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https://www.readbyqxmd.com/read/28724014/prescription-medication-by-physiotherapists-a-brazilian-view-of-the-united-kingdom-canada-australia-and-new-zealand
#1
Valton da Silva Costa
Many health systems (HS) have adopted novel models of care which have included non-medical prescription (NMP) by physiotherapists. The aim of this study was to verify in the literature the existence of this practice and its possible benefits. A literature review was carried out through search on Science Direct, PubMed, SciELO, Lilacs and Google Scholar, and in the World Confederation for Physical Therapy and Chartered Society of Physiotherapy websites. In recent decades the United Kingdom adopted the NMP for health professionals, followed by Canada...
July 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28709939/transdermal-delivery-of-dimethyl-fumarate-for-alzheimer-s-disease-effect-of-penetration-enhancers
#2
Dina Ameen, Bozena Michniak-Kohn
Dimethyl fumarate (DMF) is an orally administered drug with neuroprotective and immunomodulatory activities. It has potential uses in the treatment of neurodegenerative diseases such as Alzheimer's disease (AD). The objective of this study was to investigate the feasibility of transdermal delivery of DMF by studying the effect of different penetration enhancers on the skin permeation of DMF. The permeation of saturated DMF solutions was investigated in propylene glycol (PG) with varying concentrations of each of the following enhancers: Polysorbate 80 (T80), N-methyl pyrrolidone (NMP), laurocapram (Azone(®)) (Az), Transcutol P (Tc), Terpineol (Terp), and cineole (Cin) using vertical Franz diffusion cells and human cadaver skin...
July 12, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28690260/rapid-quantification-of-n-methyl-2-pyrrolidone-in-polymer-matrices-by-thermal-desorption-gc-ms
#3
Young-Min Kim, Jae Woo Kim, Hye Mi Moon, Min-Jin Lee, Akihiko Hosaka, Atsushi Watanabe, Norio Teramae, Young-Kwon Park, Seung-Woon Myung
Analysis of a residual solvent in polymeric materials has become an important issue due to the increased regulations and standards for its use. N-Methyl-2-pyrrolidone (NMP) is a solvent widely used in many industries and restricted as one of the chemicals under EU REACH regulations due to its potential harmful effects. In this study, thermal desorption-gas chromatography/mass spectrometry (TD-GC/MS) is applied for the quantitative analysis of NMP with the use of a polymer-coated sample cup. By using the polymer-coated sample cup, the vaporization of NMP was prevented during waiting time before TD-GC/MS analysis...
2017: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/28680881/bone-regeneration-using-n-methyl-2-pyrrolidone-as-an-enhancer-for-recombinant-human-bone-morphogenetic-protein-2-in-a-rabbit-sinus-augmentation-model
#4
Hyun-Chang Lim, Daniel S Thoma, So-Ra Yoon, Jae-Kook Cha, Jung-Seok Lee, Ui-Won Jung
The aim of this study was to determine whether N-methyl-2-pyrrolidone (NMP) can decrease the dose of recombinant human bone morphogenetic protein-2 (rhBMP-2) in sinus augmentation of rabbits. In each of 15 rabbits, 2 sinuses were randomly grafted using 1 of 3 treatment modalities: (i) biphasic calcium phosphate (BCP; control), (ii) rhBMP-2-coated BCP (BMP), or (iii) rhBMP-2-coated BCP soaked in NMP solution (BMP/NMP). The rabbits were sacrificed 2 weeks postoperatively. Histologic and histomorphometric analyses were performed...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28675296/restoring-the-electrical-properties-of-cvd-graphene-via-physisorption-of-molecular-adsorbates
#5
Kishan Thodkar, Damien Thompson, Felix Lüönd, Lucas Moser, Frédéric Overney, Laurent Marot, Christian Schönenberger, Blaise Jeanneret, Michel Calame
Chemical vapor deposition (CVD) is a powerful technique to produce graphene for large-scale applications. Polymer-assisted wet transfer is commonly used to move the graphene onto silicon substrates, but the resulting devices tend to exhibit p-doping, which decreases the device quality and reproducibility. In an effort to better understand the origin of this effect, we coated graphene with n-methyl-2-pyrrolidone (NMP) and hexamethyldisilazane (HMDS) molecules that exhibit negligible charge transfer to graphene but bind more strongly to graphene than ambient adsorbents...
July 14, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28661648/graphene-fiber-based-supercapacitors-favor-n-methyl-2-pyrrolidone-ethyl-acetate-as-the-spinning-solvent-coagulant-combination
#6
Nanfei He, Qin Pan, Yixin Liu, Wei Gao
One-dimensional flexible fiber supercapacitors (FSCs) have attracted great interest as promising energy-storage units that can be seamlessly incorporated into textiles via weaving, knitting, or braiding. The major challenges in this field are to develop tougher and more efficient FSCs with a relatively easy and scalable process. Here, we demonstrate a wet-spinning process to produce graphene oxide (GO) fibers from GO dispersions in N-methyl-2-pyrrolidone (NMP), with ethyl acetate as the coagulant. Upon chemical reduction of GO, the resulting NMP-based reduced GO (rGO) fibers (rGO@NMP-Fs) are twice as high in the surface area and toughness but comparable in tensile strength and conductivity as that of the water-based rGO fibers (rGO@H2O-Fs)...
July 14, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28656743/sandwiched-thin-film-anode-of-chemically-bonded-black-phosphorus-graphene-hybrid-for-lithium-ion-battery
#7
Hanwen Liu, Yuqin Zou, Li Tao, Zhaoling Ma, Dongdong Liu, Peng Zhou, Hongbo Liu, Shuangyin Wang
A facile vacuum filtration method is applied for the first time to construct sandwich-structure anode. Two layers of graphene stacks sandwich a composite of black phosphorus (BP), which not only protect BP from quickly degenerating but also serve as current collector instead of copper foil. The BP composite, reduced graphene oxide coated on BP via chemical bonding, is simply synthesized by solvothermal reaction at 140 °C. The sandwiched film anode used for lithium-ion battery exhibits reversible capacities of 1401 mAh g(-1) during the 200th cycle at current density of 100 mA g(-1) indicating superior cycle performance...
June 28, 2017: Small
https://www.readbyqxmd.com/read/28648057/magnetic-anisotropy-along-a-series-of-lanthanide-polyoxometalates-with-pentagonal-bipyramidal-symmetry
#8
Jing Li, Chen Yuan, Li Yang, Ming Kong, Jing Zhang, Jing-Yuan Ge, Yi-Quan Zhang, You Song
Magneto-structural correlations in a series of lanthanide polyoxometalates (POMs) with pentagonal bipyramidal symmetry, namely, [Ln2(NMP)12(PW12O40)][PW12O40] (NMP is N-methyl pyrrolidone), were studied in detail experimentally combined with theoretical calculations. Furthermore, two types of Dy-based complexes with pentagonal bipyramidal symmetry were built to discuss the dependence of the theoretical energy barriers with the axial Dy-O bond lengths when the magnetic axes in ground Kramers doublet are along the axial orientation or on the equatorial plane...
July 17, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28630495/the-solution-plasma-process-for-heteroatom-carbon-nanosheets-the-role-of-precursors
#9
Koangyong Hyun, Nagahiro Saito
The solution plasma process (SPP), known as non-equilibrium cold plasma at atmospheric pressure and room temperature, was used to investigate the synthesis of nitrogen-carbon nasnosheets (NCNs). To verify the effect of elementary composition and structure of N-methyl-2-pyrrolidone (NMP), various precursors were used in the SPP to synthesize NCNs via the bottom-up synthesis method for the first time. The NCNs were analyzed by transmission electron microscopy, Raman spectroscopy, and X-ray photoelectron spectroscopy...
June 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28607668/future-perspectives-on-nonmedical-prescribing
#10
REVIEW
Derek Stewart, Tesnime Jebara, Scott Cunningham, Ahmed Awaisu, Abdulrouf Pallivalapila, Katie MacLure
Many countries have implemented nonmedical prescribing (NMP) and many others are scoping prescribing practices with a view to developing NMP. This paper provides a future perspective on NMP in light of findings of an umbrella review of aspects of NMP. This is followed by coverage of the Scottish Government strategy of pharmacist prescribing and finally, consideration of two key challenges. The review identified seven systematic reviews of influences on prescribing decision-making, processes of prescribing, and barriers and facilitators to implementation...
June 2017: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/28605989/sinus-floor-augmentation-comparing-an-in-situ-hardening-biphasic-calcium-phosphate-ha-%C3%AE-tcp-bone-graft-substitute-with-a-particulate-biphasic-calcium-phosphate-ha-%C3%AE-tcp-bone-graft-substitute-an-experimental-study-in-sheep
#11
Angelika Wildburger, Vladimir Bubalo, Marton Magyar, Heiner Nagursky, Norbert Jakse, Rainer Schmelzeisen, Sebastian Sauerbier
OBJECTIVE: The aim of the present split-mouth study in sheep was to assess the influence of in situ hardening properties of a biphasic calcium phosphate bone graft substitute (ratio HA/β-TCP = 60/40) compared to a particulate bone graft substitute with the same biphasic core-granule composition without in situ hardening properties on sinus floor augmentation. MATERIAL AND METHODS: Therefore, bilateral sinus floor augmentation was performed in eight sheep. PLGA coated, in situ hardening biphasic bone graft substitute (PLGA-NMP-BCP) was placed into the test site and a particulate biphasic bone graft substitute without PLGA coating (BCP) was used for the contralateral site as a control...
June 12, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28605412/accuracy-profiles-for-analyzing-residual-solvents-in-textiles-by-gc-ms
#12
Qibei Bao, Kejie Fu, Qingqing Ren, Yingying Zhong, Dan Qian
Excess residual solvents (RSs) in clothes or other textiles could be toxic and pose risks to both humans and the environment. N,N-Dimethylformamide (DMF), N,N-dimethylacetamide (DMAc) and 1-methyl-2-pyrrolidinone (NMP) are important chemicals frequently used as solvents in the textile industry. Several organizations have proposed limiting DMF, DMAc and NMP in textiles, but an appropriate detection method has not been proposed. A sensitive GC-MS method for the quantification of DMF, DMAc and NMP in textiles was developed...
June 9, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28594183/the-opposite-effect-of-water-and-n-methyl-2-pyrrolidone-cosolvents-on-the-nanostructural-organization-of-ethylammonium-butanoate-ionic-liquid-a-small-and-wide-angle-x-ray-scattering-and-molecular-dynamics-simulations-study
#13
Umme Salma, Natalia V Plechkova, Ruggero Caminiti, Lorenzo Gontrani
Two series of mixtures of ethylammoniumbutanoate (EAB, [N0 0 0 2][C3CO2]) in water and N-methyl-2-pyrrolidone (NMP) have been prepared at different molar fractions to assess the effect of these two polar solvents on the nanostructural order present in [N0 0 0 2][C3CO2]. The small- and wide-angle X-ray scattering (SWAXS) pattern of the liquid in neat state shows a prepeak at Q = 0.513 Å(-1), which is associated with the aggregation of nonpolar alkyl chains of both cations and anions. Interestingly, the two solvents affect the nanostructure of [N0 0 0 2][C3CO2] differently, though both are polar...
June 26, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28587232/fabrication-of-defect-free-cellulose-acetate-hollow-fibers-by-optimization-of-spinning-parameters
#14
Xuezhong He
Spinning of cellulose acetate (CA) with the additive polyvinylpyrrolidone (PVP) in N-methyl-2-pyrrolidone (NMP) solvent under different conditions was investigated. The spinning parameters of air gap, bore fluid composition, flow rate of bore fluid, and quench bath temperature were optimized based on the orthogonal experiment design (OED) method and multivariate analysis. FTIR and scanning electron microscopy were used to characterize the membrane structure and morphology. Based on the conjoint analysis in Statistical Product and Service Solutions (SPSS) software, the importance of these parameters was identified as: air gap > bore fluid composition > flow rate of bore fluid > quench bath temperature...
June 5, 2017: Membranes
https://www.readbyqxmd.com/read/28582606/2-2-6-6-tetramethylpiperydinyl-1-oxyl-tempo-functionalized-benzoxazines-prepared-with-a-one-pot-synthesis-for-reactive-crosslinkable-initiators-of-nitroxide-mediated-polymerization
#15
Yi-Jen Han, Ying-Ling Liu
In this work, the incorporation of a 2,2,6,6-tetramethylpiperydinyl-1-oxyl (TEMPO) group to a benzoxazine ring is performed using a one-pot synthesis for the preparation of TEMPO-functionalized benzoxazine compounds and polymers as reactive and crosslinkable initiators for nitroxide-mediated polymerization (NMP). The TEMPO-functionalization reaction of benzoxazine, traced with (1) H NMR, is conducted with sequential radical transfer and coupling reactions. Moreover, polystyrene-grafted polybenzoxazine copolymers are prepared with the TEMPO-benzoxazine initiator and NMP of styrene...
June 5, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/28537714/enhanced-afterglow-performance-of-persistent-luminescence-implants-for-efficient-repeatable-photodynamic-therapy
#16
Wenpei Fan, Nan Lu, Can Xu, Yijing Liu, Jing Lin, Sheng Wang, Zheyu Shen, Zhen Yang, Junle Qu, Tianfu Wang, Siping Chen, Peng Huang, Xiaoyuan Chen
Persistent luminescence nanoparticles (PLNPs) have been used for bioimaging without autofluorescence background interference, but the poor afterglow performance impedes their further applications in cancer therapy. To overcome the Achilles' heel of PLNPs, herein we report the construction of injectable persistent luminescence implants (denoted as PL implants) as a built-in excitation source for efficient repeatable photodynamic therapy (PDT). The injectable ZGC (ZnGa1.996O4:Cr0.004) PL implants were prepared by dissolving ZGC PLNPs in poly(lactic-co-glycolic acid)/N-methylpyrrolidone oleosol, which demonstrated much stronger persistent luminescence (PersL) intensity and longer PersL lifetime than that of ZGC PLNPs both in vitro and in vivo...
June 27, 2017: ACS Nano
https://www.readbyqxmd.com/read/28534835/emulsion-based-intradermal-delivery-of-melittin-in-rats
#17
Sang Mi Han, Se Gun Kim, Sok Cheon Pak
Bee venom (BV) has long been used as a traditional medicine. The aim of the present study was to formulate a BV emulsion with good rheological properties for dermal application and investigate the effect of formulation on the permeation of melittin through dermatomed rat skin. A formulated emulsion containing 1% (w/v) BV was prepared. The emulsion was compared with distilled water (DW) and 25% (w/v) N-methyl-2-pyrrolidone (NMP) in DW. Permeation of melittin from aqueous solution through the dermatomed murine skin was evaluated using the Franz diffusion cells...
May 19, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28530536/leuprolide-acetate-release-study-from-%C3%AE-irradiated-plga-based-in-situ-forming-system
#18
Mona Shapourgan, Hamid Mobedi, Nasrin Sheikh, Aliasghar Behnamghader, Arezou Mashak
It is well known that the properties of polymers can be altered by exposure to γ- ray. γ-irradiation has been used as a sterilization method for biodegradable polymeric drug delivery devices, and its drug release profile must not be significantly changed. In this study, the effect of γ-irradiation with 8 kGy doses on the release profile of leuprolide acetate from PLGA-based in situ forming system was evaluated. PLGA-based in situ forming systems were prepared by injecting some specific amount of irradiated solution of PLGA /NMP containing drug into a buffer phosphate pH 7...
March 28, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28520579/the-use-of-an-acellular-oxygen-carrier-in-a-human-liver-model-of-normothermic-machine-perfusion
#19
Richard W Laing, Ricky H Bhogal, Lorraine Wallace, Yuri Boteon, Desley A H Neil, Amanda Smith, Barney T F Stephenson, Andrea Schlegel, Stefan G Hübscher, Darius F Mirza, Simon C Afford, Hynek Mergental
BACKGROUND: Normothermic machine perfusion of the liver (NMP-L) is a novel technique that preserves liver grafts under near-physiological conditions whilst maintaining their normal metabolic activity. This process requires an adequate oxygen supply, typically delivered by packed red blood cells (RBC). We present the first experience using an acellular hemoglobin-based oxygen carrier (HBOC) Hemopure in a human model of NMP-L. METHODS: Five discarded high-risk human livers were perfused with HBOC-based perfusion fluid and matched to 5 RBC-perfused livers...
May 18, 2017: Transplantation
https://www.readbyqxmd.com/read/28490879/methodological-assessment-of-the-reduction-of-the-content-of-impurities-in-nimodipine-emulsion-via-the-use-of-21-amino-acid-protection
#20
Yiqiao Xie, Zhiquan Zhuang, Shu Zhang, Zihua Xia, De Chen, Kaiyan Fan, Jialin Ren, CuiCui Lin, Yanzhong Chen, Fan Yang
PURPOSE: The present study examined the factors affecting the content of impurities of nimodipine (NMP) emulsion and the associated methods of compound protection. METHODS: Destructive testing of NMP emulsion and its active pharmaceutical ingredient (API) were conducted, and ultracentrifugation was used to study the content of impurities in two phases. The impurity of NMP was measured under different potential of hydrogen (pH) conditions, antioxidants and pH-adjusting agents...
2017: International Journal of Nanomedicine
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