Selidji T Agnandji, Mario Recker, Benjamin Mordmüller, Stephan Glöckner, Akim A Adegnika, Bertrand Lell, Lucas Otieno, Walter Otieno, Seth Owusu-Agyei, Kwaku P Asante, Tsiri Agbenyega, Daniel Ansong, Eusebio Macete, Pedro Aide, Hermann Sorgho, Halidou Tinto, Neema Mturi, John P A Lusingu, Samwel Gesase, Irving Hoffman, Nahya Salim Masoud, Charles R Newton, Kalifa Bojang, Gérard Krause, Peter Gottfried Kremsner
BACKGROUND: Malaria is still one of the main reasons for hospitalization in children living in sub-Saharan Africa. Rapid risk-stratification at admission is essential for optimal medical care and improved prognosis. Whereas coma, deep breathing, and, to a lesser degree, severe anaemia are established predictors of malaria-related death, the value of assessing prostration for risk-stratification is less certain. METHODS: Here we used a retrospective multi-centre analysis comprising over 33,000 hospitalised children from four large studies, including two observational studies from the Severe Malaria in African Children (SMAC) network, a randomised controlled treatment study, and the phase-3-clinical RTS,S-malaria vaccine trial, to evaluate known risk factors of mortality and with a specific emphasis on the role of prostration...
July 4, 2023: International Journal of Infectious Diseases: IJID