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JOURNAL ARTICLE
Dionysios Tafiadis, Vasiliki Zarokanellou, Alexandra Prentza, Louiza Voniati, Nafsika Ziavra
BACKGROUND: Diadochokinetic rates tasks are frequently used for the assessment of diadochokinesia (DKK) in young and elderly adults. However, there is scarce research on healthy elderly adults over 65 years old, and little is known about the effect of different types of stimuli (non-words/real words) in this specific population. Furthermore, the current research supports significant language variations, highlighting the need for language-specific norms. AIMS: To investigate the effect of age, gender and type of stimuli (non-words versus real words) in DDK rates in healthy elderly adults of over 65 years of age, and to provide normative data for the Greek language...
June 15, 2022: International Journal of Language & Communication Disorders
#22
JOURNAL ARTICLE
Antoine Bessou, Xavier Colin, Julie De Nascimento, Will Sopwith, Shannon Ferrante, Boris Gorsh, Benjamin Gutierrez, Leah Sansbury, Jenny Willson, Sandhya Sapra, Prani Paka, Feng Wang
BACKGROUND: Real-world data on health care resource utilisation (HCRU) and costs for French patients with multiple myeloma (MM) are limited due to the quickly evolving MM treatment landscape. This retrospective, national-level study quantified the MM economic burden in France. METHODS: The study included patients with newly diagnosed MM from the Système National des Données de Santé coverage claims database between 2013 and 2018 who received active treatment within 30 days of diagnosis...
May 25, 2022: European Journal of Health Economics: HEPAC: Health Economics in Prevention and Care
#23
JOURNAL ARTICLE
Li Jun Thean, Lucia Romani, Daniel Engelman, Handan Wand, Adam Jenney, Jyotishna Mani, Jessica Paka, Tuliana Cua, Sera Taole, Maciu Silai, Komal Ashwini, Aalisha Sahukhan, Mike Kama, Meciusela Tuicakau, Joseph Kado, Matthew Parnaby, Natalie Carvalho, Margot Whitfeld, John Kaldor, Andrew C Steer
Background: Scabies is an important predisposing factor of impetigo which can lead to serious bacterial complications. Ivermectin-based mass drug administration can substantially reduce scabies and impetigo prevalence in endemic settings, but the impact on serious bacterial complications is not known. Methods: We conducted a before-after trial in the Northern Division of Fiji (population: 131,914) of mass drug administration for scabies control. Prospective surveillance was conducted from 2018 to 2020...
May 2022: The Lancet Regional Health. Western Pacific
#24
JOURNAL ARTICLE
Pavan K Paka, Maan El Halabi, Oluwasayo Adeyemo, Michael S Smith, Edward Lung, Priya Simoes
No abstract text is available yet for this article.
January 2022: ACG Case Reports Journal
#25
JOURNAL ARTICLE
A S Mokhtar, M Muslimin, A Y Mat-Saat, A-R M Ghazali, A K Ismail, N M Abdul-Aziz
We report two confirmed human bite cases by Lactrodectus geometricus , also known as the brown widow spider. These are the first reported bite envenomation incidents by L. geometricus in Malaysia. The incidents occurred in Tawau, Sabah and Paka, Terengganu. Both men were bitten on their ear while putting on motorcycle helmets. The spiders appeared to have nested in the helmets. The dead specimens were collected and sent to the Invertebrate and Vertebrate Neurobiology Laboratory, Department of Parasitology, Universiti Malaya for identification...
December 1, 2021: Tropical Biomedicine
#26
REVIEW
Anna M Wulf, Marcela M Moreno, Chloé Paka, Alexandra Rampasekova, Karen J Liu
Neuroblastoma is a common extracranial solid tumour of childhood, responsible for 15% of cancer-related deaths in children. Prognoses vary from spontaneous remission to aggressive disease with extensive metastases, where treatment is challenging. Tumours are thought to arise from sympathoadrenal progenitor cells, which derive from an embryonic cell population called neural crest cells that give rise to diverse cell types, such as facial bone and cartilage, pigmented cells, and neurons. Tumours are found associated with mature derivatives of neural crest, such as the adrenal medulla or paraspinal ganglia...
October 29, 2021: International Journal of Molecular Sciences
#27
Ashwin Jayaram Shetty, K M Sweta, P Bhat Ramesh
Management of burn injury is a challenging task as it can lead to considerable amount of agony and disability to the victims. An estimated annual burn incidence in India is 6-7 million. Depending on the degree of burn or the thickness of skin involved, the healing period will vary from 1 to 3 weeks. The aims of dressing in burn injury are to decrease the agony from pain in the wound, to protect or isolate the burn wound from the irritation caused by the dress worn and external environment, and to the hasten the healing of the wound...
August 3, 2021: Journal of Ayurveda and Integrative Medicine
#28
JOURNAL ARTICLE
Rana A A M Al-Mohana, Fenik Kaml Muhammed, Xiaoguang Li, Grace Paka Lubamba
OBJECTIVE: This study aimed to evaluate and compare sizes, shapes and bridging of the sella turcica (ST) in Yemeni individuals with different skeletal patterns, genders, and ages, and to assess the association between the linear dimension of ST and gender, age, or skeletal patterns. The standard anatomical structure of ST among Yemeni subjects is still unknown and this study can be considered as the first reference regarding ST of Yemeni individuals. MATERIALS AND METHODS: Cephalogram images for 234 subjects (167 females and 67 males) were traced and classified for groups by gender, age, and dentofacial skeletal patterns...
June 18, 2021: Oral Radiology
#29
JOURNAL ARTICLE
Md Istiaq Obaidi Tanvir, Go Itoh, Hiroyuki Adachi, Shigehiko Yumura
Wound repair of cell membranes is essential for cell survival. Myosin II contributes to wound pore closure by interacting with actin filaments in larger cells; however, its role in smaller cells is unclear. In this study, we observed wound repair in dividing cells for the first time. The cell membrane in the cleavage furrow, where myosin II localized, was wounded by laserporation. Upon wounding, actin transiently accumulated, and myosin II transiently disappeared from the wound site. Ca2+ influx from the external medium triggered both actin and myosin II dynamics...
May 17, 2021: Cells
#30
JOURNAL ARTICLE
Li Jun Thean, Lucia Romani, Daniel Engelman, Adam Jenney, Handan Wand, Jyotishna Mani, Jessica Paka, Rachel Devi, Aalisha Sahukhan, Mike Kama, Meciusela Tuicakau, Joseph Kado, Natalie Carvalho, Margot Whitfeld, John Kaldor, Andrew C Steer
Scabies, impetigo, and other skin and soft tissue infections (SSTIs) are highly prevalent in many tropical, low-middle income settings, but information regarding their burden of disease is scarce. We conducted a surveillance of presentations of scabies and SSTIs, including impetigo, abscesses, cellulitis, and severe SSTI, to primary health facilities in Fiji. We established a monthly reporting system over the course of 50 weeks (July 2018-June 2019) for scabies and SSTIs at all 42 public primary health facilities in the Northern Division of Fiji (population, ≈131,914)...
May 24, 2021: American Journal of Tropical Medicine and Hygiene
#31
JOURNAL ARTICLE
Li Jun Thean, Adam Jenney, Daniel Engelman, Lucia Romani, Handan Wand, Jyotishna Mani, Jessica Paka, Tuliana Cua, Sera Taole, Vika Soqo, Aalisha Sahukhan, Mike Kama, Meciusela Tuicakau, Joseph Kado, Natalie Carvalho, Margot Whitfeld, John Kaldor, Andrew C Steer
BACKGROUND: Invasive Staphylococcus aureus (iSA) and group A Streptococcus (iGAS) infections impose significant health burdens globally. Both bacteria commonly cause skin and soft tissue infection (SSTI), which can result in invasive disease. Understanding of iSA and iGAS incidence remains limited in settings with high SSTI burden. METHODS: Prospective surveillance for admissions with iSA or iGAS was conducted at the referral hospital in Fiji's Northern Division over 48 weeks between July 2018-June 2019...
May 19, 2021: International Journal of Infectious Diseases: IJID
#32
JOURNAL ARTICLE
Placide Mbala-Kingebeni, Catherine Pratt, Mbusa Mutafali-Ruffin, Matthias G Pauthner, Faustin Bile, Antoine Nkuba-Ndaye, Allison Black, Eddy Kinganda-Lusamaki, Martin Faye, Amuri Aziza, Moussa M Diagne, Daniel Mukadi, Bailey White, James Hadfield, Karthik Gangavarapu, Nella Bisento, Donatien Kazadi, Bibiche Nsunda, Marceline Akonga, Olivier Tshiani, John Misasi, Aurelie Ploquin, Victor Epaso, Emilia Sana-Paka, Yannick Tutu Tshia N'kasar, Fabrice Mambu, Francois Edidi, Meris Matondo, Junior Bula Bula, Boubacar Diallo, Mory Keita, Marie R D Belizaire, Ibrahima S Fall, Abdoulaye Yam, Sabue Mulangu, Anne W Rimion, Elias Salfati, Ali Torkamani, Marc A Suchard, Ian Crozier, Lisa Hensley, Andrew Rambaut, Ousmane Faye, Amadou Sall, Nancy J Sullivan, Trevor Bedford, Kristian G Andersen, Michael R Wiley, Steve Ahuka-Mundeke, Jean-Jacques Muyembe Tamfum
During the 2018-2020 Ebola virus disease (EVD) outbreak in North Kivu province in the Democratic Republic of Congo, EVD was diagnosed in a patient who had received the recombinant vesicular stomatitis virus-based vaccine expressing a ZEBOV glycoprotein (rVSV-ZEBOV) (Merck). His treatment included an Ebola virus (EBOV)-specific monoclonal antibody (mAb114), and he recovered within 14 days. However, 6 months later, he presented again with severe EVD-like illness and EBOV viremia, and he died. We initiated epidemiologic and genomic investigations that showed that the patient had had a relapse of acute EVD that led to a transmission chain resulting in 91 cases across six health zones over 4 months...
April 1, 2021: New England Journal of Medicine
#33
JOURNAL ARTICLE
Li Jun Thean, Adam Jenney, Daniel Engelman, Lucia Romani, Handan Wand, Jyotishna Mudaliar, Jessica Paka, Tuliana Cua, Sera Taole, Aalisha Sahukhan, Mike Kama, Meciusela Tuicakau, Joseph Kado, Natalie Carvalho, Margot Whitfeld, John Kaldor, Andrew C Steer
Scabies is an important predisposing factor for impetigo but its role in more serious skin and soft tissue infections (SSTIs) is not well understood. Information is limited on incidence of SSTIs in the presence of endemic scabies. We conducted a prospective study of hospital admissions for SSTIs in the Northern Division of Fiji (population: 131,914). Prospective surveillance for admissions with impetigo, abscess, cellulitis, wound infection, pyomyositis, necrotizing fasciitis, infected scabies, and crusted scabies was conducted at the Division's referral hospital between 2018 to 2019...
December 2020: PLoS Neglected Tropical Diseases
#34
JOURNAL ARTICLE
Ben L Da, Tatyana Kushner, Maan El Halabi, Pavan Paka, Mian Khalid, Angad Uberoi, Brian T Lee, Ponni V Perumalswami, Stephanie M Rutledge, Thomas D Schiano, Scott Friedman, Behnam Saberi
Background: Liver injury is commonly seen in coronavirus disease 2019 (COVID-19). However, the mechanism behind liver injury, particularly in severe and critical COVID-19 patients, remains unclear and the clinical course is poorly described. Methods: We conducted a single-center, retrospective cohort study of consecutive hospitalized severe and critically ill COVID-19 patients with or without liver injury who underwent immunologic testing (IL-6, IL-8, TNF-α, and IL-1ß)...
October 16, 2020: Hepatology Communications
#35
JOURNAL ARTICLE
Jaromir Jakacki, Jan Andrzejewski, Anna Przyborska, Maciej Muzyka, Diana Gordon, Jakub Nawała, Stanisław Popiel, Maria Golenko, Victor Zhurbas, Vadim Paka
The leakage of any substances at the sea bottom consequently leads to contamination. The polluted area will strongly depend on the type of pollution which can be dissolved, material and the physical state of the bottom layers. Although the systems that monitor the particles or pollution on the sea surface already exists, there is no similar tool for the bottom area. This work aims at developing the High Resolution Dispersion Model (HRDM) that calculates transport of the pollution in case of potential leakage from chemical ammunition dumped into the Baltic Sea...
August 4, 2020: Marine Environmental Research
#36
JOURNAL ARTICLE
Adriana Oliveira Manfiolli, Eliciane Cevolani Mattos, Leandro José de Assis, Lilian Pereira Silva, Mevlüt Ulaş, Neil Andrew Brown, Rafael Silva-Rocha, Özgür Bayram, Gustavo H Goldman
Aspergillus fumigatus , a saprophytic filamentous fungus, is a serious opportunistic pathogen of mammals and it is the primary causal agent of invasive aspergillosis (IA). Mitogen activated protein Kinases (MAPKs) are important components involved in diverse cellular processes in eukaryotes. A. fumigatus MpkC and SakA, the homologs of the Saccharomyces cerevisiae Hog1 are important to adaptations to oxidative and osmotic stresses, heat shock, cell wall damage, macrophage recognition, and full virulence. We performed protein pull-down experiments aiming to identify interaction partners of SakA and MpkC by mass spectrometry analysis...
2019: Frontiers in Microbiology
#37
JOURNAL ARTICLE
Chandhana Paka, Jennifer L Hallock, Bruce Trock, Kimberley Steele, E James Wright
OBJECTIVE: The objective of this study was to assess whether patients seeking bariatric surgery were at least as proficient in urinary incontinence (UI) and pelvic organ prolapse (POP) knowledge as the general population. Our secondary objective was to determine care-seeking and impact of embarrassment on knowledge of pelvic floor disorders (PFDs). METHODS: An anonymous survey was administered to adult women who attended a bariatric surgery information session from May 2015 to January 2016...
January 11, 2019: Female Pelvic Medicine & Reconstructive Surgery
#38
JOURNAL ARTICLE
Dasom Cheon, Woo Cheol Lee, Yeongjoon Lee, Jee-Young Lee, Yangmee Kim
Propionibacterium acnes is an anaerobic gram-positive bacterium found in the niche of the sebaceous glands in the human skin, and is a causal pathogen of inflammatory skin diseases as well as periprosthetic joint infection. To gain effective control of P. acnes, a deeper understanding of the cellular metabolism mechanism involved in its ability to reside in this unique environment is needed. P. acnes exhibits typical cell membrane features of gram-positive bacteria, such as control of membrane fluidity by branched-chain fatty acids (BCFAs)...
December 23, 2018: Biochemical and Biophysical Research Communications
#39
JOURNAL ARTICLE
Eriston V Gomes, Julio C Bortolossi, Pablo R Sanches, Niege S Mendes, Nilce M Martinez-Rossi, Antonio Rossi
Signaling pathways are highly diverse in filamentous fungi, allowing the cells to receive and process ambient information. Interaction of components from different pathways results in signaling networks. The mitogen-activated protein kinase (MAPK) pathway is dependent on phosphorylation that is accomplished by kinase proteins. Thus, the STE/PAK protein kinase family plays essential roles in MAPK signal transduction, regulating several cellular functions. The STE/PAK protein displays an autoinhibitory (Cdc42/Rac interactive binding-CRIB) domain on its N-terminal portion, which interacts with the C-terminal catalytic kinase domain...
November 20, 2018: International Journal of Molecular Sciences
#40
JOURNAL ARTICLE
Sandra Giuliani, Arthur C Silva, Joyce V V B Borba, Pablo I P Ramos, Ross A Paveley, Eugene N Muratov, Carolina Horta Andrade, Nicholas Furnham
The development of novel therapeutics is urgently required for diseases where existing treatments are failing due to the emergence of resistance. This is particularly pertinent for parasitic infections of the tropics and sub-tropics, referred to collectively as neglected tropical diseases, where the commercial incentives to develop new drugs are weak. One such disease is schistosomiasis, a highly prevalent acute and chronic condition caused by a parasitic helminth infection, with three species of the genus Schistosoma infecting humans...
October 2018: PLoS Computational Biology
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