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https://www.readbyqxmd.com/read/29694369/wearable-sensors-detect-childhood-internalizing-disorders-during-mood-induction-task
#1
Ellen W McGinnis, Ryan S McGinnis, Jessica Hruschak, Emily Bilek, Ka Ip, Diana Morlen, Jamie Lawler, Nestor L Lopez-Duran, Kate Fitzgerald, Katherine L Rosenblum, Maria Muzik
There is a significant need to develop objective measures for identifying children under the age of 8 who have anxiety and depression. If left untreated, early internalizing symptoms can lead to adolescent and adult internalizing disorders as well as comorbidity which can yield significant health problems later in life including increased risk for suicide. To this end, we propose the use of an instrumented fear induction task for identifying children with internalizing disorders, and demonstrate its efficacy in a sample of 63 children between the ages of 3 and 7...
2018: PloS One
https://www.readbyqxmd.com/read/29694316/mindfulness-based-stress-reduction-in-adolescents-with-mental-disorders-a-randomised-clinical-trial
#2
Mª C Díaz-González, Carolina Pérez Dueñas, Araceli Sánchez-Raya, Juan A Moriana Elvira, Vicente Sánchez Vázquez
BACKGROUND: Currently, there is a strong movement to implement mindfulness interventions with young people. The objective of this randomised clinical trial was to assess the potential effects of a mindfulness-based stress reduction (MBSR) programme for adolescent outpatients in mental health facilities in Cordoba, Spain. METHOD: A total of 101 adolescents aged 13-16 years old, receiving psychological or psychiatric treatment for various disorders, were eligible for the study...
May 2018: Psicothema
https://www.readbyqxmd.com/read/29693497/ocular-neuromyotonia-case-reports-and-literature-review
#3
Anne-Catherine Stockman, Catherine Cassiman, Maria Dieltiëns, Hilde Janssens, Maria Van Lammeren, Liesbet Beelen, Veerle Van Bellinghen
Ocular neuromyotonia (ONM) is a rare eye movement disorder, presenting as a paroxysmal involuntary spasm of one or more extra-ocular muscles, that can persist for a few seconds up to several minutes. The phenomenon is caused by the contraction of an extra-ocular muscle, excited by a damaged nerve, which leads to delayed muscle relaxation. We present eight patients with this rare condition together with an overview of the literature on all published ONM cases. One of the presented cases is possibly secondary to hypovitaminosis D...
April 25, 2018: Strabismus
https://www.readbyqxmd.com/read/29693218/preventing-wernicke-encephalopathy-after-bariatric-surgery
#4
REVIEW
Erik Oudman, Jan W Wijnia, Mirjam van Dam, Laser Ulas Biter, Albert Postma
Half a million bariatric procedures are performed annually worldwide. Our aim was to review the signs and symptoms of Wernicke's encephalopathy (WE) after bariatric surgery. We included 118 WE cases. Descriptions involved gastric bypass (52%), but also newer procedures like the gastric sleeve. Bariatric WE patients were younger (median = 33 years) than those in a recent meta-analysis of medical procedures (mean = 39.5 years), and often presented with vomiting (87.3%), ataxia (84.7%), altered mental status (76...
April 24, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29692327/evaluation-of-the-effects-of-occlusal-splint-trigger-point-injection-and-arthrocentesis-in-the-treatment-of-internal-derangement-patients-with-myofascial-pain-disorders
#5
Itır Şebnem Bilici, Yusuf Emes, Buket Aybar, Serhat Yalçın
PURPOSE: In temporomandibular disorders (TMDs), unless splints are effective, combined therapies are performed. The aim of this study is to show the effectiveness of the local anaesthethic injections (trigger point injections) to the masticatory muscles. MATERIALS AND METHODS: The study was composed of TMD patients and the predictor variables were therapy combinations including stabilization splint (SS) therapy, SS+trigger point injection therapy (TPI) and arthrocentesis...
March 31, 2018: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29691318/control-of-motor-coordination-by-astrocytic-tonic-gaba-release-through-modulation-of-excitation-inhibition-balance-in-cerebellum
#6
Junsung Woo, Joo Ok Min, Dae-Si Kang, Yoo Sung Kim, Guk Hwa Jung, Hyun Jung Park, Sunpil Kim, Heeyoung An, Jea Known, Jeongyeon Kim, Insop Shim, Hyung-Gun Kim, C Justin Lee, Bo-Eun Yoon
Tonic inhibition in the brain is mediated through an activation of extrasynaptic GABAA receptors by the tonically released GABA, resulting in a persistent GABAergic inhibitory action. It is one of the key regulators for neuronal excitability, exerting a powerful action on excitation/inhibition balance. We have previously reported that astrocytic GABA, synthesized by monoamine oxidase B (MAOB), mediates tonic inhibition via GABA-permeable bestrophin 1 (Best1) channel in the cerebellum. However, the role of astrocytic GABA in regulating neuronal excitability, synaptic transmission, and cerebellar brain function has remained elusive...
April 24, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29690990/-movement-disorders-in-children-and-adolescents
#7
Asli Sena Kücükyildiz, Nanette Mol Debes, Liselotte Skov
Tourette syndrome, obsessive-compulsive disorder, ticlike compulsions and motoric stereotypies are all movement disorders, which start in childhood and can be difficult to differentiate. In this article, we have outlined the most important focus points on how to differentiate the conditions in order to diagnose correctly and in order to refer to proper treatment.
April 16, 2018: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29690816/is-motor-activity-during-cognitive-assessment-an-indicator-for-feigned-attention-deficit-hyperactivity-disorder-adhd-in-adults
#8
Anselm B M Fuermaier, Oliver Tucha, Janneke Koerts, Tabea S Send, Matthias Weisbrod, Steffen Aschenbrenner, Lara Tucha
OBJECTIVES: Several approaches, ranging from self-ratings of symptoms and impairments to objective neuropsychological testing, have been utilized during clinical evaluation in order to assess symptom and performance validity of individuals with attention-deficit/hyperactivity disorder (ADHD) in adulthood. Motor activity has not been considered yet in this context, which is surprising given that hyperactivity is a prominent characteristic of ADHD. Hence, the goal of the present study was to explore the incremental value of motor activity when assessing the credibility of individuals with adult ADHD at clinical evaluation...
April 25, 2018: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/29689338/the-ketogenic-diet-in-disease-and-development
#9
REVIEW
Denis Barry, Sarah Ellul, Lindsey Watters, David Lee, Robert Haluska, Robin White
The ketogenic diet, low in carbohydrates and high in fat, was initially designed to reduce seizure onset in epilepsy. More recent evidence has shown its effectiveness in the treatment of movement and psychological disorders, and in general health maintenance. The cellular significance of ketone body metabolism during development and in the adult central nervous system is being revealed; however, the effects of replacing glucose with ketone bodies as the brains primary energy source especially in pregnancy are not fully understood...
April 21, 2018: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/29689222/snare-complex-assembly-and-disassembly
#10
Tae-Young Yoon, Mary Munson
A fundamental hallmark of eukaryotic cells is their compartmentalization into functionally distinct organelles, including those of the secretory and endocytic pathways. Transport of cargo between these compartments and to/from the cell surface is mediated by membrane-bound vesicles and tubules. Delivery of cargo is facilitated by SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor)-mediated membrane fusion of vesicles with their target compartments. Vesicles contain a variety of cargos, including lipids, membrane proteins, signaling molecules, biosynthetic and hydrolytic enzymes, and the trafficking machinery itself...
April 23, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29686598/sleep-related-problems-as-a-nonmotor-symptom-of-dentatorubropallidoluysian-atrophy
#11
Hyeyun Kim, Ji Young Yun, Kyoung-Gyu Choi, Heasoo Koo, Hyun Jeong Han
Dentatorubropallidoluysian atrophy (DRPLA) is a neurodegenerative disease caused by an expansion of a cytosine-adenine-guanine (CAG) repeat encoding a polyglutamine tract in the atrophin-1 protein. Unlike other CAG repeat diseases, sleep related problems have not been reported in patients with DRPLA. There was a 65-year-old man and his family with DRPLA. They suffered from seizure, gait disturbance, and cognitive decline. The patients commonly showed dream enacting sleep disorder, insomnia. The results from overnight polysomnography showed rapid eye movement (REM) without atonia in patients with DRPLA...
April 23, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29685658/novel-founder-intronic-variant-in-slc39a14-in-two-families-causing-manganism-and-potential-treatment-strategies
#12
Lance H Rodan, Marissa Hauptman, Alissa M D'Gama, Anita E Qualls, Siqi Cao, Karin Tuschl, Fatma Al-Jasmi, Jozef Hertecant, Susan J Hayflick, Marianne Wessling-Resnick, Edward T Yang, Gerard T Berry, Andrea Gropman, Alan D Woolf, Pankaj B Agrawal
Congenital disorders of manganese metabolism are rare occurrences in children, and medical management of these disorders is complex and challenging. Homozygous exonic mutations in the manganese transporter SLC39A14 have recently been associated with a pediatric-onset neurodegenerative disorder characterized by brain manganese accumulation and clinical signs of manganese neurotoxicity, including parkinsonism-dystonia. We performed whole exome sequencing on DNA samples from two unrelated female children from the United Arab Emirates with progressive movement disorder and brain mineralization, identified a novel homozygous intronic mutation in SLC39A14 in both children, and demonstrated that the mutation leads to aberrant splicing...
April 6, 2018: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/29685067/antipsychotic-drug-induced-movement-disorders-a-forgotten-problem
#13
Tamara Pringsheim, Thomas R E Barnes
No abstract text is available yet for this article.
January 1, 2018: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/29685047/long-term-results-of-linaclotide-in-the-treatment-of-constipation-type-irritable-bowel-syndrome
#14
Fernando Geijo Martínez, Ana Sánchez Garrido, Héctor Marcos Prieto, Concepción Piñeiro Pérez, Ana Beatriz Prieto Bermejo, Alberto Álvarez Delgado, Antonio Velasco Guardado, Antonio Rodríguez Pérez
BACKGROUND: constipation-predominant irritable bowel syndrome (C-IBS) is a prevalent, complex and multifactorial disorder that represents a challenge in terms of diagnosis and therapeutic management. OBJECTIVE: to evaluate the effectiveness, safety and treatment satisfaction of linaclotide in C-IBS patients. METHODS: prospective, single-center and observational study conducted in patients diagnosed with C-IBS. The patients were treated with linaclotide (Constella®, Allergan Inc...
April 24, 2018: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29683523/white-matter-degeneration-profile-in-the-cognitive-cortico-subcortical-tracts-in-parkinson-s-disease
#15
Alexandru Hanganu, Jean-Christophe Houde, Vladimir S Fonov, Clotilde Degroot, Beatriz Mejia-Constain, Anne-Louise Lafontaine, Valérie Soland, Sylvain Chouinard, Louis D Collins, Maxime Descoteaux, Oury Monchi
BACKGROUND: In Parkinson's disease cognitive impairment is an early nonmotor feature, but it is still unclear why some patients are able to maintain their cognitive performance at normal levels, as quantified by neuropsychological tests, whereas others cannot. The objectives of this study were to perform a cross-sectional study and analyze the white matter changes in the cognitive and motor bundles in patients with Parkinson's disease. METHODS: Sixteen Parkinson's disease patients with normal cognitive performance, 19 with mild cognitive impairment (based on their performance of 1...
April 23, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29682419/inducible-nitric-oxide-synthase-nos2-knockout-mice-as-a-model-of-trichotillomania
#16
Plinio C Casarotto, Caroline Biojone, Karina Montezuma, Fernando Q Cunha, Samia R L Joca, Eero Castren, Francisco S Guimaraes
Background: Trichotillomania (TTM) is an impulse control disorder characterized by repetitive hair pulling/trimming. Barbering behavior (BB) observed in laboratory animals is proposed as a model of TTM. The neurobiological basis of TTM is unclear, but involves striatal hyperactivity and hypoactivation of the prefrontal cortex. Methods: In this study, we evaluated the BB in knockout mice for the inducible isoform of nitric oxide synthase (NOS2KO) and the consequences of silencing this enzyme in PC12 cell differentiation...
2018: PeerJ
https://www.readbyqxmd.com/read/29682131/the-efficiency-of-anterior-repositioning-splints-in-the-management-of-pain-related-to-temporomandibular-joint-disc-displacement-with-reduction
#17
Malgorzata Pihut, Malgorzata Gorecka, Piotr Ceranowicz, Mieszko Wieckiewicz
Background and Objective: Intra-articular temporomandibular disorders are often related to pain in the area of the temporomandibular joint, ear, and temple. The aim of the study was to investigate the efficiency of anterior repositioning splints in decreasing pain related to temporomandibular joint disc displacement with reduction. Methods: The research material consisted of 112 patients, aged 24 to 45 years, of both genders, who reported for treatment at the Consulting Room of Temporomandibular Joint Dysfunctions at the Jagiellonian University in Cracow between 2014 and 2016 due to pain in the area of the temporomandibular joint(s) and noise(s) of temporomandibular joint(s) present during jaw movements with comorbid contracture of masticatory muscles...
2018: Pain Research & Management: the Journal of the Canadian Pain Society
https://www.readbyqxmd.com/read/29682095/brain-responses-underlying-anthropomorphism-agency-and-social-attribution-in-autism-spectrum-disorder
#18
Carla J Ammons, Constance F Doss, David Bala, Rajesh K Kana
Background: Theory of Mind (ToM), the ability to attribute mental states to oneself and others, is frequently impaired in Autism Spectrum Disorder (ASD) and may result from altered activation of social brain regions. Conversely, Typically Developing (TD) individuals overextend ToM and show a strong tendency to anthropomorphize and interpret biological motion in the environment. Less is known about how the degree of anthropomorphism influences intentional attribution and engagement of the social brain in ASD...
2018: Open Neuroimaging Journal
https://www.readbyqxmd.com/read/29680498/sleep-eeg-spectral-power-is-correlated-with-subjective-objective-discrepancy-of-sleep-onset-latency-in-major-depressive-disorder
#19
Seung-Gul Kang, Sara Mariani, Stephanie A Marvin, Kwang-Pil Ko, Susan Redline, John W Winkelman
We aimed to identify the sleep electroencephalography (EEG) spectral power correlates of the subjective-objective discrepancy (SOD) of sleep onset latency (SOL) in major depressive disorder (MDD), primary insomnia (PI), and normal sleeping control (NSC) groups. We examined relative power values in standard frequency bands of the EEG spectra during the first Non-Rapid Eye Movement (NREM) sleep period as correlates of SOD of SOL between sleep diary and polysomnography in MDD (n = 36), PI (n = 19), and NSC (n = 23) groups...
April 19, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29680423/nocturnal-sleep-architecture-in-idiopathic-hypersomnia-a-systematic-review-and-meta-analysis
#20
David T Plante
BACKGROUND: Current sleep medicine nosology places increased importance on nocturnal polysomnographic sleep recordings in the diagnosis of central nervous system disorders of hypersomnolence, particularly idiopathic hypersomnia (IH). OBJECTIVE: Determine what differences in sleep staging and architecture exist between IH and healthy controls using meta-analysis. METHODS: Systematic review identified relevant studies that included nocturnal polysomnography data for IH and healthy control groups...
May 2018: Sleep Medicine
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