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https://www.readbyqxmd.com/read/28934609/quantitative-measurement-of-sodium-polystyrene-sulfonate-adsorption-onto-ctab-capped-gold-nanoparticles-reveals-hard-and-soft-coronas
#1
Celina M Harris, Savannah G Miller, Kurt Andresen, Lucas B Thompson
Accumulated evidence indicates that nanoparticle behavior in complex biological environments strongly depends on the nanoparticles' surface chemistry. A common way to modify nanoparticles is to deposit oppositely charged molecules on the surfaces in a Layer-by-Layer fashion to build up thin films of polymers. While this polymer coating is a well-developed technique, the quantification of polymers deposited and physical mechanism of polymer deposition remain relatively unstudied. In this work CTAB capped gold nanoparticles, synthesized in a flow reactor, are coated with sodium polystyrene sulfonate and purified through a series of equilibrium dialysis steps...
September 9, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28933795/microfluidic-production-of-nanoscale-perfluorocarbon-droplets-as-liquid-contrast-agents-for-ultrasound-imaging
#2
Xiaonan Xu, Ruyuan Song, Minghao He, Chuan Peng, Miao Yu, Youmin Hou, Huihe Qiu, Ruhai Zou, Shuhuai Yao
Liquid perfluorocarbon (PFC) nanodroplets may have a better chance to extravasate through inter-endothelial gaps (400-800 nm) into tumor interstitium for extravascular imaging, which holds promise as an innovative strategy for imaging-guided drug delivery, early diagnosis of cancer and minimally invasive treatment of cancer. Currently available emulsion technologies still face challenges in reducing droplet sizes from the microscale to the nanoscale. To control size and ensure monodispersity of PFC nanodroplets, we developed a flame-shaped glass capillary and polydimethylsiloxane (PDMS) hybrid device that creates a concentric flow of the dispersed phase enclosed by the focusing continuous phase at the cross-junction...
September 21, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28930353/interplay-between-bulk-self-assembly-interfacial-and-foaming-properties-in-a-catanionic-surfactant-mixture-of-varying-composition
#3
José Ferreira, Alesya Mikhailovskaya, Alexis Chenneviere, Frédéric Restagno, Fabrice Cousin, François Muller, Jéril Degrouard, Anniina Salonen, Eduardo F Marques
The self-aggregation, surface properties and foamability of the catanionic surfactant mixture cetyltrimethylammonium bromide (CTAB)/sodium octyl sulfonate (SOSo) have been investigated to obtain insight on the relation between bulk nanostructures, surfactant packing, and foam stability and aging. Light microscopy, SANS, cryo-TEM, DLS, surface tension, rheometry and direct photography were used to characterize mixtures with varying CTAB molar fraction, xCTAB. In the bulk, self-assembly is richer in the excess CTAB region than in the excess SOSo one...
September 20, 2017: Soft Matter
https://www.readbyqxmd.com/read/28928892/the-targeted-antitumor-effects-of-c-pc-cmc-cd59sp-nanoparticles-on-hela-cells-in-vitro-and-in-vivo
#4
Yujuan Wang, Liangqian Jiang, Qifeng Yin, Huihui Liu, Guoxiang Liu, Guoteng Zhu, Bing Li
The novel C-PC/CMC-CD59sp-NPs were made by carbocymethyl chitosan (CMC) loading C-phycocyanin (C-PC) with the lead of CD59 specific ligand peptide (CD59sp) for targeting, and the characteristics and targeted anti-tumor mechanism were explored in order to realize the targeted therapy of C-PC on the growth of HeLa cells both in vitro and vivo. The targeting nanoparticles were synthesized by ionic-gelation method, and the optimal condition was selected out by orthogonal analysis. The properties of nanoparticles were observed by laser particle analyzer and dynamic light scattering (DLS) and Fourier Transform Infrared Spectrometer (FTIR)...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28928437/as1411-aptamer-anionic-linear-globular-dendrimer-g2-iohexol-selective-nano-theranostics
#5
Pardis Mohammadzadeh, Reza Ahangari Cohan, Seyedeh Masoumeh Ghoreishi, Ahmad Bitarafan-Rajabi, Mehdi Shafiee Ardestani
Molecular theranostics is of the utmost interest for diagnosis as well as treatment of different malignancies. In the present study, anionic linear globular dendrimer G2 is employed as a suitable carrier for delivery and AS1411 aptamer is exploited as the targeting agent to carry Iohexol specifically to the human breast cancer cells (MCF-7). Dendrimer G2 was prepared and conjugation of dendrimer and aptamer was carried out thereafter. Based on the data yielded by AFM, morphology of smooth and spherical non-targeted dendrimer changed to the rough aspherical shape when it conjugated...
September 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28925865/structural-changes-of-human-serum-albumin-hsa-in-simulated-microgravity
#6
Azadeh Hekmat, Zahra Hajebrahimi, Amir Motamedzade
Nowadays, the biological effects of microgravity have been the subject of various experimental researches. The purpose of this study was to investigate the probable biological effects of microgravity on the human serum albumin (HSA) structure after 3 and 24 h exposure via various spectroscopic instruments. The UV-Visible, near-UV-CD and intrinsic fluorescence spectroscopy represented that microgravity can remarkably change the tertiary structure of HSA. Additionally, the ANS affinity for HSA incremented when the protein was exposed to simulate microgravity compared to unexposed HSA, which may possibly have appeared attributable to expansion of the structure of simulated HSA...
September 17, 2017: Protein and Peptide Letters
https://www.readbyqxmd.com/read/28925709/effect-of-hydrophobic-chain-length-on-the-stability-and-guest-exchange-behavior-of-shell-sheddable-micelles-formed-by-disulfide-linked-diblock-copolymers
#7
Haiyan Fan, Yixia Li, Jinxian Yang, Xiaodong Ye
Reduction-responsive micelles hold enormous promise for the application as drug carriers due to the fast drug release triggered by reducing conditions and high anticancer activity. However, the effect of hydrophobic chain length on the stability and guest exchange of reduction-responsive micelles, especially for the micelles formed by diblock copolymers containing single disulfide group, are not fully understood. Here, shell-sheddable micelles formed by a series of disulfide-linked copolymer poly(ethylene glycol)-b-poly(-caprolactone) (PEG-SS-PCL) containing the same chain length of PEG but different chain lengths of hydrophobic block PCL were prepared and well characterized...
September 19, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28923702/zinc-oxide-nanoparticles-synthesis-antiseptic-activity-and-toxicity-mechanism
#8
REVIEW
A Król, P Pomastowski, K Rafińska, V Railean-Plugaru, B Buszewski
Zinc oxide (ZnO), as a material with attractive properties, has attracted great interest worldwide, particularly owing to the implementation of the synthesis of nano-sized particles. High luminescent efficiency, a wide band gap (3.36eV), and a large exciton binding energy (60meV) has triggered intense research on the production of nanoparticles using different synthesis methods and on their future applications. ZnO nanomaterials can be used in industry as nano-optical and nano-electrical devices, in food packaging and in medicine as antimicrobial and antitumor agents...
August 26, 2017: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/28921847/n-n-methylenebis-acrylamide-crosslinked-poly-acrylic-acid-particles-as-doxorubicin-carriers-a-comparison-between-release-behavior-of-physically-loaded-drug-and-conjugated-drug-via-acid-labile-hydrazone-linkage
#9
Seyedeh Mahnaz Modarresi-Saryazdi, Vahid Haddadi-Asl, Mehdi Salami-Kalajahi
N,N'-methylenebis(acrylamide) (MBA)-crosslinked poly(acrylic acid) (PAA) particles with low degree of crosslinking were synthesized using distillation precipitation polymerization (DPP). Size and size distribution of particles were obtained using DLS and FE-SEM and results showed that microspheres had a narrow size dispersity. (1) H NMR results indicated that amount of crosslinker in structure of particles is a little more than the molar percentage of feeded MBA due to greater activity ratio of MBA than AA...
September 18, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28920693/ph-tunable-and-divalent-metal-ion-tolerant-polymer-lipid-nanodiscs
#10
Thirupathi Ravula, Nathaniel Hardin, Sudheer Ramadugu, Ayyalusamy Ramamoorthy
The development and applications of detergent-free membrane mimetics have been the focus for the high-resolution structural and functional studies on membrane proteins. The introduction of lipid nanodiscs has attracted new attention towards the structural biology of membrane proteins and also enabled biomedical applications. Lipid nanodiscs provide a native lipid bilayer environment similar to the cell membrane surrounded by a belt made up of proteins or peptides. Recent studies have shown that the hydrolyzed form of styrene maleic anhydride copolymer (SMA) has the ability to form lipid nanodiscs and has several advantages over protein or peptide based nanodiscs...
September 18, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28919740/low-toxic-maghemite-nanoparticles-for-theranostic-applications
#11
Elena A Kuchma, Peter V Zolotukhin, Anna A Belanova, Mikhail A Soldatov, Tatiana A Lastovina, Stanislav P Kubrin, Anatoliy V Nikolsky, Lidia I Mirmikova, Alexander V Soldatov
BACKGROUND: Iron oxide nanoparticles have numerous and versatile biological properties, ranging from direct and immediate biochemical effects to prolonged influences on tissues. Most applications have strict requirements with respect to the chemical and physical properties of such agents. Therefore, developing rational design methods of synthesis of iron oxide nanoparticles remains of vital importance in nanobiomedicine. METHODS: Low toxic superparamagnetic iron oxide nanoparticles (SPIONs) for theranostic applications in oncology having spherical shape and maghemite structure were produced using the fast microwave synthesis technique and were fully characterized by several complementary methods (transmission electron microscopy [TEM], X-ray diffraction [XRD], dynamic light scattering [DLS], X-ray photoelectron spectroscopy [XPS], X-ray absorption near edge structure [XANES], Mossbauer spectroscopy, and HeLa cells toxicity testing)...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28917964/phenazopyridine-phthalimide-nano-cocrystal-release-rate-and-oral-bioavailability-enhancement
#12
Yu Huang, Jin-Mei Li, Zhi-Hui Lai, Jun Wu, Tong-Bu Lu, Jia-Mei Chen
Both cocrystal and nanocrystal technologies have been widely used in the pharmaceutical development for poorly soluble drugs. However, the synergistic effects due to the integration of these two technologies have not been well investigated. The aim of this study is to develop a nano-sized cocrystal of phenazopyridine (PAP) with phthalimide (PI) to enhance the release rate and oral bioavailability of PAP. A PAP-PI nano-cocrystal with particle diameter of 21.4±0.1nm was successfully prepared via a sonochemical approach and characterized by powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC), scanning electron microscopy (SEM) and dynamic light scattering (DLS) analysis...
September 14, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28916504/going-skin-deep-a-direct-comparison-of-penetration-potential-of-lipid-based-nanovesicles-on-the-isolated-perfused-human-skin-flap-model
#13
Selenia Ternullo, Louis de Weerd, Ann Mari Holsæter, Gøril Eide Flaten, Nataša Škalko-Basnet
Phospholipid-based nanocarriers are attractive drug carriers for improved local skin therapy. In the present study, the recently developed isolated perfused human skin flap (IPHSF) model was used to directly compare the skin penetration enhancing potential of the three commonly used nanocarriers, namely conventional liposomes (CLs), deformable liposomes (DLs) and solid lipid nanoparticles (SLNs). Two fluorescent markers, calcein (hydrophilic) or rhodamine (lipophilic), were incorporated individually in the three nanosystems...
September 12, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28914320/fabrication-of-metalosomes-metal-containing-cationic-liposomes-using-single-chain-surfactants-as-a-precursor-via-formation-of-inorganic-organic-hybrids
#14
Preeti Garg, Gurpreet Kaur, Ganga Ram Chaudhary, Santosh L Gawali, P A Hassan
Among the self-assembled forms of surfactants, vesicles/liposomes are a highly promising and interesting feature of surfactants, which are usually formed from water insoluble surfactants. Herein, we demonstrate the formation of liposomes from single-chain cationic surfactants with the help of metals as a part of the counter ion, and these metal embedded liposomes are termed as metalosomes. It is a noteworthy advancement in the area of self-assembled molecular structures since we report the preparation of metal embedded liposomes (metalosomes) from a water soluble single chain cationic surfactant, which is otherwise a property or an arrangement made by double tailed surfactants, or more precisely lipids that are poorly water soluble...
September 15, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28914197/characterization-of-inherent-particles-and-mechanism-of-thermal-stress-induced-particle-formation-in-hsv-2-viral-vaccine-candidate
#15
Lillian Li, Marina Kirkitadze, Kamaljit Bhandal, Cristopher Roque, Eric Yang, Bruce Carpick, Nausheen Rahman
BACKGROUND: Vaccine formulations may contain visible and/or subvisible particles, which can vary in both size and morphology. Extrinsic particles, which are particles not part of the product such as foreign contaminants, are generally considered undesirable and should be eliminated or controlled in injectable products. However, biological products, in particular vaccines, may also contain particles that are inherent to the product. Here we focus on the characterization of visible and subvisible particles in a live, replication-deficient viral vaccine candidate against HSV genital herpes in an early developmental stage...
September 14, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28913948/synthesis-of-size-tunable-hollow-polypyrrole-nanostructures-and-their-assembly-into-folate-targeting-and-ph-responsive-anti-cancer-drug-delivery
#16
Jian Chen, Xiufang Li, Yanhua Sun, Yuwei Hu, Yulong Peng, Yimin Li, Gang Yin, Hui Liu, Jiangfeng Xu, Shian Zhong
Chemotherapeutic drugs currently used in clinical settings have a high toxicity, low specificity, and short half-life. Herein, polypyrrole (PPy)-based anticancer drug nanocapsules were prepared by tailoring the nanoparticle size with a template method, controlling drug release by aromatic imine, increasing nanoparticle stability through PEGylation, and improving tumor cell selectivity via folate (FA) mediation. Nanoparticles were characterized by transmission electron microscopy (TEM) and dynamic light scattering (DLS)...
September 15, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28912680/fyn-signaling-is-compartmentalized-to-dopamine-d1-receptor-expressing-neurons-in-the-dorsal-medial-striatum
#17
Khanhky Phamluong, Emmanuel Darcq, Su Wu, Samuel A Sakhai, Dorit Ron
The tyrosine kinase Fyn plays an important role in synaptic plasticity, learning, and memory. Here we report that Fyn is activated in response to 15 min D1 receptor (D1R) but not D2 receptor (D2R) stimulation specifically in the dorsomedial striatum (DMS) of mice but not in the other substriatal regions, the dorsolateral striatum (DLS), and the nucleus accumbens (NAc). Once activated Fyn phosphorylates its substrate GluN2B, and we show that GluN2B is phosphorylated only in the DMS but not in the other striatal regions...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28910094/hemicellulosic-polysaccharides-mimics-synthesis-of-tailored-bottlebrush-like-xyloglucan-oligosaccharide-glycopolymers-as-binders-of-nanocrystalline-cellulose
#18
Jing Chen, Christophe Travelet, Redouane Borsali, Sami Halila
We report in this contribution that while low molecular weight hemicellulosic building blocks are known not to interact with cellulosic materials, their multivalent presentation on a polymeric scaffold significantly enhanced the binding interactions that are remarkably in the same range as those usually observed for lectin-carbohydrate interactions. We developed a poly(propargyl methacrylate) scaffold on which we conjugated, by "post-click" reaction, a variety of azide reducing-end functionalized xyloglucan oligosaccharides with controlled enzymatic-mediated rate of degalactosylation...
September 14, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28902225/optical-tracking-of-relaxation-dynamics-in-semi-dilute-hydroxypropylcellulose-solutions-as-a-precise-phase-transition-probe
#19
Hernan Garate, King-Wo Li, Denis Bouyer, Patrick Guenoun
Phase separation of thermo-responsive polymers in solution is a complex process, whose understanding is essential to screen and design materials with diverse technological applications. Here we report on a method based on dynamic light scattering (DLS) experiments to investigate the phase separation of thermo-responsive polymer solutions and precisely define the transition temperature (TPS). Our results are applied on hydroxypropylcellulose (HPC) solutions as an important biosourced green water-soluble polymer...
September 13, 2017: Soft Matter
https://www.readbyqxmd.com/read/28900640/pph4cl-in-aqueous-solution-the-aggregation-behavior-of-an-antagonistic-salt
#20
Robert Winkler, Thomas Buchecker, Florian Hastreiter, Didier Touraud, Werner Kunz
The initial definition of hydrotropy by Neuberg in 1916 describes a hydrotrope as a molecule which enhances the solubilization of hydrophobic substances in water. Sodium dodecyl sulfate (SDS) and sodium xylene sulfonate (SXS) are typical representatives fulfilling this old definition. They are either surfactants with a critical micellar concentration (CMC) or hydrotropes in the current sense of the term, showing a minimum hydrotrope concentration (MHC), respectively. In the present contribution, we consider the antagonistic salt PPh4Cl as a hydrotrope...
September 13, 2017: Physical Chemistry Chemical Physics: PCCP
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