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JOURNAL ARTICLE
Lukas Kellermair, Christoph Höfer, Matthias W G Zeller, Christa Kubasta, Dave Bandke, Serge Weis, Jörg Kellermair, Thomas Forstner, Raimund Helbok, Milan R Vosko
BACKGROUND AND PURPOSE: Cerebral sinus venous thrombosis (CSVT) is a rare but life-threatening disease and its diagnosis remains challenging. Blood biomarkers, including D-Dimer are currently not recommended in guidelines. Soluble endothelial receptor proteins (sICAM-1, sPECAM-1 and sVCAM-1) have been shown to be promising diagnostic biomarkers in deep vein thrombosis (DVT) and pulmonary embolism (PE). Therefore, we examined endothelial receptor proteins as potential biomarkers for detecting CSVT...
April 5, 2024: Journal of Neurology
#22
JOURNAL ARTICLE
Yassine Kilani, Mohammad Aldiabat, Chee Yao Lim, Syeda Ashna Fatima Kamal, Priscila Castro Puelo, Ammar Vohra, Vikash Fnu, Alsakarneh Saqr, Maria Kassab, Adam S Faye
BACKGROUND: Data detailing the risk of Venous Thromboembolism (VTE) subtypes among individuals with Inflammatory bowel disease (IBD) remain limited. Aims: We looked to assess the odds of VTE subtypes among hospitalized individuals with IBD as compared to those without IBD. MATERIALS & METHODS: Using the Nationwide Inpatient Sample database, we applied a multivariable regression analysis to compare the odds of primary VTE-related hospitalizations among individuals with and without IBD from 2016 to 2020, including deep venous thrombosis (DVT), pulmonary embolism (PE), portal vein thrombosis (PVT), Budd Chiari syndrome (BCS), renal vein thrombosis (RVT), and cerebral venous sinus thrombosis (CVST)...
2024: Clin Res Clin Trials
#23
REVIEW
Aadarsh Netha, Saad Mazhar, Aima Azhar, Abdul Moeez, Aakash Choradia, Ali Mohtashim, Usama Anees, Umer Ejaz, Muhammad Uzair Tariq, Sayed Jawad
BACKGROUND: Cerebral venous thromboembolism (CVT) poses a significant risk of venous infarction and haemorrhage, which can lead to neurological deficits and, in severe cases, even death. The optimal treatment regimen for patients with CVT remains unclear. METHODS: MEDLINE, Embase, Google Scholar, Web of Science (WoS), and Cochrane Central databases were searched for randomized controlled trials (RCTs) and observational studies assessing the efficacy and safety of rivaroxaban in patients with CVT...
April 2024: Annals of Medicine and Surgery
#24
REVIEW
Jr-Wei Wu, Shuu-Jiun Wang
Spontaneous intracranial hypotension (SIH) typically presents as an acute orthostatic headache during an upright position, secondary to spinal cerebrospinal fluid leaks. New evidence indicates that a lumbar puncture may not be essential for diagnosing every patient with SIH. Spinal neuroimaging protocols used for diagnosing and localizing spinal cerebrospinal fluid leaks include brain/spinal MRI, computed tomography myelography, digital subtraction myelography, and radionuclide cisternography. Complications of SIH include subdural hematoma, cerebral venous thrombosis, and superficial siderosis...
May 2024: Neurologic Clinics
#25
JOURNAL ARTICLE
Adrian Scutelnic, Anita van de Munckhof, Angel T Miraclin, Sanjith Aaron, Sajid Hameed, Mohammad Wasay, Oxana Grosu, Katarzyna Krzywicka, Mayte Sánchez van Kammen, Erik Lindgren, Tiago Moreira, Roberto Acampora, Alberto Negro, Theodoros Karapanayiotides, Shadi Yaghi, Anna Revert, Elisa Cuadrado Godia, Sebastian Garcia-Madrona, Paolino La Spina, Francesco Grillo, Fabrizio Giammello, Thanh N Nguyen, Mohamad Abdalkader, Alina Buture, Maria Sofia Cotelli, Nicolas Raposo, Georgios Tsivgoulis, Paolo Candelaresi, Antonio Ciacciarelli, Joshua Mbroh, Tatiana Batenkova, Pasquale Scoppettuolo, Marialuisa Zedde, Rosario Pascarella, Kateryna Antonenko, Espen S Kristoffersen, Johanna A Kremer Hovinga, Katarina Jood, Diana Aguiar de Sousa, Sven Poli, Turgut Tatlisumak, Jukka Putaala, Jonathan M Coutinho, José M Ferro, Marcel Arnold, Mirjam R Heldner
INTRODUCTION: Previous reports and meta-analyses derived from small case series reported a mortality rate of up to 40% in patients with coronavirus disease 2019 associated cerebral venous thrombosis (COVID-CVT). We assessed the clinical characteristics and outcomes in an international cohort of patients with COVID-CVT. PATIENTS AND METHODS: This was a registry study of consecutive COVID-CVT patients diagnosed between March 2020 and March 2023. Data collected by the International Cerebral Venous Thrombosis Consortium from patients with CVT diagnosed between 2017 and 2018 served as a comparison...
April 4, 2024: European Stroke Journal
#26
JOURNAL ARTICLE
Sanjit Aaron, Jorge M Ferreira, Jonathan M Coutinho, Patrícia Canhão, Adriana B Conforto, Antonio Arauz, Marta Carvalho, Jaime Masjuan, Vijay K Sharma, Jukka Putaala, Maarten Uyttenboogaart, David J Werring, Rodrigo Bazan, Sandeep Mohindra, Jochen Weber, Bert A Coert, Prabhu Kirubakaran, Mayte Sanchez van Kammen, Pankaj Singh, Diana Aguiar de Sousa, José M Ferro
BACKGROUND: Decompressive neurosurgery is recommended for patients with cerebral venous thrombosis (CVT) who have large parenchymal lesions and impending brain herniation. This recommendation is based on limited evidence. We report long-term outcomes of patients with CVT treated by decompressive neurosurgery in an international cohort. METHODS: DECOMPRESS2 (Decompressive Surgery for Patients With Cerebral Venous Thrombosis, Part 2) was a prospective, international cohort study...
April 4, 2024: Stroke; a Journal of Cerebral Circulation
#27
JOURNAL ARTICLE
Mehmet Özkan, Ahmet Güner, Sabahattin Gündüz, Gazi Yıldız, Ayşe İnci Yıldırım, Macit Kalçık, Mahmut Yesin, Emrah Bayam, Semih Kalkan, Mustafa Ozan Gürsoy, Alev Kılıçgedik, Zübeyde Bayram, Münevver Sarı, Mehmet Aytürk, Süleyman Karakoyun, Mehmet Ali Astarcıoğlu, Elif Cansu Gündoğdu, Asuman Biçer, Emre Gürcü, Tuncer Koçak, Recep Demirbağ
BACKGROUND: Optimal first-trimester anticoagulation is still challenging in pregnant women with mechanical heart valves (MHVs) requiring high-dose warfarin.This multicenter prospective study aims to determine the optimal anticoagulation regimens for pregnant patients with MHVs. METHODS: All women were allocated to one of three treatment options during first trimester including lone low-molecular-weight heparin (LMWH), combination of LMWH+2.5 mg warfarin, and LMWH+4 mg warfarin...
April 1, 2024: American Heart Journal
#28
Shruti Jain, Mehak Bhushan, Vandana Talwar
INTRODUCTION: Cerebral venous sinus thrombosis (CVST) is a rare and life-threatening condition that may be encountered during pregnancy and puerperium. The diagnosis of CVST is a challenge because of its varied presentation. CASE REPORT: A 28-year-old woman presented with headache, projectile vomiting, and generalized tonic-clonic seizures 10 days after delivery by cesarean section. She had an uneventful antenatal period of 38 weeks of gestation. High clinical suspicion and the availability of magnetic resonance venography helped in making a diagnosis of CVST...
2024: Qatar Medical Journal
#29
JOURNAL ARTICLE
Andrea Galeazzo Rigutini
Introduction: Patients with ischemic stroke (IS) and atrial fibrillation (AF) face a higher risk of recurrent vascular events. This study evaluates the impact of atherosclerotic vascular disease burden across different vascular territories on the risk of vascular events in patients with recent ischemic stroke and AF within 90 days. Patients and Methods: We included patients with IS and AF from the International RAF network in a prospective 90-day follow-up. Atherosclerotic vascular disease was identified by at least one of the following: Symptomatic ischemic heart disease, symptomatic peripheral artery disease, internal carotid stenosis ≥50%, or the presence of plaques in the aorta...
2024: Clinical and Applied Thrombosis/hemostasis
#30
JOURNAL ARTICLE
Li Ma, He Zhang, Guangxin Duan, Yun Luo, Xi Zhang, Zhengjuan Lu, Zhibin Chen, Linjie Yu, Tingzheng Zhang, Yun Xu, Jingwei Li
BACKGROUND: Enterprise stent was approved for the treatment of wide-necked intracranial aneurysms. However, it has been widely used in the endovascular treatment of intracranial artery stenosis, which is still controversial. The purpose of this study was to evaluate the safety and efficiency of the Enterprise stent in the endovascular treatment of intracranial artery stenosis disease. METHODS: We conducted a retrospective case series of 107 patients with intracranial artery stenosis who received Enterprise stent implantation at Nanjing Drum Tower Hospital from January 2020 to December 2022...
April 1, 2024: Neurological Research
#31
JOURNAL ARTICLE
Vittorio Pengo, Luca Sarti, Emilia Antonucci, Elisa Bison, Elena Pontara, Maria Grazia Cattini, Gentian Denas, Daniela Poli, Gualtiero Palareti
OBJECTIVES: Thrombosis in antiphospholipid syndrome (APS) involves in most cases the venous circulation . Why in some patients thrombotic APS affects the arterial circulation and in particular cerebral circulation is unknown. In previous studies, both patient characteristics and antiphospholipid antibody types and titers have been associated with arterial thrombosis. Aim of this study was to compare the clinical characteristics and laboratory findings of venous and arterial thrombotic APS from a large series of patients...
April 2, 2024: Clinical Chemistry and Laboratory Medicine: CCLM
#32
JOURNAL ARTICLE
João André Sousa, Maider Iza Achutegui, Jesus Juega-Mariño, Manuel Requena, Sara Bernardo-Castro, Marc Rodrigo-Gisbert, Federica Rizzo, Marta Olivé, Álvaro Garcia-Tornel, Ana Carolina Chaves, Noelia Rodriguez-Villatoro, Marian Muchada, Jorge Pagola, David Rodriguez-Luna, Marta Rubiera, Ana Inês Martins, Fernando Silva, Ricardo Veiga, Cesar Nunes, Egídio Machado, Francesco Diana, Marta de Dios, David Hernández, Marc Ribo, Carlos Molina, João Sargento-Freitas, Alejandro Tomasello
INTRODUCTION: After several uncontrolled studies and one randomized clinical trial, there is still uncertainty regarding the role of endovascular treatment (EVT) in cerebral venous thrombosis (CVT). This study aims to describe and assess different acute management strategies in the treatment of CVT. METHODS: We performed a retrospective analysis of an international two-center registry of CVT patients admitted since 2019. Good outcome was defined as a return to baseline modified Rankin scale at three months...
March 31, 2024: Interventional Neuroradiology
#33
JOURNAL ARTICLE
Jie Chen, Bingbing Ye, Feng Lin, Wenchao Cai, Rui Chen, Zhanwei Ruan
PURPOSE: Severe traumatic brain injury (sTBI) patients often experience stress hyperglycaemia, which can lead to negative outcomes. This study aims to introduce an effective insulin infusion protocol specifically designed for sTBI patients. METHODS: Data was collected from all sTBI patients during two periods: 1 October 2019 to 30 April 2020, and 1 June 2020 to 31 December 2020. In May 2020, a new insulin infusion protocol was implemented. Blood glucose management, infection, coagulation, and prognosis were compared in these two periods...
March 2024: Endocrinología, diabetes y nutrición
#34
JOURNAL ARTICLE
Isaac Pons, Alba Jeréz, Gerard Espinosa, Ignasi Rodríguez-Pintó, Doruk Erkan, Yehuda Shoenfeld, Ricard Cervera
OBJECTIVE: To analyze the demographic, clinical, and laboratory characteristics of catastrophic antiphospholipid syndrome (CAPS) patients with cardiac involvement, and to identify the factors associated with this cardiac involvement. MATERIAL AND METHODS: Based on the analysis of the "CAPS Registry", the demographic, clinical, and serological characteristics of patients with cardiac involvement were analyzed. Cardiac involvement was defined as heart failure, valvular disease, acute myocardial infarction, pericardial effusion, pulmonary arterial hypertension, systolic dysfunction, intracardiac thrombosis, and microvascular disease...
March 26, 2024: Seminars in Arthritis and Rheumatism
#35
JOURNAL ARTICLE
Saleh A Algarni, Naif S ALGhasab, Mohammed S Alharbi, Anas Albarrak, Ahmad A Alanezi, Hamdan M Al Shehri
Cerebral venous sinus thrombosis (CVST) is a rare neurovascular condition that has been observed in individuals with coronavirus disease 2019 (COVID-19). This systematic review aimed to explore the sex differences and characteristics of concurrent COVID-19 and CVST cases. A total of 212 CVST patients were included in the study. Women with CVST had a slightly higher mean age compared to men (47.359 years vs 46.08 years). Women were more likely to report symptoms such as fever (56.1%) and decreased sense of smell or taste (71...
2024: Clinical and Applied Thrombosis/hemostasis
#36
BioMed Research International
[This retracts the article DOI: 10.1155/2020/6637692.].
2024: BioMed Research International
#37
JOURNAL ARTICLE
W Wang, Q Jia, S B Wang, X D Li, Y M Fan
Objective: To explore the clinical characteristics of neutrophil extracellular trap (NET) in patients with severe cerebral venous sinus thrombosis (CVST) and to study their prognostic value in the acute and subacute phases. Methods: This study is a retrospective case series analysis. Clinical and pathological data of 52 patients with severe cerebral venous sinus thrombosis who underwent endovascular treatment in the Department of Neurosurgery, Tianjin Huanhu Hospital from June 2019 to June 2022 were retrospectively analyzed...
March 27, 2024: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
#38
REVIEW
Maki Tsujita, John T Melchior, Shinji Yokoyama
The brain is the most lipid-rich organ in the body, and the intricate interplay between lipid metabolism and pathologies associated with neurodegenerative disorders is being increasingly recognized. The brain is bathed in cerebrospinal fluid (CSF), which, like plasma, contains lipid-protein complexes called lipoproteins that are responsible for extracellular lipid transport. Multiple CSF lipoprotein populations exist, some of which are produced de novo in the central nervous system and others that appear to be generated from protein constituents that are produced in the periphery...
March 28, 2024: Arteriosclerosis, Thrombosis, and Vascular Biology
#39
JOURNAL ARTICLE
Giuseppe Vadalà, Vincenzo Sucato, Francesco Costa, Fausto Castriota, Roberto Nerla, Giuseppe Roscitano, Antonio Giovanni Versace, Alfredo Ruggero Galassi, Antonio Micari
AIMS: To describe through emblematic images rare but clinically relevant carotid artery stenting complications that occurred at two high-volume centres for carotid artery stenting (CAS). BACKGROUND: CAS is an alternative to carotid endarterectomy (CEA) for the treatment of carotid artery stenosis in patients judged to be at high risk for CEA. CAS complications range between 1 and 9% and are higher in older patients complaining of neurological symptoms at the time of presentation...
February 26, 2024: Journal of Personalized Medicine
#40
JOURNAL ARTICLE
Li Li, Bu-Lang Gao, Qiao-Wei Wu, Qiu-Ji Shao, Zi-Liang Wang, Kun Zhang, Tian-Xiao Li
To investigate the safety and effect of Tubridge flow diverter deployment for the treatment of intracranial aneurysms, 85 patients with intracranial aneurysms treated with the Tubridge flow diverter were retrospectively enrolled. The clinical data including the baseline data, aneurysm parameters before and after treatment, and follow-up outcomes were assessed. Among 85 patients, there were 35 (41.2%) males and 50 females (58.8%) aged 17-77 (mean 56.7 ± 11.1) years with 110 aneurysms. Five (5...
March 27, 2024: Scientific Reports
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