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https://www.readbyqxmd.com/read/28646695/pre-polarization-fields-for-earth-s-field-nmr-fast-discharge-for-use-with-short-t1-and-large-coils
#1
Mark S Conradi, Stephen A Altobelli, Nicholas J Sowko, Susan H Conradi, Eiichi Fukushima
The sensitivity of earth's field NMR is greatly increased by the use of a pre-polarizing field Bp. When used with short T1 samples, the field must be decreased rapidly to avoid loss of the pre-polarized magnetization by relaxation. Such a rapid decrease in the field requires rapid discharge (∼10ms) of a large stored magnetic field energy (∼700J). In addition, in order that the full pre-polarized magnetization be available for the subsequent pulse sequence, the field discharge should be adiabatic. This requirement is difficult to fulfill in cases where Bp is not everywhere parallel to the earth's field, such as with a large surface coil...
June 21, 2017: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/28646648/natural-history-of-a-viral-cohesive-end-site-cosn-of-the-%C3%AE-like-phages
#2
Nicole Vahanian, Choon Seok Oh, Jean Sippy, Michael Feiss
The base pairs of cosN, the site where the 12 base-long cohesive ends are generated in λ-like phages, show partial-two fold rotational symmetry. In a bioinformatic survey, we found that the cosN changes in 12 natural cosN variants are restricted to bp 6-to-12 of the cohesive end sequence. In contrast, bp 1-5 of the cohesive end sequence are strictly conserved (13/13), as are the two bp flanking the left nicking site (bp -2 and -1). The bp flanking the right nick site (bp 13 and 14) are conserved in 12 of 13 variants...
June 21, 2017: Virology
https://www.readbyqxmd.com/read/28646394/the-antihypertensive-efficacy-of-the-triple-fixed-combination-of-perindopril-indapamide-and-amlodipine-the-results-of-the-petra-study
#3
György Ábrahám, Csaba András Dézsi
INTRODUCTION: The etiology of essential hypertension is multifactorial. Therefore, treatment with combinations of antihypertensive agents acting on multiple targets is necessary for successful therapy in the majority of patients. According to the experience and clinical data accumulated so far, combination therapy with three agents from different pharmacological classes is required in approx. 30% of patients in order to achieve long-term blood pressure control. The primary objective of the PETRA study was to evaluate the efficacy of blood pressure (BP) control with once daily administration of the different dosage strengths of the once-daily, triple fixed combination of perindopril, indapamide, and amlodipine...
June 23, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28646230/il-1%C3%AE-increases-asporin-expression-via-the-nf-%C3%AE%C2%BAb-p65-pathway-in-nucleus-pulposus-cells-during-intervertebral-disc-degeneration
#4
Shengjie Wang, Chao Liu, Zhongyi Sun, Peng Yan, He Liang, Kai Huang, Changwei Li, Jiwei Tian
Disc degeneration (DD) is a multifaceted chronic process that alters the structure and function of intervertebral discs. The pathophysiology of degeneration is not completely understood, but the consensus is that changes in genes encoding extracellular matrix (ECM) proteins in the disc are the leading factors contributing to DD. Asporin is an ECM protein that has been shown to be increased in degenerated intervertebral discs, but little is known about how asporin is regulated during DD. In exploring the intricate mechanism, we confirmed that asporin was abundantly increased in patients' degenerated nucleus pulposus...
June 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28646164/regulation-of-drosophila-lifespan-by-bellwether-promoter-alleles
#5
Júlia Frankenberg Garcia, Mary Anna Carbone, Trudy F C Mackay, Robert R H Anholt
Longevity varies among individuals, but how natural genetic variation contributes to variation in lifespan is poorly understood. Drosophila melanogaster presents an advantageous model system to explore the genetic underpinnings of longevity, since its generation time is brief and both the genetic background and rearing environment can be precisely controlled. The bellwether (blw) gene encodes the α subunit of mitochondrial ATP synthase. Since metabolic rate may influence lifespan, we investigated whether alternative haplotypes in the blw promoter affect lifespan when expressed in a co-isogenic background...
June 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28646134/complete-mitochondrial-genome-of-clistocoeloma-sinensis-brachyura-grapsoidea-gene-rearrangements-and-higher-level-phylogeny-of-the-brachyura
#6
Zhao-Zhe Xin, Yu Liu, Dai-Zhen Zhang, Xin-Yue Chai, Zheng-Fei Wang, Hua-Bin Zhang, Chun-Lin Zhou, Bo-Ping Tang, Qiu-Ning Liu
Deciphering the animal mitochondrial genome (mitogenome) is very important to understand their molecular evolution and phylogenetic relationships. In this study, the complete mitogenome of Clistocoeloma sinensis was determined. The mitogenome of C. sinensis was 15,706 bp long, and its A+T content was 75.7%. The A+T skew of the mitogenome of C. sinensis was slightly negative (-0.020). All the transfer RNA genes had the typical cloverleaf structure, except for the trnS1 gene, which lacked a dihydroxyuridine arm...
June 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28645730/the-relation-of-digital-vascular-function-to-cardiovascular-risk-factors-in-african-americans-using-digital-tonometry-the-jackson-heart-study
#7
Eric E McClendon, Solomon K Musani, Tandaw E Samdarshi, Sushant Khaire, Donny Stokes, Naomi M Hamburg, Koby Sheffy, Gary F Mitchell, Herman R Taylor, Emelia J Benjamin, Ervin R Fox
Digital vascular tone and function, as measured by peripheral arterial tonometry (PAT), are associated with cardiovascular risk and events in non-Hispanic whites. There are limited data on relations between PAT and cardiovascular risk in African-Americans. PAT was performed on a subset of Jackson Heart Study participants using a fingertip tonometry device. Resting digital vascular tone was assessed as baseline pulse amplitude. Hyperemic vascular response to 5 minutes of ischemia was expressed as the PAT ratio (hyperemic/baseline amplitude ratio)...
June 2017: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/28645646/association-of-bullous-pemphigoid-with-malignancy-a-systematic-review-and-meta-analysis
#8
Lihi Atzmony, Ilit Mimouni, Ofer Reiter, Yael Anne Leshem, Omar Taha, Michael Gdalevich, Emmilia Hodak, Daniel Mimouni
BACKGROUND: Studies evaluating whether malignancy rate is increased in patients with bullous pemphigoid (BP) have reached conflicting results. OBJECTIVE: We sought to determine whether BP is associated with malignancy. METHOD: Medline, EMBASE, the Cochrane library, and reference lists of included studies were searched for comparative studies that evaluated the relationship between BP and malignancy. Data were analyzed on the basis of study design: cross-sectional, case control, and cohort...
June 20, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28645155/features-of-genomic-organization-in-a-nucleotide-resolution-molecular-model-of-the-escherichia-coli-chromosome
#9
William C Hacker, Shuxiang Li, Adrian H Elcock
We describe structural models of the Escherichia coli chromosome in which the positions of all 4.6 million nucleotides of each DNA strand are resolved. Models consistent with two basic chromosomal orientations, differing in their positioning of the origin of replication, have been constructed. In both types of model, the chromosome is partitioned into plectoneme-abundant and plectoneme-free regions, with plectoneme lengths and branching patterns matching experimental distributions, and with spatial distributions of highly-transcribed chromosomal regions matching recent experimental measurements of the distribution of RNA polymerases...
June 22, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28645074/relationship-between-inter-arm-blood-pressure-difference-and-severity-of-coronary-atherosclerosis
#10
Se-Jun Park, Jung-Woo Son, Sang-Min Park, Hyun-Hee Choi, Kyung-Soon Hong
BACKGROUND AND AIMS: A greater inter-arm blood pressure difference (IABPD) is associated with atherosclerosis, but its association with coronary artery disease is unknown. We investigated the relationship between IABPD and coronary atherosclerosis. METHODS: We retrospectively reviewed blood pressure (BP) data that was measured simultaneously in both arms of patients who underwent initial coronary angiography. Coronary atherosclerosis was assessed using the Gensini score, based on quantitative coronary angiography findings...
June 9, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28644975/a-neural-blood-pressure-marker-for-bioelectronic-medicines-for-treatment-of-hypertension
#11
Cristian Sevcencu, Thomas N Nielsen, Johannes J Struijk
A novel therapeutic approach for treating resistant hypertension could be the use of bioelectronic medicines to achieve blood pressure (BP) control in implanted patients by closed-loop stimulation of the left vagus nerve (LVN). However, such a technology would require an implantable BP marker, which is not available yet. As it is known that the LVN conducts afferent BP-related signals, this study aimed to investigate if such signals could be recorded with implantable means and used to derive BP markers. The present experiments were performed in anesthetized pigs subjected to a transient or stable BP increase induced by adrenaline administration...
June 17, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28644236/cyp1b1-cytopathy-uncommon-phenotype-of-a-homozygous-cyp1b1-deletion-as-internal-corneal-ulcer-of-von-hippel
#12
Valeria Oliva-Biénzobas, Alejandro Navas, Mirena C Astiazarán, Oscar Francisco Chacón-Camacho, Jose A Bermúdez-Magner, Mariana Takane, Enrique Graue-Hernández, Juan Carlos Zenteno
PURPOSE: To report a mutation of CYP1B1 in a newborn with a rare phenotype without the classic features of anterior segment dysgenesis or congenital glaucoma. METHODS: The newborn presented with diffuse corneal edema and bilaterally elevated intraocular pressure (IOP). Ophthalmological examination, ultrasound, and ultrasound biomicroscopy were performed; congenital infections were ruled out. Genetic analysis was performed. The patient underwent penetrating keratoplasty and goniotomy in a single surgical time...
June 21, 2017: Cornea
https://www.readbyqxmd.com/read/28643863/design-of-iron-ii-pthalocyanine-fepc-derived-oxygen-reduction-electrocatalysts-for-high-power-density-microbial-fuel-cells
#13
Carlo Santoro, Rohan Gokhale, Barbara Mecheri, Alessandra D'Epifanio, Silvia Licoccia, Alexey Serov, Kateryna Artyushkova, Plamen Atanassov
Iron(II) Phthalocyanine (FePc) deposited onto two different carbonaceous supports was synthesized by the non-conventional pyrolysis-free method, studied in the reaction of oxygen reduction (ORR) in neutral media, incorporated in an air-breathing cathode structure and tested in operating microbial fuel cell (MFC) configuration. Rotating ring disk electrode (RRDE) analysis revealed high performances of the Fe-based catalysts compared with activated carbon (AC). It was shown that Black Pearls supported FePc (Fe-BP(N)) exhibits the highest performance in term of more positive onset, positive shift of half-wave potential and higher limiting as well as highest power density in operating MFC (243±7 μWcm-2) that was 33% higher than Fe-CNT(N) (182±5 μWcm-2)...
June 23, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28643803/vhl-deficiency-augments-anthracycline-sensitivity-of-clear-cell-renal-cell-carcinomas-by-down-regulating-aldh2
#14
Yao-Hui Gao, Zhao-Xia Wu, Li-Qi Xie, Cai-Xia Li, Yu-Qin Mao, Yan-Tao Duan, Bing Han, San-Feng Han, Yun Yu, Hao-Jie Lu, Peng-Yuan Yang, Tian-Rui Xu, Jing-Lin Xia, Guo-Qiang Chen, Li-Shun Wang
The von Hippel-Lindau (VHL) is deficient in ∼70% of clear-cell renal cell carcinomas (ccRCC), which contributes to the carcinogenesis and drug resistance of ccRCC. Here we show that VHL-deficient ccRCC cells present enhanced cytotoxicity of anthracyclines in a hypoxia-inducible factor-independent manner. By subtractive proteomic analysis coupling with RNAi or overexpression verification, aldehyde dehydrogenase 2 (ALDH2) is found to be transcriptionally regulated by VHL and contributes to enhanced anthracyclines cytotoxicity in ccRCC cells...
June 15, 2017: Nature Communications
https://www.readbyqxmd.com/read/28643526/association-between-cotinine-verified-smoking-status-and-hypertension-in-167-868-korean-adults
#15
Byung Jin Kim, Ji Min Han, Jung Gyu Kang, Bum Soo Kim, Jin Ho Kang
PURPOSE: Previous studies showed inconsistent results concerning the relationship between chronic smoking and blood pressure. Most of the studies involved self-reported smoking status. This study was performed to evaluate the association of urinary cotinine or self-reported smoking status with hypertension and blood pressure in Korean adults. MATERIALS AND METHODS: Among individuals enrolled in the Kangbuk Samsung Health Study and Kangbuk Samsung Cohort Study, 167,868 participants (men, 55...
June 23, 2017: Blood Pressure
https://www.readbyqxmd.com/read/28642968/enhancing-the-enzymatic-saccharification-of-bamboo-shoot-shell-by-sequential-biological-pretreatment-with-galactomyces-sp-cczu11-1-and-deep-eutectic-solvent-extraction
#16
Yong Dai, Hai-Sheng Zhang, Bin Huan, Yucai He
In this study, sequential biological pretreatment (BP) with Galactomyces sp. CCZU11-1 at 30 °C for 3 days and deep eutectic solvent (DES) choline chloride: oxalic acid (ChCl:OA, 1 mol/2 mol) extraction at 120 °C for 1.5 h was used for pretreating BSS. It was found that combination pretreatment could effectively remove xylan and lignin for enhancing enzymatic saccharification. The reducing sugars and glucose from the hydrolysis of 100 g/L pretreated BSS with complexed cellulases of Galactomyces sp. CCZU11-1 were obtained in the yields of 81...
June 22, 2017: Bioprocess and Biosystems Engineering
https://www.readbyqxmd.com/read/28642856/longitudinal-change-in-trabecular-bone-score-during-and-after-treatment-of-osteoporosis-in-postmenopausal-korean-women
#17
Mi-Seon Shin, Eun-Hee Cho, Ha Young Kim
BACKGROUND: The aim of this study was to evaluate the longitudinal changes of trabecular bone score (TBS) during and after bisphosphonate (BP) treatment in postmenopausal Korean women with osteoporosis. METHODS: We analyzed 191 patients who took BP and underwent bone mineral density (BMD) test for the period from January 2010 to December 2015. The mean follow up period during treatment and after treatment was 22.8 months and 18 months, respectively. The TBS and BMD values were evaluated by the percent changes relative to the baseline...
May 2017: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/28642853/paget-s-disease-skeletal-manifestations-and-effect-of-bisphosphonates
#18
Ho Kang, Young-Chang Park, Kyu Hyun Yang
BACKGROUND: Paget's disease of bone leads to change in the shape and size of the bone and results in reduced bone strength, leading to the complications of deformity, arthritis, and fracture. Due to unknown reasons, Paget's disease is rare in Asian descendants. We report the cases of Paget's disease who visited our institute for 15 years and reviewed the literatures. METHODS: We retrospectively reviewed the medical records and radiograms of 8 patients (6 female and 2 male) who were diagnosed as Paget's disease of bone...
May 2017: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/28642846/decreased-fitness-and-virulence-in-st10-escherichia-coli-harboring-blandm-5-and-mcr-1-against-a-st4981-strain-with-blandm-5
#19
Yawei Zhang, Kang Liao, Hua Gao, Qi Wang, Xiaojuan Wang, Henan Li, Ruobing Wang, Hui Wang
Although coexistence of blaNDM-5 and mcr-1 in Escherichia coli has been reported, little is known about the fitness and virulence of such strains. Three carbapenem-resistant Escherichia coli (GZ1, GZ2, and GZ3) successively isolated from one patient in 2015 were investigated for microbiological fitness and virulence. GZ1 and GZ2 were also resistant to colistin. To verify the association between plasmids and fitness, growth kinetics of the transconjugants were performed. We also analyzed genomic sequences of GZ2 and GZ3 using PacBio sequencing...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28642777/transcriptome-analysis-of-genes-associated-with-the-artemisinin-biosynthesis-by-jasmonic-acid-treatment-under-the-light-in-artemisia-annua
#20
Xiaolong Hao, Yijun Zhong, Xueqing Fu, Zongyou Lv, Qian Shen, Tingxiang Yan, Pu Shi, Yanan Ma, Minghui Chen, Xueying Lv, Zhangkuanyu Wu, Jingya Zhao, Xiaofen Sun, Ling Li, Kexuan Tang
Artemisinin is a sesquiterpene lactone endoperoxide extracted from a traditional Chinese medicinal plant Artemisia annua. Artemisinin-based combination therapies (ACTs) are recommended as the best treatment of malaria by the World Health Organization (WHO). Both the phytohormone jasmonic acid (JA) and light promote artemisinin biosynthesis in A. annua. Interestingly, we found that the increase of artemisinin biosynthesis by JA was dependent on light. However, the relationship between the two signal pathways mediated by JA and light remains unclear...
2017: Frontiers in Plant Science
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