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Laboratory Medicine

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https://www.readbyqxmd.com/read/29045595/performance-of-apanteles-hemara-hymenoptera-braconidae-on-two-amaranth-leaf-webbers-spoladea-recurvalis-and-udea-ferrugalis-lepidoptera-crambidae
#1
S T O Othim, K M Agbodzavu, R Kahuthia-Gathu, K S Akutse, S Muchemi, S Ekesi, K K M Fiaboe
Amaranth is an African indigenous vegetable that is gaining popularity due to its nutritional, medicinal, and economic values. In East Africa, frequent outbreaks of Lepidopteran leaf-webbers, Spoladea recurvalis F. (Lepidoptera: Crambidae) and Udea ferrugalis Hübner (1976) are reported on this crop, causing up to 100% foliage loss. The larval endoparasitoid Apanteles hemara Nixon is also frequently found associated with these pests during the outbreaks, however, its performance on both pests has never been documented...
October 14, 2017: Environmental Entomology
https://www.readbyqxmd.com/read/29043986/potential-of-big-data-analytics-in-the-french-in-vitro-diagnostics-market
#2
Nicolas Dubois, Nicolas Garnier, Christophe Meune
The new paradigm of the big data raises many expectations, particularly in the field of health. Curiously, even though medical biology laboratories generate a great amount of data, the opportunities offered by this new field are poorly documented. For better understanding the clinical context of chronical disease follow-up, for leveraging preventive and/or personalized medicine, the contribution of big data analytics seems very promising. It is within this framework that we have explored to use data of a Breton group of laboratories of medical biology to analyze the possible contributions of their exploitation in the improvement of the clinical practices and to anticipate the evolution of pathologies for the benefit of patients...
October 18, 2017: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/29040063/validation-of-the-six-sigma-z-score-for-the-quality-assessment-of-clinical-laboratory-timeliness
#3
Cristiano Ialongo, Sergio Bernardini
BACKGROUND: The International Federation of Clinical Chemistry and Laboratory Medicine has introduced in recent times the turnaround time (TAT) as mandatory quality indicator for the postanalytical phase. Classic TAT indicators, namely, average, median, 90th percentile and proportion of acceptable test (PAT), are in use since almost 40 years and to date represent the mainstay for gauging the laboratory timeliness. In this study, we investigated the performance of the Six Sigma Z-score, which was previously introduced as a device for the quantitative assessment of timeliness...
October 17, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29039066/pattern-classification-of-enterovirus-71-associated-hand-foot-and-mouth-disease-in-chinese-medicine-a-retrospective-study-in-433-cases
#4
Yan Liu, Li-Yun He, Tian-Cai Wen, Shi-Yan Yan, Wen-Jing Bai, Bao-Yan Liu
OBJECTIVE: To determine whether patterns of enterovirus 71 (EV71)-associated hand, foot, and mouth disease (HFMD) were classified based on symptoms and signs, and explore whether individual characteristics were correlated with membership in particular pattern. METHODS: Symptom-based latent class analysis (LCA) was used to determine whether patterns of EV71-HFMD existed in a sample of 433 cases from a clinical data warehouse system. Logistic regression was then performed to explore whether demographic, and laboratory data were associated with pattern membership...
October 17, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29037833/insights-into-the-background-of-autonomic-medicine
#5
Sérgio Laranjo, Vera Geraldes, Mário Oliveira, Isabel Rocha
Knowledge of the physiology underlying the autonomic nervous system is pivotal for understanding autonomic dysfunction in clinical practice. Autonomic dysfunction may result from primary modifications of the autonomic nervous system or be secondary to a wide range of diseases that cause severe morbidity and mortality. Together with a detailed history and physical examination, laboratory assessment of autonomic function is essential for the analysis of various clinical conditions and the establishment of effective, personalized and precise therapeutic schemes...
October 13, 2017: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/29037824/resource-usage-implementing-the-surgical-resident-prep-curriculum-at-a-single-institution
#6
Lily Owei, Chris Neylan, Rachel Kelz, Kristoffel R Dumon, Steve R Allen, Noel Williams, Daniel T Dempsey, Carla Fisher
OBJECTIVE: The Resident Prep Curriculum (RPC), published in 2014 and developed as a collaboration of the American College of Surgeons, Association of Program Directors in Surgery, and the Association for Surgical Education, was designed to improve the quality and consistency of medical student preparation for surgical residency. We aim to assess the feasibility of and resource usage for implementation of this curriculum at our institution. DESIGN: Our institution expanded upon a pre-existing 2-week surgical preparatory course, adding modules designed to meet the goals and objectives of the RPC...
October 13, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/29037432/acupuncture-for-small-animal-neurological-disorders
#7
REVIEW
Patrick Roynard, Lauren Frank, Huisheng Xie, Margaret Fowler
Modern research on traditional Chinese veterinary medicine (TCVM), including herbal medicine and acupuncture, has made evident the role of the nervous system as a cornerstone in many of the mechanisms of action of TCVM. Laboratory models and clinical research available are supportive for the use of TCVM in the management of neurologic conditions in small animals, specifically in cases of intervertebral disk disease, other myelopathies, and painful conditions. This article is meant to help guide the use of TCVM for neurologic disorders in small animals, based on available information and recommendations from experienced TCVM practitioners...
October 13, 2017: Veterinary Clinics of North America. Small Animal Practice
https://www.readbyqxmd.com/read/29036230/predictors-of-adverse-drug-reaction-related-hospitalisation-in-southwest-ethiopia-a-prospective-cross-sectional-study
#8
Mulugeta Tarekegn Angamo, Colin Michael Curtain, Leanne Chalmers, Daniel Yilma, Luke Bereznicki
BACKGROUND: Adverse drug reactions (ADRs) are important causes of morbidity and mortality in the healthcare system; however, there are no studies reporting on the magnitude and risk factors associated with ADR-related hospitalisation in Ethiopia. OBJECTIVES: To characterise the reaction types and the drugs implicated in admission to Jimma University Specialized Hospital, Southwest Ethiopia, and to identify risk factors associated with ADR-related hospitalisation...
2017: PloS One
https://www.readbyqxmd.com/read/29035979/effect-of-a-commercially-available-footwear-insole-on-biomechanical-variables-associated-with-common-running-injuries
#9
Ryan T Lewinson, Darren J Stefanyshyn
OBJECTIVE: To determine whether Dr. Scholl's Active Series (DSAS) footwear insoles alter biomechanical variables associated with running injuries. DESIGN: Randomized, controlled experiment. SETTING: Sport medicine and biomechanics gait analysis laboratory. PARTICIPANTS: Fifteen healthy adults. INTERVENTIONS: The control condition was the participant's own athletic footwear. The experimental condition was the participant's own athletic footwear plus a DSAS insole...
October 10, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/29035378/molecular-similarities-and-differences-from-human-pulmonary-fibrosis-and-corresponding-mouse-model-maldi-imaging-mass-spectrometry-in-comparative-medicine
#10
Michaela Aichler, Thomas Kunzke, Achim Buck, Na Sun, Maximilian Ackermann, Danny Jonigk, Andreas Gaumann, Axel Walch
Animal models can reproduce some model-specific aspects of human diseases, but some animal models translate poorly or fail to translate to the corresponding human disease. Here, we develop a strategy to systematically compare human and mouse tissues, and conduct a proof-of-concept experiment to identify molecular similarities and differences using patients with idiopathic pulmonary fibrosis and a bleomycin-induced fibrosis mouse model. Our novel approach employs high-throughput tissue microarrays (TMAs) of humans and mice, high-resolution matrix-assisted laser desorption/ionization-Fourier transform-ion cyclotron resonance-mass spectrometry imaging (MALDI-FT-ICR-MSI) to spatially resolve mass spectra at the level of specific metabolites, and hierarchical clustering and pathway enrichment analysis to identify functionally similar/different molecular patterns and pathways in pathological lesions of humans and mice...
October 16, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/29034840/non-anaesthetic-effects-of-volatile-anaesthetics-a-short-trip-on-the-sea-of-translational-medicine
#11
Lukasz J Krzych, Anna J Szczepanska
BACKGROUND: Volatile anaesthetics (VA) are commonly used worldwide for induction and/or maintenance of general anaesthesia. They act in the central nervous system to reduce sensation and motor response during surgical and invasive diagnostic procedures. VAs also have some non-anaesthetic properties in the brain when administrated to patients at the extremes of age. Their biological impact on other organs should be taken into account during administration of anaesthesia. OBJECTIVE: In this review we summarize the recent knowledge on the non-anaesthetic effects of inhaled halogenic ethers on cells and tissues...
October 13, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/29033308/2017-annual-meeting-of-the-american-college-of-radiology-moreton-lecture-forecasting-the-futures-of-radiology
#12
Jeffrey C Bauer
PURPOSE: The traditional forces of change in health care are no longer working as they did in the past. Political gridlock has destroyed Washington's ability to create sensible policy for reforming the medical marketplace, creating chaos for providers. Fortunately, chaos creates opportunity. The idea of creating one's future has never been more relevant and necessary. MATERIALS AND METHODS: Predicting-the science of extrapolating future values from historical data-is not a valid method for looking ahead when causal relationships that explained change in the past are themselves being redefined (the current situation)...
October 13, 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29033026/economic-impact-of-rapid-diagnostic-methods-in-clinical-microbiology-price-of-the-test-or-overall-clinical-impact
#13
Rafael Cantón, Elia Gómez G de la Pedrosa
The need to reduce the time it takes to establish a microbiological diagnosis and the emergence of new molecular microbiology and proteomic technologies has fuelled the development of rapid and point-of-care techniques, as well as the so-called point-of-care laboratories. These laboratories are responsible for conducting both techniques partially to response to the outsourcing of the conventional hospital laboratories. Their introduction has not always been accompanied with economic studies that address their cost-effectiveness, cost-benefit and cost-utility, but rather tend to be limited to the unit price of the test...
October 13, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/29031018/strategies-to-define-performance-specifications-in-laboratory-medicine-3-years-on-from-the-milan-strategic-conference
#14
Mauro Panteghini, Ferruccio Ceriotti, Graham Jones, Wytze Oosterhuis, Mario Plebani, Sverre Sandberg
Measurements in clinical laboratories produce results needed in the diagnosis and monitoring of patients. These results are always characterized by some uncertainty. What quality is needed and what measurement errors can be tolerated without jeopardizing patient safety should therefore be defined and specified for each analyte having clinical use. When these specifications are defined, the total examination process will be "fit for purpose" and the laboratory professionals should then set up rules to control the measuring systems to ensure they perform within specifications...
October 14, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29029106/iatrogenic-cushing-syndrome-in-a-child-with-congenital-adrenal-hyperplasia-erroneous-compounding-of-hydrocortisone
#15
Julia E Barillas, Daniel Eichner, Ryan Van Wagoner, Phyllis W Speiser
Context: Patients with 21-hydroxylase deficiency congenital adrenal hyperplasia (CAH) require lifelong treatment with glucocorticoids. In growing children the drug of choice is hydrocortisone. Commercially available hydrocortisone tablets do not conform to very low doses prescribed to infants and toddlers, and compounded hydrocortisone is often dispensed to meet therapeutic needs. However, safety, efficacy and uniformity of compounded products are not tested. We report a case of Cushing syndrome in a child with CAH who was inadvertently receiving excessive hydrocortisone in compounded form...
September 28, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29028368/a-window-into-clinical-next-generation-sequencing-based-oncology-testing-practices
#16
Rakesh Nagarajan, Angela N Bartley, Julia A Bridge, Lawrence J Jennings, Suzanne Kamel-Reid, Annette Kim, Alexander J Lazar, Neal I Lindeman, Joel Moncur, Alex J Rai, Mark J Routbort, Patricia Vasalos, Jason D Merker
CONTEXT: - Detection of acquired variants in cancer is a paradigm of precision medicine, yet little has been reported about clinical laboratory practices across a broad range of laboratories. OBJECTIVE: - To use College of American Pathologists proficiency testing survey results to report on the results from surveys on next-generation sequencing-based oncology testing practices. DESIGN: - College of American Pathologists proficiency testing survey results from more than 250 laboratories currently performing molecular oncology testing were used to determine laboratory trends in next-generation sequencing-based oncology testing...
October 13, 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29026844/an-interprofessional-collaboration-between-medicine-and-pharmacy-schools-designing-and-evaluating-a-teaching-program-on-practical-prescribing
#17
Mohammad Reza Javadi, Mina Khezrian, Anahita Sadeghi, Seyed Hossein Hajimiri, Kaveh Eslami
OBJECTIVE: Medical students need proper education in drug prescription. The aim of the present study is to introduce a course that improves the students' prescribing skills and also promotes an interprofessional collaboration between medicine and pharmacy schools. METHODS: This study was done in a skill laboratory at the pharmacotherapy department of Tehran University of Medical Sciences, Tehran, Iran. The course was an 18-h interactive workshop in 3 days under the supervision of clinical pharmacists...
July 2017: Journal of Research in Pharmacy Practice
https://www.readbyqxmd.com/read/29026646/binary-titanium-alloys-as-dental-implant-materials-a-review
#18
REVIEW
Xiaotian Liu, Shuyang Chen, James K H Tsoi, Jukka Pekka Matinlinna
Titanium (Ti) has been used for long in dentistry and medicine for implant purpose. During the years, not only the commercially pure Ti but also some alloys such as binary and tertiary Ti alloys were used. The aim of this review is to describe and compare the current literature on binary Ti alloys, including Ti-Zr, Ti-In, Ti-Ag, Ti-Cu, Ti-Au, Ti-Pd, Ti-Nb, Ti-Mn, Ti-Mo, Ti-Cr, Ti-Co, Ti-Sn, Ti-Ge and Ti-Ga, in particular to mechanical, chemical and biological parameters related to implant application. Literature was searched using the PubMed and Web of Science databases, as well as google without limiting the year, but with principle key terms such as ' Ti alloy', 'binary Ti ', 'Ti-X' (with X is the alloy element), 'dental implant' and 'medical implant'...
October 2017: Regenerative Biomaterials
https://www.readbyqxmd.com/read/29025982/appropriate-use-criteria-for-somatostatin-receptor-pet-imaging-in-neuroendocrine-tumors
#19
Thomas A Hope, Emily Bergsland, Murat Fani Bozkurt, Michael M Graham, Anthony P Heaney, Ken Herrmann, James R Howe, Matthew H Kulke, Pamela L Kunz, Josh Mailman, Lawrence May, David C Metz, Corina Millo, Sue O'Dorisio, Diane L Reidy-Lagunes, Michael C Soulen, Jonathan R Strosberg
Somatostatin receptor positron emission tomography (SSTR-PET) is an imaging modality for patients with neuroendocrine tumors (NETs) that has demonstrated a significant improvement over conventional imaging (CI). SSTR-PET should replace In-111 pentetreotide scintigraphy (OctreoScan) in all indications in which SSTR scintigraphy is currently being used. These appropriate use criteria (AUC) are intended to aid referring medical practitioners in the appropriate use of SSTR-PET for imaging of patients with NETs, and the indications were evaluated in well-differentiated NETs...
October 12, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29025354/cell-bound-complement-activation-products-as-lupus-biomarkers-diagnosis-monitoring-and-stratification
#20
Joseph M Ahearn, Chau-Ching Liu, Susan Manzi
Cell-bound complement activation products (CB-CAPs) were first reported in 2004, since which time multiple laboratories have demonstrated their value as biomarkers for diagnosis, monitoring, and stratification of patients with systemic lupus erythematosus. Areas Covered: This review summarizes the highlights of these 14 years of CB-CAPs discovery and validation, concluding with a view toward their future potential for precision medicine. Expert Commentary: The practice of medicine is both art and science and each physician can be considered both artist and scientist with a variable blend of the two skill sets...
October 13, 2017: Expert Review of Clinical Immunology
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