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malaria disease severity scores

María Jesús Chaparro, Félix Calderón, Pablo Castañeda, Elena Fernández-Alvaro, Raquel Gabarró, Francisco Javier Gamo, María G Gómez-Lorenzo, Julio Martín, Esther Fernández
Malaria remains a major global health problem. In 2015 alone, more than 200 million cases of malaria were reported, and more than 400,000 deaths occurred. Since 2010, emerging resistance to current front-line ACTs (artemisinin combination therapies) has been detected in endemic countries. Therefore, there is an urgency for new therapies based on novel modes of action, able to relieve symptoms as fast as the artemisinins and/or block malaria transmission. During the past few years, the antimalarial community has focused their efforts on phenotypic screening as a pragmatic approach to identify new hits...
April 13, 2018: ACS Infectious Diseases
Matthew B Carson, Cong Liu, Yao Lu, Caiyan Jia, Hui Lu
BACKGROUND: Complex diseases involve many genes, and these genes are often associated with several different illnesses. Disease similarity measurement can be based on shared genotype or phenotype. Quantifying relationships between genes can reveal previously unknown connections and form a reference base for therapy development and drug repurposing. METHODS: Here we introduce a method to measure disease similarity that incorporates the uniqueness of shared genes...
May 24, 2017: BMC Medical Genomics
Spinello Antinori, Alberto Corona, Antonio Castelli, Roberto Rech, Beatrice Borghi, Claudia Giannotti, Riccardo Colombo, Tommaso Fossali, Elisabetta Ballone, Caterina Minari, Andrea Perotti, Paola Bergomi, Laura Galimberti, Laura Milazzo, Davide Ricaboni, Daniele Scorza, Romualdo Grande, Francesco Genderini, Marco Ieri, Ferdinando Raimondi, Emanuele Catena, Massimo Galli, Mario Corbellino
BACKGROUND: Severe imported Plasmodium falciparum malaria is a potentially life-threatening disease with a reported mortality rate of 5-10% when patients are admitted to the Intensive Care Unit. METHODS: To retrospectively review the clinical aspects, the value of severity predictive scores and the management of patients with severe P. falciparum malaria admitted to an ICU in Milano, Italy between January 2010 and December 2015. RESULTS: Twelve patients were included: seven were male and five female with a median age of 43 years...
May 2017: Travel Medicine and Infectious Disease
Katja Wyss, Andreas Wångdahl, Maria Vesterlund, Ulf Hammar, Saduddin Dashti, Pontus Naucler, Anna Färnert
Background: Noncommunicable diseases and obesity are increasing in prevalence globally, also in populations at risk of malaria. We sought to investigate if comorbidity, in terms of chronic diseases and obesity, is associated with severe Plasmodium falciparum malaria. Methods: We performed a retrospective observational study in adults (≥18 years of age) diagnosed with malaria in Sweden between January 1995 and May 2015. We identified cases through the surveillance database at the Public Health Agency of Sweden and reviewed clinical data from 18 hospitals...
September 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Mousumi Datta, Jhuma Biswas, Shyamal Dasgupta, Kaushik Banerjee, Subhendu Choudhury, Sandip Kumar Sengupta, Prakash Das
INTRODUCTION: Malaria occurring in pregnancy is associated with considerable maternal and perinatal morbidity. In India, the problem is compounded by dual parasitological aetiology of Plasmodiumvivax (P.vivax) and Plasmodium falciparum (P.falciparum). AIM: To compare the outcome of infections by P. vivax and P.falciparum species among pregnant women in a hospital setting. MATERIALS AND METHODS: Pregnant women who tested positive for malaria either by microscopy of peripheral blood smear or ELISA test for double antigen were enrolled in the study...
January 2017: Journal of Clinical and Diagnostic Research: JCDR
Mary-Anne Hartley, Alyssa Young, Anh-Minh Tran, Harry Henry Okoni-Williams, Mohamed Suma, Brooke Mancuso, Ahmed Al-Dikhari, Mohamed Faouzi
BACKGROUND: Despite the notoriety of Ebola virus disease (EVD) as one of the world's most deadly infections, EVD has a wide range of outcomes, where asymptomatic infection may be almost as common as fatality. With increasingly sensitive EVD diagnosis, there is a need for more accurate prognostic tools that objectively stratify clinical severity to better allocate limited resources and identify those most in need of intensive treatment. METHODS/PRINCIPAL FINDINGS: This retrospective cohort study analyses the clinical characteristics of 158 EVD(+) patients at the GOAL-Mathaska Ebola Treatment Centre, Sierra Leone...
February 2017: PLoS Neglected Tropical Diseases
Chloe R McDonald, Andrea L Conroy, Michael Hawkes, Robyn E Elphinstone, Joel L Gamble, Kyla Hayford, Sophie Namasopo, Robert O Opoka, W Conrad Liles, Kevin C Kain
BACKGROUND: Malaria remains a leading cause of childhood death and neurologic disability in sub-Saharan Africa. Here, we test the hypothesis that malaria-induced alterations to circulating brain-derived neurotrophic factor (BDNF) are associated with poor clinical outcomes in children with severe malaria. METHODS: We quantified BDNF (by enzyme-linked immunosorbent assay) in plasma samples collected [at presentation (day 1), day 3 and day 14], during a prospective study of Ugandan children admitted to hospital with severe malaria (n = 179)...
February 2017: Pediatric Infectious Disease Journal
Monika Samant, Nidhi Chadha, Anjani K Tiwari, Yasha Hasija
Malaria, a life-threatening blood disease, has been a major concern in the field of healthcare. One of the severe forms of malaria is caused by the parasite Plasmodium falciparum which is initiated through protein interactions of pathogen with the host proteins. It is essential to analyse the protein-protein interactions among the host and pathogen for better understanding of the process and characterizing specific molecular mechanisms involved in pathogen persistence and survival. In this study, a complete protein-protein interaction network of human host and Plasmodium falciparum has been generated by integration of the experimental data and computationally predicting interactions using the interolog method...
2016: International Journal of Medicinal Chemistry
Richard Idro, Angelina Kakooza-Mwesige, Benjamin Asea, Keron Ssebyala, Paul Bangirana, Robert O Opoka, Samson K Lubowa, Margaret Semrud-Clikeman, Chandy C John, Joyce Nalugya
BACKGROUND: Cerebral malaria (CM) and severe malarial anaemia (SMA) are associated with neuro-developmental impairment in African children, but long-term mental health disorders in these children are not well defined. METHODS: A cohort of children previously exposed to CM (n = 173) or SMA (n = 99) had neurologic assessments performed and screening for behaviour difficulties using the Strengths and Difficulties Questionnaire (SDQ) a median of 21 months after the disease episode...
March 31, 2016: Malaria Journal
Phyo Pyae Nyein, Ne Myo Aung, Tint Tint Kyi, Zaw Win Htet, Nicholas M Anstey, Mar Mar Kyi, Josh Hanson
Background.  African children with severe falciparum malaria commonly have concomitant Gram-negative bacteremia, but co-infection has been thought to be relatively rare in adult malaria. Methods.  Adults with a diagnosis of falciparum malaria hospitalized at 4 tertiary referral hospitals in Myanmar had blood cultures collected at admission. The frequency of concomitant bacteremia and the clinical characteristics of the patients, with and without bacteremia, were explored. Results.  Of 67 adults hospitalized with falciparum malaria, 9 (13% [95% confidence interval, 5...
January 2016: Open Forum Infectious Diseases
James R M Hargreaves, Catherine Goodman, Calum Davey, Barbara A Willey, Bilal Iqbal Avan, Joanna Rm Armstrong Schellenberg
Evaluation of strategies to ensure evidence-based, low-cost interventions reach those in need is critical. One approach is to measure the strength, or intensity, with which packages of interventions are delivered, in order to explore the association between implementation strength and public health gains. A recent systematic review suggested methodological guidance was needed. We described the approaches used in three examples of measures of implementation strength in evaluation. These addressed important public health topics with a substantial disease burden in low-and middle-income countries; they involved large-scale implementation; and featured evaluation designs without comparison areas...
September 2016: Health Policy and Planning
Nasim Lowlaavar, Charles P Larson, Elias Kumbakumba, Guohai Zhou, J Mark Ansermino, Joel Singer, Niranjan Kissoon, Hubert Wong, Andrew Ndamira, Jerome Kabakyenga, Julius Kiwanuka, Matthew O Wiens
BACKGROUND: Pediatric hospital mortality from infectious diseases in resource constrained countries remains unacceptably high. Improved methods of risk-stratification can assist in referral decision making and resource allocation. The purpose of this study was to create prediction models for in-hospital mortality among children admitted with suspected infectious diseases. METHODS: This two-site prospective observational study enrolled children between 6 months and 5 years admitted with a proven or suspected infection...
2016: PloS One
Saskia van der Kam, Nuria Salse-Ubach, Stephanie Roll, Todd Swarthout, Sayaka Gayton-Toyoshima, Nma Mohammed Jiya, Akiko Matsumoto, Leslie Shanks
BACKGROUND: Globally, Médecins Sans Frontières (MSF) treats more than 300,000 severely malnourished children annually. Malnutrition is not only caused by lack of food and poor infant and child feeding practices but also by illnesses. Breaking the vicious cycle of illness and malnutrition by providing ill children with nutritional supplementation is a potentially powerful strategy for preventing malnutrition that has not been adequately investigated. Therefore, MSF investigated whether incidence of malnutrition among ill children <5 y old could be reduced by providing a fortified food product or micronutrients during their 2-wk convalescence period...
February 2016: PLoS Medicine
Bal Kishan Gupta, Anjli Gupta, Hardev Ram Nehra, Heera Ram Balotia, Shyam Lal Meena, Surendra Kumar
INTRODUCTION: Severe malaria remains a major cause of death and morbidity among adults in the Asiatic tropics. This study was planned to evaluate clinical profile and prognostic indicators of severe malaria in adults so as to improve insight into this highly prevalent disease. MATERIALS AND METHODS: This prospective observational study was conducted on 60 confirmed cases of malaria. Cases were divided into two groups: (a) study group: suffering from severe malaria and (b) control group: no severe manifestations...
2015: Infectious Diseases
Ne Myo Aung, Myat Kaung, Tint Tint Kyi, Myat Phone Kyaw, Myo Min, Zaw Win Htet, Nicholas M Anstey, Mar Mar Kyi, Josh Hanson
BACKGROUND: A conservative approach to fluid resuscitation improves survival in children with severe malaria; however, this strategy has not been formally evaluated in adults with the disease. METHODS: Adults hospitalised with malaria at two tertiary referral hospitals in Myanmar received intravenous fluid replacement with isotonic saline, administered at a maintenance rate using a simple weight-based algorithm. Clinical and biochemical indices were followed sequentially...
2015: PloS One
Irene Ule Ngole Sumbele, Orelien S Mtopi Bopda, Helen Kuokuo Kimbi, Teh Rene Ning, Theresa Nkuo-Akenji
BACKGROUND: The contradictory results on the interaction between nutritional status and malaria warrants further investigation in various epidemiological settings, to assert the antagonistic or synergistic relationship. This study examines the prevalence, severity and predictors of malnutrition and its influence on malaria parasitaemia and anaemia severity in children in the Mount Cameroon area. METHODS: A cross-sectional study involving 454 children ≤ 14 years was carried out from February to May 2013 in Muea community...
2015: BMC Public Health
Siyu Xiao, Jinfeng Liu, Shiguang Huang, Fangli Lu
Malaria has been one of the most devastating tropical parasite infectious diseases popular around the world. Severe malaria is characterized by multiple organ dysfunctions, especially liver damage. However, the mechanisms of malarial liver injury remain to be better clarified. In this study, Kunming mice inoculated intraperitoneally (i.p.) with 10(6) Plasmodium berghei ANKA (PbANKA)-infected red blood cells (iRBCs) were investigated at days 5, 10, 15, and 20 post-infection (p.i.) to elucidate the profiles of T-cell immunoglobulin and mucin domain-3 (Tim-3) and its ligand galecin-9 (Gal-9) in the development of liver injury...
February 2016: Parasitology Research
Samuel Rommelaere, Virginie Millet, Pascal Rihet, Scott Atwell, Emmanuèle Helfer, Lionel Chasson, Carole Beaumont, Giovanna Chimini, Maria do Rosário Sambo, Annie Viallat, Carlos Penha-Gonçalves, Franck Galland, Philippe Naquet
Tissue pantetheinase, encoded by the VNN1 gene, regulates response to stress, and previous studies have shown that VNN genes contribute to the susceptibility to malaria. Herein, we evaluated the role of pantetheinase on erythrocyte homeostasis and on the development of malaria in patients and in a new mouse model of pantetheinase insufficiency. Patients with cerebral malaria have significantly reduced levels of serum pantetheinase activity (PA). In mouse, we show that a reduction in serum PA predisposes to severe malaria, including cerebral malaria and severe anemia...
November 2015: American Journal of Pathology
N M Dia, I Diallo, N M Manga, S A Diop, L Fortes-Deguenonvo, N A Lakhe, D Ka, M Seydi, B M Diop, P S Sow
The evaluation of patients by a scale of gravity allows a better categorization of patients admitted in intensive care unit (ICU). Our study had for objective to estimate interest of Ambulatory Simplified Acute Physiologic Score (ASAPS) applied to patients admitted in ICU of infectious diseases department of FANN hospital. It was about a descriptive and analytical retrospective study, made from the data found in patients' files admitted into the USI infectious diseases department of FANN hospital in Dakar, from January 1(st), 2009 till December 31st, 2009...
August 2015: Bulletin de la Société de Pathologie Exotique
Md Anayet Hasan, Md Habibul Hasan Mazumder, Afrin Sultana Chowdhury, Amit Datta, Md Arif Khan
BACKGROUND: Malaria has been a major life threatening mosquito borne disease from long since. Unavailability of any effective vaccine and recent emergence of multi drug resistant strains of malaria pathogen Plasmodium falciparum continues to cause persistent deaths in the tropical and sub-tropical region. As a result, demands for new targets for more effective anti-malarial drugs are escalating. Transketolase is an enzyme of the pentose phosphate pathway; a novel pathway which is involved in energy generation and nucleic acid synthesis...
2015: Source Code for Biology and Medicine
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