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https://www.readbyqxmd.com/read/29046144/purine-and-pyrimidine-phosphoribosytransferases-a-versatile-tool-for-enzymatic-synthesis-of-nucleoside-5-monophosphates
#1
J Del Arco, J Fernández-Lucas
BACKGROUND: In recent years, enzymatic methods have shown to be an efficient and sustainable alternative for the synthesis of nucleosides and nucleoside-5'-monophosphates (NMPs) to the traditional multistep chemical methods, since chemical glycosylation reactions include several protection-deprotection steps and the use of chemical reagents and organic solvents that are expensive and environmentally harmful. RESULTS: In this mini-review, we want to illustrate the application of phosphoribosyltransferases (PRTs) in enzymatic synthesis of NMPs...
October 17, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29039933/porous-uranium-diphosphonate-frameworks-with-trinuclear-units-templated-by-organic-ammonium-hydrolyzed-from-amine-solvents
#2
Zhi-Hui Zhang, Ganna A Senchyk, Yi Liu, Tyler Spano-Franco, Jennifer E S Szymanowski, Peter C Burns
By varying solvent systems, the solvothermal treatment of uranyl nitrate and methylenediphosphonic acid (H4PCP) afforded three new porous uranyl-organic frameworks (UOFs). All were structurally characterized by single-crystal X-ray diffraction and formulated as (Et2NH2)2[(UO2)3(PCP)2](H2O)2.5 (1), (MeNH3)(H3O)[(UO2)3(PCP)2(H2O)3] (2), and [Na(H2O)4](H3O)[(UO2)3(PCP)2(H2O)2](H2O)5 (3). These compounds crystallize with three-dimensional anionic frameworks containing U(VI) and distinct cationic species due to in situ solvent hydrolysis...
October 17, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29039797/dispersions-of-goethite-nanorods-in-aprotic-polar-solvents
#3
Delphine Coursault, Ivan Dozov, Christophe Blanc, Maurizio Nobili, Laurent Dupont, Corinne Chanéac, Patrick Davidson
Colloidal suspensions of anisotropic nanoparticles can spontaneously self-organize in liquid-crystalline phases beyond some concentration threshold. These phases often respond to electric and magnetic fields. At lower concentrations, usual isotropic liquids are observed but they can display very strong Kerr and Cotton-Mouton effects (i.e., field-induced particle orientation). For many examples of these colloidal suspensions, the solvent is water, which hinders most electro-optic applications. Here, for goethite (α-FeOOH) nanorod dispersions, we show that water can be replaced by polar aprotic solvents, such as N-methyl-2-pyrrolidone (NMP) and dimethylsulfoxide (DMSO), without loss of colloidal stability...
October 17, 2017: Materials
https://www.readbyqxmd.com/read/29037785/novel-bilayer-dissolving-microneedle-arrays-with-concentrated-plga-nano-microparticles-for-targeted-intradermal-delivery-proof-of-concept
#4
Lalit K Vora, Ryan F Donnelly, Eneko Larraneta, Patricia González-Vázquez, Raghu Raj Singh Thakur, Pradeep R Vavia
Polymeric microneedle (MN) arrays continue to receive growing attention due to their ability to bypass the skin's stratum corneum barrier in a minimally-invasive fashion and achieve enhanced transdermal drug delivery and "targeted" intradermal vaccine administration. In this research work, we fabricated biodegradable bilayer MN arrays containing nano - microparticles for targeted and sustained intradermal drug delivery. For this study, model drug (vitamin D3, VD3)-loaded PLGA nano- and microparticles (NMP) were prepared by a single emulsion solvent evaporation method with 72...
October 13, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29035286/urocytological-evaluation-of-pemphigus-patients-on-long-term-cyclophosphamide-therapy-a-cross-sectional-study
#5
Sujay Khandpur, Saurabh Singh, Saumyaranjan Mallick, Vinod Kumar Sharma, Venkat Iyer, Amlesh Seth, Mahesh Kumawat
BACKGROUND: Cyclophosphamide therapy is associated with several urological complications including urinary bladder malignancy. Data on urologic complications of chronic cyclophosphamide therapy for dermatologic conditions is not available. OBJECTIVES: To study the urocytological profile of pemphigus patients on long-term cyclophosphamide therapy. MATERIALS AND METHODS: In a cross-sectional study, consecutive patients who had received cyclophosphamide therapy for pemphigus for more than 12 months were included...
November 2017: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/29030443/a-novel-metabolic-pathway-for-n-methylpyrrolidone-degradation-in-alicycliphilus-sp-bq1
#6
Claudia Julieta Solís-González, Lilianha Domínguez-Malfavón, Martín Vargas-Suárez, Itzel Gaytán, Miguel Ángel Cevallos, Luis Lozano, M Javier Cruz-Gómez, Herminia Loza-Tavera
The molecular mechanisms underlying the biodegradation of N-Methylpyrrolidone (NMP), a widely used industrial solvent that produces skin irritation in humans, and is teratogenic in rats, are unknown. Alicycliphilus sp. BQ1 degrades NMP. By studying a transposon-tagged mutant unable to degrade NMP, we identified a six-gene cluster (nmpABCDEF), transcribed as a polycistronic mRNA, encoding enzymes involved in NMP biodegradation. nmpA and the transposon-affected gene nmpB encode a N-methylhydantoin amidohydrolase that would transform NMP to γ-N-methylaminobutyric acid; this would be metabolized by an aminoacid oxidase (NMPC), either by demethylation to produce γ-aminobutyric acid (GABA), or by deamination to produce succinate semialdehyde (SSA)...
October 13, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29024427/combined-liver-kidney-perfusion-enhances-protective-effects-of-normothermic-perfusion-on-livers-grafts-from-donation-after-cardiac-death
#7
Xiaoshun He, Fei Ji, Zhiheng Zhang, Yunhua Tang, Lu Yang, Shanzhou Huang, Wenwen Li, Qiao Su, Wei Xiong, Zebin Zhu, Linhe Wang, Lei Lv, Jiyou Yao, Linan Zhang, Longjuan Zhang, Zhiyong Guo
It has been showed that combined liver-kidney normothermic machine perfusion (NMP) is able to better maintain the circuit's biochemical milieu. Nevertheless, whether the combined perfusion is superior to liver perfusion alone in protecting livers from donation after cardiac death (DCD) is unclear. We aimed to test the hypothesis and explored the mechanisms. Livers from 15 DCD pig donors were subjected to either static cold storage group (Group A), liver alone NMP group (Group B), or combined liver-kidney NMP group (Group C)...
October 10, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/28991281/trombosis-venosa-espl%C3%A3-cnica-como-manifestaci%C3%A3-n-inicial-de-mielofibrosis-primaria
#8
Gregorio Campos-Cabrera, Virginia Campos-Cabrera, Salvador Campos-Cabrera, José-Luis Campos-Villagómez, Alejandra Romero-González
other: Las neoplasias mieloproliferativas (NMP) son alteraciones crónicas de las células madre hematopoyéticas clonales caracterizadas por una mayor producción de granulocitos, glóbulos rojos o plaquetas. Una de las principales complicaciones de las NMP es la aparición de problemas trombóticos venosos y arteriales causados por un aumento en la agregación plaquetaria y la generación de trombina. Se evaluaron 11 casos de mielofibrosis primaria (MP), de los cuales dos debutaron con trombosis venosa esplácnica (TVE)...
2017: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/28989533/trityl-based-alkoxyamines-as-nmp-controllers-and-spin-labels
#9
Gérard Audran, Elena G Bagryanskaya, Paul Brémond, Mariya V Edeleva, Sylvain R A Marque, Dmitriy A Parkhomenko, Olga Yu Rogozhnikova, Victor M Tormyshev, Evgeny V Tretyakov, Dmitry V Trukhin, Svetlana I Zhivetyeva
Recently, new applications of trityl-nitroxide biradicals were proposed. In the present study, attachment of a trityl radical to alkoxyamines was performed for the first time. The rate constants kd of C-ON bond homolysis in these alkoxyamines were measured and found to be equal to those for alkoxyamines without trityl. The electron paramagnetic resonance (EPR) spectra of the products of alkoxyamine homolysis (trityl-TEMPO and trityl-SG1 biradicals) were recorded, and the corresponding exchange interactions were estimated...
November 14, 2016: Polymer Chemistry
https://www.readbyqxmd.com/read/28986140/barriers-to-and-facilitators-of-independent-non-medical-prescribing-in-clinical-practice-a-mixed-methods-systematic-review
#10
Timothy Noblet, John Marriott, Emma Graham-Clarke, Alison Rushton
QUESTION: What are the factors that affect the implementation or utilisation of independent non-medical prescribing (iNMP)? DESIGN: Mixed-methods systematic review. Two reviewers independently completed searches, eligibility and quality assessments. DATA SOURCES: Pre-defined search terms were utilised to search electronic databases. Reference lists, key journals and grey literature were searched alongside consultation with authors/experts...
October 2017: Journal of Physiotherapy
https://www.readbyqxmd.com/read/28974009/pes-kaolin-mixed-matrix-membranes-for-arsenic-removal-from-water
#11
Tiziana Marino, Francesca Russo, Lina Rezzouk, Abderrazak Bouzid, Alberto Figoli
The aim of this work was the fabrication and the characterization of mixed matrix membranes (MMMs) for arsenic (As) removal from water. Membrane separation was combined with an adsorption process by incorporating the kaolin (KT2) Algerian natural clay in polymeric membranes. The effects of casting solution composition was explored using different amounts of polyethersufone (PES) as a polymer, polyvinyl-pyrrolidone (PVP K17) and polyethylene glycol (PEG 200) as pore former agents, N-methyl pyrrolidone (NMP) as a solvent, and kaolin...
September 30, 2017: Membranes
https://www.readbyqxmd.com/read/28961741/field-residues-and-effects-of-the-insect-growth-regulator-novaluron-and-its-major-co-formulant-n-methyl-2-pyrrolidone-on-honey-bee-reproduction-and-development
#12
Julia D Fine, Christopher A Mullin, Maryann T Frazier, Ryan D Reynolds
Owing to the recent declines in honey bee (Apis mellifera L.) populations, there is a need for field and laboratory studies to investigate threats to pollinator health. This study examines the hypothesis that the organophosphate alternative, Rimon 0.83EC, can have consequences to honey bee health by combining newly acquired field residue data, laboratory bioassays, and colony level feeding studies. Following label rate applications of Rimon 0.83EC to apple trees, average residue concentrations of the active ingredient, novaluron, were found to be 3...
September 1, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/28960870/side-chain-directed-dispersion-of-mos2-nanosheets-by-v-shaped-polyaromatic-compounds
#13
Atsushi Matsumoto, Keisuke Jono, Munetaka Akita, Michito Yoshizawa
Bulk molybdenum disulfide (MoS2) itself is virtually insoluble in common organic solvents because of the tight stacks of multiple MoS2 nanosheets. Here we report that V-shaped polyaromatic compounds with non-ionic side chains can efficiently exfoliate and disperse the inorganic nanosheets. Simple grinding and sonication (less than total 1 h) of MoS2 powder with the V-shaped compounds gave rise to large MoS2 nanosheets highly dispersed in NMP through efficient host-guest S-π and hydrophobic interactions. DLS and AFM analyses revealed that the lateral sizes (ca...
September 27, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28952726/understanding-differential-interaction-of-protic-and-aprotic-ionic-liquids-inside-molecular-confinement
#14
Somenath Panda, Kaushik Kundu, Akhil Pratap Singh, Sanjib Senapati, Ramesh L Gardas
Considering the contemporary interests of water-free reverse micelles (RMs) in the field of organic reaction medium and potential drug delivery carrier, we synthesized two different classes of ionic liquids (ILs), protic N-methyl-2-pyrrolidonium hexanoate, [NMP][Hex], and aprotic choline hexanoate, [Chl][Hex], and subsequently incorporated them in a mixture of polyoxyethylene (20) sorbitan monooleate (Tween-80) and cyclohexane. In order to understand the differential nature of interinterionic interaction of two ILs, we performed DFT calculations on pure ILs to correlate with experimental results...
October 6, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28951375/-value-of-neutrophil-monocyte-product-combined-with-serum-creatinine-in-assessing-the-severity-of-acute-pancreatitis
#15
Jiang Liu, Yang Bai, Aziguli Aziguli, Ya-Li Zhang
OBJECTIVE: To investigate the value of neutrophil-monocyte product (NMP) combined with serum creatinine (Scr) in the assessment of the severity of acute pancreatitis (AP). METHODS: The clinical data of 120 Uighur patients with AP were retrospectively analyzed, including 104 with non-severe AP (non-SAP group) and 16 with severe AP (SAP group). The correlation of NMP combined with Scr with ICU admission and in-hospital death were analyzed. The receiver operating characteristic (ROC) curves were plotted to compare the efficiency of acute physiology and chronic health evaluation (APACHE-II), neutrophil-lymphocyte ratio (NLR) and NMP combined with Scr in determining the severity of AP...
September 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28950499/using-missing-ordinal-patterns-to-detect-nonlinearity-in-time-series-data
#16
Christopher W Kulp, Luciano Zunino, Thomas Osborne, Brianna Zawadzki
The number of missing ordinal patterns (NMP) is the number of ordinal patterns that do not appear in a series after it has been symbolized using the Bandt and Pompe methodology. In this paper, the NMP is demonstrated as a test for nonlinearity using a surrogate framework in order to see if the NMP for a series is statistically different from the NMP of iterative amplitude adjusted Fourier transform (IAAFT) surrogates. It is found that the NMP works well as a test statistic for nonlinearity, even in the cases of very short time series...
August 2017: Physical Review. E
https://www.readbyqxmd.com/read/28942346/target-triggered-transcription-machinery-for-ultra-selective-and-sensitive-fluorescence-detection-of-nucleoside-triphosphates-in-one-minute
#17
Jiantong Dong, Tongbo Wu, Yu Xiao, Lu Chen, Lei Xu, Mengyuan Li, Meiping Zhao
Nucleoside triphosphates (NTPs) play important roles in living organisms. However, no fluorescent assays are currently available to simply and rapidly detect multiple NTPs with satisfactory selectivity, sensitivity and low cost. Here we demonstrate for the first time a target-triggered in-vitro transcription machinery for ultra-selective, sensitive and instant fluorescence detection of multiple NTPs. The machinery assembles RNA polymerase, DNA template and non-target NTPs to convert the target NTP into equivalent RNA signal sequences which are monitored by the fluorescence enhancement of molecular beacon...
September 19, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28933474/exfoliation-of-graphene-and-fluorographene-in-molecular-and-ionic-liquids
#18
Émilie Bordes, Joanna Szala-Bilnik, Agílio A H Pádua
We use molecular dynamics simulations to study the exfoliation of graphene and fluorographene in molecular and ionic liquids, by performing computer experiments in which one layer of the 2D nanomaterial is peeled from a stack, in vacuum and in the presence of solvent. The liquid media and the nanomaterials are represented by fully flexible, atomistic force fields. From these simulations we calculate the potential of mean force, or reversible work, required to exfoliate the materials. Calculations in water and organic liquids showed that small amides (NMP, DMF) are among the best solvents for exfoliation, in agreement with the experiment...
September 21, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28928304/nomophobic-behaviors-among-smartphone-using-medical-and-engineering-students-in-two-colleges-of-west-bengal
#19
Pallabi Dasgupta, Sharmistha Bhattacherjee, Samir Dasgupta, Jayanta Kumar Roy, Abhijit Mukherjee, Romy Biswas
BACKGROUND: Growing smartphone usage among global and Indian college students has resulted in considerable issues of "nomophobia" (NMP) or feelings of discomfort or anxiety experienced by individuals whenever unable to use their smartphones. This significantly impacts their health, work, and study. OBJECTIVE: The objective of this study is to find out the prevalence of NMP among smartphone using medical and engineering undergraduates of West Bengal and to compare the nomophobic behaviors, its predictors, and smartphone usage among them...
July 2017: Indian Journal of Public Health
https://www.readbyqxmd.com/read/28901972/normothermic-machine-perfusion-of-the-kidney
#20
Annemarie Weissenbacher, James Hunter
PURPOSE OF REVIEW: Normothermic machine perfusion (NMP) is a preservation method that is generating increasing interest. The aim of this review is to summarise the current status of NMP in regards of kidney viability assessment, reducing organ damage and improving transplant logistics. RECENT FINDINGS: The results of recent large animal experiments and clinical trials show that continuous prolonged normothermic ex-vivo kidney perfusion appears better than a brief period of NMP after static cold storage in terms of renal injury and function...
September 28, 2017: Current Opinion in Organ Transplantation
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