keyword
https://read.qxmd.com/read/38496157/the-role-of-diet-in-the-management-of-irritable-bowel-syndrome-a-comprehensive-review
#1
REVIEW
Maleesha Jayasinghe, Vinuri Karunanayake, Ali Mohtashim, Dilushini Caldera, Piyalka Mendis, Omesh Prathiraja, Fatemeh Rashidi, John A Damianos
Irritable bowel syndrome (IBS) is a highly prevalent gastrointestinal disorder that has a significant impact on the general population. The suboptimal medical treatments available for IBS contribute to its large economic burden. The pathophysiology of IBS is complex, and treatments often focus on managing specific symptoms. Many individuals with IBS associate their symptoms with specific food intake, leading to increased scientific research on the role of diet in managing IBS. Dietary management has become a crucial aspect of IBS treatment, with initial recommendations focusing on adopting a healthy eating pattern and lifestyle...
February 2024: Curēus
https://read.qxmd.com/read/38494694/large-yellow-tea-polysaccharide-alleviates-hfd-induced-intestinal-homeostasis-dysbiosis-via-modulating-gut-barrier-integrity-immune-responses-and-the-gut-microbiome
#2
JOURNAL ARTICLE
Yan Ma, Hai Xie, Na Xu, Minni Li, Lan Wang, Huifang Ge, Zhongwen Xie, Daxiang Li, Hongyan Wang
Long-term high-fat diet (HFD) will induce dysbiosis and a disturbance of intestinal homeostasis. Large yellow tea polysaccharide (LYP) has been shown to improve obesity-associated metabolic disease via modulation of the M2 polarization. However, the contribution of LYP to intestinal barrier impairment and improvement mechanisms in obesity caused by an HFD are still not clear. In this study, we evaluated the impacts of LYP on the mucosal barrier function and microbiota composition in HFD-feeding mice. Results exhibited that dietary LYP supplement could ameliorate the physical barrier function via maintaining intestinal mucosal integrity and elevating tight-junction protein production, strengthen the chemical barrier function via up-regulating the levels of glucagon-like peptide-1 and increasing mucin-producing goblet cell numbers, and enhance the intestinal immune barrier function though suppressing immune cell subsets and cytokines toward pro-inflammatory phenotypes...
March 17, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38494583/polycystic-ovary-syndrome-and-irritable-bowel-syndrome-is-there-a-common-pathway
#3
REVIEW
Marzieh Saei Ghare Naz, Vida Ghasemi, Shabahang Amirshekari, Fahimeh Ramezani Tehrani
OBJECTIVE: Little is known about how polycystic ovary syndrome (PCOS) is linked to irritable bowel syndrome (IBS). This study aimed to review the existing literature regarding the association between PCOS or its symptoms and complications with IBS. METHODS: In this review, studies that investigated the proposed cross-link between features of PCOS and IBS were included. This review collectively focused on recent findings on the mechanism and novel insight regarding the association between IBS and PCOS in future clinical practice...
March 2024: Endocrinology, Diabetes & Metabolism
https://read.qxmd.com/read/38493617/complete-ileal-obstruction-secondary-to-a-22-year-old-non-absorbable-suture-for-an-open-appendectomy-clinical-case-report
#4
Yasir Alshareefy, Tala Muassess, Mahpara Mir, Hussam Altrabulsi, Ali Alshareefy
INTRODUCTION: Small bowel obstruction (SBO) is a common surgical emergency. Our report describes a case of a 61-year-old male who was found to have a PROLENE suture left in situ from a previous open appendectomy 22 years ago, over which a fibrous adhesive band had formed, resulting in a terminal ileal volvulus and subsequent SBO. CASE: A 61-year-old male presented with a 3-day history of severe lower abdominal cramps, nausea and constipation. A previous open appendectomy, performed 22 years ago, was the only significant detail in his medical history...
March 16, 2024: International Journal of Surgery Case Reports
https://read.qxmd.com/read/38492475/evaluating-outcomes-and-toxicities-for-a-newly-implemented-mri-based-brachytherapy-program-for-cervical-cancer
#5
JOURNAL ARTICLE
Dylan H Ross, Kayeromi Gomez, Grant Harmon, Michael L Mysz, Steven M Shea, Ari Goldberg, Margaret Liotta, Ronald Potkul, Abigail Winder, Brian Lee, Jacob Jackson, John C Roeske, William Small, Matthew M Harkenrider
OBJECTIVE: We report an updated analysis of the outcomes and toxicities of MRI-based brachytherapy for locally advanced cervical cancer from a U.S. academic center. METHODS: A retrospective review was performed on patients treated with MRI-based brachytherapy for cervical cancer. EBRT was standardly 45 Gy in 25 fractions with weekly cisplatin. MRI was performed with the brachytherapy applicator in situ. Dose specification was most commonly 7 Gy for 4 fractions with optimization aim of D90 HR-CTV EQD2 of 85-95 Gyα/β=10 Gy in 2 implants each delivering 2 fractions...
March 15, 2024: Gynecologic Oncology
https://read.qxmd.com/read/38490882/incidence-and-risk-factors-for-chyle-leaks-after-neuroblastic-tumor-resection-a-systematic-review-of-published-studies
#6
REVIEW
Arimatias Raitio, Paul D Losty
BACKGROUND: Chyle leakage/ascites after surgical resection of neuroblastic tumors may delay the start of chemotherapy and worsen prognosis. Previous studies have reported a highly variable incidence and risk factors remain largely unknown. This study aims to analyze the true incidence of chyle leaks and ascites and seeks to identify risk factors and optimal treatment strategies. METHODS: Medline/Embase databases were searched according to PRISMA guidelines. Literature reviews, case reports, and non-English papers were excluded...
February 26, 2024: Journal of Pediatric Surgery
https://read.qxmd.com/read/38488549/potential-role-of-hippocampal-neurogenesis-in-spinal-cord-injury-induced-post-trauma-depression
#7
JOURNAL ARTICLE
Ying Ma, Yue Qiao, Xiang Gao
It has been reported both in clinic and rodent models that beyond spinal cord injury directly induced symptoms, such as paralysis, neuropathic pain, bladder/bowel dysfunction, and loss of sexual function, there are a variety of secondary complications, including memory loss, cognitive decline, depression, and Alzheimer's disease. The large-scale longitudinal population-based studies indicate that post-trauma depression is highly prevalent in spinal cord injury patients. Yet, few basic studies have been conducted to address the potential molecular mechanisms...
October 1, 2024: Neural Regeneration Research
https://read.qxmd.com/read/38488211/osteopathic-manipulative-treatment-for-chronic-inflammatory-diseases
#8
REVIEW
Ross Gillan, Gabrielle Bachtel, Kassidy Webber, Yasmine Ezzair, Nicole E Myers, Anupam Bishayee
Chronic inflammatory diseases (CIDs) are debilitating and potentially lethal illnesses that affect a large proportion of the global population. Osteopathic manipulative treatment (OMT) is a manual therapy technique developed and performed by osteopathic physicians that facilitates the body's innate healing processes. Therefore, OMT may prove a beneficial anti-inflammatory modality useful in the management and treatment of CIDs. This work aims to objectively evaluate the therapeutic benefits of OMT in patients with various CIDs...
March 15, 2024: Journal of Evidence-based Medicine
https://read.qxmd.com/read/38487904/-ileo-colic-intussusception-in-adult-secondary-to-a-large-neoplasia-of-the-lower-caecal-fundus
#9
Céline Bodson, Bernard Geurde, Jean-Luc Jourdan, Morgane Leonard, Benoit Seydel
Intussusception is rare in adults, accounting for 1 to 5 % of mechanical bowel obstructions. It is due to pathologic lead point within the bowel which is malignant in up to 77 % of cases. Benign lesions may also be responsible for intussusception (polyp, Meckel diverticulum). The lead point is pulled forward by normal peristaltism, prolapsing the affected segment of bowel into another segment. The most common presentation in adults is intermittent abdominal pain and bowel obstruction (nausea, vomiting, inability to pass gas or stools)...
March 2024: Revue Médicale de Liège
https://read.qxmd.com/read/38482512/effect-of-foot-reflexology-on-patients-with-multiple-sclerosis-a-systematic-review-of-current-evidence
#10
JOURNAL ARTICLE
Boopalan Deenadayalan, Vijayakumar Venugopal, Ravi Poornima, Vanamoorthy Mahesh Kannan, Anandhan Akila, Chidambaram Yogapriya, Kuppusamy Maheshkumar
BACKGROUND: Individuals with multiple sclerosis (MS) commonly experience fatigue, discomfort, sleep problems, anxiety, and reduced quality of life. Studies have shown that foot reflexology can help relieve these symptoms. The objective of this current study is to systematically review the effects of foot reflexology on patients with MS. METHODS: We conducted a systematic review of published literature in many databases, including PubMed, EMBASE, and Cochrane Library, from January 1, 2000, to January 27, 2022...
2024: International Journal of MS Care
https://read.qxmd.com/read/38481740/case-report-foetal-gastroschisis-with-ideal-pregnancy-outcomes-under-multidisciplinary-treatment-management
#11
Shuhua Liu, Jingyu Qian, Qiuru Li, Dehong Liu, Bin Zhang, Xianxia Chen
BACKGROUND: Gastroschisis has increased in recent years, however, complicated gastroschisis is associated with higher mortality, as well as higher health care costs and disease burdens from short- and long-term complications. CASE INTRODUCTION: A woman aged 25 years old at 37 + 1 weeks gestation (gravida 2; para 0) was admitted to the hospital because of foetal gastroschisis. Targeted quaternary ultrasound performed at our hospital showed that 34 mm of the abdominal wall was interrupted continuously, an intestinal echo with a range of approximately 88 × 50 mm was seen bulging outwards the local area close to the intestinal wall showed a 34 × 23 m anecho, and the foetus was measuring 2 weeks smaller than expected...
2024: Frontiers in Pediatrics
https://read.qxmd.com/read/38479936/efficacy-and-safety-of-probiotics-in-irritable-bowel-syndrome-a-systematic-review-and-meta-analysis
#12
JOURNAL ARTICLE
Ruwen Yang, Jiawei Jiang, Jun Ouyang, Yuanpei Zhao, Biao Xi
BACKGROUND: Irritable bowel syndrome (IBS) is a common gastrointestinal disease characterized by abdominal pain, distension, and altered bowel habits. Probiotics may alleviate IBS symptoms, but clinical trials remain conflicting. AIMS: To conduct a systematic review and meta-analysis of clinical trials to evaluate the efficacy and safety of probiotics for IBS patients. METHODS: We searched relevant trials in PubMed, Web of Science, Embase, Cochrane Library, and Google Scholar from 2000 to June 2023...
April 2024: Clinical Nutrition ESPEN
https://read.qxmd.com/read/38478397/attenuation-of-colitis-induced-visceral-hypersensitivity-and-pain-by-selective-silencing-of-trpv1-expressing-fibers-in-rat-colon
#13
JOURNAL ARTICLE
Yoav Mazor, Nurit Engelmayer, Halla Nashashibi, Lisa Rottenfußer, Shaya Lev, Alexander M Binshtok
BACKGROUND: Transient receptor potential vanilloid 1 (TRPV1) cation channels, expressed on nociceptors, are well established as key contributors to abdominal pain in inflammatory bowel disease (IBD). Previous attempts at blocking these channels have been riddled with side effects. Here, we propose a novel treatment strategy, utilizing the large pore of TRPV1 channels as a drug delivery system to selectively inhibit visceral nociceptors. METHODS: We induced colitis in rats using intrarectal dinitrobenzene sulfonic acid...
March 13, 2024: Inflammatory Bowel Diseases
https://read.qxmd.com/read/38477494/transvaginal-mesh-or-grafts-or-native-tissue-repair-for-vaginal-prolapse
#14
REVIEW
Ellen Yeung, Kaven Baessler, Corina Christmann-Schmid, Nir Haya, Zhuoran Chen, Sheila A Wallace, Alex Mowat, Christopher Maher
BACKGROUND: Pelvic organ prolapse is the descent of one or more of the pelvic organs (uterus, vaginal apex, bladder, or bowel) into the vagina. In recent years, surgeons have increasingly used grafts in transvaginal repairs. Graft material can be synthetic or biological. The aim is to reduce prolapse recurrence and surpass the effectiveness of traditional native tissue repair (colporrhaphy) for vaginal prolapse. This is a review update; the previous version was published in 2016. OBJECTIVES: To determine the safety and effectiveness of transvaginal mesh or biological grafts compared to native tissue repair or other grafts in the surgical treatment of vaginal prolapse...
March 13, 2024: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/38476652/anti-ulcerative-colitis-effects-of-chemically-characterized-extracts-from-c-alliandra-haematocephala-in-acetic-acid-induced-ulcerative-colitis
#15
JOURNAL ARTICLE
Inaam Ur Rehman, Mohammad Saleem, Syed Atif Raza, Saher Bashir, Taha Muhammad, Shahzad Asghar, Muhammad Usman Qamar, Tawaf Ali Shah, Yousef A Bin Jardan, Amare Bitew Mekonnen, Mohammed Bourhia
Background: Ulcerative colitis is a chronic immune-mediated inflammatory bowel disease that involves inflammation and ulcers of the colon and rectum. To date, no definite cure for this disease is available. Objective: The objective of the current study was to assess the effect of Calliandra haematocephala on inflammatory mediators and oxidative stress markers for the exploration of its anti-ulcerative colitis activity in rat models of acetic acid-induced ulcerative colitis. Methods: Methanolic and n-hexane extracts of areal parts of the plant were prepared by cold extraction method...
2024: Frontiers in Chemistry
https://read.qxmd.com/read/38474337/allopurinol-disrupts-purine-metabolism-to-increase-damage-in-experimental-colitis
#16
JOURNAL ARTICLE
Corey S Worledge, Rachael E Kostelecky, Liheng Zhou, Geetha Bhagavatula, Sean P Colgan, J Scott Lee
Inflammatory bowel disease (IBD) is marked by a state of chronic energy deficiency that limits gut tissue wound healing. This energy shortfall is partially due to microbiota dysbiosis, resulting in the loss of microbiota-derived metabolites, which the epithelium relies on for energy procurement. The role of microbiota-sourced purines, such as hypoxanthine, as substrates salvaged by the colonic epithelium for nucleotide biogenesis and energy balance, has recently been appreciated for homeostasis and wound healing...
February 21, 2024: Cells
https://read.qxmd.com/read/38472946/polypoid-lesion-segmentation-using-yolo-v8-network-in-wireless-video-capsule-endoscopy-images
#17
JOURNAL ARTICLE
Ali Sahafi, Anastasios Koulaouzidis, Mehrshad Lalinia
Gastrointestinal (GI) tract disorders are a significant public health issue. They are becoming more common and can cause serious health problems and high healthcare costs. Small bowel tumours (SBTs) and colorectal cancer (CRC) are both becoming more prevalent, especially among younger adults. Early detection and removal of polyps (precursors of malignancy) is essential for prevention. Wireless Capsule Endoscopy (WCE) is a procedure that utilises swallowable camera devices that capture images of the GI tract...
February 22, 2024: Diagnostics
https://read.qxmd.com/read/38472215/hypoxia-and-low-glucose-environments-co-induced-hgdilnc1-promote-glycolysis-and-angiogenesis
#18
JOURNAL ARTICLE
Qing-Wei Zhang, Xiao-Lu Lin, Zi-Hao Dai, Ran Zhao, Yi-Chao Hou, Qian Liang, Yan Zhang, Zhi-Zheng Ge
Small bowel vascular malformation disease (SBVM) commonly causes obscure gastrointestinal bleeding (OGIB). However, the pathogenetic mechanism and the role of lncRNAs in SBVM remain largely unknown. Here, we found that hypoxia and low-glucose environments co-augment angiogenesis and existed in SBVM. Mechanistically, hypoxia and low-glucose environments supported angiogenesis via activation of hypoxia and glucose deprivation-induced lncRNA (HGDILnc1) transcription by increasing binding of the NeuroD1 transcription factor to the HGDILnc1 promoter...
March 12, 2024: Cell Death Discovery
https://read.qxmd.com/read/38471217/explorative-laparotomy-of-cecal-volvulus-in-a-pediatric-patient-a-case-report-and-review-of-literature
#19
Lujain Alzahrani, Faisal Joueidi, Fawzy Mohamed Abodahab, Khaled Joueidi, Asim Khan
INTRODUCTION AND IMPORTANCE: Cecal volvulus is a rare intestinal pathology that occurs due to abnormal cecum mobility associated with spectrum of complications. It is usually manifested in adults. However, on extremely rare occasions, it occurs in pediatrics. We presented a case of cecal volvulus demonstrating the significance of early diagnosis and treatment to reach successful outcomes. CASE PRESENTATION: A 12 year old boy who presented to the emergency department for clinical evaluation for acute abdomen...
March 11, 2024: International Journal of Surgery Case Reports
https://read.qxmd.com/read/38470044/-anaerostipes-hadrus-a-butyrate-producing-bacterium-capable-of-metabolizing-5-fluorouracil
#20
JOURNAL ARTICLE
Danping Liu, Li-Sheng Xie, Shitao Lian, Kexin Li, Yun Yang, Wen-Zhao Wang, Songnian Hu, Shuang-Jiang Liu, Chang Liu, Zilong He
UNLABELLED: Anaerostipes hadrus ( A. hadrus ) is a dominant species in the human gut microbiota and considered a beneficial bacterium for producing probiotic butyrate. However, recent studies have suggested that A. hadrus may negatively affect the host through synthesizing fatty acid and metabolizing the anticancer drug 5-fluorouracil, indicating that the impact of A. hadrus is complex and unclear. Therefore, comprehensive genomic studies on A. hadrus need to be performed. We integrated 527 high-quality public A...
March 12, 2024: MSphere
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