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https://www.readbyqxmd.com/read/29668044/impairments-in-hemodynamic-responses-to-orthostasis-associated-with-frailty-results-from-the-irish-longitudinal-study-on-ageing-tilda
#1
Matthew Dl O'Connell, George M Savva, Ciarán Finucane, Roman Romero-Ortuno, Chie Wei Fan, Rose Anne Kenny
OBJECTIVES: To characterize the relationships between orthostatic blood pressure (BP) and heart rate recovery and frailty in an older population. DESIGN: Cross-sectional study. SETTING: Two health centers in the Republic of Ireland. PARTICIPANTS: The Irish Longitudinal Study on Ageing participants aged 50 and older (N=4,334). MEASUREMENTS: Continuous noninvasive BP responses during active standing were captured using digital photoplethysmography...
April 18, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29668017/phylogeographic-analyses-of-the-pampas-cat-leopardus-colocola-carnivora-felidae-reveal-a-complex-demographic-history
#2
Anelisie da Silva Santos, Tatiane Campos Trigo, Tadeu Gomes de Oliveira, Leandro Silveira, Eduardo Eizirik
The pampas cat is a small felid that occurs in open habitats throughout much of South America. Previous studies have revealed intriguing patterns of morphological differentiation and genetic structure among its populations, as well as molecular evidence for hybridization with the closely related L. tigrinus. Here we report phylogeographic analyses encompassing most of its distribution (focusing particularly on Brazilian specimens, which had been poorly sampled in previous studies), using a novel dataset comprising 2,143 bp of the mitogenome, along with previously reported mtDNA sequences...
2018: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/29667932/fused-data-transrectal-eit-for-prostate-cancer-imaging
#3
Ethan K Murphy, Xiaotian Wu, Ryan J Halter
OBJECTIVE: Prostate cancer is a significant problem affecting 1 in 7 men. Unfortunately, the diagnostic gold-standard of ultrasound-guided biopsy misses 10-30% of all cancers. The objective of this study was to develop an Electrical Impedance Tomography (EIT) approach that has the potential to image the entire prostate using multiple impedance measurements recorded between electrodes integrated onto an end-fired transrectal ultrasound (TRUS) device and a biopsy probe (BP). APPROACH: Simulations and sensitivity analyses were used to investigate the best combination of electrodes, and measured tank experiments were used to evaluate a fused-data transrectal EIT (fd-TREIT) and BP approach...
April 18, 2018: Physiological Measurement
https://www.readbyqxmd.com/read/29667182/breathing-regulation-and-blood-gas-homeostasis-after-near-complete-lesions-of-the-retrotrapezoid-nucleus-in-adult-rats
#4
George M P R Souza, Roy Kanbar, Daniel S Stornetta, Stephen B G Abbott, Ruth L Stornetta, Patrice G Guyenet
The retrotrapezoid nucleus (RTN) is one of several CNS nuclei that contribute, in various capacities (e.g. CO2 detection, neuronal modulation) to the central respiratory chemoreflex (CRC). Here we test how important the RTN is to PCO2 homeostasis and breathing during sleep or wake. RTN Nmb positive neurons were killed with targeted microinjections of substance-P-saporin conjugate in adult rats. Under normoxia, rats with large RTN lesions (92 ± 4 % cell loss) had normal blood pressure (BP) and arterial pH but were hypoxic (-8 mmHg PaO2 ) and hypercapnic (+10 mmHg PaCO2 )...
April 18, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29666886/whole-genome-sequence-and-genome-annotation-of-xanthomonas-citri-pv-mangiferaeindicae-causal-agent-of-bacterial-black-spot-on-mangifera-indica
#5
Feng Liu, Xiong-Chang Ou, Ru-Lin Zhan
A newly isolated strain XC01 was identified as Xanthomonas citri pv. mangiferaeindicae, isolated from an infected mango fruit in Guangxi, China. The complete genome sequence of XC01 was carried out using the PacBio RSII platform. The genome contains a circular chromosome with 3,865,165 bp, 3442 protein-coding genes, 53 tRNAs, and 2 rRNA operons. Phylogenetic analysis revealed that this pathogen is very close to the soybeans bacterial pustule pathogen X. citri pv. glycines CFBP 2526, with a completely different host range...
April 17, 2018: Archives of Microbiology
https://www.readbyqxmd.com/read/29666761/transcriptome-profiling-of-anthocyanin-related-genes-reveals-effects-of-light-intensity-on-anthocyanin-biosynthesis-in-red-leaf-lettuce
#6
Yanzhao Zhang, Shuzhen Xu, Yanwei Cheng, Zhengfeng Peng, Jianming Han
Red leaf lettuce ( Lactuca sativa L.) is popular due to its high anthocyanin content, but poor leaf coloring often occurs under low light intensity. In order to reveal the mechanisms of anthocyanins affected by light intensity, we compared the transcriptome of L. sativa L. var. capitata under light intensities of 40 and 100 μmol m-2 s-1 . A total of 62,111 unigenes were de novo assembled with an N50 of 1,681 bp, and 48,435 unigenes were functionally annotated in public databases. A total of 3,899 differentially expressed genes (DEGs) were detected, of which 1,377 unigenes were up-regulated and 2,552 unigenes were down-regulated in the high light samples...
2018: PeerJ
https://www.readbyqxmd.com/read/29666671/the-comparative-experimental-study-of-multilabel-classification-for-diagnosis-assistant-based-on-chinese-obstetric-emrs
#7
Kunli Zhang, Hongchao Ma, Yueshu Zhao, Hongying Zan, Lei Zhuang
Obstetric electronic medical records (EMRs) contain massive amounts of medical data and health information. The information extraction and diagnosis assistants of obstetric EMRs are of great significance in improving the fertility level of the population. The admitting diagnosis in the first course record of the EMR is reasoned from various sources, such as chief complaints, auxiliary examinations, and physical examinations. This paper treats the diagnosis assistant as a multilabel classification task based on the analyses of obstetric EMRs...
2018: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29666337/mitochondrial-signatures-revealed-panmixia-in-lutjanus-argentimaculatus-forssk%C3%A3-l-1775
#8
A Gopalakrishnan, N Vineesh, Shihab Ismail, Muktha Menon, K V Akhilesh, N S Jeena, M P Paulton, P Vijayagopal
Mangrove red snapper, Lutjanus argentimaculatus is a commercially important fish. The genetic stock structure of L. argentimaculatus from Indian waters was identified using mitochondrial ATPase 6 and ATPase 8, and cytochrome b (Cytb) genes. A 842 bp region of ATPase 6/8 genes and 1105 bp region of Cytb gene were amplified in 120 samples from six different locations along the Indian coast and obtained 58 and 66 haplotypes, respectively. The high haplotype and low nucleotide diversity values along with mismatch distribution, Tajima's D and Fu's Fs analysis suggested a genetic bottleneck events or founder effect, with subsequent population expansion in L...
March 2018: Journal of Genetics
https://www.readbyqxmd.com/read/29666332/expression-profiles-of-amh-and-foxl2-in-schizothorax-kozlovi-and-their-response-to-temperature-during-the-early-developmental-stage
#9
Yongfeng He, Xuge Wang, Xingbing Wu, Yongjiu Zhu, Deguo Yang
To elucidate the role of amh and foxl2 in sex differentiation of the teleost fish Schizothorax kozlovi, the full-length cDNAs were cloned from the mature testis and ovary by rapid amplification of cDNA ends (RACE), and their relative mRNA expression levels were determined by quantitative real-time polymerase chain reaction among tissues and temperature groups. The complete amh and foxl2 cDNAs of S. kozlovi were 2060 bp and 1750 bp, which encoded 568 and 306 amino acids, respectively. The amh were expressed only in gonads, while foxl2 was expressed in the gills, brain and gonads, both exhibiting relatively high tissue specificity...
March 2018: Journal of Genetics
https://www.readbyqxmd.com/read/29666328/characterization-of-specific-dna-markers-at-vrn-h1-and-vrn-h2-loci-for-growth-habit-of-barley-genotypes
#10
Zahra Sadat Taheripourfard, Ali Izadi-Darbandi, Habibollah Ghazvini, Mohsen Ebrahimi, Seyed Mohammad Mahdi Mortazavian
Requirement of vernalization is an important factor which plays a crucial role in cereals to transit from vegetative to reproductive phase. There are three types of growth habit in barley: winter, spring and facultative types; in which spring type does not require vernalization but winter and facultative genotypes require full and partial vernalization, respectively. Combination of two loci, Vrn-h1 and Vrn-h2, regulates vernalization in barley genotypes. Specific DNA markers have been identified for growth habit regulator genes in barley...
March 2018: Journal of Genetics
https://www.readbyqxmd.com/read/29666320/y-chromosome-polymorphisms-of-the-domestic-bactrian-camel-in-china
#11
Huiling Chen, Zhanjun Ren, Jiping Zhao, Chengdong Zhang, Xuejiao Yang
Single-nucleotide polymorphisms (SNPs), microsatellites and copy number variation (CNV) were studied on the Y chromosome to understand the paternal origin and phylogenetic relationships for resource protection, rational development and utilization of the domestic Bactrian camel in China. Our sample set consisted of 94 Chinese domestic Bactrian camels from four regions (Inner Mongolia, Gansu, Qinghai and Xinjiang), we screened 29 Y-chromosome-specific loci for SNPs, analysed 40 bovine-derived microsatellite loci and measured CNVs of HSFY and SRY through Sanger sequencing, automated fluorescence-based microsatellite analysis and quantitative real-time PCR, respectively...
March 2018: Journal of Genetics
https://www.readbyqxmd.com/read/29666291/determining-the-specificity-of-cascade-binding-interference-and-primed-adaptation-in-vivo-in-the-escherichia-coli-type-i-e-crispr-cas-system
#12
Lauren A Cooper, Anne M Stringer, Joseph T Wade
In clustered regularly interspaced short palindromic repeat (CRISPR)-Cas (CRISPR-associated) immunity systems, short CRISPR RNAs (crRNAs) are bound by Cas proteins, and these complexes target invading nucleic acid molecules for degradation in a process known as interference. In type I CRISPR-Cas systems, the Cas protein complex that binds DNA is known as Cascade. Association of Cascade with target DNA can also lead to acquisition of new immunity elements in a process known as primed adaptation. Here, we assess the specificity determinants for Cascade-DNA interaction, interference, and primed adaptation in vivo , for the type I-E system of Escherichia coli Remarkably, as few as 5 bp of crRNA-DNA are sufficient for association of Cascade with a DNA target...
April 17, 2018: MBio
https://www.readbyqxmd.com/read/29666156/circulating-bacterial-fragments-as-cardiovascular-risk-factors-in-ckd
#13
Cheuk-Chun Szeto, Christopher William McIntyre, Philip Kam-Tao Li
Cardiovascular disease (CVD) is a major cause of mortality and morbidity in patients with CKD. In the past decade, intestinal dysbiosis and altered gut epithelial barrier function are increasingly recognized in CKD. Uremic patients have slow intestinal transit time, impaired protein assimilation, and decreased consumption of dietary fiber. The use of multiple medications also may contribute to the proliferation of dysbiotic bacteria, which affect the barrier function of intestinal epithelium. In addition, fluid overload and uremic toxins per se directly reduce the gut barrier function...
April 17, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29665941/-research-on-ralation-of-long-non-coding-rna-with-diffuse-large-b-cell-lymphomas-review
#14
Yan-Yuan Wu, Yi-Ran Xing, Duo-Nan Yu
Diffuse large B-cell lymphoma (DLBCL) accounts for approximately 30% of the non-Hodgkin's lymphoma patients. The underlying molecular mechanism of its pathogenesis is not well defined and the survival rate of DLBCL patients is very low. Moreover, the annual incidence and mortality of DLBCL is still rising. Accordingly, identification and characterization of new molecular pathways of DLBCL will lead to the development of novel diagnostic markers and molecular therapeutic targets. Long non-coding RNAs (LncRNA) are non-coding RNAs with a length greater than 200 bp in eukaryotic cells, which can regulate the expression of their target genes at the transcriptional and post transcriptional levels...
April 2018: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/29665905/-relationship-between-dnmt1-and-methylation-of-shp-1-promoter-2-in-k562-cells
#15
Xue-Dong Liu, Xiao Liu, Xiu-Fen Guo, Jian-Min Luo, Ying-Hua Li
OBJECTIVE: To investigate the relationship of DNA methyltransferase 1 ( DNMT1 ) with hematopoietic cell phosphatase (SHP-1) gene expression and promoter 2 methylation status in cell line K562. METHODS: The promoter sequence of SHP-1 gene promoter 2 in NCBI database was analyzed, the K562 cells were transfected with the lentiviral plasmids-the specified retroviral vector psiHIV-mU6-shDNMT1 and psiHIV-mU6-mcherryFP-control. The methylation status of SHP-1 gene promoter 2 in K562 cells was detected by methylation-specific polymerase chain reaction (MSP) and bisulfite-modified sequencing (BSP)...
April 2018: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/29665863/effect-of-combined-treatment-with-bisphosphonate-and-vitamin-d-on-atherosclerosis-in-patients-with-systemic-lupus-erythematosus-a-propensity-score-based-analysis
#16
Kazumasa Ohmura, Masaru Kato, Toshiyuki Watanabe, Kenji Oku, Toshiyuki Bohgaki, Tetsuya Horita, Shinsuke Yasuda, Yoichi M Ito, Norihiro Sato, Tatsuya Atsumi
BACKGROUND: Premature atherosclerosis is one of the major complications of systemic lupus erythematosus (SLE). Recently, the biological linkage between atherosclerosis and osteoporosis has garnered much attention. The aim of this study is to explore correlation between the development of atherosclerosis and anti-osteoporotic treatment. METHODS: Consecutive patients with SLE (n = 117) who underwent carotid ultrasonography were retrospectively analyzed using propensity scoring...
April 17, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29665518/early-intervention-for-adolescents-at-risk-for-bipolar-disorder-a-pilot-randomized-trial-of-interpersonal-and-social-rhythm-therapy-ipsrt
#17
Tina R Goldstein, John Merranko, Megan Krantz, Matthew Garcia, Peter Franzen, Jessica Levenson, David Axelson, Boris Birmaher, Ellen Frank
OBJECTIVE: To conduct a pilot randomized trial of Interpersonal and Social Rhythm Therapy plus Data-Informed Referral (IPSRT + DIR) versus DIR-alone for adolescents at-risk for bipolar disorder (BP). METHOD: Eligible participants included youth (12-18) with a BP parent; youth with BP were excluded. Participants (n = 42) were randomized to receive IPSRT + DIR to treat any psychiatric disorders present at baseline, or DIR-alone. A blind evaluator assessed outcomes at baseline, 3- and 6-months...
April 7, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29665418/a-continuous-genome-assembly-of-the-corkwing-wrasse-symphodus-melops
#18
Morten Mattingsdal, Sissel Jentoft, Ole K Tørresen, Halvor Knutsen, Michael M Hansen, Joana I Robalo, Zuzanna Zagrodzka, Carl André, Enrique Blanco Gonzalez
The wrasses (Labridae) are one of the most successful and species-rich families of the Perciformes order of teleost fish. Its members display great morphological diversity, and occupy distinct trophic levels in coastal waters and coral reefs. The cleaning behaviour displayed by some wrasses, such as corkwing wrasse (Symphodus melops), is of particular interest for the salmon aquaculture industry to combat and control sea lice infestation as an alternative to chemicals and pharmaceuticals. There are still few genome assemblies available within this fish family for comparative and functional studies, despite the rapid increase in genome resources generated during the past years...
April 14, 2018: Genomics
https://www.readbyqxmd.com/read/29665321/a-novel-ano5-splicing-variant-in-a-lgmd2l-patient-leads-to-production-of-a-truncated-aggregation-prone-ano5-peptide
#19
Jing Xu, Li Xu, Yeh S Lau, Yandi Gao, Steven A Moore, Renzhi Han
Mutations in ANO5 cause several human diseases including gnathodiaphyseal dysplasia 1 (GDD1), limb-girdle muscular dystrophy 2L (LGMD2L), and Miyoshi myopathy 3 (MMD3). Previous work showed that complete genetic disruption of Ano5 in mice did not recapitulate human muscular dystrophy, while residual expression of mutant Ano5 in a gene trapped mouse developed muscular dystrophy with defective membrane repair. This suggests that truncated Ano5 expression may be pathogenic. Here, we screened a panel of commercial anti-Ano5 antibodies using a recombinant adenovirus expressing human Ano5 with FLAG and YFP at the N- and C-terminus, respectively...
April 2018: Journal of Pathology. Clinical Research
https://www.readbyqxmd.com/read/29665297/esmolol-acutely-alters-oxygen-supply-demand-balance-in-exercising-muscles-of-healthy-humans
#20
David N Proctor, J Carter Luck, Stephan R Maman, Urs A Leuenberger, Matthew D Muller
Beta-adrenoreceptor antagonists (β blockers) reduce systemic O2 delivery and blood pressure (BP) during exercise, but the subsequent effects on O2 extraction within the active limb muscles are unknown. In this study, we examined the effects of the fast-acting, β1 selective blocker esmolol on systemic hemodynamics and leg muscle O2 saturation (near infrared spectroscopy, NIRS) during submaximal leg ergometry. Our main hypothesis was that esmolol would augment exercise-induced reductions in leg muscle O2 saturation...
April 2018: Physiological Reports
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