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Vinicius Zanetti, Christopher Carling, Marcelo S Aoki, Paul S Bradley, Alexandre Moreira
Zanetti, V, Carling, C, Aoki, MS, Bradley, PS, and Moreira, A. Are there differences in elite youth soccer player work rate profiles in congested vs. regular match schedules? J Strength Cond Res XX(X): 000-000, 2018-Official international tournaments in which youth soccer players participate can involve very congested schedules. Yet, no information regarding physical and technical match performance during congested vs. regular (noncongested) cycles is available. In this study, accelerations, decelerations, mean metabolic power (MP), and technical performance (offensive and defensive variables) were compared across very congested match (VCM; 10 international matches played over 3 successive days, including 2 days with 2 consecutive matches separated by a 4- to 5-hour interval) and 10 regular (noncongested match [NCM]) match periods in elite male Under 15 (U15, n = 11) and Under 17 (U17, n = 13) soccer players...
June 21, 2018: Journal of Strength and Conditioning Research
Chao Fang, Ronghui Zheng, Yusheng Zhang, Fukun Hong, Jingli Mu, Mengyun Chen, Puqing Song, Longshan Lin, Heshan Lin, Fengfeng Le, Jun Bo
The seafloor is recognized as one of the major sinks for microplastics (MPs). However, to date there have been no studies reported the MP contamination in benthic organisms from the Arctic and sub-Arctic regions. Therefore, this study provided the first data on the abundances and characteristics of MPs in a total of 413 dominant benthic organisms representing 11 different species inhabiting in the shelf of Bering and Chukchi Seas. The mean abundances of MP uptake by the benthos from all sites ranged from 0...
June 14, 2018: Chemosphere
Fusun Citak-Er, Zeynep Firat, Ilhami Kovanlikaya, Ugur Ture, Esin Ozturk-Isik
OBJECTIVE: The objective of this study was to assess the contribution of multi-parametric (mp) magnetic resonance imaging (MRI) quantitative features in the machine learning-based grading of gliomas with a multi-region-of-interests approach. MATERIALS AND METHODS: Forty-three patients who were newly diagnosed as having a glioma were included in this study. The patients were scanned prior to any therapy using a standard brain tumor magnetic resonance (MR) imaging protocol that included T1 and T2-weighted, diffusion-weighted, diffusion tensor, MR perfusion and MR spectroscopic imaging...
June 15, 2018: Computers in Biology and Medicine
John Bennet Carow, Juliane Carow, Boyko Gueorguiev, Kajetan Klos, Christian Herren, Miguel Pishnamaz, Christian David Weber, Sven Nebelung, Bong-Sung Kim, Matthias Knobe
PURPOSE: Open reduction and internal fixation (ORIF) using an extended lateral approach combined with plate osteosynthesis represents the current gold standard in calcaneal fracture treatment, but it is associated with a wound complication rate of up to 30%. Literature suggests that micro-circulation is one of the key factors for sufficient wound healing. The aim of this study was to evaluate soft tissue micro-circulation of the hindfoot in healthy volunteers to determine influencing factors and to identify hypoxic or hypoperfused areas in non-trauma situations, with special attention to surgical approaches...
June 22, 2018: International Orthopaedics
Rohan Medhekar, Rajender Aparasu, Vinod Bhatara, Michael Johnson, Joy Alonzo, Heidi Schwarzwald, Hua Chen
OBJECTIVE: To examine patient and provider characteristics associated with the use of pediatric psychotropic polypharmacy. METHODS: A retrospective study was conducted on children with psychiatric disorder diagnosis and treatment using the 2013-2015 claims data from a Pediatric Medicaid Managed Care Plan. Psychotropic polypharmacy was defined as the receipt of ≥2 psychotropic medications from different drug classes concurrently for ≥60 days. Stratified logistic regression analyses based on the number of prescribers involved in the treatment, i...
June 13, 2018: Research in Social & Administrative Pharmacy: RSAP
Adi Tabib, Issam Hindi, Netanel Karbian, Orly Zelig, Batla Falach, Dror Mevorach
BACKGROUND: Thrombosis is the prognostic factor with the greatest effect on survival in patients with paroxysmal nocturnal hemoglobinuria (PNH), who lack dozens of membrane surface proteins. We recently described a primary homozygous Cys89Tyr congenital nonfunctioning CD59 in humans with clinical manifestation in infancy, associated with chronic hemolysis, recurrent strokes, and relapsing peripheral demyelinating neuropathy. Here we investigated hypercoagulability mechanisms characterizing the syndrome...
June 11, 2018: Thrombosis Research
Dongmiao Chen, Yajie Zhang, Yinjuan Xu, Tingting Shen, Guorui Cheng, Bingkang Huang, Xiandong Ruan, Congrong Wang
Objective: This study aimed to compare the performance of chemiluminescence immunoassay (CLIA), enzyme-linked immunosorbent assay (ELISA), and passive agglutination (PA) method in detecting Mycoplasma pneumoniae (MP) infection. Methods: This study enrolled a total of 280 patients who were consecutively seen at the Nanfang Hospital of the Southern Medical University in Guangdong Province, China, between August and December 2016. Serum was collected and examined by CLIA, ELISA, and PA, respectively...
2018: Therapeutics and Clinical Risk Management
Chui Ching Wong, Siew Hoon Lim, Chai Teng Tan, Sook Yin Lui, Yee Leng Lee, Kwai Peng Chan
In view of recent revised recommendations for human immunodeficiency virus (HIV) confirmatory testing, the performance of 3 HIV confirmatory assays was compared. Using the HIV Blot 2.2 (MP-WB), the INNO-LIA HIV I/II Score (INNO), and the Geenius HIV 1/2 Confirmatory Assay (Geenius), we tested 199 HIV-1 positive, 161 HIV negative, 65 HIV western blot indeterminate, 26 HIV seroconversion, 34 early HIV infection and 4 HIV-2 positive archived specimens. We show that all 3 assays had comparable test sensitivity in the detection of HIV-1 positive cases...
2018: PloS One
Xaver Sewald
Viral pathogens have adapted to the host organism to exploit the cellular machinery for virus replication and to modulate the host cells for efficient systemic dissemination and immune evasion. Much of our knowledge of the effects that virus infections have on cells originates from in vitro imaging studies using experimental culture systems consisting of cell lines and primary cells. Recently, intravital microscopy using multi-photon excitation of fluorophores has been applied to observe virus dissemination and pathogenesis in real-time under physiological conditions in living organisms...
June 20, 2018: Viruses
Xin Yuan, Changqing Bai, Qian Cui, Han Zhang, Jing Yuan, Kaiwen Niu, Yuzhong Feng, Xin Jin, Puyuan Li, Huiying Liu
To improve the diagnosis and treatment of Mycoplasma pneumoniae (Mp) infection and reduce the misuse of antibiotics, we sought to establish a loop-mediated isothermal amplification (LAMP) assay for rapid detection of Mp.Six primers specific for the Mp P1 gene were designed, and the LAMP method was used to rapidly detect Mp. The sensitivity of the LAMP method was determined by serial dilution of the standard Mp strain FH (standard strains of Mycoplasma pneumoniae). Specificity was assessed with 17 common pathogenic microorganisms in the respiratory tract...
June 2018: Medicine (Baltimore)
Ilje Pikaar, Silvio Matassa, Benjamin L Bodirsky, Isabelle Weindl, Florian Humpenöder, Korneel Rabaey, Nico Boon, Michele Bruschi, Zhiguo Yuan, Hannah van Zanten, Mario Herrero, Willy Verstraete, Alexander Popp
One of the main challenges for the 21st century is to balance the increasing demand for high-quality proteins while mitigating environmental impacts. In particular, cropland-based production of protein-rich animal feed for livestock rearing results in large-scale agricultural land-expansion, nitrogen pollution, and greenhouse gas emissions. Here we propose and analyze the long-term potential of alternative animal feed supply routes based on industrial production of microbial proteins (MP). Our analysis reveals that by 2050, MP can replace, depending on socio-economic development and MP production pathways, between 10-19% of conventional crop-based animal feed protein demand...
June 20, 2018: Environmental Science & Technology
Barbara Grajewski, Lee C Yong, Stephen J Bertke, Parveen Bhatti, Mark P Little, Marilyn J Ramsey, James D Tucker, Elizabeth M Ward, Elizabeth A Whelan, Alice J Sigurdson, Martha A Waters
BACKGROUND: Chromosome translocations are a biomarker of cumulative exposure to ionizing radiation. We examined the relation between the frequency of translocations and cosmic radiation dose in 83 male airline pilots. METHODS: Translocations were scored using fluorescence in situ hybridization chromosome painting. Cumulative radiation doses were estimated from individual flight records. Excess rate and log-linear Poisson regression models were evaluated. RESULTS: Pilots' estimated median cumulative absorbed dose was 15 mGy (range 4...
July 1, 2018: Aerospace Medicine and Human Performance
Claire Kelly, Marinos Pericleous, Jane Hendy, Simon de Lusignan, Ayesha Ahmed, Tushna Vandrevala, Aftab Ala
BACKGROUND: Screening programmes are well established in cancer, and are now being implemented in other conditions. An effective screening programme leads to early disease detection and improved outcomes but its impact is dependent on the quality of the test and the proportion of the target population participating. A further consideration is that uptake of screening by minority groups is low. PURPOSE: To determine which interventions have successfully increased screening uptake amongst minorities...
June 19, 2018: International Journal of Clinical Practice
Elizabeth Spencer, Evan Norris, Chadwick Williams, Marla C Dubinsky
Background: Thiopurine metabolite monitoring to proactively dose optimize to achieve therapeutic levels has not been used consistently, and it is unclear if this would lead to better outcomes. We aimed to compare 6-month outcomes between standard and optimized dosing strategies and define long-term predictors of thiopurine durability. Methods: Two hundred sixteen pediatric IBD patients with at least 2 6-thioguanine nucleotide (6-TGN) levels were grouped for analysis by start dose: >2...
June 16, 2018: Inflammatory Bowel Diseases
Anne Grosen, Jacob Nersting, Mona Bungum, Lisbet Ambrosius Christensen, Kjeld Schmiegelow, Marcello Spanò, Mette Julsgaard, Eugenia Cordelli, Giorgio Leter, Peter Braad Larsen, Christian Lodberg Hvas, Jens Kelsen
Background & Aims: Sperm DNA integrity, concentration and motility are suspected to be altered by thiopurines (azathioprine (AZA) and 6-mercaptopurine (6-MP)). We investigated the impact of thiopurines on semen quality in men with inflammatory bowel disease (IBD) by a comprehensive panel of semen analyses. Methods: Semen from 40 men with IBD in remission on AZA/6-MP therapy was prospectively collected and compared with samples from 40 healthy volunteers. Paired samples (off and on AZA/6-MP) were obtained from a subset of IBD patients, and blood and semen were collected to determine 6-MP transmission to the ejaculate...
June 16, 2018: Journal of Crohn's & Colitis
Sozaburo Ihara, Yoshihiro Hirata, Yohko Hikiba, Aya Yamashita, Mayo Tsuboi, Masahiro Hata, Mitsuru Konishi, Nobumi Suzuki, Kosuke Sakitani, Hiroto Kinoshita, Yoku Hayakawa, Hayato Nakagawa, Hideaki Ijichi, Keisuke Tateishi, Kazuhiko Koike
Background and Aims: Disturbance of intestinal homeostasis is associated with the development of inflammatory bowel disease (IBD), and TGF-β signaling impairment in mononuclear phagocytes (MPs) causes murine colitis with goblet cell depletion. Here, we examined an organoid-MP co-culture system to study the role of MPs in intestinal epithelial differentiation and homeostasis. Methods: Intestinal organoids were co-cultured with lamina propria leukocytes and bone marrow-derived dendritic cells (BMDCs) from CD11c-cre Tgfbr2fl/fl mice...
June 16, 2018: Journal of Crohn's & Colitis
Ali Küpeli, Ayşegül Cansu, Şükrü Oğuz, Süleyman Bekirçavuşoğlu, Süha Türkmen, Ali Ahmetoğlu, Gürkan Danışan
Background/aim: This study aimed to investigate the prevalence and association of mesenteric panniculitis (MP) with other diseases and the clinicoradiological features of MP, and to examine computed tomography findings to estimate the presence of malignancy in patients with MP. Materials and methods: Between September 2012 and August 2016, we used a keyword search to identify patients diagnosed with MP. Associated diseases and malignancies of patients were recorded. Cut-off values and diagnostic efficiencies of total MP scores and short and long diameters of the greatest lymph nodes were determined...
June 14, 2018: Turkish Journal of Medical Sciences
Anna L Valjakka, Sanna Salanterä, Aarno Laitila, Juhani Julkunen, Nora M Hagelberg
Background and aim Physicians' attitudes predict clinical decision making and treatment choices, but the association between attitudes and behaviour is complex. Treatment guidelines for non-specific low back pain (LBP) include recommendations of early assessment of psychosocial risk factors forchronic pain, patient education and reassurance. Implication of these principles is demanding, and many patients are not referred for appropriate treatments due to a lack of systematic screening of psychosocial risk factors for chronic pain...
December 29, 2017: Scandinavian Journal of Pain
Xuehui Wu, Huizeng Sun, Mingyuan Xue, Diming Wang, Le Luo Guan, Jianxin Liu
Milk yield (MY) and milk protein (MP) content are crucial milk performance traits of dairy cows that directly affect the dairy profits. This study first proposed milk protein yield (MPY) by considering MY and MP content together. Forty multiparous cows were selected from the 348 Holstein dairy cows, which fed the same diet under the same management condition, to investigate the serum metabolome profiles and to identify key metabolites associated with MPY. Among them, 20 cows with a higher MPY (MY > 34...
June 15, 2018: Journal of Proteomics
Si-Woon Park, Jae-Hyung Kim, Yun-Jung Yang
Mental practice (MP) is usually provided in combination with other therapies, and new developments for neurofeedback to support MP have been made recently. The objectives of this study were to evaluate the effectiveness of MP and to investigate the intervention characteristics including neurofeedback that may affect treatment outcome. The Cochrane Central Register of Controlled Trials, PubMed, Embase, KoreaMed, Scopus, Web of Science, PEDro, and CIRRIE were searched from inception to March 2017 for randomized controlled trials to assess the effect of MP for upper limb rehabilitation after stroke...
June 14, 2018: International Journal of Rehabilitation Research. Revue Internationale de Recherches de Réadaptation
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