keyword
https://read.qxmd.com/read/38537201/prospective-evaluation-of-serum-free-thiols-in-inflammatory-bowel-disease-a-candidate-to-replace-c-reactive-protein-for-disease-activity-assessment
#1
JOURNAL ARTICLE
Anuj Bohra, Nicholas Batt, Krishneel Dutt, Pavel Sluka, Olga Niewiadomski, Abhinav Vasudevan, Daniel R Van Langenberg
BACKGROUND: Serum free thiols (SFTs) reflecting oxidative stress appear to correlate with inflammatory bowel disease (IBD) activity. We aimed to evaluate the performance of SFTs concentrations vs endoscopic and histological activity, compare SFTs with established biomarkers, and identify clinical and laboratory parameters independently associated with SFT levels in IBD patients. METHODS: Patients with confirmed IBD undergoing routine ileocolonoscopy for activity assessment were prospectively recruited, with serum samples obtained concurrently for SFTs and routine bloods, plus fecal calprotectin and immunochemical tests were collected ±30 days from ileocolonoscopy...
March 27, 2024: Inflammatory Bowel Diseases
https://read.qxmd.com/read/38537188/multimodal-ultrasonography-evaluation-in-thyroid-nodule-characterization-what-is-the-ideal-algorithm
#2
JOURNAL ARTICLE
Başak Erdemli Gürsel, Barış Çağlar, Rıfat Özpar, Özlem Saraydaroğlu, Gökhan Gökalp, Naile Bolca Topal
AIMS: The aim of this study is to investigate the diagnostic performances of Ultrasonography (US), Shear-wave Elastography (SWE), and Superb Microvascular Imaging (SMI) findings in the diagnosis of malignant thyroid nodules (MTNs) and to determine the US algorithm with the best diagnostic performance. MATERIAL AND METHODS: Eighty-one nodules in 77 patients who had underwent multimodal US with biopsy results, were evaluated. Echogenicity, nodule components, contours, presence and type of calcification, and size were analyzed with US...
March 27, 2024: Medical Ultrasonography
https://read.qxmd.com/read/38537186/can-the-width-of-lower-tongue-base-preoperative-sonography-measurements-predict-hypoxemia-during-esophagogastroduodenoscopy-under-sedation-in-asa-i-ii-patients
#3
JOURNAL ARTICLE
Hao Wu, Min Xia, Xu Chen, Sheng Wang, Wei Zhang
The most common complication during esophagogastroduodenoscopy (EGD) under sedation is hypoxemia. There is a scarcity of indicators to predict the risk of hypoxemia during EGD under sedation accurately. The width of the lower tongue base measured by ultrasound (US) is considered to be a significant predictor of the presence and severity of obstructive sleepapnea syndrome (OSAS), which develops hypoxemia by a similar mechanism to EGD under sedation. This study aimed to observe its ability to predict hypoxemia during EGD under sedation...
January 30, 2024: Medical Ultrasonography
https://read.qxmd.com/read/38537184/multiparametric-ultrasound-evaluation-of-liver-fibrosis-steatosis-and-viscosity-in-patients-with-chronic-liver-disease
#4
JOURNAL ARTICLE
Iulia Minciuna, Madalina Taru, Andreea Fodor, Oana Nicoara Farcau, Petra Fischer, Corina Radu, Monica Lupsor-Platon, Horia Stefanescu, Bogdan Procopet
AIMS: This study assessed the effectiveness of three ultrasound-based techniques (2D-SWE.PLUS, Att.PLUS, Vi.PLUS) for non-invasive evaluation of liver fibrosis, steatosis, and inflammation in chronic liver disease (CLD) patients.Materials and methods: Involving 209 consecutive compensated CLD patients, the study compared these ultrasound methods from Aixplorerwith standard Vibration-controlled Transient Elastography (VCTE) and Controlled Attenuation Parameter (CAP) from Fibroscan, alongside non-invasive serological markers...
February 7, 2024: Medical Ultrasonography
https://read.qxmd.com/read/38537183/a-radiomics-model-based-on-transrectal-ultrasound-for-predicting-prostate-cancer
#5
JOURNAL ARTICLE
Yanhua Huang, Hongwei Qian, Yuanyuan Zheng, Huiming Song, Xiatian Liu
AIM: Prostate cancer (PCa) is one of the most common neoplasms in men. However, the value of ultrasound-based radiomics for diagnosing PCa remains uncertain. MATERIAL AND METHODS: We retrospectively analyzed ultrasonic and clinical data from 373 patients. Patients were divided into two groups according to the pathological results. Radiomics features wereextracted from TRUS, and we screened the optimal features to construct radiomics models. Relationships between clinical characteristics and prostate lesions were identified by univariate and multivariate logistic regression analysis...
February 7, 2024: Medical Ultrasonography
https://read.qxmd.com/read/38537181/comparison-between-combined-ultrasounds-and-magnetic-resonance-imaging-in-the-differentiation-of-benign-and-malignant-breast-lesions-a-cross-sectional-study
#6
JOURNAL ARTICLE
Chaoxi Li, Dehui Wen, Haiyong Lu
AIM: To explore the performance of single or combined ultrasound (US) in diagnosing malignant breast lesions, and then compare the results with a magnetic resonance imaging (MRI) aspect. MATERIAL AND METHODS: Patients' demographics, tumor markers, and imaging examination were collected. Diagnostic models based on B-mode, color Doppler ultrasounds (CDU), strain elastography (SE), MRI, B-mode US + CDU, B-mode US + SE, and B-mode US + CDU + SE were developed using logistic regression analysis...
February 13, 2024: Medical Ultrasonography
https://read.qxmd.com/read/38537180/perfluorobutane-sonazoid-contrast-enhanced-ultrasound-to-diagnose-hepatocellular-carcinoma-a-systematic-review-and-meta-analysis
#7
REVIEW
Yujia Chen, Wenjun Zhu, Yunyun Yi, Huali Cao, Fan Chen, Qinling Zhu
AIM: This meta-analysis aimed to assess the precision of Sonazoid contrast-enhanced ultrasound (CEUS) to distinguish hepatocellular carcinoma (HCC) from focal liver lesions (FLLs). MATERIAL AND METHODS: The Cochrane Library, Embase, PubMed, and Web of Science databases were systematically searched and checked for studies using Sonazoid CEUS to characterize HCC. A comprehensive meta-analysis was conducted, involving data pooling, subgroup analyses, meta-regression, and investigation of publication bias...
February 25, 2024: Medical Ultrasonography
https://read.qxmd.com/read/38537150/prediction-of-occult-hemorrhage-in-the-lower-body-negative-pressure-model-initial-validation-of-machine-learning-approaches
#8
JOURNAL ARTICLE
Navid Rashedi, Yifei Sun, Vikrant Vaze, Parikshit Shah, Ryan Halter, Jonathan T Elliott, Norman A Paradis
INTRODUCTION: Detection of occult hemorrhage (OH) before progression to clinically apparent changes in vital signs remains an important clinical problem in managing trauma patients. The resource-intensiveness associated with continuous clinical patient monitoring and rescue from frank shock makes accurate early detection and prediction with noninvasive measurement technology a desirable innovation. Despite significant efforts directed toward the development of innovative noninvasive diagnostics, the implementation and performance of the newest bedside technologies remain inadequate...
March 27, 2024: Military Medicine
https://read.qxmd.com/read/38537077/nomogram-for-predicting-difficult-total-laparoscopic-hysterectomy-a-multi-institutional-retrospective-model-development-and-validation-study
#9
JOURNAL ARTICLE
Yin Chen, Jiahong Jiang, Min He, Kuiyan Zhong, Shuai Tang, Li Deng, Yanzhou Wang
BACKGROUND: Total laparoscopic hysterectomy (TLH) is the most commonly performed gynecological surgery. However, the difficulty of the operation varies depending on the patient and surgeon. Subsequently, patient's outcomes and surgical efficiency are affected. We aimed to develop and validate a pre-operative nomogram to predict the operative difficulty in patients undergoing TLH. METHODS: This retrospective study included 663 patients with TLH from XXX Hospital and 102 patients from YYY Hospital in Chongqing, China...
April 3, 2024: International Journal of Surgery
https://read.qxmd.com/read/38537059/an-mri-radiomics-approach-to-discriminate-hemorrhage-prone-intracranial-tumors-before-stereotactic-biopsy
#10
JOURNAL ARTICLE
Yupeng Zhang, Tingliang Cao, Haoyu Zhu, Yuqi Song, Changxuan Li, Chuhan Jiang, Chao Ma
PURPOSE: To explore imaging biomarkers predictive of intratumoral hemorrhage for lesions intended for elective stereotactic biopsy. METHOD: This study included a retrospective cohort of 143 patients with 175 intracranial lesions intended for stereotactic biopsy. All the lesions were randomly split into a training dataset (n=121) and a test dataset (n=54) at a ratio of 7:3. 34 lesions were defined as "hemorrhage-prone tumors" as hemorrhage occurred between initial diagnostic MRI acquisition and the scheduled biopsy procedure...
April 3, 2024: International Journal of Surgery
https://read.qxmd.com/read/38537008/impact-of-anthro-metabolic-indices-and-gestational-weight-gain-on-maternal-and-neonatal-outcomes-a-prospective-observational-study
#11
JOURNAL ARTICLE
Esra Keles, Leyla Kaya, Neşe Yakşi, Zahide Kaya, Önder Tosun
OBJECTIVE: The aim of this study was to examine the relationship of anthro-metabolic indices on maternal and neonatal outcomes. METHODS: This prospective observational study was conducted on healthy mother-baby pairs between January 1, 2023 and July 1, 2023. Detailed sociodemographic information was collected through an interview with the mother. Clinical, biochemical, obstetric, fetal, and neonatal outcomes were abstracted from hospital medical records. Anthropometric measurements were obtained from the examination of mother-baby pairs...
2024: Revista da Associação Médica Brasileira
https://read.qxmd.com/read/38536842/graphmhc-neoantigen-prediction-model-applying-the-graph-neural-network-to-molecular-structure
#12
JOURNAL ARTICLE
Hoyeon Jeong, Young-Rae Cho, Jungsoo Gim, Seung-Kuy Cha, Maengsup Kim, Dae Ryong Kang
Neoantigens are tumor-derived peptides and are biomarkers that can predict prognosis related to immune checkpoint inhibition by estimating their binding to major histocompatibility complex (MHC) proteins. Although deep neural networks have been primarily used for these prediction models, it is difficult to interpret the models reported thus far as accurately representing the interactions between biomolecules. In this study, we propose the GraphMHC model, which utilizes a graph neural network model applied to molecular structure to simulate the binding between MHC proteins and peptide sequences...
2024: PloS One
https://read.qxmd.com/read/38536822/immediate-postnatal-prediction-of-death-or-bronchopulmonary-dysplasia-among-very-preterm-and-very-low-birth-weight-infants-based-on-gradient-boosting-decision-trees-algorithm-a-nationwide-database-study-in-japan
#13
JOURNAL ARTICLE
Kota Yoneda, Tomohisa Seki, Yoshimasa Kawazoe, Kazuhiko Ohe, Naoto Takahashi
INTRODUCTION: Bronchopulmonary dysplasia (BPD) poses a substantial global health burden. Individualized treatment strategies based on early prediction of the development of BPD can mitigate preterm birth complications; however, previously suggested predictive models lack early postnatal applicability. We aimed to develop predictive models for BPD and mortality based on immediate postnatal clinical data. METHODS: Clinical information on very preterm and very low birth weight infants born between 2008 and 2018 was extracted from a nationwide Japanese database...
2024: PloS One
https://read.qxmd.com/read/38536802/predicting-successful-weaning-from-mechanical-ventilation-by-reduction-in-positive-end-expiratory-pressure-level-using-machine-learning
#14
JOURNAL ARTICLE
Seyedmostafa Sheikhalishahi, Mathias Kaspar, Sarra Zaghdoudi, Julia Sander, Philipp Simon, Benjamin P Geisler, Dorothea Lange, Ludwig Christian Hinske
Weaning patients from mechanical ventilation (MV) is a critical and resource intensive process in the Intensive Care Unit (ICU) that impacts patient outcomes and healthcare expenses. Weaning methods vary widely among providers. Prolonged MV is associated with adverse events and higher healthcare expenses. Predicting weaning readiness is a non-trivial process in which the positive end-expiratory pressure (PEEP), a crucial component of MV, has potential to be indicative but has not yet been used as the target...
March 2024: PLOS Digit Health
https://read.qxmd.com/read/38536658/development-of-diagnostic-algorithm-for-cushing-s-syndrome-a-tertiary-centre-experience
#15
JOURNAL ARTICLE
A Efthymiadis, H Loo, B Shine, T James, B Keevil, J W Tomlinson, A Pal, R Pofi
PURPOSE: No consensus exists as the gold standard for Cushing's Syndrome (CS) screening. This study aimed to evaluate the diagnostic accuracy and utility of late-night salivary cortisol (LNSC) and cortisone (LNSE), overnight dexamethasone suppression test (ODST), and urinary free cortisol (UFC) in developing a screening algorithm for CS. METHODS: A retrospective, single-centre analysis on 93 adult patients referred to the Oxford Centre for Diabetes, Endocrinology, and Metabolism for CS evaluation (2017-2022)...
March 27, 2024: Journal of Endocrinological Investigation
https://read.qxmd.com/read/38536642/clinical-prediction-model-for-primary-aldosteronism-subtyping-and-special-focus-on-adrenal-volumetric-assessment
#16
JOURNAL ARTICLE
Tugba Barlas, Erhan Turgut Ilgit, Mehmet Koray Akkan, Emetullah Cindil, Isil Imge Gultekin, Hulya Nur Sodan, Mehmet Muhittin Yalcin, Ethem Turgay Cerit, Sinan Sozen, Mujde Akturk, Fusun Toruner, Ayhan Karakoc, Alev Eroglu Altinova
PURPOSE: Our aim was to develop a prediction model based on a simple score with clinical, laboratory, and imaging findings for the subtype diagnosis of primary aldosteronism (PA). The contribution of adrenal volumetric assessment to PA subtyping was also investigated. METHODS: Thirty-five patients with adequate cannulation in adrenal venous sampling (AVS) were included. Laboratory data, the saline infusion test (SIT), and the AVS results of patients with PA were retrospectively evaluated...
March 27, 2024: Hormones: International Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/38536615/quantification-of-unencapsulated-drug-in-target-tissues-demonstrates-pharmacological-properties-and-therapeutic-effects-of-liposomal-topotecan-ff-10850
#17
JOURNAL ARTICLE
Toshifumi Kimura, Ken Okada, Yasushi Morohashi, Yukio Kato, Mikinaga Mori, Hiroshi Kato, Takeshi Matsumoto, Susumu Shimoyama
PURPOSE: Quantifying unencapsulated drug concentrations in tissues is crucial for understanding the mechanisms underlying the efficacy and safety of liposomal drugs; however, the methodology for this has not been fully established. Herein, we aimed to investigate the enhanced therapeutic potential of a pegylated liposomal formulation of topotecan (FF-10850) by analyzing the concentrations of the unencapsulated drug in target tissues, to guide the improvement of its dosing regimen. METHODS: We developed a method for measuring unencapsulated topotecan concentrations in tumor and bone marrow interstitial fluid (BM-ISF) and applied this method to pharmacokinetic assessments...
March 27, 2024: Pharmaceutical Research
https://read.qxmd.com/read/38536585/the-key-role-of-tumor-budding-in-predicting-the-status-of-lymph-node-involvement-in-early-gastric-cancer-patients-a-clinical-multicenter-validation-in-china
#18
JOURNAL ARTICLE
Xiangyu Wang, Xiuding Yang, Fenglin Cai, Mingzhi Cai, Yong Liu, Li Zhang, Rupeng Zhang, Fangqin Xue, Yan Sun, Jingyu Deng
BACKGROUND: Accurate preoperative prediction of lymph node (LN) involvement is essential for the management of early gastric cancer (EGC). Our objective was to formulate a potent nomogram for predicting LN involvement in EGC by leveraging an innovative predictor of tumor budding. METHODS: We assembled a cohort of EGC patients who underwent radical surgery at two tertiary cancer centers. Tumor budding was stratified by using an optimal cutoff value and integrated with other clinicopathological variables to ascertain the risk factors associated with LN involvement...
March 27, 2024: Annals of Surgical Oncology
https://read.qxmd.com/read/38536581/diagnostic-performance-of-ultrasound-in-the-assessment-of-gastric-contents-a-meta-analysis-and-systematic-review
#19
REVIEW
Xuanyuan Pan, Jun Chai, Xin Gao, Si Li, Jie Liu, Linxing Li, Yanjing Li, Zhichao Li
OBJECTIVE: To systematically analyze the accuracy of ultrasonic techniques in assessing the nature of gastric contents and their volume. METHODS: English-language articles that used ultrasonic techniques to assess the nature of gastric contents and their volume in patients were selected. In eligible studies, data were recalculated and analyzed for forest plots and subject summary curves of operating characteristics (SROC). Study quality was assessed using the diagnostic accuracy study quality assessment tool QUADAS-2...
March 27, 2024: Insights Into Imaging
https://read.qxmd.com/read/38536577/can-artificial-intelligence-detect-type-2-diabetes-in-women-by-evaluating-the-pectoral-muscle-on-tomosynthesis-diagnostic-study
#20
JOURNAL ARTICLE
Meltem M Yashar, Ilayda Begum Izci, Fatma Zeynep Gungoren, Abdulkadir A Eren, Ali A Mert, Irmak I Durur-Subasi
OBJECTIVES: This retrospective single-center analysis aimed to evaluate whether artificial intelligence can detect type 2 diabetes mellitus by evaluating the pectoral muscle on digital breast tomosynthesis (DBT). MATERIAL METHOD: An analysis of 11,594 DBT images of 287 consecutive female patients (mean age 60, range 40-77 years) was conducted using convolutional neural networks (EfficientNetB5). The inclusion criterion was left-sided screening images with unsuspicious interpretation who also had a current glycosylated hemoglobin A1c (HBA1c) % value...
March 27, 2024: Insights Into Imaging
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