Yihong Zhang, Wanling Liu, Gen Wei, Quanyi Liu, Guoqiang Shao, Xiang Gu, Xiaomiao Cui, Zijun Zhou, Yuting Wang, Sheng Zhao, Faheem Muhammad, Sirong Li, Tong Li, Yan Du, Hui Wei
Urinary tract infections (UTIs), common bacterial infections in communities and medical facilities, are mainly mediated by FimH. The glycan sites of the uromodulin protein play a crucial role in protecting against UTIs by interacting with FimH. A bioinspired approach using glycan-FimH interactions may effectively reduce bacteria through an antiadhesive mechanism, thereby curbing bacterial resistance. However, typical antiadhesive therapy alone fails to address the excessive reactive oxygen species and inflammatory response during UTIs...
March 14, 2024: ACS Nano