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https://www.readbyqxmd.com/read/28099485/cell-based-systems-biology-analysis-of-human-as03-adjuvanted-h5n1-avian-influenza-vaccine-responses-a-phase-i-randomized-controlled-trial
#1
Leigh M Howard, Kristen L Hoek, Johannes B Goll, Parimal Samir, Allison Galassie, Tara M Allos, Xinnan Niu, Laura E Gordy, C Buddy Creech, Nripesh Prasad, Travis L Jensen, Heather Hill, Shawn E Levy, Sebastian Joyce, Andrew J Link, Kathryn M Edwards
BACKGROUND: Vaccine development for influenza A/H5N1 is an important public health priority, but H5N1 vaccines are less immunogenic than seasonal influenza vaccines. Adjuvant System 03 (AS03) markedly enhances immune responses to H5N1 vaccine antigens, but the underlying molecular mechanisms are incompletely understood. OBJECTIVE AND METHODS: We compared the safety (primary endpoint), immunogenicity (secondary), gene expression (tertiary) and cytokine responses (exploratory) between AS03-adjuvanted and unadjuvanted inactivated split-virus H5N1 influenza vaccines...
2017: PloS One
https://www.readbyqxmd.com/read/28093379/the-epital-care-model-a-new-person-centered-model-of-technology-enabled-integrated-care-for-people-with-long-term-conditions
#2
Klaus Phanareth, Søren Vingtoft, Anders Skovbo Christensen, Jakob Sylvest Nielsen, Jørgen Svenstrup, Gro Karine Rosvold Berntsen, Stanton Peter Newman, Lars Kayser
BACKGROUND: There is worldwide recognition that the future provision of health care requires a reorganization of provision of care, with increased empowerment and engagement of patients, along with skilled health professionals delivering services that are coordinated across sectors and organizations that provide health care. Technology may be a way to enable the creation of a coherent, cocreative, person-centered method to provide health care for individuals with one or more long-term conditions (LTCs)...
January 16, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28091333/an-ecological-approach-to-reducing-potentially-inappropriate-medication-use-canadian-deprescribing-network
#3
Cara Tannenbaum, Barbara Farrell, James Shaw, Steve Morgan, Johanna Trimble, Jane Currie, Justin Turner, Paula Rochon, James Silvius
Polypharmacy is growing in Canada, along with adverse drug events and drug-related costs. Part of the solution may be deprescribing, the planned and supervised process of dose reduction or stopping of medications that may be causing harm or are no longer providing benefit. Deprescribing can be a complex process, involving the intersection of patients, health care providers, and organizational and policy factors serving as enablers or barriers. This article describes the justification, theoretical foundation, and process for developing a Canadian Deprescribing Network (CaDeN), a network of individuals, organizations, and decision-makers committed to promoting the appropriate use of medications and non-pharmacological approaches to care, especially among older people in Canada...
January 16, 2017: Canadian Journal on Aging, la Revue Canadienne du Vieillissement
https://www.readbyqxmd.com/read/28086976/impact-of-a-tailored-program-on-the-implementation-of-evidence-based-recommendations-for-multimorbid-patients-with-polypharmacy-in-primary-care-practices-results-of-a-cluster-randomized-controlled-trial
#4
Cornelia Jäger, Tobias Freund, Jost Steinhäuser, Christian Stock, Johannes Krisam, Petra Kaufmann-Kolle, Michel Wensing, Joachim Szecsenyi
BACKGROUND: Multimorbid patients receiving polypharmacy represent a growing population at high risk for negative health outcomes. Tailoring is an approach of systematic intervention development taking account of previously identified determinants of practice. The aim of this study was to assess the effect of a tailored program to improve the implementation of three important processes of care for this patient group: (a) structured medication counseling including brown bag reviews, (b) the use of medication lists, and (c) structured medication reviews to reduce potentially inappropriate medication...
January 13, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/28065543/mitigating-dietary-arsenic-exposure-current-status-in-the-united-states-and-recommendations-for-an-improved-path-forward
#5
Keeve E Nachman, Gary L Ginsberg, Mark D Miller, Carolyn J Murray, Anne E Nigra, Claire B Pendergrast
Inorganic arsenic (iAs) is a well-characterized carcinogen, and recent epidemiologic studies have linked chronic exposures to non-cancer health outcomes, including cardiovascular disease, diabetes, skin lesions and respiratory disorders. Greater vulnerability has been demonstrated with early life exposure for health effects including lung and bladder cancer, immunotoxicity and neurodevelopment. Despite its well-known toxicity, there are important gaps in the regulatory oversight of iAs in food and in risk communication...
January 5, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28056926/edible-bird-s-nest-modulate-intracellular-molecular-pathways-of-influenza-a-virus-infected-cells
#6
Amin Haghani, Parvaneh Mehrbod, Nikoo Safi, Fadzilah A'ini Abd Kadir, Abdul Rahman Omar, Aini Ideris
BACKGROUND: Edible Bird's Nest (EBN) as a popular traditional Chinese medicine is believed to have health enhancing and antiviral activities against influenza A virus (IAV); however, the molecular mechanism behind therapeutic effects of EBN is not well characterized. METHODS: In this study, EBNs that underwent different enzymatic preparation were tested against IAV infected cells. 50% cytotoxic concentration (CC50) and 50% inhibitory concentration (IC50) of the EBNs against IAV strain A/Puerto Rico/8/1934(H1N1) were determined by HA and MTT assays...
January 5, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28051972/characteristics-classification-and-prevention-of-child-maltreatment-fatalities
#7
James E McCarroll, Joscelyn E Fisher, Stephen J Cozza, Renè J Robichaux, Carol S Fullerton
BACKGROUND: Preventing child maltreatment fatalities is a critical goal of the U.S. society and the military services. Fatality review boards further this goal through the analysis of circumstances of child deaths, making recommendations for improvements in practices and policies, and promoting increased cooperation among the many systems that serve families. The purpose of this article is to review types of child maltreatment death, proposed classification models, risk and protective factors, and prevention strategies...
January 2017: Military Medicine
https://www.readbyqxmd.com/read/28051827/job-stress-an-in-depth-investigation-based-on-the-hse-questionnaire-and-a-multistep-approach-in-order-to-identify-the-most-appropriate-corrective-actions
#8
S De Sio, F Cedrone, E Greco, M Di Traglia, D Sanità, D Mandolesi, S A Stansfeld
BACKGROUND: Psychosocial hazards and work-related stress have reached epidemic proportions in Europe. The Italia law introduced in 2008 the obligation for Italian companies to assess work related stress risk in order to protect their workers' safety and health. The purpose of our study was to propose an accurate measurement tool, using the HSE indicator tool, for more appropriate and significant work-related stress' prevention measures. METHODS: The study was conducted on 204 visual display unit (VDU) operators: 106 male and 98 female...
November 2016: La Clinica Terapeutica
https://www.readbyqxmd.com/read/28050422/yoga-practice-for-reducing-the-male-obesity-and-weight-related-psychological-difficulties-a-randomized-controlled-trial
#9
P B Rshikesan, Pailoor Subramanya, Ram Nidhi
INTRODUCTION: Obesity is a health disorder and increasing all over the world. It is also a cause for many non-communicable diseases. Yoga practice reduces the stress level which may improve the eating habits and help in weight reduction. AIM: To assess the final outcome of the effects after 3 months of the 14 weeks yoga training on obesity of adult male in an urban setting. MATERIALS AND METHODS: This was a randomized controlled trial with parallel groups (Yoga and Control groups) on male obese...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28049472/implementation-of-a-recovery-oriented-model-in-a-sub-acute-intermediate-stay-mental-health-unit-ismhu
#10
Barry G Frost, Megan Turrell, Ketrina A Sly, Terry J Lewin, Agatha M Conrad, Suzanne Johnston, Srinivasan Tirupati, Kerry Petrovic, Sadanand Rajkumar
BACKGROUND: An ongoing service evaluation project was initiated following the establishment of a new, purpose-built, 20-bed sub-acute Intermediate Stay Mental Health Unit (ISMHU). This paper: provides an overview of the targeted 6-week program, operating within an Integrated Recovery-oriented Model (IRM); characterises the clients admitted during the first 16 months; and documents their recovery needs and any changes. METHODS: A brief description of the unit's establishment and programs is initially provided...
January 3, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28049344/changes-in-physical-activity-among-coronary-and-hypertensive-patients-a-longitudinal-study-using-the-health-action-process-approach
#11
P Steca, L Pancani, F Cesana, F Fattirolli, C Giannattasio, A Greco, M D'Addario, D Monzani, E R Cappelletti, M E Magrin, M Miglioretti, M Sarini, M Scrignaro, L Vecchio, C Franzelli
OBJECTIVES: Physical activity (PA) is a key factor in cardiovascular disease prevention. Through the Health Action Process Approach (HAPA), the present study investigated the process of change in PA in coronary patients (CPs) and hypertensive patients (HPs). DESIGN: Longitudinal survey study with two follow-up assessments at 6 and 12 months on 188 CPs and 169 HPs. MAIN OUTCOME MEASURES: Intensity and frequency of PA. RESULTS: A multi-sample analysis indicated the equivalence of almost all the HAPA social cognitive patterns for both patient populations...
January 4, 2017: Psychology & Health
https://www.readbyqxmd.com/read/28045940/applying-the-integrated-practice-unit-concept-to-a-modified-virtual-ward-model-of-care-for-patients-at-highest-risk-of-readmission-a-randomized-controlled-trial
#12
Lian Leng Low, Shu Yun Tan, Matthew Joo Ming Ng, Wei Yi Tay, Lee Beng Ng, Kanchana Balasubramaniam, Rachel Marie Towle, Kheng Hock Lee
BACKGROUND: Emerging evidence from the virtual ward care model showed that multidisciplinary case management are inadequate to reduce readmissions or death for high risk patients. There is consensus that interventions should encompass both pre-hospital discharge and post-discharge transitional care to be effective. Integrated practice units (IPU) had been proposed as an approach of restructuring the organization and work processes of multidisciplinary teams to achieve value in healthcare...
2017: PloS One
https://www.readbyqxmd.com/read/28034720/qualitative-development-of-a-discrete-choice-experiment-for-physical-activity-interventions-to-improve-knee-osteoarthritis
#13
Daniel Pinto, Margaret Danilovich, Paul Hansen, Daniel J Finn, Rowland W Chang, Jane L Holl, Allen W Heinemann, Ulf Bockenholt
OBJECTIVE: To describe the qualitative process used to develop attributes and attribute levels for inclusion in a discrete choice experiments (DCE) for older adult physical activity interventions. DESIGN: Five focus groups (a total of 41 participants) were conducted, grounded in the Health Action Process Approach framework. Discussion emphasized identification and prioritization attributes for a DCE on physical activity. Semi-structured interviews (n=6) investigated attribute levels and lay-language for the DCE...
December 27, 2016: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28025810/application-of-a-combined-approach-to-identify-new-psychoactive-street-drugs-and-decipher-their-mechanisms-at-monoamine-transporters
#14
Felix P Mayer, Anton Luf, Constanze Nagy, Marion Holy, Rainer Schmid, Michael Freissmuth, Harald H Sitte
Psychoactive compounds can cause acute and long-term health problems and lead to addiction. In addition to well-studied and legally controlled compounds like cocaine, new psychoactive substances (NPS) are appearing in street drug markets as replacement strategies and legal alternatives. NPS are effectively marketed as "designer drugs" or "research chemicals" without any knowledge of their underlying pharmacological mode of action and their potential toxicological effects and obviously devoid of any registration process...
December 27, 2016: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/28011657/citizen-science-for-public-health
#15
Lea Den Broeder, Jeroen Devilee, Hans Van Oers, A Jantine Schuit, Annemarie Wagemakers
Community engagement in public health policy is easier said than done. One reason is that public health policy is produced in a complex process resulting in policies that may appear not to link up to citizen perspectives. We therefore address the central question as to whether citizen engagement in knowledge production could enable inclusive health policy making. Building on non-health work fields, we describe different types of citizen engagement in scientific research, or 'Citizen Science'. We describe the challenges that Citizen Science poses for public health, and how these could be addressed...
December 23, 2016: Health Promotion International
https://www.readbyqxmd.com/read/28006739/participatory-action-inquiry-using-baccalaureate-nursing-students-the-inclusion-of-integrative-health-care-modalities-in-nursing-core-curriculum
#16
Roxane Raffin Chan, Michelle Schaffrath
Nurses, nursing educators and students support the inclusion of integrative health care (IHC) into nursing core curriculum as a way to create nurses who deliver nursing care to the full extent of their scope of practice and advance evidenced based IHC. Because of the holistic nature of IHC modalities, research to investigate appropriate teaching strategies and potential efficacy of learning IHC in the baccalaureate core curriculum requires a holistic approach. Therefore a phenomenological exploration using participatory action inquiry was conducted at a large Midwestern university...
December 9, 2016: Nurse Education in Practice
https://www.readbyqxmd.com/read/28000373/the-care-network-of-the-families-involved-in-family-violence-against-children-and-adolescents-the-primary-health-care-perspective
#17
Diene Monique Carlos, Elisabete Matallo Marchesini de Pádua, Lygia Maria Pereira da Silva, Marta Angélica Iossi Silva, Walter Ernesto Ude Marques, Maria Neto da Cruz Leitão, Maria das Graças Carvalho Ferriani
AIMS AND OBJECTIVES: Contribute to the understanding of the network care provided to families involved in family violence against children and adolescents (FVACA), from the Primary Health Care (PHC) perspective. BACKGROUND: Children and adolescents figure among the main victims of violence around the world, which occurs predominantly in the family context. PHC-guided network care has emerged as a new process that contrasts with traditional approaches, which rely on fragmented, punctual, and compensatory actions and produce simplified and segmented interventions in response to complex phenomena like violence...
December 21, 2016: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/27999272/sustainable-lifestyle-change-participatory-design-of-support-together-with-persons-with-obesity-in-the-third-age
#18
Sarianne Wiklund Axelsson, Åsa Wikberg-Nilsson, Anita Melander Wikman
Sustainable lifestyle changes due to obesity are difficult to achieve regardless methods used. We need to know more about the lived experience of obesity and older persons' needs for support to make a sustainable change. This paper focuses on the need-finding process in designing support for a sustainable lifestyle change. Multistage focus group interviews were conducted with persons aged 61-72 living in Northern Sweden. A participatory and appreciative reflection and action (PAAR) approach was used in the group-sessions...
December 16, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27998744/modern-perspectives-of-measurement-validation-emphasize-justification-of-inferences-based-on-patient-reported-outcome-scores
#19
Richard Sawatzky, Eric K H Chan, Bruno D Zumbo, Sara Ahmed, Susan Bartlett, Clifton O Bingham, William Gardner, Jeffrey Jutai, Ayse Kuspinar, Tolulope Sajobi, Lisa M Lix
BACKGROUND: Obtaining the patient's view about the outcome of care is an essential component of patient-centred care. Many patient-reported outcome (PRO) instruments for different purposes have been developed since the 1960s. Measurement validation is fundamental in the development, evaluation, and use of PRO instruments. OBJECTIVE: This paper provides a review of modern perspectives of measurement validation in relation to the followings three questions as applied to PROs: 1) What evidence is needed to warrant comparisons between groups and individuals? 2) What evidence is needed to warrant comparisons over time? 3) What are the value implications, including personal and societal consequences, of using PRO scores? DISCUSSION: Measurement validation is an ongoing process that involves the accumulation of evidence regarding the justification of inferences, actions and decisions based on measurement scores...
December 17, 2016: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/27997259/a-new-comprehensive-model-for-continuous-professional-development
#20
Niels Kristian Kjaer, Marianne Vedsted, James Høpner
BACKGROUND: It is generally agreed that continuing professional development (CPD) for GPs is important for quality of care. Internationally, however, different approaches to identify the learning objectives and the CPD content have been chosen. OBJECTIVES: To improve GPs' CPD in Denmark we explore how general practitioners' (GPs) self-experienced learning needs can be combined with learning needs experienced from a societal perspective and still make sense for GPs...
December 20, 2016: European Journal of General Practice
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