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MicroRNA nutrition

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https://www.readbyqxmd.com/read/29732466/novel-insights-into-the-regulation-of-mirna-transcriptional-control-implications-for-t2d-and-related-complications
#1
Lucia La Sala, Stefano Micheloni, Valeria De Nigris, Francesco Prattichizzo, Antonio Ceriello
In recent years, epigenetics has emerged as an important form of biological regulation involving chromatin control of gene expression. The mechanisms of this fine-tuned regulation are susceptible to changes forced by environmental stimuli and nutritional factors and may be potentially reversible. Dysregulation of epigenetic processes has important consequences for the pathogenesis of complex and multifactorial diseases such as type 2 diabetes (T2D) and vascular complications. Along with DNA methylation (DNA-me), histone modifications and RNA-based mechanisms as the major epigenetic controllers, small non-coding RNAs known as microRNAs (miRNAs) have their own important implications for the pathogenesis of diabetes...
May 7, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29656008/identification-of-mirnas-linked-with-the-drought-response-of-tef-eragrostis-tef-zucc-trotter
#2
Federico Martinelli, Gina Cannarozzi, Bipin Balan, Fredy Siegrist, Annett Weichert, Regula Blösch, Zerihun Tadele
Tef [Eragrostis tef (Zucc.) Trotter], a staple food crop in the Horn of Africa and particularly in Ethiopia, has several beneficial agronomical and nutritional properties, including waterlogging and drought tolerance. In this study, we performed microRNA profiling of tef using the Illumina HiSeq 2500 platform, analyzing both shoots and roots of two tef genotypes, one drought-tolerant (Tsedey) and one drought-susceptible (Alba). We obtained more than 10 million filtered reads for each of the 24 sequenced small cDNA libraries...
March 29, 2018: Journal of Plant Physiology
https://www.readbyqxmd.com/read/29627443/breast-milk-micrornas-harsh-journey-towards-potential-effects-in-infant-development-and-maturation-lipid-encapsulation-can-help
#3
REVIEW
João Tomé-Carneiro, Noelia Fernández-Alonso, Cristina Tomás-Zapico, Francesco Visioli, Eduardo Iglesias-Gutierrez, Alberto Dávalos
The possibility that diet-derived miRNAs survive the gastrointestinal tract and exert biological effects in target cells is triggering considerable research in the potential abilities of alimentary preventive and therapeutic approaches. Many validation attempts have been carried out and investigators disagree on several issues. The barriers exogenous RNAs must surpass are harsh and adequate copies must reach target cells for biological actions to be carried out. This prospect opened a window for previously unlikely scenarios concerning exogenous non-coding RNAs, such as a potential role for breast milk microRNAs in infants' development and maturation...
April 5, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29605533/a-comparative-analysis-of-corpora-allata-corpora-cardiaca-microrna-repertories-revealed-significant-changes-during-mosquito-metamorphosis
#4
Marcela Nouzova, Kayvan Etebari, Fernando G Noriega, Sassan Asgari
The corpora allata (CA) are a pair of endocrine glands with neural connections to the brain and close association with another neuroendocrine organ, the corpora cardiaca (CC). The CA from adult female Aedes aegypti mosquitoes synthesizes fluctuating levels of juvenile hormone (JH), which have been linked to the ovarian development and are influenced by nutritional signals. In this study, we investigated the potential involvement of microRNAs (miRNAs), a type of small non-coding RNAs, in the regulation of gene expression in CA-CC complexes during mosquito reproductive development, at stages with distinct JH biosynthesis patterns...
March 29, 2018: Insect Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29588175/identification-and-analysis-of-micrornas-mrnas-pairs-associated-with-nutritional-status-in-seasonal-sheep
#5
Heng Yang, Xianxia Liu, Guangdong Hu, Yifan Xie, Shan Lin, Zongsheng Zhao, Jingbo Chen
Given the important role of nutritional status for reproductive performance, we aimed to explore the potential microRNA (miRNA)-mRNA pairs and their regulatory roles associated with nutritional status in seasonal reproducing sheep. Individual ewes were treated with and without 0.3 kg/day concentrates, and the body condition score, estrus rate, and related miRNAs and target genes were compared. A total of 261 differentially expressed miRNAs were identified, including 148 hypothalamus-expressed miRNAs and 113 ovary-expressed miRNAs, and 349 target genes were predicted to be associated with nutritional status and seasonal reproduction in sheep...
March 24, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29554761/engineered-nanomaterials-for-plant-growth-and-development-a-perspective-analysis
#6
REVIEW
Sandeep Kumar Verma, Ashok Kumar Das, Manoj Kumar Patel, Ashish Shah, Vinay Kumar, Saikat Gantait
With the overwhelmingly rapid advancement in the field of nanotechnology, the engineered nanomaterials (ENMs) have been extensively used in various areas of the plant system, including quality improvement, growth and nutritional value enhancement, gene preservation etc. There are several recent reports on the ENMs' influence on growth enhancements, growth inhibition as well as certain toxic impacts on plant. However, translocation, growth responses and stress modulation mechanisms of ENMs in the plant systems call for better and in-depth understanding...
March 3, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29511965/exercise-and-weight-loss-interventions-and-mirna-expression-in-women-with-breast-cancer
#7
Brian D Adams, Hannah Arem, Monica J Hubal, Brenda Cartmel, Fangyong Li, Maura Harrigan, Tara Sanft, Christopher J Cheng, Lajos Pusztai, Melinda L Irwin
PURPOSE: Obesity and weight gain are associated with comorbidities including a higher risk of tumor recurrence and cancer-related deaths among breast cancer (BC) survivors; however, the underlying mechanisms linking obesity and cancer are poorly understood. Given the lack of clinically validated BC biomarkers, obesity and weight-loss studies utilize serum biomarkers as the intermediary outcomes of tumor recurrence. Studies have indicated microRNAs (miRNA)s are reliable biomarkers for cancer...
March 6, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29507325/identification-of-micrornas-involved-in-lipid-biosynthesis-and-seed-size-in-developing-sea-buckthorn-seeds-using-high-throughput-sequencing
#8
Jian Ding, Chengjiang Ruan, Ying Guan, Priti Krishna
Sea buckthorn is a plant of medicinal and nutritional importance owing in part to the high levels of essential fatty acids, linoleic (up to 42%) and α-linolenic (up to 39%) acids in the seed oil. Sea buckthorn can produce seeds either via the sexual pathway or by apomixis. The seed development and maturation programs are critically dependent on miRNAs. To understand miRNA-mediated regulation of sea buckthorn seed development, eight small RNA libraries were constructed for deep sequencing from developing seeds of a low oil content line 'SJ1' and a high oil content line 'XE3'...
March 5, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29446655/micrornas-as-molecular-targets-of-quercetin-and-its-derivatives-underlying-their-biological-effects-a-preclinical-strategy
#9
Dan Wang, Dongxiao Sun-Waterhouse, Feng Li, Li Xin, Dapeng Li
Quercetin is a well-known flavonoid naturally occurring in most of the plant foods and is often found in the human diet. It can act as a potent antioxidant and anti-inflammatory agent, and plays significant roles in the prevention of various chronic diseases. Recent findings revealed that quercetin could affect metabolic traits by regulating certain transcription factors or key proteins involved in cellular signal pathways and influencing the expression of functional genes along with related regulatory pathway(s), and that microRNAs (miRNAs) circulate in body fluids and are involved in post-transcriptional gene silencing and regulation of gene expression in various biological processes including development, proliferation, metabolism and inflammation...
February 15, 2018: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29428334/biotechnology-challenges-to-in-vitro-maturation-of-hepatic-stem-cells
#10
REVIEW
Chen Chen, Alejandro Soto-Gutierrez, Pedro M Baptista, Bart Spee
The incidence of liver disease is increasing globally. The only curative therapy for severe end-stage liver disease, liver transplantation, is limited by the shortage of organ donors. In vitro models of liver physiology have been developed and new technologies and approaches are progressing rapidly. Stem cells might be used as a source of liver tissue for development of models, therapies, and tissue-engineering applications. However, we have been unable to generate and maintain stable and mature adult liver cells ex vivo...
April 2018: Gastroenterology
https://www.readbyqxmd.com/read/29420841/daphnia-magna-micrornas-respond-to-nutritional-stress-and-ageing-but-are-not-transgenerational
#11
Jack Hearn, Franklin Wang-Ngai Chow, Harriet Barton, Matthew Tung, Philip J Wilson, Mark Blaxter, Amy Buck, Tom J Little
Maternal effects, where the performance of offspring is determined by the condition of their mother, are widespread and may in some cases be adaptive. The crustacean Daphnia magna shows strong maternal effects: offspring size at birth and other proxies for fitness are altered when their mothers are older or when mothers have experienced dietary restriction. The mechanisms for this transgenerational transmission of maternal experience are unknown, but could include changes in epigenetic patterning. MicroRNAs (miRNAs) are regulators of gene expression that have been shown to play roles in intergenerational information transfer, and here, we test whether miRNAs are involved in D...
March 2018: Molecular Ecology
https://www.readbyqxmd.com/read/29415651/integrative-analysis-of-micrornas-and-mrnas-revealed-regulation-of-composition-and-metabolism-in-nelore-cattle
#12
Gabriella B Oliveira, Luciana C A Regitano, Aline S M Cesar, James M Reecy, Karina Y Degaki, Mirele D Poleti, Andrezza M Felício, James E Koltes, Luiz L Coutinho
BACKGROUND: The amount of intramuscular fat can influence the sensory characteristics and nutritional value of beef, thus the selection of animals with adequate fat deposition is important to the consumer. There is growing knowledge about the genes and pathways that control the biological processes involved in fat deposition in muscle. MicroRNAs (miRNAs) belong to a well-conserved class of non-coding small RNAs that modulate gene expression across a range of biological functions in animal development and physiology...
February 7, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29366447/nutritional-status-affects-the-microrna-profile-of-the-hypothalamus-of-female-sheep
#13
Heng Yang, Shan Lin, Xiaoping Lei, Cong Yuan, Yaosheng Yu, Zongsheng Zhao, Jingbo Chen
Recent studies on the seasonal regulation of the oestrous cycle in sheep have focussed mainly on the responses to photoperiod. However, the brain systems that control reproductive activity also respond to nutritional inputs, although the molecular mechanisms involved are not completely understood. One possibility is that small, non-coding RNAs, such as micro-RNAs (miRNAs), have significant influence. In the present study, the amounts and characteristics of miRNAs in hypothalamus from oestrous and anestrous ewes, fed low- or high-nutrient diets, were compared using Illumina HiSeq sequencing technology...
January 25, 2018: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/29364022/micromanaging-the-gut-unravelling-the-regulatory-pathways-that-mediate-the-intestinal-adaptive-response
#14
A Balakrishnan
Short bowel syndrome occurs following the loss of a large portion of functional intestine and is associated with high morbidity and mortality. The intestine exhibits pronounced diurnal rhythms in glucose absorption and mounts a profound proliferative response following massive small bowel resection. Understanding the molecular pathways that underpin this could yield novel treatment options. Two in vivo models were employed using the nocturnally active Sprague Dawley® rat, namely daytime feeding and massive small bowel resection...
March 2018: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/29295476/detection-of-plant-mirnas-abundance-in-human-breast-milk
#15
Anna Lukasik, Iwona Brzozowska, Urszula Zielenkiewicz, Piotr Zielenkiewicz
Breast milk is a natural food and important component of infant nutrition. Apart from the alimentary substances, breast milk contains many important bioactive compounds, including endogenous microRNA molecules (miRNAs). These regulatory molecules were identified in various mammalian biological fluids and were shown to be mostly packed in exosomes. Recently, it was revealed that plant food-derived miRNAs are stably present in human blood and regulate the expression of specific human genes. Since then, the scientific community has focused its efforts on contradicting or confirming this discovery...
December 23, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29278767/mir-183-regulates-milk-fat-metabolism-via-mst1-in-goat-mammary-epithelial-cells
#16
Zhi Chen, HuaiPing Shi, Shuang Sun, Jun Luo, Wei Zhang, Yu Hou, Juan J Loor
The nutritional value of goat milk largely depends on its fatty acid content and composition. MicroRNAs (miRNAs) are a class of RNA molecules 18-25nt in length that regulate gene expression and play crucial roles in several biological processes, including fatty acid metabolism. In this study, we analyzed the correlation between differentially expressed miRNAs in goat mammary tissue and the fatty acid composition of goat milk by using Pearson correlations. Results revealed that levels of miR-183 were highly and positively correlated with the fatty acid content in the milk...
March 10, 2018: Gene
https://www.readbyqxmd.com/read/29248758/poor-cognitive-ageing-vulnerabilities-mechanisms-and-the-impact-of-nutritional-interventions
#17
REVIEW
Sophie Miquel, Claire Champ, Jon Day, Esther Aarts, Ben A Bahr, Martijntje Bakker, Diána Bánáti, Vittorio Calabrese, Tommy Cederholm, John Cryan, Louise Dye, Jonathan A Farrimond, Aniko Korosi, Sophie Layé, Stuart Maudsley, Dragan Milenkovic, M Hasan Mohajeri, John Sijben, Alina Solomon, Jeremy P E Spencer, Sandrine Thuret, Wim Vanden Berghe, David Vauzour, Bruno Vellas, Keith Wesnes, Peter Willatts, Raphael Wittenberg, Lucie Geurts
BACKGROUND: Ageing is a highly complex process marked by a temporal cascade of events, which promote alterations in the normal functioning of an individual organism. The triggers of normal brain ageing are not well understood, even less so the factors which initiate and steer the neuronal degeneration, which underpin disorders such as dementia. A wealth of data on how nutrients and diets may support cognitive function and preserve brain health are available, yet the molecular mechanisms underlying their biological action in both normal ageing, age-related cognitive decline, and in the development of neurodegenerative disorders have not been clearly elucidated...
March 2018: Ageing Research Reviews
https://www.readbyqxmd.com/read/29197334/identification-and-characterization-of-prunus-persica-mirnas-in-response-to-uvb-radiation-in-greenhouse-through-high-throughput-sequencing
#18
Shaoxuan Li, Zhanru Shao, Xiling Fu, Wei Xiao, Ling Li, Ming Chen, Mingyue Sun, Dongmei Li, Dongsheng Gao
BACKGROUND: MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression of target mRNAs involved in plant growth, development, and abiotic stress. As one of the most important model plants, peach (Prunus persica) has high agricultural significance and nutritional values. It is well adapted to be cultivated in greenhouse in which some auxiliary conditions like temperature, humidity, and UVB etc. are needed to ensure the fruit quality. However, little is known about the genomic information of P...
December 2, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29170059/the-clinical-potential-of-adipogenesis-and-obesity-related-micrornas
#19
REVIEW
M Zaiou, H El Amri, A Bakillah
Obesity is a growing health problem commonly associated with numerous metabolic disorders including type 2 diabetes, hypertension, cardiovascular disease, and some forms of cancer. The burden of obesity and associated cardiometabolic diseases are believed to arise through complex interplay between genetics and epigenetics predisposition, nutrition, environment, and lifestyle. However, the molecular basis and the repertoire of obesity-affecting factors are still unknown. Emerging evidence is connecting microRNAs (miRNAs) dysregulation with adipogenesis and obesity...
February 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29154903/in-vitro-mesenchymal-epithelial-transition-in-nih3t3-fibroblasts-results-in-onset-of-low-dose-radiation-hypersensitivity-coupled-with-attenuated-connexin-43-response
#20
Ankit Mathur, Ashish Kumar, Bincy Babu, Sudhir Chandna
BACKGROUND: Mesenchymal-to-epithelial transition (MET) is associated with altered cell adhesion patterns. Independent studies showed that cellular adhesion regulates low-dose hyper-radiosensitivity (HRS), a phenomenon reported widely in tumour cells. Therefore, present study aimed to investigate whether MET and associated cellular adhesion alterations affect cellular radiosensitivity. METHODS: We established multiple stages of MET by in vitro transformation of NIH3T3 mouse embryonic fibroblasts...
March 2018: Biochimica et Biophysica Acta
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