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https://www.readbyqxmd.com/read/29222865/multipoint-pacing-improves-peripheral-hemodynamic-response-non-invasive-assessment-using-radial-artery-tonometry
#1
Giuseppe Ciconte, Žarko Ćalović, Gabriele Vicedomini, Amarild Cuko, Luke C McSpadden, Chunlan Jiang, Kyungmoo Ryu, Igor Caporaso, Robert Stutz, Dean Winter, Massimo Saviano, Raffaele Vitale, Manuel Conti, Vincenzo Santinelli, Carlo Pappone
BACKGOUND: Multipoint left ventricular (LV) pacing (MultiPoint™ Pacing [MPP], Abbott) improves the response rate to cardiac resynchronization therapy (CRT). We evaluated the feasibility of non-invasive radial artery tonometry (RAT) to characterize arterial pressure morphology changes (pre-ejection period [PEP] and ejection duration [ED]) between conventional CRT and MPP pacing interventions. METHODS: Patients with a MPP-enabled CRT device (Quadra Assura MP™, Abbott) underwent non-invasive RAT assessment (SphygmoCor CVMS, AtCor Medical Inc...
December 9, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29221890/22nd-international-conference-on-medical-physics-2016-bangkok-thailand-medical-physics-propelling-global-health
#2
EDITORIAL
Virginia Tsapaki, Geoff Ibbott, Anchali Krisanachinda, Kwan-Hoong Ng, Tae-Suk Suh, Slavik Tabakov, John Damilakis
As medical technology evolves and patient needs increase, the need for well-trained and highly professional medical physicists (MPs) becomes even more urgent. The roles and responsibilities of MPs in various departments within the hospital are diverse and demanding. It is obvious that training, continuing education and professional development of MPs have become essential. One of the ways for an MP to advance his or her knowledge is to participate in conferences and congresses. Last year, the 22nd International Conference of Medical Physics (ICMP 2016) took place in Bangkok, Thailand...
December 6, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/29220161/sequential-migrations-between-boron-and-rhodium-centers-a-cooperative-process-between-rhodium-and-a-monosubstituted-borohydride-unit
#3
Angelo Iannetelli, Graham Tizzard, Simon J Coles, Gareth R Owen
The sodium salt of a monosubstituted borohydride anion containing a 2-mercaptopyridyl unit (mp) is reported herein. This compound was coordinated to a rhodium(I) center providing the complex [Rh{κ3-H,H,S-H3B(mp)}(NBD)] (1) (where NBD = 2,5-norbornadiene) in which the boron-based ligand is coordinated to the rhodium center via the thione donor and two of the B-H bonds of the BH3 unit. Reaction of complex 1 with carbon monoxide results in the activation of the complex leading to the product of a formal intramolecular hydroboration reaction, where the NBD unit has, in effect, inserted into one of the B-H bonds...
December 8, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29220051/improving-extraction-and-post-purification-concentration-of-membrane-proteins
#4
Hasin Feroz, HyeYoung Kwon, Jing Peng, Hyeonji Oh, Bryan Ferlez, Carol S Baker, John H Golbeck, Guillermo C Bazan, Andrew L Zydney, Manish Kumar
Membrane proteins (MPs), despite being critically important drug targets for the pharmaceutical industry, are difficult to study due to challenges in obtaining high yields of functional protein. Most current extraction efforts use specialized non-ionic detergents to solubilize and stabilize MPs, with MPs being concentrated by ultrafiltration (UF). However, many detergents are retained during the UF step, which can destabilize MPs and/or interfere with their characterization. Here, we studied the influence of detergent selection on the extraction and UF-based concentration of biomedically-relevant MPs, the light-driven sodium and chloride transporters, KR2 and halorhodopsin (pHR) which are also model proteins for more complex mammalian rhodopsins...
December 8, 2017: Analyst
https://www.readbyqxmd.com/read/29218968/the-psychiatry-integrated-nurse-practitioner-role-in-hemodialysis-an-opportunity-to-provide-nurse-practitioner-care-between-the-interface-of-psychiatry-and-hemodialysis
#5
Brock Cooper, Kien Dang, Ann Jones, Alison Thomas
The mental health of patients living with end-stage kidney disease (ESKD) is an important aspect of their care. According to national survey data, depressive disorders affect about 9% of the North American population (Kessler, Chiu, Demler, Merikangas, & Walters, 2005). A review of psychological distress and depression across the spectrum of chronic kidney disease indicates that the prevalence of depression in ESKD is reported to be about four times that of the general population and it is associated with adverse outcomes including low quality-of-life ratings, graft failure, and death after renal transplantation (Zalai, Szeifert, & Novak, 2012)...
January 2017: CANNT Journal, Journal ACITN
https://www.readbyqxmd.com/read/29218884/how-powerful-are-summary-based-methods-for-identifying-expression-trait-associations-under-different-genetic-architectures
#6
Yogasudha Veturi, Marylyn D Ritchie
Transcriptome-wide association studies (TWAS) have recently been employed as an approach that can draw upon the advantages of genome-wide association studies (GWAS) and gene expression studies to identify genes associated with complex traits. Unlike standard GWAS, summary level data suffices for TWAS and offers improved statistical power. Two popular TWAS methods include either (a) imputing the cis genetic component of gene expression from smaller sized studies (using multi-SNP prediction or MP) into much larger effective sample sizes afforded by GWAS - TWAS-MP or (b) using summary-based Mendelian randomization - TWAS-SMR...
2018: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/29218786/how-fast-can-treatment-with-overdentures-improve-the-masticatory-function-and-ohrqol-of-atrophic-edentulous-patients-a-1-year-longitudinal-clinical-study
#7
Raissa Micaella Marcello-Machado, Fernanda Faot, Alessandra Julie Schuster, Amália Machado Bielemann, Gustavo Giacomelli Nascimento, Altair Antoninha Del Bel Cury
OBJECTIVES: The aim of this prospective clinical study was to evaluate the masticatory function (MF) and subjective perception of patients with poor denture-bearing tissue in relation to change and the time required to identify an improvement in these parameters after rehabilitation with mandibular overdentures (MO) by two narrow-diameter two-piece implants. MATERIAL AND METHODS: Twenty-three edentulous patients were selected for MO installation. The masticatory function (MF) was evaluated with the masticatory performance (MP) and swallowing threshold (ST) tests...
December 7, 2017: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/29217358/lack-of-agreement-between-objective-and-subjective-measures-in-the-evaluation-of-masticatory-function-a-preliminary-study
#8
Aline Pedroni-Pereira, Maria Carolina Salomé Marquezin, Darlle Santos Araujo, Luciano José Pereira, Silvana Bommarito, Paula Midori Castelo
The evaluation of mastication is important to understand the masticatory behavior and diagnose feeding difficulties. The objective of this preliminary study was to verify if there is agreement between objective and subjective validated methods of chewing evaluation in a convenience sample which consisted of 32 adolescents (mean 15.5years), complete permanent dentition and free of tooth decay. The Quality of Masticatory Function Questionnaire with the Food-Mastication, Habits, Meat, Fruit and Vegetables domains was used in the subjective evaluation...
December 4, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/29216382/improving-crispr-cas-specificity-with-chemical-modifications-in-single-guide-rnas
#9
Daniel E Ryan, David Taussig, Israel Steinfeld, Smruti M Phadnis, Benjamin D Lunstad, Madhurima Singh, Xuan Vuong, Kenji D Okochi, Ryan McCaffrey, Magdalena Olesiak, Subhadeep Roy, Chong Wing Yung, Bo Curry, Jeffrey R Sampson, Laurakay Bruhn, Douglas J Dellinger
CRISPR systems have emerged as transformative tools for altering genomes in living cells with unprecedented ease, inspiring keen interest in increasing their specificity for perfectly matched targets. We have developed a novel approach for improving specificity by incorporating chemical modifications in guide RNAs (gRNAs) at specific sites in their DNA recognition sequence ('guide sequence') and systematically evaluating their on-target and off-target activities in biochemical DNA cleavage assays and cell-based assays...
December 4, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29214860/a-comparison-of-unidimensionality-and-measurement-precision-of-the-narcissistic-personality-inventory-and-the-narcissistic-admiration-and-rivalry-questionnaire
#10
Michael P Grosz, Wilco H M Emons, Eunike Wetzel, Marius Leckelt, William J Chopik, Norman Rose, Mitja D Back
The current study compares the closeness to unidimensionality (CU) and measurement precision (MP) of the Narcissistic Personality Inventory (NPI)-with either a pairwise forced-choice or 5-point Likert-type scale response format-to the Narcissistic Admiration and Rivalry Questionnaire (NARQ). Minimum rank factor analysis and item information curves from item response models were utilized. The results mainly confirmed our expectations that NPI subscales are lower in CU and MP compared with NARQ subscales when the NPI was administered with its traditional forced-choice response format...
February 1, 2017: Assessment
https://www.readbyqxmd.com/read/29211932/targeted-versus-systematic-robot-assisted-transperineal-mri-trus-fusion-prostate-biopsy
#11
J Mischinger, S Kaufmann, G I Russo, N Harland, S Rausch, B Amend, M Scharpf, L Loewe, T Todenhoefer, M Notohamiprodjo, K Nikolaou, A Stenzl, J Bedke, S Kruck
OBJECTIVES: To evaluate the performance of transperineal robot-assisted (RA) targeted (TB) and systematic (SB) prostate biopsy in the primary and repeat biopsy setting. PATIENTS AND METHODS: Patients were admitted to RA biopsy between 2014-2016. Prior to RA-TB, multiparametric (mp) Magnetic Resonance Imaging (MRI) was performed. Prostate lesions were scored (Prostate Imaging, Reporting and Data System Version 2) and used for RA-TB planning. In addition, RA-SB was performed...
December 6, 2017: BJU International
https://www.readbyqxmd.com/read/29211281/effect-of-fluoride-dentifrice-and-casein-phosphopeptide-amorphous-calcium-phosphate-cream-with-and-without-fluoride-in-preventing-enamel-demineralization-in-a-ph-cyclic-study
#12
Priscila de Pinto Sinfiteli, Thereza Christina Lopes Coutinho, Patrícia Regina Almeida de Oliveira, Wesley Felisberto Vasques, Leandra Matos Azevedo, André Maues Brabo Pereira, Monica Almeida Tostes
OBJECTIVE: Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) complexes are anticariogenic and capable of remineralizing the early stages of enamel lesions. The use of fluoride prevents dental decay and the association of CPP-ACP with fluoride can increase remineralization. To evaluate the effect of CPP-ACP and CPP-ACPF creams associated with a fluoride dentifrice to prevent enamel demineralization in a pH cyclic model. MATERIAL AND METHODS: Previously selected by surface microhardness (SH) analysis, human enamel blocks (n = 56) were submitted to daily treatment with dentifrice in a pH-cycling model...
November 2017: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/29211120/cell-derived-microparticles-in-gingival-crevicular-fluid-from-periodontitis-patients-with-type-2-diabetes
#13
Carlos Marcelo Figueredo, Ronaldo Lira, Manuela Rubim Sete, Ricardo Guimarães Fischer
Cell-derived microparticles (MPs) have been described as vital contributors to the inflammatory process. However, its role in the periodontal disease pathogenesis remains unclear. Therefore, we aimed to detect the presence neutrophil (CD66b+) and platelet (CD41b+) derived microparticles in gingival crevicular fluid from individuals having periodontitis aggravated by type 2 diabetes. Twelve patients (56.2 ±7.2 yrs) with severe form of chronic periodontitis aggravated by type 2 diabetes were included. Clinical and metabolic data were gathered...
November 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/29210075/noise-contamination-from-pet-blood-sampling-pump-effects-on-structural-mri-image-quality-in-simultaneous-pet-mr-studies
#14
Elizabeth Bartlett, Christine DeLorenzo, Ramin Parsey, Chuan Huang
PURPOSE: To fully quantify PET imaging outcome measures, a blood-sampling pump is often used during the PET acquisition. With simultaneous PET/MR studies, a structural magnetization-prepared rapid gradient-echo (MP-RAGE) may also be acquired while the pump is generating electromagnetic noise. This study investigated whether this noise contamination would be detrimental to the quantification of volume and cortical thickness measures obtained from automated segmentation of the MP-RAGE image...
December 6, 2017: Medical Physics
https://www.readbyqxmd.com/read/29208618/feasibility-study-of-a-randomised-controlled-trial-to-investigate-the-treatment-of-sarcoidosis-associated-fatigue-with-methylphenidate-fast-mp-a-study-protocol
#15
Christopher Atkins, Richard Fordham, Allan B Clark, Andrea Stockl, Andrew P Jones, Andrew M Wilson
INTRODUCTION: Fatigue is a frequent and troublesome manifestation of chronic sarcoidosis. This symptom can be debilitating and difficult to treat, with poor response to the treatment. Symptomatic management with neurostimulants, such as methylphenidate, is a possible treatment option. The use of such treatment strategies is not without precedent and has been trialled in cancer-related fatigue. Their use in sarcoidosis requires further evaluation before it can be recommended for clinical practice...
December 4, 2017: BMJ Open
https://www.readbyqxmd.com/read/29206970/thrombospondin-1-and-disease-progression-in-dysferlinopathy
#16
Norifumi Urao, Rita E Mirza, Thomas F Corbiere, Zsuzsanna Hollander, Christoph H Borchers, Timothy J Koh
The purpose of this study was to determine whether thrombospondin (TSP)-1 promotes macrophage activity and disease progression in dysferlinopathy. First, we found that levels of TSP-1 are elevated in blood of non-ambulant dysferlinopathy patients compared with ambulant patients and healthy controls, supporting the idea that TSP-1 levels are correlated with disease progression. We then crossed dysferlinopathic BlaJ mice with TSP-1 knockout mice and assessed disease progression longitudinally with magnetic resonance imaging (MRI)...
December 15, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/29206755/the-oasis-mp-1-substudy-characterization-of-the-effect-of-ocriplasmin-on-microperimetry-parameters
#17
SriniVas R Sadda, Pravin U Dugel, Victor H Gonzalez, Esmeralda Meunier, Petra Kozma
PURPOSE: To evaluate the effects of ocriplasmin and symptomatic vitreomacular adhesion resolution on visual fixation and macular sensitivity using microperimetry. METHODS: MP-1 parameters were analyzed from 3 OASIS sites after the use of standardized instruments and testing procedures over 24 months. RESULTS: A total of 27 patients (19 ocriplasmin, 8 sham) were evaluated. Mean distance of the preferred fixation locus to the anatomical center was farther in the sham group at baseline and farther in the sham versus ocriplasmin group throughout the study...
December 4, 2017: Retina
https://www.readbyqxmd.com/read/29205439/influence-of-removable-prostheses-on-mastication-in-elderly-subjects-with-rheumatoid-arthritis-mastication-in-elders-with-rheumatoid-arthritis
#18
Kelly M Andrade, Bruna F M Alfenas, Renata C M Rodrigues Garcia
BACKGROUND: Rheumatoid arthritis (RA) is a prevalent disease in the elderly population, and it may affect the temporomandibular joint (TMJ) and the stomatognathic system OBJECTIVE: This study evaluated masticatory function in elderly patients with RA before and after oral rehabilitation with removable prostheses METHODS: Forty-five elders with partial or total edentulism who were using unsatisfactory removable prostheses were selected and assigned to three groups: RA with TMJ involvement, RA without TMJ involvement, and healthy controls...
December 4, 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/29204748/imaging-the-expression-of-glypican-3-in-hepatocellular-carcinoma-by-pet
#19
Zhen Wang, Yan-Jiang Han, Shun Huang, Meng Wang, Wen-Lan Zhou, Hong-Sheng Li, Quan-Shi Wang, Hu-Bing Wu
The glypican-3 (GPC3) receptor is overexpressed in hepatocellular carcinoma (HCC) and is a potential diagnostic and therapeutic target. GPC3-targeted molecular imaging will be helpful to differentiate diagnosis and guide therapy. In the present study, we will develop a novel PET probe for imaging the expression of GPC-3. L5 (sequence: RLNVGGTYFLTTRQ), a GPC3 targeting peptide, was labeled with 5-carboxyfluorescein (FAM) and 18F-fluoride. Cell binding tests were performed to identify the binding specificity of FAM-L5 and 18F radiolabeled peptide...
December 4, 2017: Amino Acids
https://www.readbyqxmd.com/read/29204584/anatomic-measures-of-upper-airway-structures-in-obstructive-sleep-apnea
#20
Jose E Barrera, Candace Y Pau, Veronique-Isabelle Forest, Andrew B Holbrook, Gerald R Popelka
Objective: Determine if anatomic dimensions of airway structures are associated with airway obstruction in obstructive sleep apnea (OSA) patients. Methods: Twenty-eight subjects with (n = 14) and without (n = 14) OSA as determined by clinical symptoms and sleep studies; volunteer sample. Skeletal and soft tissue dimensions were measured from radiocephalometry and magnetic resonance imaging. The soft palate thickness, mandibular plane-hyoid (MP-H) distance, posterior airway space (PAS) diameters and area, and tongue volume were calculated...
June 2017: World Journal of Otorhinolaryngology—Head and Neck Surgery
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