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Robotized radiosurgery

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https://www.readbyqxmd.com/read/29874299/repeated-in-field-radiosurgery-for-locally-recurrent-brain-metastases-feasibility-results-and-survival-in-a-heavily-treated-patient-cohort
#1
Panagiotis Balermpas, Susanne Stera, Jens Müller von der Grün, Britta Loutfi-Krauss, Marie-Thérèse Forster, Marlies Wagner, Christian Keller, Claus Rödel, Volker Seifert, Oliver Blanck, Robert Wolff
PURPOSE: Stereotactic radiosurgery (SRS) is an established primary treatment for newly diagnosed brain metastases with high local control rates. However, data about local re-irradiation in case of local failure after SRS (re-SRS) are rare. We evaluated the feasibility, efficacy and patient selection characteristics in treating locally recurrent metastases with a second course of SRS. METHODS: We retrospectively evaluated patients with brain metastases treated with re-SRS for local tumor progression between 2011 and 2017...
2018: PloS One
https://www.readbyqxmd.com/read/29858498/evaluation-of-the-accuracy-of-the-cyberknife-synchrony-%C3%A2-respiratory-tracking-system-using-a-plastic-scintillator
#2
Yuichi Akino, Iori Sumida, Hiroya Shiomi, Naokazu Higashinaka, Yoshiichi Murashima, Miori Hayashida, Nobuhisa Mabuchi, Kazuhiko Ogawa
PURPOSE: The Synchrony™ Respiratory Tracking System of the CyberKnife® Robotic Radiosurgery System (Accuray, Inc., Sunnyvale CA) enables real-time tracking of moving targets such as lung and liver tumors during radiotherapy. Although film measurements have been used for quality assurance of the tracking system, they cannot evaluate the temporal tracking accuracy. We have developed a verification system using a plastic scintillator that can evaluate the temporal accuracy of the CyberKnife Synchrony...
June 1, 2018: Medical Physics
https://www.readbyqxmd.com/read/29846895/clinical-outcomes-of-perioptic-tumors-treated-with-hypofractionated-stereotactic-radiotherapy-using-cyberknife%C3%A2-stereotactic-radiosurgery
#3
Putipun Puataweepong, Mantana Dhanachai, Ake Hansasuta, Somjai Dangprasert, Chomporn Sitathanee, Rawee Ruangkanchanasetr, Pornpan Yongvithisatid
INTRODUCTION: Stereotactic radiation technique is widely reported as an effective treatment for various types of benign intracranial tumors. However, single fraction radiosurgery (SRS) is not recommended for tumors located close to the optic apparatus due to the restricted radiation tolerance dose of the optic pathway. Recent advances in radiotherapy include advanced frameless radiosurgery using hypofractionated stereotactic radiotherapy (HSRT), and this has become an attractive treatment option for perioptic tumors within 2-3 mm of the optic pathway...
May 30, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29802435/treatment-planning-for-spinal-radiosurgery-a-competitive-multiplatform-benchmark-challenge
#4
Christos Moustakis, Mark K H Chan, Jinkoo Kim, Joakim Nilsson, Alanah Bergman, Tewfik J Bichay, Isabel Palazon Cano, Savino Cilla, Francesco Deodato, Raffaela Doro, Jürgen Dunst, Hans Theodor Eich, Pierre Fau, Ming Fong, Uwe Haverkamp, Simon Heinze, Guido Hildebrandt, Detlef Imhoff, Erik de Klerck, Janett Köhn, Ulrike Lambrecht, Britta Loutfi-Krauss, Fatemeh Ebrahimi, Laura Masi, Alan H Mayville, Ante Mestrovic, Maaike Milder, Alessio G Morganti, Dirk Rades, Ulla Ramm, Claus Rödel, Frank-Andre Siebert, Wilhelm den Toom, Lei Wang, Stefan Wurster, Achim Schweikard, Scott G Soltys, Samuel Ryu, Oliver Blanck
PURPOSE: To investigate the quality of treatment plans of spinal radiosurgery derived from different planning and delivery systems. The comparisons include robotic delivery and intensity modulated arc therapy (IMAT) approaches. Multiple centers with equal systems were used to reduce a bias based on individual's planning abilities. The study used a series of three complex spine lesions to maximize the difference in plan quality among the various approaches. METHODS: Internationally recognized experts in the field of treatment planning and spinal radiosurgery from 12 centers with various treatment planning systems participated...
May 25, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29749569/postoperative-hypofractionated-stereotactic-brain-radiation-hsrt-for-resected-brain-metastases-improved-local-control-with-higher-bed-10
#5
Aryavarta M S Kumar, Jonathan Miller, Seth A Hoffer, David B Mansur, Michael Coffey, Simon S Lo, Andrew E Sloan, Mitchell Machtay
INTRODUCTION: HSRT directed to large surgical beds in patients with resected brain metastases improves local control while sparing patients the toxicity associated with whole brain radiation. We review our institutional series to determine factors predictive of local failure. METHODS: In a total of 39 consecutive patients with brain metastases treated from August 2011 to August 2016, 43 surgical beds were treated with HSRT in three or five fractions. All treatments were completed on a robotic radiosurgery platform using the 6D Skull tracking system...
May 10, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29656632/long-term-survival-in-patients-treated-with-a-robotic-radiosurgical-device-for-liver-metastases
#6
Sebastian Stintzing, Jobst von Einem, Christoph Fueweger, Alfred Haidenberger, Michael Fedorov, Alexander Muavcevic
Purpose: The treatment of liver metastases with local procedures is a fast progressing field. For the most, long-term survival data is missing raising questions with regard to the efficacy of such modalities when compared to surgical resection. Radiosurgery using the CyberKnife device enables the treatment of liver lesions with a single-session approach. Here we present long-term survival data to explore the curative potential of this strategy. Materials and Methods: Patients with oligo-metastatic disease limited to the liver have been treated with single-session or hypo-fractioned radiosurgery in curative intent and prospectively followed until death...
April 16, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29621319/dosimetric-impact-of-intra-fraction-prostate-motion-under-a-tumour-tracking-system-in-hypofractionated-robotic-radiosurgery
#7
Yuhei Koike, Iori Sumida, Hirokazu Mizuno, Hiroya Shiomi, Keita Kurosu, Seiichi Ota, Yasuo Yoshioka, Osamu Suzuki, Keisuke Tamari, Kazuhiko Ogawa
For CyberKnife-mediated prostate cancer treatment, a tumour-tracking approach is applied to correct the target location by acquiring X-ray images of implanted fiducial markers intermittently. This study investigated the dosimetric impact of intra-fraction prostate motion during CyberKnife treatment. We retrospectively analyzed 16 patients treated using the CyberKnife (35 Gy delivered in five fractions). Using log files of recorded prostate motion, the intra-fraction prostate motion was simulated. We defined the worst-case intra-fraction prostate motion as the difference between pre- and post-deviation on log files and shifted structure sets according to the corresponding offsets for each beam...
2018: PloS One
https://www.readbyqxmd.com/read/29605528/cyberknife-stereotactic-radiosurgery-and-radiation-therapy-treatment-planning-system
#8
REVIEW
Chuxiong Ding, Cheng B Saw, Robert D Timmerman
CyberKnife is an image-guided stereotactical dose delivery system designed for both focal irradiation and radiation therapy (SRT). Focal irradiation refers the use of many small beams to deliver highly focus dose to a small target region in a few fractions. The system consists of a 6-MV linac mounted to a robotic arm, coupled with a digital x-ray imaging system. The radiation dose is delivered using many beams oriented at a number of defined or nodal positions around the patients. The CyberKnife can be used for both intracranial and extracranial treaments unlike the Gamma Knife which is limited to intracranial cases...
July 2018: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/29554321/robotic-radiosurgery-for-brain-metastases-diagnosed-with-either-space-or-mprage-sequence-cyber-space-a-single-center-prospective-randomized-trial
#9
Rami A El Shafie, Angela Paul, Denise Bernhardt, Kristin Lang, Thomas Welzel, Tanja Sprave, Adriane Hommertgen, Johannes Krisam, Daniela Schmitt, Sebastian Klüter, Kai Schubert, Christina Klose, Meinhard Kieser, Jürgen Debus, Stefan Rieken
BACKGROUND: Stereotactic radiosurgery (SRS) of brain metastases (BM) is recommended in oligometastatic scenarios as a less toxic treatment alternative to whole-brain radiotherapy. Recent findings support SRS for patients with multiple (>3) BM. Furthermore, advances in MR imaging have facilitated the detection of very small BM, as advances in SRS technology have facilitated the highly conformal and simultaneous treatment of multiple target lesions. OBJECTIVE: To compare efficacy and toxicity of repeated frameless robotic SRS of up to 10 simultaneous BM through a single-center prospective randomized trial...
March 15, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29552780/patient-specific-quality-assurance-for-intracranial-cases-in-robotic-radiosurgery-system
#10
Canan Koksal, Ugur Akbas, Nazmiye Donmez Kesen, Murat Okutan, Hatice Bilge, Gonul Kemikler
PURPOSE: The purpose of this study was to perform pretreatment patient-specific quality assurance (QA) for intracranial irradiation using CyberKnife with an ion chamber. METHODS: Twenty-five intracranial plans created using the ray-tracing algorithm were used for this study. Computed tomography (CT) images of the water-equivalent RW3 slab phantom with PinPoint ionization chamber were acquired with 1-mm slice thickness and transferred to the MultiPlan treatment planning system (TPS)...
January 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29544504/in-silico-assessment-of-the-dosimetric-quality-of-a-novel-automated-radiation-treatment-planning-strategy-for-linac-based-radiosurgery-of-multiple-brain-metastases-and-a-comparison-with-robotic-methods
#11
Krzysztof Slosarek, Barbara Bekman, Jacek Wendykier, Aleksandra Grządziel, Antonella Fogliata, Luca Cozzi
BACKGROUND: To appraise the dosimetric features and the quality of the treatment plan for radiosurgery of multiple brain metastases optimized with a novel automated engine and to compare with plans optimized for robotic-based delivery. METHODS: A set of 15 patients with multiple brain metastases was selected for this in silico study. The technique under investigation is the recently introduced HyperArc. For all patients, three treatment plans were computed and compared: i: a HyperArc; ii: a standard VMAT; iii) a CyberKnife...
March 15, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29480166/methodology-to-reduce-6d-patient-positional-shifts-into-a-3d-linear-shift-and-its-verification-in-frameless-stereotactic-radiotherapy
#12
Biplab Sarkar, Jyotirmoy Ray, Tharmarnadar Ganesh, Arjunan Manikandan, Anusheel Munshi, Sasikumar Rathinamuthu, Harpreet Kaur, Satheeshkumar Anbazhagan, Upendra K Giri, Soumya Roy, Kanan Jassal, Bidhu Kalyan Mohanti
The aim of this article is to derive and verify a mathematical formulation for the reduction of the six-dimensional (6D) positional inaccuracies of patients (lateral, longitudinal, vertical, pitch, roll and yaw) to three-dimensional (3D) linear shifts. The formulation was mathematically and experimentally tested and verified for 169 stereotactic radiotherapy patients. The mathematical verification involves the comparison of any (one) of the calculated rotational coordinates with the corresponding value from the 6D shifts obtained by cone beam computed tomography (CBCT)...
March 22, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29429125/cyberknife-robotic-radiosurgery-in-the-multimodal-management-of-acromegaly-patients-with-invasive-macroadenoma-a-single-center-s-experience
#13
Elisa Sala, Justin M Moore, Alvaro Amorin, Hector Martinez, Aprotim C Bhowmik, Layton Lamsam, Steven Chang, Scott G Soltys, Laurence Katznelson, Griffith R Harsh
Surgery is the primary treatment for acromegaly. However, surgery may not be curative of some tumors, particularly invasive macroadenomas. Adjuvant radiation, specifically robotic stereotactic radiosurgery (rSRS), may improve the endocrine outcome. We retrospectively reviewed hormonal and radiological data of 22 acromegalic patients with invasive macroadenomas treated with rSRS at Stanford University Medical Center between 2000 and 2016. Prior to treatment, the tumor's median maximal diameter was 19 mm (2...
February 10, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29376195/efficacy-safety-and-outcome-of-frameless-image-guided-robotic-radiosurgery-for-brain-metastases-after-whole-brain-radiotherapy
#14
Laura-Nanna Lohkamp, Peter Vajkoczy, Volker Budach, Markus Kufeld
Estimating efficacy, safety and outcome of frameless image-guided robotic radiosurgery for the treatment of recurrent brain metastases after whole brain radiotherapy (WBRT). We performed a retrospective single-center analysis including patients with recurrent brain metastases after WBRT, who have been treated with single session radiosurgery, using the CyberKnife® Radiosurgery System (CKRS) (Accuray Inc., CA) between 2011 and 2016. The primary end point was local tumor control, whereas secondary end points were distant tumor control, treatment-related toxicity and overall survival...
May 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29363282/to-frame-or-not-to-frame-cone-beam-ct-based-analysis-of-head-immobilization-devices-specific-to-linac-based-stereotactic-radiosurgery-and-radiotherapy
#15
Steven Babic, Young Lee, Mark Ruschin, Fiona Lochray, Alex Lightstone, Eshetu Atenafu, Nic Phan, Todd Mainprize, May Tsao, Hany Soliman, Arjun Sahgal
PURPOSE: Noninvasive frameless systems are increasingly being utilized for head immobilization in stereotactic radiosurgery (SRS). Knowing the head positioning reproducibility of frameless systems and their respective ability to limit intrafractional head motion is important in order to safely perform SRS. The purpose of this study was to evaluate and compare the intrafractional head motion of an invasive frame and a series of frameless systems for single fraction SRS and fractionated/hypofractionated stereotactic radiotherapy (FSRT/HF-SRT)...
March 2018: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29326012/stereotactic-body-radiotherapy-sbrt-for-patients-with-locally-advanced-pancreatic-cancer-a-single-center-experience
#16
Raphaël Jumeau, Guila Delouya, David Roberge, David Donath, Dominic Béliveau-Nadeau, Marie-Pierre Campeau
INTRODUCTION: Despite advances in treatment, notably in systemic therapy, the prognosis of pancreatic adenocarcinoma (PADC) remains dismal. Stereotactic body radiotherapy (SBRT) is an emerging tool in the complex management of PADC. We review outcomes of SBRT for PADC at our institution. METHODS: We reviewed patients treated with SBRT for either unresectable PADC or locally recurrent PADC after surgery. Treatment was delivered using a robotic radiosurgery system with respiratory tracking...
April 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29300187/a-treatment-planning-comparison-between-a-novel-rotating-gamma-system-and-robotic-linear-accelerator-based-intracranial-stereotactic-radiosurgery-radiotherapy
#17
Muhammad M Fareed, Ahmed Eldib, Stephanie E Weiss, Shelly B Hayes, Jinsheng Li, Charlie C-M Ma
To compare the dosimetric parameters of a novel rotating gamma ray system (RGS) with well-established CyberKnife system (CK) for treating malignant brain lesions. RGS has a treatment head of 16 cobalt-60 sources focused to the isocenter, which can rotate 360° on the ring gantry and swing 35° in the superior direction. We compared several dosimetric parameters in 10 patients undergoing brain stereotactic radiosurgery including plan normalization, number of beams and nodes for CK and shots for RGS, collimators used, estimated treatment time, D 2 cm and conformity index (CI) among two modalities...
February 2, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29152420/treatment-planning-for-self-shielded-radiosurgery
#18
John R Adler, Achim Schweikard, Younes Achkire, Oliver Blanck, Mohan Bodduluri, Lijun Ma, Hui Zhang
A five degree of freedom, robotic, radiosurgical system dedicated to the brain is currently under development. In the proposed design, the machine is entirely self-shielded. The main advantage of a self-shielded system is the simplification of the system's installation, which can reduce the cost of radiosurgery. In this way, more patients can benefit from this minimally invasive and highly effective type of procedure. For technical reasons, space inside the shielded region is limited, which leads to constraints on the design...
September 8, 2017: Curēus
https://www.readbyqxmd.com/read/29131807/towards-frameless-maskless-srs-through-real-time-6dof-robotic-motion-compensation
#19
Andrew H Belcher, Xinmin Liu, Steven Chmura, Kamil Yenice, Rodney D Wiersma
Stereotactic radiosurgery (SRS) uses precise dose placement to treat conditions of the CNS. Frame-based SRS uses a metal head ring fixed to the patient's skull to provide high treatment accuracy, but patient comfort and clinical workflow may suffer. Frameless SRS, while potentially more convenient, may increase uncertainty of treatment accuracy and be physiologically confining to some patients. By incorporating highly precise robotics and advanced software algorithms into frameless treatments, we present a novel frameless and maskless SRS system where a robot provides real-time 6DoF head motion stabilization allowing positional accuracies to match or exceed those of traditional frame-based SRS...
November 13, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29105011/modern-robot-assisted-radiosurgery-of-cerebral-angiomas-own-experiences-system-comparisons-and-comprehensive-literature-overview
#20
Thomas Feutren, Andres Huertas, Julia Salleron, René Anxionnat, Serge Bracard, Olivier Klein, Didier Peiffert, Valérie Bernier-Chastagner
Cerebral arteriovenous malformations (AVMs) are rare vascular lesions potentially responsible for substantial neurological morbidity and mortality. Over the past four decades, radiosurgery has become a valid therapeutic option for many patients with small intracranial AVMs, but reports describing the use of robotic stereotactic radiosurgery (SRS) are rare. The purposes of this study are to describe the efficacy and toxicity of robotic SRS for AVMs and to review the literature. The reports of 48 consecutive patients treated with SRS were reviewed...
November 5, 2017: Neurosurgical Review
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