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bowel manipulation

Emily G Severance, Kristin L Gressitt, Cassie R Stallings, Emily Katsafanas, Lucy A Schweinfurth, Christina L G Savage, Maria B Adamos, Kevin M Sweeney, Andrea E Origoni, Sunil Khushalani, Faith B Dickerson, Robert H Yolken
The molecules and pathways of the gut-brain axis represent new targets for developing methods to diagnose and treat psychiatric disorders. Manipulation of the gut microbiome with probiotics may be a therapeutic strategy with the potential to relieve gastrointestinal (GI) comorbidities and improve psychiatric symptoms. Candida albicans and Saccharomyces cerevisiae, commensal yeast species, can be imbalanced in the unhealthy human microbiome, and these fungal exposures were previously found elevated in schizophrenia...
November 18, 2016: Brain, Behavior, and Immunity
Christina Feng, Christopher D Graham, Hester F Shieh, Joseph A Brazzo, John Patrick Connors, Lucas Rohrer, Alexander Papadakis, David Zurakowski, Dario O Fauza
BACKGROUND/PURPOSE: Transamniotic stem cell therapy (TRASCET) with amniotic fluid mesenchymal stem cells (afMSCs) has been shown to mitigate bowel damage in a rodent model of gastroschisis. As a prerequisite to clinical translation, we sought to study TRASCET in a larger animal model. METHODS: New Zealand rabbit fetuses (n=64) with surgically created gastroschisis were divided into three groups. One group (untreated) had no further manipulations. Two groups received volume-matched intraamniotic injections of either saline or a suspension of afMSCs...
October 26, 2016: Journal of Pediatric Surgery
S J M Darnaud, L L Southwood, H W Aceto, D Stefanovski, L Tomassone, L Zarucco
It is our clinical impression that age and incision length are more strongly associated with surgical site infection (SSI) following colic surgery than skin closure or wound protection method. Therefore, the objective of this observational clinical cohort study was to identify the risks for SSI in horses undergoing colic surgery. Data collection included pre-, intra-, and postoperative variables. Variables with P < 0.2 following univariable analysis were used in a logistic regression multivariable model...
November 2016: Veterinary Journal
Ceren Orhan, Ozgun Kaya Kara, Serap Kaya, Turkan Akbayrak, Mintaze Kerem Gunel, Gül Baltaci
PURPOSE: The aim of this study was to investigate the effects of connective tissue manipulation (CTM) and Kinesio Taping(®) (KT) on constipation and quality of life in children with cerebral palsy (CP). METHOD: This study was designed as a randomized controlled trial. Forty children diagnosed with chronic constipation based on Rome III criteria were randomly assigned to CTM group [6 females, 7 males; 8 y 6 mo (SD = 3y 4 mo)], KT group [7 female, 7 male; 8y 7 mo (SD =3y 5 mo)] or control group [6 female, 7 male; 8y 3 mo (SD = 3y 6 mo)]...
October 28, 2016: Disability and Rehabilitation
Eoin P Cummins, Daniel Crean
Inflammatory bowel disease (IBD) is a general term to describe inflammatory diseases of the gastrointestinal tract such as Crohn's disease and ulcerative colitis. IBD affects approximately 1 in 200 individuals and exerts a significant health and quality of life burden on patients. Surgical intervention can be curative in ulcerative colitis but there is currently no cure for Crohn's disease. Since this is the case, and the fact that patients are often diagnosed at a young age, IBD exerts a significant financial burden on the health care system, and society as a whole...
September 20, 2016: Microbes and Infection
Anouk Verwoerd, Nienke M Ter Haar, Sytze de Roock, Sebastiaan J Vastert, Debby Bogaert
Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in childhood. The pathogenesis of JIA is thought to be the result of a combination of host genetic and environmental triggers. However, the precise factors that determine one's susceptibility to JIA remain to be unravelled. The microbiome has received increasing attention as a potential contributing factor to the development of a wide array of immune-mediated diseases, including inflammatory bowel disease, type 1 diabetes and rheumatoid arthritis...
September 20, 2016: Pediatric Rheumatology Online Journal
Carl A Nelson, Xiaoli Zhang, Shelby Buettner, Dmitry Oleynikov
Surgical robots in popular clinical use are generally large machines, which limits their practical use to some extent. This study aims to investigate the potential of a small, table-mounted robot for tool guidance in minimally invasive surgery (MIS). In particular, its multipurpose use for guidance of various tools was investigated. A compact robot capable of manipulating MIS tools was designed and built. The robot can move in four degrees of freedom (DOF): three rotational and one translational. These DOF correspond to motion constrained by a trocar...
October 2009: Journal of Robotic Surgery
Esther D Rozeboom, Jeroen G Ruiter, Michel Franken, Matthijs P Schwartz, Stefano Stramigioli, Ivo A M J Broeders
The control of the conventional flexible endoscope is non-ergonomic and non-intuitive. A novel single-handed interface could reduce the experienced workload, without reducing current efficiency or effectiveness of endoscope manipulation. The aim of this study is to evaluate the workload, efficiency and effectiveness of a single-handed controller in colonoscopy, in comparison to a bimanual controller and the conventional angulation wheels. Twenty-one inexperienced students performed colonoscopies on a computer simulator using either the single-handed controller with a joystick interface, a bimanual controller with a joystick interface or the conventional angulation wheels...
December 2014: Journal of Robotic Surgery
Frederik Peeters, Zvi Vaknin, Susie Lau, Claire Deland, Sonya Brin, Walter H Gotlieb
To investigate the development of new technical approaches for improving the implementation of robotics in gynaecologic surgery, we conducted a prospective evaluation of five technical modifications developed during the implementation of a robotics program that included 171 robotic endometrial staging procedures from December 2007 until May 2010. Modification of the use of a Hohl uterine manipulator by applying only the intravaginal component minimizes the theoretical risk of spillage of endometrial cancer cells, without losing the capability of delineating the vaginal fornices...
December 2010: Journal of Robotic Surgery
Lauren K Barron, Christopher P Gayer, Anne Roberts, Jamie M Golden, Bola G Aladegbami, Jun Guo, Christopher R Erwin, Brad W Warner
BACKGROUND: Intestinal failure-associated liver disease causes significant mortality in patients with short bowel syndrome. Steatosis, a major component of intestinal failure-associated liver disease has been shown to persist even after weaning from parenteral nutrition. We sought to determine whether steatosis occurs in our murine model of short bowel syndrome and whether steatosis was affected by manipulation of the intestinal microbiome. METHODS: Male C57BL6 mice underwent 50% small bowel resection and orogastric gavage with vancomycin or vehicle for 10 weeks...
December 2016: Surgery
Daniel Morell-Garcia, Josep M Bauça, Angela García-Suquía, Juan Robles, Bernardino Barceló, Andrea Fernández-Ballina, Juan C Carlos-Vicente
UNLABELLED: The green color in urine may suggest the presence of a severe pathology needing treatment. Many different potential causes of green urine have previously been reported. In our case, after ruling out other potential causes of green urine, it was suggested that the surgical manipulation of the paralytic ileum might have induced the reabsorption of the methylene blue which had been retained in the bowel (bezoar effect), even 96 hours after the nasogastric administration. CONCLUSIONS: The staff should keep in mind this possible effect due to methylene blue to recognize early and avoid unnecessary laboratory tests...
September 2016: Journal of Clinical Anesthesia
Hongxiang Gu, Huiling Zheng, Xiaobing Cui, Ying Huang, Bo Jiang
BACKGROUND AND AIMS: Colon capsule endoscopy has become an alternative method to evaluate the colonic mucosa without pain, sedation, and gas insufflation in recent years. The magnetic-controlled capsule endoscopy (MCCE) system is an innovative ingestible colon capsule. We performed a pilot study to assess its maneuverability and safety among subjects who volunteered to undergo colorectal cancer screening. METHODS: Fifty-seven volunteers underwent both MCCE and colonoscopy procedures...
July 29, 2016: Gastrointestinal Endoscopy
Ayana Okamoto, Keisuke Kohama, Michiko Aoyama-Ishikawa, Hayato Yamashita, Noritomo Fujisaki, Taihei Yamada, Tetsuya Yumoto, Nobuyuki Nosaka, Hiromichi Naito, Kohei Tsukahara, Atsuyoshi Iida, Keiji Sato, Joji Kotani, Atsunori Nakao
BACKGROUND: Postoperative ileus, a transient impairment of bowel motility initiated by intestinal inflammation, is common after an abdominal operation and leads to increased hospital stays and costs. Hydrogen has potent anti-inflammatory and antioxidant properties and potential therapeutic value. Solubilized hydrogen may be a portable and practical means of administering therapeutic hydrogen gas. We hypothesized that intraperitoneal administration of hydrogen-rich saline would ameliorate postoperative ileus...
September 2016: Surgery
Wathsala S Nanayakkara, Paula Ml Skidmore, Leigh O'Brien, Tim J Wilkinson, Richard B Gearry
This review summarizes the published clinical studies concerning the management of irritable bowel syndrome (IBS) using restriction of Fermentable Oligosaccharide, Disaccharide, Monosaccharide, and Polyols in the diet (low FODMAP diet). In recent years, the data supporting low FODMAP diet for the management of IBS symptoms have emerged, including several randomized controlled trials, case-control studies, and other observational studies. Unlike most dietary manipulations tried in the past to alleviate gastrointestinal symptoms of IBS, all studies on low FODMAP diet have consistently shown symptomatic benefits in the majority of patients with IBS...
2016: Clinical and Experimental Gastroenterology
Andrea Bilková, František Bilka, Hana Kinová Sepová
UNLABELLED: The number of preclinical and clinical studies showing efficacy of probiotics in the treatment and prophylaxis of certain diseases, e.g. diarrhoea of various origin, irritable bowel syndrome, inflammatory bowel disease, allergies, hypercholesterolemia, bacterial vaginosis, and colorectal cancer, is increasing. These health benefits are often species and strain specific. This article provides an overview of available knowledge about the supposed mechanisms of probiotic microorganisms action focusing in particular on the interaction between probiotic and host cells...
2016: Ceská a Slovenská Farmacie
Raffaele Tinelli, Ettore Cicinelli, Andrea Tinelli, Stefano Bettocchi, Stefano Angioni, Pietro Litta
OBJECTIVE: The aim of this study was to retrospectively compare in a series of 110 patients with early-stage endometrial cancer recurrence rate and surgical outcomes after total laparoscopic (LPS) hysterectomy with lymphadenectomy performed with or without uterine manipulator. STUDY DESIGN: 110 patients with clinical stage I endometrial cancer were enrolled in a retrospective study and underwent surgical staging comprised of LPS hysterectomy, bilateral salpingo-oophorectomy, and in all cases we performed systematic bilateral pelvic lymphadenectomy with uterine manipulator (Group 1, 55 patients) or without (Group 2, 55 patients)...
June 2016: Surgical Oncology
Jan S Suchodolski, Albert E Jergens
The importance of the microbiome in health and disease has galvanized interest in using manipulations of the gastrointestinal ecosystem to prevent and/or combat gut bacterial infections and to restore mucosal homeostasis in patients with generalized microbial imbalances (i.e., dysbiosis), including the human inflammatory bowel diseases, Crohn's disease, and ulcerative colitis. Probiotics, prebiotics, or their combination use (i.e., synbiotics) are one mechanism for modifying the microbiota and exerting direct and indirect effects on the host immune responses and metabolomics profiles...
April 2016: Microbiology Spectrum
Verena Grimm, Christian U Riedel
A number of diseases are associated with alterations in the composition of the microbiota of various niches of the human body. Although, in most cases, it is unclear if these alterations are the cause or the consequence of disease, they provide a rationale for therapeutic or prophylactic manipulation of a dysbiotic microbiota. Approaches to manipulate the microbiome include administration of either live bacteria, which are underrepresented in the diseased individual, substances that aim at increasing the populations of these bacteria, or a combination of the two...
2016: Advances in Experimental Medicine and Biology
Marco Annoni, Franklin G Miller
In this article we explore the ethics of manipulating verbal information for the sake of influencing health outcomes through placebo and nocebo responses. Recent scientific research on placebo and nocebo effects has drawn attention to the ways in which communication by health professionals may modulate the symptoms of patients across an array of highly prevalent conditions such as pain, depression, anxiety, insomnia, irritable bowel syndrome, migraine, and Parkinson's disease. The positive and negative effects of clinicians' communication on patient outcomes pose important ethical issues, which we describe in this article under the label of "the ethics of therapeutic communication" (TC)...
March 2016: Kennedy Institute of Ethics Journal
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