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https://www.readbyqxmd.com/read/29443045/routine-screening-method-for-microparticles-in-platelet-transfusions
#1
Daniel Millar, Larry Murphy, Audrey Labrie, Elisabeth Maurer-Spurej
Platelet inventory management based on screening microparticle content in platelet concentrates is a new quality improvement initiative for hospital blood banks. Cells fragment off microparticles (MP) when they are stressed. Blood and blood components may contain cellular fragments from a variety of cells, most notably from activated platelets. When performing their roles as innate immune cells and major players in coagulation and hemostasis, platelets change shape and generate microparticles. With dynamic light scattering (DLS)-based microparticle detection, it is possible to differentiate activated (high microparticle) from non-activated (low microparticle) platelets in transfusions, and optimize the use of this scarce blood product...
January 31, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29441963/do-patients-with-diabetes-type-2-or-chronic-heart-failure-understand-a-medication-plan
#2
L Botermann, A Wachter, K Monzel, K Krueger, S Ewen, F Mahfoud, N Griese-Mammen, M Schulz, U Laufs
A standardized medication plan (MP) was recently enacted into German law (§ 31a SGB V). The purpose of our study was to assess if patients with chronic diseases requiring polymedication understand the standardized MP and can transfer the given information into practice. 100 patients who took at least five medicines regularly were prospectively included in a cross-sectional study: 50 patients with the primary diagnosis chronic heart failure (CHF), and 50 with diabetes mellitus type 2 (DMT2). We performed a structured test-scenario studying the handling of a provided MP then evaluated the execution of the information on the MP by filling pill boxes and requested patients' opinion...
December 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29441579/brain-anatomy-of-the-4-day-old-european-rabbit
#3
Nanette Y Schneider, Frédérique Datiche, Gérard Coureaud
The European rabbit (Oryctolagus cuniculus) is a widely used model in fundamental, medical and veterinary neurosciences. Besides investigations in adults, rabbit pups are relevant to study perinatal neurodevelopment and early behaviour. To date, the rabbit is also the only species in which a pheromone - the mammary pheromone (MP) - emitted by lactating females and active on neonatal adaptation has been described. The MP is crucial since it contributes directly to nipple localisation and oral seizing in neonates, i...
February 14, 2018: Journal of Anatomy
https://www.readbyqxmd.com/read/29439495/active-electro-location-of-objects-in-the-underwater-environment-based-on-the-mixed-polarization-multiple-signal-classification-algorithm
#4
Yidong Xu, Wenjing Shang, Lili Guo, Junwei Qi, Yingsong Li, Wei Xue
This article proposes a novel active localization method based on the mixed polarization multiple signal classification (MP-MUSIC) algorithm for positioning a metal target or an insulator target in the underwater environment by using a uniform circular antenna (UCA). The boundary element method (BEM) is introduced to analyze the boundary of the target by use of a matrix equation. In this method, an electric dipole source as a part of the locating system is set perpendicularly to the plane of the UCA. As a result, the UCA can only receive the induction field of the target...
February 11, 2018: Sensors
https://www.readbyqxmd.com/read/29439089/yellow-577-nm-micropulse-laser-versus-half-dose-verteporfin-photodynamic-therapy-in-eyes-with-chronic-central-serous-chorioretinopathy-results-of-the-pan-american-collaborative-retina-study-pacores-group
#5
Jose A Roca, Lihteh Wu, Jans Fromow-Guerra, Francisco J Rodríguez, Maria H Berrocal, Sergio Rojas, Luiz H Lima, Roberto Gallego-Pinazo, Jay Chhablani, J Fernando Arevalo, David Lozano-Rechy, Martin Serrano
PURPOSE: To compare the functional and anatomical outcomes of eyes with chronic central serous chorioretinopathy treated with yellow micropulse (MP) laser versus half-dose verteporfin photodynamic therapy (PDT). METHODS: This is a multicentre, retrospective comparative study of 92 eyes treated with yellow MP laser (duty cycle of 5%, zero spacing between spots, spot size varied from 100 to 200 µm, power varied from 320 to 660 mW, and the pulse burst duration was 200 ms) and 67 eyes treated with PDT (half-dose verteporfin (3 mg/m 2 ) infused over 10 min), followed by laser activation for 83 s...
February 8, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29437268/using-support-vector-machine-analysis-to-assess-partinmr-a-new-prediction-model-for-organ-confined-prostate-cancer
#6
Jing Wang, Chen-Jiang Wu, Mei-Ling Bao, Jing Zhang, Hai-Bin Shi, Yu-Dong Zhang
BACKGROUND: Partin tables represent the most widely used predictive tool for prostate cancer stage at prostatectomy but with potential limitations. PURPOSE: To develop a new PartinMR model for organ-confined prostate cancer (OCPCA) by incorporating Partin table and mp-MRI with a support vector machine (SVM) analysis. STUDY TYPE: Retrospective. POPULATION: In all, 541 patients with biopsy-confirmed prostate cancer underwent mp-MRI...
February 13, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29435202/podocyte-derived-microparticles-promote-proximal-tubule-fibrotic-signaling-via-p38-mapk-and-cd36
#7
Mercedes N Munkonda, Shareef Akbari, Chloe Landry, Suzy Sun, Fengxia Xiao, Maddison Turner, Chet E Holterman, Rania Nasrallah, Richard L Hébert, Christopher R J Kennedy, Dylan Burger
Tubulointerstitial fibrosis is a hallmark of advanced diabetic kidney disease that is linked to a decline in renal function, however the pathogenic mechanisms are poorly understood. Microparticles (MPs) are 100-1000 nm vesicles shed from injured cells that are implicated in intercellular signalling. Our lab recently observed the formation of MPs from podocytes and their release into urine of animal models of type 1 and 2 diabetes and in humans with type 1 diabetes. The purpose of the present study was to examine the role of podocyte MPs in tubular epithelial cell fibrotic responses...
2018: Journal of Extracellular Vesicles
https://www.readbyqxmd.com/read/29433839/an-accurate-emotion-recognition-system-using-ecg-and-gsr-signals-and-matching-pursuit-method
#8
Atefeh Goshvarpour, Ataollah Abbasi, Ateke Goshvarpour
BACKGROUND: The purpose of the current study was to examine the effectiveness of Matching Pursuit (MP) algorithm in emotion recognition. METHODS: Electrocardiogram (ECG) and galvanic skin responses (GSR) of 11 healthy students were collected while subjects were listening to emotional music clips. Applying three dictionaries, including two wavelet packet dictionaries (Coiflet, and Daubechies) and discrete cosine transform, MP coefficients were extracted from ECG and GSR signals...
December 2017: Biomedical Journal
https://www.readbyqxmd.com/read/29433278/interactions-and-phase-behaviors-in-mixed-solutions-of-%C3%AE%C2%BA-carrageenan-and-myofibrillar-protein-extracted-from-alaska-pollock-surimi
#9
Tao Zhang, Xiaoqi Xu, Zhaojie Li, Yuming Wang, Yong Xue, Changhu Xue
In the present work, we provide insight into electrostatic interactions and phase behaviors in mixtures of myofibrillar protein (MP) and κ-carrageenan (KC) of various pHs (8.0-3.0) and biopolymer weight ratios [R, from 1:1 to 20:1; total concentration=0.05% (w/w)] through turbidimetric analysis, dynamic light scattering (DLS) and zeta potential analysis, and optical microscopy. At R=1: 1, critical pH values (i.e., pHc, pHΦ1, and pHΦ2), which indicate phase transitions interrelated to the formation of soluble or insoluble MP-KC complexes, were observed at pH7...
March 2018: Food Research International
https://www.readbyqxmd.com/read/29431710/effect-of-salinity-on-medium-and-low-pressure-uv-disinfection-of-vibrio-cholerae
#10
P Y Chen, X N Chu, L Liu, J Y Hu
The problem of biological invasions attributed to ballast water release is an ongoing problem that threatens ecosystems and human health. Ultraviolet (UV) radiation has been increasingly used for ballast water treatment mainly due to the advantages of short contact time and minimized harmful disinfection by products. In this study, the impact of salinity on the inactivation of Vibrio cholerae (NCTC 7253) was examined, and comparison of inactivation level and disinfection kinetics after medium-pressure (MP) (1 kW) and low-pressure (LP) (10 W) UV irradiation was made...
February 2018: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/29430091/endodontic-treatment-of-chronically-infected-primary-teeth-using-triple-antibiotic-paste-an-in-vivo-study
#11
G Anuradha Reddy, E Sridevi, A J Sai Sankar, K Pranitha, M J S Pratap Gowd, C Vinay
Aim: Maintenance of primary dentition is imperative for the development of arch form, esthetics, function, mastication, and normal eruption of permanent teeth. Premature loss can cause various problems such as ectopic eruption, space loss for the successor permanent teeth, alterations in speech, and impairment of function. Hence, decayed primary teeth should not be extracted and treated whenever possible. Pulpectomy is generally recommended as a treatment of choice in such cases. The purpose of this study was to evaluate the clinical and radiographic success of pulpectomized primary teeth with chronic infection using a mixture of metronidazole, ciprofloxacin, and minocycline (3MIX)-MP as an intracanal medicament before the obturation...
November 2017: Journal of Conservative Dentistry: JCD
https://www.readbyqxmd.com/read/29427634/mucuna-pruriens-l-dc-chemo-sensitize-human-breast-cancer-cells-via-downregulation-of-prolactin-mediated-jak2-stat5a-signaling
#12
Sonam Sinha, Sonal Sharma, Jaykant Vora, Heta Shah, Anshu Srivastava, Neeta Shrivastava
ETHNOPHARMACOLOGICAL RELEVANCE: Mucuna pruriens (L.) DC (MP) is an ancient Indian medicinal plant traditionally used to treat Parkinson's disease. L-Dopa (LD), precursor of dopamine is abundantly found in the seeds of MP. L-dopa is a natural inhibitor of prolactin (PRL) hormone which is required to maintain lactation in women but it's over production (hyperprolactinemia) plays critical role in advancement of breast cancer. AIM OF THE STUDY: We aim to examine the pharmacological effect of LD and MP on this hyperprolactinemia associated breast cancer and related signaling for effective management of the disease...
February 7, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29426212/monetary-valuation-of-salicylic-acid-methylparaben-and-thcooh-in-a-mediterranean-coastal-wetland-through-the-shadow-prices-methodology
#13
Águeda Bellver-Domingo, Ramón Fuentes, Francesc Hernández-Sancho, Eric Carmona, Yolanda Picó, Vicent Hernández-Chover
The presence of pharmaceutical and personal care products and drugs of abuse (PPCPs) in wastewater treatment plants (WWTPs) indicates discharge of the effluent may not be suitable for the ecological balance of water ecosystems, such as wetlands. These PPCPs degrade water quality, considered as an ecosystem service (ES), provoking serious environmental impacts. Assessing the monetary value of PPCPs can be used as a proxy for environmental status of the ES of water quality (ESWQ). Considering PPCPs as non-desirable outputs of WWTPs, the shadow prices methodology has been implemented using directional distance function to measure the environmental avoided cost of removing salicylic acid (SA), methylparaben (MP), and THCOOH from WWTPs effluents discharged to Albufera Natural Park (Spain)...
February 2, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29425904/onset-of-action-of-the-fixed-combination-intranasal-azelastine-fluticasone-propionate-in-an-allergen-exposure-chamber
#14
Jean Bousquet, Eli Meltzer, Peter Couroux, Arkady Koltun, Ferdinand Kopietz, Ullrich Munzel, Hans Christian Kuhl, Duc Tung Nguyen, Anne Marie Salapatek, David Price
BACKGROUND: A fixed-dose combination of intranasal azelastine hydrochloride-fluticasone propionate (MP-AzeFlu) is the most effective treatment of allergic rhinitis (AR), but its onset of action requires further investigation. OBJECTIVES: This study compared onset of action of MP-AzeFlu with the free combination of oral loratadine and intranasal fluticasone propionate (LORA/INFP). METHODS: In this single-center randomized, placebo-controlled, double-blind, double-dummy, three-period crossover trial, AR symptoms were induced in asymptomatic patients by ragweed pollen challenge in an allergen environmental exposure chamber...
February 6, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29423200/idiopathic-membranous-nephropathy-in-patients-with-diabetes-mellitus-a-diagnostic-and-therapeutic-quandary
#15
Dharmendra Bhadauria, Anand Chellappan, Anupma Kaul, Praveen Etta, Vinay Badri, Raj Kumar Sharma, Narayan Prasad, Amit Gupta, Manoj Jain
Background: Proteinuria and renal dysfunction is common in diabetic patients and may occur due to variety of causes. Nondiabetic renal diseases (NDRD) account for 30% of the renal biopsies, and idiopathic membranous nephropathy (iMN) is a common non diabetic glomerular disease that can exist alone or in combination with diabetic nephropathy (DN). Immunosuppressants used in iMN may be associated with complications of worsening glycemic control and recurrent infections. There is a paucity of literature on the clinical course, outcomes and treatment adverse effects of patients with iMN and diabetes...
February 2018: Clinical Kidney Journal
https://www.readbyqxmd.com/read/29420978/multiparametric-mr-imaging-of-the-prostate-interpretation-including-prostate-imaging-reporting-and-data-system-version-2
#16
REVIEW
Alessandro Furlan, Amir A Borhani, Antonio C Westphalen
mp-MRI of the prostate is a complex study that combines anatomic and functional imaging. The complexity of this technique, along with an increasing demand, has brought new challenges to imaging interpretation. The Prostate Imaging Reporting and Data System provides radiologists with guidelines to standardize interpretation. This article discusses the interpretation of the pulse sequences recommended in the Prostate Imaging Reporting and Data System version 2 guidelines, reviews advanced quantitative imaging tools, and discusses future directions...
March 2018: Radiologic Clinics of North America
https://www.readbyqxmd.com/read/29417898/food-and-feeding-habits-of-gaur-bos-gaurus-in-highlands-of-central-india-a-case-study-at-pench-tiger-reserve-madhya-pradesh-india
#17
Abdul Haleem, Orus Ilyas
Indian gaur (Bos gaurus) is one of nine species of wild oxen found in the world. They are largely confined to evergreen, semi-evergreen, and moist deciduous forests, but also occur in dry deciduous forest areas at the periphery of their range. According to the IUCN Red List ( 2017 ), the estimated population of gaur in India is between 15,000 and 35,000 individuals, and probably due to this, despite the gaur's vast range of distribution, they are listed as a vulnerable species by IUCN and listed as schedule-I of the Indian Wildlife Protection Act ( 1972 ) as well as in appendix-I in CITES ( 2003 )...
February 2018: Zoological Science
https://www.readbyqxmd.com/read/29416770/hprt1-activity-loss-is-associated-with-resistance-to-thiopurine-in-all
#18
Fan Yang, Houshun Fang, Dan Wang, Yao Chen, Yonggong Zhai, Bin-Bing S Zhou, Hui Li
Acute lymphoblastic leukemia (ALL) is an aggressive hematological tumor resulting from the malignant transformation of lymphoid progenitors. Thiopurine is a widely used drug in the maintaining treatment of ALL. After a period of chemotherapy, 20% of pediatric patients and over 50% of adult patients will relapse. To investigate the mechanisms of drug resistance in vitro, we established the thiopurine resistant cell lines Reh-6MPR (6-MP Resistant cell) and Reh-6TGR (6-TG Resistant cell) by stepwise selection of the ALL cell line Reh...
January 5, 2018: Oncotarget
https://www.readbyqxmd.com/read/29415423/vitamin-e-phosphate-nucleoside-prodrugs-a-platform-for-intracellular-delivery-of-monophosphorylated-nucleosides
#19
Richard Daifuku, Michael Koratich, Murray Stackhouse
Vitamin E phosphate (VEP) nucleoside prodrugs are designed to bypass two mechanisms of tumor resistance to therapeutic nucleosides: nucleoside transport and kinase downregulation. Certain isoforms of vitamin E (VE) have shown activity against solid and hematologic tumors and result in chemosensitization. Because gemcitabine is one of the most common chemotherapeutics for the treatment of cancer, it was used to demonstrate the constructs utility. Four different VE isoforms were conjugated with gemcitabine at the 5' position...
February 6, 2018: Pharmaceuticals
https://www.readbyqxmd.com/read/29414865/development-of-an-effective-6-methylpurine-counterselection-marker-for-genetic-manipulation-in-thermococcus-barophilus
#20
Tiphaine Birien, Axel Thiel, Ghislaine Henneke, Didier Flament, Yann Moalic, Mohamed Jebbar
A gene disruption system for Thermococcus barophilus was developed using simvastatin (HMG-CoA reductase encoding gene) for positive selection and 5-Fluoroorotic acid (5-FOA), a pyrF gene for negative selection. Multiple gene mutants were constructed with this system, which offers the possibility of complementation in trans, but produces many false positives (<80%). To significantly reduce the rate of false positives, we used another counterselective marker, 6-methylpurine (6-MP), a toxic analog of adenine developed in Thermococcus kodakarensis, consistently correlated with the TK0664 gene (encoding a hypoxanthine-guanine phosphoribosyl-transferase)...
February 7, 2018: Genes
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