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https://www.readbyqxmd.com/read/28432294/genome-wide-identification-characterization-of-the-mads-box-gene-family-in-chinese-jujube-and-their-involvement-in-flower-development
#1
Liman Zhang, Jin Zhao, Chunfang Feng, Mengjun Liu, Jiurui Wang, Yafei Hu
MADS-box genes encode transcription factors that are involved in plant development control (particularly in floral organogenesis) and signal transduction pathways, though a comprehensive analysis of MADS-box family proteins in Chinese jujube (Ziziphus jujuba Mill.) is still missing. Here, we report a genome-wide analysis of the MADS-box gene family in Chinese jujube. Based on phylogenetic analyses, 52 jujube MADS-box genes were classified into 25 MIKC(C)-type, 3 MIKC(*)-type, 16 Mα, 5 Mβ and 3 Mγ genes. 37 genes were randomly distributed across all 12 putative chromosomes...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28431932/zbed3-as1-induces-chondrogenesis-of-human-synovial-fluid-mesenchymal-stem-cells
#2
Farong Ou, Kai Su, Jiadong Sun, Wenting Liao, Yu Yao, Youhua Zheng, Zhiguang Zhang
Human synovial fluid-derived mesenchymal stem cells (SFMSCs) have great potential for cartilage induction and are promising for cell-based strategies for articular cartilage repair. Many long non-coding RNAs (lncRNAs) regulate chondrogenesis of MSCs. We hypothesized that the divergent lncRNA ZBED3-AS1, which binds locally to chromatin, could promote the expression of zbed3, a novel Axin-interacting protein that activates Wnt/β-catenin signaling, involved in chondrogenesis. However, the function of ZBED3-AS1 in SFMSCs is unclear...
April 18, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28431042/cis-regulatory-divergence-in-gene-expression-between-two-thermally-divergent-yeast-species
#3
Xueying C Li, Justin C Fay
Gene regulation is a ubiquitous mechanism by which organisms respond to their environment. While organisms are often found to be adapted to the environments they experience, the role of gene regulation in environmental adaptation is not often known. In this study, we examine divergence in cis-regulatory effects between two Saccharomyces species, S. cerevisiae and S. uvarum, that have substantially diverged in their thermal growth profile. We measured allele specific expression (ASE) in the species' hybrid at three temperatures, the highest of which is lethal to S...
April 14, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/28430805/effect-of-the-glucocorticoid-receptor-antagonist-ru486-on-mk-801-induced-behavioural-sensitisation
#4
Emilia M Lefevre, Gregory A Medley, Timothy Reeks, Suzy Alexander, Thomas H J Burne, Darryl W Eyles
Stress is known to modulate sensitisation to repeated psychostimulant exposure. However, there is no direct evidence linking glucocorticoids and sensitisation achieved by repeated administration of the NMDA receptor antagonist MK-801. We tested the hypothesis that co-administration of RU486, a glucocorticoid receptor (GR) antagonist, prior to repeated daily MK-801 injections would block the expression of locomotor sensitisation due to its dual effects on corticosterone and dopamine. We employed a repeated MK-801 administration locomotor sensitisation paradigm in male Sprague Dawley rats...
2017: PloS One
https://www.readbyqxmd.com/read/28429100/conversion-of-hormone-and-her-2-receptor-in-metachronous-neck-metastases-from-breast-carcinoma
#5
Andreas Nauroth, Matthias Kalder, Marion Rössler, Gunnar Wichmann, Andreas Dietz, Susanne Wiegand
PURPOSE: Metastases are a common event in breast cancer. The expression of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER-2) is essential for therapy and prognosis, and their conversion during disease progression potentially affects the treatment regimen. The aim was to analyze the estrogen, progesterone and HER-2 receptor expression in primary tumors and metachronous neck metastases from patients with breast cancer. METHODS: A retrospective analysis of 27 patients with breast cancer and metachronous neck metastasis was performed...
April 20, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28424214/functional-conservation-and-divergence-among-homoeologs-of-taspl20-and-taspl21-two-sbp-box-genes-governing-yield-related-traits-in-hexaploid-wheat
#6
Bin Zhang, Weina Xu, Xia Liu, Xinguo Mao, Ang Li, Jingyi Wang, Xiaoping Chang, Xueyong Zhang, Ruilian Jing
Maintaining high and stable yields has become an increasing challenge in wheat breeding due to climate change. Although Squamosa-promoter binding protein (SBP)-box genes have important roles in plant development, very little is known about the actual biological functions of wheat SBP-box family members. Here, we dissect the functional conservation, divergence and exploitation of homoeologs of two paralogous TaSPL wheat loci during domestication and breeding. TaSPL20 and TaSPL21 were highly expressed in the lemma and palea...
April 19, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28419336/ip3r-mediated-ca2-signals-govern-hematopoietic-and-cardiac-divergence-of-flk1-cells-via-the-calcineurin-nfatc3-etv2-pathway
#7
Yi-Jie Wang, Jijun Huang, Wenqiang Liu, Xiaochen Kou, Huayuan Tang, Hong Wang, Xiujian Yu, Shaorong Gao, Kunfu Ouyang, Huang-Tian Yang
Ca2+ signals participate in various cellular processes with spatial and temporal dynamics, among which, inositol 1,4,5-trisphosphate receptors (IP3Rs)-mediated Ca2+ signals are essential for early development. However, the underlying mechanisms of IP3R-regulated cell fate decision remain largely unknown. Here we report that IP3Rs are required for the hematopoietic and cardiac fate divergence of mouse embryonic stem cells (mESCs). Deletion of IP3Rs (IP3R-tKO) reduced Flk1+/PDGFRα- hematopoietic mesoderm, c-Kit+/CD41+ hematopoietic progenitor cell population, and the colony-forming unit activity, but increased cardiac progenitor markers as well as cardiomyocytes...
April 13, 2017: Journal of Molecular Cell Biology
https://www.readbyqxmd.com/read/28418904/a-consensus-hemagglutinin-based-vaccine-delivered-by-an-attenuated-salmonella-mutant-protects-chickens-against-heterologous-h7n1-influenza-virus
#8
Kim Je Hyoung, Irshad Ahmed Hajam, John Hwa Lee
H7N3 and H7N7 are highly pathogenic avian influenza (HPAI) viruses and have posed a great threat not only for the poultry industry but for the human health as well. H7N9, a low pathogenic avian influenza (LPAI) virus, is also highly pathogenic to humans, and there is a great concern that these H7 subtypes would acquire the ability to spread efficiently between humans, thereby becoming a pandemic threat. A vaccine candidate covering all the three subtypes must, therefore, be an integral part of any pandemic preparedness plan...
March 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28417193/genome-wide-analysis-of-vq-motif-containing-proteins-in-moso-bamboo-phyllostachys-edulis
#9
Yujiao Wang, Huanlong Liu, Dongyue Zhu, Yameng Gao, Hanwei Yan, Yan Xiang
29 Moso bamboo VQ proteins were genome-wide identified for the first time, and bioinformatics analysis was performed to investigate phylogenetic relationships and evolutionary divergence. The qRT-PCR data show that PeVQ genes response to different stress treatments. Accumulating evidence suggests that VQ motif-containing proteins in rice (Oryza sativa), Arabidopsis (Arabidopsis thaliana), and maize (Zea mays) play fundamental roles in response to various biotic and abiotic stresses. However, little is known about the functions of VQ family proteins in Moso bamboo (Phyllostachys edulis)...
April 17, 2017: Planta
https://www.readbyqxmd.com/read/28416687/structural-and-functional-innovations-in-the-real-time-evolution-of-new-%C3%AE-%C3%AE-8-barrel-enzymes
#10
Matilda S Newton, Xiaohu Guo, Annika Söderholm, Joakim Näsvall, Patrik Lundström, Dan I Andersson, Maria Selmer, Wayne M Patrick
New genes can arise by duplication and divergence, but there is a fundamental gap in our understanding of the relationship between these genes, the evolving proteins they encode, and the fitness of the organism. Here we used crystallography, NMR dynamics, kinetics, and mass spectrometry to explain the molecular innovations that arose during a previous real-time evolution experiment. In that experiment, the (βα)8 barrel enzyme HisA was under selection for two functions (HisA and TrpF), resulting in duplication and divergence of the hisA gene to encode TrpF specialists, HisA specialists, and bifunctional generalists...
April 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28415971/an-evolutionarily-conserved-transcriptional-response-to-viral-infection-in-caenorhabditis-nematodes
#11
Kevin Chen, Carl J Franz, Hongbing Jiang, Yanfang Jiang, David Wang
BACKGROUND: Caenorhabditis elegans is a powerful model organism for probing many biological processes including host-pathogen interactions with bacteria and fungi. The recent identification of nematode viruses that naturally infect C. elegans and Caenorhabditis briggsae provides a unique opportunity to define host-virus interactions in these model hosts. RESULTS: We analyzed the transcriptional response of pathogen infected C. elegans and C. briggsae by RNA-seq...
April 17, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28412457/identification-and-expression-analysis-of-alternatively-spliced-new-transcript-isoform-of-bax-gene-in-mouse
#12
Mohammed Amir Husain, Hassan Mubarak Ishqi, Tarique Sarwar, Sayeed Ur Rehman, Mohammad Tabish
Bax, a pro-apoptotic member of Bcl-2 family regulates apoptosis through homodimerization/heterodimerization with Bcl-2. Bax-α is the only product of the Bax gene that has been extensively studied. Bax-α exists in inactive form and several conformational changes are required during apoptosis to activate it. Here, we have identified a novel transcript variant of Bax gene in mouse which contains alternatively spliced new first exon that is different from the first exon of previously reported transcript. Conceptual translation of new transcript encodes a protein (Bax-α1), having different N-terminus...
April 12, 2017: Gene
https://www.readbyqxmd.com/read/28411887/from-christian-de-duve-to-yoshinori-ohsumi-more%C3%A2-to-autophagy-than-just-dining-at-home
#13
REVIEW
Margaret M Harnett, Miguel A Pineda, Perle Latré de Laté, Russell J Eason, Sébastien Besteiro, William Harnett, Gordon Langsley
Christian de Duve first coined the expression "autophagy" during his seminal work on the discovery of lysosomes, which led to him being awarded the Nobel Prize in Physiology or Medicine in 1974. The term was adopted to distinguish degradation of intracellular components from the uptake and degradation of extracellular substances that he called "heterophagy". Studies until the 1990s were largely observational/morphological-based until in 1993 Yoshinori Oshumi described a genetic screen in yeast undergoing nitrogen deprivation that led to the isolation of autophagy-defective mutants now better known as ATG (AuTophaGy-related) genes...
February 2017: Biomedical Journal
https://www.readbyqxmd.com/read/28411468/nine-co-localized-cytochrome-p450-genes-of-the-cyp2n-cyp2ad-and-cyp2p-gene-families-in-the-mangrove-killifish-kryptolebias-marmoratus-genome-identification-and-expression-in-response-to-b-%C3%AE-p-bpa-op-and-np
#14
Jayesh Puthumana, Bo-Mi Kim, Chang-Bum Jeong, Duck-Hyun Kim, Hye-Min Kang, Jee-Hyun Jung, Il-Chan Kim, Un-Ki Hwang, Jae-Seong Lee
The CYP2 genes are the largest and most diverse cytochrome P450 (CYP) subfamily in vertebrates. We have identified nine co-localized CYP2 genes (∼55kb) in a new cluster in the genome of the highly resilient ecotoxicological fish model Kryptolebias marmoratus. Molecular characterization, temporal and tissue-specific expression pattern, and response to xenobiotics of these genes were examined. The CYP2 gene clusters were characterized and designated CYP2N22-23, CYP2AD12, and CYP2P16-20. Gene synteny analysis confirmed that the cluster in K...
March 31, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28409183/combination-of-il-10-and-il-2-induces-oligoclonal-human-cd4-t-cell-expansion-during-xenogeneic-and-allogeneic-gvhd-in-humanized-mice
#15
Sojan Abraham, Hua Guo, Jang-Gi Choi, Chunting Ye, Midhun Ben Thomas, Nora Ortega, Alok Dwivedi, N Manjunath, Guohua Yi, Premlata Shankar
IL-10 is a crucial anti-inflammatory cytokine which can also exert a seemingly divergent immunostimulatory effects under certain conditions. We found high levels of the cytokine in a xenogeneic GVHD model where NOD-scid IL2rγcnull (NSG) mice were transplanted with human PBMCs in presence of IL-2. Presence of exogenous IL-10 altered the kinetics of IL-2 induced human T cell reconstitution in vivo, showing an initial delay, followed by rapid expansion. Further, compared to IL-2 alone, treatment with IL-2 in combination with IL-10 increased survival in most animals and completely protected ∼20% of mice from GVHD...
April 2017: Heliyon
https://www.readbyqxmd.com/read/28408352/characterization-and-spatiotemporal-expression-of-gonadotropin-releasing-hormone-in-the-pacific-abalone-haliotis-discus-hannai
#16
Tae Ha Kim, Mi Ae Kim, Kyeong Seop Kim, Jae Won Kim, Han Kyu Lim, Jung Sick Lee, Young Chang Sohn
Gonadotropin-releasing hormone (GnRH) is a key neuropeptide regulating reproduction in humans and other vertebrates. Recently, GnRH-like cDNAs and peptides were reported in marine mollusks, implying that GnRH-mediated reproduction is an ancient neuroendocrine system that arose prior to the divergence of protostomes and deuterostomes. Here, we evaluated the reproductive control system mediated by GnRH in the Pacific abalone Haliotis discus hannai. We cloned a prepro-GnRH cDNA (Hdh-GnRH) from the pleural-pedal ganglion (PPG) in H...
April 11, 2017: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/28406615/redox-sensitive-marr-homologue-bifr-from-burkholderia-thailandensis-regulates-biofilm-formation
#17
Ashish Gupta, Stanley M Fuentes, Anne Grove
Biofilm formation by pathogenic Burkholderia species is a serious complication as it renders the bacteria resistant to antibiotics and host defenses. Using B. thailandensis, we report here a novel redox-sensitive member of the multiple antibiotic resistance regulator (MarR) protein family, BifR, which represses biofilm formation. BifR is encoded as part of the emrB-bifR operon; emrB-bifR is divergent to ecsC, which encodes a putative LasA protease. In Pseudomonas aeruginosa, LasA has been implicated in virulence by contributing to cleavage of elastase...
April 21, 2017: Biochemistry
https://www.readbyqxmd.com/read/28404850/stress-hormones-epinephrine-and-corticosterone-selectively-modulate-hsv-1-and-hsv-2-productive-infection-in-adult-sympathetic-but-not-sensory-neurons
#18
Angela M Ives, Andrea S Bertke
Herpes simplex viruses 1 and 2 (HSV-1 and HSV-2) infect and establish latency in peripheral neurons, from which they can reactivate to cause recurrent disease throughout the life of the host. Stress is associated with exacerbation of clinical symptoms and induction of recurrences in humans and animal models. The viruses preferentially replicate and establish latency in different subtypes of sensory neurons, as well as in neurons of the autonomic nervous system that are highly responsive to stress hormones. To determine if stress-related hormones modulate productive HSV-1 and HSV-2 infection within sensory and autonomic neurons, we analyzed viral DNA and production of viral progeny after treatment of primary adult murine neuronal cultures with the stress hormones epinephrine and corticosterone...
April 12, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28404792/toxoplasma-effectors-targeting-host-signaling-and-transcription
#19
REVIEW
Mohamed-Ali Hakimi, Philipp Olias, L David Sibley
Early electron microscopy studies revealed the elaborate cellular features that define the unique adaptations of apicomplexan parasites. Among these were bulbous rhoptry (ROP) organelles and small, dense granules (GRAs), both of which are secreted during invasion of host cells. These early morphological studies were followed by the exploration of the cellular contents of these secretory organelles, revealing them to be comprised of highly divergent protein families with few conserved domains or predicted functions...
July 2017: Clinical Microbiology Reviews
https://www.readbyqxmd.com/read/28403814/divergent-and-convergent-modes-of-interaction-between-wheat-and-puccinia-graminis-f-sp-tritici-isolates-revealed-by-the-comparative-gene-co-expression-network-and-genome-analyses
#20
COMPARATIVE STUDY
William B Rutter, Andres Salcedo, Alina Akhunova, Fei He, Shichen Wang, Hanquan Liang, Robert L Bowden, Eduard Akhunov
BACKGROUND: Two opposing evolutionary constraints exert pressure on plant pathogens: one to diversify virulence factors in order to evade plant defenses, and the other to retain virulence factors critical for maintaining a compatible interaction with the plant host. To better understand how the diversified arsenals of fungal genes promote interaction with the same compatible wheat line, we performed a comparative genomic analysis of two North American isolates of Puccinia graminis f. sp...
April 12, 2017: BMC Genomics
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