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heat stress nephropathy

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https://www.readbyqxmd.com/read/27545596/heat-shock-proteins-and-diabetes
#1
REVIEW
Marzie Zilaee, Saeed Shirali
Diabetes is a chronic disease, and its prevalence continues to rise and can increase the risk for the progression of microvascular (such as nephropathy, retinopathy and neuropathy) and also macrovascular complications. Diabetes is a condition in which the oxidative stress and inflammation rise. Heat shock proteins (HSPs) are a highly conserved family of proteins that are expressed by all cells exposed to environmental stress, and they have diverse functions. In patients with diabetes, the expression and levels of HSPs decrease, but these chaperones can aid in improving some complications of diabetes, such as oxidative stress and inflammation...
December 2016: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/27151892/climate-change-and-the-emergent-epidemic-of-ckd-from-heat-stress-in-rural-communities-the-case-for-heat-stress-nephropathy
#2
Jason Glaser, Jay Lemery, Balaji Rajagopalan, Henry F Diaz, Ramón García-Trabanino, Gangadhar Taduri, Magdalena Madero, Mala Amarasinghe, Georgi Abraham, Sirirat Anutrakulchai, Vivekanand Jha, Peter Stenvinkel, Carlos Roncal-Jimenez, Miguel A Lanaspa, Ricardo Correa-Rotter, David Sheikh-Hamad, Emmanuel A Burdmann, Ana Andres-Hernando, Tamara Milagres, Ilana Weiss, Mehmet Kanbay, Catharina Wesseling, Laura Gabriela Sánchez-Lozada, Richard J Johnson
Climate change has led to significant rise of 0.8°C-0.9°C in global mean temperature over the last century and has been linked with significant increases in the frequency and severity of heat waves (extreme heat events). Climate change has also been increasingly connected to detrimental human health. One of the consequences of climate-related extreme heat exposure is dehydration and volume loss, leading to acute mortality from exacerbations of pre-existing chronic disease, as well as from outright heat exhaustion and heat stroke...
August 8, 2016: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/26455995/heat-stress-nephropathy-from-exercise-induced-uric-acid-crystalluria-a-perspective-on-mesoamerican-nephropathy
#3
Carlos Roncal-Jimenez, Ramón García-Trabanino, Lars Barregard, Miguel A Lanaspa, Catharina Wesseling, Tamara Harra, Aurora Aragón, Felix Grases, Emmanuel R Jarquin, Marvin A González, Ilana Weiss, Jason Glaser, Laura G Sánchez-Lozada, Richard J Johnson
Mesoamerican nephropathy (MeN), an epidemic in Central America, is a chronic kidney disease of unknown cause. In this article, we argue that MeN may be a uric acid disorder. Individuals at risk for developing the disease are primarily male workers exposed to heat stress and physical exertion that predisposes to recurrent water and volume depletion, often accompanied by urinary concentration and acidification. Uric acid is generated during heat stress, in part consequent to nucleotide release from muscles. We hypothesize that working in the sugarcane fields may result in cyclic uricosuria in which uric acid concentrations exceed solubility, leading to the formation of dihydrate urate crystals and local injury...
January 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/26307981/ages-induced-il-6-synthesis-precedes-rage-up-regulation-in-hek-293-cells-an-alternative-inflammatory-mechanism
#4
Andreea Iren Serban, Loredana Stanca, Ovidiu Ionut Geicu, Anca Dinischiotu
Advanced glycation end products (AGEs) can activate the inflammatory pathways involved in diabetic nephropathy. Understanding these molecular pathways could contribute to therapeutic strategies for diabetes complications. We evaluated the modulation of inflammatory and oxidative markers, as well as the protective mechanisms employed by human embryonic kidney cells (HEK 293) upon exposure to 200 μg/mL bovine serum albumine (BSA) or AGEs-BSA for 12, 24 and 48 h. The mRNA and protein expression levels of AGEs receptor (RAGE) and heat shock proteins (HSPs) 27, 60 and 70, the activity of antioxidant enzymes and the expression levels of eight cytokines were analysed...
2015: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/26228633/mediators-and-mechanisms-of-heat-shock-protein-70-based-cytoprotection-in-obstructive-nephropathy
#5
REVIEW
Luciana Mazzei, Neil G Docherty, Walter Manucha
Urinary heat shock protein 70 (Hsp70) is rapidly increased in patients with clinical acute kidney injury, indicating that it constitutes a component of the endogenous stress response to renal injury. Moreover, experimental models have demonstrated that Hsp70 activation is associated with the cytoprotective actions of several drugs following obstruction, including nitric oxide (NO) donors, geranylgeranylacetone, vitamin D, and rosuvastatin. Discrete and synergistic effects of the biological activities of Hsp70 may explain its cytoprotective role in obstructive nephropathy...
November 2015: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/26209462/heat-stress-dehydration-and-kidney-function-in-sugarcane-cutters-in-el-salvador-a-cross-shift-study-of-workers-at-risk-of-mesoamerican-nephropathy
#6
Ramón García-Trabanino, Emmanuel Jarquín, Catharina Wesseling, Richard J Johnson, Marvin González-Quiroz, Ilana Weiss, Jason Glaser, Juan José Vindell, Leo Stockfelt, Carlos Roncal, Tamara Harra, Lars Barregard
BACKGROUND: An epidemic of progressive kidney failure afflicts sugarcane workers in Central America. Repeated high-intensity work in hot environments is a possible cause. OBJECTIVES: To assess heat stress, dehydration, biomarkers of renal function and their possible associations. A secondary aim was to evaluate the prevalence of pre-shift renal damage and possible causal factors. METHODS: Sugarcane cutters (N=189, aged 18-49 years, 168 of them male) from three regions in El Salvador were examined before and after shift...
October 2015: Environmental Research
https://www.readbyqxmd.com/read/26116697/targeting-hsp90-ameliorates-nephropathy-and-atherosclerosis-through-suppression-of-nf-%C3%AE%C2%BAb-and-stat-signaling-pathways-in-diabetic-mice
#7
Iolanda Lazaro, Ainhoa Oguiza, Carlota Recio, Beñat Mallavia, Julio Madrigal-Matute, Julia Blanco, Jesus Egido, Jose-Luis Martin-Ventura, Carmen Gomez-Guerrero
Heat shock proteins (HSPs) are induced by cellular stress and function as molecular chaperones that regulate protein folding. Diabetes impairs the function/expression of many HSPs, including HSP70 and HSP90, key regulators of pathological mechanisms involved in diabetes complications. Therefore, we investigated whether pharmacological HSP90 inhibition ameliorates diabetes-associated renal damage and atheroprogression in a mouse model of combined hyperglycemia and hyperlipidemia (streptozotocin-induced diabetic apolipoprotein E-deficient mouse)...
October 2015: Diabetes
https://www.readbyqxmd.com/read/25567807/impact-of-er-stress-regulated-atf4-p16-signaling-on-the-premature-senescence-of-renal-tubular-epithelial-cells-in-diabetic-nephropathy
#8
Jun Liu, Ju-Rong Yang, Xiang-Mei Chen, Guang-Yan Cai, Li-Rong Lin, Ya-Ni He
Premature senescence is an important event during diabetic nephropathy (DN) progression. Here, we investigated the role of endoplasmic reticulum (ER) stress-regulated activation of transcription factor 4 (ATF4)/p16 signaling in the premature senescence of renal tubular epithelial cells (RTECs) during DN development. In the renal tissues of Type 2 DN patients, we detected an increased number of senescent cells; elevated deposition of advanced glycation end products (AGEs); upregulated expression of ER stress marker, glucose-regulated protein 78; as well as overexpression of ATF4 and p16...
April 15, 2015: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/25301743/selenium-nanoparticles-involve-hsp-70-and-sirt1-in-preventing-the-progression-of-type-1-diabetic-nephropathy
#9
Goru Santosh Kumar, Apoorva Kulkarni, Amit Khurana, Jasmine Kaur, Kulbhushan Tikoo
The present study was undertaken to examine the protective effect of selenium nanoparticles (SeNPs) in the progression of diabetic nephropathy (DN). Diabetes was induced in male Sprague Dawley (SD) rats by injecting streptozotocin (STZ) (55mg/kg, i.p). DN was then assessed by measuring blood urea nitrogen (BUN), creatinine, albumin, fibronectin and collagen. Changes in the expression of cytoprotective and apoptotic proteins in the kidney of rats were also examined. Herein we show that SeNPs effectively lowered the levels of BUN, creatinine, fibronectin and collagen and elevated the levels of albumin in diabetic rats...
November 5, 2014: Chemico-biological Interactions
https://www.readbyqxmd.com/read/25091486/the-heat-shock-response-its-role-in-pathogenesis-of-type-2-diabetes-and-its-complications-and-implications-for-therapeutic-intervention
#10
REVIEW
Indira Padmalayam
The heat shock response (HSR) is an evolutionarily conserved mechanism that cells and organisms utilize to protect themselves from the damaging effects of stress. Induction of HSR involves a complex multi-step process in which heat shock factor-1 (HSF-1), the key modulator of HSR, is activated, leading to the induction of a variety of heat shock genes. There is evidence that the HSR is defective in diabetes, which makes the tissues vulnerable to stress-induced pathological changes. Consistent with this observation, induction of HSR by either non-pharmacological methods such as hyperthermia or by pharmacological inducers has beneficial effects in managing insulin resistance and hyperglycemia, as well as secondary complications of diabetes, such as cardiovascular disease, nephropathy, neuropathy, and retinopathy as well as wound healing...
July 2014: Discovery Medicine
https://www.readbyqxmd.com/read/25012492/down-regulation-of-perk-atf4-chop-pathway-by-astragaloside-iv-is-associated-with-the-inhibition-of-endoplasmic-reticulum-stress-induced-podocyte-apoptosis-in-diabetic-rats
#11
Yifang Chen, Dingkun Gui, Jianguo Chen, Dongyuan He, Yunling Luo, Niansong Wang
BACKGROUND: Endoplasmic reticulum (ER) stress-induced podocyte apoptosis plays a critical role in the development of diabetic nephropathy (DN). Here, we tested the hypothesis that suppression of PERK-ATF4-CHOP pathway by Astragaloside IV (AS-IV) is associated with inhibition of ER stress-induced podocyte apoptosis in streptozotocin (STZ)-induced diabetic rats. METHODS: Diabetic rats were treated with AS-IV at 5 and 10 mg·kg-1·d-1, p.o., for 12 weeks. Albuminuria examination, hematoxylin & eosin staining and TUNEL analysis were performed...
2014: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/24878645/risk-factors-for-reduced-glomerular-filtration-rate-in-a-nicaraguan-community-affected-by-mesoamerican-nephropathy
#12
Nathan Raines, Marvin González, Christina Wyatt, Mark Kurzrok, Christopher Pool, Tiziana Lemma, Ilana Weiss, Carlos Marín, Valerio Prado, Eugenia Marcas, Karina Mayorga, Jean Franco Morales, Aurora Aragón, Perry Sheffield
INTRODUCTION: Mesoamerican nephropathy, also known as chronic kidney disease of unknown etiology, is widespread in Pacific coastal Central America. The cause of the epidemic is unknown, but the disease may be linked to multiple factors, including diet as well as environmental and occupational exposures. As many as 50% of men in some communities have Mesoamerican nephropathy. OBJECTIVE: Describe prevalence of reduced glomerular filtration rate in a region of Nicaragua suspected to harbor high rates of Mesoamerican nephropathy; and investigate potential risk factors for such reduction associated with agricultural work (such as pesticide exposure and specific agricultural tasks associated with increased heat stress); sugar consumption; and traditional factors such as age, sex, diabetes, hypertension and nephrotoxic medication use...
April 2014: MEDICC Review
https://www.readbyqxmd.com/read/24827579/transcriptome-based-analysis-of-kidney-gene-expression-changes-associated-with-diabetes-in-ove26-mice-in-the-presence-and-absence-of-losartan-treatment
#13
Radko Komers, Bei Xu, Yi Fu, Aaron McClelland, Phillip Kantharidis, Amit Mittal, Herbert T Cohen, David M Cohen
Diabetes is among the most common causes of end-stage renal disease, although its pathophysiology is incompletely understood. We performed next-generation sequencing-based transcriptome analysis of renal gene expression changes in the OVE26 murine model of diabetes (age 15 weeks), relative to non-diabetic control, in the presence and absence of short-term (seven-day) treatment with the angiotensin receptor blocker, losartan (n = 3-6 biological replicates per condition). We detected 1438 statistically significant changes in gene expression across conditions...
2014: PloS One
https://www.readbyqxmd.com/read/24667182/pemt-deficiency-ameliorates-endoplasmic-reticulum-stress-in-diabetic-nephropathy
#14
Mayu Watanabe, Atsuko Nakatsuka, Kazutoshi Murakami, Kentaro Inoue, Takahiro Terami, Chigusa Higuchi, Akihiro Katayama, Sanae Teshigawara, Jun Eguchi, Daisuke Ogawa, Eijiro Watanabe, Jun Wada, Hirofumi Makino
Phosphatidylethanolamine N-methyltransferase (Pemt) catalyzes the methylation of phosphatidylethanolamine (PE) to phosphatidylcholine (PC) mainly in the liver. Under an obese state, the upregulation of Pemt induces endoplasmic reticulum (ER) stress by increasing the PC/PE ratio in the liver. We targeted the Pemt gene in mice to explore the therapeutic impact of Pemt on the progression of diabetic nephropathy and diabetes, which was induced by the injection of streptozotocin (STZ). Although the blood glucose levels were similar in STZ-induced diabetic Pemt+/+ and Pemt-/-mice, the glomerular hypertrophy and albuminuria in Pemt-/- mice were significantly reduced...
2014: PloS One
https://www.readbyqxmd.com/read/24503896/role-of-endoplasmic-reticulum-stress-in-apoptosis-of-differentiated-mouse-podocytes-induced-by-high-glucose
#15
Yanping Cao, Yongmei Hao, Hang Li, Qingjuan Liu, Feng Gao, Wei Liu, Huijun Duan
Podocytes are terminally differentiated epithelial cells lacking the ability to proliferate. The loss of podocytes is a hallmark of progressive kidney diseases, including diabetic nephropathy (DN). Endoplasmic reticulum stress (ERS)-induced apoptosis is involved in a number of pathological conditions, including DN. The aim of the present study was to investigate whether a high glucose environment induces the apoptosis of podocytes through ERS. Differentiated mouse podocytes were divided into three groups: the normal glucose group (NG, 1 g/l D-glucose), the high glucose group (HG, 4...
April 2014: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/24452638/er-stress-triggers-mcp-1-expression-through-set7-9-induced-histone-methylation-in-the-kidneys-of-db-db-mice
#16
Jigang Chen, Yanhong Guo, Wei Zeng, Li Huang, Qi Pang, Ling Nie, Jiao Mu, Fahuan Yuan, Bing Feng
Epigenetics plays a key role in the pathogenesis of diabetic nephropathy (DN), although the precise regulatory mechanism is still unclear. Here, we examined the role of endoplasmic reticulum (ER) stress in histone H3 lysine 4 (H3K4) methyltransferase SET7/9-induced monocyte chemoattractant protein-1 (MCP-1) expression in the kidneys of db/db mice. Our results indicate that the expression of MCP-1 significantly increased in the kidneys of db/db mice in a time-dependent manner. An increased chromatin mark associated with an active gene (H3K4me1) at MCP-1 promoters accompanied this change in expression...
April 15, 2014: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/24262798/evidence-for-activation-of-the-unfolded-protein-response-in-collagen-iv-nephropathies
#17
Myrtani Pieri, Charalambos Stefanou, Apostolos Zaravinos, Kamil Erguler, Kostas Stylianou, George Lapathitis, Christos Karaiskos, Isavella Savva, Revekka Paraskeva, Harsh Dweep, Carsten Sticht, Natassa Anastasiadou, Ioanna Zouvani, Demetris Goumenos, Kyriakos Felekkis, Moin Saleem, Konstantinos Voskarides, Norbert Gretz, Constantinos Deltas
Thin-basement-membrane nephropathy (TBMN) and Alport syndrome (AS) are progressive collagen IV nephropathies caused by mutations in COL4A3/A4/A5 genes. These nephropathies invariably present with microscopic hematuria and frequently progress to proteinuria and CKD or ESRD during long-term follow-up. Nonetheless, the exact molecular mechanisms by which these mutations exert their deleterious effects on the glomerulus remain elusive. We hypothesized that defective trafficking of the COL4A3 chain causes a strong intracellular effect on the cell responsible for COL4A3 expression, the podocyte...
February 2014: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/24233065/heat-processed-panax-ginseng-and-diabetic-renal-damage-active-components-and-action-mechanism
#18
REVIEW
Ki Sung Kang, Jungyeob Ham, Young-Joo Kim, Jeong Hill Park, Eun-Ju Cho, Noriko Yamabe
Diabetic nephropathy is one of the serious complications in patients with either type 1 or 2 diabetes mellitus but current treatments remain unsatisfactory. Results of clinical research studies demonstrate that Panax ginseng can help adjust blood pressure and reduce blood sugar and may be advantageous in the treatment of tuberculosis and kidney damage in people with diabetes. The heat-processing method to strengthen the efficacy of P. ginseng has been well-defined based on a long history of ethnopharmacological evidence...
October 2013: Journal of Ginseng Research
https://www.readbyqxmd.com/read/24140367/resolving-the-enigma-of-the-mesoamerican-nephropathy-a-research-workshop-summary
#19
REVIEW
Catharina Wesseling, Jennifer Crowe, Christer Hogstedt, Kristina Jakobsson, Rebekah Lucas, David H Wegman
The First International Research Workshop on Mesoamerican Nephropathy (MeN) met in Costa Rica in November 2012 to discuss how to establish the extent and degree of MeN, examine relevant causal hypotheses, and focus efforts to control or eliminate the disease burden. MeN describes a devastating epidemic of chronic kidney disease of unknown origin predominantly observed among young male sugarcane cutters. The cause of MeN remains uncertain; however, the strongest hypothesis pursued to date is repeated episodes of occupational heat stress and water and solute loss, probably in combination with other potential risk factor(s), such as nonsteroidal anti-inflammatory drug and other nephrotoxic medication use, inorganic arsenic, leptospirosis, or pesticides...
March 2014: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/22971995/tubular-expression-of-heat-shock-protein-27-inhibits-fibrogenesis-in-obstructive-nephropathy
#20
Aparna Vidyasagar, Shannon R Reese, Omeed Hafez, Ling-Jin Huang, William F Swain, Lynn M Jacobson, Jose R Torrealba, Pierre-Emmanuel Chammas, Nancy A Wilson, Arjang Djamali
Morphological changes that occur during kidney injury involve actin skeleton remodeling. Here we tested whether heat-shock protein 27 (HSP27), a small stress response protein involved in cytoskeletal remodeling, protects the kidney from tubulointerstitial fibrosis in obstructive nephropathy. Tubular cell HSP27 immunostaining was significantly increased in human kidneys with ureteropelvic junction obstruction, supporting the clinical relevance of our studies. To develop an animal model for mechanistic studies, we generated transgenic mice that specifically overexpress human HSP27 in renal tubules, under the kidney androgen-regulated protein promoter, and determined the effects of HSP27 overexpression on epithelial-to-mesenchymal transition and tubulointerstitial fibrosis following unilateral ureteral obstruction...
January 2013: Kidney International
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