenting with ST-segment elevation myocardial infarction (STEMI). METHODS: A nationally linked cohort of STEMI patients between January 2005 and March 2019 were obtained from the UK Myocardial Infarction National Audit Project registry and the UK national Hospital Episode Statistics Admitted Patient Care registry...
February 2024: JACC CardioOncology
https://read.qxmd.com/read/38509729/hbi-8000-improves-heart-failure-with-preserved-ejection-fraction-via-the-tgf-%C3%AE-1-mapk-signalling-pathway
#10
JOURNAL ARTICLE
Jing Tian, Wenjing Li, Lu Zeng, Yang Li, Jiamin Du, Ying Li, Bin Li, Guohai Su
Heart failure with preserved ejection fraction (HFpEF) accounts for approximately 50% of total heart failure patients and is characterized by peripheral circulation, cardiac remodelling and comorbidities (such as advanced age, obesity, hypertension and diabetes) with limited treatment options. Chidamide (HBI-8000) is a domestically produced benzamide-based histone deacetylase isoform-selective inhibitor used for the treatment of relapsed refractory peripheral T-cell lymphomas. Based on our in vivo studies, we propose that HBI-8000 exerts its therapeutic effects by inhibiting myocardial fibrosis and myocardial hypertrophy in HFpEF patients...
April 2024: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/38506079/indoxyl-sulphate-initiated-activation-of-cardiac-fibroblasts-is-modulated-by-aryl-hydrocarbon-receptor-and-nuclear-factor-erythroid-2-related-factor-2
#11
JOURNAL ARTICLE
Chiara Barisione, Daniela Verzola, Silvano Garibaldi, Paola Altieri, Anna Lisa Furfaro, Mariapaola Nitti, Giovanni Pratesi, Domenico Palombo, Pietro Ameri
In the last decade, extensive attention has been paid to the uremic toxin indoxyl sulphate (IS) as an inducer of cardiac fibroblast (cFib) activation and cardiac fibrosis in chronic kidney disease. At cellular level, IS engages aryl hydrocarbon receptor (AhR) and regulates many biological functions. We analysed how AhR inhibition by CH-223191 (CH) and overexpression of non-functional (dominant negative, DN) nuclear factor-erythroid-2-related factor 2 (NRF2), a transcription factor recruited by AhR, modulate the response of neonatal mouse (nm) cFib to IS...
April 2024: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/38503013/irbesartan-ameliorates-diabetic-nephropathy-by-activating-the-nrf2-keap1-pathway-and-suppressing-nlrp3-inflammasomes-in-vivo-and-in-vitro
#12
JOURNAL ARTICLE
Yuan Li, Weihong Long, Haifeng Zhang, Meng Zhao, Menghan Gao, Weiying Guo, Lu Yu
OBJECTIVES: Diabetic nephropathy (DN) is characterized by albuminuria and renal dysfunction caused by diabetes. At present there is no specific treatment for DN. Irbesartan (IRB) is an angiotensin receptor inhibitor indicated for the treatment of hypertension and DN. However, the underlying molecular mechanisms of IRB on DN remains obscure. METHODS: RAW264.7 macrophages were incubated in RPMI-1640, cell viability was evaluated by CCK-8 assays, transcriptional level of proinflammatory cytokines and was measured by ELISA and qPCR, NLRP3 inflammasome and Nrf2/Keap1 related proteins were measured by Western blotting and immunohistochemistry...
March 18, 2024: International Immunopharmacology
https://read.qxmd.com/read/38500680/ionizable-lipid-nanoparticle-mediated-trail-mrna-delivery-in-the-tumor-microenvironment-to-inhibit-colon-cancer-progression
#13
JOURNAL ARTICLE
Walison Nunes da Silva, Pedro Augusto Carvalho Costa, Sérgio Ricardo Aluotto Scalzo Júnior, Heloísa A S Ferreira, Pedro Henrique Dias Moura Prazeres, Caroline Leonel Vasconcelos Campos, Marco Túllio Rodrigues Alves, Natália Jordana Alves da Silva, Ana Luiza de Castro Santos, Lays Cordeiro Guimarães, Maria Eduarda Chen Ferris, Ajay Thatte, Alex Hamilton, Kelly Alves Bicalho, Anderson Oliveira Lobo, Helton da Costa Santiago, Lucíola da Silva Barcelos, Maria Marta Figueiredo, Mauro Martins Teixeira, Vivian Vasconcelos Costa, Michael J Mitchell, Frédéric Frézard, Pedro Pires Goulart Guimaraes
INTRODUCTION: Immunotherapy has revolutionized cancer treatment by harnessing the immune system to enhance antitumor responses while minimizing off-target effects. Among the promising cancer-specific therapies, tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has attracted significant attention. METHODS: Here, we developed an ionizable lipid nanoparticle (LNP) platform to deliver TRAIL mRNA (LNP-TRAIL) directly to the tumor microenvironment (TME) to induce tumor cell death...
2024: International Journal of Nanomedicine
https://read.qxmd.com/read/38498600/angiotensin-1-7-treatment-early-in-life-prevents-cardiac-hypertrophy-in-adult-hypertensive-rats
#14
JOURNAL ARTICLE
Carolina Nobre Ribeiro Pontes, Amanda de Sá Martins de Bessa, Larissa Matuda Macedo, Marcos Divino Ferreira-Junior, Keilah Valéria Naves Cavalcante, Hericles Mesquita Campos, Vanessa Rafaela Milhomem Cruz-Leite, Ângela Ribeiro Neves, Rodrigo Mello Gomes, Paulo César Ghedini, Manoel Francisco Biancardi, Elizabeth Pereira Mendes, Clayton Luiz Borges, Gustavo Rodrigues Pedrino, Carlos Henrique Castro
Angiotensin (Ang)-(1-7) is a cardioprotective peptide of the renin-angiotensin system. Pre-puberty has been considered as a later susceptible window of development and stressful factors in this life phase can induce chronic diseases in adulthood. We aimed to investigate whether the treatment with Ang-(1-7) during the pre-puberty could attenuate the development of hypertension and cardiac injury in adult spontaneously hypertensive rats (SHR). SHR were treated with Ang-(1-7) (24 μg/Kg/h) from 4 to 7 weeks of age...
March 12, 2024: Journal of Cardiovascular Pharmacology
https://read.qxmd.com/read/38498345/candesartan-upregulates-angiotensin-converting-enzyme-2-in-kidneys-of-male-animals-by-decreased-ubiquitination
#15
JOURNAL ARTICLE
Ping Wang, Zhiyun Ren, Weiwan Wang, Mingda Liu, Yutao Jia, Mingzhuo Zhang, Ying Xue, Chenyang Zhang, Jianteng Xu, Cheng Wang, Xiaoyan Wang
Candesartan is a common angiotensin-II receptor-1 blocker used for patients with cardiovascular and renal diseases. Angiotensin-converting enzyme 2 (ACE2) is a negative regulator of blood pressure (BP), and also a major receptor for coronaviruses. To determine whether and how candesartan upregulates ACE2, we examined BP and ACE2 in multi-organs from male and female C57BL/6J mice treated with candesartan (1 mg/kg, i.p.) for 7 days. Relative to the vehicle, candesartan lowered BP more in males than females; ACE2 protein abundances were increased in kidneys, not lungs, hearts, aorta, liver, spleen, brain, or serum, only from males...
March 31, 2024: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/38491214/early-detection-of-anthracycline-induced-cardiotoxicity-using-68-%C3%A2-ga-ga-fapi-04-imaging
#16
JOURNAL ARTICLE
Zhuxin Wei, Hongchuang Xu, Bixi Chen, Jiaxin Wang, Xing Yang, Min-Fu Yang, Shihua Zhao
PURPOSE: Anthracycline-induced cardiotoxicity (AIC), whose major manifestation is diffuse myocardial fibrosis, is an important clinical problem in cancer therapy. Therefore, early identification and treatment are clinically important. This study aims to explore the feasibility of using 68  Ga-labelled fibroblast activation protein (FAP) inhibitor ([68  Ga]Ga-FAPI) positron emission tomography/computed tomography (PET/CT) for the early identification of the fibrotic process and guidance of antifibrosis therapy in AIC...
March 16, 2024: European Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/38489957/quantification-of-endogenous-angiotensin-1-10-1-9-1-8-1-7-and-1-5-in-human-plasma-using-micro-uhplc-ms-ms-outlining-the-importance-of-the-pre-analytics-for-reliable-results
#17
JOURNAL ARTICLE
Jonathan Maurer, Anke de Groot, Léon Martin, Eric Grouzmann, Grégoire Wuerzner, Philippe J Eugster
Angiotensin peptides (ANGs) play a central role in the renin-angiotensin-aldosterone system, rendering them interesting biomarkers associated with hypertension. Precise quantification of circulating ANGs holds the potential to assess the activity of angiotensin-converting enzyme (ACE), a key protease targeted by widely prescribed drugs, namely ACE inhibitors. This ability could pave the way for personalised medicine, offering insights into the prescription of inhibitors targeting either the proteases or the receptors within the system...
March 9, 2024: Journal of Pharmaceutical and Biomedical Analysis
https://read.qxmd.com/read/38488216/unraveling-the-crosstalk-between-renin-angiotensin-system-receptors
#18
REVIEW
Mariela M Gironacci, Ezequiel Bruna-Haupt
The renin-angiotensin system (RAS) plays a key role in blood pressure regulation. The RAS is a complex interconnected system composed of two axes with opposite effects. The pressor arm, represented by angiotensin (Ang) II and the AT1 receptor (AT1 R), mediates the vasoconstrictor, proliferative, hypertensive, oxidative, and pro-inflammatory effects of the RAS, while the depressor/protective arm, represented by Ang-(1-7), its Mas receptor (MasR) and the AT2 receptor (AT2 R), opposes the actions elicited by the pressor arm...
March 15, 2024: Acta Physiologica
https://read.qxmd.com/read/38485776/donepezil-attenuates-progression-of-cardiovascular-remodeling-and-improves-prognosis-in-spontaneously-hypertensive-rats-with-chronic-myocardial-infarction
#19
JOURNAL ARTICLE
Meihua Li, Can Zheng, Toru Kawada, Kazunori Uemura, Shohei Yokota, Hiroki Matsushita, Keita Saku
The acetylcholinesterase inhibitor donepezil restores autonomic balance, reduces inflammation, and improves long-term survival in rats with chronic heart failure (CHF) following myocardial infarction (MI). As arterial hypertension is associated with a significant risk of cardiovascular death, we investigated the effectiveness of donepezil in treating CHF in spontaneously hypertensive rats (SHR). CHF was induced in SHR by inducing permanent MI. After 2 weeks, the surviving SHR were randomly assigned to sham-operated (SO), untreated (UT), or oral donepezil-treated (DT, 5 mg/kg/day) groups, and various vitals and parameters were monitored...
March 14, 2024: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://read.qxmd.com/read/38481714/eligibility-and-potential-benefit-of-transcatheter-edge-to-edge-repair-in-a-contemporary-cohort-with-heart-failure-evidence-from-a-large-integrated-health-care-delivery-system
#20
JOURNAL ARTICLE
Andrew P Ambrosy, Jingrong Yang, Andrew S Tai, Sadia J Dimbil, Elisha A Garcia, Sue Hee Sung, Ankeet S Bhatt, Matthew D Solomon, Ivy A Ku, Jacob M Mishell, Edward J McNulty, Jonathan G Zaroff, Andrew N Rassi, Jeremy Kong, Alan S Go
BACKGROUND: The eligibility and potential benefit of transcatheter edge-to-edge repair (TEER) in addition to guideline-directed medical therapy to treat moderate-severe or severe secondary mitral regurgitation (MR) has not been reported in a contemporary heart failure (HF) population. METHODS: Eligibility for TEER based on Food and Drug Administration (FDA) labeling: (1) HF symptoms, (2) moderate-severe or severe MR, (3) left ventricular ejection fraction (LVEF) 20% to 50%, (4) left ventricular end-systolic dimension 7...
March 2024: Structural heart: the journal of the Heart Team
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