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https://www.readbyqxmd.com/read/27767010/transmission-of-babesia-microti-parasites-by-solid-organ-transplantation
#1
Meghan B Brennan, Barbara L Herwaldt, James J Kazmierczak, John W Weiss, Christina L Klein, Catherine P Leith, Rong He, Matthew J Oberley, Laura Tonnetti, Patricia P Wilkins, Gregory M Gauthier
Babesia microti, an intraerythrocytic parasite, is tickborne in nature. In contrast to transmission by blood transfusion, which has been well documented, transmission associated with solid organ transplantation has not been reported. We describe parasitologically confirmed cases of babesiosis diagnosed ≈8 weeks posttransplantation in 2 recipients of renal allografts from an organ donor who was multiply transfused on the day he died from traumatic injuries. The organ donor and recipients had no identified risk factors for tickborne infection...
November 2016: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/27760547/secondary-bladder-amyloidosis-with-familial-mediterranean-fever-in-a-living-donor-kidney-transplant-recipient-a-case-report
#2
Sentaro Imamura, Shintaro Narita, Ryuta Nishikomori, Hiroshi Tsuruta, Kazuyuki Numakura, Atsushi Maeno, Mitsuru Saito, Takamitsu Inoue, Norihiko Tsuchiya, Hiroshi Nanjo, Toshio Heike, Shigeru Satoh, Tomonori Habuchi
BACKGROUND: Secondary bladder amyloidosis is an extremely rare disease, resulting from a chronic systematic inflammatory disorder associated with amyloid deposits. Although uncommon in Japan, familial Mediterranean fever (FMF) is a hereditary autoinflammatory disease characterized by recurrent episodes of fever of short duration and serositis and is frequently associated with systemic amyloidosis. Here, we present a case of a Japanese patient complaining of fever and macroscopic hematuria after a living donor renal transplantation...
October 19, 2016: BMC Research Notes
https://www.readbyqxmd.com/read/27666815/role-of-galectin-3-in-autoimmune-and-non-autoimmune-nephropathies
#3
Francesca Saccon, Mariele Gatto, Anna Ghirardello, Luca Iaccarino, Leonardo Punzi, Andrea Doria
Galectins are evolutionary conserved β-galactoside binding proteins with a carbohydrate-recognition domain (CRD) of approximately 130 amino acids. In mammals, 15 members of the galectin family have been identified and classified into three subtypes according to CRD organization: prototype, tandem repeat-type and chimera-type galectins. Galectin-3 (gal-3) is the only chimera type galectin in vertebrates containing one CRD linked to an unusual long N-terminal domain which displays non-lectin dependent activities...
September 23, 2016: Autoimmunity Reviews
https://www.readbyqxmd.com/read/27405040/the-uptake-of-18f-fdg-by-renal-allograft-in-kidney-transplant-recipients-is-not-influenced-by-renal-function
#4
Alexandre Jadoul, Pierre Lovinfosse, Laurent Weekers, Pierre Delanaye, Jean-Marie Krzesinski, Roland Hustinx, François Jouret
PURPOSE OF THE REPORT: F-FDG PET/CT has been recently proposed as a noninvasive tool for the diagnosis of renal allograft acute rejection (AR) in kidney transplant recipients (KTRs). Still, the influence of kidney function on F-FDG uptake by renal grafts remains unknown. PATIENTS AND METHODS: We retrospectively identified all KTRs who underwent at least one F-FDG PET/CT. Kidney transplant recipients with documented pyelonephritis or AR were excluded. Estimated glomerular filtration rate (eGFR) was assessed using chronic kidney disease (CKD)-EPI equation...
September 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27194898/dengue-virus-transmission-from-living-donor-to-recipient-in-liver-transplantation-a-case-report
#5
Raman K Gupta, Gaurav Gupta, Vishal K Chorasiya, Pradyut Bag, Rajeev Shandil, Vikram Bhatia, Manav Wadhawan, Vivek Vij, Ajay Kumar
Many infections are transmitted from a donor to a recipient through organ transplantations. The transmission of dengue virus from a donor to a recipient in liver transplantation is a rare entity, and currently, there is no recommendation for screening this virus prior to transplantation. We report a case of transmission of dengue virus from donor to recipient after liver transplantation. The recipient had a history of multiple admissions for hepatic encephalopathy and ascites. He was admitted in the ICU for 15 days for chronic liver disease, ascites, and acute kidney injury before transplantation...
March 2016: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/27101228/kidney-transplantation-for-end-stage-renal-disease-secondary-to-familial-mediterranean-fever
#6
Mahmut Altindal, Ercan Turkmen, Tolga Yildirim, Rahmi Yilmaz, Fazil Tuncay Aki, Mustafa Arici, Bulent Altun, Yunus Erdem
Although kidney transplantation (KT) is widely used for treating renal amyloidosis secondary to familial Mediterranean fever (FMF), data concerning transplant outcome are limited and inconsistent. The aim of this study was to determine the long-term outcome of KT in patients with amyloidosis secondary to FMF. Kidney transplantation outcome in 24 patients with FMF was compared to that in 72 controls matched for age, gender of recipient, and type of the donor that underwent KT due to end-stage renal disease (ESRD) not caused by FMF...
July 2016: Clinical Transplantation
https://www.readbyqxmd.com/read/26586067/scedosporium-apiospermum-causing-brain-abscess-in-a-renal-allograft-recipient
#7
Amit Sharma, Divya Singh
Scedosporium apiospermum is the asexual form of a rare fungus Pseudallescheria boydii that is usually present in the soil, sewage and dirty water. In immunocompromised patients, it is a rare infection involving multiple organs. We present a case of renal allograft recipient who developed fever two weeks post renal transplant. He was initially found to have dengue fever. After five days, he became drowsy and developed right-sided hemiparesis. Magnetic resonance imaging of the brain revealed multiple irregular masses with associated edema consistent with fungal brain abscesses...
November 2015: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/26184753/a-multicenter-experience-with-the-surgical-treatment-of-infected-abdominal-aortic-endografts
#8
MULTICENTER STUDY
Victor J Davila, William Stone, Audra A Duncan, Emily Wood, William D Jordan, Nicholas Zea, W Charles Sternbergh, Samuel R Money
OBJECTIVE: Single-center experiences with the treatment of infected endografts after endovascular aortic repair (I-EVAR) have been reported. We performed a multicenter review of the surgical care of these patients to elucidate short-term and long-term outcomes. METHODS: A retrospective analysis of all EVAR explants from 1997 to 2014 at four institutions was performed. Patients with I-EVAR undergoing surgical treatment were reviewed. Data were obtained detailing preoperative demographics, and postoperative morbidity and mortality...
October 2015: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/26064519/rejection-triggered-haemophagocytic-syndrome-in-renal-transplantation-successfully-treated-with-intravenous-immunoglobulin
#9
Igor Denizarde Bacelar Marques, Renato Antunes Caires, Flávio Jota de Paula, William Carlos Nahas, Elias David-Neto
Haemophagocytic syndrome (HPS) is a rare and potentially lethal condition characterized by pancytopoenia, fever, organomegaly and widespread proliferation of macrophages phagocytosing blood elements. Among the triggers of this syndrome, excessive immunosuppression in a context of acute rejection has been rarely reported, although it might be underdiagnosed. Here, we report the case of a kidney transplant recipient with allograft dysfunction due to chronic antibody-mediated rejection treated with antithymocyte globulin and plasmapheresis...
October 2013: Clinical Kidney Journal
https://www.readbyqxmd.com/read/26036499/post-transplant-lymphoproliferative-disorder-a-single-center-experience
#10
H Ferreira, M Bustorff, J Santos, I Ferreira, S Sampaio, I Salomé, J Bastos, R Bergantim, F Príncipe, M Pestana
BACKGROUND: Post-transplant lymphoproliferative disorder (PTLD) is the second most common neoplasia after adult kidney transplantation (KT). METHODS: We retrospectively analyzed 8 adult patients who underwent KT in our center, diagnosed with PTLD between 2001 and 2014. RESULTS: Six patients were men. The median age at presentation was 43 years and the median time since transplantation was 7.3 years. Three patients had previously received anti-thymocyte globulin/OKT3, and all were taking calcineurin inhibitors (CNI) at diagnosis...
May 2015: Transplantation Proceedings
https://www.readbyqxmd.com/read/26033028/dengue-fever-among-renal-transplant-recipients-a-series-of-10-cases-in-a-tropical-country
#11
Silvana Daher Costa, Geraldo Bezerra da Silva, Camilla Neves Jacinto, Lorena Vasconcelos Mesquita Martiniano, Yago Sucupira Amaral, Fernando Jose Villar Nogueira Paes, Maria Luiza De Mattos Brito Oliveira Sales, Ronaldo de Matos Esmeraldo, Elizabeth De Francesco Daher
This is a case series of 10 consecutive renal allograft recipients, followed at a tertiary hospital in northeast Brazil, with a confirmed diagnosis of dengue. Five of the patients needed hospitalization. Half of them were males and age ranged from 19 to 60 years with a median of 38.2 years. They had been transplanted for a mean of 5 days to 166 months. Four patients developed dengue hemorrhagic fever (DHF). All patients had myalgia and headache. All of them, except one, had fever. Positive dengue serology (IgM) was found in all patients...
August 2015: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/25753276/bartonella-henselae-infection-associated-vasculitis-and-crescentic-glomerulonephritis-leading-to-renal-allograft-loss
#12
A R Chaudhry, M R Chaudhry, J C Papadimitriou, C B Drachenberg
Bartonella henselae (BH) is the main cause of cat scratch disease (CSD), which more typically presents as a self-limited localized suppurative lymphadenopathy in immunocompetent individuals. In contrast, immunocompromised patients commonly have systemic disease with life-threatening complications. In addition to the angioproliferative lesions, such as bacillary angiomatosis, an increasing number of immune post-infectious complications are being recognized with BH infections, including glomerulonephritis, vasculitis, hemophagocytic syndrome, and neurological problems...
June 2015: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/25684056/-hemorrhagic-cystitis-due-to-adenovirus-in-a-renal-transplant-recipient-the-first-reported-case-in-black-africa-in-a-setting-of-a-very-beginning-of-a-kidney-transplantation-program-and-review-of-the-literature
#13
Clément Ackoundou-N'Guessan, Noël Coulibaly, Cyr Monley Guei, Denis Aye, Francis Yapi N'guessan, Justin Kouame N'Dah, Delphine Amélie Lagou, Mélanie Weu Tia, Pessa Albert Coulibaly, Sita Nzoue, Serges Konan, Daze Apollinaire Gnionsahe
Viral infections are an important complication of transplantation. Polyomavirus are the commonest viruses that infect the renal allograft. Herpes virus nephropathy has also been described. In the past 15 years, adenovirus nephritis has emerged as a potentially life-threatening disease in renal transplant patients in developed countries. Most of the papers devoted to adenovirus nephritis are reported cases. The fate of such patients in resources-limited countries is not known. Herein, we describe the clinical, biological and prognostic findings of a black African transplanted patient with adenoviral hemorrhagic cystitis...
April 2015: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/25420856/blood-stream-infections-in-renal-transplant-recipients-a-single-center-study
#14
E Daskalaki, M Koukoulaki, A Bakalis, V Papastamopoulos, E Belesiotou, E Perivolioti, A Skoutelis, S Drakopoulos
INTRODUCTION: Bacteremias among renal transplant recipients are more frequent as a result of immunosuppression. They are considered extremely high-risk because they are correlated with decreased allograft and recipient survival. PATIENTS AND METHODS: All episodes of bacteremia among renal transplant recipients were documented following review of medical records, from January 2010 to May 2013. RESULTS: In total 26 episodes of bacteremia were observed in 22 patients...
November 2014: Transplantation Proceedings
https://www.readbyqxmd.com/read/25223377/robotic-trans-abdominal-transplant-nephrectomy-for-a-failed-renal-allograft
#15
M R Mulloy, M Tan, J H Wolf, S H D'Annunzio, H S Pollinger
Minimally invasive surgery for removal of a failed renal allograft has not previously been reported. Herein, we report the first robotic trans-abdominal transplant nephrectomy (TN). A 34-year-old male with Alport's syndrome lost function of his deceased donor allograft after 12 years and presented with fever, pain over his allograft and hematuria. The operation was performed intra-abdominally using the Da Vinci Robotic Surgical System with four trocars. The total operative time was 235 min and the estimated blood loss was less than 25 cm(3)...
December 2014: American Journal of Transplantation
https://www.readbyqxmd.com/read/25179161/successful-treatment-of-acute-severe-graft-versus-host-disease-in-a-pancreas-after-kidney-transplant-recipient-case-report
#16
S Guy, A Potluri, G Xiao, M L Vega, G Malat, K Ranganna, C Cusack, A M Doyle
The development of acute graft-versus-host-disease (GVHD) in recipients of pancreas transplants is a rare and quite often a fatal post-transplantation complication. We present a 38-year-old male with a longstanding history of type 1 diabetes mellitus and end-stage kidney disease, with a living unrelated kidney transplant from his wife for 3 years, who received an enteric-drained 5-antigen HLA-mismatched deceased-donor pancreas. Five weeks after transplantation, he presented with spiking fevers, severe skin rash, diarrhea, pancytopenia, and increasingly abnormal liver function tests...
September 2014: Transplantation Proceedings
https://www.readbyqxmd.com/read/25096644/cutaneous-and-bone-marrow-histoplasmosis-after-18-years-of-renal-allograft-transplant
#17
K Y Ibrahim, N B Carvalho, E V Mimicos, H Yeh-Li, M N Sotto, F O S França
The frequency of histoplasmosis among solid organ transplant (SOT) recipients appears to be low where there are only a few case series, mostly among renal and liver transplant recipients. Herein we report a case of a 44-year-old woman who underwent a living-related renal transplant 18 years prior to evaluation, developed a nodule after followed by ulceration upon her posterior right leg and a second one upon her left leg 3 months and 2 months before her hospitalisation, respectively. The biopsy of lesion revealed the presence of Histoplasma spp...
October 2014: Mycopathologia
https://www.readbyqxmd.com/read/25011572/long-term-complete-remission-of-multiple-extranodal-natural-killer-t-cell-type-posttransplant-lymphoproliferative-disorder-after-surgical-resection-a-case-report
#18
M Matsumura, Y Mizuno, M Okamoto, N Sawa, Y Katayama, N Shimoyama, N Kawagishi, K Miura
BACKGROUND: Posttransplant lymphoproliferative disorder (PTLD) is a life-threatening complication of organ transplantation that results from immunosuppression therapy. Most cases of PTLD derive from the B-cell lineage. T-cell PTLD, particularly natural killer (NK)/T-cell PTLD, is quite rare; only a few cases have been described. CASE REPORT: A 42-year-old woman received a living-related renal allograft from her father. Sixteen years after transplantation, the patient presented with a 1-week history of low-grade fever and epigastralgia...
September 2014: Transplantation Proceedings
https://www.readbyqxmd.com/read/24966111/adenovirus-causing-fever-upper-respiratory-infection-and-allograft-nephritis-complicated-by-persistent-asymptomatic-viremia
#19
A M Lachiewicz, R Cianciolo, M B Miller, V K Derebail
A 20-year-old woman, with renal transplant complicated by recurrence of focal segmental glomerulosclerosis and post-transplant lymphoproliferative disorder, presented nearly 2 years after transplantation with fever, conjunctivitis, and sinus congestion. She was found to have severe adenovirus (ADV)-induced granulomatous interstitial nephritis, confirmed by immunohistochemical staining for ADV in the renal biopsy, without urinary symptoms, hematuria, or laboratory evidence of a change in allograft function. Fever, upper respiratory tract symptoms, and evidence of adenoviral infection in the allograft resolved with decreased immunosuppression and treatment with cidofovir and intravenous immunoglobulin...
August 2014: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/24885965/a-rare-case-of-cytomegalovirus-scedosporium-apiospermum-and-mycobacterium-tuberculosis-in-a-renal-transplant-recipient
#20
Manish Rathi, Srikant Gundlapalli, Raja Ramachandran, Sandeep Mohindra, Harsimran Kaur, Vivek Kumar, Harbir Singh Kohli, Krishan Lal Gupta, Vinay Sakhuja
BACKGROUND: Renal transplant recipients are at high risk of developing multiple infections, often concomitantly because of their immunocompromised status. Post renal transplant infections are often elusive and require extensive evaluation for proper diagnosis and treatment. A high index of suspicion is required and an attempt should be made to confirm the microbiological diagnosis from each site involved to rule out multiple infections. CASE PRESENTATION: We report a 50-year-old female, a renal allograft recipient who presented with left hemiplegia, esophageal ulcers and fever 3 months after her transplant...
2014: BMC Infectious Diseases
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