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https://www.readbyqxmd.com/read/29050317/microrna-542-3p-inhibits-oral-squamous-cell-carcinoma-progression-by-inhibiting-ilk-tgf-%C3%AE-1-smad2-3-signaling
#1
Bin Qiao, Jing-Hua Cai, Alfred King-Yin Lam, Bao-Xia He
In this study, we investigated the effects of microRNA-542-3p (miR-542-3p) on ILK/TGF-β1/Smad2/3 signaling and oral squamous cell carcinoma (OSCC) progression. Levels of miR-542-3p were lower in OSCC tissues (n=108) than adjacent normal tissues, whereas levels of ILK, TGF-β1 and Smad2/3 were higher. Patients with undifferentiated tumors, advanced TNM stage and lymph node metastasis showed low miR-542-3p levels. This was accompanied by high ILK expression and poor survival. Dual luciferase reporter assays of SCC-9 cells showed that miR-542-3p inhibited ILK gene expression by binding to its 3'UTR at 233-240 bp...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29049965/development-of-a-molecular-method-for-testing-the-effectiveness-of-uv-systems-on-site
#2
Limor Nizri, Dalit Vaizel-Ohayon, Hila Ben-Amram, Yehonatan Sharaby, Malka Halpern, Hadas Mamane
We established a molecular method for quantifying ultraviolet (UV) disinfection efficacy using total bacterial DNA in a water sample. To evaluate UV damage to the DNA, we developed the "DNA damage" factor, which is a novel cultivation-independent approach that reveals UV-exposure efficiency by applying a simple PCR amplification method. The study's goal was to prove the feasibility of this method for demonstrating the efficiency of UV systems in the field using flow-through UV reactors. In laboratory-based experiments using seeded bacteria, the DNA damage tests demonstrated a good correlation between PCR products and UV dose...
October 10, 2017: Water Research
https://www.readbyqxmd.com/read/29049415/effect-of-diacerein-on-renal-function-and-inflammatory-cytokines-in-participants-with-type-2-diabetes-mellitus-and-chronic-kidney-disease-a-randomized-controlled-trial
#3
Fabiana Piovesan, Glaucia S Tres, Leila B Moreira, Michael E Andrades, Hugo K Lisboa, Sandra C Fuchs
Diacerein seems to improve metabolic control and reduce inflammatory marker levels in individuals with type 2 diabetes mellitus (Type 2 DM), but for participants with chronic kidney disease (CKD) its effect is unknown. This study aimed to evaluate the effect of diacerein vs. placebo on urinary albumin/creatinine ratio (ACR), glomerular filtration rate (GFR), and inflammatory cytokines in type 2 DM participants with CKD. Blood pressure (BP) and metabolic control were secondary outcomes. This randomized, placebo-controlled, parallel trial of adjuvant treatment of type 2 DM with diacerein enrolled seventy-two participants with CKD, aged 30-80 years, with glycated hemoglobin levels from 53-97 mmol/mol (7...
2017: PloS One
https://www.readbyqxmd.com/read/29049367/the-inner-mantle-of-the-giant-clam-tridacna-squamosa-expresses-a-basolateral-na-k-atpase-%C3%AE-subunit-which-displays-light-dependent-gene-and-protein-expression-along-the-shell-facing-epithelium
#4
Mel V Boo, Kum C Hiong, Celine Y L Choo, Anh H Cao-Pham, Wai P Wong, Shit F Chew, Yuen K Ip
Na+/K+-ATPase (NKA) is essential for maintaining the Na+ and K+ gradients, and supporting the secondary active transport of certain ions/molecules, across the plasma membrane of animal cells. This study aimed to clone the NKA α-subunit (NKAα) from the inner mantle adjacent to the extrapallial fluid of Tridacna squamosa, to determine its subcellular localization, and to examine the effects of light exposure on its transcript level and protein abundance. The cDNA coding sequence of NKAα from T. squamosa comprised 3105 bp, encoding 1034 amino acids with an estimated molecular mass of 114 kDa...
2017: PloS One
https://www.readbyqxmd.com/read/29049308/the-relationship-between-intradialytic-hypotension-and-vascular-calcification-in-hemodialysis-patients
#5
AJin Cho, Young-Ki Lee, Jieun Oh, Jong-Woo Yoon, Dong Ho Shin, Hee Jung Jeon, Myung-Jin Choi, Jung-Woo Noh
BACKGROUND: Vascular calcification is associated with structural and functional abnormality of the heart and blood vessels. We investigated the relationship between intradialytic hypotension (IDH) and vascular calcification in hemodialysis (HD) patients, and their impacts on cardiovascular events (CVEs). METHOD: We enrolled 191 maintenance HD patients who underwent plain abdomen radiography for abdominal aortic calcification score (AACS). A nadir systolic blood pressure (BP) < 90 mm Hg or the requirement of bolus fluid administration was required to quantify the hypotension diagnosis...
2017: PloS One
https://www.readbyqxmd.com/read/29049241/evaluation-of-the-reduction-in-central-and-peripheral-arterial-blood-pressure-following-an-oral-glucose-load
#6
Shunsuke Murai, Hiroyuki Takase, Tomonori Sugiura, Sumiyo Yamashita, Nobuyuki Ohte, Yasuaki Dohi
The clinical significance of measuring central arterial blood pressure has been recently discussed. Although the postprandial reduction in blood pressure is well known, postprandial changes in central blood pressure have not been intensively studied. The present study investigated differences in the reduction of central and peripheral arterial blood pressure after administration of an oral glucose load.An oral glucose tolerance test (75 g) was performed in 360 participants in our physical checkup program...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29049227/association-of-central-blood-pressure-and-cardiovascular-diseases-in-diabetic-patients-with-hypertension
#7
Lei Yang, Bo Qin, Xiaojuan Zhang, Yanrong Chen, Jian Hou
To evaluate association of central blood pressure (BP) and cardiovascular disease (CVD) in diabetic patients with hypertension.This was a cross-section study and 360 participants were enrolled. Baseline characteristics were collected and indices of central BP including central systolic/diastolic BP (SBP/DBP), augmentation index adjusted for 75 beats per minute of heart rate (AIx@75) were measured. Participants were separated into with and without CVD groups and between-group differences were assessed. Linear regression analysis was used to evaluate potential risk factors for increased AIx@75...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29049222/lower-blood-pressure-and-smaller-pulse-pressure-in-sleeping-pill-users-a-large-scale-cross-sectional-analysis
#8
Nobuo Sasaki, Saeko Fujiwara, Ryoji Ozono, Hidehisa Yamashita, Yasuki Kihara
This study aimed to investigate the association between sleeping pill use and hypertension or blood pressure (BP) via a cross-sectional analysis.A total of 11,225 subjects (5875 men and 5350 women) underwent health examinations. We compared the proportion of sleeping pill users among hypertension (n = 5099) and normotensive (n = 6126) participants. We analyzed participants with no intake of antihypertensive medication (n = 7788), comparing the proportions with high systolic BP (SBP) ≥140, high diastolic BP (DBP) ≥90, and high pulse pressure (PP) ≥50 mm Hg across 3 subgroups...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29049203/standing-beat-to-beat-blood-pressure-variability-is-reduced-among-fallers-in-the-malaysian-elders-longitudinal-study
#9
Choon-Hian Goh, Siew-Cheok Ng, Shahrul Bahyah Kamaruzzaman, Ai-Vyrn Chin, Maw Pin Tan
The aim of this study was to determine the relationship between falls and beat-to-beat blood pressure (BP) variability.Continuous noninvasive BP measurement is as accurate as invasive techniques. We evaluated beat-to-beat supine and standing BP variability (BPV) using time and frequency domain analysis from noninvasive continuous BP recordings.A total of 1218 older adults were selected. Continuous BP recordings obtained were analyzed to determine standard deviation (SD) and root mean square of real variability (RMSRV) for time domain BPV and fast-Fourier transform low frequency (LF), high frequency (HF), total power spectral density (PSD), and LF:HF ratio for frequency domain BPV...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29049094/validation-of-the-avita-bpm64-upper-arm-blood-pressure-monitor-for-home-blood-pressure-monitoring-according-to-the-european-society-of-hypertension-international-protocol-revision-2010
#10
Yuan-Yuan Kang, Qi Chen, Chang-Yuan Liu, Yan Li, Ji-Guang Wang
OBJECTIVE: The aim of this study was to evaluate the accuracy of the automated oscillometric upper arm blood pressure (BP) monitor AVITA BPM64 for home BP monitoring according to the International Protocol of the European Society of Hypertension revision 2010. METHODS: Systolic and diastolic BPs were measured sequentially in 33 adult Chinese (14 women, mean age 47.0 years) using a mercury sphygmomanometer (two observers) and the AVITA BPM64 device (one supervisor)...
October 18, 2017: Blood Pressure Monitoring
https://www.readbyqxmd.com/read/29049087/raising-mean-arterial-pressure-alone-restores-20-of-intraoperative-neuromonitoring-losses
#11
Joshua Yang, David L Skaggs, Priscella Chan, Suken A Shah, Michael G Vitale, Geraldine Neiss, Nicholas Feinberg, Lindsay M Andras
STUDY DESIGN: Multicenter prospective. OBJECTIVE: To assess the effect of intraoperative interventions in restoring intraoperative neuromonitoring (IONM) signals in pediatric spine surgery. SUMMARY OF BACKGROUND DATA: No prior studies have prospectively examined the rate of return of IONM signals by increasing blood pressure (BP) alone. METHODS: Patients undergoing posterior spinal deformity surgery were enrolled at their preoperative appointment...
October 18, 2017: Spine
https://www.readbyqxmd.com/read/29049001/effects-of-melatonin-on-mechanisms-involved-in-hypertension-using-human-umbilical-vein-endothelial-cells
#12
Guangfang Shao, Suping Zhang, Jihua Nie, Jianxiang Li, Jian Tong
Changes in diurnal rhythmicity in blood pressure (BP) are associated with hypertension and consequent cardiovascular damage. The involvement of diurnal rhythmicity as a pathogenic factor in hypertension is not fully understood. Since the hormone melatonin (MLT) regulates circadian rhythm, it was also of interest to determine whether this hormone played a role in hypertension-related alterations in circadian rhythm. Thus the aim of this study was to examine the mechanisms underlying MLT-mediated antihypertension...
October 19, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/29048932/cardio-ankle-vascular-index-value-in-dyslipidemia-patients-affected-by-cardiovascular-risk-factors
#13
XiaoXiao Zhao, Liujin Bo, Hongwei Zhao, Lihong Li, Yingyan Zhou, Hongyu Wang
BACKGROUND: Increased arterial stiffness is an independent cardiovascular risk factor in smokers or patients with diabetes mellitus and hypertension. Cardio-ankle vascular index (CAVI) is an index of arterial stiffness and atherosclerosis. One of the most important risk factors of the causes of atherosclerosis is dyslipidemia(DLP). However, there was a little research about which influence factors such as: hypertension, diabetes mellitus, and smoking could contribute to the atherosclerosis in the subjects withDLP...
October 19, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29048578/genome-assembly-and-transcriptome-resource-for-river-buffalo-bubalus-bubalis-2n-50
#14
John L Williams, Daniela Iamartino, Kim D Pruitt, Tad Sonstegard, Timothy P L Smith, Wai Yee Low, Tommaso Biagini, Lorenzo Bomba, Stefano Capomaccio, Bianca Castiglioni, Angelo Coletta, Federica Corrado, Fabrizio Ferré, Leopoldo Iannuzzi, Cynthia Lawley, Nicolò Macciotta, Matthew McClure, Giordano Mancini, Donato Matassino, Raffaele Mazza, Marco Milanesi, Bianca Moioli, Nicola Morandi, Luigi Ramunno, Vincenzo Peretti, Fabio Pilla, Paola Ramelli, Steven Schroeder, Francesco Strozzi, Francoise Thibaud-Nissen, Luigi Zicarelli, Paolo Ajmone-Marsan, Alessio Valentini, Giovanni Chillemi, Aleksey Zimin
Water buffalo is a globally important species for agriculture and local economies. A de novo assembled, well annotated, reference sequence for the water buffalo is an important prerequisite for studying the biology of this species, and necessary to manage genetic diversity and to use modern breeding and genomic selection techniques. However, no such genome assembly has been previously reported. There are two species of domestic water buffalo, the river (2n = 50) and the swamp (2n = 48) buffalo. Here we describe a draft quality reference sequence for the river buffalo created from Illumina GA and Roche 454 short read sequences using the MaSuRCA assembler...
September 1, 2017: GigaScience
https://www.readbyqxmd.com/read/29048540/long-read-sequencing-of-the-coffee-bean-transcriptome-reveals-the-diversity-of-full-length-transcripts
#15
Bing Cheng, Agnelo Furtado, Robert J Henry
Background: Polyploidization contributes to the complexity of gene expression resulting in numerous related but different transcripts. This study explored the transcriptome diversity and complexity of tetraploid Arabica coffee ( Coffea arabica ) bean. Long-read sequencing (LRS) by Pacbio Isoform sequencing (Iso-seq) was used to obtain full-length transcripts without the difficulty and uncertainty of assembly required for reads from short read technologies. The tetraploid transcriptome was annotated and compared with data from the sub-genome progenitors...
August 30, 2017: GigaScience
https://www.readbyqxmd.com/read/29048527/the-evolution-of-dark-matter-in-the-mitogenome-of-seed-beetles
#16
Ahmed Sayadi, Elina Immonen, Christian Tellgren-Roth, Göran Arnqvist
Animal mitogenomes are generally thought of as being economic and optimized for rapid replication and transcription. We use long-read sequencing technology to assemble the remarkable mitogenomes of four species of seed beetles. These are the largest circular mitogenomes ever assembled in insects, ranging from 24,496 to 26,613 bp in total length, and are exceptional in that some 40% consists of non-coding DNA. The size expansion is due to two very long intergenic spacers (LIGSs), rich in tandem repeats. The two LIGSs are present in all species but vary greatly in length (114-10,408 bp), show very low sequence similarity, divergent tandem repeat motifs, a very high AT content and concerted length evolution...
October 1, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/29048064/triple-brillouin-frequency-spacing-multiwavelength-fiber-laser-with-double-brillouin-cavities-and-its-application-in-microwave-signal-generation
#17
Zhen Wang, Tianshu Wang, Qingsong Jia, Wanzhuo Ma, Qingchao Su, Peng Zhang
We propose and experimentally investigate a multiwavelength Brillouin fiber laser (MBFL) with triple frequency spacing by employing a modular structure. In this scheme, we obtain nine channels optimized with frequency spacing of 0.259 nm. The single, double, and triple Brillouin frequency spacing for the MBFL can be easily realized by utilizing this modular structure. The impact of Brillouin pump (BP) power, BP wavelength, and erbium-ytterbium-doped fiber amplifier (EYDFA) output power on the performance of the MBFL is investigated, respectively...
September 10, 2017: Applied Optics
https://www.readbyqxmd.com/read/29048028/re-examining-the-effect-of-particle-phase-functions-on-the-remote-sensing-reflectance
#18
Yuanheng Xiong, Xiaodong Zhang, Shuangyan He, Deric J Gray
Even though it is well known that both the magnitude and detailed angular shape of scattering (phase function, PF), particularly in the backward angles, affect the color of the ocean, the current remote-sensing reflectance (Rrs) models typically account for the effect of its magnitude only through the backscattering coefficient (bb). Using 116 volume scattering function (VSF) measurements previously collected in three coastal waters around the U.S. and in the water of the North Atlantic Ocean, we re-examined the effect of particle PF on Rrs in four scenarios...
August 20, 2017: Applied Optics
https://www.readbyqxmd.com/read/29047931/black-phosphorus-flakes-covered-microfiber-for-q-switched-ytterbium-doped-fiber-laser
#19
Ke-Xun Huang, Bao-Le Lu, Diao Li, Xin-Yuan Qi, Hao-Wei Chen, Na Wang, Zeng-Run Wen, Jin-Tao Bai
We demonstrate a passively Q-switched ytterbium-doped fiber laser based on black phosphorus (BP) flakes covered microfiber. The BP saturable absorber is fabricated by sandwiching a microfiber between two pieces of polydimethylsiloxane supported BP flakes film, which is prepared by the mechanical exfoliation method. In this case the BP flakes can be well protected from the action of air and moisture. By incorporating BP flakes covered microfiber into a ytterbium-doped ring fiber laser, stable and reliable Q-switched operation at 1064 nm can be realized via interaction between few-layers BP flakes and the evanescent field of the laser...
August 10, 2017: Applied Optics
https://www.readbyqxmd.com/read/29047361/cross-cultural-validation-of-simplified-chinese-version-of-spine-functional-index
#20
Xiao-Yi Zhou, Xi-Ming Xu, Jian-Ping Fan, Fei Wang, Sui-Yi Wu, Zi-Cheng Zhang, Yi-Lin Yang, Ming Li, Xian-Zhao Wei
BACKGROUND: No effective constructs were available in mainland China to assess the whole spine function. The SFI was developed to evaluate spinal function based on the concept of a single kinetic chain concept for whole spine. The SFI has been translated to Spanish and Turkish with accepted psychometric properties. It is imperative to introduce the SFI in mainland China and further to explore the measurement properties. METHODS: The English versions of the SFI was cross-culturally translated according to international guidelines...
October 18, 2017: Health and Quality of Life Outcomes
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