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Ping He, Kim Kramer, Peter Smith-Jones, Pat Zanzonico, John Humm, Steven M Larson, Nai-Kong V Cheung
PURPOSE: Radioimmunotherapy (RIT) using (131)I-3F8 injected into cerebrospinal fluid (CSF) was a safe modality for the treatment of leptomeningeal metastases (JCO, 25:5465, 2007). A single-compartment pharmacokinetic model described previously (JNM 50:1324, 2009) showed good fitting to the CSF radioactivity data obtained from patients. We now describe a two-compartment model to account for the ventricular reservoir of (131)I-3F8 and to identify limiting factors that may impact therapeutic ratio...
February 2011: European Journal of Nuclear Medicine and Molecular Imaging
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