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Chandhana Paka, Ixora Kamisan Atan, Rebeca Rios, Hans Peter Dietz
OBJECTIVE: The aim of this study was to investigate the association of the anatomic integrity of the external anal sphincter (EAS) detected on transperineal ultrasound (TPUS) with symptoms of anal incontinence (AI) as measured by St Mark's Incontinence Score (SMIS) and the visual analog scale (VAS). METHODS: This is an observational, cross-sectional analysis of 486 women who presented to a tertiary urogynecological center between May 2013 and August 2014. They underwent a standardized interview and an examination that involved 3-dimensional/4-dimensional TPUS...
October 25, 2016: Female Pelvic Medicine & Reconstructive Surgery
Ghislain Djiokeng Paka, Charles Ramassamy
One major challenge in the field of nanotherapeutics is to increase the selective delivery of cargo to targeted cells. Using Poly Lactic-co-Glycolic Acid (PLGA), we recently highlighted the importance of polymer composition in the biological fate of the nanodrug delivery systems. However the route of internalisation of polymeric nanoparticles (NPs) is another key component to consider in the elaboration of modern and targeted devices. For that purpose, herein, we effectively synthesized and characterised glutathione- functionalized PLGA-nanoparticles (GSH-NPs) loaded with curcumin (GSH-NPs-Cur), using thiol-maleimide click reaction and determined their physicochemical properties...
October 15, 2016: Molecular Pharmaceutics
L Thomaier, M Abernethy, C Paka, Ccg Chen
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
Ruchir Gupta, Nadia Sunny, Sabrina L Noyes, Mouafak Tourojman, Bikal Paka, Robert Bossemeyer, Brian R Lane
PURPOSE: To determine the functional life of various configurations of partial nephrectomy (PN) closure systems. MATERIALS AND METHODS: Sutures were prepared using standard techniques for sutured renorrhaphy during PN. Tested systems included Knot-Hem-o-Lok® (K-H), Lapra-Ty-Hem-o-Lok® (L-H), and Hem-o-Lok®-Hem-o-Lok® (H-H) combinations. The saline-filled tank was maintained at 37°C and sutures (Vicryl, Stratafix® PGA-PCL, V-Loc(TM)180) were suspended at 4N or 2N...
July 11, 2016: Journal of Urology
Prakash Narayan, Bin Duan, Kai Jiang, Jingsong Li, Latha Paka, Michael A Yamin, Scott L Friedman, Matthew R Weir, Itzhak D Goldberg
Ischemia-reperfusion-mediated acute kidney injury can necessitate renal replacement therapy and is a major cause of morbidity and mortality. We have identified BB3, a small molecule, which when first administered at 24 h after renal ischemia in rats, improved survival, augmented urine output, and reduced the increase in serum creatinine and blood urea nitrogen. Compared with control kidneys, the kidneys of BB3-treated animals exhibited reduced levels of kidney injury molecule-1, neutrophil gelatinase-associated lipocalin, and reduced tubular apoptosis and acute tubular necrosis but enhanced tubular regeneration...
August 1, 2016: American Journal of Physiology. Renal Physiology
P D H Wall, A P Sprowson, N Parsons, H Parsons, J Achten, S Balasubramanian, M L Costa
INTRODUCTION: Total knee arthroplasty (TKA) surgery causes postoperative pain. The use of perioperative injections around the knee containing local anaesthetic, opiates and non-steroidal anti-inflammatory drugs has increased in popularity to manage pain. Theoretical advantages include reduced requirements for analgesia and earlier mobilisation. We propose a single-centre randomised controlled trial of multimodal periarticular anaesthetic infiltration versus femoral nerve anaesthetic blockade as analgesia for TKA...
2015: BMJ Open
Prabhakar Vardhan, Kartar Singh Dhiman
BACKGROUND: Dry eye syndrome (DES) is a common ophthalmic problem predominantly affecting middle-aged and elderly people. It is a disease of deficient or deranged tears and ocular surface disorder producing symptoms of discomfort, visual disturbance, and tears film instability. Shushkakshipaka, an etymologically and clinically similar entity to DES, is defined in Ayurveda as the disease affecting all parts of the eye characterized by Paka (inflammation) due to Shuskatva (dryness) caused by altered coherence of Ashru (tears) with ocular surface or due to lack of Ashru...
July 2014: Ayu
Ghislain Djiokeng Paka, Sihem Doggui, Ahlem Zaghmi, Ramia Safar, Lé Dao, Andreas Reisch, Andrey Klymchenko, V Gaëlle Roullin, Olivier Joubert, Charles Ramassamy
Curcumin, a neuroprotective agent with promising therapeutic approach has poor brain bioavailability. Herein, we demonstrate that curcumin-encapsulated poly(lactide-co-glycolide) (PLGA) 50:50 nanoparticles (NPs-Cur 50:50) are able to prevent the phosphorylation of Akt and Tau proteins in SK-N-SH cells induced by H2O2 and display higher anti-inflammatory and antioxidant activities than free curcumin. PLGA can display various physicochemical and degradation characteristics for controlled drug release applications according to the matrix used...
February 1, 2016: Molecular Pharmaceutics
C Paka, I K Atan, H P Dietz
BACKGROUND: Patient self-report is important in the assessment of the impact of anal incontinence (AI) on quality of life. This study aimed to (1) determine the correlation between total St. Mark's Incontinence Score (SMIS) and a single-item visual analogue scale (VAS) for bother from AI, and (2) determine the correlation between individual components of SMIS and VAS. METHODS: This is a retrospective study conducted on a cohort of 516 women seen for symptoms of lower urinary tract and pelvic floor dysfunction between January 2013 and August 2014...
February 2016: Techniques in Coloproctology
K Mitrakul, Y Asvanund, M Arunakul, S Paka-Akekaphat
AIM: To evaluate the effect of Audiovisual (AV) eyeglasses on pain and anxiety levels during restorative treatment in 5-8 year-olds Thai children. MATERIALS AND METHODS: HASH(0x39c9020) STUDY DESIGN: Forty-two children with bilateral carious molars were recruited and randomly divided into 2 groups according to the sequence of AV eyeglasses used. Group I was a group which received treatment without wearing AV eyeglasses in the first visit and wearing the eyeglasses in a second visit...
September 2015: European Journal of Paediatric Dentistry: Official Journal of European Academy of Paediatric Dentistry
Karthic Swaminathan, Maria Stumpf, Rolf Müller, Anna-Carolin Horn, Julia Schmidbauer, Ludwig Eichinger, Annette Müller-Taubenberger, Jan Faix, Angelika A Noegel
Coronin7 (CRN7) stabilizes F-actin and is a regulator of processes associated with the actin cytoskeleton. Its loss leads to defects in phagocytosis, motility and development. It harbors a CRIB (Cdc42- and Rac-interactive binding) domain in each of its WD repeat domains which bind to Rac GTPases preferably in their GDP-loaded forms. Expression of wild type CRN7 in CRN7 deficient cells rescued these defects, whereas proteins with mutations in the CRIB motifs which were associated with altered Rac binding were effective to varying degrees...
2015: Scientific Reports
Jean-Michel Rabanel, Jimmy Faivre, Ghislain Djiokeng Paka, Charles Ramassamy, Patrice Hildgen, Xavier Banquy
We developed a nanoparticles (NPs) library from poly(ethylene glycol)-poly lactic acid comb-like polymers with variable amount of PEG. Curcumin was encapsulated in the NPs with a view to develop a delivery platform to treat diseases involving oxidative stress affecting the CNS. We observed a sharp decrease in size between 15 and 20% w/w of PEG which corresponds to a transition from a large solid particle structure to a "micelle-like" or "polymer nano-aggregate" structure. Drug loading, loading efficacy and release kinetics were determined...
October 2015: European Journal of Pharmaceutics and Biopharmaceutics
Harvey Schwartz, Brad Scroggins, Abbey Zuehlke, Toshiki Kijima, Kristin Beebe, Alok Mishra, Len Neckers, Thomas Prince
The merging of knowledge from genomics, cellular signal transduction and molecular evolution is producing new paradigms of cancer analysis. Protein kinases have long been understood to initiate and promote malignant cell growth and targeting kinases to fight cancer has been a major strategy within the pharmaceutical industry for over two decades. Despite the initial success of kinase inhibitors (KIs), the ability of cancer to evolve resistance and reprogram oncogenic signaling networks has reduced the efficacy of kinase targeting...
September 2015: Cell Stress & Chaperones
Andreas Kaczmarczyk, Ramon Hochstrasser, Julia A Vorholt, Anne Francez-Charlot
UNLABELLED: The general stress response (GSR) allows bacteria to monitor and defend against a broad set of unrelated, adverse environmental conditions. In Alphaproteobacteria, the key step in GSR activation is phosphorylation of the response regulator PhyR. In Sphingomonas melonis Fr1, seven PhyR-activating kinases (Paks), PakA to PakG, are thought to directly phosphorylate PhyR under different stress conditions, but the nature of the activating signals remains obscure. PakF, a major sensor of NaCl and heat shock, lacks a putative sensor domain but instead harbors a single receiver (REC) domain (PakFREC) N-terminal to its kinase catalytic core...
April 2015: Journal of Bacteriology
Andreas Kaczmarczyk, Ramon Hochstrasser, Julia A Vorholt, Anne Francez-Charlot
The general stress response (GSR) in Alphaproteobacteria was recently shown to be controlled by a partner-switching mechanism that is triggered by phosphorylation of the response regulator PhyR. Activation of PhyR ultimately results in release of the alternative extracytoplasmic function sigma factor σ(EcfG), which redirects transcription toward the GSR. Little is known about the signal transduction pathway(s) controlling PhyR phosphorylation. Here, we identified the single-domain response regulator (SDRR) SdrG and seven histidine kinases, PakA to PakG, belonging to the HWE/HisKA2 family as positive modulators of the GSR in Sphingomonas melonis Fr1...
December 2, 2014: Proceedings of the National Academy of Sciences of the United States of America
Camran Nezhat, Jillian Main, Chandhana Paka, Azadeh Nezhat, Ramin E Beygui
BACKGROUND AND OBJECTIVES: Thoracic endometriosis is a rare form of extragenital endometriosis with important clinical ramifications. Up to 80% of women with thoracic endometriosis have concomitant abdominopelvic endometriosis, yet the surgical treatment is usually performed with separate procedures. This is the largest published series of the combination of video-assisted thoracoscopic surgery and traditional laparoscopy for the treatment of abdominopelvic and thoracic endometriosis...
July 2014: JSLS: Journal of the Society of Laparoendoscopic Surgeons
Camran Nezhat, Jillian Main, Chandhana Paka, Rose Soliemannjad, M Ali Parsa
BACKGROUND/OBJECTIVES: It has been shown that major gynecologic laparoscopy is safe in hospital ambulatory settings, but there is little data to suggest the same in freestanding ambulatory surgery centers. This study evaluates the safety and efficacy of advanced gynecologic laparoscopic surgery using a fast-track model in freestanding ambulatory surgery centers and discusses our institution protocols. METHODS: Retrospective, multicenter review was conducted of major gynecologic surgeries from August 1st 2010 to September 30th 2011 in 3 surgical centers with one primary surgeon...
July 2014: JSLS: Journal of the Society of Laparoendoscopic Surgeons
Jingmin Ji, Melanie L Hassler, Etsuko Shimobayashi, Nagendher Paka, Raphael Streit, Josef P Kapfhammer
Spinocerebellar ataxias (SCAs) are hereditary diseases leading to Purkinje cell degeneration and cerebellar dysfunction. Most forms of SCA are caused by expansion of CAG repeats similar to other polyglutamine disorders such as Huntington's disease. In contrast, in the autosomal dominant SCA-14 the disease is caused by mutations in the protein kinase C gamma (PKCγ) gene which is a well characterized signaling molecule in cerebellar Purkinje cells. The study of SCA-14, therefore, offers the unique opportunity to reveal the molecular and pathological mechanism eventually leading to Purkinje cell dysfunction and degeneration...
October 2014: Neurobiology of Disease
Nikhil M Jirankalgikar, Pankaj B Nariya, Arun V Athavale, Subrata De
BACKGORUND: The three stages of Snehapaka formulations namely Mridu, Madhyama and Khara Paka have been characteristically advocated for different routes of administration-Nasya, Pana/Basti and Abhyanga, respectively. Guidelines or established method for post-formulation characterization for the same is hardly available. OBJECTIVE: The present communication is the comparative study of Mridu, Madhyama and Khara Paka of Panchagavya ghrita (PGG). MATERIALS AND METHODS: Laboratory prepared samples of PGG following classical method were analyzed for different physicochemical, spectroscopic, chromatographic parameters, and antioxidant activity...
April 2013: Journal of Ayurveda and Integrative Medicine
Sihem Doggui, Abdenour Belkacemi, Ghislain Djiokeng Paka, Morgane Perrotte, Rongbiao Pi, Charles Ramassamy
SCOPE: The aim of the present study was to examine the neuroprotective effect of curcumin against the toxicity induced by acrolein and to identify its cellular mechanisms and targets. METHODS AND RESULTS: Human neuroblastoma cells SK-N-SH were treated with acrolein. Curcumin, from 5 μM, was able to protect SK-N-SH cells against acrolein toxicity. The addition of curcumin restored the expression of γ-glutamylcysteine synthetase, reactive oxygen species, and reactive nitrogen species levels but had no effect on the decrease of glutathione (GSH) and on the elevation of protein carbonyls...
September 2013: Molecular Nutrition & Food Research
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