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Jake A Nieto, Janice Zhu, Bin Duan, Jingsong Li, Ping Zhou, Latha Paka, Michael A Yamin, Itzhak D Goldberg, Prakash Narayan
The extent of scarring or renal interstitial collagen deposition in chronic kidney disease (CKD) can only be ascertained by highly invasive, painful and sometimes risky, tissue biopsy. Interestingly, while CKD-related abnormalities in kidney size can often be visualized using ultrasound, not only does the ellipsoid formula used today underestimate true renal size, but the calculated renal size does not inform tubulointerstitial collagen content. We used coronal kidney sections from healthy mice and mice with kidney disease to develop a new formula for estimating renal parenchymal area...
2018: PloS One
Max Ruas, V Guignon, G Sempere, J Sardos, Y Hueber, H Duvergey, A Andrieu, R Chase, C Jenny, T Hazekamp, B Irish, K Jelali, J Adeka, T Ayala-Silva, C P Chao, J Daniells, B Dowiya, B Effa Effa, L Gueco, L Herradura, L Ibobondji, E Kempenaers, J Kilangi, S Muhangi, P Ngo Xuan, J Paofa, C Pavis, D Thiemele, C Tossou, J Sandoval, A Sutanto, G Vangu Paka, G Yi, I Van den Houwe, N Roux, M Rouard
January 1, 2017: Database: the Journal of Biological Databases and Curation
(no author information available yet)
Wall PDH, Parsons NR, Parsons H, Achten J, Balasubramanian S, Thompson P, Costa ML; P. D. H. Wall on behalf of A. P. Sprowson,† M. L. Costa, PAKA Study Group. A pragmatic randomised controlled trial comparing the efficacy of a femoral nerve block and periarticular infiltration for early pain relief following total knee arthroplasty. Bone Joint J 2017;99-B:904-911.
December 2017: Bone & Joint Journal
Nivedita Dube, Chetan Nimgulkar, Dinesh Kumar Bharatraj
Arjuna Ksheera Paka (AKP), a traditional Ayurvedic formulation of Terminalia arjuna ( T . arjuna ) bark powder is used for its cardioprotective effects. However, its anti-inflammatory efficacy remained unexplored. In the present study, AKP was prepared in cow milk (as per standard Ayurvedic procedure) and compared with standard hydroalcoholic extract (HA) of T . arjuna . The extracts were analyzed for gross phytoconstituents levels, and their antioxidant activity was assayed by DPPH free radical scavenging activity and inhibition of lipid peroxidation...
October 2017: Journal of Traditional and Complementary Medicine
Latha Paka, David E Smith, Dawoon Jung, Siobhan McCormack, Ping Zhou, Bin Duan, Jing-Song Li, Jiaqi Shi, Yong-Jie Hao, Kai Jiang, Michael Yamin, Itzhak D Goldberg, Prakash Narayan
AIM: To evaluate a calcium activated potassium channel (KCa3.1) inhibitor attenuates liver disease in models of non-alcoholic fatty liver disease (NAFLD). METHODS: We have performed a series of in vitro and in vivo studies using the KCa3.1 channel inhibitor, Senicapoc. Efficacy studies of Senicapoc were conducted in toxin-, thioacetamide (TAA) and high fat diet (HFD)-induced models of liver fibrosis in rats. Efficacy and pharmacodynamic effects of Senicapoc was determined through biomarkers of apoptosis, inflammation, steatosis and fibrosis...
June 21, 2017: World Journal of Gastroenterology: WJG
P D H Wall, N R Parsons, H Parsons, J Achten, S Balasubramanian, P Thompson, M L Costa
AIMS: The aim of this study was to compare the effectiveness of a femoral nerve block and a periarticular infiltration in the management of early post-operative pain after total knee arthroplasty (TKA). PATIENTS AND METHODS: A pragmatic, single centre, two arm parallel group, patient blinded, randomised controlled trial was undertaken. All patients due for TKA were eligible. Exclusion criteria included contraindications to the medications involved in the study and patients with a neurological abnormality of the lower limb...
July 2017: Bone & Joint Journal
Bikal Paka, Robert Bossemeyer, Mouafak Tourojman, Ruchir Gupta, Brian R Lane
OBJECTIVE: To investigate the anti-slip strength of closing systems employing sutures terminated with a Hem-o-lok/Lapra-Ty clip combination to determine which sutures perform best for this application. Partial nephrectomy is the reference standard for treatment of small renal masses. The main disadvantage of partial nephrectomy is the risk of technical complications, including renorrhaphy site bleeding and urine leak. MATERIALS AND METHODS: A materials testing system produced a constant velocity pull on the free end of an anchored suture...
June 23, 2017: Urology
Sarvesh Kumar Singh, Kshipra Rajoria
The age related spondylotic changes may result in direct compressive and ischemic dysfunction of the spinal cord known as cervical spondylotic myelopathy (CSM). Symptoms often develop insidiously and are characterized by neck stiffness, unilateral or bilateral deep aching neck, arm and shoulder pain, and possibly stiffness or clumsiness while walking. The management available in current mainstream medicine is not satisfactory. Various Ayurvedic treatments have been in use for these manifestations. We present a case of CSM, which was treated with a combination of Panchakarma procedures and Ayurvedic oral drugs...
January 2017: Journal of Ayurveda and Integrative Medicine
Alexandra Foscolou, Evangelos Polychronopoulos, Efstratia Paka, Stefanos Tyrovolas, Vassiliki Bountziouka, Akis Zeimbekis, Dimitra Tyrovola, Dilek Ural, Demosthenes Panagiotakos
OBJECTIVE: The aim of the present study was to evaluate lifestyle and health determinants of cardiovascular disease (CVD) risk among Greek elderly residents living in Eastern Aegean islands, in both Greece and Turkey. METHODS: Under the context of the MEDIS study, 724 older adults (aged 65 to 100 years) from 8 Eastern Aegean Sea Greek islands (n=100 living in Samothrace, 142 in Lesvos, 150 in Limnos, 76 in Ikaria, 52 in Kassos, 149 in Rhodes and Karpathos) and from Turkey (n=55older adults of Greek origin living on Gökçeada Island) were voluntarily recruited...
November 2016: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
Lauren Thomaier, Megan Orlando, Melinda Abernethy, Chandhana Paka, Chi Chiung Grace Chen
BACKGROUND: Although surgical simulation provides an effective supplement to traditional training, it is not known whether skills are transferable between minimally invasive surgical modalities. The purpose of this study was to assess the transferability of skills between minimally invasive surgical simulation platforms among simulation-naïve participants. METHODS: Forty simulation-naïve medical students were enrolled in this randomized single-blinded controlled trial...
August 2017: Surgical Endoscopy
Sarvesh Kumar Singh, Kshipra Rajoria
Spondyloepiphyseal dysplasia tarda (SEDT) is a rare genetic disease in which patient suffers from short stature, short trunk and neck with disproportionately long arms, coxa vara, skeletal features such as barrel shaped chest, kyphosis, scoliosis and early arthropathy. Only limited medical and surgical management is available in modern medicine. A 15 years old male suffering from SEDT and diagnosed as Vata vyadhi was treated with Panchakarma therapy and selected Ayurvedic oral medicines. Ayurvedic treatment was directed to ameliorate the orthopaedic clinical conditions in this case...
October 2016: Journal of Ayurveda and Integrative Medicine
Chandhana Paka, Ixora Kamisan Atan, Rebeca Rios, Hans Peter Dietz
OBJECTIVE: The aim of this study was to investigate the association of the anatomic integrity of the external anal sphincter (EAS) detected on transperineal ultrasound (TPUS) with symptoms of anal incontinence (AI) as measured by St Mark's Incontinence Score (SMIS) and the visual analog scale (VAS). METHODS: This is an observational, cross-sectional analysis of 486 women who presented to a tertiary urogynecological center between May 2013 and August 2014. They underwent a standardized interview and an examination that involved 3-dimensional/4-dimensional TPUS...
July 2017: Female Pelvic Medicine & Reconstructive Surgery
Ghislain Djiokeng Paka, Charles Ramassamy
One major challenge in the field of nanotherapeutics is to increase the selective delivery of cargo to targeted cells. Using polylactic-co-glycolic acid (PLGA), we recently highlighted the importance of polymer composition in the biological fate of the nanodrug delivery systems. However, the route of internalization of polymeric nanoparticles (NPs) is another key component to consider in the elaboration of modern and targeted devices. For that purpose, herein, we effectively synthesized and characterized glutathione-functionalized PLGA-nanoparticles (GSH-NPs) loaded with curcumin (GSH-NPs-Cur), using thiol-maleimide click reaction and determined their physicochemical properties...
January 3, 2017: Molecular Pharmaceutics
L Thomaier, M Abernethy, C Paka, Ccg Chen
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
Ruchir Gupta, Nadia Sunny, Sabrina L Noyes, Mouafak Tourojman, Bikal Paka, Robert Bossemeyer, Brian R Lane
PURPOSE: To determine the functional life of various configurations of partial nephrectomy (PN) closure systems. MATERIALS AND METHODS: Sutures were prepared using standard techniques for sutured renorrhaphy during PN. Tested systems included Knot-Hem-o-Lok® (K-H), Lapra-Ty-Hem-o-Lok® (L-H), and Hem-o-Lok®-Hem-o-Lok® (H-H) combinations. The saline-filled tank was maintained at 37°C and sutures (Vicryl, Stratafix® PGA-PCL, V-Loc(TM)180) were suspended at 4N or 2N...
July 11, 2016: Journal of Urology
Prakash Narayan, Bin Duan, Kai Jiang, Jingsong Li, Latha Paka, Michael A Yamin, Scott L Friedman, Matthew R Weir, Itzhak D Goldberg
Ischemia-reperfusion-mediated acute kidney injury can necessitate renal replacement therapy and is a major cause of morbidity and mortality. We have identified BB3, a small molecule, which when first administered at 24 h after renal ischemia in rats, improved survival, augmented urine output, and reduced the increase in serum creatinine and blood urea nitrogen. Compared with control kidneys, the kidneys of BB3-treated animals exhibited reduced levels of kidney injury molecule-1, neutrophil gelatinase-associated lipocalin, and reduced tubular apoptosis and acute tubular necrosis but enhanced tubular regeneration...
August 1, 2016: American Journal of Physiology. Renal Physiology
P D H Wall, A P Sprowson, N Parsons, H Parsons, J Achten, S Balasubramanian, M L Costa
INTRODUCTION: Total knee arthroplasty (TKA) surgery causes postoperative pain. The use of perioperative injections around the knee containing local anaesthetic, opiates and non-steroidal anti-inflammatory drugs has increased in popularity to manage pain. Theoretical advantages include reduced requirements for analgesia and earlier mobilisation. We propose a single-centre randomised controlled trial of multimodal periarticular anaesthetic infiltration versus femoral nerve anaesthetic blockade as analgesia for TKA...
December 21, 2015: BMJ Open
Prabhakar Vardhan, Kartar Singh Dhiman
BACKGROUND: Dry eye syndrome (DES) is a common ophthalmic problem predominantly affecting middle-aged and elderly people. It is a disease of deficient or deranged tears and ocular surface disorder producing symptoms of discomfort, visual disturbance, and tears film instability. Shushkakshipaka, an etymologically and clinically similar entity to DES, is defined in Ayurveda as the disease affecting all parts of the eye characterized by Paka (inflammation) due to Shuskatva (dryness) caused by altered coherence of Ashru (tears) with ocular surface or due to lack of Ashru...
July 2014: Ayu
Ghislain Djiokeng Paka, Sihem Doggui, Ahlem Zaghmi, Ramia Safar, Lé Dao, Andreas Reisch, Andrey Klymchenko, V Gaëlle Roullin, Olivier Joubert, Charles Ramassamy
Curcumin, a neuroprotective agent with promising therapeutic approach has poor brain bioavailability. Herein, we demonstrate that curcumin-encapsulated poly(lactide-co-glycolide) (PLGA) 50:50 nanoparticles (NPs-Cur 50:50) are able to prevent the phosphorylation of Akt and Tau proteins in SK-N-SH cells induced by H2O2 and display higher anti-inflammatory and antioxidant activities than free curcumin. PLGA can display various physicochemical and degradation characteristics for controlled drug release applications according to the matrix used...
February 1, 2016: Molecular Pharmaceutics
C Paka, I K Atan, H P Dietz
BACKGROUND: Patient self-report is important in the assessment of the impact of anal incontinence (AI) on quality of life. This study aimed to (1) determine the correlation between total St. Mark's Incontinence Score (SMIS) and a single-item visual analogue scale (VAS) for bother from AI, and (2) determine the correlation between individual components of SMIS and VAS. METHODS: This is a retrospective study conducted on a cohort of 516 women seen for symptoms of lower urinary tract and pelvic floor dysfunction between January 2013 and August 2014...
February 2016: Techniques in Coloproctology
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