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https://www.readbyqxmd.com/read/28330154/inhibition-of-a-sulfate-reducing-bacterium-desulfovibrio-marinisediminis-gsr3-by-biosynthesized-copper-oxide-nanoparticles
#1
Kiana Alasvand Zarasvand, V Ravishankar Rai
To control the severe problem of microbiologically influenced corrosion, industries require highly potent antibacterial agent which can inhibit the growth of bacteria on man-made surfaces. This need drove the research towards the synthesis of nanoscale antimicrobial compounds. We, therefore, screened several bacteria for the biosynthesis of copper/copper compound nanoparticles which could inhibit the growth of Desulfovibrio marinisediminis, a sulfate reducing bacterium. Supernatant of thirty bacteria isolated from the biofilm formed on ship hull was mixed with 1 mM CuCl2 solution at room temperature...
June 2016: 3 Biotech
https://www.readbyqxmd.com/read/28327656/synthesis-of-norbornene-derived-helical-copolymer-by-simple-molecular-marriage-approach-to-produce-smart-nanocarrier
#2
Shivshankar R Mane, Ashlin Sathyan, Raja Shunmugam
A novel library of norbornene derived helical copolymer has been synthesized through the coupling of two homopolymers via Molecular Marriage Approach. The helicity is governed by the non-covalent interactions like hydrogen bonding, π-π stacking and the influence of hydrophobic and hydrophilic motifs. The detailed characterization of the copolymer (Copoly 1) has been provided and the super structures are confirmed through dynamic light scattering (DLS), scanning electron microscopy (SEM) and transmission electron microscopy (TEM)...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28327425/protein-drug-nanoconjugates-finding-the-alternative-proteins-as-drug-carrier
#3
Iqra Munir, Sadia Ajmal, Muhammad Raza Shah, Aftab Ahmad, Abdul Hameed, Syed Abid Ali
Present study was conducted to establish the interaction of bovine fetuin-A to validate its binding modalities with doxorubicin (Dox). Fetuin-A was purified to highest purity and monodispersity. Green synthesis of fetuin-A conjugated gold nanoparticles (F-GNPs) have been performed giving typical UV-maxima with subtle variation in fourier transform infrared spectroscopy (FTIR). Atomic force microscopy (AFM) revealed spherical shaped, polydisperse F-GNPs of varying sizes, complementing the radius of hydration (19...
March 18, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28323118/mixed-poly-vinyl-pyrrolidone-based-drug-loaded-nanomicelles-shows-enhanced-efficacy-against-pancreatic-cancer-cell-lines
#4
Anisha Veeren, Archana Bhaw-Luximon, Debabrata Mukhopadhyay, Dhanjay Jhurry
We report in this paper on the enhanced efficacy of a physical mixture of two single anti-cancer loaded nanomicelles against PANC-1 and BxPC-3. Poly(vinyl pyrrolidone-b-polycaprolactone) (PVP-b-PCL) and poly(vinyl pyrrolidone-b-poly(dioxanone-co-methyl dioxanone)) (PVP-b-P(DX-co-MeDX)) were synthesized and successfully loaded with various anti-cancer drugs - gemcitabine (GEM), doxorubicin.HCl (DOX.HCl), doxorubicin.NH2 (DOX), 5-fluorouracil (5-FU) and paclitaxel (PTX). Spherical micelles of size 160-477 nm were obtained as characterized by DLS while sizes determined by TEM were in the range 140-250 nm...
March 16, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28323099/nanohydrogel-with-n-n-bis-acryloyl-cystine-crosslinker-for-high-drug-loading
#5
Marcin Mackiewicz, Jan Romanski, Ewa Drozd, Beata Gruber-Bzura, Piotr Fiedor, Zbigniew Stojek, Marcin Karbarz
Substantially improved hydrogel particles based on poly(N-isopropylacrylamide) (pNIPA) have been obtained. First, as a result of replacing commercially available N,N'-bis(acryloyl)cystamine (BAC), the crosslinker, with acryloyl derivative of cystine containing a carboxylic group (BISS), the hydrogel particles acquired improved stability vs. ionic strength and allowed further chemical modification of the chains, including the attachment of drug molecules. Next, a redox-initiated aqueous precipitation polymerization via the semi-batch method was used...
March 18, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28322977/assessment-of-penetration-potential-of-ph-responsive-double-walled-biodegradable-nanogels-coated-with-eucalyptus-oil-for-the-controlled-delivery-of-5-fluorouracil-in-vitro-and-ex-vivo-studies
#6
Prashant Sahu, Sushil K Kashaw, Sanyog Jain, Samaresh Sau, Arun K Iyer
Penetration enhancers coated biodegradable polymeric nanogels loaded with cytotoxic drugs applied via the topical route, can be a promising strategy for improving the chemotherapeutic efficiency of skin cancers. The major objective of proposed research was to investigate the in vitro and ex vivo chemotherapeutic potential of double walled PLGA-chitosan biodegradable nanogel entrapped with 5-fluororuacil (5-FU) coated with eucalyptus oil, topically applied onto the skin. 5-FU was first entrapped in PLGA core by solvent evaporation technique followed by coating with cationic chitosan for ionic interaction with anionic skin cancer cell membrane...
March 17, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28320305/intermolecular-interactions-of-myosin-subfragment-1-induced-by-the-n-terminal-extension-of-essential-light-chain-1
#7
D S Logvinova, O P Nikolaeva, D I Levitsky
We applied dynamic light scattering (DLS) to compare aggregation properties of two isoforms of myosin subfragment 1 (S1) containing different "essential" (or "alkali") light chains, A1 or A2, which differ by the presence of an N-terminal extension in A1. Upon mild heating (up to 40°C), which was not accompanied by thermal denaturation of the protein, we observed a significant growth in the hydrodynamic radius of the particles for S1(A1), from ~18 to ~600-700 nm, whereas the radius of S1(A2) remained unchanged and equal to ~18 nm...
February 2017: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/28319816/dna-polyplexes-with-dendritic-glycopolymer-entrapped-gold-nanoparticles
#8
Jens Rumschöttel, Sabine Kosmella, Claudia Prietzel, Dietmar Appelhans, Joachim Koetz
Polyplexes, composed of Salmon DNA and very small gold nanoparticles embedded into a dendritic glycopolymer architecture of sugar-modified poly(ethyleneimine) (PEI-Mal) with a molar mass of about 25,000g/mol, were characterized by dynamic light scattering (DLS), zeta potential measurements, micro differential scanning calorimetry (μ-DSC) and transmission electron microscopy (TEM). The PEI-Mal-entrapped gold nanoparticles of about 2nm in diameter influence the polyplex formation of the hyperbranched PEI containing bulky maltose, and in consequence the DNA is more compactized in the inner part of spherical polyplex particles of about 150nm in diameter...
March 4, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28315770/biophysics-and-protein-corona-analysis-of-janus-cyclodextrin-dna-nanocomplexes-efficient-cellular-transfection-on-cancer-cells
#9
M Martínez-Negro, G Caracciolo, S Palchetti, D Pozzi, A L Capriotti, C Cavaliere, A Laganà, C Ortiz Mellet, J M Benito, J M García Fernández, E Aicart, E Junquera
The self-assembling processes underlining the capabilities of facially differentiated ("Janus") polycationic amphiphilic cyclodextrins (paCDs) as non-viral gene nanocarriers have been investigated by a pluridisciplinary approach. Three representative Janus paCDs bearing a common tetradecahexanoyl multitail domain at the secondary face and differing in the topology of the cluster of amino groups at the primary side were selected for this study. All of them compact pEGFP-C3 plasmid DNA and promote transfection in HeLa and MCF-7 cells, both in absence and in presence of human serum...
March 15, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28315735/very-rapid-amyloid-fibril-formation-by-a-bacterial-lipase-in-the-absence-of-a-detectable-lag-phase
#10
Fatemeh Rashno, Khosro Khajeh, Claudia Capitini, Reza H Sajedi, Maryam Monsef Shokri, Fabrizio Chiti
The conversion of proteins from their soluble states into well-organized amyloid fibrils has received abundant attention. This process typically consists of three stages: lag, growth and plateau phases. In this study, the process of amyloid fibril formation by lipase from Pseudomonas sp. after diluting out urea was examined by Thioflavin T (ThT) fluorescence, Congo red (CR) binding, 8-anilinonaphthalene-1-sulfonic acid (ANS) binding, dynamic light scattering (DLS), circular dichroism (CD) and Fourier transform infrared (FTIR) spectroscopies, X-ray diffraction (XRD) and transmission electron microscopy (TEM)...
March 15, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28315495/legumain-cleavable-4-arm-poly-ethylene-glycol-doxorubicin-conjugate-for-tumor-specific-delivery-and-release
#11
Huicong Zhou, Huanjiao Sun, Shixian Lv, Dawei Zhang, Xuefei Zhang, Zhaohui Tang, Xuesi Chen
Traditional chemotherapy strategy exists undesirable toxic side-effects to normal tissues due to the low selectively to cancer cells of micromolecule cytotoxic drugs. One considered method to realizing the targeted delivery and increasing the specificity to tumor tissues of the cytotoxic drug is to transporting and discharging it through an environment-sensitive mechanism. In this study, a novel enzyme-sensitive polymer-doxorubicin conjugate was designed to delivery chemotherapeutic drug in a tumor-specific behavior and selectively activated in tumor tissue...
March 14, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28302315/the-development-and-concurrent-validity-of-a-real-time-algorithm-for-temporal-gait-analysis-using-inertial-measurement-units
#12
E Allseits, J Lučarević, R Gailey, V Agrawal, I Gaunaurd, C Bennett
The use of inertial measurement units (IMUs) for gait analysis has emerged as a tool for clinical applications. Shank gyroscope signals have been utilized to identify heel-strike and toe-off, which serve as the foundation for calculating temporal parameters of gait such as single and double limb support time. Recent publications have shown that toe-off occurs later than predicted by the dual minima method (DMM), which has been adopted as an IMU-based gait event detection algorithm.In this study, a real-time algorithm, Noise-Zero Crossing (NZC), was developed to accurately compute temporal gait parameters...
February 21, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28301189/differential-effects-of-neural-inactivation-of-the-dorsolateral-striatum-on-response-and-latent-extinction
#13
Jarid Goodman, Amanda Gabriele, Mark G Packard
The present study examined the role of the dorsolateral striatum (DLS) in extinction behavior. Male Long-Evans rats were initially trained on the straight alley maze, in which they were reinforced to traverse a straight runway and retrieve food reward at the opposite end of the maze. After initial acquisition, animals were given extinction training using 1 of 2 distinct protocols: response extinction or latent extinction. For response extinction, the animal was released from the same starting position and had the opportunity to perform the originally reinforced approach response to the goal end of the maze, which no longer contained food...
April 2017: Behavioral Neuroscience
https://www.readbyqxmd.com/read/28294278/controlling-adsorption-and-passivation-properties-of-bovine-serum-albumin-on-silica-surfaces-by-ionic-strength-modulation-and-cross-linking
#14
Jae Hyeon Park, Tun Naw Sut, Joshua A Jackman, Abdul Rahim Ferhan, Bo Kyeong Yoon, Nam-Joon Cho
Understanding the physicochemical factors that influence protein adsorption onto solid supports holds wide relevance for fundamental insights into protein structure and function as well as for applications such as surface passivation. Ionic strength is a key parameter that influences protein adsorption, although how its modulation might be utilized to prepare well-coated protein adlayers remains to be explored. Herein, we investigated how ionic strength can be utilized to control the adsorption and passivation properties of bovine serum albumin (BSA) on silica surfaces...
March 15, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28293952/higher-pedot-molecular-weight-giving-rise-to-higher-thermoelectric-property-of-pedot-pss-a-comparative-study-of-cleviostm-p-and-cleviostm-ph1000
#15
Zeng Fan, Donghe Du, Hongyan Yao, Jianyong Ouyang
Poly(3,4-ethylenedioxuthiphene):poly(styrenesulfonate) (PEDOT:PSS) is a promising candidate as the next-generation thermoelectric (TE) material. Its TE properties are strongly dependent on its chemical and electronic structures. In this paper, we investigated the effect of PEDOT molecular weight on the TE properties of PEDOT:PSS films by a comparative study on two commercial grades of PEDOT:PSS, CleviosTM P and CleviosTM PH1000. Dynamic light scattering (DLS) and Raman spectra imply that the PEDOT of CleviosTM PH1000 possesses longer conjugated chains than that of CleviosTM P...
March 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28291743/lactobionic-acid-conjugated-tpgs-nanoparticles-for-enhancing-therapeutic-efficacy-of-etoposide-against-hepatocellular-carcinoma
#16
Altansukh Tsend-Ayush, Xiumei Zhu, Yu Ding, Jianxu Yao, Lifang Yin, Zhou Jianping, Jing Yao
Many effective anticancer drugs are limited to use for hepatocellular carcinoma (HCC) therapy due to drug resistance mechanisms in liver cells. In recent years, tumor-targeted drug delivery and inhibition of drug resistance-related mechanisms become an integrated strategy to combat effectively chemo-resistant cancer. Herein, lactobionic acid-conjugated D-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS-LA conjugate) was developed as a potential asialoglycoprotein receptor (ASGPR)-targeted nanocarrier and an efficient inhibitor of P-glycoprotein (P-gp) to enhance etoposide (ETO) efficacy against HCC...
March 14, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28290213/cardamom-fruits-as-a-green-resource-for-facile-synthesis-of-gold-and-silver-nanoparticles-and-their-biological-applications
#17
Veronika Soshnikova, Yeon Ju Kim, Priyanka Singh, Yue Huo, Josua Markus, Sungeun Ahn, Verónica Castro-Aceituno, Jongpyo Kang, Mohan Chokkalingam, Ramya Mathiyalagan, Deok Chun Yang
Gold (FA-AuNps) and silver (FA-AgNps) nanoparticles were synthesized at room temperature by aqueous extract of dried fruits of Amomum villosum, also known as Fructus Amomi (cardamom), in order to confer antioxidant, catalytic, antimicrobial activities and treatment effect against breast cancer cells. Fruit extracts served as both reducing agents and stabilizers in lieu of chemical agents. Ultra-violet visible (UV-Vis) spectroscopy, field emission transmission electron microscopy (FE-TEM), energy-dispersive X-ray (EDX) spectroscopy, elemental mapping, X-ray powder diffraction (XRD), selected area electron diffraction (SAED), dynamic light scattering (DLS) and Fourier transform infrared (FTIR) spectroscopy were employed to characterize the biosynthesized nanoparticles...
March 14, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28287501/evaluation-of-maltose-based-cationic-liposomes-with-different-hydrophobic-tails-for-plasmid-dna-delivery
#18
Bo Li, Liangliang Deng, Meiyan Liu, Youlin Zeng
In this paper, three cationic glycolipids with different hydrophobic chains Malt-DiC12MA (IX a), Malt-DiC14MA (IX b) and Malt-DiC16MA (IX c) were constructed by using maltose as starting material via peracetylation, selective 1-O-deacetylation, trichloroacetimidation, glycosylation, azidation, deacetylation, Staudinger reaction, tertiary amination and quaternization. Target compounds and some intermediates were characterized by ¹H-NMR, (13)C-NMR, ¹H-¹H COSY and ¹H-(13)C HSQC. The results of gel electrophoresis assay, atomic force microscopy images (AFM) and dynamic light scattering (DLS) demonstrate that all the liposomes could efficiently bind and compact DNA (N/P ratio less than 2) into nanoparticles with proper size (88 nm-146 nm, PDI < 0...
March 12, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28286944/multiresponsive-vesicles-composed-of-amphiphilic-azacalix-4-pyridine-derivatives
#19
Shi-Xin Fa, Xu-Dong Wang, Qi-Qiang Wang, Yu-Fei Ao, De-Xian Wang, Mei-Xiang Wang
Biomimicry of multiresponsive recognition of cell membrane with artificial membranes is challengeable. In this work, we designed azacalix[4]pyridine-based amphiphilic molecules 1 and 2. The self-assembly behaviors of 1 and 2 were investigated in aqueous medium. As demonstrated by DLS, SEM, TEM, and LSCM measurements, 1 formed stable vesicles (size 322 nm) in a mixture of THF/water, whereas 2 produced giant vesicles with decreased stability (size 928 nm). The vesicles composed of 1, with surface being engineered with the cavities of azacalix[4]pyridines, showed selective responses to a variety of guests including zinc ion, hydroquinone, and proton as monitored by DLS...
March 14, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28285062/self-assembled-stable-sponge-type-nanocarries-for-brucea-javanica-oil-delivery
#20
Aihua Zou, Yawen Li, Yiyin Chen, Angelina Angelova, Vasil M Garamus, Na Li, Markus Drechsler, Borislav Angelov, Yabin Gong
Sponge-type nanocarriers (spongosomes) are produced upon dispersion of a liquid crystalline sponge phase formed by self-assembly of an amphiphilic lipid in excess aqueous phase. The inner organization of the spongosomes is built-up by randomly ordered bicontinuous lipid membranes and their surfaces are stabilized by alginate chains providing stealth properties and colloidal stability. The present study elaborates spongosomes for improved encapsulation of Brucea javanica oil (BJO), a traditional Chinese medicine that may strongly inhibit proliferation and metastasis of various cancers...
February 27, 2017: Colloids and Surfaces. B, Biointerfaces
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