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https://www.readbyqxmd.com/read/28812391/ph-sensitive-polymersomes-controlling-swelling-via-copolymer-structure-and-chemical-composition
#1
Simone Villani, Renata Adami, Ernesto Reverchon, Anna Maria Ferretti, Alessandro Ponti, Marilena Lepretti, Ivana Caputo, Lorella Izzo
pH-sensitive vesicles used as drug delivery systems (DDSs) are generally composed of protonable copolymers. The disaggregation of these nanoparticles (NPs) during drug release implies the dispersion of positively charged cytotoxic polyelectrolytes in the human body. To alleviate such issue, we synthesised A(BC)n amphiphilic block copolymers with linear (n = 1) and branched (n = 2) architectures to obtain pH-sensitive vesicles capable of releasing drugs in acidic conditions via controlled swelling instead of disaggregation...
August 16, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28810164/catalytic-oxidation-of-soot-on-mesoporous-ceria-based-mixed-oxides-with-cetyltrimethyl-ammonium-bromide-ctab-assisted-synthesis
#2
Hongjian Zhu, Jing Xu, Yuge Yichuan, Zhongpeng Wang, Yibo Gao, Wei Liu, Henan Yin
Mesoporous ceria and transition metal-doped ceria (M0.1Ce0.9O2 (M=Mn, Fe, Co, Cu)) catalysts were synthesized via CTAB-assisted method. The physicochemical properties of the prepared catalysts were characterized by XRD, DLS analysis, SEM, BET, Raman, H2-TPR and in situ DRIFT techniques. The catalytic activity tests for soot oxidation were performed under tight contact of soot/catalyst mixtures in the presence of O2 and NO+O2, respectively. The obtained results show that mesoporous ceria-based solid solutions can be formed with large surface areas and small crystallite size...
July 31, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28809539/polymersomes-with-endosomal-ph-induced-vesicle-to-micelle-morphology-transition-and-a-potential-application-for-controlled-doxorubicin-delivery
#3
Turgay Yildirim, Anja Traeger, Pelin Sungur, Stephanie Hoeppener, Carolin Kellner, Ilknur Yildirim, David Pretzel, Stephanie Schubert, Ulrich S Schubert
A series of pH responsive block copolymers were synthesized via the reversible addition-fragmentation chain transfer (RAFT) polymerization of 3,4-dihydro-2H-pyran (DHP) protected 2-hydroxyethyl methacrylate (HEMA) (2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl methacrylate (THP-HEMA)) and 2-(dimethylamino) ethyl methacrylate (DMAEMA) using p(THP-HEMA) as a macro chain transfer agent (mCTA). The degree of polymerization (DP) of the p(THP-HEMA) block was fixed to 35, whereas the DP of the p(DMAEMA) block was systematically varied from 21 to 50...
August 15, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28809468/construction-of-supramolecular-drug-drug-delivery-system-for-non-small-cell-lung-cancer-therapy
#4
Zhihao Zhang, Leilei Shi, Chenwei Wu, Yue Su, Jiwen Qian, Hongping Deng, Xinyuan Zhu
Nanoscale drug delivery systems (DDSs) are generally considered to be an effective alternative to small molecular chemotherapeutics due to the improved accumulation in tumor site and enhanced retention in blood. Nevertheless, most of DDSs have low loading efficiency or even pose high threat to normal organs caused by severe side effects. Ideally, supramolecular drug-drug delivery system (SDDDS) made up of pure drugs via supramolecular interaction provides a hopeful solution for cancer treatment. Herein, we put forward a facile method to construct SDDDS via co-assembly of Gefitinib (GEF) and tripeptide tyroservatide (YSV), two kinds of chemotherapeutic pharmaceuticals for non-small cell lung cancer (NSCLC), via multiple intermolecular interactions, including hydrogen bond and π-π stacking...
August 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28807691/size-optimization-and-in-vitro-biocompatibility-studies-of-chitosan-nanoparticles
#5
Thandapani Gomathi, P Supriya Prasad, P N Sudha, Sukumaran Anil
Chitosan (CS), an amino polysaccharide has fascinating scientific applications due to its many flexible properties. The advantages of Chitosan tend to increase when it was modified. Thus, in the present research work, to improve the properties of chitosan, it was converted into chitosan nanoparticles (CS-NPs) through the ionic gelation method using sodium tripoyphosphate (TPP) and sodium hexametaphosphate (SHMP) as a crosslinker. The size optimization was done by varying the parameters such as crosslinker concentration, agitation method and rate, agitation time, temperature and drying method...
August 11, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28807690/synergistic-effect-of-quercetin-and-ph-responsive-deae-chitosan-carriers-as-drug-delivery-system-for-breast-cancer-treatment
#6
Rafael de Oliveira Pedro, Francisco M Goycoolea, Susana Pereira, Carla C Schmitt, Miguel G Neumann
Amphiphilic chitosans, which may self-assemble in aqueous solution to form nanoaggregates with different conformations depending to the environmental pH, can be used as drug transport and delivery agents, when the target pH differs from the delivery medium pH. In this study, quercetin, a bioactive flavonoid, was encapsulated in a pH-responsive system based on amphiphilic chitosan. The hydrophilic reagent 2-chloro-N,N-diethylethylamine hydrochloride (DEAE), also known to inhibit the proliferation of cancer cells, was used as a grafting agent...
August 11, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28806683/asymmetric-polyplex-nanocapsules-loaded-with-photosentisizer-for-light-assisted-gene-transfer
#7
Xuemin Lu, Li Liu
Inefficient intracellular gene delivery is still a limitation for the clinical translation of gene therapy. Recently, photochemical internalization (PCI) has emerged with the opportunity to overcome endo-lysosomal sequestration in gene delivery, which utilizes photosensitizer (PS) plus light generating reactive oxygen species (ROS) at sub-lethal level to facilitate intracellularly targeted drug delivery. In this work, asymmetric polyplex-nanocapsules were prepared based on the triblock copolymers of PEG-PCL-PEI by using the simple solvent-injection method...
August 7, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28803977/a-comparison-of-canthaxanthine-pickering-emulsions-stabilized-with-cellulose-nanocrystals-of-different-origins
#8
Sheida Hedjazi, Seyed Hadi Razavi
Cellulosic nanocrystals from different origins were made to stabilize the canthaxanthin (CTX) in pickering emulsion. Nanocrystals were obtained by hydrochloric acid hydrolysis. Dynamic light scattering (DLS) demonstrated that the length of solid particles were in the range of 112nm to 4000nm. AFM indicated the needle-like shape of the cotton cellulose nanocrystals (CCNs) and bacterial cellulose nanocrystals (BCNs) and also illustrated the thickness of the particles to be 6 and 7nm respectively. The crystallinity of both BCNs and CCNs was higher than the cellulose source they were isolated (CL: 75...
August 10, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28803972/self-aggregation-behavior-of-hydrophobic-sodium-alginate-derivatives-in-aqueous-solution-and-their-application-in-the-nanoencapsulation-of-acetamiprid
#9
Xinyu Zhao, Jiacheng Li, Yuhong Feng, Gaobo Yu, Qingfeng Zhou, Furui He, Dunchao Xiao, Kai Chen, Lei Zhang
In this study, cholesteryl-grafted sodium alginate derivatives (CSAD) with different molecular weights were synthesized by esterification. The structure of CSAD was confirmed by FT-IR and (1)H NMR spectrometers. The effects of pH and CSAD polymer concentration on the self-assembled behavior and particle size of CSAD were investigated by fluorescence measurement (FM) and dynamic light scattering (DLS). In the presence of Ca(2+), the cholesteryl-grafted sodium alginate derivative was used for fabricating self-assembled nanoparticles that can effectively encapsulate the drug acetamiprid...
August 10, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28800465/oil-based-cyclo-oligosaccharide-nanodevices-for-drug-encapsulation
#10
Jennifer Noro, Ana Loureiro, Filipa Gonçalves, Nuno G Azoia, Seunho Jung, Carla Silva, Artur Cavaco-Paulo
New encapsulation nanodevices were synthesized by emulsification of cyclo-oligosaccharides fully substituted by hydrophobic palmitic chains. These highly hydrophobic compounds, acquire oily-like behaviour at moderate temperatures (∼50°C) and when submitted to ultrasound (US) can undergo emulsification. The improved emulsifying properties of modified cyclo-oligosaccharides are suitable to produce small and narrow sized nanoemulsions with ability to encapsulate amphiphilic molecules. Both encapsulation and delivery of a therapeutic drug, methotrexate (MTX), with amphiphilic character was assessed...
July 25, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28797811/biochemical-characterisation-of-lectin-from-indian-hyacinth-plant-bulbs-with-potential-inhibitory-action-against-human-cancer-cells
#11
Sanjay Naik, Ravindra Singh Rawat, Santripti Khandai, Mukesh Kumar, Sidhartha S Jena, Mookambeswaran A Vijayalakshmi, Sanjit Kumar
This work describes purification and characterisation of a monocot mannose-specific lectin from Hyacinth bulbs. The purified lectin has a molecular mass of∼30kDa in reducing as well as in non-reducing SDS-PAGE. In hydrodynamic studies by Dynamic Light Scattering (DLS) showed that purified lectin was monomeric in nature with a molecular size of 2.38±0.03nm. Agglutination activity of purified lectin was confirmed by rabbit erythrocytes and its agglutination activity was inhibited by D-mannose and glycoprotein (ovalbumin)...
August 7, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28797664/investigation-of-zinc-oxide-particles-in-cosmetic-products-by-means-of-centrifugal-and-asymmetrical-flow-field-flow-fractionation
#12
Vanessa Sogne, Florian Meier, Thorsten Klein, Catia Contado
The dimensional characterization of insoluble, inorganic particles, such as zinc oxide ZnO, dispersed in cosmetic or pharmaceutical formulations, is of great interest considering the current need of declaring the possible presence of nanomaterials on the label of commercial products. This work compares the separation abilities of Centrifugal- and Asymmetrical Flow Field-Flow Fractionation techniques (CF3 and AF4, respectively), equipped with UV-vis, MALS and DLS detectors, in size sorting ZnO particles, both as pristine powders and after their extraction from cosmetic matrices...
August 1, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28796046/effect-of-patient-position-on-the-lordosis-and-scoliosis-of-patients-with-degenerative-lumbar-scoliosis
#13
Han Fei, Wei-Shi Li, Zhuo-Ran Sun, Shuai Jiang, Zhong-Qiang Chen
This study aimed to analyze the effect of patient positions on the lordosis and scoliosis of patients with degenerative lumbar scoliosis (DLS).Seventy-seven patients with DLS were retrospectively analyzed. We measured lordosis and Cobb's angle on preoperative upright x-rays and magnetic resonance imagings in supine position. The lordosis and scoliosis of surgical segments in intraoperative prone position were measured on intraoperative radiographs of 20 patients to compare with that in standing position. Paired t tests were performed to investigate the parameters of the sample...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28795568/stable-superhydrophobic-porous-coatings-from-hybrid-abc-triblock-copolymers-and-their-anti-corrosive-performance
#14
Xin Zhou, Junhua Kong, Jiao-Tong Sun, Hui Li, Chaobin He
Superhydrophobic porous surfaces with ultra-low water adhesion were successfully fabricated via micelle fusion-aggregation assembly of newly designed linear hybrid ABC triblock copolymers, where A, B, and C denote poly(dimethylsiloxane) (PDMS), polystyrene (PS), and poly(methacrylolsobutyl polyhedral oligomeric silsesquioxane) (PiBuPOSSMA), respectively. It was found that aggregation behavior in diluted solution and subsequent formation of nano/microscale hierarchical surfaces in condensed state were affected by the molar mass of the triblock copolymers, which were evidenced by dynamic light scattering (DLS), SEM and TEM studies...
August 10, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28794934/activity-of-chitosan-lysozyme-nanoparticles-on-the-growth-membrane-integrity-and-%C3%AE-1-3-glucanase-production-by-aspergillus-parasiticus
#15
Cynthia Nazareth Hernández-Téllez, Francisco Julián Rodríguez-Córdova, Ema Carina Rosas-Burgos, Mario Onofre Cortez-Rocha, Armando Burgos-Hernández, Jaime Lizardi-Mendoza, Wilfrido Torres-Arreola, Aarón Martínez-Higuera, Maribel Plascencia-Jatomea
Synthesis of nanocomposites from antimicrobial biopolymers such as chitosan (CS) and lysozyme (LZ) is an important and promising area in bionanotechnology. Chitosan-lysozyme (CS-LZ) nanoparticles (NPs) were prepared by the nanoprecipitation method, using commercial chitosan of 153 kDa. TEM and dynamic light scattering (DLS) analysis were carried out to evaluate the morphology, size, dispersion, and Z potential. Association efficiency of lysozyme was determined using Coomassie blue assay. The antifungal activity of NPs against Aspergillus parasiticus was evaluated through cell viability (XTT), germination and morphometry of spores, and reducing sugars production; the effects on membrane integrity and cell wall were also analyzed...
October 2017: 3 Biotech
https://www.readbyqxmd.com/read/28794506/active-macromolecules-of-honey-form-colloidal-particles-essential-for-honey-antibacterial-activity-and-hydrogen-peroxide-production
#16
Katrina Brudzynski, Danielle Miotto, Linda Kim, Calvin Sjaarda, Liset Maldonado-Alvarez, Henryk Fukś
Little is known about the global structure of honey and the arrangement of its main macromolecules. We hypothesized that the conditions in ripened honeys resemble macromolecular crowding in the cell and affect the concentration, reactivity, and conformation of honey macromolecules. Combined results from UV spectroscopy, DLS and SEM showed that the concentration of macromolecules was a determining factor in honey structure. The UV spectral scans in 200-400 nm visualized and allowed quantification of UV-absorbing compounds in the following order: dark > medium > light honeys (p < 0...
August 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28792637/modulation-of-chondrocyte-motility-by-tetrahedral-dna-nanostructures
#17
Sirong Shi, Shiyu Lin, Xiaoru Shao, Qianshun Li, Zhang Tao, Yunfeng Lin
OBJECTIVES: Contemporarily, a highly increasing attention was paid to nanoconstructs, particularly DNA nanostructures possessing precise organization, functional manipulation, biocompatibility and biodegradability. Amongst these DNA nanomaterials, tetrahedral DNA nanostructures (TDNs) are a significantly ideal bionanomaterials with focusing on the property that can be internalized into cytoplasm in the absence of transfection. Therefore, the focus of this study was on investigating the influence of TDNs on the chondrocytes locomotion...
August 9, 2017: Cell Proliferation
https://www.readbyqxmd.com/read/28791599/comparison-of-nmr-and-dynamic-light-scattering-for-measuring-diffusion-coefficients-of-formulated-insulin-implications-for-particle-size-distribution%C3%A2-measurements-in-drug-products
#18
Sharadrao M Patil, David A Keire, Kang Chen
Particle size distribution, a measurable physicochemical quantity, is a critical quality attribute of drug products that needs to be controlled in drug manufacturing. The non-invasive methods of dynamic light scattering (DLS) and Diffusion Ordered SpectroscopY (DOSY) NMR can be used to measure diffusion coefficient and derive the corresponding hydrodynamic radius. However, little is known about their use and sensitivity as analytical tools for particle size measurement of formulated protein therapeutics. Here, DLS and DOSY-NMR methods are shown to be orthogonal and yield identical diffusion coefficient results for a homogenous monomeric protein standard, ribonuclease A...
August 8, 2017: AAPS Journal
https://www.readbyqxmd.com/read/28791210/biosynthesis-of-mgo-nanoparticles-using-mushroom-extract-effect-on-peanut-arachis-hypogaea-l-seed-germination
#19
K Jhansi, N Jayarambabu, K Paul Reddy, N Manohar Reddy, R Padma Suvarna, K Venkateswara Rao, V Ramesh Kumar, V Rajendar
Current study describes the green, environmental friendly, and cost-effectiveness technique for the preparation of MgO nanoparticles (NPs) via white button mushroom aqueous extract. The synthesized MgO NPs were characterized using equipments such as X-ray diffraction, dynamic light scattering (DLS), scanning electron microscope (SEM), energy dispersive spectroscopy (EDS), and thermal gravimetric analysis (TGA) for average crystalline size, particle size, morphology, elemental analysis, and weight loss of the materials, respectively...
August 2017: 3 Biotech
https://www.readbyqxmd.com/read/28791171/gold-nanoparticles-stabilized-with-sulphonated-imidazolium-salts-in-water-and-reverse-micelles
#20
Gustavo A Monti, Gabriela A Fernández, N Mariano Correa, R Darío Falcone, Fernando Moyano, Gustavo F Silbestri
Herein we describe the synthesis of gold nanoparticles (Au-NPs) in presence of sulphonated imidazolium salts [1,3-bis(2,6-diisopropyl-4-sodiumsulfonatophenyl)imidazolium (L1), 1-mesityl-3-(3-sulfonatopropyl)imidazolium (L2) and 1-(3-sulfonatopropyl)imidazolium (L3)] in water and in a confinement environment created by reverse micelles (RMs). The Au-NPs were characterized-with an excellent agreement between different techniques-by UV-vis spectroscopy, transmission electron microscopy (TEM), dynamic light scattering (DLS) and zeta potential...
July 2017: Royal Society Open Science
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