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https://www.readbyqxmd.com/read/28735008/trehalose-induced-structural-modulation-of-bovine-serum-albumin-at-ambient-temperature
#1
Ahana Das, Pijush Basak, Rudradip Pattanayak, Turban Kar, Rajib Majumder, Debadrita Pal, Anindita Bhattacharya, Maitree Bhattacharyya, Samudra Prosad Banik
Trehalose is a well-known protein stabilizing osmolyte. The present study has been designed to understand the interaction of trehalose with BSA at ambient temperature. Steady state fluorescence and life-time analysis along with CD, DLS and ITC have been employed to show that trehalose causes surface-associated structural perturbation of BSA to promote its compaction. Trehalose at 0.1M concentration resulted in increased solvent exposure of one of the two tryptophans of BSA with a 5nm redshift in emission and enhanced susceptibility to acrylamide quenching with an increase in KSV from 2...
July 19, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28734664/ph-responsive-biodegradable-nanogels-for-sustained-release-of-bleomycin
#2
Prashant Sahu, Sushil K Kashaw, Varun Kushwah, Samaresh Sau, Sanyog Jain, Arun K Iyer
Site specific drug delivery with desired therapeutic effect still remains challenging task due to suboptimal release, tissue toxicity, low selectivity and meager therapeutic efficacy in skin cancers. The aim of the current study was to fabricate pH responsive, self-assembled, chemically cross-linked biodegradable chitosan nanogel loaded with bleomycin to target the dermal area of the skin. The nanogel synthesized by ion gelation technique and was characterized for drug loading, swelling and thermal stability followed by in vitro analysis...
June 27, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28732937/dispersion-enhancing-effect-of-sonochemically-functionalized-graphene-oxide-for-catalysing-antioxidant-efficacy-of-curcumin
#3
Shrikant S Maktedar, Parth Malik, Gopal Avashthi, Man Singh
The non-hazardous sonochemical approach has been developed for the functionalization of graphene oxide (GrO) with 5-Aminoindazole (5-AIND). The formation of f-(5-AIND) GrO is confirmed with (13)C solid state NMR, HRXPS, XRD, Raman, TGA, DSC, FTIR etc. The >80% cell viabilities on MCF-7 and Vero cell lines have confirmed the high cytocompatibility of f-(5-AIND) GrO. Additionally, the morphological impact on Vero cell line has evidently confirmed the biocompatibility of f-(5-AIND) GrO. As compared to GrO, the f-(5-AIND) GrO has demonstrated an enhanced antioxidant efficacy of 69...
November 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28732161/an-elegant-ph-responsive-nanovehicle-for-drug-delivery-based-on-triazine-dendrimer-modified-magnetic-nanoparticles
#4
Amir Landarani-Isfahani, Majid Moghadam, Shima Mohammadi, Maryam Royvaran, Naimeh Moshtael-Arani, Saghar Rezaei, Shahram Tangestaninejad, Valiollah Mirkhani, Iraj Mohammadpoor-Baltork
Owing to properties of magnetic nanoparticles and elegant three-dimensional macromolecule architectural features, dendrimeric structures have been investigated as nanoscale drug delivery systems. In this paper, a novel magnetic nanocarrier, generation two (G2) triazine dendrimer modified Fe3O4@SiO2 magnetic nanoparticles (MNP-G2), was designed, fabricated and characterized by Fourier transform infrared (FT-IR), thermal gravimetric analysis (TGA), vibrating sample magnetometer (VSM), field emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM) and dynamic light scattering (DLS)...
July 21, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28731680/nitrilotriacetic-amine-functionalized-polymeric-core-shell-nanoparticles-as-enzyme-immobilization-supports
#5
Dominic Keller, Ana Beloqui, Monica Martínez-Martínez, Manuel Ferrer, Guillaume Delaittre
Nitrilotriacetic amine (NTA) functionalized nanoparticles obtained by aqueous polymerization-induced self-assembly (PISA) are introduced as immobilization supports for polyhistidine-functionalized (His-tagged) enzymes. A novel initiator for nitroxide-mediated polymerization based on the nitroxide SG1 and carrying a protected NTA moiety was first synthesized. Size-exclusion chromatography (SEC) and electrospray ionization mass spectrometry (ESI-MS) proved the ability of this initiator to produce well-defined end-functional vinyl polymers...
July 21, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28728004/effects-of-aspect-ratio-of-multi-walled-carbon-nanotubes-on-coal-washery-waste-water-treatment
#6
Ahmed Aliyu, Ishaq Kariim, Saka Ambali Abdulkareem
The dependency of adsorption behaviour on the aspect ratio of multi-walled carbon nanotubes (MWCNTs) has been explored. In this study, effect of growth temperature on yield and aspect ratio of MWCNTs by catalytic chemical vapour deposition (CCVD) method is reported. The result revealed that yield and aspect ratio of synthesised MWCNTs strongly depend on the growth temperature during CCVD operation. The resulting MWCNTs were characterized by High Resolution Transmission Electron Microscope (HRTEM), Dynamic Light Scattering (DLS) and X-ray diffraction (XRD) techniques to determine it diameter, hydrodynamic diameter and crystallinity respectively...
July 17, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28724292/adsorption-of-proteins-on-colloidal-lignin-particles-for-advanced-biomaterials
#7
Timo Leskinen, Joanna Witos, Juan José Valle Delgado, Kalle Sakari Lintinen, Mauri A Kostiainen, Susanne Kristina Wiedmer, Monika Österberg, Maija-Liisa Mattinen
Coating of colloidal lignin particles (CLPs), or lignin nanoparticles (LNPs), with proteins was evaluated in order to establish a safe, self-assembly-mediated modification technique to tune their surface chemistry. Gelatin and poly- L-lysine formed the most pronounced protein corona on the CLP surface, as determined by dynamic light scattering (DLS) and zeta potential measurements. Spherical morphology of individual protein coated CLPs was confirmed by transmission electron (TEM) and atomic force (AFM) microscopy...
July 19, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28723592/effects-of-near-infrared-radiation-on-dna-dls-and-atr-ftir-study
#8
Katarzyna Szymborska-Małek, Małgorzata Komorowska, Marlena Gąsior-Głogowska
We presume that the primary effect of Near Infrared (NIR) radiation on aqueous solutions of biological molecules concerns modification of hydrogen bonded structures mainly the global and the hydration shell water molecules. Since water has a significant influence on the DNA structure, we expect that the thermal stability of DNA could be modified by NIR radiation. The herring sperm DNA was exposed to NIR radiation (700-1100nm) for 5, 10, and 20min periods. The temperature dependent infrared measurements were done for the thin films formed on the diamond ATR crystal from evaporated DNA solutions exposed and unexposed to NIR radiation...
July 12, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28722404/high-performance-colorimetric-detection-of-thiosulfate-by-using-silver-nanoparticles-for-smartphone-based-analysis
#9
Chen Dong, Zhuqing Wang, Yujie Zhang, Xuehua Ma, M Zubair Iqbal, Lijing Miao, Zhuangwei Zhou, Zheyu Shen, Aiguo Wu
Developing thiosulfate (S2O32-) sensors with silver nanoparticles (AgNPs) for analysis of aqueous solutions with the interference of other anions remains challenging. In this study, we propose a new strategy for excellent selective colorimetric detection of S2O32-. The non-morphological transition of AgNPs leading to a color change from yellow to brown is verified by UV-vis, TEM, DLS, SEM, and XPS analyses. The sensor exhibits high sensitivity with detection limits of 1.0 µM by naked-eye determination and 0...
July 19, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28720002/green-synthesis-of-silver-nanoparticles-using-prosopis-juliflora-bark-extract-reaction-optimization-antimicrobial-and-catalytic-activities
#10
Geeta Arya, R Mankamna Kumari, Nidhi Gupta, Ajeet Kumar, Ramesh Chandra, Surendra Nimesh
In the present study, silver nanoparticles (PJB-AgNPs) have been biosynthesized employing Prosopis juliflora bark extract. The biosynthesis of silver nanoparticles was monitored on UV-vis spectrophotometer. The size, charge and polydispersity index (PDI) of PJB-AgNPs were determined using dynamic light scattering (DLS). Different parameters dictating the size of PJB-AgNPs were explored. Nanoparticles biosynthesis optimization studies suggested efficient synthesis of highly dispersed PJB-AgNPs at 25 °C when 9...
July 18, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28719858/interfacial-analysis-of-sirna-complexes-with-poly-ethylenimine-pei-or-pamam-dendrimers-in-gene-delivery
#11
Patrick K C Chang, Clive A Prestidge, Kristen E Bremmell
Solution and interfacial analysis has been employed to gain insight into the complexation of siRNA using either G4 PAMAM dendrimers or 25kDa branched poly-ethylenimine (bPEI). The size, charge and shape/structure of the complexing agents were probed using atomic force microscopy (AFM), circular dichroism spectrometry (CD), dynamic light scattering (DLS), and gel electrophoresis (GE). The binding capability of these cationic polymers to the siRNA molecule, subsequently controls the surface/adsorption behaviour of the complexes to a negatively charged surface...
July 8, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28719210/thermally-regulated-reversible-formation-of-vesicle-like-assemblies-by-hexaproline-amphiphiles
#12
Carles Felip-León, Francisco Galindo, Juan F Miravet, Valeria Castelletto, Ian W Hamley
Peptides composed of hexaproline and glutamic acid (P6E) or lysine (P6K) as C-terminal units show thermally promoted aggregation, affording vesicle-like assemblies upon heating to 80 ºC. The aggregation is analyzed by dynamic light scattering (DLS), with number averaged diameters of ca. 600 and 300 nm respectively for P6E and P6K. NMR studies reveal that upon heating the amount of NMR-visible species is reduced to ca. 50% and that an important conformational change is experienced by the molecules in solution...
July 18, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28715860/hemoglobin-bioconjugates-with-surface-protected-gold-nanoparticles-in-aqueous-media-the-stability-depends-on-solution-ph-and-protein-properties
#13
Rafael Del Caño, Lucia Mateus, Guadalupe Sánchez-Obrero, José Manuel Sevilla, Rafael Madueño, Manuel Blázquez, Teresa Pineda
The identification of the factors that dictate the formation and physicochemical properties of protein-nanomaterial bioconjugates are important to understand their behavior in biological systems. The present work deals with the formation and characterization of bioconjugates made of the protein hemoglobin (Hb) and gold nanoparticles (AuNP) capped with three different molecular layers (citrate anions (c), 6-mercaptopurine (MP) and ω-mercaptoundecanoic acid (MUA)). The main focus is on the behavior of the bioconjugates in aqueous buffered solutions in a wide pH range...
July 5, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28714853/unveiling-the-development-of-intracranial-injury-using-dynamic-brain-eit-an-evaluation-of-current-reconstruction-algorithms
#14
Haoting Li, Rongqing Chen, Canhua Xu, Benyuan Liu, Mengxing Tang, Lin Yang, Xiuzhen Dong, Feng Fu
Dynamic brain EIT is a promising technique for continuous monitoring the development of cerebral injury. While there are many reconstruction algorithms available to brain EIT, there is still a lack of study to compare their performance in the context of dynamic brain monitoring. To address the problem, we develop a framework for evaluating different current algorithms with their ability to correctly identify small intracranial conductivity changes. Firstly, a simulation 3D head phantom with realistic layered structure and impedance distribution were developed...
July 17, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28711858/size-distribution-of-extracellular-vesicles-by-optical-correlation-techniques
#15
Costanza Montis, Andrea Zendrini, Francesco Valle, Sara Busatto, Lucia Paolini, Annalisa Radeghieri, Annalisa Salvatore, Debora Berti, Paolo Bergese
Understanding the colloidal properties of extracellular vesicles (EVs) is key to advance fundamental knowledge in this field and to develop effective EV-based diagnostics, therapeutics and devices. Determination of size distribution and of colloidal stability of purified EVs resuspended in buffered media is a complex and challenging issue - because of the wide range of EV diameters (from 30 to 2000nm), concentrations of interest and membrane properties, and the possible presence of co-isolated contaminants with similar size and densities, such as protein aggregates and fat globules - which is still waiting to be fully addressed...
July 1, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28710928/synthesis-and-characterization-of-cobalt-supported-catalysts-on-modified-magnetic-nanoparticle-green-and-highly-efficient-heterogeneous-nanocatalyst-for-selective-oxidation-of-ethylbenzene-cyclohexene-and-oximes-with-molecular-oxygen
#16
Ali Reza Faraji, Sima Mosazadeh, Fatemeh Ashouri
In this study, a new supported cobalt nanocatalyst has been described. The Fe3O4 magnetic nanoparticles (Fe3O4 MNPs) modified by SiO2/aminopropyl trimethoxy silane/cyanuric chloride (Fe3O4@SiO2-APTMS/CC) utilized for anchoring metformin-cobalt complex (Fe3O4 Ms@SiO2-APTMS/CC/Met@Co(II)). The structure of novel complex well defined by elemental analysis, ICP, AAS, BET, FT-IR, EDX, SEM, TEM, DLS, XRD, TG-DTG, VSM and XPS. The catalytic efficiency of the synthesized cobalt nanocatalyst was studied in the oxidation of ethylbenzene (EB), cyclohexene (CYHE) and various oximes using molecular oxygen as ecofriendly oxidant and high catalytic activity and selectivity toward oxidation is observed...
June 30, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28707872/povidone-iodine-based-polymeric-nanoparticles-for-antibacterial-applications
#17
Tianyi Gao, Hongbo Fan, Xinjie Wang, Yangyang Gao, Wenxin Liu, Wanjun Chen, Alideertu Dong, Yan-Jie Wang
As microbial contamination is becoming more and more serious, antibacterial agents play an important role in preventing and removing bacterial pathogens from microbial pollution in our daily life. To solve water solubility and antibacterial stability of PVP-I2 as a strong antibacterial agent, we successfully obtain hydrophobic povidone-iodine nanoparticles (povidone-iodine NPs) by a two-step method related to the advantage of nanotechnology. Firstly, the synthesis of poly(N-vinyl-2-pyrrolidone-co-methyl methacrylate) nanoparticles, i...
July 14, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28707580/doxorubicin-loaded-micelle-targeting-muc1-a-potential-therapeutics-for-triple-negative-breast-cancer-treatment
#18
Supang Khondee, Chuda Chittasupho, Singkome Tima, Songyot Anuchapreeda
BACKGROUND: Triple negative breast cancer (TNBC) is an aggressive disease associated with poor prognosis and lack of validated targeted therapy. Thus chemotherapy is a main adjuvant treatment for TNBC patients, but it associates with severe toxicities. For a better treatment outcome, we developed an alternative therapeutic, doxorubicin (DOX)-loaded micelles targeting human mucin1 protein (MUC1) that is less toxic, more effective and targeted to TNBC. METHODS: From many candidate peptides, QNDRHPR-GGGSK (QND) and HSQLPQV-GGGSK (HSQ), were identified computationally, synthesized and purified using solid phase peptide synthesis and semi-preparative HPLC...
July 12, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28706191/aldehyde-dehydrogenase-1-positive-nigrostriatal-dopaminergic-fibers-exhibit-distinct-projection-pattern-and-dopamine-release-dynamics-at-mouse-dorsal-striatum
#19
Carmelo Sgobio, Junbing Wu, Wang Zheng, Xi Chen, Jing Pan, Armando G Salinas, Margaret I Davis, David M Lovinger, Huaibin Cai
Aldehyde dehydrogenase 1 (ALDH1A1)-positive dopaminergic (DA) neurons at the ventral substantia nigra pars compacta (SNpc) preferentially degenerate in Parkinson's disease (PD). Their projection pattern and dopamine release properties, however, remains uncharacterized. Here we show that ALDH1A1-positive axons project predominantly to the rostral two-thirds of dorsal striatum. A portion of these axons converge on a small fraction of striosome compartments restricted to the dorsolateral striatum (DLS), where less dopamine release was measured compared to the adjacent matrix enriched with the ALDH1A1-negative axons...
July 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28704805/biothiols-induced-colour-change-of-silver-nanoparticles-a-colorimetric-sensing-strategy
#20
Ambily Thomas, Unni Sivasankaran, Krishnapillai Girish Kumar
A sensor for the detection and determination of bio-thiols (glutathione (GSH) and cysteamine (Cyste)) has been developed by integrating the distinguished distance related optical characteristics of silver nanoparticles with the simplicity of colorimetric technique. In presence of these analytes, shift in surface plasmon resonance (SPR) absorption of silver nanoparticles (AgNPs) with change in its colour was observed. Yellow coloured AgNPs solution becomes colourless in presence of GSH and changes to red in presence of Cyste...
July 2, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
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