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Pharmaceutical technology, formulation of herbal medicine.

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https://www.readbyqxmd.com/read/26760986/chinese-herbal-medicines-for-unexplained-recurrent-miscarriage
#1
REVIEW
Lu Li, Lixia Dou, Ping Chung Leung, Tony Kwok Hung Chung, Chi Chiu Wang
BACKGROUND: Recurrent miscarriage affects 1% to 3% of women of reproductive age and mostly occurs before the 10th week of gestation (and around the same gestational week in subsequent miscarriages). Although most pregnant women may not recognise a miscarriage until uterine bleeding and cramping occur, a repeat miscarriage after one or more pregnancy loss and the chance of having a successful pregnancy varies. To date, there is no universally accepted treatment for unexplained recurrent miscarriage...
2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/23488906/ayurvedic-drug-discovery
#2
Premalatha Balachandran, Rajgopal Govindarajan
Ayurveda is a major traditional system of Indian medicine that is still being successfully used in many countries. Recapitulation and adaptation of the older science to modern drug discovery processes can bring renewed interest to the pharmaceutical world and offer unique therapeutic solutions for a wide range of human disorders. Eventhough time-tested evidences vouch immense therapeutic benefits for ayurvedic herbs and formulations, several important issues are required to be resolved for successful implementation of ayurvedic principles to present drug discovery methodologies...
December 2007: Expert Opinion on Drug Discovery
https://www.readbyqxmd.com/read/23270249/-design-technology-of-traditional-chinese-medicine-component-and-formulation
#3
Dan-hong Yu, Dan Liu, Zheng-hai Zhang, E Sun, Xiao-bin Jia
The development of traditional Chinese medicine lies in its significant clinical efficacy which is closely related to the bioavailability of drugs. The nature of the material foundation of compounds of traditional Chinese medicine is reflected in multi-component. As for the nature of components themselves, the level of their bioavailability depends on the biopharmaceutical properties, namely solubility and permeability, to a great extent. Therefore, under the guidance of the theory of traditional Chinese medicine and in the combination with modern preparation techniques, this essay reveals key techniques capable of improving the biopharmaceutical properties of components, in the hope of enhancing the clinical efficacy of components of traditional Chinese medicine...
October 2012: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/23010007/formulation-and-evaluation-of-herbal-anti-acne-moisturizer
#4
Arun Rasheed, Shaik Neelufar Shama, Jyothi Mulanjananiyil Joy, Bobbu Sravya Reddy, Chirra Roja
The moisture content present in human skin makes it look young and the use of moisturizer results in fastening the moisture with a surface film of oil. Acne vulgaris is one of the most commonly seen diseases among the youth. The present study is focused on the use of herbs as moisturizer for acne treatment. The anti-acne moisturizer was formulated from herbal crude extracts and investigated the physico-chemical parameters as well as antibacterial activity of the formulation. The study revealed that ethanol extract of Andrographis paniculata, Glycyrrhiza glabra, Ocimum sanctum, Azadiracta indica and Green tea possessed the potential for inhibiting acne...
October 2012: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/22960627/the-filling-of-powdered-herbs-into-two-piece-hard-capsules-using-hydrogenated-cotton-seed-oil-as-lubricant
#5
Joanna Aling, Fridrun Podczeck
The aim of this work was to investigate the plug formation and filling properties of powdered herbal leaves using hydrogenated cotton seed oil as an alternative lubricant. In a first step, unlubricated and lubricated herbal powders were studied on a small scale using a plug simulator, and low-force compression physics and parameterization techniques were used to narrow down the range in which the optimum amount of lubricant required would be found. In a second step these results were complemented with investigations into the flow properties of the powders based on packing (tapping) experiments to establish the final optimum lubricant concentration...
November 20, 2012: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/21823466/-study-on-optimization-of-formulation-of-danggui-liuhuang-effervescent-granules
#6
Ping Zheng, Li-Juan Meng, Guo-Ping Sun, Wen-Zhong Wang
OBJECTIVE: To optimize the formulation of Danggui Liuhuang effervescent granules. METHODS: By means of quadratic regression rotation-orthogonal combination design, the effect of the proper proportion between citric acid and sodium bicarbonate, as well as the proper quantity of polyethylene glycol 6000 and sodium cyclamate on the dissolubility and pH of effervescent granules was studied. RESULTS: The best formulation was as follows: citric acid: sodium bicarbonate = 0...
March 2011: Zhong Yao Cai, Zhongyaocai, Journal of Chinese Medicinal Materials
https://www.readbyqxmd.com/read/21664786/a-support-vector-machine-based-pharmacodynamic-prediction-model-for-searching-active-fraction-and-ingredients-of-herbal-medicine-naodesheng-prescription-as-an-example
#7
COMPARATIVE STUDY
Chao Chen, Shu-xian Li, Shu-mei Wang, Sheng-wang Liang
The complex chemical composition of herbal medicine leads to the lack of appropriate method for identifying active compounds and optimizing the formulation of herbal medicine. One of the most commonly used method is bioassay-guided fractionation. However, if the herbal medicine was divided into many fractions, it would cost much money and time in carrying out such a full bioassay. So, can we just perform the bioassay of a few fractions, and then develop a method to predict the bioactivities of other fractions? This study is designed to try to answer the question...
September 10, 2011: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/21664785/a-strategy-for-the-detection-of-quality-fluctuation-of-a-chinese-herbal-injection-based-on-chemical-fingerprinting-combined-with-biological-fingerprinting
#8
Yongshen Ren, Ping Zhang, Dan Yan, Jiabo Wang, Xiaoxi Du, Xiaohe Xiao
Herbal injections are powerful preparations of traditional Chinese medicines. However, the quality control (QC) of these formulations is difficult to establish. Recently, chemical fingerprinting (CF) has been recommended as a potential strategy for the QC of herbal injections. However, some constituents cannot be detected by chromatographic methods. To establish a comprehensive QC process, biological fingerprinting (BF) was combined with CF to detect the fluctuation in quality of a herbal injection from chemical and biological aspects...
September 10, 2011: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/21411014/natural-products-as-starting-points-for-future-anti-malarial-therapies-going-back-to-our-roots
#9
REVIEW
Timothy N C Wells
BACKGROUND: The discovery and development of new anti-malarials are at a crossroads. Fixed dose artemisinin combination therapy is now being used to treat a hundred million children each year, with a cost as low as 30 cents per child, with cure rates of over 95%. However, as with all anti-infective strategies, this triumph brings with it the seeds of its own downfall, the emergence of resistance. It takes ten years to develop a new medicine. New classes of medicines to combat malaria, as a result of infection by Plasmodium falciparum and Plasmodium vivax are urgently needed...
2011: Malaria Journal
https://www.readbyqxmd.com/read/21094011/metabolic-profiling-of-guanxin-ii-prescription-based-on-metabolic-fingerprinting-and-chemical-analysis
#10
COMPARATIVE STUDY
Xue Qiao, Jian Han, Man Xu, Zi-chuan Zhang, Min Ye, Guan Ye, De-an Guo
A sensitive LC/MS method was established to investigate the in vivo metabolism of GuanXin II prescription, a five-component Chinese herbal medicine formulation. Rat plasma, bile, urine, and feces were collected and analyzed following oral administration of the water decoction. A total of 50 compounds were identified, including 17 prototypes and 33 metabolites underwent methylation, oxidation, hydrolysis, sulfate conjugation, glucuronide conjugation, and glutathion conjugation. In addition, the component herb of the formulation from which the metabolites were derived was also identified...
March 25, 2011: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/20685501/effects-of-the-pharmaceutical-technologic-aspects-of-oral-pediatric-drugs-on-patient-related-outcomes-a-systematic-literature-review
#11
REVIEW
Diana A van Riet-Nales, Alfred F A M Schobben, Toine C G Egberts, Carin M A Rademaker
BACKGROUND: In view of the high rates of off-label and unlicensed prescribing of drugs in children, the US Food and Drug Administration and the European Union have implemented legislative regulations for the pharmaceutical industry to increase the number of drugs with approved pediatric labeling. However, the extent to which the effects of pharmaceutical technologic aspects of pediatric oral drugs (eg, taste, route and frequency of administration, user instructions) on patient-related outcomes (eg, efficacy, tolerability, preference, adherence) can be based on clinical evidence from the available literature is unknown...
May 2010: Clinical Therapeutics
https://www.readbyqxmd.com/read/20432912/-research-on-formulation-process-of-yisheng-capsule
#12
Jian Lei, Mao Xing, Xue-lian Hu, En-juan Zhang, Yi Peng
OBJECTIVE: To choose the best supplementary material and formulation process of Yisheng capsules. METHODS: The angle of repose, hygroscopicity and critical relative humidity were used as the indices to choose the formulation process of Yisheng capsules. RESULTS: The best technique conditions were as follows: the extract powder and microcrystalline cellulose were mixed in proportion of 2:1, the 95% alcohol was used as the wetting agent. CONCLUSION: The formulation process is rational and practicable...
December 2009: Zhong Yao Cai, Zhongyaocai, Journal of Chinese Medicinal Materials
https://www.readbyqxmd.com/read/20353000/-optimized-preparation-of-dry-powder-inhalation-of-rehmannia-glutinosa-oligosaccharides-by-central-composite-design-and-response-surface-method
#13
Liqin Ding, Li Liu, Desheng Xu
OBJECTIVE: To optimize the formulation of dry powder inhalation of Rehmannia glutinosa oligosaccharides (RGOS-DPI) extracted from traditional Chinese medicinal herbs. METHOD: RGOS-DPI was prepared by spray drying technique. Dependent variables such as yield, moisture absorption rate, emptying rate and mean diameter of micropowder were transformed into desirabilities mathematically by Hassan's method. Overall desirability was calculated from the geometric mean of the four desirabilities of each formulation...
December 2009: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/20218300/-study-on-the-optimal-extraction-process-of-chaihushugan-powder
#14
Chun-yan Wang, Wan-ming Zhang, Dan-shen Zhang, Fang An, Jia-ming Tian
OBJECTIVE: To study the optimal extraction process of chaihushugan powder by orthogonal design. METHODS: RP-HPLC method was developed for the determination of saikosaponin a, ferulic acid, hesperidin and paeoniflorin in chaihushugan powder. The contents of the components and the extraction yield were selected as assessment indices. Four factors were study by L9 (3(4)), including the alcohol concentration, amount of alcohol, duration of extraction and times of extraction...
November 2009: Zhong Yao Cai, Zhongyaocai, Journal of Chinese Medicinal Materials
https://www.readbyqxmd.com/read/20034225/-study-on-the-preparation-of-sustained-release-pellets-containing-active-components-from-gastrodia-elata-by-fluid-bed-coating
#15
Yan-long Hong, Xiao Lin, De-sheng Xu, Yi Feng, Jun-song Li, Ya-jun Zhang
OBJECTIVE: To study the formulation of sustained-release pellets containing active components from Gastrodia elata by coating in the fluid-bed. METHODS: The sustained-release pellets were prepared with Eudragit RS 100. The formulation was optimized by the direct comparison. Then their properties were evaluated. RESULTS: The pellets presented the perfect sphericity and narrow diameter distribution and the curve of their cumulative drug release was in accord with Higuchi equation...
September 2009: Zhong Yao Cai, Zhongyaocai, Journal of Chinese Medicinal Materials
https://www.readbyqxmd.com/read/19505192/status-of-novel-drug-delivery-technology-for-phytotherapeutics
#16
REVIEW
S Mohamed Musthaba, Sanjula Baboota, Sayeed Ahmed, Alka Ahuja, Javed Ali
Herbal medicines have been widely used all over the world since ancient times and have been recognized by physicians and patients for their better therapeutic value as they have fewer adverse effects as compared with modern medicines. However, phytotherapeutics needs a scientific approach to deliver the components in a sustained manner to increase patient compliance and avoid repeated administration. This can be achieved by designing novel drug delivery systems for herbal constituents. Novel drug delivery systems not only reduce the repeated administration to overcome non-compliance, but also help to increase the therapeutic value by reducing toxicity and increasing the bioavailability, and so on...
June 2009: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/19230415/-preparation-of-zhongjiefeng-dispersible-tablets
#17
Zhen-Feng Wu, Wei He, Yong Li
OBJECTIVE: To prepare Zhongjiefeng dispersible tablets. METHODS: The formulation of Zhongjiefeng dispersible tablets were optimized as index of disintegration time by orthogonal design test. RESULTS: The optimized Zhongjiefeng dispersible tablets, which were prepared by selecting 16% PVPP and 3% L-HPC as disintegrants, 40% MCC as filler, can disintegrate in 3 mins. CONCLUSIONS: The above formulation is reasonable and the disintegration time is suitable, so it can provide theoretic support for industrialization...
October 2008: Zhong Yao Cai, Zhongyaocai, Journal of Chinese Medicinal Materials
https://www.readbyqxmd.com/read/18998579/-preparation-of-self-microemulsifying-soft-capsule-and-investigation-of-dissolution-for-duyiwei
#18
Sheng-Miao Cui, Xue-Mei Shen
OBJECTIVE: To prepare the self-microemulsifying soft capsule (SMESC) of Duyiwei and investigate its dissolution property. METHODS: Through solubility experiment, self-microemulsification in vitro, drawing phase diagram and investigating the stability of solution, the optimum formulation was determined for Duyiwei. The dissolution of SMESC was measured, taking the commercial capsule as reference. RESULTS: In the optimum formulation, Labrasol, Transcutol P and ethyl oleate were screened as emulsifier, co-emulsifier and oil phase, respectively...
June 2008: Zhong Yao Cai, Zhongyaocai, Journal of Chinese Medicinal Materials
https://www.readbyqxmd.com/read/18826153/-optimization-for-formulation-matrix-proportion-of-xiangyu-cataplasm-by-uniform-design
#19
Ke Xu, Pei-Hu Xu, Xue-Qiong Zhang, Yuan Gao, Liang Zhang
OBJECTIVE: To optimize the matrix formulation of cataplasm used to cure infantile diarrhea. METHODS: The optimum proportion of matrix for the preparation technology process of cataplasm was selected by uniform design and SPSS regression analysis. A check-up for adhibition , peeling strength, nonflowing, content of cream was founded. RESULTS: The best matrix's prescription gelatin: CMC-Na: PANA: kaolin: aluminum trichloride: citric acid: PVP K-30: PEG400: trimethylene glycol: tween-80 was 0...
May 2008: Zhong Yao Cai, Zhongyaocai, Journal of Chinese Medicinal Materials
https://www.readbyqxmd.com/read/18619254/-studies-on-the-decoction-isometric-from-zingiberaceae-materials-for-medicine
#20
Dan-Na Xu, Xue-Tao Li, Yi Cheng
OBJECTIVE: To study the decoction isometric from Zingiberaceae materials for medicine. METHODS: We decocted the herb under the simulation decoction condition, contained the volatile oil which dissipated from the decoction and the concentration process, dried the broth, and computed the received rate. RESULTS: We Obtained the loss percentage of the volatile oil for various raw matrials for medicine in the decoction process, the amount of volatile oil which was contained in the physic liquor, and the decoction isometric dosage...
March 2008: Zhong Yao Cai, Zhongyaocai, Journal of Chinese Medicinal Materials
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