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Joachim Laun, Wouter Marchal, Vanessa Trouillet, Alexander Welle, An T Hardy, Marlies K Van Bael, Christopher Barner-Kowollik, Tanja Junkers
Efficient and simple polymer conjugation reactions are critical for introducing functionalities on surfaces. For polymer surface grafting, post polymerization modifications are often required, which can impose a significant synthetic hurdle. Here, we report two strategies that allow for reversible surface engineering via nitrone-mediated radical coupling (NMRC). Macroradicals stemming from activation of polymers generated by copper-mediated radical polymerization are grafted via radical trapping with a surface-immobilized nitrone or a solution-borne nitrone...
February 19, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Chung-Ying Lin, Mark D Griffiths, Amir H Pakpour
Background and aims Research examining problematic mobile phone use has increased markedly over the past 5 years and has been related to "no mobile phone phobia" (so-called nomophobia). The 20-item Nomophobia Questionnaire (NMP-Q) is the only instrument that assesses nomophobia with an underlying theoretical structure and robust psychometric testing. This study aimed to confirm the construct validity of the Persian NMP-Q using Rasch and confirmatory factor analysis (CFA) models. Methods After ensuring the linguistic validity, Rasch models were used to examine the unidimensionality of each Persian NMP-Q factor among 3,216 Iranian adolescents and CFAs were used to confirm its four-factor structure...
February 15, 2018: Journal of Behavioral Addictions
Federica Rigo, Nicola De Stefano, Victor Navarro-Tableros, Ezio David, Giorgia Rizza, Giorgia Catalano, Nicholas Gilbo, Francesca Maione, Federica Gonella, Dorotea Roggio, Silvia Martini, Damiano Patrono, Mauro Salizzoni, Giovanni Camussi, Renato Romagnoli
BACKGROUND: The gold standard for organ preservation before transplantation is static cold storage, which is unable to fully protect suboptimal livers from ischemia/reperfusion injury. An emerging alternative is normothermic machine perfusion (NMP), which permits organ reconditioning. Here, we aimed to explore the feasibility of a pharmacological intervention on isolated rat livers by using a combination of NMP and human liver stem cells-derived extracellular vesicles (HLSC-EV). METHODS: We established an ex vivo murine model of NMP capable to maintain liver function despite an ongoing hypoxic injury induced by hemodilution...
February 9, 2018: Transplantation
Louise de Swart, Alex Smith, Detlef Haase, Pierre Fenaux, Argiris Symeonidis, Jaroslav Cermak, Guillermo Sanz, Reinhard Stauder, Moshe Mittelman, Eva Hellström-Lindberg, Luca Malcovati, Saskia Langemeijer, Mette Skov-Holm, Krzysztof Mądry, Ulrich Germing, Antonio Medina Almeida, Aurelia Tatic, Aleksandar Savic, Njetočka Gredelj Šimec, Corine van Marrewijk, Agnes Guerci-Bresler, Laurence Sanhes, Elisa Luño, Dominic Culligan, Odile Beyne-Rauzy, Sonja Burgstaller, Nicole Blijlevens, David Bowen, Theo de Witte
Conventional karyotype is one of the most relevant prognostic factors in MDS. However, about 50% of patients with MDS have a normal karyotype. Usually, 20-25 normal metaphases (nMP) are considered to be optimal to exclude small abnormal clones which might be associated with poor prognosis. This study evaluated the impact of examining a suboptimal number of metaphases in patients recruited to the EUMDS Registry with low and intermediate-1 risk according to IPSS. Only 179/1049 (17%) of patients with a normal karyotype had a suboptimal number of nMP, defined as less than 20 metaphases analyzed...
January 31, 2018: Leukemia Research
Zhen Chen, Kuan Yang, Chengbin Huang, Alan Zhu, Lian Yu, Feng Qian
PURPOSE: To study the effects of physicochemical properties of drug and polymer, as well as the drug-polymer interactions, on the surface composition of SDDs. METHODS: Ethanol solutions containing a model drug (IMC, NMP or FCZ) and a model polymer (PVPK12, PVPK30 or PVP-VA) were spray dried, and the surface composition of SDDs was analyzed by XPS. The surface tensions of pure components and their solutions were measured using Wilhelmy plate and/or calculated using ACD/Labs...
January 29, 2018: Pharmaceutical Research
Yuqing Zheng, Qiang Cui
The open/close transition in adenylate kinase (AK) is regarded as a representative example for large-scale conformational transition in proteins, yet its mechanism remains unclear despite numerous experimental and computational studies. Using extensive ($\sim$50 $\mu s$) explicit solvent atomistic simulations and Markov state analysis, we shed new lights on the mechanism of this transition in the apo form of AK. The closed basin of apo AK features an open NMP domain while the LID domain closes and rotates toward it...
January 29, 2018: Journal of Chemical Theory and Computation
Yuri L Boteon, Richard Laing, Hynek Mergental, Gary M Reynolds, Darius F Mirza, Simon C Afford, Ricky H Bhogal
Ischaemia-reperfusion injury (IRI) is the leading cause of injury seen in the liver following transplantation. IRI also causes injury following liver surgery and haemodynamic shock. The first cells within the liver to be injured by IRI are the liver sinusoidal endothelial cells (LSEC). Recent evidence suggests that LSEC co-ordinate and regulates the livers response to a variety of injuries. It is becoming increasingly apparent that the cyto-protective cellular process of autophagy is a key regulator of IRI...
December 28, 2017: World Journal of Gastroenterology: WJG
Mohammad Adawi, Nicola Luigi Bragazzi, Lidia Argumosa-Villar, Joan Boada-Grau, Andreu Vigil-Colet, Caglar Yildirim, Giovanni Del Puente, Abdulla Watad
BACKGROUND: Nomophobia, which is a neologism derived from the combination of "no mobile," "phone," and "phobia" is considered to be a modern situational phobia and indicates a fear of feeling disconnected. OBJECTIVE: No psychometric scales are available in Italian for investigating such a construct. We therefore planned a translation and validation study of the Nomophobia Questionnaire (NMP-Q), which is an instrument developed by Yildirim and Correia. Subjects were recruited via an online survey using a snowball approach...
January 22, 2018: JMIR MHealth and UHealth
Silvestre Bongiovanni Abel, Edith Inés Yslas, Claudia Rosana Rivarola, Cesar Alfredo Barbero
Polyaniline nanoparticles (PANI-NPs) were easily obtained applying the solvent displacement method by using N-methylpyrrolidone (NMP) as good solvent and water as poor solvent. Different polymers such as polyvinylpyrrolidone (PVP), chondroitin sulfate (ChS), polyvinyl alcohol (PVA), and polyacrylic acid (PAA) were used as stabilizers. Dynamic Light Scattering and Scanning Electron Microscopy corroborated the size and morphology of the formed NPs. It was demonstrated that the size of nanoparticles could controlled by setting the concentration of PANI in NMP, the NMP to water ratio, and the stabilizer´s nature...
January 22, 2018: Nanotechnology
LiNa Wang, Xiao Zheng, Fei Wu, Lan Shen, Xiao Lin, Yi Feng
This work aimed to achieve long-lasting delivery of radix ophiopogonis polysaccharide (ROP) by sucrose acetate isobutyrate (SAIB)-based in situ forming systems (ISFSs) alone or combined with mono-PEGylation of ROP. When the '90%SAIB/10% solvent' system was used, the mean residence time (MRT) of ROP was prolonged by 4.3 5 ∼ 7.00 times and the initial release rate was reduced significantly. However, this system was only suitable for days-long sustained release of ROP in short-term therapy. As to the 'SAIB/additives/solvent' system containing mono-PEGylated ROP, the results indicated that SAIB/poly(d,l-lactide-co-glycolide) (PLGA)/N-methyl-2-pyrrolidone (NMP) was superior to SAIB/polylactic acid (PLA)/NMP and SAIB/PLA/ethanol in controlled release...
November 2018: Drug Delivery
Yang-Tian Yan, Wen-Yan Zhang, Fang Zhang, Feng Cao, Rui-Feng Yang, Yao-Yu Wang, Lei Hou
Four new metal-organic frameworks (MOFs), {[Zn3(L)(OH)(H2O)5]·NMP·2H2O}n (1), {[H2N(Me)2][Zn2(L)(H2O)]·DMF·H2O}n (2), {[Co5(L)2(H2O)11]·2H2O}n (3) and {[Mn5(L)2(H2O)12]·6H2O}n (4), were assembled employing a symmetrical V-shaped rigid multicarboxylic acid ligand H5L (H5L = 2,4-di(3',5'-dicarboxylphenyl)benzoic acid) with different metal ions, resulting in versatile frameworks as well as various types of coordination modes of H5L. 1 forms a three-dimensional (3D) 4-connected sra net based on trinuclear [Zn3(μ3-OH)(μ2-COO)(μ1-COO)4] clusters, while 2 displays a 3D (4,6)-connected net based on two types of binuclear [Zn2(μ2-COO)2(μ1-COO)4] and [Zn2(μ2-COO)4] clusters...
January 12, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Kun Lu, Gang Rui, Fan Liu, Ling Yang, Xiaoling Deng, Songlin Shi, Qifu Li
The 14-3-3 protein family may regulates protein interaction, transportation and cellular localization. The regulatory role of 14-3-3ε is influenced by its altered localization. In the present study, human osteosarcoma MG-63 cells were treated with curcumin to induce apoptosis. Subsequently, the altered expression and localization of 14-3-3ε and its co-localization with other apoptosis-associated proteins during apoptosis was investigated. Analysis of nuclear matrix proteins (NMPs), using two-dimensional gel electrophoresis with matrix-assisted laser-desorption/ionization time-of-flight mass spectrometry, revealed that 14-3-3ε existed on the nuclear matrix of MG-63 cells, and its expression was decreased compared with that in control cells following curcumin treatment...
January 2018: Oncology Letters
Alix P M Matton, Laura C Burlage, Rianne van Rijn, Yvonne de Vries, Shanice A Karangwa, Maarten W Nijsten, Annette S H Gouw, Janneke Wiersema-Buist, Jelle Adelmeijer, Andrie C Westerkamp, Ton Lisman, Robert J Porte
BACKGROUND: Normothermic machine perfusion (NMP) enables viability assessment of donor livers prior to transplantation. NMP is frequently performed using human blood products including red blood cells (RBC) and fresh frozen plasma (FFP). Our aim was to examine the efficacy of a novel machine perfusion solution based on polymerized bovine hemoglobin HBOC-201. METHODS: Twenty-four livers declined for transplantation were transported using static cold storage. Upon arrival, livers underwent NMP for 6 hours using pressure-controlled portal and arterial perfusion...
December 27, 2017: Liver Transplantation
Chun Heng Loh, Bing Wu, Liya Ge, Chaozhi Pan, Rong Wang
N-methyl-2-pyrrolidone (NMP) is widely used as a solvent in polymeric membrane fabrication process, its elimination from the process wastewater (normally at a high concentration > 1000 mg/L) prior to discharge is essential because of environmental concern. This study investigated the feasibility of treating high-strength NMP-containing process wastewater in a sequencing batch reactor (SBR; i.e., batch feeding and intermittent aerobic/anoxic condition) and a membrane bioreactor (MBR; i.e., continuous feeding and aeration), respectively...
December 6, 2017: Chemosphere
Ahmer M Hameed, Ray Miraziz, David B Lu, Neil Warwick, Ali El-Ayoubi, Heather Burns, Yi Vee Chew, Ross Matthews, Greg O'Grady, Lawrence Yuen, Natasha Rogers, Henry C Pleass, Wayne J Hawthorne
BACKGROUND: The ongoing supply-demand gap with respect to donor kidneys for transplantation necessitates the increased use of higher kidney donor profile index and/or donation after circulatory death (DCD) kidneys. Machine perfusion (MP) preservation has become increasingly popular as a means to preserve such organs. Human data regarding normothermic kidney MP (NMP) is in its infancy, and such a system has not been established in the Australasian clinical setting. METHODS: Modified cardio-pulmonary bypass technology was utilized to develop a viable NMP kidney perfusion system using a porcine DCD model...
December 14, 2017: ANZ Journal of Surgery
Yujing Wang, Lee Makowski
Adenylate kinase (ADK) catalyzes the reversible Mg2+ -dependent phosphoryl transfer reaction Mg2+ +2ADP ↔Mg2+ +ATP + AMP in essential cellular systems. This reaction is a major player in cellular energy homeostasis and the isoform network of ADK plays an important role in AMP metabolic signaling circuits. ADK has three domains, the LID, NMP and CORE domains, that undergo large conformational rearrangements during ADK's catalytic cycle. In spite of extensive experimental and computational studies, details of the conformational pathway from open to closed forms remain uncertain...
December 14, 2017: Proteins
You-Hyun Seo, Eun-Chong Kim, Se-Phin Cho, Seok-Soon Kim, Seok-In Na
In this data article, we introduced the hysteresis of planar perovskite solar cells (PSCs) fabricated using dimethylformamide (DMF), gamma-butyrolactone (GBL), methyl-2-pyrrolidinone (NMP), dimethylsulfoxide (DMSO), DMF-DMSO, GBL-DMSO and NMP-DMSO as perovskite precursor solutions according to different scan directions, sweep times, and current stability. The hysteresis analyses of the planar PSCs prepared with a glass-ITO /NiOX/perovskite /PC61BM/BCP/Ag configuration were measured with Keithley 2400 source meter unit under 100 mW/cm2 (AM 1...
February 2018: Data in Brief
Yu Sun, Henrik Jensen, Nickolaj J Petersen, Susan W Larsen, Jesper Østergaard
For poly (lactide-co-glycolide acid) (PLGA)-based in situ forming implants, the rate of implant formation plays an important role in determining the overall drug release kinetics. Currently, in vitro techniques capable of characterizing the processes of drug release and implant formation at the same time are not available. A hydrogel-based in vitro experimental setup was recently developed requiring only microliter of formulation and forming a closed system potentially suitable for interfacing with various spectroscopic techniques...
December 2, 2017: Journal of Pharmaceutical and Biomedical Analysis
Md Mhahabubur Rhaman, Douglas R Powell, Md Alamgir Hossain
Understanding the intermolecular interactions between nucleotides and artificial receptors is crucial to understanding the role of nucleic acids in living systems. However, direct structural evidence showing precise interactions and bonding features of a nucleoside monophosphate (NMP) with a macrocycle-based synthetic molecule has not been provided so far. Herein, we present two novel crystal structures of uridine monophosphate (UMP) and thymidine monophosphate (TMP) complexes with a macrocycle-based dinuclear receptor...
November 30, 2017: ACS Omega
S A Hosgood, E Thompson, T Moore, C H Wilson, M L Nicholson
BACKGROUND: A significant proportion of donation after circulatory death (DCD) kidneys are declined for transplantation because of concerns over their quality. Ex vivo normothermic machine perfusion (NMP) provides a unique opportunity to assess the quality of a kidney and determine its suitability for transplantation. METHODS: In phase 1 of this study, declined human DCD kidneys underwent NMP assessment for 60 min. Kidneys were graded 1-5 using a quality assessment score (QAS) based on macroscopic perfusion, renal blood flow and urine output during NMP...
December 6, 2017: British Journal of Surgery
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