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https://www.readbyqxmd.com/read/28922303/perioperative-outcomes-complications-and-efficacy-of-robotic-assisted-prolapse-repair-a-single-institution-study-of-196-patients
#1
Priyanka Gupta, Michael Ehlert, Jamie Bartley, Jason Gilleran, Kim A Killinger, Judith A Boura, Pradeep Nagaraju, Melissa Fischer
Abdominal pelvic organ prolapse repair is efficacious for uterovaginal and apical prolapse. We describe the safety and efficacy of robotic prolapse repair in a large teaching institution. METHODS: Consecutive robotic-assisted prolapse repairs at a single institution between 2006 and 2014 were retrospectively reviewed for patient characteristics, operative information, and outcomes. RESULTS: A total of 196 women (mean age, 61 ± 9 years) underwent robotic prolapse repair (189 sacrocolpopexy, 6 sacrohysteropexy, 1 enterocele repair)...
September 15, 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/28906566/minimally-invasive-small-intestinal-exploration-and-targeted-abdominal-organ-biopsy-with-a-wound-retraction-device-in-42-cats-2005-2015
#2
Jessica Baron, Michelle Giuffrida, Philipp D Mayhew, Ameet Singh, J Brad Case, William T N Culp, David E Holt, Kelli N Mayhew, Jeffrey J Runge
OBJECTIVE: To describe the surgical technique and evaluate short-term outcome after minimally invasive small intestinal exploration and targeted organ biopsy with a wound retractor device (WRD) in cats. STUDY DESIGN: Multi-institutional retrospective study. ANIMALS: Forty-two cats. METHODS: A wound retractor was inserted into the abdomen on the ventral midline through a 2-4 cm incision at the level of the umbilicus. Short segments (6-10 cm long) of intestinal tract were sequentially exteriorized and explored through the WRD...
September 14, 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/28874629/the-effect-of-intraperitoneal-n-acetylcysteine-on-postoperative-adhesions-in-rat-models
#3
Gizem Inal Aslan, Ibrahim Otgun, Tugba Acer, Merih Tepeoglu, Akgun Hicsonmez
AIM: In this study, we researched the effect of local administration of N-acetylcysteine (NAC) on postoperative intraabdominal adhesion formation in the rat models. METHODS: 20 female Wistar Albino rats which were 5-7 months old are used for the study. The rats were divided into two equal groups. Group one was administered saline solution (n=10) while group two was administered NAC (n=10) after caecal abrasion. They were dissected on postoperative tenth day and were examined macroscopically and microscopically for the adhesion formation...
2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/28844951/cholangiocytes-in-the-pathogenesis-of-primary-sclerosing-cholangitis-and-development-of-cholangiocarcinoma
#4
REVIEW
Brian K Chung, Tom H Karlsen, Trine Folseraas
Primary sclerosing cholangitis (PSC) is an idiopathic cholangiopathy strongly associated with inflammatory bowel disease (IBD) and characterized by cholestasis, chronic immune infiltration and progressive fibrosis of the intrahepatic and extrahepatic bile ducts. PSC confers a high risk of cholangiocarcinoma (CCA) with PSC-CCA representing the leading cause of PSC-associated mortality. PSC-CCA is derived from cholangiocytes and associated progenitor cells - a heterogeneous group of dynamic epithelial cells lining the biliary tree that modulate the composition and volume of bile production by the liver...
August 24, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28828112/small-bowel-volvulus-around-caesarian-section-scar-adhesions
#5
Adam Wright, Suzanne Chong, Jonathon Willatt
Small bowel obstruction secondary to adhesions is a recognized complication of Caesarian section. However, obstruction due to small bowel volvulus caused by adhesions at the Caesarian-section scar has not been reported. We report such a case identified on computed tomography. We review the literature on small bowel volvulus in pregnant patients and discuss the computed tomography findings.
September 2017: Radiology case reports
https://www.readbyqxmd.com/read/28814833/markers-of-oxidative-nitrosative-stress-and-inflammation-in-lung-tissue-of-rats-exposed-to-different-intravenous-iron-compounds
#6
Jorge E Toblli, Gabriel Cao, Jorge F Giani, Fernando P Dominici, Margarita Angerosa
Iron deficiency anemia is a frequent complication in clinical conditions such as chronic kidney disease, chronic heart failure, inflammatory bowel disease, cancer, and excessive blood loss. Given the ability of iron to catalyze redox reactions, iron therapy can be associated with oxidative stress. The lung is uniquely susceptible to oxidative stress, and little is known about the effects of intravenous iron treatment in this organ. This study characterized changes in markers of oxidative/nitrosative stress and inflammation in the lung of non-iron deficient, non-anemic rats treated with five weekly doses (40 mg iron per kg body weight) of low molecular weight iron dextran (LMWID), iron sucrose (IS), ferric carboxymaltose (FCM), ferumoxytol (FMX), iron isomaltoside 1000 (IIM), or saline (control)...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28811708/involvement-of-crf2-signaling-in-enterocyte-differentiation
#7
Benjamin Ducarouge, Marjolaine Pelissier-Rota, Rebecca Powell, Alain Buisson, Bruno Bonaz, Muriel Jacquier-Sarlin
AIM: To determine the role of corticotropin releasing factor receptor (CRF2) in epithelial permeability and enterocyte cell differentiation. METHODS: For this purpose, we used rat Sprague Dawley and various colon carcinoma cell lines (SW620, HCT8R, HT-29 and Caco-2 cell lines). Expression of CRF2 protein was analyzed by fluorescent immunolabeling in normal rat colon and then by western blot in dissociated colonic epithelial cells and in the lysates of colon carcinoma cell lines or during the early differentiation of HT-29 cells (ten first days)...
July 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28804488/anti-adhesion-therapies-in-inflammatory-bowel-disease-molecular-and-clinical-aspects
#8
REVIEW
Sebastian Zundler, Emily Becker, Carl Weidinger, Britta Siegmund
The number of biologicals for the therapy of immunologically mediated diseases is constantly growing. In contrast to other agents that were previously introduced in rheumatologic or dermatologic diseases and only later adopted for the treatment of inflammatory bowel diseases (IBDs), the field of IBD was ground breaking for the concept of anti-adhesion blockade. Anti-adhesion antibodies selectively target integrins controlling cell homing to the intestine, which leads to reduction of inflammatory infiltration to the gut in chronic intestinal inflammation...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28800626/targeting-lysyl-oxidase-reduces-peritoneal-fibrosis
#9
Christopher R Harlow, Xuan Wu, Marielle van Deemter, Fiona Gardiner, Craig Poland, Rebecca Green, Sana Sarvi, Pamela Brown, Karl E Kadler, Yinhui Lu, J Ian Mason, Hilary O D Critchley, Stephen G Hillier
BACKGROUND: Abdominal surgery and disease cause persistent abdominal adhesions, pelvic pain, infertility and occasionally, bowel obstruction. Current treatments are ineffective and the aetiology is unclear, although excessive collagen deposition is a consistent feature. Lysyl oxidase (Lox) is a key enzyme required for crosslinking and deposition of insoluble collagen, so we investigated whether targeting Lox might be an approach to reduce abdominal adhesions. METHODS: Female C57Bl/6 mice were treated intraperitoneally with multiwalled carbon nanotubes (NT) to induce fibrosis, together with chemical (ß-aminoproprionitrile-BAPN) or miRNA Lox inhibitors, progesterone or dexamethasone...
2017: PloS One
https://www.readbyqxmd.com/read/28797335/who-should-manage-patients-with-adhesive-small-bowel-obstruction
#10
REVIEW
Christopher T Aquina, Fergal J Fleming
No abstract text is available yet for this article.
September 2017: Advances in Surgery
https://www.readbyqxmd.com/read/28795970/machine-learning-based-gene-prioritization-identifies-novel-candidate-risk-genes-for-inflammatory-bowel-disease
#11
Ofer Isakov, Iris Dotan, Shay Ben-Shachar
BACKGROUND: The inflammatory bowel diseases (IBDs) are chronic inflammatory disorders, associated with genetic, immunologic, and environmental factors. Although hundreds of genes are implicated in IBD etiology, it is likely that additional genes play a role in the disease process. We developed a machine learning-based gene prioritization method to identify novel IBD-risk genes. METHODS: Known IBD genes were collected from genome-wide association studies and annotated with expression and pathway information...
August 8, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28795875/animal-models-for-studying-epithelial-barriers-in-neonatal-necrotizing-enterocolitis-inflammatory-bowel-disease-and-colorectal-cancer
#12
Tiaosi Xing, Rolando Camacho Salazar, Yan-Hua Chen
The intestinal epithelial cells line the luminal surface of the entire gastrointestinal tract which is crucial for the absorption of nutrients and prevention of pathogens entering from the external environment. The epithelial barrier plays an important role in organ development, disease pathogenesis, and aging. The major component of an epithelial barrier is the single columnar epithelium and tight junctions. Tight junctions are located at the most apical region of the junctional complex and contain many integral membrane proteins, such as occludin, the claudin family, and junctional adhesion molecules (JAMs)...
July 20, 2017: Tissue Barriers
https://www.readbyqxmd.com/read/28794464/expression-changes-in-pelvic-organ-prolapse-a-systematic-review-and-in-silico-study
#13
Maryam B Khadzhieva, Dmitry S Kolobkov, Svetlana V Kamoeva, Lyubov E Salnikova
Pelvic organ prolapse (POP) is a highly disabling condition common for a vast number of women worldwide. To contribute to existing knowledge in POP pathogenesis, we performed a systematic review of expression studies on both specific gene and whole-genome/proteome levels and an in silico analysis of publicly available datasets related to POP development. The most extensively investigated genes in individual studies were related to extracellular matrix (ECM) organization. Three premenopausal and two postmenopausal sets from two Gene Expression Omnibus (GEO) studies (GSE53868 and GSE12852) were analyzed; Gene Ontology (GO) terms related to tissue repair (locomotion, biological adhesion, immune processes and other) were enriched in all five datasets...
August 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28770343/value-of-gastrografin-in-adhesive-small-bowel-obstruction
#14
Anna Weiss, Divya Sood, Scott E Greenway, Marco Tomassi
BACKGROUND: Small bowel obstruction (SBO) from adhesive disease presents great burden for the healthcare system. Some groups have reported water soluble contrast agents (WSCA) protocols, but published studies are underpowered. This study introduces a WSCA protocol to improve outcomes and streamline patient care. STUDY DESIGN: The study ran July 1, 2013-June 30, 2015, at Kaiser Permanente San Diego; protocol started July 1, 2014. Data was collected prospectively, on an intention to treat basis...
August 2, 2017: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/28764764/sclerosing-mesenteritis-in-a-5-year-old-chinese-boy-a-case-report
#15
Cui-Ping Liang, Min Yang, Pei-Yu Chen, Lan-Lan Geng, Ding-You Li, Si-Tang Gong
BACKGROUND: Sclerosing mesenteritis is a rare fibroinflammatory disorder of unknown etiology that primarily affects the mesentery of the small intestine during late adult life. Only about twenty pediatric cases have been reported to date, but none has been reported in Chinese children. CASE PRESENTATION: A 5-year-old Chinese male presented with a 4-week history of recurrent bloating, abdominal pain, anorexia and vomiting. On admission, physical examination showed a severely distended abdomen...
August 1, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28759326/assessment-of-strangulation-in-adhesive-small-bowel-obstruction-on-the-basis-of-combined-ct-findings-implications-for-clinical-care
#16
Ingrid Millet, Delphine Boutot, Claire Faget, Emmanuelle Pages-Bouic, Nicolas Molinari, Marc Zins, Patrice Taourel
Purpose To determine which computed tomography (CT) findings or combinations of findings can help to accurately identify strangulation in adhesive small bowel obstruction (SBO). Materials and Methods Contrast agent-enhanced CT findings in a cohort of 256 patients consecutively admitted for adhesive SBO, with a delay of less than 24 hours between CT and surgery for the operated patients, were reviewed independently by two radiologists, with consensus by a third, to assess CT findings commonly associated with strangulation...
July 31, 2017: Radiology
https://www.readbyqxmd.com/read/28743527/effectiveness-and-complications-of-augmentation-cystoplasty-with-or-without-non-refluxing-ureteral-reimplantation-in-adult-patients-with-long-standing-bladder-dysfunction-a-single-center-11-year-experience-in-173-cases
#17
Zhaoxia Wang, Limin Liao
PURPOSE: To review our experience for effectiveness and complications of augmentation cystoplasty (AC) with or without non-refluxing ureteral reimplantation in adult patients with long-standing bladder dysfunction MATERIAL AND METHODS: We retrospectively reviewed 173 patients who underwent AC with or without ureteral re-implantation (UR) at our center from July 2005 to July 2016. Clinical data, magnetic resonance urography (MRU), and video-urodynamics (VUD) parameters were collected. The upper urinary tract dilation (UUTD) and vesicoureteral reflux (VUR) grading systems were used to evaluate upper urinary tract function...
July 22, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28735976/predictive-value-of-procalcitonin-for-intestinal-ischemia-and-or-necrosis-in-pediatric-patients-with-adhesive-small-bowel-obstruction-asbo
#18
Eduardo Bracho-Blanchet, Alfredo Dominguez-Muñoz, Emilio Fernandez-Portilla, Cristian Zalles-Vidal, Roberto Davila-Perez
PURPOSE: Evaluate serum procalcitonin (PCT) level as a predictor of intestinal ischemia or necrosis (IN) in patients with postoperative adhesive small bowel obstruction (ASBO). METHODS: Prospective cohort of consecutive patients with ASBO. Patients previously treated with antibiotics or septic were excluded. PCT was measured at the diagnosis of ASBO and every 24 h afterwards. MAIN OUTCOME: intestinal ischemia or necrosis (IN). RESULTS: Fifty-nine patients were included, 12 of whom were excluded; 47 patients remained in the study; male-to-female ratio = 1...
July 13, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28735704/effect-of-remote-cesarean-delivery-on-complications-during-hysterectomy-a-cohort-study
#19
Susanne Hesselman, Ulf Högberg, Maria Jonsson
BACKGROUND: Cesarean delivery is performed frequently worldwide, and follow-up studies that report complications at subsequent surgery are warranted. OBJECTIVES: The aim of the study was to investigate the association between a previous abdominal delivery and complications during a subsequent hysterectomy and to estimate the fraction of complications that are driven by the presence of adhesions. STUDY DESIGN: This was a longitudinal population-based register study of 25354 women who underwent a benign hysterectomy at 46 hospital units in Sweden 2000-2014...
July 21, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28734829/feasibility-of-prophylactic-salpingectomy-during-vaginal%C3%A2-hysterectomy
#20
Danielle D Antosh, Rachel High, Heidi W Brown, Sallie S Oliphant, Husam Abed, Nisha Philip, Cara L Grimes
BACKGROUND: The American Congress of Obstetricians and Gynecologists recommends that "the surgeon and patient discuss the potential benefits of the removal of the fallopian tubes during a hysterectomy in women at population risk of ovarian cancer who are not having an oophorectomy," resulting in an increasing rate of salpingectomy at the time of hysterectomy. Rates of salpingectomy are highest for laparoscopic and lowest for vaginal hysterectomy. OBJECTIVE: The primary objective of this study was to determine the feasibility of bilateral salpingectomy at the time of vaginal hysterectomy...
July 20, 2017: American Journal of Obstetrics and Gynecology
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