keyword
MENU ▼
Read by QxMD icon Read
search

dls

keyword
https://www.readbyqxmd.com/read/28212635/impact-of-semi-solid-formulations-on-skin-penetration-of-iron-oxide-nanoparticles
#1
Umberto M Musazzi, Benedetta Santini, Francesca Selmin, Valentina Marini, Fabio Corsi, Raffaele Allevi, Anna M Ferretti, Davide Prosperi, Francesco Cilurzo, Miriam Colombo, Paola Minghetti
BACKGROUND: This work aimed to provide useful information on the incidence of the choice of formulation in semi-solid preparations of iron-oxide nanoparticles (IONs). The appropriate analytical methods to assess the IONs physical stability and the effect of the semi-solid preparations on IONs human skin penetration were discussed. The physical stability of IONs (Dh = 31 ± 4 nm; ζ = -65 ± 5 mV) loaded in five semi-solid preparations (0.3% w/v), namely Carbopol gel (CP), hydroxyethyl cellulose gel (HEC), carboxymethylcellulose gel (CMC), cetomacrogol cream (Cet) and cold cream was assessed by combining DLS and low-field pulsed NMR data...
February 17, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28212595/preparation-and-characterization-of-gold-nanoparticles-in-the-presence-of-citrate-and-soybean-seed-extract-in-an-acidic-conditions
#2
Ebrahim Izadi, Ali Rasooli, Abolfazl Akbarzadeh, Soodabeh Davaran
Through the present study, an eco-friendly method was used to synthesize the gold nanoparticles (GNPs) by using the sodium citrate and extract of the soybean seed as reducing the agents at PH 3. X-Ray diffraction (XRD) method was used to evaluate the crystal structure of as-synthesized NPs and it's revealed that this method leads to well crystallized GNPs. In order to determine the particle size and their distribution, field emission scanning microscopy (FE-SEM) and dynamic light scattering (DLS) were used...
February 17, 2017: Drug Research
https://www.readbyqxmd.com/read/28207877/selective-inhibition-of-aggregation-fibrillation-of-bovine-serum-albumin-by-osmolytes-mechanistic-and-energetics-insights
#3
Moumita Dasgupta, Nand Kishore
Bovine serum albumin (BSA) is an important transport protein of the blood and its aggregation/fibrillation would adversely affect its transport ability leading to metabolic disorder. Therefore, understanding the mechanism of fibrillation/aggregation of BSA and design of suitable inhibitor molecules for stabilizing its native conformation, are of utmost importance. The qualitative and quantitative aspects of the effect of osmolytes (proline, hydroxyproline, glycine betaine, sarcosine and sorbitol) on heat induced aggregation/fibrillation of BSA at physiological pH (pH 7...
2017: PloS One
https://www.readbyqxmd.com/read/28199082/influence-of-solvent-on-the-structure-of-an-amphiphilic-block-copolymer-in-solution-and-in-formation-of-an-integral-asymmetric-membrane
#4
Maryam Radjabian, Clarissa Abetz, Birgit Fischer, Andreas Meyer, Volker Abetz
Nanoporous membranes with tailored size pores and multifunctionality derived from self-assembled block copolymers attract growing interest in ultrafiltration. The influence of the structure of block copolymer in the membrane casting solution on the formation of integral asymmetric isoporous block copolymer membranes using the nonsolvent induced phase separation process (NIPS) has been one of the long-standing questions in this research area. In this work we studied the principal role of the solvent on the micellization and self-assembly of asymmetric polystyrene-block-poly(4-vinylpyridine) (PS-b-P4VP) diblock copolymers by using a combination of dynamic light scattering (DLS) and small-angle X-ray scattering (SAXS)...
February 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28198589/synthesis-and-characterization-of-stimuli-responsive-star-like-polypept-o-ides-introducing-biodegradable-peptostars
#5
Regina Holm, Benjamin Weber, Philipp Heller, Kristina Klinker, Dana Westmeier, Dominic Docter, Roland H Stauber, Matthias Barz
Star-like polymers are one of the smallest systems in the class of core crosslinked polymeric nanoparticles. This article reports on a versatile, straightforward synthesis of three-arm star-like polypept(o)ide (polysarcosine-block-polylysine) polymers, which are designed to be either stable or degradable at elevated levels of glutathione. Polypept(o)ides are a recently introduced class of polymers combining the stealth-like properties of the polypeptoid polysarcosine with the functionality of polypeptides, thus enabling the synthesis of materials completely based on endogenous amino acids...
February 15, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/28197613/unusual-nanosized-associates-of-carboxy-calix-4-resorcinarene-and-cetylpyridinium-chloride-the-macrocycle-as-a-glue-for-surfactant-micelles
#6
Ju E Morozova, V V Syakaev, Ya V Shalaeva, A M Ermakova, I R Nizameev, M K Kadirov, A D Voloshina, V V Zobov, I S Antipin, A I Konovalov
The association of cetylpyridinium chloride (CPC) micelles in the presence of octaacetated tetraphenyleneoxymethylcalix[4]resorcinarene (CR) leads to the formation of unusual spherical supramolecular nanoparticles (SNPs). Within the range of CR/CPC molar ratios from 10/1 to 1/10 (except for 1/8), CR, acting as a counterion, decreases the critical micelle concentration of CPC by one order of magnitude and leads to the formation of SNPs with an average hydrodynamic radius of 164 nm and an average zeta potential of -60 mV...
February 15, 2017: Soft Matter
https://www.readbyqxmd.com/read/28196394/synthesis-and-evaluation-of-a-triblock-copolymer-zno-nanoparticles-from-poly-%C3%AE%C2%B5-caprolactone-and-poly-acrylic-acid-as-a-potential-drug-delivery-carrier
#7
Lida Ahmadkhani, Ali Baghban, Shahram Mohammadpoor, Rovshan Khalilov, Abolfazl Akbarzadeh, Taras Kavetskyy, Siamak Saghfi, Aygun N Nasibova
Through the present paper, a triblock copolymer containing pH-responsive (polyacrylic acid-b-polycaprolactone -b-polyacrylic acid) (PAA-b-PCL-b-PAA) was synthesized by using the ring-opening polymerization (ROP) of ε-caprolactone (ε-CL) and the reversible addition fragmentation chain transfer (RAFT) polymerization of the acrylic acid methods, as the drug carrier. Blends of the nanocrystalline zinc oxide nanoparticles (n-ZnO) and triblock copolymer treated from the solution have been used to make the hybrid polymer-metal oxide for the preparation of the drug loaded nanocomposite...
February 14, 2017: Drug Research
https://www.readbyqxmd.com/read/28195734/bovine-serum-albumin-adsorption-on-tio2-colloids-the-effect-of-particle-agglomeration-and-surface-composition
#8
Augusto Márquez, Thomas Berger, Andrea Feinle, Nicola Huesing, Martin Himly, Albert Duschl, Oliver Diwald
Protein adsorption at nanostructured oxides strongly depends on synthesis conditions and sample history of the material investigated. We measured the adsorption of bovine serum albumin (BSA) to commercial Aeroxide TiO2 P25 nanoparticles in aqueous dispersions. Significant changes in adsorption capacity were induced by mild sample washing procedures and attributed to the structural modification of adsorbed water and surface hydroxyls. Motivated by the lack of information about the sample history of commercial TiO2 nanoparticle samples we used vapor phase grown TiO2 nanoparticles, a well-established model system for adsorption and photo-catalysis studies, and performed on this material for the first time a systematic and quantitative BSA adsorption study...
February 14, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28195692/size-controlled-pd-nanoparticle-catalysts-prepared-by-galvanic-displacement-into-a-porous-si-iron-oxide-nanoparticle-host
#9
Taeho Kim, Xin Fu, David Warther, Michael J Sailor
Porous silicon nanoparticles containing both Pd and iron oxide nanoparticles are prepared and studied as magnetically recoverable catalysts for organic reductions. The Pd nanoparticles are generated in situ by electroless deposition of Pd(NH3)4(2+), where the porous Si skeleton acts as both a template and as a reducing agent and the released ammonia ligands raise the local pH to exert control over the size of the Pd nanoparticles. The nanocomposites are characterized by transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDS), nitrogen adsorption, X-ray diffraction (XRD), superconducting quantum interference device (SQUID) magnetization, and dynamic light scattering (DLS)...
February 14, 2017: ACS Nano
https://www.readbyqxmd.com/read/28193418/determination-of-the-total-cadmium-copper-lead-and-zinc-concentrations-and-their-labile-species-fraction-in-apple-beverages-by-flow-through-anodic-stripping-chronopotentiometry
#10
Dominika Jedryczko, Paweł Pohl, Maja Welna
An analytical procedure for operationally defined speciation of Cd, Cu, Pb and Zn in apple beverages by anodic stripping chronopotentiometry (ASCP) is presented. Optimal measurement conditions were set down to reliably determine the fraction of the labile metals species. The mean total concentrations of Cu, Pb and Zn were 69±20, 7.3±3.3, and 129±59μgL(-1) in apple juices, and 18±3, 4.2±0.1, 53±5μgL(-1) in apple drinks, respectively. The contributions of the fraction of the ASCP-labile species varied from 43 to 63% (Cu), from 32 to 42% (Pb) and from 38 to 58% (Zn)...
June 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28192984/diketopyrrolopyrrole-amphiphile-based-micelle-like-fluorescent-nanoparticles-for-selective-and-sensitive-detection-of-mercury-ii-ions-in-water
#11
Kaixuan Nie, Bo Dong, Huanhuan Shi, Zhengchun Liu, Bo Liang
A technique for encapsulating fluorescent organic probes in a micelle system offers an important alternative method to manufacture water-soluble organic nanoparticles (ONPs) for use in sensing Hg(2+). This article reports on a study of a surfactant-free micelle-like ONPs based on a 3,6-di(2-thienyl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione (TDPP) amphiphile, (2-(2-(2-methoxyethoxy)ethyl)-3,6-di(2-thiophyl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione (NDPP) fabricated to monitor Hg(2+) in water. NDPP was synthesized through a simple one-step modification of a commercially available dye TDPP with a flexible and hydrophilic alkoxy...
February 15, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28189113/monodisperse-mesoporous-silica-nanoparticles-of-distinct-topology
#12
Leilei Luo, Yucang Liang, Egil Sev Erichsen, Reiner Anwander
Monodisperse and uniform high-quality MCM(Mobil Composition of Matter)-48-type CMSNs (Cubic Mesoporous Silica Nanoparticles) are readily prepared by simply optimizing the molar ratio of ethanol and surfactant in the system TEOS-CTAB-NaOH-H2O-EtOH (TEOS=tetraethyl orthosilicate, CTAB=cetyltrimethylammonium bromide, EtOH=ethanol). In the absence of ethanol only hexagonal mesoporous silica with ellipsoidal and spherical morphology are obtained. The presence of ethanol drives a mesophase transformation from hexagonal to mixed hexagonal/cubic, further to purely cubic, and finally to a mixed cubic/lamellar...
January 31, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28187073/prolonged-preoperative-opioid-therapy-in-patients-with-degenerative-lumbar-stenosis-in-a-workers-compensation-setting
#13
Erik Y Tye, Joshua Anderson, Mhamad Faour, Arnold Haas, Rick Percy, Stephen T Woods, Uri M Ahn, Nicholas Ahn
STUDY DESIGN: Retrospective cohort study OBJECTIVE.: To investigate the impact of prolonged opioid use in the preoperative treatment plan of degenerative lumbar stenosis (DLS) SUMMARY OF BACKGROUND DATA.: Patients undergoing operative treatment for DLS with concomitant opioid use represent a clinically challenging population. The relative paucity of data on the relationship between preoperative opioid use and clinical outcomes in the Workers' compensation (WC) population necessitates further study of this unique population...
February 9, 2017: Spine
https://www.readbyqxmd.com/read/28185958/characterisation-of-aggregates-of-cyclodextrin-drug-complexes-using-taylor-dispersion-analysis
#14
Hadar Zaman, Andrew G Bright, Kevin Adams, David M Goodall, Robert T Forbes
There is a need to understand the nature of aggregation of cyclodextrins (CDs) with guest molecules in increasingly complex formulation systems. To this end an innovative application of Taylor dispersion analysis (TDA) and comparison with dynamic light scattering (DLS) have been carried out to probe the nature of ICT01-2588 (ICT-2588), a novel tumor-targeted vascular disrupting agent, in solvents including a potential buffered formulation containing 10% hydroxypropyl-β-cyclodextrin. The two hydrodynamic sizing techniques give measurement responses are that fundamentally different for aggregated solutions containing the target molecule, and the benefits of using TDA in conjunction with DLS are that systems are characterised through measurement of both mass- and z-average hydrodynamic radii...
February 6, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28185930/fabrication-of-letrozole-formulation-using-chitosan-nanoparticles-through-ionic-gelation-method
#15
Thandapani Gomathi, P N Sudha, J Annie Kamala Florence, Jayachandran Venkatesan, Sukumaran Anil
In this study, the anticancer drug letrozole (LTZ) was formulated using chitosan nanoparticles (CS-NPs) with the crosslinking agent sodium tripolyphosphate (TPP). The nano-formulation was optimized by varying the concentration of drug. The prepared particles were characterized using FTIR, TGA, XRD, SEM, TEM and DLS. From the FTIR results, the appearance of a new peak for CH, CC and CN confirms the formation of LTZ loaded chitosan nanoparticles. TEM images shows that the average particle size was in the range of 60-80nm and 20-40mm air dried and freeze dried samples respectively...
February 7, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28183640/preparation-characterization-and-drug-delivery-study-of-a-novel-nanobiopolymeric-multidrug-delivery-system
#16
Abbas Dadkhah Tehrani, Masoumeh Parsamanesh
New nanocarrier for codelivery of curcumin and doxorubicin as the anticancer drugs was synthesized using biocompatible and biodegradable materials. Firstly, an inclusion complex of amylose (Am) and curcumin (CUR) was formed through entrapment of curcumin into the amylose helices. Then the surface of amylose-curcumin (Am-CUR) complex was modified by polycaprolactone (PCL) via esterification reaction between hydroxyl functional groups of amylose and carbonyl groups of PCL. Finally, poly citric acid (PCA) reacted with terminal hydroxyl groups of PCL by esterification reaction...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28183626/stavudine-loaded-gelatin-liposomes-for-hiv-therapy-preparation-characterization-and-in-vitro-cytotoxic-evaluation
#17
Debasis Nayak, Ankita Boxi, Sarbani Ashe, Neethi Chandra Thathapudi, Bismita Nayak
Despite continuous research and availability of 25 different active compounds for treating chronic HIV-1 infection, there is no absolute cure for this deadly disease. Primarily, the residual viremia remains hidden in latently infected reservoir sites and persistently release the viral RNA into the blood stream. The study proposes the dual utilization of the prepared stavudine-containing nanoformulations to control the residual viremia as well as target the reservoir sites. Gelatin nanoformulations containing very low dosage of stavudine were prepared through classical desolvation process and were later loaded in soya lecithin-liposomes...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28183597/preparation-and-characterization-of-dox-loaded-keratin-nanoparticles-for-ph-gsh-dual-responsive-release
#18
Yanmei Li, Xuelian Zhi, Jiantao Lin, Xin You, Jiang Yuan
Smart drug carriers are the current need of the hour in controlled drug delivery applications. In this work, pH and redox dual responsive keratin based drug-loaded nanoparticles (KDNPs) were fabricated through two-step strategies. Keratin nanoparticles were first prepared by desolvation method and chemical crosslinking, followed by electrostatic adsorbing doxorubicin (DOX) to afford drug loaded keratin nanoparticles (KDNPs). The size, size distribution, and morphology of the KDNPs were characterized with dynamic light scattering (DLS) and Scan electronic microscope (SEM)...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28179102/impact-of-surface-grafting-density-of-peg-macromolecules-on-dually-fluorescent-silica-nanoparticles-used-for-the-in-vivo-imaging-of-subcutaneous-tumors
#19
Laurent Adumeau, Coralie Genevois, Lydia Roudier, Christophe Schatz, Franck Couillaud, Stéphane Mornet
BACKGROUND: In the context of systematically administered nanomedicines, the physicochemistry of NP surfaces must be controlled as a prerequisite to improve blood circulation time, and passive and active targeting. In particular, there is a real need to develop NP stealth and labelling for both in vivo and microscopic fluorescence imaging in a mice model. METHODS: We have synthesized NIR/red dually fluorescent silica nanoparticles of 19nm covalently covered by a PEG layer of different grafting density in the brush conformational regime by using a reductive amination reaction...
February 4, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28170255/dissolution-and-metastable-solution-of-cellulose-in-naoh-thiourea-at-8-%C3%A2-c-for-construction-of-nanofibers
#20
Zhiwei Jiang, Yan Fang, Yan-Ping Ma, Maili Liu, Ruigang Liu, Hongxia Guo, Ang Lu, Lina Zhang
To develop the facile approach for the cellulose dissolution, a novel solvent (9.3 wt% NaOH/7.4 wt% thiourea aqueous solution) was used, for the first time, to dissolve cellulose within 5 min at 8 °C. The results of nuclear magnetic resonance (NMR) and Raman spectra demonstrated that stable thiourea···OH(-) complexes formed through strong hydrogen bonds in NaOH/thiourea at room temperature. Moreover, the strength of the hydrogen bonds of thioureaOH complexes was much stronger than that of urea···OH(-) complexes, and the number of thiourea···OH(-) complexes increased significantly in 9...
February 7, 2017: Journal of Physical Chemistry. B
keyword
keyword
117658
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"