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https://www.readbyqxmd.com/read/28724270/synergistic-effects-of-ad-libitum-low-dose-fructose-drinking-and-low-dose-streptozotocin-treatment-in-wistar-rats-a-mild-model-of-type-2-diabetes
#1
Asie Sadeghi, Maani Beigy, Samira Alizadeh, Hossein Mazloom, Sanaz Vakili, Saideh Ahmadi, Reza Meshkani
To develop a convenient animal model of T2D by pretreatment with low-dose 10% w/v fructose (FRC) solution followed by the injection of low doses of streptozotocin (STZ) in Wistar rats. For this 8-week experimental study; rats were first fed a standard chow ad-libitum diet and either tap water (n=40) or 10% w/v FRC solution (n=40) for 4 weeks. Next, rats in each category were randomly allocated to 4 subgroups (n=10 each) of low-dose STZ (25,35, and 45 mg/kg). The final mean fasting blood sugar (FBG) of FRC+STZ45 (197±55...
May 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28724181/finding-the-best-therapeutic-approach-for-pcos-the-importance-of-inositol-s-bioavailability
#2
B Orrù, R Circo, P Logoteta, S Petousis, G Carlomagno
Broadening clinical evidence has markedly designated inositol(s) as a common and effective therapeutic approach for PCOS and infertility. Although considerable research has been focused on the use in clinical practice of myo-inositol (myo-ins) and D-chiro-inositol (D-chiro-ins), the two major inositol stereoisomers, less attention has been paid to their bioavailability. Therefore, the aim of this paper is to gather and analyze information on inositol(s) bioavailability, to better delineate its optimal concentration for scientific and clinical purposes...
June 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28723886/prolonged-viral-replication-and-longitudinal-viral-dynamic-differences-among-respiratory-syncytial-virus-rsv-infected-infants
#3
Monica E Brint, Joshua M Hughes, Aditya Shah, Chelsea R Miller, Lisa G Harrison, Elizabeth A Meals, Jacqueline Blanch, Charlotte R Thompson, Stephania A Cormier, John P DeVincenzo
BACKGROUND: Longitudinal RSV dynamics have not been well-studied despite existence of factors favoring prolonged RSV replication including: high mutation rates allowing rapid evolution and potential escape from immune control. We therefore measured viral load in previously RSV-naïve infants over prolonged time-spans. METHODS: During 2014-2015, quantitative nasal aspirates were collected from 51 RSV-PCR+ infants. Multiple parallel assessments of viral loads were quantified at each collected time point using a well-validated real-time qRT-PCR assay...
July 19, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28723775/the-neutrophil-to-lymphocyte-ratio-could-be-a-good-diagnostic-marker-and-predictor-of-relapse-in-patients-with-adult-onset-still-s-disease-a-strobe-compliant-retrospective-observational-analysis
#4
Ji-Yeoun Seo, Chang-Hee Suh, Ju-Yang Jung, Ar-Reum Kim, Ji Won Yang, Hyoun-Ah Kim
The neutrophil-to-lymphocyte ratio (NLR) is the proportion of absolute neutrophil count to lymphocytes on routine complete blood count (CBC) tests, and has been studied as a simple marker of the systemic inflammatory response. This study was performed to investigate whether the NLR could be used as a tool to diagnose and predict prognosis in cases of adult-onset Still's disease (AOSD).We retrospectively reviewed 164 patients with suspected AOSD. Among 164 patients with suspected AOSD, 37 patients received another diagnosis (such as viral infection) and were compared with the 127 patients who received a diagnosis of AOSD...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28723763/the-diagnostic-value-of-assays-for-circulating-tumor-cells-in-hepatocellular-carcinoma-a-meta-analysis
#5
Chi Sun, Wenjun Liao, Zefu Deng, Enliang Li, Qian Feng, Jun Lei, Rongfa Yuan, Shubing Zou, Yilei Mao, Jianghua Shao, Linquan Wu, Chao Zhang
PURPOSE: Circulating tumor cells (CTCs) are considered potential biomarkers for the detection of hepatocellular carcinoma (HCC). Many studies have attempted to explore this role, but the results are variable. We conducted the first comprehensive meta-analysis to evaluate the diagnostic value of CTC assay for HCC patients. Additional prognostic value was also assessed. EXPERIMENTAL DESIGN: All articles included in our study were assessed using QUADAS guidelines after a literature search...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28723750/sphincter-preserving-surgery-for-low-middle-rectal-cancer-can-we-predict-feasibility-with-high-resolution-magnetic-resonance-imaging
#6
Hai-Bin Zhu, Lin Wang, Zi-Yu Li, Xiao-Ting Li, Xiao-Yan Zhang, Ying-Shi Sun
The study proposed to evaluate the feasibility of predicting sphincter-sparing surgery (SSS) preoperatively in low-middle rectal cancer by using magnetic resonance (MR).The study included both retrospective and prospective design. In the retrospective design, the distance from lower edge of tumor to upper margin of the internal sphincter (Dis1) and distance to anal verge (Dis2) were measured on MR, the distance to anal verge recorded by colonoscopy (Dis3) and digital rectal examination (Dis4) were also obtained...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28722795/influence-of-renal-function-on-anticoagulation-control-in-patients-with-non-valvular-atrial-fibrillation-taking-vitamin-k-antagonists
#7
José M Lobos-Bejarano, Angel Castellanos Rodríguez, Vivencio Barrios, Carlos Escobar, José Polo-García, José Carlos Del Castillo-Rodríguez, Diego Vargas-Ortega, Adriana Lopez-Pineda, Luis Prieto-Valiente, Gregory Y H Lip
BACKGROUND AND PURPOSE: Chronic kidney disease (CKD) has been related to poor anticoagulation control and an increased risk of bleeding. This study aims to evaluate the association between impaired renal function (eGFR <60 mL/min/1.73 m(2) ) and anticoagulation control in patients with non-valvular atrial fibrillation (AF) on vitamin K antagonists (VKA) therapy. We also assessed whether the predictive value of the SAMe-TT2 R2 score prevailed for subgroups both with and without CKD...
July 19, 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28722791/treatment-evaluation-using-lung-sound-analysis-in-asthmatic-children
#8
Chizu Habukawa, Katsumi Murakami, Mitsuru Endoh, Noriaki Horii, Yukio Nagasaka
BACKGROUND AND OBJECTIVE: Non-invasive assessment of treatment and prediction of attacks in asthmatic children do not yet exist. Lung sound analysis can non-invasively evaluate airway obstruction. We used a recently developed technology for analysing lung sounds using ic700 (index of the chest wall at 700 Hz, sound intensity at 700 Hz) to evaluate response to inhaled corticosteroid (ICS) in asthmatic children. METHOD: Seventy asthmatic children, including infants, underwent lung sound recording in the asymptomatic state prior to and 1, 2, 4, 6 and 8 weeks after ICS treatment, and asthma control was assessed at 10 weeks...
July 19, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28722667/assessment-of-anti-mda5-antibody-as-a-diagnostic-biomarker-in-patients-with-dermatomyositis-associated-interstitial-lung-disease-or-rapidly-progressive-interstitial-lung-disease
#9
Liubing Li, Qian Wang, Xiaoting Wen, Chenxi Liu, Chanyuan Wu, Funing Yang, Xiaofeng Zeng, Yongzhe Li
Anti-melanoma differentiation-associated protein 5 (MDA5) antibody have been found in dermatomyositis (DM)-associated interstitial lung disease (DM-ILD) and DM-associated rapidly progressive ILD (DM-RPILD). Due to the conflicting results regarding the association between anti-MDA5 antibody and DM-ILD or DM-RPILD and the diagnostic value of this antibody for DM-ILD and DM-RPILD, we performed this meta-analysis. A systematic search was performed to identify studies published to January 14, 2017. Sixteen publications with 491 DM with ILD versus 605 DM without ILD, as well as eighteen publications with 186 DM with RPILD and 790 DM without RPILD were included...
July 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28722663/systematic-review-and-meta-analysis-of-the-utility-of-long-non-coding-rna-gas5-as-a-diagnostic-and-prognostic-cancer-biomarker
#10
Wei Li, Na Li, Ke Shi, Qiong Chen
The growth arrest-specific 5 transcript (GAS5) is a long non-coding RNA (lncRNA) involved in the control of cell cycle progression and apoptosis in a wide variety of cells. To determine the clinical value of GAS5 expression in cancer patients, we performed a systematic review and meta-analysis exploring its association with the diagnosis, prognosis, and clinicopathological characteristics of cancer. Ten articles on prognosis, 15 on clinicopathology, and 5 on diagnosis were analyzed. Overall results showed that decreased GAS5 expression associated with unfavorable overall survival (OS) (HR = 2...
July 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28722317/reward-capacity-predicts-leptin-dynamics-during-laboratory-controlled-eating-in-women-as-a-function-of-body-mass-index
#11
Laura M Holsen, Benita Jackson
OBJECTIVE: The role of leptin in mesolimbic signaling of non-food-related rewards has been well established at the preclinical level, yet studies in humans are lacking. The present investigation explored the association between hedonic capacity and leptin dynamics and whether this association differed by BMI class. METHODS: In this cross-sectional study of 75 women (42 with BMIs in the lean range and 33 with BMIs in the obesity range), serum leptin before and after meal consumption was measured...
July 19, 2017: Obesity
https://www.readbyqxmd.com/read/28722298/development-of-a-bedside-viable-ultrasound-protocol-to-quantify-appendicular-lean-tissue-mass
#12
Michael T Paris, Benoit Lafleur, Joel A Dubin, Marina Mourtzakis
BACKGROUND: Ultrasound is a non-invasive and readily available tool that can be prospectively applied at the bedside to assess muscle mass in clinical settings. The four-site protocol, which images two anatomical sites on each quadriceps, may be a viable bedside method, but its ability to predict musculature has not been compared against whole-body reference methods. Our primary objectives were to (i) compare the four-site protocol's ability to predict appendicular lean tissue mass from dual-energy X-ray absorptiometry; (ii) optimize the predictability of the four-site protocol with additional anatomical muscle thicknesses and easily obtained covariates; and (iii) assess the ability of the optimized protocol to identify individuals with low lean tissue mass...
July 19, 2017: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/28722210/plasma-microrna-based-signatures-to-predict-3-year-postoperative-recurrence-risk-for-stage-ii-and-iii-gastric-cancer
#13
Xinyang Liu, Xiaowei Zhang, Zhe Zhang, Jinjia Chang, Zhichao Wang, Zheng Wu, Chenchen Wang, Zuojun Sun, Xiaoxiao Ge, Ruixuan Geng, Wenbo Tang, Congqi Dai, Ying Lin, Fengjuan Lin, Menghong Sun, Weihua Jia, Wenqiong Xue, Jiafu Ji, Ying Hu, Guoyou Qin, Jin Li
Our aim was to identify plasma microRNA (miRNA)-based signatures to predict 3-year postoperative recurrence risk for patients with stage II and III gastric cancer (GC) so as to provide insights for individualized adjuvant therapy. Plasma miRNA expression was investigated in three phases, involving 407 patients recruited from three centers. ABI miRNA microarray and TaqMan Low Density Array were adopted in the discovery phase to identify potential miRNAs. Quantitative reverse-transcriptase polymerase chain reaction was used to assess the expression of selected miRNAs...
July 19, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28722028/fat-free-mass-depletion-in-patients-with-copd-in-brazil-development-of-a-new-cutoff-point-and-its-relation-with-mortality-and-extrapulmonary-manifestations
#14
A Travassos, A Rodrigues, K C Furlanetto, L Donária, G W Bisca, A G Nellessen, F Pitta, N A Hernandes
BACKGROUND/OBJECTIVES: None of the cutoff points for fat-free mass index (FFMI) were tested for the Brazilian population, and it is unknown whether the available ones are able to discriminate extrapulmonary disease manifestations. This cross-sectional study aims to develop and validate a cutoff point for FFM depletion based on Brazilian patients with chronic obstructive pulmonary disease (COPD) and to verify its association and of previously published cutoffs with extrapulmonary manifestations...
July 19, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28721978/noninvasive-biomarkers-as-surrogate-predictors-of-clinical-and-endoscopic-remission-after-infliximab-induction-in-patients-with-refractory-ulcerative-colitis
#15
Elham A Hassan, Haidi K Ramadan, Ali A Ismael, Khaled F Mohamed, Madiha M El-Attar, Ihab Alhelali
BACKGROUND/AIMS: Treatment of refractory ulcerative colitis (UC) is a clinical challenge, and after biological therapy, monitoring clinical and endoscopic responses is fundamental. We aimed to investigate and compare the predictive power of different noninvasive parameters for clinical remission and mucosal healing after infliximab induction therapy in refractory UC patients. PATIENTS AND METHODS: Serum and fecal biomarkers, including hemoglobin, white blood cells, erythrocyte sedimentation rate, C-reactive protein (CRP), and fecal calprotectin (FC), and colonoscopy were assessed in 44 patients with refractory UC before and after (week 12) infliximab induction...
July 2017: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/28721884/dosimetric-predictors-of-patient-reported-xerostomia-and-dysphagia-with-deintensified-chemoradiation-therapy-for-hpv-associated-oropharyngeal-squamous-cell-carcinoma
#16
Bhishamjit S Chera, David Fried, Alex Price, Robert J Amdur, William Mendenhall, Chiray Lu, Shiva Das, Nathan Sheets, Lawrence Marks, Panayiotis Mavroidis
PURPOSE/OBJECTIVE(S): To estimate the association between different dose-volume metrics of the salivary glands and pharyngeal constrictors with patient reported severity of xerostomia/dysphagia in the setting of deintensified chemoradiation therapy (CRT). METHODS AND MATERIALS: Forty-five patients were treated on a phase 2 study assessing the efficacy of deintensified CRT for favorable-risk, HPV-associated oropharyngeal squamous cell carcinoma. Patients received 60 Gy intensity modulated radiation therapy with concurrent weekly cisplatin (30 mg/m(2)), and reported the severity of their xerostomia/dysphagia (before and after treatment) using the patient-reported outcome version of the Common Terminology Criteria for Adverse Events (CTCAE) (PRO-CTCAE)...
August 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28721696/usefulness-of-fragmented-qrs-in-hypertensive-patients-in-the-absence-of-left-ventricular-hypertrophy
#17
Mehmet Eyuboglu, Yavuz Karabag, Suleyman Karakoyun, Omer Senarslan, Zulkif Tanriverdi, Bahri Akdeniz
In the absence of left ventricular hypertrophy, importance of fragmented QRS complex (fQRS) in individuals with hypertension is unknown. The authors aimed to evaluate the relationship between blood pressure levels and fQRS in the absence of left ventricular hypertrophy. A total of 548 never-treated patients who underwent 24-hour ambulatory blood pressure monitoring were enrolled. The frequency of fQRS was significantly higher in patients with hypertension than normotension (36.4% vs 17.6%, P<.05). Multivariate logistic regression analysis revealed that systolic blood pressure is significantly associated with presence of fQRS on electrocardiography (odds ratio, 0...
July 18, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28721548/left-atrium-passive-ejection-fraction-is-the-most-sensitive-index-of-type-2-diabetes-mellitus-related-cardiac-changes
#18
Yongning Shang, Xiaochun Zhang, Weiling Leng, Xiaotian Lei, Liu Chen, Ziwen Liang, Jian Wang
The aims of this study were to use cardiovascular magnetic resonance (CMR) cine to assess left atrium (LA) and left ventricle (LV) function and structure in normotensive type 2 diabetes mellitus (T2DM) patients and to identify the most sensitive index of those T2DM-related cardiac changes. Fifty T2DM patients with normotension (25 males, age 54.7 ± 8.7 years, duration of diabetes: 7.5 ± 5.1 years) and 35 controls (16 males, age: 52.2 ± 13.2 years) were prospectively enrolled. All patients were scanned using CMR four- and two-chamber long-axis cine to assess LA and LV structure and function...
July 18, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28721500/early-prediction-of-tumor-response-to-bevacizumab-treatment-in-murine-colon-cancer-models-using-three-dimensional-dynamic-contrast-enhanced-ultrasound-imaging
#19
Jianhua Zhou, Huiping Zhang, Huaijun Wang, Amelie M Lutz, Ahmed El Kaffas, Lu Tian, Dimitre Hristov, Jürgen K Willmann
Due to spatial tumor heterogeneity and consecutive sampling errors, it is critically important to assess treatment response following antiangiogenic therapy in three dimensions as two-dimensional assessment has been shown to substantially over- and underestimate treatment response. In this study, we evaluated whether three-dimensional (3D) dynamic contrast-enhanced ultrasound (DCE-US) imaging allows assessing early changes in tumor perfusion following antiangiogenic treatment (bevacizumab administered at a dose of 10 mg/kg b...
July 18, 2017: Angiogenesis
https://www.readbyqxmd.com/read/28721478/differentiation-of-renal-cell-carcinoma-subtypes-with-different-iodine-quantification-methods-using-single-phase-contrast-enhanced-dual-energy-ct-areal-vs-volumetric-analyses
#20
Chenchen Dai, Yingli Cao, Yan Jia, Yuqin Ding, Ruofan Sheng, Mengsu Zeng, Jianjun Zhou
PURPOSE: To investigate the possibility of iodine quantification during a single nephrographic phase in characterizing renal cell carcinoma (RCC) subtypes and if there is a difference between areal and volumetric iodine quantification methods. MATERIALS AND METHODS: This retrospective study included 110 patients with 113 histopathologically confirmed RCCs scanned by dual-energy CT at the nephrographic phase before surgeries. For each lesion, an areal measurement of the iodine concentration with maximum enhancement (I max enhan) and the iodine concentration with maximum area among slices (I max area), as well as a volumetric iodine concentration of the whole-tumor (I volume), were evaluated by two independent radiologists...
July 18, 2017: Abdominal Radiology
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